TDMS Study 96007-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) DATE: 09/29/03
EXPERIMENT: 96007 TEST: 04 TIME: 12:11:17
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: 96007B
PATHOLOGIST: SELLS, DONALD CAS: TEFDIOXINMIX
------------------------------------------------------------------------------------------------------------------------------------
FINAL#4/RATS
REASONS FOR REMOVAL: 25018 Dosing Accident
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) DATE: 09/29/03
EXPERIMENT: 96007 TEST: 04 TIME: 12:11:17
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: 96007B
PATHOLOGIST: SELLS, DONALD CAS: TEFDIOXINMIX
TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = TERT.MIXCONTROL |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 176 218 276 387 416 435 444 454 456 484 |
| 500 508 526 540 568 575 587 625 625 626 |
| 627 631 645 655 658 666 668 668 669 682 |
| 682 693 702 715 721 723 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = TERT.MIXTEQ=10 |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 227 350 362 416 455 456 498 540 546 548 |
| 562 563 563 626 627 627 627 631 652 659 |
| 668 668 669 669 683 689 702 702 718 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = TERT.MIXTEQ=22 |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 28 CENSORED DEATHS 1 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 203 263 322 456 526 529 540 548 592 609 |
| 616 617 621 639 652 659 659 666 669 669 |
| 683 699 702 702 702 703 709 723 |
| CENSORED DEATHS |
| 46 |
| |
==================================================================================
TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = TERT.MIXTEQ=46 |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 29 CENSORED DEATHS 1 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 276 315 322 333 469 490 505 521 521 542 |
| 548 585 616 619 626 626 668 668 668 669 |
| 669 669 669 669 682 682 682 697 702 |
| CENSORED DEATHS |
| 465 |
| |
|--------------------------------------------------------------------------------|
| DOSE = TERT.MIXTEQ=100 |
| ---------------------------- |
| |
| TOTAL 53 UNCENSORED DEATHS 43 CENSORED DEATHS 2 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 2 287 312 339 387 409 434 434 497 498 |
| 526 542 546 548 548 562 563 575 589 592 |
| 598 598 617 623 631 633 634 639 658 666 |
| 674 674 674 682 682 688 689 689 715 718 |
| 721 728 728 |
| CENSORED DEATHS |
| 392 399 |
| |
==================================================================================
TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|TERT.MIXCON|ROL100.0 98.1 96.2 94.3 90.6 81.1 73.6 67.9 52.8 30.2 |
|T | |
| | |
|TERT.MIXTEQ|10 100.0 100.0 98.1 94.3 92.5 88.7 84.9 75.5 62.3 43.4 |
| | |
| | |
|TERT.MIXTEQ|22 100.0 100.0 96.2 94.2 94.2 92.3 86.5 82.7 67.3 46.2 |
| | |
| | |
|TERT.MIXTEQ|46 100.0 100.0 100.0 92.5 92.5 90.5 80.9 77.0 69.3 44.3 |
| | |
| | |
|TERT.MIXTEQ|100 98.1 98.1 98.1 92.5 88.6 84.7 76.8 57.1 43.3 15.8 |
|T | |
| | |
==================================================================================
TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| TERT.MIXCONTROL TERT.MIXTEQ=10 TERT.MIXTEQ=22 TERT.MIXTEQ=46 TERT.MIXTEQ=100 |
| T T |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 30.2% 43.4% 46.2% 44.3% 15.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.012 P=0.195N P=0.080N P=0.160N P=0.165 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 566.4 580.8 595.6 576.1 570.9 |
|NATURAL DEATHS (C) | (23.4) (22.5) (25.6) (23.7) (22.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 615.5 645.1 645.7 640.4 588.2 |
|(STANDARD ERROR) | (19.3) (16.2) (19.9) (16.9) (20.3) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE)
KAPLAN-MEIER SURVIVAL CURVES
TERT.MIXCONTROL = 1
TERT.MIXTEQ=10 = 2
TERT.MIXTEQ=22 = 3
TERT.MIXTEQ=46 = 4
TERT.MIXTEQ=100 = 5
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 15 1 3 2 4
| 5 1 3 12 3 45 4 2
| 1 3 15 43 452 2 1 2 3
| 45 1 1 234 3
90 + 5 51 1 224 4
| 5 511 12 4 24 43 23
| 5 11 5 3 3
| 1 155 4 22 3 3
80 + 1 11 5 42 2 4 333
| 1 1 4 4
P | 1 15 2 432 3
E | 1 11 44 3 3
R 70 + 5 5 11 4 3 34
C | 5 51 12 33
E | 5 5 2 2 2
N | 22 3
T 60 + 55 11 3 3
| 5 5 1 11 33
S | 2 2
U | 5 5 1 1 22
R 50 + 2 23
V | 55 4 42323
I | 5 5 1 1 44 3 3
V | 5 5511 2 2
A 40 + 1 1
L | 1 1
| 55 11
| 55
30 + 1 1
|
| 5 5
|
20 + 55
|
| 5 5
|
10 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 39 obs hidden.