TDMS Study 96007-05 Pathology Tables
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/14/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Time: 14:41:20
14 WEEK SSAC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57117-31-4
Lock Date: 07/25/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 07/08/99 - 07/09/99
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/14/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Time: 14:41:20
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SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98 98
Scheduled Sacrifice 16 16 16 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Fatty Change, Diffuse 2 [1.0]
Inflammation 9 [1.0] 10 [1.0] 10 [1.0] 10 [1.1] 10 [1.1] 10 [1.0]
Pigmentation 2 [1.0]
Hepatocyte, Hypertrophy 1 [1.0] 3 [1.0] 3 [1.0] 4 [1.0] 7 [1.0]
Pancreas (10) (10)
Acinus, Atrophy 1 [2.0]
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Thyroid Gland (10) (10) (10) (10) (9) (10)
Follicular Cell, Hypertrophy 3 [1.0] 3 [1.3] 4 [1.0] 7 [1.4] 7 [2.0]
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (10) (10) (10) (10) (10)
Atrophy 1 [3.0] 1 [3.0] 1 [4.0] 1 [3.0] 3 [3.0]
Uterus (10) (10)
Metaplasia, Squamous 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/14/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Time: 14:41:20
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
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GENITAL SYSTEM - CONT
Endometrium, Hyperplasia, Cystic 4 [3.3] 3 [3.7]
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HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Pigmentation 10 [1.0] 10 [1.0]
Thymus (10) (9) (8) (9) (10) (10)
Atrophy 3 [1.0] 2 [1.0]
Necrosis 1 [1.0]
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (10)
Inflammation 1 [1.0]
Inflammation, Chronic Active 2 [2.0] 4 [1.8]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/14/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Time: 14:41:20
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 200 NG/
KG STOP
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DISPOSITION SUMMARY
Animals Initially In Study 50
Early Deaths
Survivors
Animals Examined Microscopically
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ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/14/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Time: 14:41:20
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 200 NG/
KG STOP
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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