TDMS Study 96007-05 Pathology Tables
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:42:22
31 WEEK SSAC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57117-31-4
Lock Date: 07/25/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 11/03/99 - 11/04/99
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:42:22
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SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98 98
Scheduled Sacrifice 16 16 16 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Basophilic Focus 2 (20%) 1 (10%)
Cholangiofibrosis 1 (10%)
Eosinophilic Focus 1 (10%)
Fatty Change, Diffuse 1 (10%)
Inflammation 9 (90%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Mixed Cell Focus 1 (10%) 3 (30%) 2 (20%) 1 (10%) 2 (20%) 1 (10%)
Mixed Cell Focus, Multiple 4 (40%) 1 (10%) 3 (30%) 2 (20%) 4 (40%)
Pigmentation 1 (10%) 3 (30%) 4 (40%) 7 (70%) 8 (80%)
Bile Duct, Fibrosis 1 (10%)
Bile Duct, Hyperplasia 1 (10%)
Hepatocyte, Hypertrophy 1 (10%) 3 (30%) 6 (60%) 8 (80%) 8 (80%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Hypertrophy 1 (10%) 2 (20%)
Pituitary Gland (10) (10)
Hyperplasia 1 (10%)
Thyroid Gland (10) (10) (10) (10) (10) (10)
Follicular Cell, Hypertrophy 2 (20%) 1 (10%) 5 (50%) 3 (30%) 2 (20%) 3 (30%)
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GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:42:22
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10) (10) (10)
Atrophy 5 (50%) 7 (70%) 7 (70%) 6 (60%) 8 (80%) 9 (90%)
Cyst 1 (10%) 1 (10%) 2 (20%)
Uterus (10) (10) (10) (10) (10) (10)
Inflammation, Suppurative 1 (10%) 1 (10%) 1 (10%)
Metaplasia, Squamous 5 (50%) 6 (60%) 3 (30%) 5 (50%) 6 (60%) 3 (30%)
Endometrium, Hyperplasia, Cystic 4 (40%) 2 (20%) 4 (40%) 6 (60%) 7 (70%) 8 (80%)
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HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Pigmentation 10 (100%) 10 (100%)
Thymus (10) (10) (10) (10) (10) (10)
Atrophy 1 (10%) 2 (20%) 5 (50%)
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INTEGUMENTARY SYSTEM
Mammary Gland (10) (2) (1) (1) (10)
Cyst 1 (10%) 1 (100%)
Hyperplasia 1 (10%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:42:22
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:42:22
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 200 NG/
KG STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50
Early Deaths
Survivors
Animals Examined Microscopically
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:42:22
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 200 NG/
KG STOP
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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