TDMS Study 96007-05 Pathology Tables
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:54:42
53 WEEK SSAC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57117-31-4
Lock Date: 07/25/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 04/06/00 - 04/07/00
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:54:42
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98 98
Scheduled Sacrifice 13 13 13 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8 8
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ALIMENTARY SYSTEM
Liver (8) (8) (8) (8) (8) (8)
Angiectasis 1 (13%)
Basophilic Focus 1 (13%) 1 (13%) 3 (38%) 1 (13%)
Clear Cell Focus, Multiple 1 (13%)
Eosinophilic Focus 1 (13%)
Fatty Change, Diffuse 3 (38%)
Hepatodiaphragmatic Nodule 1 (13%)
Inflammation 8 (100%) 8 (100%) 8 (100%) 7 (88%) 8 (100%) 8 (100%)
Mixed Cell Focus 2 (25%) 1 (13%) 3 (38%) 1 (13%) 3 (38%)
Mixed Cell Focus, Multiple 5 (63%) 5 (63%) 3 (38%) 7 (88%) 3 (38%) 6 (75%)
Necrosis 1 (13%) 1 (13%) 2 (25%)
Pigmentation 1 (13%) 1 (13%) 6 (75%) 7 (88%) 8 (100%)
Toxic Hepatopathy 1 (13%)
Bile Duct, Cyst 2 (25%)
Bile Duct, Fibrosis 1 (13%) 1 (13%) 1 (13%)
Bile Duct, Hyperplasia 1 (13%) 1 (13%)
Hepatocyte, Hypertrophy 1 (13%) 3 (38%) 3 (38%) 3 (38%) 5 (63%) 7 (88%)
Hepatocyte, Multinucleated 1 (13%) 2 (25%)
Pancreas (8) (8)
Hyperplasia 1 (13%)
Inflammation, Chronic Active 1 (13%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (8) (8)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:54:42
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Degeneration, Cystic 1 (13%)
Hyperplasia 1 (13%) 2 (25%)
Hypertrophy 4 (50%) 6 (75%)
Vacuolization Cytoplasmic 2 (25%)
Pituitary Gland (8) (8)
Hyperplasia 2 (25%)
Pars Distalis, Hyperplasia 1 (13%)
Thyroid Gland (8) (8) (7) (8) (8) (8)
C-Cell, Hyperplasia 2 (25%)
Follicular Cell, Hypertrophy 2 (25%) 3 (38%) 1 (14%) 3 (38%) 4 (50%) 5 (63%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (1) (2) (1) (8)
Atrophy 8 (100%) 7 (88%)
Cyst 1 (13%) 2 (100%)
Oviduct (1)
Cyst 1 (100%)
Uterus (8) (1) (2) (1) (1) (8)
Inflammation, Chronic Active 2 (100%) 1 (100%)
Inflammation, Suppurative 2 (25%) 1 (13%)
Metaplasia, Squamous 8 (100%) 1 (100%) 1 (50%) 7 (88%)
Endometrium, Hyperplasia, Cystic 6 (75%) 1 (100%) 1 (100%) 8 (100%)
Epithelium, Hyperplasia 2 (100%)
Vagina (8) (8)
Vacuolization Cytoplasmic 1 (13%)
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HEMATOPOIETIC SYSTEM
Spleen (8) (8)
Pigmentation 8 (100%) 8 (100%)
Thymus (8) (8) (8) (8) (8) (8)
Atrophy 5 (63%) 4 (50%) 6 (75%) 6 (75%) 5 (63%) 7 (88%)
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a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:54:42
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (8) (1) (1) (2) (8)
Cyst 1 (100%) 1 (50%) 1 (13%)
Hyperplasia 3 (38%)
Inflammation, Chronic 1 (100%) 1 (50%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (1) (8)
Infiltration Cellular, Histiocyte 4 (50%) 1 (100%) 2 (25%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (1)
Inflammation, Chronic 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:54:42
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 200 NG/
KG STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50
Early Deaths
Survivors
Animals Examined Microscopically
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:54:42
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 200 NG/
KG STOP
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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