TDMS Study 96007-05 Pathology Tables
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
53 WEEK SSAC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57117-31-4
Lock Date: 07/25/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 04/06/00 - 04/07/00
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 7| 6| 6| 6| 6| 7| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG/KG | 1| 1| 2| 3| 3| 3| 3| 4| 7| 7| 7| 8| 9| | L |
| 6| 7| 2| 6| 7| 8| 9| 5| 6| 7| 8| 0| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X | 1 |
Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0|
Mixed Cell Focus | X X | 2 |
Mixed Cell Focus, Multiple | X X X X X | 5 |
Necrosis | 1 | 1 1.0|
Bile Duct, Fibrosis | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
Hyperplasia | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 1 1 2 1 | 4 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 7| 6| 6| 6| 6| 7| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG/KG | 1| 1| 2| 3| 3| 3| 3| 4| 7| 7| 7| 8| 9| | L |
| 6| 7| 2| 6| 7| 8| 9| 5| 6| 7| 8| 0| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
Follicular Cell, Hypertrophy | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 4 | 8 4.0|
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Inflammation, Suppurative | 2 1 | 2 1.5|
Metaplasia, Squamous | 2 2 2 3 2 2 2 2 | 8 2.1|
Endometrium, Hyperplasia, Cystic | 2 2 2 1 1 2 | 6 1.7|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
Pigmentation | 1 2 1 2 2 2 2 2 | 8 1.8|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 2 1 2 2 2 | 5 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 7| 6| 6| 6| 6| 7| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG/KG | 1| 1| 2| 3| 3| 3| 3| 4| 7| 7| 7| 8| 9| | L |
| 6| 7| 2| 6| 7| 8| 9| 5| 6| 7| 8| 0| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
6 NG/KG | 3| 3| 3| 4| 6| 6| 7| 7| 8| 8| 8| 8| 8| | L |
| 6| 8| 9| 0| 0| 6| 1| 4| 1| 2| 3| 4| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X | 1 |
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0|
Mixed Cell Focus | X | 1 |
Mixed Cell Focus, Multiple | X X X X X | 5 |
Necrosis | 1 | 1 1.0|
Pigmentation | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
Follicular Cell, Hypertrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + | 1 |
|__________________________________________________________________________|____________|
Oviduct | + | 1 |
Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + | 1 |
Metaplasia, Squamous | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
6 NG/KG | 3| 3| 3| 4| 6| 6| 7| 7| 8| 8| 8| 8| 8| | L |
| 6| 8| 9| 0| 0| 6| 1| 4| 1| 2| 3| 4| 6| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | + + + + + + + + | 8 |
Atrophy | 2 2 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + | 1 |
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
20 NG/KG | 0| 1| 4| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 2| 4| 9| 0| 2| 6| 8| 9| 0| 1| 2| 3| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Inflammation | 1 1 1 1 1 1 1 1 | 8 1.0|
Mixed Cell Focus | X X X | 3 |
Mixed Cell Focus, Multiple | X X X | 3 |
Necrosis | 1 1 | 2 1.0|
Pigmentation | 1 | 1 1.0|
Bile Duct, Fibrosis | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 7 |
Follicular Cell, Hypertrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + | 2 |
Cyst | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Uterus | + + | 2 |
Inflammation, Chronic Active | 2 2 | 2 2.0|
Metaplasia, Squamous | 4 | 1 4.0|
Epithelium, Hyperplasia | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
20 NG/KG | 0| 1| 4| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 2| 4| 9| 0| 2| 6| 8| 9| 0| 1| 2| 3| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Atrophy | 2 2 1 2 1 2 | 6 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
Cyst | 3 | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
44 NG/KG | 6| 7| 7| 7| 7| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 9| 5| 7| 8| 9| 0| 9| 0| 1| 3| 4| 5| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X X X | 3 |
Inflammation | 1 1 1 2 1 1 1 | 7 1.1|
Mixed Cell Focus | X | 1 |
Mixed Cell Focus, Multiple | X X X X X X X | 7 |
Pigmentation | 1 1 1 1 1 1 | 6 1.0|
Bile Duct, Fibrosis | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
Follicular Cell, Hypertrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + | 1 |
|__________________________________________________________________________|____________|
Uterus | + | 1 |
Endometrium, Hyperplasia, Cystic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 2 2 2 2 2 2 | 6 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 7| 6| 6| 6| 6| 7| 7| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
44 NG/KG | 6| 7| 7| 7| 7| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 9| 5| 7| 8| 9| 0| 9| 0| 1| 3| 4| 5| 7| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 6| 6| 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
92 NG/KG | 1| 1| 1| 1| 2| 2| 2| 6| 7| 7| 7| 7| 8| | L |
| 5| 6| 7| 9| 0| 1| 2| 2| 2| 3| 4| 5| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Inflammation | 2 1 1 1 1 1 1 1 | 8 1.1|
Mixed Cell Focus | X X X | 3 |
Mixed Cell Focus, Multiple | X X X | 3 |
Pigmentation | 1 1 1 1 1 1 1 | 7 1.0|
Bile Duct, Hyperplasia | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 1 1 1 1 1 | 5 1.0|
Hepatocyte, Multinucleated | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
Follicular Cell, Hypertrophy | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Uterus | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 2 3 2 1 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 7| 6| 6| 6| 6| 7| 7| 7| 6| 6| 6| 6| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
92 NG/KG | 1| 1| 1| 1| 2| 2| 2| 6| 7| 7| 7| 7| 8| | L |
| 5| 6| 7| 9| 0| 1| 2| 2| 2| 3| 4| 5| 2| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Mammary Gland | + + | 2 |
Cyst | 3 | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
200 | 0| 0| 0| 0| 0| 2| 2| 2| 3| 4| 7| 8| 9| | L |
NG/KG | 1| 2| 4| 5| 9| 6| 7| 9| 0| 0| 5| 5| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + | 8 |
Basophilic Focus | X | 1 |
Clear Cell Focus, Multiple | X | 1 |
Eosinophilic Focus | X | 1 |
Fatty Change, Diffuse | 1 1 1 | 3 1.0|
Inflammation | 2 1 1 1 1 1 1 2 | 8 1.3|
Mixed Cell Focus, Multiple | X X X X X X | 6 |
Pigmentation | 1 2 1 1 1 2 1 2 | 8 1.4|
Toxic Hepatopathy | 1 | 1 1.0|
Bile Duct, Cyst | 1 1 | 2 1.0|
Bile Duct, Hyperplasia | 1 | 1 1.0|
Hepatocyte, Hypertrophy | 1 1 1 1 2 3 1 | 7 1.4|
Hepatocyte, Multinucleated | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 8 |
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia | 3 2 | 2 2.5|
Hypertrophy | 1 1 1 1 2 1 | 6 1.2|
Vacuolization Cytoplasmic | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
200 | 0| 0| 0| 0| 0| 2| 2| 2| 3| 4| 7| 8| 9| | L |
NG/KG | 1| 2| 4| 5| 9| 6| 7| 9| 0| 0| 5| 5| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Islets, Pancreatic | + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 8 |
Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 8 |
C-Cell, Hyperplasia | 2 1 | 2 1.5|
Follicular Cell, Hypertrophy | 1 1 1 1 3 | 5 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 8 |
Atrophy | 4 4 4 4 4 4 4 | 7 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Inflammation, Suppurative | 1 | 1 1.0|
Metaplasia, Squamous | 2 2 2 2 2 2 2 | 7 2.0|
Endometrium, Hyperplasia, Cystic | 1 4 1 1 1 2 1 2 | 8 1.6|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + | 8 |
Vacuolization Cytoplasmic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 8 |
Pigmentation | 3 2 2 2 1 2 2 2 | 8 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 8 |
Atrophy | 3 3 3 2 2 2 3 | 7 2.6|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 96007-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 15:05:00
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | |
| 6| 6| 6| 6| 7| 6| 6| 6| 6| 7| 7| 7| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
200 | 0| 0| 0| 0| 0| 2| 2| 2| 3| 4| 7| 8| 9| | L |
NG/KG | 1| 2| 4| 5| 9| 6| 7| 9| 0| 0| 5| 5| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 8 |
Cyst | 3 | 1 3.0|
Hyperplasia | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Infiltration Cellular, Histiocyte | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
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