TDMS Study 96007-05 Pathology Tables
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/14/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Time: 15:05:14
53 WEEK SSAC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57117-31-4
Lock Date: 07/25/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 04/06/00 - 04/07/00
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/14/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Time: 15:05:14
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98 98
Scheduled Sacrifice 13 13 13 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8 8
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ALIMENTARY SYSTEM
Liver (8) (8) (8) (8) (8) (8)
Angiectasis 1 [1.0]
Basophilic Focus 1 1 3 1
Clear Cell Focus, Multiple 1
Eosinophilic Focus 1
Fatty Change, Diffuse 3 [1.0]
Hepatodiaphragmatic Nodule 1
Inflammation 8 [1.0] 8 [1.0] 8 [1.0] 7 [1.1] 8 [1.1] 8 [1.3]
Mixed Cell Focus 2 1 3 1 3
Mixed Cell Focus, Multiple 5 5 3 7 3 6
Necrosis 1 [1.0] 1 [1.0] 2 [1.0]
Pigmentation 1 [1.0] 1 [1.0] 6 [1.0] 7 [1.0] 8 [1.4]
Toxic Hepatopathy 1 [1.0]
Bile Duct, Cyst 2 [1.0]
Bile Duct, Fibrosis 1 [1.0] 1 [1.0] 1 [1.0]
Bile Duct, Hyperplasia 1 [1.0] 1 [1.0]
Hepatocyte, Hypertrophy 1 [1.0] 3 [1.0] 3 [1.0] 3 [1.0] 5 [1.0] 7 [1.4]
Hepatocyte, Multinucleated 1 [1.0] 2 [1.0]
Pancreas (8) (8)
Hyperplasia 1 [1.0]
Inflammation, Chronic Active 1 [2.0]
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (8) (8)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/14/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Time: 15:05:14
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
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ENDOCRINE SYSTEM - CONT
Degeneration, Cystic 1 [2.0]
Hyperplasia 1 [1.0] 2 [2.5]
Hypertrophy 4 [1.3] 6 [1.2]
Vacuolization Cytoplasmic 2 [1.5]
Pituitary Gland (8) (8)
Hyperplasia 2 [2.0]
Pars Distalis, Hyperplasia 1 [2.0]
Thyroid Gland (8) (8) (7) (8) (8) (8)
C-Cell, Hyperplasia 2 [1.5]
Follicular Cell, Hypertrophy 2 [1.0] 3 [1.0] 1 [1.0] 3 [1.0] 4 [1.0] 5 [1.4]
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (1) (2) (1) (8)
Atrophy 8 [4.0] 7 [4.0]
Cyst 1 [2.0] 2 [2.0]
Oviduct (1)
Cyst 1 [3.0]
Uterus (8) (1) (2) (1) (1) (8)
Inflammation, Chronic Active 2 [2.0] 1 [2.0]
Inflammation, Suppurative 2 [1.5] 1 [1.0]
Metaplasia, Squamous 8 [2.1] 1 [4.0] 1 [4.0] 7 [2.0]
Endometrium, Hyperplasia, Cystic 6 [1.7] 1 [4.0] 1 [4.0] 8 [1.6]
Epithelium, Hyperplasia 2 [2.5]
Vagina (8) (8)
Vacuolization Cytoplasmic 1 [3.0]
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HEMATOPOIETIC SYSTEM
Spleen (8) (8)
Pigmentation 8 [1.8] 8 [2.0]
Thymus (8) (8) (8) (8) (8) (8)
Atrophy 5 [1.8] 4 [2.0] 6 [1.7] 6 [2.0] 5 [2.0] 7 [2.6]
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a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/14/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Time: 15:05:14
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (8) (1) (1) (2) (8)
Cyst 1 [3.0] 1 [3.0] 1 [3.0]
Hyperplasia 3 [1.0]
Inflammation, Chronic 1 [2.0] 1 [2.0]
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (1) (8)
Infiltration Cellular, Histiocyte 4 [1.0] 1 [1.0] 2 [1.0]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (1)
Inflammation, Chronic 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/14/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Time: 15:05:14
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 200 NG/
KG STOP
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DISPOSITION SUMMARY
Animals Initially In Study 50
Early Deaths
Survivors
Animals Examined Microscopically
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ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 07/14/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Time: 15:05:14
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 200 NG/
KG STOP
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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