TDMS Study 96010-03 Pathology Tables
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
FINAL#1/RATS
Facility: Southern Research Institute
Chemical CAS #: 7775-09-9
Lock Date: 10/16/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 3 3 6 5
Moribund Sacrifice 10 11 11 4
Survivors
Terminal Sacrifice 37 34 32 40
Natural Death 1 1
Moribund Sacrifice 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (50) (49) (45) (49)
Amyloid Deposition 1 (2%)
Epithelium, Cyst 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis, Focal 2 (4%)
Basophilic Focus 42 (84%) 44 (88%) 41 (82%) 42 (84%)
Cholangiofibrosis 1 (2%) 1 (2%) 3 (6%)
Clear Cell Focus 6 (12%) 16 (32%) 18 (36%) 10 (20%)
Congestion 6 (12%) 2 (4%) 2 (4%) 1 (2%)
Degeneration, Cystic, Focal 1 (2%) 1 (2%) 3 (6%)
Eosinophilic Focus 1 (2%) 1 (2%) 2 (4%)
Fibrosis, Focal 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 7 (14%) 4 (8%) 8 (16%) 3 (6%)
Hyperplasia, Focal, Histiocytic 20 (40%) 19 (38%) 16 (32%) 23 (46%)
Hyperplasia, Focal, Regenerative 1 (2%) 1 (2%)
Hyperplasia, Regenerative 2 (4%)
Infarct, Multiple 1 (2%)
Infiltration Cellular, Focal,
Polymorphonuclear 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Infiltration Cellular, Mixed Cell 39 (78%) 38 (76%) 35 (70%) 41 (82%)
Mixed Cell Focus 12 (24%) 6 (12%) 7 (14%) 8 (16%)
Thrombosis 1 (2%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 29 (58%) 24 (48%) 34 (68%) 26 (52%)
Capsule, Cyst 1 (2%)
Hepatocyte, Karyomegaly 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Necrosis, Focal 2 (4%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 2 (4%)
Hepatocyte, Vacuolization Cytoplasmic,
Diffuse 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 17 (34%) 10 (20%) 10 (20%) 10 (20%)
Hepatocyte, Periportal, Vacuolization
Cytoplasmic 2 (4%)
Hepatocyte, Periportal, Centrilobular,
Vacuolization Cytoplasmic 1 (2%)
Hepatocyte, Centrilobular, Necrosis 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 5 (10%) 3 (6%) 8 (16%) 3 (6%)
Hepatocyte, Midzonal, Vacuolization
Cytoplasmic 2 (4%)
Mesentery (18) (10) (13) (16)
Inflammation, Chronic, Focal 1 (10%)
Fat, Necrosis 4 (22%) 2 (20%) 1 (8%)
Fat, Necrosis, Focal 12 (67%) 5 (50%) 9 (69%) 13 (81%)
Pancreas (50) (49) (49) (49)
Lipomatosis 1 (2%)
Acinus, Atrophy, Diffuse 1 (2%)
Acinus, Atrophy, Focal 15 (30%) 8 (16%) 9 (18%) 16 (33%)
Duct, Cyst, Focal 1 (2%) 2 (4%) 4 (8%) 1 (2%)
Duct, Cyst, Focal, Multiple 10 (20%) 14 (29%) 11 (22%) 18 (37%)
Duct, Hyperplasia, Focal 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy, Focal 2 (4%)
Stomach, Forestomach (50) (50) (50) (50)
Edema 1 (2%) 1 (2%) 1 (2%)
Erosion 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Perforation 1 (2%)
Ulcer 2 (4%) 7 (14%) 1 (2%)
Epithelium, Hyperplasia 2 (4%) 4 (8%) 6 (12%) 1 (2%)
Stomach, Glandular (50) (49) (49) (50)
Erosion 2 (4%) 2 (4%) 2 (4%)
Erosion, Focal 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis, Focal 1 (2%)
Pigmentation, Focal 1 (2%)
Ulcer 1 (2%)
Tooth (2) (2) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Malformation 1 (50%)
Dentine, Malformation 1 (50%)
Peridontal Tissue, Inflammation, Chronic 1 (50%) 2 (100%)
Peridontal Tissue, Inflammation, Chronic,
Focal 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Thrombosis 1 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 4 (8%) 2 (4%) 2 (4%)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%) 4 (8%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 2 (4%) 3 (6%) 5 (10%) 2 (4%)
Angiectasis 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Cytoplasmic Alteration, Focal 1 (2%) 2 (4%) 3 (6%) 2 (4%)
Degeneration, Cystic, Focal 1 (2%) 1 (2%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 2 (4%)
Infiltration Cellular, Mixed Cell 1 (2%)
Necrosis, Focal 1 (2%)
Vacuolization Cytoplasmic, Focal 7 (14%) 13 (26%) 7 (14%) 8 (16%)
Adrenal Medulla (50) (50) (50) (50)
Angiectasis 1 (2%)
Hyperplasia, Focal 3 (6%) 4 (8%) 1 (2%) 1 (2%)
Infiltration Cellular, Focal, Lymphoid 1 (2%)
Islets, Pancreatic (50) (49) (49) (50)
Hyperplasia, Focal 1 (2%)
Parathyroid Gland (47) (47) (48) (47)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (49) (49) (50) (50)
Angiectasis 10 (20%) 6 (12%) 2 (4%) 13 (26%)
Pigmentation, Focal 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 2 (4%) 2 (4%)
Pars Distalis, Cyst 2 (4%) 2 (4%) 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cytoplasmic Alteration, Focal 3 (6%) 1 (2%) 2 (4%) 3 (6%)
Pars Distalis, Degeneration, Cystic, Focal 11 (22%) 14 (29%) 11 (22%) 3 (6%)
Pars Distalis, Hemorrhage, Focal 9 (18%) 6 (12%) 10 (20%) 2 (4%)
Pars Distalis, Hyperplasia, Focal 7 (14%) 5 (10%) 10 (20%) 4 (8%)
Pars Distalis, Infiltration Cellular, Focal 1 (2%)
Pars Nervosa, Hyperplasia, Atypical, Focal 1 (2%)
Rathke's Cleft, Cyst 1 (2%) 2 (4%)
Rathke's Cleft, Hemorrhage 1 (2%) 2 (4%) 2 (4%) 6 (12%)
Rathke's Cleft, Hyperplasia, Cystic 1 (2%)
Thyroid Gland (47) (47) (43) (46)
Congestion 1 (2%)
Ultimobranchial Cyst 1 (2%) 1 (2%)
C-Cell, Hyperplasia 43 (91%) 45 (96%) 43 (100%) 44 (96%)
Follicle, Mineralization, Focal 25 (53%) 26 (55%) 40 (93%) 44 (96%)
Follicular Cell, Hyperplasia, Cystic, Focal 1 (2%)
Follicular Cell, Hypertrophy 3 (6%) 7 (15%) 27 (63%) 42 (91%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2) (4) (6)
Mediastinum, Cyst 1 (25%)
Mediastinum, Thrombosis 1 (17%)
Oral, Foreign Body, Focal 1 (17%)
Oral, Necrosis, Focal 1 (17%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (50) (49)
Cyst 1 (2%)
Degeneration, Cystic 5 (10%) 2 (4%) 6 (12%) 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Cystic 1 (2%) 4 (8%) 3 (6%) 1 (2%)
Hyperplasia, Cystic, Focal 1 (2%)
Inflammation, Chronic 6 (12%) 2 (4%) 1 (2%) 3 (6%)
Duct, Inflammation, Chronic 1 (2%)
Ovary (50) (50) (49) (50)
Cyst 5 (10%) 1 (2%) 1 (2%) 4 (8%)
Corpus Luteum, Hyperplasia 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%) 1 (2%)
Periovarian Tissue, Cyst 4 (8%) 4 (8%) 2 (4%) 1 (2%)
Uterus (50) (50) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hemorrhage 1 (2%) 1 (2%)
Hydrometra 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Focal, Suppurative 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Ulcer, Chronic Active 1 (2%)
Endometrium, Hyperplasia, Cystic 16 (32%) 7 (14%) 16 (33%) 11 (22%)
Vagina (6) (3) (3) (1)
Cyst 2 (33%) 1 (33%) 1 (33%) 1 (100%)
Inflammation, Chronic 1 (17%)
Inflammation, Suppurative 1 (33%) 1 (33%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (50)
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Hyperplasia, Focal, Histiocytic 2 (4%) 2 (4%)
Myeloid Cell, Hyperplasia 7 (14%) 3 (6%) 2 (4%) 6 (12%)
Myeloid Cell, Erythroid Cell, Hyperplasia 2 (4%) 2 (4%) 3 (6%)
Lymph Node (36) (34) (30) (39)
Hyperplasia, Plasma Cell 1 (3%)
Pigmentation 1 (3%)
Deep Cervical, Hemorrhage 1 (3%)
Deep Cervical, Hyperplasia, Lymphoid 1 (3%)
Deep Cervical, Hyperplasia, Plasma Cell 1 (3%)
Mediastinal, Angiectasis 1 (3%)
Mediastinal, Congestion 1 (3%)
Mediastinal, Ectasia 2 (6%) 4 (12%) 2 (7%) 4 (10%)
Mediastinal, Hemorrhage 6 (17%) 6 (18%) 5 (17%) 3 (8%)
Mediastinal, Hyperplasia, Histiocytic 1 (3%) 4 (12%) 2 (7%) 3 (8%)
Mediastinal, Hyperplasia, Lymphoid 1 (3%) 2 (6%) 2 (7%) 3 (8%)
Mediastinal, Hyperplasia, Plasma Cell 1 (3%)
Mediastinal, Infiltration Cellular, Mixed
Cell 1 (3%)
Mediastinal, Pigmentation 1 (3%)
Pancreatic, Angiectasis 1 (3%)
Pancreatic, Ectasia 1 (3%) 1 (3%)
Pancreatic, Hemorrhage 5 (14%) 3 (9%) 5 (13%)
Pancreatic, Hyperplasia, Histiocytic 31 (86%) 22 (65%) 15 (50%) 25 (64%)
Pancreatic, Hyperplasia, Lymphoid 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pancreatic, Pigmentation 1 (3%) 7 (21%) 3 (10%) 6 (15%)
Lymph Node, Mandibular (4) (6) (4) (5)
Ectasia 1 (17%)
Lymph Node, Mesenteric (50) (49) (49) (50)
Hemorrhage 1 (2%)
Hyperplasia, Focal, Histiocytic 1 (2%)
Hyperplasia, Histiocytic 2 (4%) 4 (8%) 4 (8%)
Hyperplasia, Lymphoid 1 (2%)
Spleen (50) (50) (50) (50)
Angiectasis, Focal 1 (2%) 1 (2%)
Fibrosis, Focal 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 16 (32%) 21 (42%) 8 (16%) 17 (34%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Focal, Histiocytic 2 (4%) 4 (8%) 2 (4%) 5 (10%)
Infarct 1 (2%)
Pigmentation, Focal 1 (2%)
Red Pulp, Fibrosis, Diffuse 1 (2%)
Thymus (49) (48) (48) (48)
Angiectasis 2 (4%) 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Dilatation 37 (74%) 39 (78%) 34 (68%) 38 (76%)
Ectasia 4 (8%) 1 (2%) 3 (6%) 2 (4%)
Fibrosis 2 (4%) 1 (2%) 1 (2%) 4 (8%)
Fibrosis, Focal 1 (2%)
Hyperplasia 7 (14%) 11 (22%) 10 (20%) 9 (18%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Skin (50) (50) (50) (50)
Inflammation, Chronic, Focal 1 (2%)
Ulcer 1 (2%)
Subcutaneous Tissue, Fibrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Compression, Focal 9 (18%) 9 (18%) 10 (20%) 9 (18%)
Hemorrhage, Focal 4 (8%) 3 (6%) 2 (4%)
Necrosis, Focal 1 (2%)
Thalamus, Mineralization, Focal 1 (2%)
Thalamus, Necrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 2 (4%) 1 (2%)
Hemorrhage, Focal 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Focal, Histiocytic 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Histiocytic 4 (8%) 6 (12%) 5 (10%) 2 (4%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Infiltration Cellular, Mixed Cell 2 (4%) 3 (6%) 2 (4%) 1 (2%)
Inflammation, Chronic, Focal 2 (4%) 4 (8%) 2 (4%)
Metaplasia, Focal, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 4 (8%) 2 (4%) 3 (6%) 2 (4%)
Interstitium, Edema 1 (2%)
Mediastinum, Edema 1 (2%)
Peribronchiolar, Hyperplasia, Lymphoid 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%) 2 (4%)
Nasolacrimal Duct, Inflammation 1 (2%) 1 (2%)
Respiratory Epithelium, Metaplasia, Focal,
Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (49) (47) (50)
Atrophy 1 (2%)
Cataract 2 (4%) 3 (6%) 1 (2%) 2 (4%)
Hemorrhage 1 (2%)
Retinal Detachment 1 (2%)
Bilateral, Atrophy 1 (2%)
Cornea, Inflammation, Chronic 1 (2%) 1 (2%)
Cornea, Necrosis, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Retina, Degeneration 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Harderian Gland (50) (50) (50) (50)
Hyperplasia, Cystic, Focal 1 (2%)
Hyperplasia, Focal 1 (2%)
Hyperplasia, Focal, Histiocytic 2 (4%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%) 2 (4%)
Metaplasia, Focal, Squamous 1 (2%)
Epithelium, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (47) (47)
Atrophy, Diffuse 1 (2%)
Atrophy, Focal 1 (2%) 2 (4%)
Cyst 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infarct 1 (2%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%)
Inflammation, Chronic, Focal, Granulomatous 1 (2%)
Nephropathy 43 (86%) 41 (84%) 37 (79%) 38 (81%)
Pelvis, Inflammation, Chronic 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%)
Renal Tubule, Accumulation, Hyaline Droplet 5 (10%) 12 (24%) 11 (23%) 5 (11%)
Renal Tubule, Pigmentation 2 (4%) 1 (2%) 4 (9%) 4 (9%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 10 13 11 14
Natural Death 3 10 8 8
Accidently Killed 1
Survivors
Terminal Sacrifice 36 27 31 28
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (47) (44) (49)
Edema 2 (4%)
Intestine Large, Rectum (48) (47) (47) (50)
Congestion 1 (2%)
Edema 1 (2%)
Hemorrhage 1 (2%)
Intestine Large, Cecum (47) (46) (43) (47)
Edema 1 (2%) 1 (2%)
Ulcer 1 (2%)
Intestine Small, Duodenum (49) (46) (46) (47)
Ulcer 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Intestine Small, Jejunum (47) (46) (42) (44)
Epithelium, Necrosis 1 (2%)
Intestine Small, Ileum (47) (46) (42) (47)
Ulcer 1 (2%)
Liver (50) (50) (48) (50)
Angiectasis, Focal 2 (4%) 1 (2%) 1 (2%) 3 (6%)
Basophilic Focus 27 (54%) 30 (60%) 33 (69%) 29 (58%)
Cholangiofibrosis 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Clear Cell Focus 21 (42%) 18 (36%) 29 (60%) 15 (30%)
Congestion 2 (4%)
Degeneration, Cystic, Focal 13 (26%) 9 (18%) 12 (25%) 14 (28%)
Eosinophilic Focus 2 (4%) 3 (6%) 2 (4%)
Fibrosis, Focal 1 (2%) 1 (2%)
Hemorrhage, Focal 1 (2%)
Hepatodiaphragmatic Nodule 6 (12%) 2 (4%) 3 (6%) 5 (10%)
Hyperplasia, Focal, Histiocytic 6 (12%) 2 (4%) 8 (17%) 5 (10%)
Hyperplasia, Focal, Lymphoid 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infarct 1 (2%)
Infiltration Cellular, Mixed Cell 36 (72%) 29 (58%) 33 (69%) 28 (56%)
Mixed Cell Focus 13 (26%) 11 (22%) 3 (6%) 8 (16%)
Bile Duct, Hyperplasia 48 (96%) 49 (98%) 46 (96%) 50 (100%)
Centrilobular, Congestion 1 (2%)
Hepatocyte, Necrosis, Focal 1 (2%) 2 (4%)
Hepatocyte, Vacuolization Cytoplasmic,
Diffuse 3 (6%) 3 (6%) 4 (8%)
Hepatocyte, Vacuolization Cytoplasmic, Focal 26 (52%) 15 (30%) 14 (29%) 18 (36%)
Hepatocyte, Periportal, Necrosis 1 (2%)
Hepatocyte, Periportal, Vacuolization
Cytoplasmic 1 (2%) 1 (2%)
Hepatocyte, Centrilobular, Atrophy 1 (2%)
Hepatocyte, Centrilobular, Necrosis 1 (2%) 3 (6%) 6 (13%) 4 (8%)
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 4 (8%) 9 (18%) 12 (25%) 11 (22%)
Hepatocyte, Midzonal, Necrosis 1 (2%)
Hepatocyte, Midzonal, Vacuolization
Cytoplasmic 6 (12%) 1 (2%) 1 (2%)
Hepatocyte, Midzonal, Vacuolization
Cytoplasmic, Focal 1 (2%)
Portal, Fibrosis 1 (2%)
Portal, Hemorrhage 1 (2%)
Mesentery (19) (20) (19) (23)
Angiectasis 1 (5%)
Hemorrhage 1 (5%) 1 (5%)
Inflammation, Chronic 1 (5%)
Inflammation, Chronic, Focal 1 (4%)
Fat, Necrosis 2 (11%) 2 (11%) 2 (9%)
Fat, Necrosis, Focal 12 (63%) 10 (50%) 13 (68%) 14 (61%)
Pancreas (49) (49) (49) (50)
Inflammation, Chronic 1 (2%)
Acinus, Atrophy, Diffuse 1 (2%)
Acinus, Atrophy, Focal 23 (47%) 23 (47%) 27 (55%) 15 (30%)
Acinus, Hyperplasia, Focal 1 (2%) 1 (2%)
Duct, Cyst, Focal 1 (2%) 1 (2%)
Duct, Cyst, Focal, Multiple 15 (31%) 13 (27%) 18 (37%) 15 (30%)
Salivary Glands (49) (50) (50) (50)
Atrophy 1 (2%)
Hyperplasia, Focal, Histiocytic 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Edema 1 (2%) 1 (2%) 4 (8%)
Erosion 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 4 (8%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Focal 1 (2%) 1 (2%)
Ulcer 1 (2%) 5 (10%) 2 (4%) 4 (8%)
Epithelium, Cyst 1 (2%)
Epithelium, Hyperplasia 2 (4%) 8 (16%) 1 (2%) 7 (14%)
Epithelium, Hyperplasia, Focal 1 (2%)
Stomach, Glandular (49) (48) (48) (50)
Erosion 3 (6%) 2 (4%) 4 (8%) 4 (8%)
Perforation 1 (2%)
Pigmentation, Focal 1 (2%) 1 (2%)
Ulcer 1 (2%) 3 (6%)
Epithelium, Hyperplasia, Focal 1 (2%)
Tongue (1) (1) (1) (1)
Epithelium, Hyperplasia 1 (100%)
Tooth (1) (1)
Malformation 1 (100%)
Peridontal Tissue, Hyperplasia, Squamous 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 6 (12%) 3 (6%) 7 (14%) 10 (20%)
Infiltration Cellular, Mixed Cell 2 (4%) 1 (2%) 2 (4%)
Inflammation, Chronic, Focal 1 (2%)
Thrombosis 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Artery, Inflammation, Chronic, Focal 1 (2%)
Endocardium, Valve, Inflammation, Chronic,
Focal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%) 7 (14%) 4 (8%) 3 (6%)
Atrophy 1 (2%)
Cytoplasmic Alteration, Focal 3 (6%) 3 (6%) 2 (4%) 4 (8%)
Degeneration, Cystic, Focal 2 (4%)
Hyperplasia, Diffuse 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Necrosis, Focal 1 (2%)
Vacuolization Cytoplasmic, Diffuse 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Vacuolization Cytoplasmic, Focal 12 (24%) 8 (16%) 7 (14%) 6 (12%)
Capsule, Fibrosis, Focal 1 (2%)
Adrenal Medulla (49) (49) (50) (50)
Hyperplasia, Focal 5 (10%) 12 (24%) 9 (18%) 13 (26%)
Islets, Pancreatic (50) (49) (49) (50)
Hyperplasia 2 (4%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Parathyroid Gland (49) (50) (47) (49)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (48) (50) (49) (50)
Angiectasis 2 (4%) 4 (8%) 1 (2%) 3 (6%)
Hemorrhage 1 (2%)
Hemorrhage, Focal 1 (2%)
Pars Distalis, Cyst 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Cytoplasmic Alteration, Focal 3 (6%) 7 (14%) 3 (6%) 8 (16%)
Pars Distalis, Degeneration, Cystic, Focal 2 (4%) 2 (4%)
Pars Distalis, Hemorrhage, Focal 2 (4%) 2 (4%) 1 (2%) 3 (6%)
Pars Distalis, Hyperplasia, Focal 4 (8%) 2 (4%) 3 (6%) 1 (2%)
Pars Distalis, Pars Nervosa, Hemorrhage,
Focal 1 (2%)
Pars Intermedia, Hemorrhage, Focal 1 (2%)
Rathke's Cleft, Cyst 1 (2%)
Rathke's Cleft, Hemorrhage 1 (2%) 2 (4%) 2 (4%)
Rathke's Cleft, Hyperplasia, Cystic 1 (2%)
Thyroid Gland (47) (44) (43) (47)
C-Cell, Hyperplasia 45 (96%) 42 (95%) 41 (95%) 44 (94%)
C-Cell, Hyperplasia, Focal 1 (2%)
Follicle, Cyst 1 (2%) 1 (2%) 2 (4%)
Follicle, Degeneration, Cystic, Focal 2 (4%)
Follicle, Mineralization, Focal 45 (96%) 43 (98%) 42 (98%) 42 (89%)
Follicular Cell, Hypertrophy 4 (9%) 13 (30%) 33 (77%) 40 (85%)
Follicular Cell, Hypertrophy, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (5) (6) (2) (7)
Abdominal, Fibrosis 1 (50%)
Mediastinum, Hemorrhage 1 (17%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Epididymis (50) (50) (50) (50)
Fibrosis 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 2 (4%)
Penis (2)
Thrombosis 1 (50%)
Preputial Gland (48) (49) (50) (50)
Atrophy 1 (2%)
Cyst 1 (2%) 1 (2%)
Degeneration, Cystic 2 (4%) 1 (2%) 2 (4%)
Hyperplasia, Cystic 1 (2%) 1 (2%)
Inflammation, Chronic 22 (46%) 12 (24%) 18 (36%) 20 (40%)
Necrosis 1 (2%)
Prostate (50) (49) (50) (50)
Inflammation, Chronic 21 (42%) 23 (47%) 29 (58%) 30 (60%)
Mineralization, Focal 3 (6%) 2 (4%) 3 (6%) 4 (8%)
Epithelium, Hyperplasia, Focal 11 (22%) 4 (8%) 2 (4%) 11 (22%)
Testes (50) (50) (50) (50)
Atrophy 4 (8%) 10 (20%) 9 (18%) 6 (12%)
Bilateral, Atrophy 1 (2%)
Germinal Epithelium, Atrophy 1 (2%)
Germinal Epithelium, Degeneration 1 (2%)
Interstitial Cell, Hyperplasia, Focal 1 (2%) 1 (2%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (48) (50) (49)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Fibrosis 2 (4%)
Hyperplasia 28 (58%) 35 (73%) 41 (82%) 40 (82%)
Myeloid Cell, Erythroid Cell, Hyperplasia 2 (4%)
Lymph Node (34) (24) (26) (34)
Ectasia 1 (3%)
Hemorrhage 1 (3%)
Deep Cervical, Hemorrhage 1 (4%)
Deep Cervical, Hyperplasia, Plasma Cell 1 (3%)
Mediastinal, Angiectasis 1 (4%)
Mediastinal, Ectasia 5 (15%) 7 (29%) 5 (19%) 3 (9%)
Mediastinal, Hemorrhage 3 (9%) 2 (8%) 2 (8%) 1 (3%)
Mediastinal, Hyperplasia, Histiocytic 3 (13%) 2 (8%) 1 (3%)
Mediastinal, Hyperplasia, Lymphoid 1 (3%) 1 (4%) 3 (9%)
Mediastinal, Hyperplasia, Plasma Cell 1 (3%) 2 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Infiltration Cellular,
Polymorphonuclear 1 (4%)
Mediastinal, Inflammation, Chronic Active 1 (3%)
Mediastinal, Inflammation, Suppurative 1 (4%)
Pancreatic, Angiectasis 2 (6%)
Pancreatic, Ectasia 3 (9%) 3 (13%) 3 (12%) 6 (18%)
Pancreatic, Hemorrhage 5 (15%) 3 (13%) 1 (4%) 1 (3%)
Pancreatic, Hyperplasia, Histiocytic 8 (24%) 5 (21%) 9 (35%) 6 (18%)
Pancreatic, Hyperplasia, Lymphoid 1 (3%) 1 (4%)
Pancreatic, Pigmentation 1 (3%) 1 (4%) 1 (4%)
Renal, Hemorrhage 1 (4%)
Renal, Hyperplasia, Focal, Histiocytic 1 (4%)
Renal, Hyperplasia, Lymphoid 1 (4%)
Lymph Node, Mesenteric (49) (50) (49) (50)
Amyloid Deposition 1 (2%)
Ectasia 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Hemorrhage 2 (4%) 3 (6%)
Hyperplasia, Focal, Histiocytic 1 (2%)
Hyperplasia, Histiocytic 3 (6%) 3 (6%) 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%) 1 (2%)
Spleen (48) (49) (49) (50)
Amyloid Deposition 1 (2%)
Angiectasis, Focal 2 (4%) 1 (2%) 3 (6%)
Atrophy 1 (2%)
Congestion 1 (2%) 1 (2%)
Fibrosis, Focal 2 (4%) 2 (4%) 4 (8%)
Hematopoietic Cell Proliferation 2 (4%) 6 (12%) 4 (8%) 11 (22%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Focal, Histiocytic 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Infarct, Multiple 1 (2%)
Metaplasia, Focal, Lipocyte 1 (2%)
Necrosis 1 (2%)
Pigmentation 1 (2%)
Pigmentation, Focal 1 (2%)
Capsule, Accessory Spleen, Focal 1 (2%)
Capsule, Fibrosis, Focal 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%)
Thymus (48) (48) (49) (47)
Angiectasis 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 3 (6%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (43) (47) (44)
Cyst 1 (2%)
Dilatation 7 (16%) 7 (16%) 7 (15%) 2 (5%)
Hyperplasia 1 (2%) 2 (4%) 2 (5%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 3 (6%) 1 (2%) 3 (6%) 1 (2%)
Fibrosis, Focal 2 (4%)
Hyperkeratosis, Focal 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 2 (4%)
Ulcer 1 (2%)
Artery, Subcutaneous Tissue, Thrombosis 1 (2%)
Epidermis, Hyperplasia, Focal 1 (2%)
Lip, Inflammation, Chronic, Focal 1 (2%)
Subcutaneous Tissue, Cyst 1 (2%)
Subcutaneous Tissue, Cyst Epithelial
Inclusion 1 (2%)
Subcutaneous Tissue, Hyperplasia, Focal,
Histiocytic 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Cranium, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression, Focal 6 (12%) 6 (12%) 7 (14%) 6 (12%)
Hemorrhage, Focal 2 (4%) 2 (4%) 4 (8%) 6 (12%)
Cerebrum, Ventricle, Hydrocephalus 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Lung (50) (50) (50) (50)
Congestion 2 (4%) 1 (2%) 3 (6%)
Foreign Body, Focal 1 (2%)
Hemorrhage 1 (2%)
Hemorrhage, Focal 3 (6%) 1 (2%) 2 (4%) 2 (4%)
Hyperplasia, Focal, Histiocytic 1 (2%) 1 (2%)
Hyperplasia, Histiocytic 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Infiltration Cellular, Mixed Cell 1 (2%) 3 (6%) 1 (2%) 2 (4%)
Inflammation, Chronic, Focal 5 (10%) 2 (4%) 3 (6%) 3 (6%)
Inflammation, Focal, Suppurative 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 8 (16%) 5 (10%) 3 (6%) 4 (8%)
Alveolar Epithelium, Metaplasia, Squamous 1 (2%)
Alveolus, Edema, Focal 1 (2%)
Alveolus, Hyperplasia, Focal, Histiocytic 1 (2%)
Interstitium, Edema 1 (2%) 1 (2%)
Mediastinum, Edema 1 (2%) 1 (2%)
Nose (49) (49) (49) (50)
Foreign Body 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 6 (12%) 1 (2%)
Nasolacrimal Duct, Inflammation 1 (2%) 3 (6%) 1 (2%)
Olfactory Epithelium, Hyperplasia, Focal 1 (2%)
Respiratory Epithelium, Hyperplasia, Focal 1 (2%)
Trachea (50) (49) (50) (50)
Peritracheal Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (48) (46) (50)
Atrophy 2 (4%)
Cataract 2 (4%) 1 (2%) 2 (4%)
Exudate 1 (2%)
Cornea, Inflammation, Chronic 1 (2%)
Cornea, Retrobulbar, Inflammation, Chronic
Active 1 (2%)
Retina, Degeneration 2 (4%) 1 (2%) 2 (4%)
Harderian Gland (49) (49) (49) (50)
Fibrosis, Focal 1 (2%)
Hyperplasia, Focal, Histiocytic 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active, Diffuse 1 (2%)
Epithelium, Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:20:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (47) (46) (49) (49)
Cyst 1 (2%)
Cyst, Multiple 1 (2%)
Hydronephrosis 1 (2%)
Infarct 1 (2%)
Infarct, Multiple 1 (2%) 1 (2%)
Metaplasia, Focal, Lipocyte 1 (2%)
Nephropathy 45 (96%) 44 (96%) 48 (98%) 47 (96%)
Cortex, Medulla, Atrophy 1 (2%)
Pelvis, Infiltration Cellular, Mixed Cell 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) 4 (8%) 2 (4%)
Renal Tubule, Hyperplasia, Focal 1 (2%)
Renal Tubule, Pigmentation 4 (9%) 4 (9%) 1 (2%) 4 (8%)
Urinary Bladder (48) (49) (47) (50)
Calculus Micro Observation Only 1 (2%)
Edema 2 (4%)
Hemorrhage 2 (4%)
Inflammation, Chronic 1 (2%)
Serosa, Inflammation, Focal 1 (2%)
Transitional Epithelium, Hyperplasia, Diffuse 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
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