TDMS Study 96010-03 Pathology Tables
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
FINAL#1/RATS
Facility: Southern Research Institute
Chemical CAS #: 7775-09-9
Lock Date: 10/16/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|
| 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X|
Cholangiofibrosis | |
Clear Cell Focus | X X X X|
Congestion | 2 2 2|
Degeneration, Cystic, Focal | |
Hemorrhage | 2 |
Hepatodiaphragmatic Nodule | 3 3|
Hyperplasia, Focal, Histiocytic | 1 1 1 2 1 3 1 1 3 3 1|
Hyperplasia, Focal, Regenerative | 4|
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 |
Mixed Cell Focus | X X X X X |
Bile Duct, Hyperplasia | 1 2 2 1 1 1 2 1 1 2 1 1 2 2|
Capsule, Cyst | 3 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 1 1 2 1 2 1 1 1 3|
Hepatocyte, Centrilobular, Necrosis | 2 |
Hepatocyte, Centrilobular, | |
Vacuolization Cytoplasmic | |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|
| 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Necrosis, Focal | 2 2 2 2 3 |
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 1 1 1 4|
Duct, Cyst, Focal | 1 |
Duct, Cyst, Focal, Multiple | 1 2 1 1 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Erosion | 2 |
Pigmentation, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 |
Angiectasis | |
Cytoplasmic Alteration, Focal | |
Hemorrhage | |
Vacuolization Cytoplasmic, Focal | 2 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|
| 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + M + + + + + + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Angiectasis | 2 3 2 3 3 |
Pigmentation, Focal | |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 3 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 |
Pars Distalis, Degeneration, Cystic, | |
Focal | 1 2 1 1 2 |
Pars Distalis, Hemorrhage, Focal | 3 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 3 2 2 |
Rathke's Cleft, Cyst | |
Rathke's Cleft, Hemorrhage | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 3 3 2 3 3 2 1 2 2 3 2 1 2 3 2 2 2 1 2 2 2 3|
Follicle, Mineralization, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1|
Follicular Cell, Hyperplasia, Cystic,| |
Focal | |
Follicular Cell, Hypertrophy | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Degeneration, Cystic | 3 3 3 3 |
Hyperplasia, Cystic | |
Inflammation, Chronic | 3 1 3 |
Duct, Inflammation, Chronic | 4 |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|
| 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 1 2 |
Periovarian Tissue, Cyst | 3 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 |
Endometrium, Hyperplasia, Cystic | 2 1 2 1 3|
|__________________________________________________________________________|
Vagina | + + |
Cyst | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Myeloid Cell, Hyperplasia | 3 2 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 |
Deep Cervical, Hemorrhage | |
Deep Cervical, Hyperplasia, Lymphoid | 3 |
Mediastinal, Congestion | |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | 3 3 |
Mediastinal, Hyperplasia, Histiocytic| |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Ectasia | |
Pancreatic, Hemorrhage | 3 3 |
Pancreatic, Hyperplasia, Histiocytic | 3 3 1 2 1 2 3 1 1 3 1 1 2 2|
Pancreatic, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M + M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|
| 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 2 3 4 2 2 3 |
Hemorrhage | |
Hyperplasia, Focal, Histiocytic | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 3 3 2 4 4 4 2 4 3 2 4 2 2 4 2 2|
Ectasia | 3 2 |
Fibrosis, Focal | |
Fibrosis | 2 |
Hyperplasia, Focal | 3 |
Hyperplasia | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 4 3 3 2 3 |
Thalamus, Mineralization, Focal | |
Thalamus, Necrosis, Focal | |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|
| 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Hyperplasia, Focal, Histiocytic | 2 |
Hyperplasia, Histiocytic | 2 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic, Focal | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cataract | 3 2 |
Retinal Detachment | |
Cornea, Inflammation, Chronic | |
Cornea, Necrosis, Focal | |
Retina, Degeneration | 4 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Focal | 2 |
Hyperplasia, Focal, Histiocytic | 3 2 |
Epithelium, Hyperplasia, Focal | 1 |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Inflammation, Chronic | 2 |
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 6| 3| 3| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 3| 3|
| 4| 4| 5| 4| 1| 6| 6| 6| 6| 1| 7| 4| 4| 4| 4| 6| 6| 2| 6| 6| 4| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 3 2 |
Renal Tubule, Pigmentation | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 8
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3| |
| 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 42 |
Cholangiofibrosis | 4 | 1 4.0|
Clear Cell Focus | X X | 6 |
Congestion | 2 2 2 | 6 2.0|
Degeneration, Cystic, Focal | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
Hepatodiaphragmatic Nodule | 3 2 3 2 3 | 7 2.7|
Hyperplasia, Focal, Histiocytic | 3 3 1 1 1 1 1 2 1| 20 1.6|
Hyperplasia, Focal, Regenerative | | 1 4.0|
Infiltration Cellular, Mixed Cell | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2| 39 1.9|
Mixed Cell Focus | X X X X X X X | 12 |
Bile Duct, Hyperplasia | 2 2 2 1 2 1 1 2 1 3 1 1 2 1 1| 29 1.5|
Capsule, Cyst | | 1 3.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | | 1 2.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 1 1 1 3 1 2 1 | 17 1.5|
Hepatocyte, Centrilobular, Necrosis | 2 | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3| |
| 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | 3 4 2 4 2 | 5 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + | 18 |
Fat, Necrosis, Focal | 3 3 2 2 2 2 3 | 12 2.3|
Fat, Necrosis | 3 2 2 | 4 2.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | 2 2 1 1 1 1 1 1 2 1 | 15 1.4|
Duct, Cyst, Focal | | 1 1.0|
Duct, Cyst, Focal, Multiple | 2 1 1 2 1 | 10 1.4|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 | 2 2.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion, Focal | 2 | 1 2.0|
Erosion | 2 | 2 2.0|
Pigmentation, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 | 4 1.5|
Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 2 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3| |
| 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Angiectasis | 2 3 | 2 2.5|
Cytoplasmic Alteration, Focal | 2 | 1 2.0|
Hemorrhage | 3 | 1 3.0|
Vacuolization Cytoplasmic, Focal | 1 2 2 1 | 7 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 3 2 3 2 | 10 2.5|
Pigmentation, Focal | 2 | 1 2.0|
Pars Distalis, Angiectasis | 3| 1 3.0|
Pars Distalis, Cyst | 2 | 2 2.5|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 1 | 3 1.0|
Pars Distalis, Degeneration, Cystic, | | |
Focal | 2 3 2 2 2 3 | 11 1.9|
Pars Distalis, Hemorrhage, Focal | 3 2 3 3 | 9 2.9|
Pars Distalis, Hyperplasia, Focal | 3 2 2 2| 7 2.3|
Rathke's Cleft, Cyst | 2 | 1 2.0|
Rathke's Cleft, Hemorrhage | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + A + + +| 47 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia | 3 2 2 2 1 2 3 3 2 2 2 2 3 2 2 2 3 1 2 2 3| 43 2.2|
Follicle, Mineralization, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 | 25 1.0|
Follicular Cell, Hyperplasia, Cystic,| | |
Focal | 2 | 1 2.0|
Follicular Cell, Hypertrophy | 1 2 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3| |
| 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Cyst | | 1 4.0|
Degeneration, Cystic | 3| 5 3.0|
Hyperplasia, Cystic | 3 | 1 3.0|
Inflammation, Chronic | 3 4 3 | 6 2.8|
Duct, Inflammation, Chronic | | 1 4.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 5 2.2|
Periovarian Tissue, Cyst | 3 3 | 4 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 1 1 2 2 1 2 1 3 2 2| 16 1.8|
|__________________________________________________________________________|____________|
Vagina | + + + + | 6 |
Cyst | 3 3 | 2 3.0|
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 2 3.5|
Myeloid Cell, Hyperplasia | 2 2 3 3 | 7 2.4|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +| 36 |
Hyperplasia, Plasma Cell | | 1 3.0|
Deep Cervical, Hemorrhage | 2 | 1 2.0|
Deep Cervical, Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3| |
| 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mediastinal, Congestion | 3 | 1 3.0|
Mediastinal, Ectasia | 3 3 | 2 3.0|
Mediastinal, Hemorrhage | 3 3 3 3 | 6 3.0|
Mediastinal, Hyperplasia, Histiocytic| 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Pancreatic, Ectasia | 2 | 1 2.0|
Pancreatic, Hemorrhage | 3 3 3 | 5 3.0|
Pancreatic, Hyperplasia, Histiocytic | 2 3 1 3 2 2 1 1 3 1 2 2 2 2 2 1 1| 31 1.8|
Pancreatic, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M + M M M M M M M M M M M M + M M +| 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Histiocytic | 3 | 2 3.0|
Hyperplasia, Lymphoid | 3| 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 | 16 2.4|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Focal, Histiocytic | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 2 | 2 2.5|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 4 3 4 4 2 4 4 4 3 4 4 3 3 3 4 4 4| 37 3.1|
Ectasia | 2 4 | 4 2.8|
Fibrosis, Focal | 2 | 1 2.0|
Fibrosis | 3 | 2 2.5|
Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3| |
| 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Hyperplasia | 2 2 3 3 3 2| 7 2.4|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Compression, Focal | 2 2 3 2 | 9 2.7|
Thalamus, Mineralization, Focal | 3 | 1 3.0|
Thalamus, Necrosis, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 2 | 1 2.0|
Hyperplasia, Focal, Histiocytic | | 1 2.0|
Hyperplasia, Histiocytic | 2 1 | 4 1.8|
Infiltration Cellular, Mixed Cell | 3 | 2 2.5|
Inflammation, Chronic, Focal | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 2 | 4 1.5|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 5| 6| 5| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 1| 3| 3| 3| 3| 3| 9| 3| 3| 3| 1| 3| 2| 3| 3| 6| 4| 9| 3| 3| 3| |
| 5| 3| 5| 5| 8| 7| 7| 7| 7| 7| 4| 4| 4| 4| 7| 7| 3| 7| 7| 6| 4| 5| 4| 4| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Cataract | | 2 2.5|
Retinal Detachment | 3 | 1 3.0|
Cornea, Inflammation, Chronic | 4 | 1 4.0|
Cornea, Necrosis, Focal | 4 | 1 4.0|
Retina, Degeneration | | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic, Focal | | 1 2.0|
Hyperplasia, Focal, Histiocytic | | 2 2.5|
Epithelium, Hyperplasia, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 3 | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 2 1| 43 1.1|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 3 | 5 2.6|
Renal Tubule, Pigmentation | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X |
Congestion | 2 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | 3 |
Hyperplasia, Focal, Histiocytic | 2 1 1 2 1 1 3 3 1 1 1 |
Infarct, Multiple | |
Infiltration Cellular, | |
Polymorphonuclear | 3 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 |
Mixed Cell Focus | X X X |
Thrombosis | |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 1 1 2 |
Hepatocyte, Karyomegaly | |
Hepatocyte, Necrosis, Focal | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | 3 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 1 2 |
Hepatocyte, Periportal, | |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Vacuolization Cytoplasmic | |
Hepatocyte, Centrilobular, Necrosis | |
Hepatocyte, Centrilobular, | |
Vacuolization Cytoplasmic | 3|
Hepatocyte, Midzonal, Vacuolization | |
Cytoplasmic | 4 |
|__________________________________________________________________________|
Mesentery | + + + +|
Inflammation, Chronic, Focal | |
Fat, Necrosis, Focal | 3 3 3 |
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 3 3 2 |
Duct, Cyst, Focal | 1 |
Duct, Cyst, Focal, Multiple | 2 2 2 1 2 2 2 1 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Inflammation, Chronic | 2 |
Ulcer | 2 3 2 3|
Epithelium, Hyperplasia | 2 3|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Necrosis, Focal | |
Ulcer | 2 |
|__________________________________________________________________________|
Tooth | |
Dentine, Malformation | |
Peridontal Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Blood Vessel | |
Thrombosis | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 |
Infiltration Cellular, Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | 3 |
Cytoplasmic Alteration, Focal | 3 1 |
Degeneration, Cystic, Focal | 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Infiltration Cellular, Mixed Cell | |
Necrosis, Focal | 3 |
Vacuolization Cytoplasmic, Focal | 1 1 1 2 3 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | 3 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
Pars Distalis, Degeneration, Cystic, | |
Focal | 1 1 2 2 |
Pars Distalis, Hemorrhage, Focal | 2 3 3 4|
Pars Distalis, Hyperplasia, Focal | 2 2 3 |
Pars Nervosa, Hyperplasia, Atypical, | |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Focal | |
Rathke's Cleft, Cyst | 2 |
Rathke's Cleft, Hemorrhage | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 2 3 2 1 1 2 2 3 2 2 2 2 3 3 2 2 2 2 3 1|
Follicle, Mineralization, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Follicular Cell, Hypertrophy | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Hyperplasia, Cystic, Focal | |
Hyperplasia, Cystic | 3 3 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Interstitial Cell, Hyperplasia | 2 |
Periovarian Tissue, Cyst | 3 3 3 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Suppurative | 3 |
Endometrium, Hyperplasia, Cystic | 1 |
|__________________________________________________________________________|
Vagina | + + |
Cyst | |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia | 1 |
Myeloid Cell, Hyperplasia | 2 3 |
Myeloid Cell, Erythroid Cell, | |
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
Mediastinal, Ectasia | 3 |
Mediastinal, Hemorrhage | 3 3 |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Plasma Cell| |
Pancreatic, Angiectasis | |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia, Histiocytic | 2 2 3 1 3 2 3 2 2 |
Pancreatic, Pigmentation | 1 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M + + M M M M M M M M M M M M M M M + M + M M M|
Ectasia | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 2 3 4 2 2 2 2 2 2 2 |
Hemorrhage | 2 |
Hyperplasia, Focal, Histiocytic | 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 3 2 2 3 2 4 2 3 4 4 4 4 2 2 4 4 4 3 4 4 2 3|
Ectasia | 2 |
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Fibrosis | |
Hyperplasia | 1 3 3 3 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 3 2 3 2 |
Hemorrhage, Focal | 3 2 |
Necrosis, Focal | 3 |
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Histiocytic | |
Hyperplasia, Histiocytic | 1 2 |
Infiltration Cellular, | |
Polymorphonuclear | 3 |
Infiltration Cellular, Mixed Cell | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Nasolacrimal Duct, Inflammation | 2|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 4| 3| 2| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
| 4| 4| 4| 6| 4| 6| 3| 3| 6| 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 3 1 |
Hemorrhage | 3 |
Cornea, Inflammation, Chronic | 3 |
Retina, Degeneration | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 4 |
Infarct | |
Infiltration Cellular, | |
Polymorphonuclear | 3 |
Inflammation, Chronic | |
Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 3 1 1 1 1|
Pelvis, Inflammation, Chronic | 3 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 2 2 2 2 2 2 2 |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 22
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A A + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 44 |
Clear Cell Focus | X X X X X X X X | 16 |
Congestion | 4 | 2 3.0|
Eosinophilic Focus | X | 1 |
Hepatodiaphragmatic Nodule | 3 3 3 | 4 3.0|
Hyperplasia, Focal, Histiocytic | 3 1 3 3 2 1 1 2 | 19 1.7|
Infarct, Multiple | 3 | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Infiltration Cellular, Mixed Cell | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 1 2 2| 38 1.9|
Mixed Cell Focus | X X X | 6 |
Thrombosis | 3 | 1 3.0|
Bile Duct, Cyst | 2 | 1 2.0|
Bile Duct, Hyperplasia | 3 2 3 2 2 1 3 1 1 1 3 | 24 1.5|
Hepatocyte, Karyomegaly | 3 | 1 3.0|
Hepatocyte, Necrosis, Focal | 2 1 | 2 1.5|
Hepatocyte, Vacuolization | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Cytoplasmic, Diffuse | | 2 2.5|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 1 2 2 1 2 2 | 10 1.7|
Hepatocyte, Periportal, | | |
Vacuolization Cytoplasmic | 1 3 | 2 2.0|
Hepatocyte, Centrilobular, Necrosis | 4 | 1 4.0|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | 3 3 | 3 3.0|
Hepatocyte, Midzonal, Vacuolization | | |
Cytoplasmic | 3 | 2 3.5|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 10 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
Fat, Necrosis, Focal | 3 1 | 5 2.6|
Fat, Necrosis | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | 2 1 2 2 | 8 2.1|
Duct, Cyst, Focal | 1 | 2 1.0|
Duct, Cyst, Focal, Multiple | 1 2 2 2 2 | 14 1.8|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Erosion | 2 | 1 2.0|
Inflammation, Chronic | 3 | 2 2.5|
Ulcer | 2 2 3 | 7 2.4|
Epithelium, Hyperplasia | 3 1 | 4 2.3|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 1 2.0|
Necrosis, Focal | 2 | 1 2.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
Dentine, Malformation | 3 | 1 3.0|
Peridontal Tissue, Inflammation, | | |
Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Thrombosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 2 2.5|
Infiltration Cellular, Mixed Cell | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 1 2 | 3 1.3|
Angiectasis | | 1 3.0|
Cytoplasmic Alteration, Focal | | 2 2.0|
Degeneration, Cystic, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Necrosis, Focal | | 1 3.0|
Vacuolization Cytoplasmic, Focal | 2 2 1 3 1 1 1 | 13 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 2| 4 1.3|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + M + + +| 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 2 3 3 2 4 | 6 2.8|
Pars Distalis, Angiectasis | 3 | 2 2.5|
Pars Distalis, Cyst | 2 | 2 2.5|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 | 1 1.0|
Pars Distalis, Degeneration, Cystic, | | |
Focal | 1 1 2 2 2 2 2 2 2 3 | 14 1.8|
Pars Distalis, Hemorrhage, Focal | 3 2 | 6 2.8|
Pars Distalis, Hyperplasia, Focal | 2 3 | 5 2.4|
Pars Nervosa, Hyperplasia, Atypical, | | |
Focal | 3 | 1 3.0|
Rathke's Cleft, Cyst | 3 | 2 2.5|
Rathke's Cleft, Hemorrhage | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A A + + + + + + + + + + + + + + + + + +| 47 |
C-Cell, Hyperplasia | 2 3 2 2 2 2 1 1 2 2 1 2 2 2 1 3 3 2 3 1 3 1 3| 45 2.1|
Follicle, Mineralization, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 | 26 1.0|
Follicular Cell, Hypertrophy | 1 1 | 7 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 | 2 3.0|
Hyperplasia, Cystic, Focal | 2 | 1 2.0|
Hyperplasia, Cystic | 2 2 | 4 2.5|
Inflammation, Chronic | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Cyst | | 1 3.0|
Interstitial Cell, Hyperplasia | | 1 2.0|
Periovarian Tissue, Cyst | | 4 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 1 2 1 1 2| 7 1.4|
|__________________________________________________________________________|____________|
Vagina | + | 3 |
Cyst | 3 | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
Myeloid Cell, Hyperplasia | 3| 3 2.7|
Myeloid Cell, Erythroid Cell, | | |
Hyperplasia | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + +| 34 |
Mediastinal, Ectasia | 3 3 3 | 4 3.0|
Mediastinal, Hemorrhage | 3 3 3 3| 6 3.0|
Mediastinal, Hyperplasia, Histiocytic| 3 3 3 | 4 3.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 2 2.5|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
Pancreatic, Angiectasis | 3 | 1 3.0|
Pancreatic, Hemorrhage | 2 4 3 | 3 3.0|
Pancreatic, Hyperplasia, Histiocytic | 2 3 2 3 2 2 3 1 2 2 2 2 2 | 22 2.2|
Pancreatic, Pigmentation | 3 1 1 2 2 | 7 1.6|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M + M M M| 6 |
Ectasia | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Histiocytic | 3 3 3 | 4 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 3 | 1 3.0|
Fibrosis, Focal | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 3 2 4 2 2 3 2 2 3| 21 2.4|
Hemorrhage | | 1 2.0|
Hyperplasia, Focal, Histiocytic | 4 3 | 4 2.8|
|__________________________________________________________________________|____________|
Thymus | + + + + + + A + + + + + + + + + + + + + + + + M +| 48 |
Angiectasis | 2 | 1 2.0|
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 3 2 4 3 2 2 2 4 2 2 3 4 4 3 4| 39 3.1|
Ectasia | | 1 2.0|
Fibrosis | 3 | 1 3.0|
Hyperplasia | 2 2 2 2 2 2 | 11 2.2|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + +| 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 3 3 4 | 9 2.9|
Hemorrhage, Focal | 2 2 | 4 2.3|
Necrosis, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Histiocytic | 2 | 1 2.0|
Hyperplasia, Histiocytic | 1 1 2 1 | 6 1.3|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 2| 3 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 2 2.0|
Nasolacrimal Duct, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Cataract | 3 | 3 2.3|
Hemorrhage | | 1 3.0|
Cornea, Inflammation, Chronic | | 1 3.0|
Retina, Degeneration | 3 | 2 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 6| 7| 6| 6| 3| 9| 6| 6| 6| 3| 1| 5| 5| 3| 5| 5| 5| 5| 6| 7| 7| 7| 4| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Atrophy, Diffuse | | 1 4.0|
Infarct | 3 | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Inflammation, Chronic | 3 1 | 2 2.0|
Nephropathy | 1 1 1 1 2 1 1 1 4 2 1 1 1 1 1 2 1 1 1 1 1| 41 1.2|
Pelvis, Inflammation, Chronic | | 1 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 2.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 1 3 2 2 | 12 2.0|
Renal Tubule, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + M + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|
| 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + A A|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + A A|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + A A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X |
Cholangiofibrosis | 4 |
Clear Cell Focus | X X X X X X X X X |
Congestion | 3 |
Degeneration, Cystic, Focal | |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | 2 3 2 2 3|
Hyperplasia, Focal, Histiocytic | 1 2 2 1 1 1 1 |
Infiltration Cellular, Focal, | |
Polymorphonuclear | 2 |
Infiltration Cellular, Mixed Cell | 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 2 3 |
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 1 1 1 3 2 2 1 1 2 1 2 3 1 2 1 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 2 2 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Hepatocyte, Periportal, | |
Centrilobular, Vacuolization | |
Cytoplasmic | |
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|
| 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hepatocyte, Centrilobular, Necrosis | 3 |
Hepatocyte, Centrilobular, | |
Vacuolization Cytoplasmic | 4 3 4 3 3|
|__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis, Focal | 2 3 3 3 |
Fat, Necrosis | |
|__________________________________________________________________________|
Oral Mucosa | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 3 1 2 2 1 |
Duct, Cyst, Focal | 1 1 |
Duct, Cyst, Focal, Multiple | 1 2 2 1 3 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Inflammation, Chronic, Focal | |
Inflammation, Chronic | |
Perforation | 3 |
Epithelium, Hyperplasia | 2 3 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +|
Erosion | |
|__________________________________________________________________________|
Tooth | |
Malformation | |
Peridontal Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|
| 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 |
Angiectasis | |
Cytoplasmic Alteration, Focal | |
Fibrosis, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 1 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Pars Distalis, Angiectasis | 4|
Pars Distalis, Cyst | 3 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 1 |
Pars Distalis, Degeneration, Cystic, | |
Focal | 3 2 2 2 3 1 3 2 |
Pars Distalis, Hemorrhage, Focal | 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 3 2 4 2 |
Pars Distalis, Infiltration Cellular,| |
Focal | |
Rathke's Cleft, Hemorrhage | 2 3 |
Rathke's Cleft, Hyperplasia, Cystic | |
|__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + + + + A + + + + + A A|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 3 2 2 2 2 3 2 1 3 3 3 3 2 3 3 3 3 2 2 3 3 |
Follicle, Mineralization, Focal | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 2 1 1 1 1 2 |
Follicular Cell, Hypertrophy | 1 1 1 1 1 1 2 2 1 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|
| 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Cyst | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 3 3 |
Hyperplasia, Cystic | 3 2 |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Interstitial Cell, Hyperplasia | 3 |
Periovarian Tissue, Cyst | 4 |
|__________________________________________________________________________|
Oviduct | + + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Endometrium, Hyperplasia, Cystic | 2 2 1 1 2 2 1 2|
|__________________________________________________________________________|
Vagina | |
Cyst | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Focal, Histiocytic | |
Hyperplasia | 2 |
Myeloid Cell, Hyperplasia | 2 |
Myeloid Cell, Erythroid Cell, | |
Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|
| 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | 3 3 3 |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Infiltration Cellular, | |
Mixed Cell | |
Mediastinal, Pigmentation | |
Pancreatic, Hyperplasia, Histiocytic | 3 2 3 3 3 2 2 2 3 |
Pancreatic, Hyperplasia, Lymphoid | 1 |
Pancreatic, Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M + M M M + + M M M M + M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Focal, Histiocytic | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 4 |
Hemorrhage | |
Hyperplasia, Focal, Histiocytic | |
Pigmentation, Focal | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2 2 4 2 2 2 4 3 2 4 4 4 4 4 2 |
Ectasia | |
Fibrosis | |
Hyperplasia | 2 2 3 2 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|
| 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 2 2 3 3 3 3 |
Hemorrhage, Focal | 1 2|
|__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Hemorrhage, Focal | 3 |
Hyperplasia, Histiocytic | 2 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Chronic, Focal | 2 2 |
Metaplasia, Focal, Osseous | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 2 |
Mediastinum, Edema | 3 |
Peribronchiolar, Hyperplasia, | |
Lymphoid | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + A|
Cataract | |
Retina, Degeneration | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Histiocytic | |
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 7| 1|
| 6| 6| 6| 4| 6| 6| 7| 7| 6| 7| 9| 3| 7| 7| 7| 6| 6| 7| 6| 1| 6| 6| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Inflammation, Chronic, Focal | 1 |
Metaplasia, Focal, Squamous | |
|__________________________________________________________________________|
Lacrimal Gland | + |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A +|
Cyst | 2|
Hyperplasia, Lymphoid | 2 |
Infarct | 3 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 2 1 1 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 2 2 2 2 |
Renal Tubule, Pigmentation | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 37
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0| |
| 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + A +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + A +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + A + + A +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + A + + A +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + A + + A +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + A + + A +| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 2 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 41 |
Cholangiofibrosis | | 1 4.0|
Clear Cell Focus | X X X X X X X X X | 18 |
Congestion | 2 | 2 2.5|
Degeneration, Cystic, Focal | 2 | 1 2.0|
Eosinophilic Focus | | 1 |
Hepatodiaphragmatic Nodule | X 3 3 | 8 2.6|
Hyperplasia, Focal, Histiocytic | 1 2 1 1 2 3 2 3 1 | 16 1.6|
Infiltration Cellular, Focal, | | |
Polymorphonuclear | | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 1 1 1 2 2 2 2 1 2 2 2 2| 35 1.9|
Mixed Cell Focus | X X X X | 7 |
Bile Duct, Hyperplasia | 2 2 2 2 3 2 2 1 1 1 2 1 1 1 2 1 2 3 3 | 34 1.7|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 2 | 1 2.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 1 2 2 2 2 | 10 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0| |
| 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Vacuolization Cytoplasmic| 1 | 2 2.0|
Hepatocyte, Periportal, | | |
Centrilobular, Vacuolization | | |
Cytoplasmic | 2 | 1 2.0|
Hepatocyte, Centrilobular, Necrosis | | 1 3.0|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | 3 3 4 | 8 3.4|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 13 |
Fat, Necrosis, Focal | 3 2 3 3 3 | 9 2.8|
Fat, Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | 2 1 1 | 9 1.6|
Duct, Cyst, Focal | 1 1| 4 1.0|
Duct, Cyst, Focal, Multiple | 1 2 1 2 | 11 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Inflammation, Chronic | 3| 1 3.0|
Perforation | | 1 3.0|
Epithelium, Hyperplasia | 2 2 3| 6 2.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
Malformation | X | 1 |
Peridontal Tissue, Inflammation, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0| |
| 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Chronic | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 1 | 5 1.0|
Angiectasis | 2 | 1 2.0|
Cytoplasmic Alteration, Focal | 2 2 2 | 3 2.0|
Fibrosis, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 2 2 1 2 | 7 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 2 3.5|
Pars Distalis, Angiectasis | 3 | 2 3.5|
Pars Distalis, Cyst | | 1 3.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 2 1.0|
Pars Distalis, Degeneration, Cystic, | | |
Focal | 3 2 3 | 11 2.4|
Pars Distalis, Hemorrhage, Focal | 2 3 1 2 2 3 | 10 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0| |
| 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pars Distalis, Hyperplasia, Focal | 3 2 3 3 3 3 | 10 2.8|
Pars Distalis, Infiltration Cellular,| | |
Focal | 2 | 1 2.0|
Rathke's Cleft, Hemorrhage | | 2 2.5|
Rathke's Cleft, Hyperplasia, Cystic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + A + + A +| 43 |
Ultimobranchial Cyst | 1 | 1 1.0|
C-Cell, Hyperplasia | 3 3 3 3 2 1 3 3 2 2 3 3 2 2 3 3 3 2 3 2 2 2| 43 2.5|
Follicle, Mineralization, Focal | 3 1 1 1 1 1 1 1 2 1 1 2 1 3 1 1 1 2 1 | 40 1.3|
Follicular Cell, Hypertrophy | 2 1 1 2 1 1 2 1 1 2 1 1 1 1 1 | 27 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + + + | 4 |
Mediastinum, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 3 | 6 2.8|
Hyperplasia, Cystic | 2 | 3 2.3|
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Ovary | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Interstitial Cell, Hyperplasia | | 1 3.0|
Periovarian Tissue, Cyst | 3 | 2 3.5|
|__________________________________________________________________________|____________|
Oviduct | | 2 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 3| 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 1 1 3 3 2 2 3| 16 1.9|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0| |
| 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Vagina | + + + | 3 |
Cyst | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Hyperplasia, Focal, Histiocytic | 4 2 | 2 3.0|
Hyperplasia | | 1 2.0|
Myeloid Cell, Hyperplasia | 3 | 2 2.5|
Myeloid Cell, Erythroid Cell, | | |
Hyperplasia | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 30 |
Mediastinal, Angiectasis | 3 | 1 3.0|
Mediastinal, Ectasia | 3 3 | 2 3.0|
Mediastinal, Hemorrhage | 3 3 | 5 3.0|
Mediastinal, Hyperplasia, Histiocytic| 3 | 2 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 2 3.0|
Mediastinal, Infiltration Cellular, | | |
Mixed Cell | 3 | 1 3.0|
Mediastinal, Pigmentation | 3 | 1 3.0|
Pancreatic, Hyperplasia, Histiocytic | 2 3 3 1 2 3 | 15 2.5|
Pancreatic, Hyperplasia, Lymphoid | | 1 1.0|
Pancreatic, Pigmentation | 3 1 | 3 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal, Histiocytic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0| |
| 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hematopoietic Cell Proliferation | 4 2 2 2 2| 8 2.4|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Focal, Histiocytic | 3 4 | 2 3.5|
Pigmentation, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 3 2 4 3 4 2 4 4 3 3 3 2 2 3 2 2 3 | 34 3.0|
Ectasia | 2 4 2| 3 2.7|
Fibrosis | 2 | 1 2.0|
Hyperplasia | 3 2 2 3 2 | 10 2.4|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 3 4 3 | 10 2.9|
Hemorrhage, Focal | 2 | 3 1.7|
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0| |
| 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 3.0|
Hemorrhage, Focal | | 1 3.0|
Hyperplasia, Histiocytic | 2 1 2 1| 5 1.6|
Infiltration Cellular, Mixed Cell | | 2 2.0|
Inflammation, Chronic, Focal | 1 1 | 4 1.5|
Metaplasia, Focal, Osseous | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 3 2.0|
Mediastinum, Edema | | 1 3.0|
Peribronchiolar, Hyperplasia, | | |
Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + A + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Cataract | 3 | 1 3.0|
Retina, Degeneration | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Histiocytic | 1 | 1 1.0|
Inflammation, Chronic, Focal | | 1 1.0|
Metaplasia, Focal, Squamous | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 3| 3| 0| 3| 3| 8| 3| 3| 3| 3| 9| 3| 3| 1| 0| |
| 4| 4| 1| 4| 4| 5| 5| 5| 6| 7| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 9| 4| 4| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Kidney | + A + + + + + + + + + + + + + + + + + + + + + A +| 47 |
Cyst | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infarct | | 1 3.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 37 1.1|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 3 2 2 2 2 | 11 2.2|
Renal Tubule, Pigmentation | 1 2 2 | 4 1.8|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + I + + A + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Epithelium, Cyst | 1 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + A + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + A + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X|
Cholangiofibrosis | 4 |
Clear Cell Focus | X X X X X X X|
Congestion | |
Degeneration, Cystic, Focal | |
Eosinophilic Focus | X |
Fibrosis, Focal | |
Hepatodiaphragmatic Nodule | 3 2 |
Hyperplasia, Focal, Histiocytic | 2 3 2 2 1 2 1 3 2 1|
Hyperplasia, Focal, Regenerative | 4 |
Hyperplasia, Regenerative | |
Infiltration Cellular, Mixed Cell | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 3 2 2 2 2 3 3 3 2 3 2 2|
Hepatocyte, Necrosis, Focal | |
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | 3 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 1 1 1 1 |
Hepatocyte, Centrilobular, Necrosis | 2 |
Hepatocyte, Centrilobular, | |
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Vacuolization Cytoplasmic | 3 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Fat, Necrosis, Focal | 3 3 2 3 2 2 3 |
|__________________________________________________________________________|
Oral Mucosa | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lipomatosis | 1 |
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 1 1 2 1 2 2 2 1 1 1 2 |
Duct, Cyst, Focal | 2 |
Duct, Cyst, Focal, Multiple | 1 2 1 2 2 1 2 1 2|
Duct, Hyperplasia, Focal | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Ulcer | 2 |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
|__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Infiltration Cellular, Mixed Cell | 1 1 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | 3 3 |
Cytoplasmic Alteration, Focal | 2 |
Degeneration, Cystic, Focal | 2 |
Hemorrhage | 2 |
Vacuolization Cytoplasmic, Focal | 2 2 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia, Focal | 1 |
Infiltration Cellular, Focal, | |
Lymphoid | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 3 3 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 3 |
Pars Distalis, Degeneration, Cystic, | |
Focal | 2 |
Pars Distalis, Hemorrhage, Focal | 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Rathke's Cleft, Hemorrhage | 3 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + A + + + + +|
Congestion | 1 |
C-Cell, Hyperplasia | 1 2 1 2 2 3 3 2 3 2 3 3 2 2 2 3 2 2 3 3 2 3|
Follicle, Mineralization, Focal | 3 2 2 3 3 2 3 2 3 3 1 1 3 3 3 2 3 2 2 2 2 1|
Follicular Cell, Hypertrophy | 2 2 3 2 2 1 2 1 2 2 2 2 2 1 1 2 2 1 1 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
Tissue NOS | + + + + |
Mediastinum, Thrombosis | 3 |
Oral, Foreign Body, Focal | |
Oral, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Hyperplasia, Cystic | |
Hyperplasia | |
Inflammation, Chronic | 1 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Corpus Luteum, Hyperplasia | 3 |
Periovarian Tissue, Cyst | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Focal, Suppurative | |
Inflammation, Suppurative | |
Ulcer, Chronic Active | |
Endometrium, Hyperplasia, Cystic | 2 2 1 2 2 1 |
|__________________________________________________________________________|
Vagina | |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Focal, Histiocytic | 4 4 |
Myeloid Cell, Hyperplasia | 3 |
Myeloid Cell, Erythroid Cell, | |
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pigmentation | |
Deep Cervical, Hyperplasia, Plasma | |
Cell | |
Mediastinal, Ectasia | 3 |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Pancreatic, Ectasia | |
Pancreatic, Hemorrhage | 2 3 2 |
Pancreatic, Hyperplasia, Histiocytic | 1 3 3 3 3 2 3 3 2 2 3 |
Pancreatic, Pigmentation | 2 1 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M + M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Histiocytic | 3 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 2 3 3 3 2 1|
Hemorrhage | 2 |
Hyperplasia, Focal, Histiocytic | 3 4 |
Infarct | |
Red Pulp, Fibrosis, Diffuse | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + I + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 3 4 4 4 3 3 4 3 2 2 4 3 4 3 3 3 2 2 2|
Ectasia | 3 |
Fibrosis | 3 3 |
Hyperplasia, Focal | 4 |
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Hyperplasia | 3 2 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 4 3 3 |
Hemorrhage, Focal | 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage, Focal | 3 3 |
Hyperplasia, Focal, Histiocytic | 3 |
Hyperplasia, Histiocytic | 1 |
Infiltration Cellular, Mixed Cell | 3 |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Interstitium, Edema | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | |
Respiratory Epithelium, Metaplasia, | |
Focal, Squamous | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3|
| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 4| 6| 0| 7| 7| 7| 7| 3| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | 3 |
Bilateral, Atrophy | |
Retina, Degeneration | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | 1 |
|__________________________________________________________________________|
Lacrimal Gland | + |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +|
Atrophy, Focal | |
Cyst | |
Inflammation, Chronic, Focal, | |
Granulomatous | |
Nephropathy | 2 1 1 2 1 1 1 1 1 1 3 1 1 1 1 1 1 1 2|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 2 |
Renal Tubule, Pigmentation | 1 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 52
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + A + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Cyst | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + A + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 42 |
Cholangiofibrosis | 4 4 | 3 4.0|
Clear Cell Focus | X X X | 10 |
Congestion | 2 | 1 2.0|
Degeneration, Cystic, Focal | 2 2 2 | 3 2.0|
Eosinophilic Focus | X | 2 |
Fibrosis, Focal | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X | 3 2.5|
Hyperplasia, Focal, Histiocytic | 1 3 1 3 3 2 1 1 2 1 1 2 2| 23 1.8|
Hyperplasia, Focal, Regenerative | | 1 4.0|
Hyperplasia, Regenerative | 4 4 | 2 4.0|
Infiltration Cellular, Mixed Cell | 2 3 2 2 2 2 3 1 2 2 2 2 2 2 2 2 2 2 2 2 1 2| 41 2.0|
Mixed Cell Focus | X X X X X | 8 |
Bile Duct, Hyperplasia | 3 2 1 3 2 1 3 1 1 1 1 3 1 1| 26 2.0|
Hepatocyte, Necrosis, Focal | 2 | 1 2.0|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 3 | 2 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 2 2 1 1 | 10 1.4|
Hepatocyte, Centrilobular, Necrosis | 3 | 2 2.5|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | 2 | 3 2.3|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 16 |
Fat, Necrosis, Focal | 2 3 2 3 3 3 | 13 2.6|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Lipomatosis | | 1 1.0|
Acinus, Atrophy, Diffuse | 4 | 1 4.0|
Acinus, Atrophy, Focal | 1 2 1 2 1| 16 1.4|
Duct, Cyst, Focal | | 1 2.0|
Duct, Cyst, Focal, Multiple | 2 2 1 1 2 2 1 2 1| 18 1.6|
Duct, Hyperplasia, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Ulcer | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Peridontal Tissue, Inflammation, | | |
Chronic, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 2 2.0|
Infiltration Cellular, Mixed Cell | | 4 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 2 1.0|
Angiectasis | | 2 3.0|
Cytoplasmic Alteration, Focal | 1 | 2 1.5|
Degeneration, Cystic, Focal | | 1 2.0|
Hemorrhage | 3| 2 2.5|
Vacuolization Cytoplasmic, Focal | 2 2 2 2 | 8 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Hyperplasia, Focal | | 1 1.0|
Infiltration Cellular, Focal, | | |
Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + M + + M + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 2 3 2 3 3 3 | 13 2.6|
Pars Distalis, Cyst | 1 | 2 1.5|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 | 3 1.7|
Pars Distalis, Degeneration, Cystic, | | |
Focal | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pars Distalis, Hemorrhage, Focal | 3 | 2 3.0|
Pars Distalis, Hyperplasia, Focal | 2 1 | 4 1.8|
Rathke's Cleft, Hemorrhage | 3 3 3 | 6 2.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + A + + + + +| 46 |
Congestion | | 1 1.0|
C-Cell, Hyperplasia | 3 3 2 2 3 1 2 3 2 3 2 3 2 3 1 1 2 2 3 2 2 3 | 44 2.3|
Follicle, Mineralization, Focal | 1 3 3 3 1 1 1 1 1 1 1 1 2 3 1 2 2 2 2 3 3 3| 44 2.1|
Follicular Cell, Hypertrophy | 2 2 2 1 1 3 1 2 2 1 2 2 1 2 1 2 2 2 2 3 3| 42 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + + | 6 |
Mediastinum, Thrombosis | | 1 3.0|
Oral, Foreign Body, Focal | 3 | 1 3.0|
Oral, Necrosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Degeneration, Cystic | | 1 3.0|
Hyperplasia, Cystic | 3 | 1 3.0|
Hyperplasia | 3 | 1 3.0|
Inflammation, Chronic | 3 | 3 2.3|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 1 | 4 1.8|
Corpus Luteum, Hyperplasia | | 1 3.0|
Periovarian Tissue, Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Focal, Suppurative | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Ulcer, Chronic Active | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3 3 1 1 2 | 11 1.8|
|__________________________________________________________________________|____________|
Vagina | + | 1 |
Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Hyperplasia, Focal, Histiocytic | | 2 4.0|
Myeloid Cell, Hyperplasia | 3 3 2 2 3 | 6 2.7|
Myeloid Cell, Erythroid Cell, | | |
Hyperplasia | 3 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +| 39 |
Pigmentation | 3 | 1 3.0|
Deep Cervical, Hyperplasia, Plasma | | |
Cell | 3 | 1 3.0|
Mediastinal, Ectasia | 3 3 3 | 4 3.0|
Mediastinal, Hemorrhage | 3 2 | 3 2.7|
Mediastinal, Hyperplasia, Histiocytic| 3 3| 3 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3 3 | 3 3.0|
Pancreatic, Ectasia | 3 | 1 3.0|
Pancreatic, Hemorrhage | 3 3 | 5 2.6|
Pancreatic, Hyperplasia, Histiocytic | 3 1 3 3 3 1 3 2 3 2 2 2 2 3 | 25 2.4|
Pancreatic, Pigmentation | 2 2 2 | 6 1.7|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + M M M M + M M M M M M M M M M + M M M M M| 5 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Histiocytic | 4 3 | 4 3.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 3 | 1 3.0|
Fibrosis, Focal | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 2 3 2 2 3 2 2 3 3| 17 2.4|
Hemorrhage | 3 | 2 2.5|
Hyperplasia, Focal, Histiocytic | 4 3 4 | 5 3.6|
Infarct | 3 | 1 3.0|
Red Pulp, Fibrosis, Diffuse | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 2 4 2 4 4 3 4 3 3 2 4 2 3 3 3 2 4| 38 3.1|
Ectasia | 2 | 2 2.5|
Fibrosis | 3 2 | 4 2.8|
Hyperplasia, Focal | | 1 4.0|
Hyperplasia | 2 2 3 2 3 2 2 | 9 2.3|
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 3 3 3 2 3 | 9 3.0|
Hemorrhage, Focal | | 2 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hemorrhage, Focal | | 2 3.0|
Hyperplasia, Focal, Histiocytic | 3 | 2 3.0|
Hyperplasia, Histiocytic | 1 | 2 1.0|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Inflammation, Chronic, Focal | 1 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 2 1.5|
Interstitium, Edema | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation | 3 | 1 3.0|
Respiratory Epithelium, Metaplasia, | | |
Focal, Squamous | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cataract | 3 | 2 3.0|
Bilateral, Atrophy | 4 | 1 4.0|
Retina, Degeneration | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 | 1 1.0|
Inflammation, Chronic, Focal | 1 | 2 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 4| 0| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 9| 9| 9| 9| 2| 3| 6| 6| 6| 6| 9| 9| 6| 9| 9| 5| 6| 6| 6| 0| 5| 8| 5| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lacrimal Gland | + | 2 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + A + + + A + + + + +| 47 |
Atrophy, Focal | 3 3 | 2 3.0|
Cyst | 2 | 1 2.0|
Inflammation, Chronic, Focal, | | |
Granulomatous | 3 | 1 3.0|
Nephropathy | 2 1 1 1 2 1 2 1 1 1 1 1 1 1 1 3 1 1 1| 38 1.3|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 2 2 | 5 2.0|
Renal Tubule, Pigmentation | 2 3 | 4 2.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|
| 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Ulcer | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Cholangiofibrosis | 4 2 |
Clear Cell Focus | X X X X X X X X X X X X X X|
Degeneration, Cystic, Focal | 2 2 1 2 1 1 1 1|
Eosinophilic Focus | X |
Hemorrhage, Focal | |
Hepatodiaphragmatic Nodule | 2 3 3 |
Hyperplasia, Focal, Histiocytic | 2 1 1|
Infarct | |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2|
Mixed Cell Focus | X X X X X X X X X |
Bile Duct, Hyperplasia | 3 3 3 3 3 3 2 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3|
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | 2 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 2 2 2 1 2 1 2 2 2 1 1 1 2|
Hepatocyte, Centrilobular, Necrosis | 4 |
Hepatocyte, Centrilobular, | |
Vacuolization Cytoplasmic | 3 |
Hepatocyte, Midzonal, Necrosis | |
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|
| 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hepatocyte, Midzonal, Vacuolization | |
Cytoplasmic | 2 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Hemorrhage | |
Fat, Necrosis, Focal | 3 2 3 3 3 2 3 3 |
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy, Focal | 1 1 3 2 3 1 2 1 2 1 1 |
Acinus, Hyperplasia, Focal | |
Duct, Cyst, Focal, Multiple | 2 1 1 2 2 2 1 1 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | |
Epithelium, Cyst | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +|
Erosion | |
Ulcer | |
|__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 |
Infiltration Cellular, Mixed Cell | 2 |
Thrombosis | |
Artery, Inflammation, Chronic, Focal | 2|
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|
| 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Endocardium, Valve, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + A + + + + +|
Accessory Adrenal Cortical Nodule | |
Cytoplasmic Alteration, Focal | 1 2 |
Vacuolization Cytoplasmic, Focal | 2 1 1 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hyperplasia, Focal | 1 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 1 2 |
Pars Distalis, Degeneration, Cystic, | |
Focal | 1|
Pars Distalis, Hemorrhage, Focal | |
Pars Distalis, Hyperplasia, Focal | 2|
Rathke's Cleft, Hemorrhage | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
C-Cell, Hyperplasia | 1 3 1 2 3 1 2 3 2 2 2 2 2 1 2 1 2 1 2 2 2 3|
Follicle, Cyst | 2 |
Follicle, Degeneration, Cystic, Focal| |
Follicle, Mineralization, Focal | 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
Follicular Cell, Hypertrophy, Focal | |
Follicular Cell, Hypertrophy | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|
| 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
|__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + A + + M + +|
Inflammation, Chronic | 2 1 2 1 2 1 2 2 3 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 1 1 2 1 1 3 2|
Mineralization, Focal | 2 |
Epithelium, Hyperplasia, Focal | 1 1 1 1 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Germinal Epithelium, Degeneration | 2 |
Interstitial Cell, Hyperplasia, Focal| 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + +|
Fibrosis | |
Hyperplasia | 3 3 1 2 1 2 1 3 1 1 3 4 2 1|
Myeloid Cell, Erythroid Cell, | |
Hyperplasia | 3 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Ectasia | 4 |
Deep Cervical, Hyperplasia, Plasma | |
Cell | 3 |
Mediastinal, Ectasia | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | 3 |
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|
| 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Mediastinal, Hyperplasia, Plasma Cell| |
Pancreatic, Angiectasis | |
Pancreatic, Ectasia | 3 2 |
Pancreatic, Hemorrhage | 3 |
Pancreatic, Hyperplasia, Histiocytic | 3 3 3 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Pancreatic, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Ectasia | |
Hyperplasia, Focal, Histiocytic | |
Hyperplasia, Histiocytic | 3 3|
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3 |
Hyperplasia, Focal, Histiocytic | |
Necrosis | |
Capsule, Accessory Spleen, Focal | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + A + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + A + + + + +|
Dilatation | 3 3 |
Inflammation, Chronic, Focal | 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis, Focal | 3 |
Epidermis, Hyperplasia, Focal | 3 |
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|
| 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 4 3 |
Hemorrhage, Focal | |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body, Focal | |
Hemorrhage, Focal | 1 2 1|
Hyperplasia, Histiocytic | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 2 3 1|
Alveolus, Hyperplasia, Focal, | |
Histiocytic | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2|
Nasolacrimal Duct, Inflammation | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 2| 2| 2| 2| 2| 2| 3| 0| 3| 3| 3| 9| 3|
| 0| 0| 0| 4| 4| 4| 4| 0| 0| 1| 1| 1| 9| 9| 9| 9| 9| 9| 1| 3| 1| 4| 4| 5| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
Epithelium, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +|
Infarct, Multiple | |
Nephropathy | 1 1 1 1 2 1 2 2 2 2 1 1 1 2 1 2 2 2 1 1 1 2 2|
Renal Tubule, Pigmentation | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________|__________________________________________________________________________
Page 67
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9| |
| 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + A + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + A + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + A + + + + + + + + +| 47 |
Ulcer | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 1 | 2 1.5|
Basophilic Focus | X X X X X X X X X X X | 27 |
Cholangiofibrosis | | 2 3.0|
Clear Cell Focus | X X X X X X X | 21 |
Degeneration, Cystic, Focal | 1 1 2 2 1 | 13 1.4|
Eosinophilic Focus | X | 2 |
Hemorrhage, Focal | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | 3 2 3 | 6 2.7|
Hyperplasia, Focal, Histiocytic | 2 3 2 | 6 1.8|
Infarct | 3 | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 36 2.0|
Mixed Cell Focus | X X X X | 13 |
Bile Duct, Hyperplasia | 3 3 3 3 3 3 2 3 3 3 3 3 2 2 3 1 3 3 2 3 3 3 3 3 3| 48 2.8|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 3 | 3 2.3|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 3 2 2 2 1 2 1 2 2 2 3 | 26 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9| |
| 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Centrilobular, Necrosis | | 1 4.0|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | 3 2 3 | 4 2.8|
Hepatocyte, Midzonal, Necrosis | 3 | 1 3.0|
Hepatocyte, Midzonal, Vacuolization | | |
Cytoplasmic | 2 3 3 3| 6 2.5|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 19 |
Hemorrhage | 4 | 1 4.0|
Fat, Necrosis, Focal | 3 3 3 2 | 12 2.8|
Fat, Necrosis | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 3 | 1 3.0|
Acinus, Atrophy, Focal | 2 1 1 2 2 1 3 2 3 3 3 1 | 23 1.8|
Acinus, Hyperplasia, Focal | 3 | 1 3.0|
Duct, Cyst, Focal, Multiple | 1 1 2 2 2 4 | 15 1.7|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Ulcer | 2 | 1 2.0|
Epithelium, Cyst | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 1 1 2 | 3 1.3|
Ulcer | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
Epithelium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9| |
| 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 | 6 1.5|
Infiltration Cellular, Mixed Cell | 1 | 2 1.5|
Thrombosis | 3 | 1 3.0|
Artery, Inflammation, Chronic, Focal | | 1 2.0|
Endocardium, Valve, Inflammation, | | |
Chronic, Focal | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 1 | 1 1.0|
Cytoplasmic Alteration, Focal | 1 | 3 1.3|
Vacuolization Cytoplasmic, Focal | 2 1 1 2 2 1| 12 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 1 2| 5 1.6|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + A + + A + + + + + + + + +| 48 |
Angiectasis | 3 1 | 2 2.0|
Pars Distalis, Cyst | 1 2 | 2 1.5|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 3 1.3|
Pars Distalis, Degeneration, Cystic, | | |
Focal | 1 | 2 1.0|
Pars Distalis, Hemorrhage, Focal | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9| |
| 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pars Distalis, Hyperplasia, Focal | 1 3 3| 4 2.3|
Rathke's Cleft, Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + A + + + + + + A + + + +| 47 |
C-Cell, Hyperplasia | 2 1 1 1 1 2 1 2 2 1 2 2 1 1 2 3 2 2 2 3 2 3 2| 45 1.8|
Follicle, Cyst | | 1 2.0|
Follicle, Degeneration, Cystic, Focal| 1 2 | 2 1.5|
Follicle, Mineralization, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1| 45 1.1|
Follicular Cell, Hypertrophy, Focal | 1 | 1 1.0|
Follicular Cell, Hypertrophy | 1 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + + | 5 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 2 1 1 2 2 2 1 2 1 2 3 1 2| 22 1.7|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 1 1 3 2 2 1 2 2 3 3 1 | 21 1.9|
Mineralization, Focal | 2 2| 3 2.0|
Epithelium, Hyperplasia, Focal | 2 1 2 2 1 1 | 11 1.3|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 3 | 4 3.0|
Germinal Epithelium, Degeneration | | 1 2.0|
Interstitial Cell, Hyperplasia, Focal| | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9| |
| 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrosis | 2 4 | 2 3.0|
Hyperplasia | 1 3 2 1 1 2 3 3 1 1 1 2 2 3 | 28 1.9|
Myeloid Cell, Erythroid Cell, | | |
Hyperplasia | | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + | 34 |
Ectasia | | 1 4.0|
Deep Cervical, Hyperplasia, Plasma | | |
Cell | | 1 3.0|
Mediastinal, Ectasia | 2 2 3 3 | 5 2.6|
Mediastinal, Hemorrhage | 3 3 3 | 3 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
Pancreatic, Angiectasis | 3 3 | 2 3.0|
Pancreatic, Ectasia | 3 | 3 2.7|
Pancreatic, Hemorrhage | 2 3 3 3 | 5 2.8|
Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 3 | 8 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M + M M M M M + M M M M M M M M M M M M| 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 3 | 1 3.0|
Hyperplasia, Focal, Histiocytic | 2 | 1 2.0|
Hyperplasia, Histiocytic | 3 | 3 3.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + A + A + + + + + + + + +| 48 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9| |
| 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Focal, Histiocytic | 3 | 1 3.0|
Necrosis | 4 | 1 4.0|
Capsule, Accessory Spleen, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + M + M + + + + + + + + + + + + + + +| 45 |
Dilatation | 2 1 3 4 3 | 7 2.7|
Inflammation, Chronic, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 3 3 | 3 3.3|
Hyperkeratosis, Focal | | 1 3.0|
Epidermis, Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 2 4 3 3 | 6 3.2|
Hemorrhage, Focal | 3 2| 2 2.5|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9| |
| 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 2 2.0|
Foreign Body, Focal | 2 | 1 2.0|
Hemorrhage, Focal | | 3 1.3|
Hyperplasia, Histiocytic | 1 1 | 2 1.0|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Inflammation, Chronic, Focal | 3 2 2 1 3| 5 2.2|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 1 1 | 8 1.9|
Alveolus, Hyperplasia, Focal, | | |
Histiocytic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Nasolacrimal Duct, Inflammation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + A + A + + + + + + + + +| 47 |
Infarct, Multiple | 4 | 1 4.0|
Nephropathy | 2 2 1 1 1 3 2 1 1 1 2 1 2 1 1 2 3 1 3 3 1 2| 45 1.6|
Renal Tubule, Pigmentation | 3 2 2 | 4 2.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 5| 4| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 1| 2| 3| 0| 3| 3| 3| 3| 0| 3| 3| 3| 9| |
| 6| 0| 1| 1| 1| 9| 5| 0| 1| 1| 1| 1| 1| 3| 6| 5| 1| 1| 1| 0| 6| 1| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|
| 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + A + + + + A + + + +|
Edema | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + A + + + + A + + + +|
Ulcer | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + + + A + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + A + + + + A + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X X X X X X X X X X X |
Cholangiofibrosis | 1 |
Clear Cell Focus | X X X X X X X|
Congestion | 3 |
Degeneration, Cystic, Focal | 1 2 2 |
Eosinophilic Focus | X X |
Fibrosis, Focal | 3 |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal, Histiocytic | 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Mixed Cell Focus | X X X X X |
Bile Duct, Hyperplasia | 3 3 3 3 2 3 3 3 3 3 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3|
Centrilobular, Congestion | |
Hepatocyte, Necrosis, Focal | 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Diffuse | 2 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 1 2 2 1 2 2 2 |
Hepatocyte, Periportal, Necrosis | |
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|
| 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hepatocyte, Periportal, | |
Vacuolization Cytoplasmic | 2 |
Hepatocyte, Centrilobular, Necrosis | 2 |
Hepatocyte, Centrilobular, | |
Vacuolization Cytoplasmic | 4 4 3 3 2 |
Hepatocyte, Midzonal, Vacuolization | |
Cytoplasmic, Focal | 3 |
Hepatocyte, Midzonal, Vacuolization | |
Cytoplasmic | |
Portal, Fibrosis | |
Portal, Hemorrhage | |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Angiectasis | |
Fat, Necrosis, Focal | 3 3 3 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +|
Acinus, Atrophy, Focal | 4 3 3 2 1 3 3 3 3 1 1 |
Acinus, Hyperplasia, Focal | |
Duct, Cyst, Focal, Multiple | 2 2 2 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | 2 |
Inflammation, Focal | |
Ulcer | 2 |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + A + + + +|
Erosion | |
Pigmentation, Focal | |
Epithelium, Hyperplasia, Focal | |
|__________________________________________________________________________|
Tongue | |
|__________________________________________________________________________|
Tooth | |
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|
| 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Peridontal Tissue, Hyperplasia, | |
Squamous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 |
Infiltration Cellular, Mixed Cell | 2 |
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + A + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 1 |
Cytoplasmic Alteration, Focal | |
Vacuolization Cytoplasmic, Diffuse | |
Vacuolization Cytoplasmic, Focal | 1 2 |
Capsule, Fibrosis, Focal | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Focal | 1 2 2 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia | 2 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 |
Hemorrhage | |
Pars Distalis, Cyst | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 1 |
Pars Distalis, Degeneration, Cystic, | |
Focal | 3 3 |
Pars Distalis, Hemorrhage, Focal | 3 |
Pars Distalis, Hyperplasia, Focal | 4 3 |
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|
| 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Rathke's Cleft, Hyperplasia, Cystic | 2|
|__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + A A + + A + A + + + +|
C-Cell, Hyperplasia | 2 1 2 3 2 3 3 2 3 2 2 1 2 2 2 2 3 1 1|
Follicle, Mineralization, Focal | 1 1 1 1 1 1 1 1 1 2 1 1 1 2 2 2 1 1 1|
Follicular Cell, Hypertrophy | 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + |
|__________________________________________________________________________|
Tissue NOS | + + + + + |
Mediastinum, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Penis | + + |
Thrombosis | 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Cyst | |
Degeneration, Cystic | |
Hyperplasia, Cystic | |
Inflammation, Chronic | 2 1 1 2 3|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + A + + + + + + + + +|
Inflammation, Chronic | 2 1 1 1 2 2 3 2 2 2 3|
Mineralization, Focal | 3 2 |
Epithelium, Hyperplasia, Focal | 1 1 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 |
Bilateral, Atrophy | 3 |
__________________________________________|__________________________________________________________________________|
Page 79
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|
| 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Interstitial Cell, Hyperplasia, Focal| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + A + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 3 1 2 1 4 3 2 2 2 1 2 2 3 1 1 3 3|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Mediastinal, Ectasia | 3 3 3 |
Mediastinal, Hemorrhage | 3 2 |
Mediastinal, Hyperplasia, Histiocytic| 3 3 3 |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | 3 |
Mediastinal, Inflammation, | |
Suppurative | |
Pancreatic, Ectasia | 3 |
Pancreatic, Hemorrhage | 3 |
Pancreatic, Hyperplasia, Histiocytic | 3 3 |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Pigmentation | 2 |
Renal, Hyperplasia, Focal, | |
Histiocytic | |
Renal, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M + M + M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 2 |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Amyloid Deposition | 3 |
Angiectasis, Focal | 3 3 |
Fibrosis, Focal | 3 3 |
Hematopoietic Cell Proliferation | 3 2 3 |
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|
| 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hemorrhage | 2 |
Hyperplasia, Focal, Histiocytic | |
Lymphoid Follicle, Atrophy | 3 |
|__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M M + + + + + + + + +|
Dilatation | 3 3 3 |
Hyperplasia | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 3 |
Fibrosis, Focal | 3 |
Inflammation, Chronic, Focal | 3 3 |
Ulcer | 3 |
Artery, Subcutaneous Tissue, | |
Thrombosis | |
Lip, Inflammation, Chronic, Focal | 3 |
Subcutaneous Tissue, Cyst | 4 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 3 2 3 |
Hemorrhage, Focal | 4 |
Cerebrum, Ventricle, Hydrocephalus | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|
| 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage, Focal | |
Hyperplasia, Focal, Histiocytic | |
Hyperplasia, Histiocytic | 1 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic, Focal | 1 1 |
Inflammation, Focal, Suppurative | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 |
Alveolar Epithelium, Metaplasia, | |
Squamous | 3 |
Interstitium, Edema | 3 |
Mediastinum, Edema | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + A + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Suppurative | 3 |
Nasolacrimal Duct, Inflammation | 3 2 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + A + + + + + + + + +|
Peritracheal Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + A + + + + + + + + +|
Cataract | 3 2|
Exudate | 3|
Retina, Degeneration | 4 3|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Focal, Histiocytic | 2 |
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 4| 2| 3| 6| 3| 2| 0| 2| 3| 3| 1| 2| 5| 6| 1| 3| 3| 2| 3| 6| 2| 2| 2| 3|
| 3| 2| 9| 8| 0| 0| 9| 3| 9| 1| 1| 9| 1| 2| 3| 4| 0| 0| 6| 1| 2| 9| 9| 9| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
125 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Inflammation, Chronic, Focal | |
|__________________________________________________________________________|
Lacrimal Gland | + |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + A + + + + + + + + + + A A + + A + + + + + +|
Cyst, Multiple | 2|
Hydronephrosis | 4 |
Infarct, Multiple | |
Metaplasia, Focal, Lipocyte | 3|
Nephropathy | 2 1 2 1 1 1 2 2 1 2 1 1 2 2 2 1 1 1 2|
Cortex, Medulla, Atrophy | 4 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Pigmentation | 1 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
Calculus Micro Observation Only | 3 |
Transitional Epithelium, Hyperplasia,| |
Diffuse | 2 |
__________________________________________|__________________________________________________________________________
Page 83
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3| |
| 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| 46 |
Edema | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| 46 |
Ulcer | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X| 30 |
Cholangiofibrosis | | 1 1.0|
Clear Cell Focus | X X X X X X X X X X X| 18 |
Congestion | 3 | 2 3.0|
Degeneration, Cystic, Focal | 1 1 2 2 2 2 | 9 1.7|
Eosinophilic Focus | X | 3 |
Fibrosis, Focal | | 1 3.0|
Hepatodiaphragmatic Nodule | 3 3 | 2 3.0|
Hyperplasia, Focal, Histiocytic | 1 | 2 1.5|
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1| 29 1.9|
Mixed Cell Focus | X X X X X X| 11 |
Bile Duct, Hyperplasia | 3 3 3 3 3 2 3 1 3 3 2 3 3 3 2 3 3 3 3 3 3 3 3 3| 49 2.9|
Centrilobular, Congestion | 3 | 1 3.0|
Hepatocyte, Necrosis, Focal | | 1 2.0|
Hepatocyte, Vacuolization | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3| |
| 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Cytoplasmic, Diffuse | 4 2 | 3 2.7|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 1 2 2 1 2 2 1| 15 1.7|
Hepatocyte, Periportal, Necrosis | 3 | 1 3.0|
Hepatocyte, Periportal, | | |
Vacuolization Cytoplasmic | | 1 2.0|
Hepatocyte, Centrilobular, Necrosis | 2 2 | 3 2.0|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | 3 3 2 3 | 9 3.0|
Hepatocyte, Midzonal, Vacuolization | | |
Cytoplasmic, Focal | | 1 3.0|
Hepatocyte, Midzonal, Vacuolization | | |
Cytoplasmic | 3 | 1 3.0|
Portal, Fibrosis | 3 | 1 3.0|
Portal, Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + | 20 |
Angiectasis | 3 | 1 3.0|
Fat, Necrosis, Focal | 3 3 2 3 2 | 10 2.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | 1 1 3 1 3 2 1 2 1 2 1 3| 23 2.1|
Acinus, Hyperplasia, Focal | 2 | 1 2.0|
Duct, Cyst, Focal, Multiple | 1 1 2 1 2 2 2 1 1| 13 1.6|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Inflammation, Chronic | 2 2 3 | 4 2.3|
Inflammation, Focal | 2 | 1 2.0|
Ulcer | 2 3 2 3 | 5 2.4|
Epithelium, Hyperplasia | 2 3 2 3 2 2 3 | 8 2.4|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3| |
| 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Erosion | 2 2 | 2 2.0|
Pigmentation, Focal | 2 | 1 2.0|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Peridontal Tissue, Hyperplasia, | | |
Squamous | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 3 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 1 1 1 | 7 1.0|
Cytoplasmic Alteration, Focal | 2 1 2 | 3 1.7|
Vacuolization Cytoplasmic, Diffuse | 3 | 1 3.0|
Vacuolization Cytoplasmic, Focal | 2 2 1 1 1 1 | 8 1.4|
Capsule, Fibrosis, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 1 2 1 1 1 1 2 | 12 1.4|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3| |
| 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 4 2.5|
Hemorrhage | 4 | 1 4.0|
Pars Distalis, Cyst | 3 | 1 3.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 1 1 2 2| 7 1.4|
Pars Distalis, Degeneration, Cystic, | | |
Focal | | 2 3.0|
Pars Distalis, Hemorrhage, Focal | 2 | 2 2.5|
Pars Distalis, Hyperplasia, Focal | | 2 3.5|
Rathke's Cleft, Hyperplasia, Cystic | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 44 |
C-Cell, Hyperplasia | 2 2 2 1 2 1 2 2 2 2 1 3 1 1 2 2 2 2 2 3 2 2 2| 42 2.0|
Follicle, Mineralization, Focal | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1| 43 1.1|
Follicular Cell, Hypertrophy | 3 1 1 1 1 1 1 | 13 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 1 |
|__________________________________________________________________________|____________|
Tissue NOS | + | 6 |
Mediastinum, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Penis | | 2 |
Thrombosis | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3| |
| 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
Degeneration, Cystic | 3 3 | 2 3.0|
Hyperplasia, Cystic | 3 | 1 3.0|
Inflammation, Chronic | 2 2 1 3 2 2 1 | 12 1.8|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 1 3 1 2 3 2 1 3 2 3 2 3 | 23 2.0|
Mineralization, Focal | | 2 2.5|
Epithelium, Hyperplasia, Focal | 2 | 4 1.3|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 2 3 3 3 | 10 2.9|
Bilateral, Atrophy | | 1 3.0|
Interstitial Cell, Hyperplasia, Focal| 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | 2 1 2 3 2 2 3 3 3 2 3 4 3 3 2 1 2 3| 35 2.3|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 24 |
Mediastinal, Ectasia | 3 3 3 3 | 7 3.0|
Mediastinal, Hemorrhage | | 2 2.5|
Mediastinal, Hyperplasia, Histiocytic| | 3 3.0|
Mediastinal, Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Mediastinal, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Pancreatic, Ectasia | 3 3 | 3 3.0|
Pancreatic, Hemorrhage | 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3| |
| 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Pancreatic, Hyperplasia, Histiocytic | 3 3 3 | 5 3.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Pancreatic, Pigmentation | | 1 2.0|
Renal, Hyperplasia, Focal, | | |
Histiocytic | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 1 3.0|
Hemorrhage | 3 | 2 2.5|
Hyperplasia, Histiocytic | 3 3 | 3 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | | 1 3.0|
Angiectasis, Focal | | 2 3.0|
Fibrosis, Focal | | 2 3.0|
Hematopoietic Cell Proliferation | 2 2 2 | 6 2.3|
Hemorrhage | | 1 2.0|
Hyperplasia, Focal, Histiocytic | 2 | 1 2.0|
Lymphoid Follicle, Atrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + I +| 48 |
Cyst | 2 | 1 2.0|
Hemorrhage | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + M + M + + M + + + A + + + + + + + +| 43 |
Dilatation | 2 3 3 2 | 7 2.7|
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3| |
| 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 3.0|
Fibrosis, Focal | 3 | 2 3.0|
Inflammation, Chronic, Focal | | 2 3.0|
Ulcer | | 1 3.0|
Artery, Subcutaneous Tissue, | | |
Thrombosis | 3 | 1 3.0|
Lip, Inflammation, Chronic, Focal | | 1 3.0|
Subcutaneous Tissue, Cyst | | 1 4.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Hyperostosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 3 | 6 2.8|
Hemorrhage, Focal | 3 | 2 3.5|
Cerebrum, Ventricle, Hydrocephalus | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hemorrhage, Focal | 2 | 1 2.0|
Hyperplasia, Focal, Histiocytic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3| |
| 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Hyperplasia, Histiocytic | | 1 1.0|
Infiltration Cellular, Mixed Cell | 2 2 | 3 2.0|
Inflammation, Chronic, Focal | | 2 1.0|
Inflammation, Focal, Suppurative | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 1 3 | 5 1.6|
Alveolar Epithelium, Metaplasia, | | |
Squamous | | 1 3.0|
Interstitium, Edema | | 1 3.0|
Mediastinum, Edema | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Nasolacrimal Duct, Inflammation | | 3 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Peritracheal Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Cataract | | 2 2.5|
Exudate | | 1 3.0|
Retina, Degeneration | | 2 3.5|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal, Histiocytic | | 1 2.0|
Inflammation, Chronic, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 3| 7| 3| 6| 2| 2| 0| 9| 5| 3| 2| 1| 1| 2| 7| 8| 2| 1| 2| 3| 3| 3| 9| 3| |
| 0| 0| 4| 1| 8| 9| 9| 5| 9| 5| 1| 9| 4| 4| 9| 2| 2| 9| 4| 9| 0| 0| 0| 5| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
125 MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Cyst, Multiple | | 1 2.0|
Hydronephrosis | | 1 4.0|
Infarct, Multiple | 3 | 1 3.0|
Metaplasia, Focal, Lipocyte | | 1 3.0|
Nephropathy | 2 2 1 1 1 1 2 1 2 2 3 1 3 2 1 3 1 2 2 2 2 2 2 2 2| 44 1.7|
Cortex, Medulla, Atrophy | | 1 4.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 2.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 | 1 2.0|
Renal Tubule, Hyperplasia, Focal | 2 | 1 2.0|
Renal Tubule, Pigmentation | 2 2 | 4 1.8|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Calculus Micro Observation Only | | 1 3.0|
Transitional Epithelium, Hyperplasia,| | |
Diffuse | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|
| 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + A + + + + + A|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + A|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A A + + + + + + + + + + A + + + + + A|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + A A + + + A + + + + + + A + + + + + A|
Epithelium, Necrosis | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A A + + + A + + + + + + A + + + + + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + A|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X X X X X X X X X |
Cholangiofibrosis | |
Clear Cell Focus | X X X X X X X X X X X X X |
Degeneration, Cystic, Focal | 2 2 2 1 2 4 |
Hepatodiaphragmatic Nodule | 3 |
Hyperplasia, Focal, Histiocytic | 1 1 1 |
Hyperplasia, Focal, Lymphoid | |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2 |
Mixed Cell Focus | X X |
Bile Duct, Hyperplasia | 3 3 3 3 3 3 3 2 3 3 2 2 3 3 3 3 3 1 3 2 4 2 1 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 2 2 2 2 |
Hepatocyte, Periportal, | |
Vacuolization Cytoplasmic | 2 |
Hepatocyte, Centrilobular, Necrosis | 3 2 3 |
Hepatocyte, Centrilobular, | |
Vacuolization Cytoplasmic | 3 3 3 3 3 4 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + +|
Hemorrhage | 3 |
__________________________________________|__________________________________________________________________________|
Page 93
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|
| 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation, Chronic | 3 |
Fat, Necrosis, Focal | 1 3 2 3 2 3 3 3|
Fat, Necrosis | 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 2 3 3 2 1 3 2 1 1 3 1 1 3 2 3 2|
Duct, Cyst, Focal | 3 |
Duct, Cyst, Focal, Multiple | 2 2 3 2 1 2 2 1 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic, Focal | |
Inflammation, Focal | 3 |
Ulcer | 2 1 |
Epithelium, Hyperplasia, Focal | 3 |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Erosion | 2 1 2 |
Pigmentation, Focal | 1 |
|__________________________________________________________________________|
Tongue | |
|__________________________________________________________________________|
Tooth | |
Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 94
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|
| 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 2 1 |
Atrophy | 3 |
Cytoplasmic Alteration, Focal | 2 |
Degeneration, Cystic, Focal | |
Hyperplasia, Diffuse | 3 |
Necrosis, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 2 3 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 |
Pars Distalis, Hemorrhage, Focal | |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Pars Nervosa, | |
Hemorrhage, Focal | |
Pars Intermedia, Hemorrhage, Focal | |
Rathke's Cleft, Hemorrhage | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + A A + + + A + + + + + + A + + + + + A|
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia | 2 3 3 2 2 2 2 3 2 2 1 2 3 3 1 3 2 1 |
Follicle, Cyst | |
Follicle, Mineralization, Focal | 3 1 3 2 1 1 3 1 2 3 2 1 2 2 1 1 1 1 3 2 |
Follicular Cell, Hypertrophy | 1 1 2 2 2 1 2 1 1 1 2 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
__________________________________________|__________________________________________________________________________|
Page 95
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|
| 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
|__________________________________________________________________________|
Tissue NOS | + + |
Abdominal, Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Degeneration, Cystic | |
Inflammation, Chronic | 2 2 2 2 1 1 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 4 3 2 4 1 3 1 2 3 4 2 |
Mineralization, Focal | 2 |
Epithelium, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 3 3 3 3 |
Interstitial Cell, Hyperplasia, Focal| 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 4 3 2 2 2 3 2 3 2 3 2 3 3 3 3|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Deep Cervical, Hemorrhage | 3 |
Mediastinal, Angiectasis | 3|
Mediastinal, Ectasia | 4 3 2 |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Histiocytic| 3|
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 3 |
Pancreatic, Ectasia | 3 3 |
__________________________________________|__________________________________________________________________________|
Page 96
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|
| 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 |
Pancreatic, Pigmentation | 3 |
Renal, Hemorrhage | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + M M M M M + M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 3 3 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A|
Angiectasis, Focal | 3 |
Fibrosis, Focal | 3 3 |
Hematopoietic Cell Proliferation | 2 2 3 3 |
Hyperplasia, Focal, Histiocytic | 1 |
Metaplasia, Focal, Lipocyte | |
Pigmentation, Focal | 3 |
|__________________________________________________________________________|
Thymus | + I + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hemorrhage | 2 2 3 |
Hyperplasia, Lymphoid | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + M + + + + + + + +|
Dilatation | 2 3 2 2 |
Hyperplasia | 3 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 2 |
Hyperkeratosis, Focal | 3 |
Subcutaneous Tissue, Cyst Epithelial | |
Inclusion | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal, Suppurative | 3 |
__________________________________________|__________________________________________________________________________|
Page 97
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|
| 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 3 3 3 3|
Hemorrhage, Focal | 1 2 |
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3|
Hemorrhage, Focal | 2 |
Hemorrhage | |
Hyperplasia, Focal, Histiocytic | |
Hyperplasia, Histiocytic | |
Infiltration Cellular, Mixed Cell | 2|
Inflammation, Chronic, Focal | 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Edema, Focal | 2 |
Mediastinum, Edema | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + A|
Foreign Body | 2 |
Inflammation, Suppurative | 2 3 2 1 |
Olfactory Epithelium, Hyperplasia, | |
Focal | 2 |
Respiratory Epithelium, Hyperplasia, | |
Focal | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 98
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 2| 5| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 6| 1| 4| 3| 0| 6| 9| 3| 3| 3| 6| 3| 3| 6| 0| 9| 3| 7| 3| 3| 2| 2| 2| 0|
| 1| 0| 4| 7| 1| 9| 1| 8| 1| 1| 1| 6| 0| 0| 7| 3| 5| 1| 3| 1| 1| 9| 9| 9| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + A + + + + + + + + + + + + A|
Cataract | 3 |
Cornea, Inflammation, Chronic | 3 |
Retina, Degeneration | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Histiocytic | |
Inflammation, Chronic, Focal | |
|__________________________________________________________________________|
Lacrimal Gland | + |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Nephropathy | 1 1 3 1 2 1 1 2 2 2 1 1 3 2 2 1 3 1 3 2 2 2 2 1 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 3 1 |
Renal Tubule, Pigmentation | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hemorrhage | 2 2 |
Inflammation, Chronic | 4 |
__________________________________________|__________________________________________________________________________
Page 99
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3| |
| 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + A + + A + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + A + + A + +| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + A + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + A + +| 42 |
Epithelium, Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + A + + A + +| 42 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 33 |
Cholangiofibrosis | 4 | 1 4.0|
Clear Cell Focus | X X X X X X X X X X X X X X X X| 29 |
Degeneration, Cystic, Focal | 2 2 2 2 1 2| 12 2.0|
Hepatodiaphragmatic Nodule | 3 3 | 3 3.0|
Hyperplasia, Focal, Histiocytic | 1 2 2 1 3 | 8 1.5|
Hyperplasia, Focal, Lymphoid | 3 | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 1 2 1 2 3 2 2 2 2 1 2 2 2 2 2 | 33 1.9|
Mixed Cell Focus | X | 3 |
Bile Duct, Hyperplasia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 46 2.8|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 2 2 2 1 2 3 2 1 2 | 14 1.9|
Hepatocyte, Periportal, | | |
Vacuolization Cytoplasmic | | 1 2.0|
Hepatocyte, Centrilobular, Necrosis | 2 3 2 | 6 2.5|
Hepatocyte, Centrilobular, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3| |
| 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Vacuolization Cytoplasmic | 2 3 3 2 3 3 | 12 2.9|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 19 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Fat, Necrosis, Focal | 3 3 2 3 2 | 13 2.5|
Fat, Necrosis | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Acinus, Atrophy, Focal | 1 1 1 2 2 3 2 1 1 2 | 27 1.9|
Duct, Cyst, Focal | | 1 3.0|
Duct, Cyst, Focal, Multiple | 1 2 2 2 1 2 2 2 2 | 18 1.8|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 3 | 1 3.0|
Inflammation, Chronic, Focal | 3 | 1 3.0|
Inflammation, Focal | | 1 3.0|
Ulcer | | 2 1.5|
Epithelium, Hyperplasia, Focal | | 1 3.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Erosion | 2 | 4 1.8|
Pigmentation, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Malformation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3| |
| 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Blood Vessel | | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 1 2 2 | 7 1.7|
Thrombosis | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 4 1.3|
Atrophy | | 1 3.0|
Cytoplasmic Alteration, Focal | 1 | 2 1.5|
Degeneration, Cystic, Focal | 4 2 | 2 3.0|
Hyperplasia, Diffuse | | 1 3.0|
Necrosis, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 1 1 2| 7 1.9|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 1 2 1 2 | 9 1.6|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + + + + + M + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Angiectasis | | 1 2.0|
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 1 | 3 1.0|
Pars Distalis, Hemorrhage, Focal | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 1 4 2 | 3 2.3|
Pars Distalis, Pars Nervosa, | | |
Hemorrhage, Focal | 3 | 1 3.0|
Pars Intermedia, Hemorrhage, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3| |
| 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Rathke's Cleft, Hemorrhage | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + A + +| 43 |
C-Cell, Hyperplasia, Focal | 2 | 1 2.0|
C-Cell, Hyperplasia | 3 1 2 2 2 2 2 1 2 1 1 2 3 3 1 2 2 1 2 3 2 3 2| 41 2.0|
Follicle, Cyst | 2| 1 2.0|
Follicle, Mineralization, Focal | 3 3 3 1 1 1 3 1 2 1 3 3 3 1 3 3 3 3 2 1 1 1| 42 2.0|
Follicular Cell, Hypertrophy | 1 2 2 1 1 1 2 2 2 2 1 1 2 2 1 2 2 | 33 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 1 |
|__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Abdominal, Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Degeneration, Cystic | 3 | 1 3.0|
Inflammation, Chronic | 1 2 2 2 2 1 2 1 3 2 | 18 1.8|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 2 2 2 1 2 2 2 1 1 2 2 2 2 2 3| 29 2.2|
Mineralization, Focal | 2 2 | 3 2.0|
Epithelium, Hyperplasia, Focal | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 | 9 2.9|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3| |
| 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Interstitial Cell, Hyperplasia, Focal| | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 3 3 2 3 3 3 2 1 1 2 1 2 1 2 2 2 2 3 3 2| 41 2.4|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 26 |
Deep Cervical, Hemorrhage | | 1 3.0|
Mediastinal, Angiectasis | | 1 3.0|
Mediastinal, Ectasia | 3 3 | 5 3.0|
Mediastinal, Hemorrhage | 3 | 2 3.0|
Mediastinal, Hyperplasia, Histiocytic| 3 | 2 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 2 3.0|
Pancreatic, Ectasia | 3 | 3 3.0|
Pancreatic, Hemorrhage | | 1 2.0|
Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 3 | 9 3.0|
Pancreatic, Pigmentation | | 1 3.0|
Renal, Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M + M M M M M M M M M M M M M M| 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + I + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | | 1 3.0|
Hemorrhage | | 3 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis, Focal | | 1 3.0|
Fibrosis, Focal | | 2 3.0|
Hematopoietic Cell Proliferation | | 4 2.5|
Hyperplasia, Focal, Histiocytic | 3 | 2 2.0|
Metaplasia, Focal, Lipocyte | 2 | 1 2.0|
Pigmentation, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3| |
| 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
Hemorrhage | | 3 2.3|
Hyperplasia, Lymphoid | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Dilatation | 2 2 2| 7 2.1|
Hyperplasia | | 2 2.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 3 2 | 3 2.3|
Hyperkeratosis, Focal | | 1 3.0|
Subcutaneous Tissue, Cyst Epithelial | | |
Inclusion | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 3| 7 3.0|
Hemorrhage, Focal | 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 4 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3| |
| 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Spinal Cord | + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 3 3.0|
Hemorrhage, Focal | 2 | 2 2.0|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Focal, Histiocytic | 1 | 1 1.0|
Hyperplasia, Histiocytic | 1 | 1 1.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Chronic, Focal | 1 | 3 1.3|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 | 3 2.0|
Alveolus, Edema, Focal | | 1 2.0|
Mediastinum, Edema | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 2 | 2 2.0|
Inflammation, Suppurative | 2 2 | 6 2.0|
Olfactory Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Respiratory Epithelium, Hyperplasia, | | |
Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + M + + A + +| 46 |
Cataract | | 1 3.0|
Cornea, Inflammation, Chronic | | 1 3.0|
Retina, Degeneration | | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 2| 2| 0| 3| 3| 3| 7| 3| 7| 3| 3| 3| 3| 3| 3| 2| 0| 7| 3| 3| 2| 3| 3| |
| 1| 1| 9| 9| 3| 0| 0| 0| 5| 0| 6| 1| 1| 1| 0| 0| 0| 9| 5| 5| 1| 1| 6| 0| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1000MG/L | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Harderian Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Hyperplasia, Focal, Histiocytic | 2 | 1 2.0|
Inflammation, Chronic, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Cyst | 2 | 1 2.0|
Infarct | 3 | 1 3.0|
Nephropathy | 2 2 2 2 2 2 2 1 2 1 1 2 2 1 1 2 1 1 3 2 2 2 2| 48 1.8|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 2.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 4 2.3|
Renal Tubule, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + A + +| 47 |
Hemorrhage | | 2 2.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|
| 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
Edema | 3 3 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 3 |
Hemorrhage | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + A + + + A + + + +|
Edema | 3 |
Ulcer | 4 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + A + + + + + + + + + + + + + + + + A +|
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + A + + + + + + + + + A + + + A + + A +|
|__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2|
Basophilic Focus | X X X X X X X X X X X|
Cholangiofibrosis | |
Clear Cell Focus | X X X X X X X|
Degeneration, Cystic, Focal | 2 2 2 2 2|
Eosinophilic Focus | |
Fibrosis, Focal | |
Hepatodiaphragmatic Nodule | 3 X |
Hyperplasia, Focal, Histiocytic | 2 2 |
Hyperplasia, Focal, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 3 2 2 2 2 2 2|
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 3 3 3 4 2 3 3 3 2 3 3 3 3 3 2 2 3 3 2 3 3 3 3 4 3|
Hepatocyte, Necrosis, Focal | 3 |
Hepatocyte, Vacuolization | |
__________________________________________|__________________________________________________________________________|
Page 108
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|
| 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Cytoplasmic, Diffuse | 3 4 |
Hepatocyte, Vacuolization | |
Cytoplasmic, Focal | 3 1 1 1 1 |
Hepatocyte, Centrilobular, Atrophy | 3 |
Hepatocyte, Centrilobular, Necrosis | 2 3 3 |
Hepatocyte, Centrilobular, | |
Vacuolization Cytoplasmic | 3 2 3 3 3 3 3 |
Hepatocyte, Midzonal, Vacuolization | |
Cytoplasmic | 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 3 |
Fat, Necrosis, Focal | 3 1 4 2 3 2 1 2 |
Fat, Necrosis | 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 1 3 1 1 2 1 2 3 1|
Duct, Cyst, Focal | 3 |
Duct, Cyst, Focal, Multiple | 2 2 2 2 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia, Focal, Histiocytic | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 |
Inflammation, Chronic | |
Ulcer | 2 3 |
Epithelium, Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 2 1 |
Perforation | 3 |
Ulcer | 2 2 4 |
|__________________________________________________________________________|
Tongue | +|
__________________________________________|__________________________________________________________________________|
Page 109
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|
| 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic, Focal | 3 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Cytoplasmic Alteration, Focal | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Vacuolization Cytoplasmic, Focal | 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 2 2 1 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Hemorrhage, Focal | 2 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 2 1 1 |
Pars Distalis, Hemorrhage, Focal | 3 2 |
Pars Distalis, Hyperplasia, Focal | |
Rathke's Cleft, Cyst | |
Rathke's Cleft, Hemorrhage | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + A + + + + + + + + + A + + + + + + A +|
C-Cell, Hyperplasia | 1 1 2 3 2 2 3 2 2 3 2 1 1 2 2 2 1 2 2 2 2|
Follicle, Cyst | |
Follicle, Mineralization, Focal | 3 1 3 1 1 1 3 1 3 2 2 1 3 3 3 1 3 3 2|
__________________________________________|__________________________________________________________________________|
Page 110
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|
| 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Follicular Cell, Hypertrophy | 3 2 1 1 1 2 2 2 2 3 2 3 2 1 1 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Degeneration, Cystic | |
Hyperplasia, Cystic | 3 |
Inflammation, Chronic | 2 1 1 2 1 |
Necrosis | 3 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 1 3 2 2 3 2 1 1 2 2 1|
Mineralization, Focal | 3 2 |
Epithelium, Hyperplasia, Focal | 2 1 1 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 4 |
Germinal Epithelium, Atrophy | 3 |
Interstitial Cell, Hyperplasia, Focal| 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 2 4 3 3 2 4 3 2 3 3 3 2 3 2 3 3 4 2 4 2|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 111
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|
| 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hemorrhage | 3 |
Mediastinal, Ectasia | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Hyperplasia, Lymphoid | 3|
Mediastinal, Inflammation, Chronic | |
Active | 3 |
Pancreatic, Ectasia | 3 3 3 |
Pancreatic, Hemorrhage | 3 |
Pancreatic, Hyperplasia, Histiocytic | 3 3 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M + M + M M M M M M M M + M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Ectasia | 4 4 |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 |
Atrophy | 2 |
Congestion | 3 |
Fibrosis, Focal | 4 2 2 |
Hematopoietic Cell Proliferation | 2 3 3 3 |
Hyperplasia, Focal, Histiocytic | 3 |
Infarct, Multiple | 3 |
Pigmentation | 3 |
Capsule, Fibrosis, Focal | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + M + + + M + + + + + + + + + + + + M + + + +|
Cyst | |
Dilatation | 3 |
__________________________________________|__________________________________________________________________________|
Page 112
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|
| 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Hyperplasia | |
Inflammation, Chronic, Focal | 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 2 |
Subcutaneous Tissue, Hyperplasia, | |
Focal, Histiocytic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 3 3 |
Hemorrhage, Focal | 3 2 3 |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Hyperplasia, Histiocytic | 1 |
Infiltration Cellular, Mixed Cell | 3 2|
Inflammation, Chronic, Focal | 3 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Interstitium, Edema | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2|
Inflammation, Suppurative | 2|
Nasolacrimal Duct, Inflammation | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 113
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 6| 7| 7| 7| 6| 7| 5| 7| 5| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 0| 0| 3| 4| 3| 3| 8| 9| 5| 2| 5| 2| 2| 2| 8| 3| 6| 3| 9| 3| 7| 2| 7| 2| 3|
| 1| 3| 1| 4| 9| 1| 2| 9| 1| 9| 1| 9| 9| 9| 1| 1| 2| 1| 0| 0| 8| 9| 1| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2000MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3|
Cataract | |
Cornea, Retrobulbar, Inflammation, | |
Chronic Active | 3 |
Retina, Degeneration | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Hyperplasia, Focal, Histiocytic | |
Inflammation, Chronic, Focal | |
Inflammation, Chronic Active, Diffuse| 4 |
|__________________________________________________________________________|
Lacrimal Gland | + |
|__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 3 1 2 2 2 1 1 2 2 2 4 3 1 2 1 1 1 2 3 2|
Pelvis, Infiltration Cellular, Mixed | |
Cell | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 2 |
Renal Tubule, Pigmentation | 4 3 2 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 |
Serosa, Inflammation, Focal | |
__________________________________________|__________________________________________________________________________
Page 114
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3| |
| 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | | 2 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Edema | | 1 3.0|
Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Edema | | 1 3.0|
Ulcer | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 2 2 | 3 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X| 29 |
Cholangiofibrosis | 2 | 1 2.0|
Clear Cell Focus | X X X X X X X X | 15 |
Degeneration, Cystic, Focal | 2 1 2 2 2 2 1 2 2| 14 1.9|
Eosinophilic Focus | X X | 2 |
Fibrosis, Focal | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | 3 3 3 | 5 3.0|
Hyperplasia, Focal, Histiocytic | 1 1 1 | 5 1.4|
Hyperplasia, Focal, Lymphoid | | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 | 28 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3| |
| 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mixed Cell Focus | X X X X X | 8 |
Bile Duct, Hyperplasia | 2 3 3 3 3 3 3 3 2 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 50 2.9|
Hepatocyte, Necrosis, Focal | 2 | 2 2.5|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Diffuse | 3 3 | 4 3.3|
Hepatocyte, Vacuolization | | |
Cytoplasmic, Focal | 2 1 2 2 2 1 2 2 1 1 3 2 2 | 18 1.7|
Hepatocyte, Centrilobular, Atrophy | | 1 3.0|
Hepatocyte, Centrilobular, Necrosis | 2 | 4 2.5|
Hepatocyte, Centrilobular, | | |
Vacuolization Cytoplasmic | 3 2 2 2 | 11 2.6|
Hepatocyte, Midzonal, Vacuolization | | |
Cytoplasmic | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + | 23 |
Inflammation, Chronic, Focal | | 1 3.0|
Fat, Necrosis, Focal | 3 3 1 4 3 3 | 14 2.5|
Fat, Necrosis | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Diffuse | 4 | 1 4.0|
Acinus, Atrophy, Focal | 1 2 2 2 1 2 | 15 1.7|
Duct, Cyst, Focal | | 1 3.0|
Duct, Cyst, Focal, Multiple | 2 1 2 3 1 2 1 2 2 1 | 15 1.8|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hyperplasia, Focal, Histiocytic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 3 | 4 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Ulcer | 3 3 | 4 2.8|
Epithelium, Hyperplasia | 3 2 3 2 | 7 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3| |
| 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 4 1.5|
Perforation | | 1 3.0|
Ulcer | | 3 2.7|
|__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 2 2| 10 1.8|
Infiltration Cellular, Mixed Cell | 2 2 | 2 2.0|
Inflammation, Chronic, Focal | | 1 3.0|
Thrombosis | 3 3| 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 1| 3 1.0|
Cytoplasmic Alteration, Focal | 2 2 1 | 4 1.8|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 1 2| 6 1.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 1 1 2 1 2| 13 1.8|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 3 2.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3| |
| 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hemorrhage, Focal | | 1 2.0|
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 2 1 2 | 8 1.4|
Pars Distalis, Hemorrhage, Focal | 3 | 3 2.7|
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
Rathke's Cleft, Cyst | 4 | 1 4.0|
Rathke's Cleft, Hemorrhage | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
C-Cell, Hyperplasia | 3 2 2 2 3 1 2 2 2 1 2 2 1 1 3 1 1 2 1 2 2 2 1 | 44 1.8|
Follicle, Cyst | 3 3 | 2 3.0|
Follicle, Mineralization, Focal | 2 3 3 3 3 3 3 1 1 1 3 3 3 3 1 3 3 3 3 3 2 2 2| 42 2.3|
Follicular Cell, Hypertrophy | 3 2 2 2 2 3 3 2 1 1 1 3 2 3 3 2 2 3 2 2 2 1| 40 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + + | 7 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Inflammation, Chronic | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Degeneration, Cystic | 3 3 | 2 3.0|
Hyperplasia, Cystic | | 1 3.0|
Inflammation, Chronic | 1 1 1 1 1 2 1 1 2 1 2 1 1 1 2 | 20 1.3|
Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 1 2 1 1 2 1 1 2 2 2 1 3 1 2 2 | 30 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3| |
| 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Mineralization, Focal | 2 2 | 4 2.3|
Epithelium, Hyperplasia, Focal | 1 1 1 1 1 2 1| 11 1.2|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3| 6 3.2|
Germinal Epithelium, Atrophy | | 1 3.0|
Interstitial Cell, Hyperplasia, Focal| | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Hyperplasia | 2 2 2 1 3 2 3 4 4 2 3 3 3 2 2 2 2 2 3 2 | 40 2.7|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 34 |
Hemorrhage | | 1 3.0|
Mediastinal, Ectasia | 4 3 | 3 3.3|
Mediastinal, Hemorrhage | 3 | 1 3.0|
Mediastinal, Hyperplasia, Histiocytic| | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 4 3 | 3 3.3|
Mediastinal, Inflammation, Chronic | | |
Active | | 1 3.0|
Pancreatic, Ectasia | 3 2 3 | 6 2.8|
Pancreatic, Hemorrhage | | 1 3.0|
Pancreatic, Hyperplasia, Histiocytic | 3 3 3 | 6 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M + M M M| 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | | 1 4.0|
Ectasia | 3 | 3 3.7|
Hyperplasia, Histiocytic | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 119
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3| |
| 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 3 | 3 2.3|
Atrophy | | 1 2.0|
Congestion | | 1 3.0|
Fibrosis, Focal | 3 | 4 2.8|
Hematopoietic Cell Proliferation | 2 2 3 2 2 3 2| 11 2.5|
Hyperplasia, Focal, Histiocytic | | 1 3.0|
Infarct, Multiple | | 1 3.0|
Pigmentation | | 1 3.0|
Capsule, Fibrosis, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + I + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + M + + + + + + + + + + + + + M| 44 |
Cyst | 3 | 1 3.0|
Dilatation | 2 | 2 2.5|
Hyperplasia | 3 3 | 2 3.0|
Inflammation, Chronic, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 2.0|
Subcutaneous Tissue, Hyperplasia, | | |
Focal, Histiocytic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 120
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3| |
| 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 4 2 3 | 6 3.0|
Hemorrhage, Focal | 3 3 2 | 6 2.7|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 2 | 2 2.0|
Hyperplasia, Histiocytic | 1 | 2 1.0|
Infiltration Cellular, Mixed Cell | | 2 2.5|
Inflammation, Chronic, Focal | 1 | 3 1.7|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 4 2 | 4 2.8|
Interstitium, Edema | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Nasolacrimal Duct, Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 2 3.0|
Cataract | 2 3 | 2 2.5|
Cornea, Retrobulbar, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 121
NTP Experiment-Test: 96010-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:28:43
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| |
DAY ON TEST | 0| 3| 1| 3| 3| 2| 2| 2| 6| 1| 9| 4| 3| 3| 2| 2| 4| 3| 3| 3| 2| 2| 2| 7| 3| |
| 3| 1| 8| 0| 0| 9| 9| 9| 5| 0| 9| 5| 0| 0| 9| 9| 3| 1| 1| 1| 9| 9| 9| 2| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2000MG/L | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Retina, Degeneration | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 1 2.0|
Hyperplasia, Focal, Histiocytic | 1 | 1 1.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Inflammation, Chronic Active, Diffuse| | 1 4.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Nephropathy | 2 2 2 1 1 2 2 1 2 2 2 1 2 2 1 1 2 2 1 2 2 1 2 1| 47 1.7|
Pelvis, Infiltration Cellular, Mixed | | |
Cell | 2 | 1 2.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 2 2.5|
Renal Tubule, Pigmentation | | 4 2.8|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 2 3.0|
Serosa, Inflammation, Focal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 122
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