TDMS Study 96010-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) DATE: 05/27/03
EXPERIMENT: 96010 TEST: 03 TIME: 13:32:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: 96010A
PATHOLOGIST: FARNELL, DANIEL R. CAS: 7775-09-9
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1/RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) DATE: 05/27/03
EXPERIMENT: 96010 TEST: 03 TIME: 13:32:44
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: 96010A
PATHOLOGIST: FARNELL, DANIEL R. CAS: 7775-09-9
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 1 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 381 469 503 511 545 574 630 636 636 695 |
| 699 705 706 |
| CENSORED DEATHS |
| 423 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 542 555 562 574 582 605 614 619 638 652 |
| 660 663 668 672 693 695 699 703 714 714 |
| 714 721 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 209 475 561 566 576 605 607 626 647 660 |
| 667 673 675 695 698 703 703 714 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2000MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 443 465 482 545 562 590 639 644 651 651 |
| 671 672 678 681 699 699 701 703 703 710 |
| 718 720 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 100.0 100.0 100.0 98.0 96.0 89.8 87.8 81.7 73.5 |
| | |
| | |
|125 MG/L | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 88.0 76.0 54.0 |
| | |
| | |
|1000MG/L | 100.0 100.0 98.0 98.0 98.0 96.0 96.0 88.0 80.0 62.0 |
| | |
| | |
|2000MG/L | 100.0 100.0 100.0 100.0 100.0 94.0 92.0 88.0 80.0 56.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 125 MG/L 1000MG/L 2000MG/L |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 73.5% 54.0% 62.0% 56.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.412 P=0.108 P=0.353 P=0.146 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 591.5 651.5 620.1 637.6 |
|NATURAL DEATHS (C) | (28.8) (12.3) (27.2) (18.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 687.1 693.4 687.6 688.8 |
|(STANDARD ERROR) | (12.5) ( 7.9) (12.7) (10.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 423 462 511 555 566 594 595 623 644 661 |
| 717 718 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 14 CENSORED DEATHS 0 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 365 423 433 511 541 563 623 626 636 639 |
| 644 657 714 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 401 511 514 547 573 587 587 615 615 626 |
| 636 636 651 699 699 703 703 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2000MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 475 542 635 636 644 668 670 693 703 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 100.0 100.0 100.0 98.0 96.0 94.0 86.0 80.0 74.0 |
| | |
| | |
|125 MG/L | 100.0 100.0 100.0 98.0 96.0 94.0 90.0 88.0 76.0 72.0 |
| | |
| | |
|1000MG/L | 100.0 100.0 100.0 100.0 98.0 98.0 94.0 86.0 74.0 66.0 |
| | |
| | |
|2000MG/L | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 96.0 90.0 82.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 125 MG/L 1000MG/L 2000MG/L |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.0% 72.0% 66.0% 82.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.368N P=0.945 P=0.498 P=0.426N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 599.7 578.7 606.1 629.6 |
|NATURAL DEATHS (C) | (26.7) (29.6) (19.7) (24.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 695.4 686.9 687.2 711.1 |
|(STANDARD ERROR) | (10.5) (12.6) (10.6) ( 6.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
125 MG/L = 2
1000MG/L = 3
2000MG/L = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
104 +
|
| 1 3 1 4 2
| 3 1 4 13 2 2
96 + 134 1 22
| 4 11 4 22
P | 1 1 3232
E | 1 4132 4 2
R 88 + 1 4 22 1 4
C | 32211
E | 23 23
N | 1232 3 1
T 80 + 42 23
| 33 11
S | 224
U | 34 31 1
R 72 + 2 424
V | 223
I | 44
V | 223
A 64 + 223
L | 443 3
| 44
| 22
56 + 22 4
| 2 2
|
|
48 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 20 obs hidden.
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
125 MG/L = 2
1000MG/L = 3
2000MG/L = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1 4
|
| 2 3 1 1 4 3 4
| 22 1 13 4 4
95 +
| 2 13 31
P | 2 23113 44
E |
R 90 + 2 13 3 1 4 4
C |
E | 2 2
N | 3 1 312 4 4
T 85 +
| 1221 4 4
S | 3 321 1 4 4
U |
R 80 + 33 1 1
V |
I | 2 2
V | 3 32 211
A 75 +
L | 3 3 2 1 1
| 2 2
|
70 + 33
|
|
| 3 3
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.
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