TDMS Study 96010-03 Pathology Tables
NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 FINAL#1/RATS Facility: Southern Research Institute Chemical CAS #: 7775-09-9 Lock Date: 10/16/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to days on test Page 1 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 6| 1| 5| 6| 9| 9| 2| 4| 6| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 2| 1| 5| 6| 4| 5| 3| 4| 1| 7| 8| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/L | 4| 1| 1| 0| 4| 3| 4| 2| 4| 0| 4| 3| 1| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| | 2| 8| 0| 3| 5| 6| 7| 7| 6| 5| 0| 0| 1| 1| 2| 4| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Adenoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 6| 1| 5| 6| 9| 9| 2| 4| 6| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 2| 1| 5| 6| 4| 5| 3| 4| 1| 7| 8| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/L | 4| 1| 1| 0| 4| 3| 4| 2| 4| 0| 4| 3| 1| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| | 2| 8| 0| 3| 5| 6| 7| 7| 6| 5| 0| 0| 1| 1| 2| 4| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + M + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X| Pars Distalis, Carcinoma | X | Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + A A + + + + + + + + + + + M + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X X X X | C-Cell, Carcinoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X | Carcinoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma Stromal | | Endometrium, Polyp Stromal | X X | __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 6| 1| 5| 6| 9| 9| 2| 4| 6| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 2| 1| 5| 6| 4| 5| 3| 4| 1| 7| 8| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/L | 4| 1| 1| 0| 4| 3| 4| 2| 4| 0| 4| 3| 1| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| | 2| 8| 0| 3| 5| 6| 7| 7| 6| 5| 0| 0| 1| 1| 2| 4| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Endometrium, Polyp Stromal, Multiple | X| |__________________________________________________________________________| Vagina | + + + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M + M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X | Carcinoma, Multiple | X | Fibroadenoma | X X X X X X X X X | Fibroadenoma, Multiple | X X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | X | Trichoepithelioma | X | Pinna, Neural Crest Tumor | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 6| 1| 5| 6| 9| 9| 2| 4| 6| 1| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 2| 1| 5| 6| 4| 5| 3| 4| 1| 7| 8| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/L | 4| 1| 1| 0| 4| 3| 4| 2| 4| 0| 4| 3| 1| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| | 2| 8| 0| 3| 5| 6| 7| 7| 6| 5| 0| 0| 1| 1| 2| 4| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + M + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Mammary Gland | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/L | 3| 3| 3| 4| 4| 5| 2| 2| 2| 0| 0| 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 3| 4| 4| 4| L | | 7| 8| 9| 8| 9| 0| 6| 8| 9| 6| 7| 8| 9| 6| 7| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leiomyosarcoma | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Mesentery | + + + + + +| 18 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Adenoma | X | 2 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/L | 3| 3| 3| 4| 4| 5| 2| 2| 2| 0| 0| 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 3| 4| 4| 4| L | | 7| 8| 9| 8| 9| 0| 6| 8| 9| 6| 7| 8| 9| 6| 7| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | X X | 2 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 2 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X X X X| 23 | Pars Distalis, Carcinoma | | 1 | Pars Intermedia, Adenoma | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Bilateral, C-Cell, Adenoma | X | 1 | C-Cell, Adenoma | X X X X X X | 11 | C-Cell, Carcinoma | | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X X X X X X X| 11 | Carcinoma | X X | 3 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/L | 3| 3| 3| 4| 4| 5| 2| 2| 2| 0| 0| 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 3| 4| 4| 4| L | | 7| 8| 9| 8| 9| 0| 6| 8| 9| 6| 7| 8| 9| 6| 7| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor Benign | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma Stromal | X | 1 | Endometrium, Polyp Stromal | X X X X X X| 8 | Endometrium, Polyp Stromal, Multiple | | 1 | |__________________________________________________________________________|____________| Vagina | + + | 6 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + +| 36 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M + M M M M M M M M + M M M M M + M M M M| 4 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 3 | Carcinoma | | 2 | Carcinoma, Multiple | | 1 | Fibroadenoma | X X X X X X X X X X X X X X| 23 | Fibroadenoma, Multiple | X X X X | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/L | 3| 3| 3| 4| 4| 5| 2| 2| 2| 0| 0| 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 3| 4| 4| 4| L | | 7| 8| 9| 8| 9| 0| 6| 8| 9| 6| 7| 8| 9| 6| 7| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Carcinoma | | 1 | Trichoepithelioma | X | 2 | Pinna, Neural Crest Tumor | | 1 | Subcutaneous Tissue, Fibroma | X X X | 4 | Subcutaneous Tissue, Lipoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Alveolar/Bronchiolar Carcinoma | X | 1 | Carcinoma, Metastatic, Mammary Gland | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/L | 3| 3| 3| 4| 4| 5| 2| 2| 2| 0| 0| 0| 0| 1| 1| 1| 2| 3| 3| 3| 3| 3| 4| 4| 4| L | | 7| 8| 9| 8| 9| 0| 6| 8| 9| 6| 7| 8| 9| 6| 7| 9| 0| 1| 2| 3| 4| 5| 1| 3| 4| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 2| 3| 1| 4| 6| 2| 2| 3| 3| 4| 5| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 3| 3| 1| 1| 3| 3| 6| 6| 9| 4| 7| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 125 MG/L | 6| 9| 8| 7| 8| 5| 8| 5| 9| 8| 5| 6| 7| 7| 5| 5| 5| 5| 6| 6| 6| 6| 9| 6| 6| | 5| 0| 6| 6| 7| 8| 1| 4| 5| 2| 2| 0| 1| 8| 7| 1| 3| 5| 1| 2| 3| 4| 9| 6| 7| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + A + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + A A + + A + + + + + + + + + + + + + + +| Leiomyoma | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X | Histiocytic Sarcoma | X | Histiocytic Sarcoma, Metastatic, | | Skeletal Muscle | | |__________________________________________________________________________| Mesentery | + + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + | Odontoma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 11 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 2| 3| 1| 4| 6| 2| 2| 3| 3| 4| 5| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 3| 3| 1| 1| 3| 3| 6| 6| 9| 4| 7| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 125 MG/L | 6| 9| 8| 7| 8| 5| 8| 5| 9| 8| 5| 6| 7| 7| 5| 5| 5| 5| 6| 6| 6| 6| 9| 6| 6| | 5| 0| 6| 6| 7| 8| 1| 4| 5| 2| 2| 0| 1| 8| 7| 1| 3| 5| 1| 2| 3| 4| 9| 6| 7| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X| Pars Distalis, Carcinoma | X X | Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + A A + + A + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | | C-Cell, Adenoma | X X X X| C-Cell, Carcinoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | Mediastinum, Carcinoma, Metastatic, | | Thyroid Gland | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 12 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 2| 3| 1| 4| 6| 2| 2| 3| 3| 4| 5| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 3| 3| 1| 1| 3| 3| 6| 6| 9| 4| 7| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 125 MG/L | 6| 9| 8| 7| 8| 5| 8| 5| 9| 8| 5| 6| 7| 7| 5| 5| 5| 5| 6| 6| 6| 6| 9| 6| 6| | 5| 0| 6| 6| 7| 8| 1| 4| 5| 2| 2| 0| 1| 8| 7| 1| 3| 5| 1| 2| 3| 4| 9| 6| 7| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Polyp Stromal | X X | |__________________________________________________________________________| Vagina | + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M + M M M M M M M + + M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + A + + + + + + + + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Fibroadenoma | X X X X X X X X X X X | Fibroadenoma, Multiple | X | Histiocytic Sarcoma, Metastatic, | | Skeletal Muscle | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Carcinoma, | | __________________________________________|__________________________________________________________________________| Page 13 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 2| 3| 1| 4| 6| 2| 2| 3| 3| 4| 5| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 3| 3| 1| 1| 3| 3| 6| 6| 9| 4| 7| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 125 MG/L | 6| 9| 8| 7| 8| 5| 8| 5| 9| 8| 5| 6| 7| 7| 5| 5| 5| 5| 6| 6| 6| 6| 9| 6| 6| | 5| 0| 6| 6| 7| 8| 1| 4| 5| 2| 2| 0| 1| 8| 7| 1| 3| 5| 1| 2| 3| 4| 9| 6| 7| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Metastatic, Mammary Gland | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Histiocytic | | Sarcoma | X | Subcutaneous Tissue, Histiocytic | | Sarcoma, Metastatic, Skeletal | | Muscle | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | |__________________________________________________________________________| Skeletal Muscle | | Histiocytic Sarcoma | | Rhabdomyosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | |__________________________________________________________________________| Peripheral Nerve | + + | |__________________________________________________________________________| Spinal Cord | + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Histiocytic Sarcoma | X | Histiocytic Sarcoma, Metastatic, | | Skeletal Muscle | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 14 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 2| 3| 1| 4| 6| 2| 2| 3| 3| 4| 5| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 3| 3| 1| 1| 3| 3| 6| 6| 9| 4| 7| 4| 7| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 125 MG/L | 6| 9| 8| 7| 8| 5| 8| 5| 9| 8| 5| 6| 7| 7| 5| 5| 5| 5| 6| 6| 6| 6| 9| 6| 6| | 5| 0| 6| 6| 7| 8| 1| 4| 5| 2| 2| 0| 1| 8| 7| 1| 3| 5| 1| 2| 3| 4| 9| 6| 7| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X | __________________________________________|__________________________________________________________________________| Page 15 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 125 MG/L | 6| 6| 7| 8| 8| 9| 9| 9| 9| 5| 5| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| L | | 8| 9| 0| 8| 9| 1| 2| 3| 4| 6| 9| 2| 3| 4| 5| 7| 9| 0| 3| 4| 5| 6| 7| 8| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Leiomyoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma | | 1 | Histiocytic Sarcoma | | 1 | Histiocytic Sarcoma, Metastatic, | | | Skeletal Muscle | X | 1 | |__________________________________________________________________________|____________| Mesentery | + + + | 10 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Tooth | | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 125 MG/L | 6| 6| 7| 8| 8| 9| 9| 9| 9| 5| 5| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| L | | 8| 9| 0| 8| 9| 1| 2| 3| 4| 6| 9| 2| 3| 4| 5| 7| 9| 0| 3| 4| 5| 6| 7| 8| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Odontoma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + M + +| 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X X X X X| 18 | Pars Distalis, Carcinoma | X | 3 | Pars Intermedia, Adenoma | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Bilateral, C-Cell, Adenoma | X X | 2 | C-Cell, Adenoma | X X X X | 8 | C-Cell, Carcinoma | X | 3 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 125 MG/L | 6| 6| 7| 8| 8| 9| 9| 9| 9| 5| 5| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| L | | 8| 9| 0| 8| 9| 1| 2| 3| 4| 6| 9| 2| 3| 4| 5| 7| 9| 0| 3| 4| 5| 6| 7| 8| 0| | _____________________________________________________________________________________________________________________|____________| GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 2 | Mediastinum, Carcinoma, Metastatic, | | | Thyroid Gland | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X| 5 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Endometrium, Polyp Stromal | X X X X X X | 8 | |__________________________________________________________________________|____________| Vagina | + | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + +| 34 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M + M M M M M M M M + M M M M M M M M M M + M M| 6 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 125 MG/L | 6| 6| 7| 8| 8| 9| 9| 9| 9| 5| 5| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| L | | 8| 9| 0| 8| 9| 1| 2| 3| 4| 6| 9| 2| 3| 4| 5| 7| 9| 0| 3| 4| 5| 6| 7| 8| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 1 | Fibroadenoma | X X X X X X X X X X X X X X X| 26 | Fibroadenoma, Multiple | X X | 3 | Histiocytic Sarcoma, Metastatic, | | | Skeletal Muscle | X | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Carcinoma, | | | Metastatic, Mammary Gland | | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | | 1 | Subcutaneous Tissue, Histiocytic | | | Sarcoma, Metastatic, Skeletal | | | Muscle | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + +| 2 | Histiocytic Sarcoma | X | 1 | Rhabdomyosarcoma | X| 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pituitary | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 19 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 125 MG/L | 6| 6| 7| 8| 8| 9| 9| 9| 9| 5| 5| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| L | | 8| 9| 0| 8| 9| 1| 2| 3| 4| 6| 9| 2| 3| 4| 5| 7| 9| 0| 3| 4| 5| 6| 7| 8| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | | | | Gland | X | 2 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 3 | |__________________________________________________________________________|____________| Spinal Cord | + | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Histiocytic Sarcoma | | 1 | Histiocytic Sarcoma, Metastatic, | | | Skeletal Muscle | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | _____________________________________________________________________________________________________________________ T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 125 MG/L | 6| 6| 7| 8| 8| 9| 9| 9| 9| 5| 5| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 0| L | | 8| 9| 0| 8| 9| 1| 2| 3| 4| 6| 9| 2| 3| 4| 5| 7| 9| 0| 3| 4| 5| 6| 7| 8| 0| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | X | 2 | Leukemia Mononuclear | X X X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 1| 1| 4| 7| 8| 8| 1| 1| 2| 3| 3| 5| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 1| 4| 7| 3| 7| 7| 5| 5| 6| 6| 6| 1| 9| 9| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000MG/L | 5| 2| 0| 1| 2| 3| 4| 2| 4| 3| 0| 0| 2| 1| 4| 1| 3| 2| 2| 2| 3| 3| 3| 3| 4| | 0| 8| 4| 8| 4| 5| 1| 5| 9| 4| 6| 9| 0| 1| 6| 2| 8| 6| 7| 9| 0| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + A + + + A A + + + + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + A + + + A A + + + + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + A A + + A A + + + + + A + + + A + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + A A + + + + + A + + + A + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + A A + + A A + + + + + A + + + A + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + A A + + A A + + + + + A + + + A + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Mesentery | + + + + + + + + + | |__________________________________________________________________________| Oral Mucosa | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 22 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 1| 1| 4| 7| 8| 8| 1| 1| 2| 3| 3| 5| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 1| 4| 7| 3| 7| 7| 5| 5| 6| 6| 6| 1| 9| 9| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000MG/L | 5| 2| 0| 1| 2| 3| 4| 2| 4| 3| 0| 0| 2| 1| 4| 1| 3| 2| 2| 2| 3| 3| 3| 3| 4| | 0| 8| 4| 8| 4| 5| 1| 5| 9| 4| 6| 9| 0| 1| 6| 2| 8| 6| 7| 9| 0| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X | |__________________________________________________________________________| Thyroid Gland | + + A A A + + A A + + + + + A + + + A + + + + + +| C-Cell, Adenoma | X X X X | C-Cell, Carcinoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + + + + | Mediastinum, Carcinoma, Metastatic, | | Zymbal's Gland | X | Mediastinum, Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X X X| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + A + + + + + +| |__________________________________________________________________________| Oviduct | + + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + | Endometrium, Polyp Stromal | X X X | Endometrium, Polyp Stromal, Multiple | X X | __________________________________________|__________________________________________________________________________| Page 23 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 1| 1| 4| 7| 8| 8| 1| 1| 2| 3| 3| 5| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 1| 4| 7| 3| 7| 7| 5| 5| 6| 6| 6| 1| 9| 9| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000MG/L | 5| 2| 0| 1| 2| 3| 4| 2| 4| 3| 0| 0| 2| 1| 4| 1| 3| 2| 2| 2| 3| 3| 3| 3| 4| | 0| 8| 4| 8| 4| 5| 1| 5| 9| 4| 6| 9| 0| 1| 6| 2| 8| 6| 7| 9| 0| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Vagina | + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + | Mediastinal, Histiocytic Sarcoma | X | |__________________________________________________________________________| Lymph Node, Mandibular | M M M + M M M M M M M M M M M + M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + M + + + + + + M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X X X X X X X X X| Fibroadenoma, Multiple | X X X X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibroma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Mesothelioma Malignant, Metastatic, | | Mesentery | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 1| 1| 4| 7| 8| 8| 1| 1| 2| 3| 3| 5| 9| 9| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 1| 1| 4| 7| 3| 7| 7| 5| 5| 6| 6| 6| 1| 9| 9| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1000MG/L | 5| 2| 0| 1| 2| 3| 4| 2| 4| 3| 0| 0| 2| 1| 4| 1| 3| 2| 2| 2| 3| 3| 3| 3| 4| | 0| 8| 4| 8| 4| 5| 1| 5| 9| 4| 6| 9| 0| 1| 6| 2| 8| 6| 7| 9| 0| 6| 7| 9| 0| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + A + + + + + + A + + + A + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lacrimal Gland | | |__________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + A + + + A + + + + + + + + + A + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X | Lymphoma Malignant | X | Mesothelioma Malignant | X | __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000MG/L | 4| 4| 4| 4| 4| 4| 3| 3| 3| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 0| 0| 1| 1| 1| 1| L | | 2| 3| 4| 5| 7| 8| 1| 2| 3| 1| 2| 3| 5| 6| 7| 9| 1| 2| 3| 7| 8| 0| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Mesentery | + + + + | 13 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Tooth | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000MG/L | 4| 4| 4| 4| 4| 4| 3| 3| 3| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 0| 0| 1| 1| 1| 1| L | | 2| 3| 4| 5| 7| 8| 1| 2| 3| 1| 2| 3| 5| 6| 7| 9| 1| 2| 3| 7| 8| 0| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | | | | Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X X | 17 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 | C-Cell, Adenoma | X X X X X X X| 11 | C-Cell, Carcinoma | | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 4 | Mediastinum, Carcinoma, Metastatic, | | | Zymbal's Gland | | 1 | Mediastinum, Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X X X | 12 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000MG/L | 4| 4| 4| 4| 4| 4| 3| 3| 3| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 0| 0| 1| 1| 1| 1| L | | 2| 3| 4| 5| 7| 8| 1| 2| 3| 1| 2| 3| 5| 6| 7| 9| 1| 2| 3| 7| 8| 0| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Oviduct | | 2 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Endometrium, Polyp Stromal | X X X X | 7 | Endometrium, Polyp Stromal, Multiple | | 2 | |__________________________________________________________________________|____________| Vagina | + | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + +| 30 | Mediastinal, Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M + M + M M| 4 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroadenoma | X X X X X X X X X X X X X| 23 | Fibroadenoma, Multiple | X X X | 8 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000MG/L | 4| 4| 4| 4| 4| 4| 3| 3| 3| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 0| 0| 1| 1| 1| 1| L | | 2| 3| 4| 5| 7| 8| 1| 2| 3| 1| 2| 3| 5| 6| 7| 9| 1| 2| 3| 7| 8| 0| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibroma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Mesothelioma Malignant, Metastatic, | | | Mesentery | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lacrimal Gland | + | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 4| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 1000MG/L | 4| 4| 4| 4| 4| 4| 3| 3| 3| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 0| 0| 1| 1| 1| 1| L | | 2| 3| 4| 5| 7| 8| 1| 2| 3| 1| 2| 3| 5| 6| 7| 9| 1| 2| 3| 7| 8| 0| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X | 13 | Lymphoma Malignant | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 4| 3| 3| 4| 6| 7| 9| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 2| 5| 6| 4| 8| 0| 3| 3| 9| 9| 9| 9| 9| 9| 9| 9| 0| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2000MG/L | 5| 8| 9| 8| 6| 9| 6| 7| 8| 7| 7| 7| 7| 8| 8| 8| 9| 9| 5| 5| 5| 5| 5| 5| 5| | 1| 0| 1| 8| 3| 7| 5| 0| 1| 6| 7| 8| 9| 6| 7| 9| 0| 5| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + A + + + A A + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + A A + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + A + A + A A + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + A + + + A A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Mesentery | + + + + + + + + | Carcinoma | X | |__________________________________________________________________________| Oral Mucosa | + | Squamous Cell Carcinoma | X | |__________________________________________________________________________| Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 4| 3| 3| 4| 6| 7| 9| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 2| 5| 6| 4| 8| 0| 3| 3| 9| 9| 9| 9| 9| 9| 9| 9| 0| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2000MG/L | 5| 8| 9| 8| 6| 9| 6| 7| 8| 7| 7| 7| 7| 8| 8| 8| 9| 9| 5| 5| 5| 5| 5| 5| 5| | 1| 0| 1| 8| 3| 7| 5| 0| 1| 6| 7| 8| 9| 6| 7| 9| 0| 5| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Complex | | Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + M + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X X| Pars Distalis, Adenoma, Multiple | X | Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + A + + + A A + + + + + + + + + A + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | X X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + + + + + | Mediastinum, Sarcoma | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X| __________________________________________|__________________________________________________________________________| Page 32 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 4| 3| 3| 4| 6| 7| 9| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 2| 5| 6| 4| 8| 0| 3| 3| 9| 9| 9| 9| 9| 9| 9| 9| 0| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2000MG/L | 5| 8| 9| 8| 6| 9| 6| 7| 8| 7| 7| 7| 7| 8| 8| 8| 9| 9| 5| 5| 5| 5| 5| 5| 5| | 1| 0| 1| 8| 3| 7| 5| 0| 1| 6| 7| 8| 9| 6| 7| 9| 0| 5| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Sarcoma | X | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Mesentery | X | Endometrium, Polyp Stromal | X X X X X | Endometrium, Sarcoma | X | |__________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Sarcoma | X | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M + M + M M M M + M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | X | |__________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| Sarcoma | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X | Fibroadenoma | X X X X X X X X X X X X X X | Fibroadenoma, Multiple | X X| __________________________________________|__________________________________________________________________________| Page 33 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 4| 3| 3| 4| 6| 7| 9| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 2| 5| 6| 4| 8| 0| 3| 3| 9| 9| 9| 9| 9| 9| 9| 9| 0| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2000MG/L | 5| 8| 9| 8| 6| 9| 6| 7| 8| 7| 7| 7| 7| 8| 8| 8| 9| 9| 5| 5| 5| 5| 5| 5| 5| | 1| 0| 1| 8| 3| 7| 5| 0| 1| 6| 7| 8| 9| 6| 7| 9| 0| 5| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | X | |__________________________________________________________________________| Lacrimal Gland | + | |__________________________________________________________________________| Zymbal's Gland | + | __________________________________________|__________________________________________________________________________| Page 34 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 7| 4| 3| 3| 4| 6| 7| 9| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| | 5| 2| 5| 6| 4| 8| 0| 3| 3| 9| 9| 9| 9| 9| 9| 9| 9| 0| 5| 5| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2000MG/L | 5| 8| 9| 8| 6| 9| 6| 7| 8| 7| 7| 7| 7| 8| 8| 8| 9| 9| 5| 5| 5| 5| 5| 5| 5| | 1| 0| 1| 8| 3| 7| 5| 0| 1| 6| 7| 8| 9| 6| 7| 9| 0| 5| 2| 3| 4| 5| 6| 7| 8| __________________________________________|__________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + A + A + + + + + + + + + + + + A + + + + + + +| Sarcoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Papilloma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________|__________________________________________________________________________| Page 35 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2000MG/L | 5| 6| 7| 7| 7| 7| 7| 9| 9| 9| 0| 6| 6| 6| 8| 8| 8| 8| 9| 9| 9| 6| 6| 6| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 2| 3| 4| 5| 2| 3| 4| 6| 7| 8| 9| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + I + + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + +| 16 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2000MG/L | 5| 6| 7| 7| 7| 7| 7| 9| 9| 9| 0| 6| 6| 6| 8| 8| 8| 8| 9| 9| 9| 6| 6| 6| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 2| 3| 4| 5| 2| 3| 4| 6| 7| 8| 9| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Complex | X| 1 | Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X X X X| 24 | Pars Distalis, Adenoma, Multiple | | 1 | Pars Intermedia, Adenoma | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | C-Cell, Adenoma | X X X X X X| 9 | C-Cell, Carcinoma | X X | 3 | Follicular Cell, Adenoma | | 2 | Follicular Cell, Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 6 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2000MG/L | 5| 6| 7| 7| 7| 7| 7| 9| 9| 9| 0| 6| 6| 6| 8| 8| 8| 8| 9| 9| 9| 6| 6| 6| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 2| 3| 4| 5| 2| 3| 4| 6| 7| 8| 9| | _____________________________________________________________________________________________________________________|____________| GENERAL BODY SYSTEM - cont | | | | | | Mediastinum, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Adenoma | X X X | 4 | Sarcoma | | 1 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Mesentery | | 1 | Endometrium, Polyp Stromal | X X | 7 | Endometrium, Sarcoma | | 1 | |__________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + +| 39 | Mediastinal, Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M + M M M M M M M M M M M M + M M M M M M M M| 5 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2000MG/L | 5| 6| 7| 7| 7| 7| 7| 9| 9| 9| 0| 6| 6| 6| 8| 8| 8| 8| 9| 9| 9| 6| 6| 6| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 2| 3| 4| 5| 2| 3| 4| 6| 7| 8| 9| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Thymus | + + + + + + + + + + + + + + + + + + + + + I + + +| 48 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 2 | Carcinoma | X | 2 | Fibroadenoma | X X X X X X X X X X X X X| 27 | Fibroadenoma, Multiple | X X X X | 6 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Sarcoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 2000MG/L | 5| 6| 7| 7| 7| 7| 7| 9| 9| 9| 0| 6| 6| 6| 8| 8| 8| 8| 9| 9| 9| 6| 6| 6| 6| L | | 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 4| 2| 3| 4| 5| 2| 3| 4| 6| 7| 8| 9| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Lacrimal Gland | + | 2 | |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Sarcoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 6| 0| 1| 4| 7| 3| 3| 3| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 3| 9| 3| 1| 5| 4| 0| 6| 6| 5| 9| 5| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/L | 1| 3| 3| 2| 3| 3| 0| 4| 2| 4| 2| 5| 4| 4| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| | 2| 9| 1| 0| 8| 2| 7| 5| 6| 0| 4| 0| 1| 6| 3| 4| 5| 6| 7| 8| 1| 2| 3| 8| 9| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + A + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + A + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A + A + + + + + + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + A + A + + + + + + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + A + A + + + + + + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + | Histiocytic Sarcoma | X | Osteosarcoma | X | |__________________________________________________________________________| Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Malignant | X | |__________________________________________________________________________| Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | Aorta, Osteosarcoma | X | __________________________________________|__________________________________________________________________________| Page 41 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 6| 0| 1| 4| 7| 3| 3| 3| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 3| 9| 3| 1| 5| 4| 0| 6| 6| 5| 9| 5| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/L | 1| 3| 3| 2| 3| 3| 0| 4| 2| 4| 2| 5| 4| 4| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| | 2| 9| 1| 0| 8| 2| 7| 5| 6| 0| 4| 0| 1| 6| 3| 4| 5| 6| 7| 8| 1| 2| 3| 8| 9| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Adrenal Medulla | + + + A + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + A + + + + + + + A + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X | |__________________________________________________________________________| Thyroid Gland | + A + A + + + + + + + + + A + + + + + + + + + + +| C-Cell, Adenoma | X X X X X X| C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + + +| Abdominal, Paraganglioma | X | Pelvic, Leiomyoma | X| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 42 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 6| 0| 1| 4| 7| 3| 3| 3| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 3| 9| 3| 1| 5| 4| 0| 6| 6| 5| 9| 5| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/L | 1| 3| 3| 2| 3| 3| 0| 4| 2| 4| 2| 5| 4| 4| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| | 2| 9| 1| 0| 8| 2| 7| 5| 6| 0| 4| 0| 1| 6| 3| 4| 5| 6| 7| 8| 1| 2| 3| 8| 9| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Preputial Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Carcinoma | X X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, | | Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X | Interstitial Cell, Adenoma, Multiple | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Deep Cervical, Histiocytic Sarcoma | X | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M + + M M M M M M M M M M M M M M M + M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + A + + + + + + + + + + A + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Thymus | + + + A + + + + M + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M + + A + + + + M + + + + + + + + + + + + + + + +| Fibroadenoma | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 43 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 6| 0| 1| 4| 7| 3| 3| 3| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 3| 9| 3| 1| 5| 4| 0| 6| 6| 5| 9| 5| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/L | 1| 3| 3| 2| 3| 3| 0| 4| 2| 4| 2| 5| 4| 4| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| | 2| 9| 1| 0| 8| 2| 7| 5| 6| 0| 4| 0| 1| 6| 3| 4| 5| 6| 7| 8| 1| 2| 3| 8| 9| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X X X | Trichoepithelioma | X | Subcutaneous Tissue, Fibroma | X X X X X| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Neural Crest | | Tumor | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + | |__________________________________________________________________________| Spinal Cord | + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Histiocytic Sarcoma, Metastatic, | | Uncertain Primary Site | X | Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Nose | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 44 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 3| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 6| 0| 1| 4| 7| 3| 3| 3| 9| 9| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | 1| 3| 9| 3| 1| 5| 4| 0| 6| 6| 5| 9| 5| 6| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/L | 1| 3| 3| 2| 3| 3| 0| 4| 2| 4| 2| 5| 4| 4| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| | 2| 9| 1| 0| 8| 2| 7| 5| 6| 0| 4| 0| 1| 6| 3| 4| 5| 6| 7| 8| 1| 2| 3| 8| 9| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + A + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + A + A + + + + + + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + A + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X X X X | Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/L | 2| 2| 3| 4| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 0| 0| 0| 2| 2| L | | 5| 7| 3| 9| 0| 1| 9| 1| 8| 9| 0| 4| 5| 6| 7| 2| 3| 4| 7| 8| 4| 5| 6| 2| 3| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 19 | Histiocytic Sarcoma | | 1 | Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Schwannoma Malignant | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/L | 2| 2| 3| 4| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 0| 0| 0| 2| 2| L | | 5| 7| 3| 9| 0| 1| 9| 1| 8| 9| 0| 4| 5| 6| 7| 2| 3| 4| 7| 8| 4| 5| 6| 2| 3| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 1 | Aorta, Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pheochromocytoma Malignant | X X | 3 | Pheochromocytoma Benign | X X X X X | 6 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 3 | Carcinoma | X X | 2 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Adenoma | X X X X X X X X X X X X | 16 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | C-Cell, Adenoma | X X X | 9 | C-Cell, Carcinoma | X X | 2 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + + | 5 | Abdominal, Paraganglioma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/L | 2| 2| 3| 4| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 0| 0| 0| 2| 2| L | | 5| 7| 3| 9| 0| 1| 9| 1| 8| 9| 0| 4| 5| 6| 7| 2| 3| 4| 7| 8| 4| 5| 6| 2| 3| | _____________________________________________________________________________________________________________________|____________| GENERAL BODY SYSTEM - cont | | | | | | Pelvic, Leiomyoma | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Adenoma | X | 1 | Carcinoma | X | 3 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, | | | Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X X X| 40 | Interstitial Cell, Adenoma | X | 2 | Interstitial Cell, Adenoma, Multiple | X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + +| 34 | Histiocytic Sarcoma | | 1 | Deep Cervical, Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 3 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/L | 2| 2| 3| 4| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 0| 0| 0| 2| 2| L | | 5| 7| 3| 9| 0| 1| 9| 1| 8| 9| 0| 4| 5| 6| 7| 2| 3| 4| 7| 8| 4| 5| 6| 2| 3| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + M + + + + + + + + + M + + + + + + + + + + + +| 45 | Fibroadenoma | X X | 2 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 4 | Trichoepithelioma | | 1 | Subcutaneous Tissue, Fibroma | X X X X| 9 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Neural Crest | | | Tumor | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Peripheral Nerve | | 2 | |__________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/L | 2| 2| 3| 4| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 0| 0| 0| 2| 2| L | | 5| 7| 3| 9| 0| 1| 9| 1| 8| 9| 0| 4| 5| 6| 7| 2| 3| 4| 7| 8| 4| 5| 6| 2| 3| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Alveolar/Bronchiolar Carcinoma | X X| 2 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | Histiocytic Sarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X X X X | 13 | Lymphoma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 6| 7| 8| 0| 1| 1| 3| 5| 6| 6| 6| 7| 9| 9| 9| 0| 1| 1| 1| 2| 2| 2| 2| | 2| 5| 2| 4| 2| 5| 4| 9| 8| 2| 0| 3| 8| 2| 3| 5| 9| 3| 4| 4| 4| 1| 6| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 125 MG/L | 5| 8| 7| 7| 9| 8| 6| 6| 5| 6| 5| 6| 8| 9| 5| 9| 8| 5| 8| 8| 9| 6| 6| 5| 5| | 2| 5| 1| 8| 2| 3| 6| 2| 4| 4| 5| 5| 0| 1| 1| 9| 4| 8| 8| 9| 4| 3| 9| 3| 7| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + A + A + A + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + A + A + A + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + A + A + A + A + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + A + A + A + A + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + A + A + A + A + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + A + A + A + A + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Adenoma | X| Histiocytic Sarcoma | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | Hemangiosarcoma, Metastatic, Liver | | Histiocytic Sarcoma | | |__________________________________________________________________________| Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Liver | | Acinus, Adenoma | X X| Acinus, Adenoma, Multiple | | Acinus, Carcinoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + A + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 51 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 6| 7| 8| 0| 1| 1| 3| 5| 6| 6| 6| 7| 9| 9| 9| 0| 1| 1| 1| 2| 2| 2| 2| | 2| 5| 2| 4| 2| 5| 4| 9| 8| 2| 0| 3| 8| 2| 3| 5| 9| 3| 4| 4| 4| 1| 6| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 125 MG/L | 5| 8| 7| 7| 9| 8| 6| 6| 5| 6| 5| 6| 8| 9| 5| 9| 8| 5| 8| 8| 9| 6| 6| 5| 5| | 2| 5| 1| 8| 2| 3| 6| 2| 4| 4| 5| 5| 0| 1| 1| 9| 4| 8| 8| 9| 4| 3| 9| 3| 7| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Tongue | + | Squamous Cell Carcinoma | X | |__________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + A + + + + + + + + + + + + + + + + + +| Ganglioneuroma | X | Pheochromocytoma Benign | X | Bilateral, Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X | Pars Intermedia, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + A + A + A + A + + A + + + + + + + + + + A + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 52 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 6| 7| 8| 0| 1| 1| 3| 5| 6| 6| 6| 7| 9| 9| 9| 0| 1| 1| 1| 2| 2| 2| 2| | 2| 5| 2| 4| 2| 5| 4| 9| 8| 2| 0| 3| 8| 2| 3| 5| 9| 3| 4| 4| 4| 1| 6| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 125 MG/L | 5| 8| 7| 7| 9| 8| 6| 6| 5| 6| 5| 6| 8| 9| 5| 9| 8| 5| 8| 8| 9| 6| 6| 5| 5| | 2| 5| 1| 8| 2| 3| 6| 2| 4| 4| 5| 5| 0| 1| 1| 9| 4| 8| 8| 9| 4| 3| 9| 3| 7| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | Tissue NOS | + + + + + + | Mediastinum, Carcinoma, Metastatic, | | Zymbal's Gland | X | Mediastinum, Squamous Cell Carcinoma,| | Metastatic, Lung | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Penis | + | |__________________________________________________________________________| Preputial Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | |__________________________________________________________________________| Prostate | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, | | Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X | Interstitial Cell, Adenoma, Multiple | X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + A + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + +| Mediastinal, Carcinoma, Metastatic, | | Zymbal's Gland | X | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M + M M M M M M M| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 53 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 6| 7| 8| 0| 1| 1| 3| 5| 6| 6| 6| 7| 9| 9| 9| 0| 1| 1| 1| 2| 2| 2| 2| | 2| 5| 2| 4| 2| 5| 4| 9| 8| 2| 0| 3| 8| 2| 3| 5| 9| 3| 4| 4| 4| 1| 6| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 125 MG/L | 5| 8| 7| 7| 9| 8| 6| 6| 5| 6| 5| 6| 8| 9| 5| 9| 8| 5| 8| 8| 9| 6| 6| 5| 5| | 2| 5| 1| 8| 2| 3| 6| 2| 4| 4| 5| 5| 0| 1| 1| 9| 4| 8| 8| 9| 4| 3| 9| 3| 7| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +| Capsule, Carcinoma, Metastatic, | | Pancreas | | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M I + + + + + + + + +| Carcinoma, Metastatic, Zymbal's Gland| X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + M + M A M M + + + + M + + + + + + M + + + + + +| Carcinoma | X | Fibroadenoma | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | | Basal Cell Carcinoma, Multiple | | Keratoacanthoma | X X | Subcutaneous Tissue, Fibroma | X X X | Subcutaneous Tissue, Fibroma, | | Multiple | X | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Histiocytic | | Sarcoma | | Subcutaneous Tissue, Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Periosteum, Cranium, Fibrosarcoma, | | Metastatic, Skin | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 54 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 6| 7| 8| 0| 1| 1| 3| 5| 6| 6| 6| 7| 9| 9| 9| 0| 1| 1| 1| 2| 2| 2| 2| | 2| 5| 2| 4| 2| 5| 4| 9| 8| 2| 0| 3| 8| 2| 3| 5| 9| 3| 4| 4| 4| 1| 6| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 125 MG/L | 5| 8| 7| 7| 9| 8| 6| 6| 5| 6| 5| 6| 8| 9| 5| 9| 8| 5| 8| 8| 9| 6| 6| 5| 5| | 2| 5| 1| 8| 2| 3| 6| 2| 4| 4| 5| 5| 0| 1| 1| 9| 4| 8| 8| 9| 4| 3| 9| 3| 7| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Glioma Malignant | X | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X| Squamous Cell Carcinoma | X | |__________________________________________________________________________| Nose | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + A + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + A + A + + + + + + + + + + + + + + + + + +| Retrobulbar, Fibrosarcoma, | | Metastatic, Skin | X | |__________________________________________________________________________| Harderian Gland | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lacrimal Gland | + | |__________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + A + A + + A + + + + + + + + + + A + +| Lipoma | | Renal Tubule, Adenoma | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 55 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 5| 6| 7| 8| 0| 1| 1| 3| 5| 6| 6| 6| 7| 9| 9| 9| 0| 1| 1| 1| 2| 2| 2| 2| | 2| 5| 2| 4| 2| 5| 4| 9| 8| 2| 0| 3| 8| 2| 3| 5| 9| 3| 4| 4| 4| 1| 6| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 125 MG/L | 5| 8| 7| 7| 9| 8| 6| 6| 5| 6| 5| 6| 8| 9| 5| 9| 8| 5| 8| 8| 9| 6| 6| 5| 5| | 2| 5| 1| 8| 2| 3| 6| 2| 4| 4| 5| 5| 0| 1| 1| 9| 4| 8| 8| 9| 4| 3| 9| 3| 7| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X X X X X X X X X X X| Mesothelioma Malignant | X | __________________________________________|__________________________________________________________________________| Page 56 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| A | 125 MG/L | 5| 7| 7| 7| 8| 8| 8| 9| 9| 9| 5| 6| 6| 7| 7| 7| 9| 9| 9| 0| 6| 6| 7| 7| 8| L | | 9| 2| 3| 4| 1| 2| 7| 0| 3| 5| 6| 7| 8| 5| 6| 7| 6| 7| 8| 0| 0| 1| 0| 9| 6| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Hepatocellular Adenoma | X X | 3 | Histiocytic Sarcoma | X | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 20 | Carcinoma, Metastatic, Pancreas | X | 1 | Hemangiosarcoma, Metastatic, Liver | X | 1 | Histiocytic Sarcoma | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma, Metastatic, Liver | X | 1 | Acinus, Adenoma | | 2 | Acinus, Adenoma, Multiple | X | 1 | Acinus, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 57 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| A | 125 MG/L | 5| 7| 7| 7| 8| 8| 8| 9| 9| 9| 5| 6| 6| 7| 7| 7| 9| 9| 9| 0| 6| 6| 7| 7| 8| L | | 9| 2| 3| 4| 1| 2| 7| 0| 3| 5| 6| 7| 8| 5| 6| 7| 6| 7| 8| 0| 0| 1| 0| 9| 6| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ganglioneuroma | | 1 | Pheochromocytoma Benign | X X| 3 | Bilateral, Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 4 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X X X X X| 15 | Pars Intermedia, Adenoma | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 58 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| A | 125 MG/L | 5| 7| 7| 7| 8| 8| 8| 9| 9| 9| 5| 6| 6| 7| 7| 7| 9| 9| 9| 0| 6| 6| 7| 7| 8| L | | 9| 2| 3| 4| 1| 2| 7| 0| 3| 5| 6| 7| 8| 5| 6| 7| 6| 7| 8| 0| 0| 1| 0| 9| 6| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | C-Cell, Adenoma | X X X X X X| 9 | C-Cell, Carcinoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | | 1 | |__________________________________________________________________________|____________| Tissue NOS | | 6 | Mediastinum, Carcinoma, Metastatic, | | | Zymbal's Gland | | 1 | Mediastinum, Squamous Cell Carcinoma,| | | Metastatic, Lung | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Penis | + | 2 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X X X X X| 6 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, | | | Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X X| 43 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| A | 125 MG/L | 5| 7| 7| 7| 8| 8| 8| 9| 9| 9| 5| 6| 6| 7| 7| 7| 9| 9| 9| 0| 6| 6| 7| 7| 8| L | | 9| 2| 3| 4| 1| 2| 7| 0| 3| 5| 6| 7| 8| 5| 6| 7| 6| 7| 8| 0| 0| 1| 0| 9| 6| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Interstitial Cell, Adenoma, Multiple | X | 5 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 24 | Mediastinal, Carcinoma, Metastatic, | | | Zymbal's Gland | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M + M M M M| 2 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Capsule, Carcinoma, Metastatic, | | | Pancreas | X | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 | Carcinoma | | 1 | Fibroadenoma | X | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Carcinoma | X | 1 | Basal Cell Carcinoma, Multiple | X | 1 | Keratoacanthoma | | 2 | Subcutaneous Tissue, Fibroma | X X X X X X | 9 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| A | 125 MG/L | 5| 7| 7| 7| 8| 8| 8| 9| 9| 9| 5| 6| 6| 7| 7| 7| 9| 9| 9| 0| 6| 6| 7| 7| 8| L | | 9| 2| 3| 4| 1| 2| 7| 0| 3| 5| 6| 7| 8| 5| 6| 7| 6| 7| 8| 0| 0| 1| 0| 9| 6| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Subcutaneous Tissue, Fibroma, | | | Multiple | | 1 | Subcutaneous Tissue, Fibrosarcoma | X | 2 | Subcutaneous Tissue, Histiocytic | | | Sarcoma | X | 1 | Subcutaneous Tissue, Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Periosteum, Cranium, Fibrosarcoma, | | | Metastatic, Skin | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glioma Malignant | | 1 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 1 | Alveolar/Bronchiolar Carcinoma | X | 2 | Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 0| 0| A | 125 MG/L | 5| 7| 7| 7| 8| 8| 8| 9| 9| 9| 5| 6| 6| 7| 7| 7| 9| 9| 9| 0| 6| 6| 7| 7| 8| L | | 9| 2| 3| 4| 1| 2| 7| 0| 3| 5| 6| 7| 8| 5| 6| 7| 6| 7| 8| 0| 0| 1| 0| 9| 6| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Retrobulbar, Fibrosarcoma, | | | Metastatic, Skin | | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lacrimal Gland | | 1 | |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Lipoma | X | 1 | Renal Tubule, Adenoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Leukemia Mononuclear | X X X X X X X | 21 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 7| 6| 6| 7| 0| 0| 2| 4| 6| 6| 7| 7| 9| 9| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| | 9| 5| 1| 6| 6| 5| 7| 6| 7| 0| 7| 3| 5| 5| 8| 3| 3| 4| 1| 9| 9| 9| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000MG/L | 0| 4| 0| 1| 3| 4| 2| 4| 0| 0| 1| 1| 3| 1| 0| 1| 3| 0| 0| 2| 2| 2| 2| 2| 4| | 6| 5| 7| 2| 6| 4| 5| 8| 4| 2| 5| 9| 4| 7| 8| 6| 0| 3| 1| 2| 3| 4| 8| 9| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + A + A A + A A + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + A A + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A A + A + A A + + + A + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + A + + + + A A + + + + + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + A A A + + A A A + + A + + A + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + A A A A + A A + + + A + + A + + + + + + + + + +| |__________________________________________________________________________| Liver | + A + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Mesentery | + + + + + + + + + + + | |__________________________________________________________________________| Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Adenoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + A + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | + | Sarcoma | X | |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + | __________________________________________|__________________________________________________________________________| Page 63 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 7| 6| 6| 7| 0| 0| 2| 4| 6| 6| 7| 7| 9| 9| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| | 9| 5| 1| 6| 6| 5| 7| 6| 7| 0| 7| 3| 5| 5| 8| 3| 3| 4| 1| 9| 9| 9| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000MG/L | 0| 4| 0| 1| 3| 4| 2| 4| 0| 0| 1| 1| 3| 1| 0| 1| 3| 0| 0| 2| 2| 2| 2| 2| 4| | 6| 5| 7| 2| 6| 4| 5| 8| 4| 2| 5| 9| 4| 7| 8| 6| 0| 3| 1| 2| 3| 4| 8| 9| 3| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Schwannoma Benign | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X | |__________________________________________________________________________| Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X| |__________________________________________________________________________| Thyroid Gland | + A A A + + A A + + + A + + A + + + + + + + + + +| Bilateral, C-Cell, Adenoma, Multiple | | C-Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + | |__________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | __________________________________________|__________________________________________________________________________| Page 64 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 7| 6| 6| 7| 0| 0| 2| 4| 6| 6| 7| 7| 9| 9| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| | 9| 5| 1| 6| 6| 5| 7| 6| 7| 0| 7| 3| 5| 5| 8| 3| 3| 4| 1| 9| 9| 9| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000MG/L | 0| 4| 0| 1| 3| 4| 2| 4| 0| 0| 1| 1| 3| 1| 0| 1| 3| 0| 0| 2| 2| 2| 2| 2| 4| | 6| 5| 7| 2| 6| 4| 5| 8| 4| 2| 5| 9| 4| 7| 8| 6| 0| 3| 1| 2| 3| 4| 8| 9| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Carcinoma | X X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, | | Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma, Multiple | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | M M M M + M M M M + M M M M + M M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + I + + + + + + + + + + + + + + +| Thymoma Benign | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + M + + + + M + + + + + + + + + + +| Carcinoma | | Fibroadenoma | X X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | | Subcutaneous Tissue, Fibroma | X X | Subcutaneous Tissue, Fibroma, | | __________________________________________|__________________________________________________________________________| Page 65 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 7| 6| 6| 7| 0| 0| 2| 4| 6| 6| 7| 7| 9| 9| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| | 9| 5| 1| 6| 6| 5| 7| 6| 7| 0| 7| 3| 5| 5| 8| 3| 3| 4| 1| 9| 9| 9| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000MG/L | 0| 4| 0| 1| 3| 4| 2| 4| 0| 0| 1| 1| 3| 1| 0| 1| 3| 0| 0| 2| 2| 2| 2| 2| 4| | 6| 5| 7| 2| 6| 4| 5| 8| 4| 2| 5| 9| 4| 7| 8| 6| 0| 3| 1| 2| 3| 4| 8| 9| 3| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Multiple | X | Subcutaneous Tissue, Sarcoma | X | Subcutaneous Tissue, Schwannoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + + + | |__________________________________________________________________________| Spinal Cord | + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | |__________________________________________________________________________| Nose | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + M + A + + A A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + A + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lacrimal Gland | + | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 66 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 2| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 0| 7| 6| 6| 7| 0| 0| 2| 4| 6| 6| 7| 7| 9| 9| 0| 0| 1| 2| 2| 2| 2| 2| 2| 2| | 9| 5| 1| 6| 6| 5| 7| 6| 7| 0| 7| 3| 5| 5| 8| 3| 3| 4| 1| 9| 9| 9| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1000MG/L | 0| 4| 0| 1| 3| 4| 2| 4| 0| 0| 1| 1| 3| 1| 0| 1| 3| 0| 0| 2| 2| 2| 2| 2| 4| | 6| 5| 7| 2| 6| 4| 5| 8| 4| 2| 5| 9| 4| 7| 8| 6| 0| 3| 1| 2| 3| 4| 8| 9| 3| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +| Mesenchymal Tumor Benign | X | |__________________________________________________________________________| Urinary Bladder | + A + + + + A A + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | Mesothelioma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000MG/L | 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 5| 0| 0| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| L | | 3| 4| 1| 2| 3| 5| 0| 1| 2| 9| 0| 5| 9| 0| 1| 8| 0| 1| 6| 7| 7| 8| 9| 6| 7| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 42 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + | 19 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Adenoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosarcoma | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Tongue | | 1 | Sarcoma | | 1 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 68 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000MG/L | 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 5| 0| 0| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| L | | 3| 4| 1| 2| 3| 5| 0| 1| 2| 9| 0| 5| 9| 0| 1| 8| 0| 1| 6| 7| 7| 8| 9| 6| 7| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 2 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Schwannoma Benign | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X | 3 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X X | 3 | |__________________________________________________________________________|____________| Parathyroid Gland | M + + + M + M + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X X X | 20 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 43 | Bilateral, C-Cell, Adenoma, Multiple | X | 1 | C-Cell, Adenoma | X X | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | | 1 | |__________________________________________________________________________|____________| Tissue NOS | + | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000MG/L | 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 5| 0| 0| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| L | | 3| 4| 1| 2| 3| 5| 0| 1| 2| 9| 0| 5| 9| 0| 1| 8| 0| 1| 6| 7| 7| 8| 9| 6| 7| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 5 | Carcinoma | | 2 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, | | | Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X| 42 | Interstitial Cell, Adenoma, Multiple | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + | 26 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 3 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + I + + + + +| 49 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Thymoma Benign | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 70 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000MG/L | 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 5| 0| 0| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| L | | 3| 4| 1| 2| 3| 5| 0| 1| 2| 9| 0| 5| 9| 0| 1| 8| 0| 1| 6| 7| 7| 8| 9| 6| 7| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 | Carcinoma | X | 1 | Fibroadenoma | X X | 4 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | X | 1 | Subcutaneous Tissue, Fibroma | X X | 4 | Subcutaneous Tissue, Fibroma, | | | Multiple | | 1 | Subcutaneous Tissue, Sarcoma | | 1 | Subcutaneous Tissue, Schwannoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Peripheral Nerve | | 4 | |__________________________________________________________________________|____________| Spinal Cord | + | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 71 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 1000MG/L | 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| 5| 0| 0| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| L | | 3| 4| 1| 2| 3| 5| 0| 1| 2| 9| 0| 5| 9| 0| 1| 8| 0| 1| 6| 7| 7| 8| 9| 6| 7| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lacrimal Gland | | 1 | |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mesenchymal Tumor Benign | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 16 | Mesothelioma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 72 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 6| 8| 4| 6| 9| 3| 4| 5| 5| 7| 7| 7| 8| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| | 3| 5| 2| 5| 2| 0| 9| 4| 1| 1| 1| 2| 8| 1| 9| 9| 1| 3| 3| 0| 8| 0| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2000MG/L | 9| 8| 5| 8| 6| 6| 5| 5| 5| 6| 7| 9| 7| 6| 5| 8| 5| 5| 7| 8| 7| 7| 6| 6| 6| | 2| 4| 7| 7| 7| 9| 5| 4| 9| 1| 3| 9| 1| 5| 8| 6| 1| 2| 6| 5| 8| 4| 0| 2| 3| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + A + A + + + + + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + A + + + + + + + + + + + + + A + + +| |__________________________________________________________________________| Intestine Small, Jejunum | A + A + A + + A + + + + A + + + + + + + + A + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + A + + + + A + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Zymbal's Gland| X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | __________________________________________|__________________________________________________________________________| Page 73 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 6| 8| 4| 6| 9| 3| 4| 5| 5| 7| 7| 7| 8| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| | 3| 5| 2| 5| 2| 0| 9| 4| 1| 1| 1| 2| 8| 1| 9| 9| 1| 3| 3| 0| 8| 0| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2000MG/L | 9| 8| 5| 8| 6| 6| 5| 5| 5| 6| 7| 9| 7| 6| 5| 8| 5| 5| 7| 8| 7| 7| 6| 6| 6| | 2| 4| 7| 7| 7| 9| 5| 4| 9| 1| 3| 9| 1| 5| 8| 6| 1| 2| 6| 5| 8| 4| 0| 2| 3| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | Pheochromocytoma Benign | X X | Bilateral, Ganglioneuroma | X | Bilateral, Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X| Pars Intermedia, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + A + A + + + + + + + + + + + + + + + + A + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + + + + + | Thoracic, Fibroma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 74 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 6| 8| 4| 6| 9| 3| 4| 5| 5| 7| 7| 7| 8| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| | 3| 5| 2| 5| 2| 0| 9| 4| 1| 1| 1| 2| 8| 1| 9| 9| 1| 3| 3| 0| 8| 0| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2000MG/L | 9| 8| 5| 8| 6| 6| 5| 5| 5| 6| 7| 9| 7| 6| 5| 8| 5| 5| 7| 8| 7| 7| 6| 6| 6| | 2| 4| 7| 7| 7| 9| 5| 4| 9| 1| 3| 9| 1| 5| 8| 6| 1| 2| 6| 5| 8| 4| 0| 2| 3| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Adenoma | X X | Carcinoma | X | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Interstitial Cell, Adenoma| | Bilateral, Interstitial Cell, | | Adenoma, Multiple | X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X | Interstitial Cell, Adenoma, Multiple | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + | |__________________________________________________________________________| Lymph Node, Mandibular | M M + M M M M M + M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + I + + + + + + + + + + + + + + + + M + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + M + + + + M + M M + + M + + + + + +| Fibroadenoma | X | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | | Keratoacanthoma | X | __________________________________________|__________________________________________________________________________| Page 75 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 6| 8| 4| 6| 9| 3| 4| 5| 5| 7| 7| 7| 8| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| | 3| 5| 2| 5| 2| 0| 9| 4| 1| 1| 1| 2| 8| 1| 9| 9| 1| 3| 3| 0| 8| 0| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2000MG/L | 9| 8| 5| 8| 6| 6| 5| 5| 5| 6| 7| 9| 7| 6| 5| 8| 5| 5| 7| 8| 7| 7| 6| 6| 6| | 2| 4| 7| 7| 7| 9| 5| 4| 9| 1| 3| 9| 1| 5| 8| 6| 1| 2| 6| 5| 8| 4| 0| 2| 3| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Fibroma | X X X | Subcutaneous Tissue, Fibroma, | | Multiple | | Subcutaneous Tissue, Osteosarcoma | X| Subcutaneous Tissue, Schwannoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Zymbal's Gland| X | |__________________________________________________________________________| Peripheral Nerve | + + + | |__________________________________________________________________________| Spinal Cord | + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Zymbal's Gland| X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 76 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 _____________________________________________________________________________________________________________________ | 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 6| 8| 4| 6| 9| 3| 4| 5| 5| 7| 7| 7| 8| 9| 9| 0| 0| 0| 1| 1| 2| 2| 2| 2| | 3| 5| 2| 5| 2| 0| 9| 4| 1| 1| 1| 2| 8| 1| 9| 9| 1| 3| 3| 0| 8| 0| 9| 9| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2000MG/L | 9| 8| 5| 8| 6| 6| 5| 5| 5| 6| 7| 9| 7| 6| 5| 8| 5| 5| 7| 8| 7| 7| 6| 6| 6| | 2| 4| 7| 7| 7| 9| 5| 4| 9| 1| 3| 9| 1| 5| 8| 6| 1| 2| 6| 5| 8| 4| 0| 2| 3| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Lacrimal Gland | +| |__________________________________________________________________________| Zymbal's Gland | + + + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| Lipoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X X| Mesothelioma Malignant | | __________________________________________|__________________________________________________________________________| Page 77 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 2000MG/L | 6| 7| 8| 8| 8| 9| 9| 9| 9| 9| 7| 7| 8| 8| 8| 5| 5| 6| 6| 7| 7| 9| 9| 9| 0| L | | 4| 2| 1| 2| 3| 0| 1| 6| 7| 8| 0| 9| 0| 8| 9| 3| 6| 6| 8| 5| 7| 3| 4| 5| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + | 23 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 78 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 2000MG/L | 6| 7| 8| 8| 8| 9| 9| 9| 9| 9| 7| 7| 8| 8| 8| 5| 5| 6| 6| 7| 7| 9| 9| 9| 0| L | | 4| 2| 1| 2| 3| 0| 1| 6| 7| 8| 0| 9| 0| 8| 9| 3| 6| 6| 8| 5| 7| 3| 4| 5| 0| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | | | | Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Malignant | X | 1 | Pheochromocytoma Benign | X X X | 5 | Bilateral, Ganglioneuroma | | 1 | Bilateral, Pheochromocytoma Benign | X X | 3 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X X | 5 | Carcinoma | X | 2 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X | 15 | Pars Intermedia, Adenoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | C-Cell, Adenoma | X X X X X X X X| 9 | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | X X | 2 | Follicular Cell, Carcinoma | X X X| 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 79 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 2000MG/L | 6| 7| 8| 8| 8| 9| 9| 9| 9| 9| 7| 7| 8| 8| 8| 5| 5| 6| 6| 7| 7| 9| 9| 9| 0| L | | 4| 2| 1| 2| 3| 0| 1| 6| 7| 8| 0| 9| 0| 8| 9| 3| 6| 6| 8| 5| 7| 3| 4| 5| 0| | _____________________________________________________________________________________________________________________|____________| GENERAL BODY SYSTEM - cont | | | | | | Tissue NOS | + + | 7 | Thoracic, Fibroma | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X| 5 | Carcinoma | X| 2 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Interstitial Cell, Adenoma| X | 1 | Bilateral, Interstitial Cell, | | | Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X| 39 | Interstitial Cell, Adenoma | | 2 | Interstitial Cell, Adenoma, Multiple | X | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + +| 34 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M M M M M M M M + M M M M M M M M M + M M M M M M| 4 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 80 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 2000MG/L | 6| 7| 8| 8| 8| 9| 9| 9| 9| 9| 7| 7| 8| 8| 8| 5| 5| 6| 6| 7| 7| 9| 9| 9| 0| L | | 4| 2| 1| 2| 3| 0| 1| 6| 7| 8| 0| 9| 0| 8| 9| 3| 6| 6| 8| 5| 7| 3| 4| 5| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 44 | Fibroadenoma | X X X | 4 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Carcinoma | X X | 2 | Keratoacanthoma | | 1 | Subcutaneous Tissue, Fibroma | X X X X | 7 | Subcutaneous Tissue, Fibroma, | | | Multiple | X | 1 | Subcutaneous Tissue, Osteosarcoma | | 1 | Subcutaneous Tissue, Schwannoma | | | Malignant | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | |__________________________________________________________________________|____________| Peripheral Nerve | | 3 | |__________________________________________________________________________|____________| Spinal Cord | + + | 5 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 81 NTP Experiment-Test: 96010-03 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17 Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03 Route: DOSED WATER Time: 13:33:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 2000MG/L | 6| 7| 8| 8| 8| 9| 9| 9| 9| 9| 7| 7| 8| 8| 8| 5| 5| 6| 6| 7| 7| 9| 9| 9| 0| L | | 4| 2| 1| 2| 3| 0| 1| 6| 7| 8| 0| 9| 0| 8| 9| 3| 6| 6| 8| 5| 7| 3| 4| 5| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma | X | 1 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lacrimal Gland | | 1 | |__________________________________________________________________________|____________| Zymbal's Gland | | 3 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lipoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 23 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 640838-640838/640838 --multipart-boundary--