TDMS Study 96010-03 Pathology Tables
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
FINAL#1/RATS
Facility: Southern Research Institute
Chemical CAS #: 7775-09-9
Lock Date: 10/16/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 3 3 6 5
Moribund Sacrifice 10 11 11 4
Survivors
Terminal Sacrifice 37 34 32 40
Natural Death 1 1
Moribund Sacrifice 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (50) (49) (45) (49)
Amyloid Deposition 1 [2.0]
Epithelium, Cyst 1 [1.0]
Liver (50) (50) (50) (50)
Angiectasis, Focal 2 [2.0]
Basophilic Focus 42 44 41 42
Cholangiofibrosis 1 [4.0] 1 [4.0] 3 [4.0]
Clear Cell Focus 6 16 18 10
Congestion 6 [2.0] 2 [3.0] 2 [2.5] 1 [2.0]
Degeneration, Cystic, Focal 1 [2.0] 1 [2.0] 3 [2.0]
Eosinophilic Focus 1 1 2
Fibrosis, Focal 1 [1.0]
Hemorrhage 1 [2.0]
Hepatodiaphragmatic Nodule 7 4 8 3
Hyperplasia, Focal, Histiocytic 20 [1.6] 19 [1.7] 16 [1.6] 23 [1.8]
Hyperplasia, Focal, Regenerative 1 [1.0] 1 [3.0]
Hyperplasia, Regenerative 2 [4.0]
Infarct, Multiple 1 [3.0]
Infiltration Cellular, Focal,
Polymorphonuclear 1 [2.0]
Infiltration Cellular, Polymorphonuclear 1 [3.0]
Infiltration Cellular, Mixed Cell 39 [1.9] 38 [1.9] 35 [1.9] 41 [2.0]
Mixed Cell Focus 12 6 7 8
Thrombosis 1 [3.0]
Bile Duct, Cyst 1 [2.0]
Bile Duct, Hyperplasia 29 [1.5] 24 [1.5] 34 [1.7] 26 [2.0]
Capsule, Cyst 1 [3.0]
Hepatocyte, Karyomegaly 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Necrosis, Focal 2 [1.5] 1 [2.0]
Hepatocyte, Vacuolization Cytoplasmic 2 [2.0]
Hepatocyte, Vacuolization Cytoplasmic,
Diffuse 1 [2.0] 2 [2.5] 1 [2.0] 2 [3.0]
Hepatocyte, Vacuolization Cytoplasmic, Focal 17 [1.5] 10 [1.7] 10 [1.8] 10 [1.4]
Hepatocyte, Periportal, Vacuolization
Cytoplasmic 2 [2.0]
Hepatocyte, Periportal, Centrilobular,
Vacuolization Cytoplasmic 1 [2.0]
Hepatocyte, Centrilobular, Necrosis 2 [2.0] 1 [4.0] 1 [3.0] 2 [2.5]
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 5 [3.0] 3 [3.0] 8 [3.4] 3 [2.3]
Hepatocyte, Midzonal, Vacuolization
Cytoplasmic 2 [3.5]
Mesentery (18) (10) (13) (16)
Inflammation, Chronic, Focal 1 [2.0]
Fat, Necrosis 4 [2.5] 2 [2.0] 1 [3.0]
Fat, Necrosis, Focal 12 [2.3] 5 [2.6] 9 [2.8] 13 [2.6]
Pancreas (50) (49) (49) (49)
Lipomatosis 1 [1.0]
Acinus, Atrophy, Diffuse 1 [4.0]
Acinus, Atrophy, Focal 15 [1.4] 8 [2.1] 9 [1.6] 16 [1.4]
Duct, Cyst, Focal 1 [1.0] 2 [1.0] 4 [1.0] 1 [2.0]
Duct, Cyst, Focal, Multiple 10 [1.4] 14 [1.8] 11 [1.5] 18 [1.6]
Duct, Hyperplasia, Focal 1 [1.0]
Salivary Glands (50) (50) (50) (50)
Atrophy, Focal 2 [2.0]
Stomach, Forestomach (50) (50) (50) (50)
Edema 1 [3.0] 1 [3.0] 1 [2.0]
Erosion 1 [2.0]
Inflammation, Chronic 2 [2.5] 1 [3.0]
Inflammation, Chronic, Focal 1 [2.0]
Perforation 1 [3.0]
Ulcer 2 [2.0] 7 [2.4] 1 [2.0]
Epithelium, Hyperplasia 2 [2.0] 4 [2.3] 6 [2.5] 1 [2.0]
Stomach, Glandular (50) (49) (49) (50)
Erosion 2 [2.0] 2 [1.5] 2 [1.5]
Erosion, Focal 1 [2.0]
Inflammation, Chronic 1 [2.0]
Necrosis, Focal 1 [2.0]
Pigmentation, Focal 1 [2.0]
Ulcer 1 [2.0]
Tooth (2) (2) (1)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Malformation 1
Dentine, Malformation 1 [3.0]
Peridontal Tissue, Inflammation, Chronic 1 [3.0] 2 [3.0]
Peridontal Tissue, Inflammation, Chronic,
Focal 1 [3.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Thrombosis 1 [3.0]
Heart (50) (50) (50) (50)
Cardiomyopathy 4 [1.5] 2 [2.5] 2 [2.0]
Infiltration Cellular, Mixed Cell 1 [1.0] 1 [2.0] 4 [1.5]
Thrombosis 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 2 [1.0] 3 [1.3] 5 [1.0] 2 [1.0]
Angiectasis 2 [2.5] 1 [3.0] 1 [2.0] 2 [3.0]
Cytoplasmic Alteration, Focal 1 [2.0] 2 [2.0] 3 [2.0] 2 [1.5]
Degeneration, Cystic, Focal 1 [3.0] 1 [2.0]
Fibrosis, Focal 1 [2.0]
Hematopoietic Cell Proliferation 1 [2.0]
Hemorrhage 1 [3.0] 1 [3.0] 2 [2.5]
Infiltration Cellular, Mixed Cell 1 [2.0]
Necrosis, Focal 1 [3.0]
Vacuolization Cytoplasmic, Focal 7 [1.4] 13 [1.6] 7 [1.9] 8 [1.8]
Adrenal Medulla (50) (50) (50) (50)
Angiectasis 1 [3.0]
Hyperplasia, Focal 3 [1.0] 4 [1.3] 1 [1.0] 1 [1.0]
Infiltration Cellular, Focal, Lymphoid 1 [2.0]
Islets, Pancreatic (50) (49) (49) (50)
Hyperplasia, Focal 1 [2.0]
Parathyroid Gland (47) (47) (48) (47)
Hyperplasia, Focal 1 [3.0]
Pituitary Gland (49) (49) (50) (50)
Angiectasis 10 [2.5] 6 [2.8] 2 [3.5] 13 [2.6]
Pigmentation, Focal 1 [2.0]
Pars Distalis, Angiectasis 1 [3.0] 2 [2.5] 2 [3.5]
Pars Distalis, Cyst 2 [2.5] 2 [2.5] 1 [3.0] 2 [1.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cytoplasmic Alteration, Focal 3 [1.0] 1 [1.0] 2 [1.0] 3 [1.7]
Pars Distalis, Degeneration, Cystic, Focal 11 [1.9] 14 [1.8] 11 [2.4] 3 [2.0]
Pars Distalis, Hemorrhage, Focal 9 [2.9] 6 [2.8] 10 [2.5] 2 [3.0]
Pars Distalis, Hyperplasia, Focal 7 [2.3] 5 [2.4] 10 [2.8] 4 [1.8]
Pars Distalis, Infiltration Cellular, Focal 1 [2.0]
Pars Nervosa, Hyperplasia, Atypical, Focal 1 [3.0]
Rathke's Cleft, Cyst 1 [2.0] 2 [2.5]
Rathke's Cleft, Hemorrhage 1 [2.0] 2 [2.5] 2 [2.5] 6 [2.8]
Rathke's Cleft, Hyperplasia, Cystic 1 [3.0]
Thyroid Gland (47) (47) (43) (46)
Congestion 1 [1.0]
Ultimobranchial Cyst 1 [2.0] 1 [1.0]
C-Cell, Hyperplasia 43 [2.2] 45 [2.1] 43 [2.5] 44 [2.3]
Follicle, Mineralization, Focal 25 [1.0] 26 [1.0] 40 [1.3] 44 [2.1]
Follicular Cell, Hyperplasia, Cystic, Focal 1 [2.0]
Follicular Cell, Hypertrophy 3 [1.3] 7 [1.0] 27 [1.2] 42 [1.8]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2) (4) (6)
Mediastinum, Cyst 1 [3.0]
Mediastinum, Thrombosis 1 [3.0]
Oral, Foreign Body, Focal 1 [3.0]
Oral, Necrosis, Focal 1 [3.0]
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (50) (49)
Cyst 1 [4.0]
Degeneration, Cystic 5 [3.0] 2 [3.0] 6 [2.8] 1 [3.0]
Hyperplasia 1 [3.0]
Hyperplasia, Cystic 1 [3.0] 4 [2.5] 3 [2.3] 1 [3.0]
Hyperplasia, Cystic, Focal 1 [2.0]
Inflammation, Chronic 6 [2.8] 2 [1.5] 1 [3.0] 3 [2.3]
Duct, Inflammation, Chronic 1 [4.0]
Ovary (50) (50) (49) (50)
Cyst 5 [2.2] 1 [3.0] 1 [3.0] 4 [1.8]
Corpus Luteum, Hyperplasia 1 [3.0]
Interstitial Cell, Hyperplasia 1 [2.0] 1 [3.0]
Periovarian Tissue, Cyst 4 [3.0] 4 [3.0] 2 [3.5] 1 [3.0]
Uterus (50) (50) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hemorrhage 1 [3.0] 1 [3.0]
Hydrometra 1 [3.0]
Inflammation, Chronic 1 [3.0]
Inflammation, Focal, Suppurative 1 [3.0]
Inflammation, Suppurative 1 [3.0] 1 [3.0]
Ulcer, Chronic Active 1 [4.0]
Endometrium, Hyperplasia, Cystic 16 [1.8] 7 [1.4] 16 [1.9] 11 [1.8]
Vagina (6) (3) (3) (1)
Cyst 2 [3.0] 1 [3.0] 1 [3.0] 1 [3.0]
Inflammation, Chronic 1 [3.0]
Inflammation, Suppurative 1 [3.0] 1 [3.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (50)
Angiectasis 1 [3.0]
Hemorrhage 1 [2.0]
Hyperplasia 2 [3.5] 1 [1.0] 1 [2.0]
Hyperplasia, Focal, Histiocytic 2 [3.0] 2 [4.0]
Myeloid Cell, Hyperplasia 7 [2.4] 3 [2.7] 2 [2.5] 6 [2.7]
Myeloid Cell, Erythroid Cell, Hyperplasia 2 [3.0] 2 [3.0] 3 [3.0]
Lymph Node (36) (34) (30) (39)
Hyperplasia, Plasma Cell 1 [3.0]
Pigmentation 1 [3.0]
Deep Cervical, Hemorrhage 1 [2.0]
Deep Cervical, Hyperplasia, Lymphoid 1 [3.0]
Deep Cervical, Hyperplasia, Plasma Cell 1 [3.0]
Mediastinal, Angiectasis 1 [3.0]
Mediastinal, Congestion 1 [3.0]
Mediastinal, Ectasia 2 [3.0] 4 [3.0] 2 [3.0] 4 [3.0]
Mediastinal, Hemorrhage 6 [3.0] 6 [3.0] 5 [3.0] 3 [2.7]
Mediastinal, Hyperplasia, Histiocytic 1 [3.0] 4 [3.0] 2 [3.0] 3 [3.0]
Mediastinal, Hyperplasia, Lymphoid 1 [3.0] 2 [2.5] 2 [3.0] 3 [3.0]
Mediastinal, Hyperplasia, Plasma Cell 1 [3.0]
Mediastinal, Infiltration Cellular, Mixed
Cell 1 [3.0]
Mediastinal, Pigmentation 1 [3.0]
Pancreatic, Angiectasis 1 [3.0]
Pancreatic, Ectasia 1 [2.0] 1 [3.0]
Pancreatic, Hemorrhage 5 [3.0] 3 [3.0] 5 [2.6]
Pancreatic, Hyperplasia, Histiocytic 31 [1.8] 22 [2.2] 15 [2.5] 25 [2.4]
Pancreatic, Hyperplasia, Lymphoid 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pancreatic, Pigmentation 1 [2.0] 7 [1.6] 3 [2.0] 6 [1.7]
Lymph Node, Mandibular (4) (6) (4) (5)
Ectasia 1 [3.0]
Lymph Node, Mesenteric (50) (49) (49) (50)
Hemorrhage 1 [3.0]
Hyperplasia, Focal, Histiocytic 1 [3.0]
Hyperplasia, Histiocytic 2 [3.0] 4 [3.0] 4 [3.3]
Hyperplasia, Lymphoid 1 [3.0]
Spleen (50) (50) (50) (50)
Angiectasis, Focal 1 [3.0] 1 [3.0]
Fibrosis, Focal 1 [3.0] 1 [3.0]
Hematopoietic Cell Proliferation 16 [2.4] 21 [2.4] 8 [2.4] 17 [2.4]
Hemorrhage 1 [2.0] 1 [2.0] 1 [3.0] 2 [2.5]
Hyperplasia, Focal, Histiocytic 2 [4.0] 4 [2.8] 2 [3.5] 5 [3.6]
Infarct 1 [3.0]
Pigmentation, Focal 1 [3.0]
Red Pulp, Fibrosis, Diffuse 1 [3.0]
Thymus (49) (48) (48) (48)
Angiectasis 2 [2.5] 1 [2.0]
Cyst 1 [2.0]
Hemorrhage 1 [3.0] 2 [2.0] 1 [3.0]
Hyperplasia, Lymphoid 1 [2.0] 1 [3.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Dilatation 37 [3.1] 39 [3.1] 34 [3.0] 38 [3.1]
Ectasia 4 [2.8] 1 [2.0] 3 [2.7] 2 [2.5]
Fibrosis 2 [2.5] 1 [3.0] 1 [2.0] 4 [2.8]
Fibrosis, Focal 1 [2.0]
Hyperplasia 7 [2.4] 11 [2.2] 10 [2.4] 9 [2.3]
Hyperplasia, Focal 1 [3.0] 1 [4.0]
Inflammation, Chronic 1 [2.0]
Skin (50) (50) (50) (50)
Inflammation, Chronic, Focal 1 [1.0]
Ulcer 1 [1.0]
Subcutaneous Tissue, Fibrosis, Focal 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Compression, Focal 9 [2.7] 9 [2.9] 10 [2.9] 9 [3.0]
Hemorrhage, Focal 4 [2.3] 3 [1.7] 2 [1.5]
Necrosis, Focal 1 [3.0]
Thalamus, Mineralization, Focal 1 [3.0]
Thalamus, Necrosis, Focal 1 [3.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 2 [3.0] 1 [3.0]
Hemorrhage, Focal 1 [2.0] 1 [3.0] 2 [3.0]
Hyperplasia, Focal, Histiocytic 1 [2.0] 1 [2.0] 2 [3.0]
Hyperplasia, Histiocytic 4 [1.8] 6 [1.3] 5 [1.6] 2 [1.0]
Infiltration Cellular, Polymorphonuclear 1 [3.0]
Infiltration Cellular, Mixed Cell 2 [2.5] 3 [2.0] 2 [2.0] 1 [3.0]
Inflammation, Chronic, Focal 2 [1.0] 4 [1.5] 2 [1.0]
Metaplasia, Focal, Osseous 1 [2.0]
Alveolar Epithelium, Hyperplasia 1 [1.0]
Alveolar Epithelium, Hyperplasia, Focal 4 [1.5] 2 [1.5] 3 [2.0] 2 [1.5]
Interstitium, Edema 1 [3.0]
Mediastinum, Edema 1 [3.0]
Peribronchiolar, Hyperplasia, Lymphoid 1 [2.0]
Nose (50) (50) (50) (50)
Inflammation, Suppurative 1 [2.0] 2 [2.0]
Nasolacrimal Duct, Inflammation 1 [2.0] 1 [3.0]
Respiratory Epithelium, Metaplasia, Focal,
Squamous 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (49) (47) (50)
Atrophy 1 [3.0]
Cataract 2 [2.5] 3 [2.3] 1 [3.0] 2 [3.0]
Hemorrhage 1 [3.0]
Retinal Detachment 1 [3.0]
Bilateral, Atrophy 1 [4.0]
Cornea, Inflammation, Chronic 1 [4.0] 1 [3.0]
Cornea, Necrosis, Focal 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Retina, Degeneration 1 [4.0] 2 [3.0] 1 [3.0] 2 [2.5]
Harderian Gland (50) (50) (50) (50)
Hyperplasia, Cystic, Focal 1 [2.0]
Hyperplasia, Focal 1 [1.0]
Hyperplasia, Focal, Histiocytic 2 [2.5] 1 [1.0]
Inflammation, Chronic, Focal 1 [3.0] 1 [1.0] 2 [1.0]
Metaplasia, Focal, Squamous 1 [3.0]
Epithelium, Hyperplasia, Focal 1 [1.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (47) (47)
Atrophy, Diffuse 1 [4.0]
Atrophy, Focal 1 [3.0] 2 [3.0]
Cyst 1 [2.0] 1 [2.0]
Hyperplasia, Lymphoid 1 [2.0]
Infarct 1 [3.0] 1 [3.0]
Infiltration Cellular, Polymorphonuclear 1 [3.0]
Inflammation, Chronic 1 [2.0] 2 [2.0]
Inflammation, Chronic, Focal, Granulomatous 1 [3.0]
Nephropathy 43 [1.1] 41 [1.2] 37 [1.1] 38 [1.3]
Pelvis, Inflammation, Chronic 1 [3.0]
Pelvis, Transitional Epithelium, Hyperplasia 1 [2.0]
Renal Tubule, Accumulation, Hyaline Droplet 5 [2.6] 12 [2.0] 11 [2.2] 5 [2.0]
Renal Tubule, Pigmentation 2 [1.0] 1 [2.0] 4 [1.8] 4 [2.3]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 10 13 11 14
Natural Death 3 10 8 8
Accidently Killed 1
Survivors
Terminal Sacrifice 36 27 31 28
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (47) (44) (49)
Edema 2 [3.0]
Intestine Large, Rectum (48) (47) (47) (50)
Congestion 1 [3.0]
Edema 1 [3.0]
Hemorrhage 1 [3.0]
Intestine Large, Cecum (47) (46) (43) (47)
Edema 1 [3.0] 1 [3.0]
Ulcer 1 [4.0]
Intestine Small, Duodenum (49) (46) (46) (47)
Ulcer 1 [3.0]
Epithelium, Hyperplasia 1 [3.0]
Intestine Small, Jejunum (47) (46) (42) (44)
Epithelium, Necrosis 1 [2.0]
Intestine Small, Ileum (47) (46) (42) (47)
Ulcer 1 [4.0]
Liver (50) (50) (48) (50)
Angiectasis, Focal 2 [1.5] 1 [2.0] 1 [2.0] 3 [2.0]
Basophilic Focus 27 30 33 29
Cholangiofibrosis 2 [3.0] 1 [1.0] 1 [4.0] 1 [2.0]
Clear Cell Focus 21 18 29 15
Congestion 2 [3.0]
Degeneration, Cystic, Focal 13 [1.4] 9 [1.7] 12 [2.0] 14 [1.9]
Eosinophilic Focus 2 3 2
Fibrosis, Focal 1 [3.0] 1 [2.0]
Hemorrhage, Focal 1 [3.0]
Hepatodiaphragmatic Nodule 6 [2.7] 2 [3.0] 3 [3.0] 5 [3.0]
Hyperplasia, Focal, Histiocytic 6 [1.8] 2 [1.5] 8 [1.5] 5 [1.4]
Hyperplasia, Focal, Lymphoid 1 [3.0] 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infarct 1 [3.0]
Infiltration Cellular, Mixed Cell 36 [2.0] 29 [1.9] 33 [1.9] 28 [2.0]
Mixed Cell Focus 13 11 3 8
Bile Duct, Hyperplasia 48 [2.8] 49 [2.9] 46 [2.8] 50 [2.9]
Centrilobular, Congestion 1 [3.0]
Hepatocyte, Necrosis, Focal 1 [2.0] 2 [2.5]
Hepatocyte, Vacuolization Cytoplasmic,
Diffuse 3 [2.3] 3 [2.7] 4 [3.3]
Hepatocyte, Vacuolization Cytoplasmic, Focal 26 [1.8] 15 [1.7] 14 [1.9] 18 [1.7]
Hepatocyte, Periportal, Necrosis 1 [3.0]
Hepatocyte, Periportal, Vacuolization
Cytoplasmic 1 [2.0] 1 [2.0]
Hepatocyte, Centrilobular, Atrophy 1 [3.0]
Hepatocyte, Centrilobular, Necrosis 1 [4.0] 3 [2.0] 6 [2.5] 4 [2.5]
Hepatocyte, Centrilobular, Vacuolization
Cytoplasmic 4 [2.8] 9 [3.0] 12 [2.9] 11 [2.6]
Hepatocyte, Midzonal, Necrosis 1 [3.0]
Hepatocyte, Midzonal, Vacuolization
Cytoplasmic 6 [2.5] 1 [3.0] 1 [3.0]
Hepatocyte, Midzonal, Vacuolization
Cytoplasmic, Focal 1 [3.0]
Portal, Fibrosis 1 [3.0]
Portal, Hemorrhage 1 [3.0]
Mesentery (19) (20) (19) (23)
Angiectasis 1 [3.0]
Hemorrhage 1 [4.0] 1 [3.0]
Inflammation, Chronic 1 [3.0]
Inflammation, Chronic, Focal 1 [3.0]
Fat, Necrosis 2 [3.0] 2 [3.0] 2 [2.0]
Fat, Necrosis, Focal 12 [2.8] 10 [2.7] 13 [2.5] 14 [2.5]
Pancreas (49) (49) (49) (50)
Inflammation, Chronic 1 [3.0]
Acinus, Atrophy, Diffuse 1 [4.0]
Acinus, Atrophy, Focal 23 [1.8] 23 [2.1] 27 [1.9] 15 [1.7]
Acinus, Hyperplasia, Focal 1 [3.0] 1 [2.0]
Duct, Cyst, Focal 1 [3.0] 1 [3.0]
Duct, Cyst, Focal, Multiple 15 [1.7] 13 [1.6] 18 [1.8] 15 [1.8]
Salivary Glands (49) (50) (50) (50)
Atrophy 1 [3.0]
Hyperplasia, Focal, Histiocytic 1 [3.0]
Stomach, Forestomach (50) (50) (50) (50)
Edema 1 [3.0] 1 [3.0] 4 [3.0]
Erosion 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 4 [2.3] 1 [3.0]
Inflammation, Chronic, Focal 1 [3.0]
Inflammation, Focal 1 [2.0] 1 [3.0]
Ulcer 1 [2.0] 5 [2.4] 2 [1.5] 4 [2.8]
Epithelium, Cyst 1 [2.0]
Epithelium, Hyperplasia 2 [2.0] 8 [2.4] 1 [3.0] 7 [2.3]
Epithelium, Hyperplasia, Focal 1 [3.0]
Stomach, Glandular (49) (48) (48) (50)
Erosion 3 [1.3] 2 [2.0] 4 [1.8] 4 [1.5]
Perforation 1 [3.0]
Pigmentation, Focal 1 [2.0] 1 [1.0]
Ulcer 1 [3.0] 3 [2.7]
Epithelium, Hyperplasia, Focal 1 [2.0]
Tongue (1) (1) (1) (1)
Epithelium, Hyperplasia 1 [3.0]
Tooth (1) (1)
Malformation 1 [2.0]
Peridontal Tissue, Hyperplasia, Squamous 1 [3.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 6 [1.5] 3 [2.0] 7 [1.7] 10 [1.8]
Infiltration Cellular, Mixed Cell 2 [1.5] 1 [2.0] 2 [2.0]
Inflammation, Chronic, Focal 1 [3.0]
Thrombosis 1 [3.0] 1 [4.0] 2 [3.0] 2 [3.0]
Artery, Inflammation, Chronic, Focal 1 [2.0]
Endocardium, Valve, Inflammation, Chronic,
Focal 1 [2.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (50) (50)
Accessory Adrenal Cortical Nodule 1 [1.0] 7 [1.0] 4 [1.3] 3 [1.0]
Atrophy 1 [3.0]
Cytoplasmic Alteration, Focal 3 [1.3] 3 [1.7] 2 [1.5] 4 [1.8]
Degeneration, Cystic, Focal 2 [3.0]
Hyperplasia, Diffuse 1 [3.0]
Infiltration Cellular, Mixed Cell 1 [2.0]
Necrosis, Focal 1 [2.0]
Vacuolization Cytoplasmic, Diffuse 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 12
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Vacuolization Cytoplasmic, Focal 12 [1.5] 8 [1.4] 7 [1.9] 6 [1.5]
Capsule, Fibrosis, Focal 1 [2.0]
Adrenal Medulla (49) (49) (50) (50)
Hyperplasia, Focal 5 [1.6] 12 [1.4] 9 [1.6] 13 [1.8]
Islets, Pancreatic (50) (49) (49) (50)
Hyperplasia 2 [2.0]
Hyperplasia, Focal 1 [2.0] 1 [2.0]
Parathyroid Gland (49) (50) (47) (49)
Hyperplasia, Focal 1 [2.0]
Pituitary Gland (48) (50) (49) (50)
Angiectasis 2 [2.0] 4 [2.5] 1 [2.0] 3 [2.7]
Hemorrhage 1 [4.0]
Hemorrhage, Focal 1 [2.0]
Pars Distalis, Cyst 2 [1.5] 1 [3.0] 1 [2.0] 1 [2.0]
Pars Distalis, Cytoplasmic Alteration, Focal 3 [1.3] 7 [1.4] 3 [1.0] 8 [1.4]
Pars Distalis, Degeneration, Cystic, Focal 2 [1.0] 2 [3.0]
Pars Distalis, Hemorrhage, Focal 2 [3.0] 2 [2.5] 1 [2.0] 3 [2.7]
Pars Distalis, Hyperplasia, Focal 4 [2.3] 2 [3.5] 3 [2.3] 1 [2.0]
Pars Distalis, Pars Nervosa, Hemorrhage,
Focal 1 [3.0]
Pars Intermedia, Hemorrhage, Focal 1 [2.0]
Rathke's Cleft, Cyst 1 [4.0]
Rathke's Cleft, Hemorrhage 1 [3.0] 2 [2.5] 2 [3.0]
Rathke's Cleft, Hyperplasia, Cystic 1 [2.0]
Thyroid Gland (47) (44) (43) (47)
C-Cell, Hyperplasia 45 [1.8] 42 [2.0] 41 [2.0] 44 [1.8]
C-Cell, Hyperplasia, Focal 1 [2.0]
Follicle, Cyst 1 [2.0] 1 [2.0] 2 [3.0]
Follicle, Degeneration, Cystic, Focal 2 [1.5]
Follicle, Mineralization, Focal 45 [1.1] 43 [1.1] 42 [2.0] 42 [2.3]
Follicular Cell, Hypertrophy 4 [1.3] 13 [1.2] 33 [1.5] 40 [2.0]
Follicular Cell, Hypertrophy, Focal 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (5) (6) (2) (7)
Abdominal, Fibrosis 1 [3.0]
Mediastinum, Hemorrhage 1 [3.0]
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 13
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Epididymis (50) (50) (50) (50)
Fibrosis 1 [3.0]
Inflammation, Chronic 1 [2.0] 1 [3.0] 2 [2.5]
Penis (2)
Thrombosis 1 [2.0]
Preputial Gland (48) (49) (50) (50)
Atrophy 1 [3.0]
Cyst 1 [2.0] 1 [2.0]
Degeneration, Cystic 2 [3.0] 1 [3.0] 2 [3.0]
Hyperplasia, Cystic 1 [3.0] 1 [3.0]
Inflammation, Chronic 22 [1.7] 12 [1.8] 18 [1.8] 20 [1.3]
Necrosis 1 [3.0]
Prostate (50) (49) (50) (50)
Inflammation, Chronic 21 [1.9] 23 [2.0] 29 [2.2] 30 [1.8]
Mineralization, Focal 3 [2.0] 2 [2.5] 3 [2.0] 4 [2.3]
Epithelium, Hyperplasia, Focal 11 [1.3] 4 [1.3] 2 [2.0] 11 [1.2]
Testes (50) (50) (50) (50)
Atrophy 4 [3.0] 10 [2.9] 9 [2.9] 6 [3.2]
Bilateral, Atrophy 1 [3.0]
Germinal Epithelium, Atrophy 1 [3.0]
Germinal Epithelium, Degeneration 1 [2.0]
Interstitial Cell, Hyperplasia, Focal 1 [1.0] 1 [2.0] 1 [2.0] 3 [1.7]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (48) (50) (49)
Angiectasis 1 [2.0]
Atrophy 1 [3.0]
Fibrosis 2 [3.0]
Hyperplasia 28 [1.9] 35 [2.3] 41 [2.4] 40 [2.7]
Myeloid Cell, Erythroid Cell, Hyperplasia 2 [2.5]
Lymph Node (34) (24) (26) (34)
Ectasia 1 [4.0]
Hemorrhage 1 [3.0]
Deep Cervical, Hemorrhage 1 [3.0]
Deep Cervical, Hyperplasia, Plasma Cell 1 [3.0]
Mediastinal, Angiectasis 1 [3.0]
Mediastinal, Ectasia 5 [2.6] 7 [3.0] 5 [3.0] 3 [3.3]
Mediastinal, Hemorrhage 3 [3.0] 2 [2.5] 2 [3.0] 1 [3.0]
Mediastinal, Hyperplasia, Histiocytic 3 [3.0] 2 [3.0] 1 [3.0]
Mediastinal, Hyperplasia, Lymphoid 1 [3.0] 1 [3.0] 3 [3.3]
Mediastinal, Hyperplasia, Plasma Cell 1 [3.0] 2 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 14
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Infiltration Cellular,
Polymorphonuclear 1 [3.0]
Mediastinal, Inflammation, Chronic Active 1 [3.0]
Mediastinal, Inflammation, Suppurative 1 [3.0]
Pancreatic, Angiectasis 2 [3.0]
Pancreatic, Ectasia 3 [2.7] 3 [3.0] 3 [3.0] 6 [2.8]
Pancreatic, Hemorrhage 5 [2.8] 3 [3.0] 1 [2.0] 1 [3.0]
Pancreatic, Hyperplasia, Histiocytic 8 [3.0] 5 [3.0] 9 [3.0] 6 [3.0]
Pancreatic, Hyperplasia, Lymphoid 1 [3.0] 1 [3.0]
Pancreatic, Pigmentation 1 [2.0] 1 [2.0] 1 [3.0]
Renal, Hemorrhage 1 [3.0]
Renal, Hyperplasia, Focal, Histiocytic 1 [3.0]
Renal, Hyperplasia, Lymphoid 1 [3.0]
Lymph Node, Mesenteric (49) (50) (49) (50)
Amyloid Deposition 1 [4.0]
Ectasia 1 [3.0] 1 [3.0] 1 [3.0] 3 [3.7]
Hemorrhage 2 [2.5] 3 [3.0]
Hyperplasia, Focal, Histiocytic 1 [2.0]
Hyperplasia, Histiocytic 3 [3.0] 3 [3.0] 1 [3.0]
Hyperplasia, Lymphoid 2 [3.0] 1 [3.0] 1 [3.0]
Spleen (48) (49) (49) (50)
Amyloid Deposition 1 [3.0]
Angiectasis, Focal 2 [3.0] 1 [3.0] 3 [2.3]
Atrophy 1 [2.0]
Congestion 1 [3.0] 1 [3.0]
Fibrosis, Focal 2 [3.0] 2 [3.0] 4 [2.8]
Hematopoietic Cell Proliferation 2 [2.5] 6 [2.3] 4 [2.5] 11 [2.5]
Hemorrhage 1 [3.0] 1 [2.0]
Hyperplasia, Focal, Histiocytic 1 [3.0] 1 [2.0] 2 [2.0] 1 [3.0]
Infarct, Multiple 1 [3.0]
Metaplasia, Focal, Lipocyte 1 [2.0]
Necrosis 1 [4.0]
Pigmentation 1 [3.0]
Pigmentation, Focal 1 [3.0]
Capsule, Accessory Spleen, Focal 1 [2.0]
Capsule, Fibrosis, Focal 1 [2.0]
Lymphoid Follicle, Atrophy 1 [3.0]
Thymus (48) (48) (49) (47)
Angiectasis 1 [3.0]
Cyst 1 [2.0]
Hemorrhage 1 [3.0] 2 [2.5] 3 [2.3]
Hyperplasia, Lymphoid 2 [2.5] 1 [3.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 15
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (43) (47) (44)
Cyst 1 [3.0]
Dilatation 7 [2.7] 7 [2.7] 7 [2.1] 2 [2.5]
Hyperplasia 1 [2.0] 2 [2.5] 2 [3.0]
Inflammation, Chronic, Focal 1 [2.0] 1 [1.0]
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 3 [3.3] 1 [3.0] 3 [2.3] 1 [2.0]
Fibrosis, Focal 2 [3.0]
Hyperkeratosis, Focal 1 [3.0] 1 [3.0]
Inflammation, Chronic, Focal 2 [3.0]
Ulcer 1 [3.0]
Artery, Subcutaneous Tissue, Thrombosis 1 [3.0]
Epidermis, Hyperplasia, Focal 1 [3.0]
Lip, Inflammation, Chronic, Focal 1 [3.0]
Subcutaneous Tissue, Cyst 1 [4.0]
Subcutaneous Tissue, Cyst Epithelial
Inclusion 1 [3.0]
Subcutaneous Tissue, Hyperplasia, Focal,
Histiocytic 1 [3.0]
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 [3.0]
Subcutaneous Tissue, Inflammation, Chronic,
Focal, Suppurative 1 [3.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Cranium, Hyperostosis 1 [2.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression, Focal 6 [3.2] 6 [2.8] 7 [3.0] 6 [3.0]
Hemorrhage, Focal 2 [2.5] 2 [3.5] 4 [1.3] 6 [2.7]
Cerebrum, Ventricle, Hydrocephalus 1 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 16
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Lung (50) (50) (50) (50)
Congestion 2 [2.0] 1 [3.0] 3 [3.0]
Foreign Body, Focal 1 [2.0]
Hemorrhage 1 [2.0]
Hemorrhage, Focal 3 [1.3] 1 [2.0] 2 [2.0] 2 [2.0]
Hyperplasia, Focal, Histiocytic 1 [1.0] 1 [1.0]
Hyperplasia, Histiocytic 2 [1.0] 1 [1.0] 1 [1.0] 2 [1.0]
Infiltration Cellular, Mixed Cell 1 [2.0] 3 [2.0] 1 [2.0] 2 [2.5]
Inflammation, Chronic, Focal 5 [2.2] 2 [1.0] 3 [1.3] 3 [1.7]
Inflammation, Focal, Suppurative 1 [3.0]
Alveolar Epithelium, Hyperplasia, Focal 8 [1.9] 5 [1.6] 3 [2.0] 4 [2.8]
Alveolar Epithelium, Metaplasia, Squamous 1 [3.0]
Alveolus, Edema, Focal 1 [2.0]
Alveolus, Hyperplasia, Focal, Histiocytic 1 [3.0]
Interstitium, Edema 1 [3.0] 1 [3.0]
Mediastinum, Edema 1 [3.0] 1 [3.0]
Nose (49) (49) (49) (50)
Foreign Body 1 [2.0] 2 [2.0] 1 [2.0]
Inflammation, Chronic 1 [2.0]
Inflammation, Suppurative 1 [2.0] 1 [3.0] 6 [2.0] 1 [2.0]
Nasolacrimal Duct, Inflammation 1 [1.0] 3 [2.0] 1 [2.0]
Olfactory Epithelium, Hyperplasia, Focal 1 [2.0]
Respiratory Epithelium, Hyperplasia, Focal 1 [3.0]
Trachea (50) (49) (50) (50)
Peritracheal Tissue, Edema 1 [3.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (48) (46) (50)
Atrophy 2 [3.0]
Cataract 2 [2.5] 1 [3.0] 2 [2.5]
Exudate 1 [3.0]
Cornea, Inflammation, Chronic 1 [3.0]
Cornea, Retrobulbar, Inflammation, Chronic
Active 1 [3.0]
Retina, Degeneration 2 [3.5] 1 [3.0] 2 [3.0]
Harderian Gland (49) (49) (49) (50)
Fibrosis, Focal 1 [2.0]
Hyperplasia, Focal, Histiocytic 1 [2.0] 1 [2.0] 1 [1.0]
Inflammation, Chronic, Focal 1 [3.0] 1 [1.0] 1 [2.0]
Inflammation, Chronic Active, Diffuse 1 [4.0]
Epithelium, Hyperplasia, Focal 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 17
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/27/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 14:06:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (47) (46) (49) (49)
Cyst 1 [2.0]
Cyst, Multiple 1 [2.0]
Hydronephrosis 1 [4.0]
Infarct 1 [3.0]
Infarct, Multiple 1 [4.0] 1 [3.0]
Metaplasia, Focal, Lipocyte 1 [3.0]
Nephropathy 45 [1.6] 44 [1.7] 48 [1.8] 47 [1.7]
Cortex, Medulla, Atrophy 1 [4.0]
Pelvis, Infiltration Cellular, Mixed Cell 1 [2.0]
Pelvis, Transitional Epithelium, Hyperplasia 1 [2.0] 1 [2.0]
Renal Tubule, Accumulation, Hyaline Droplet 1 [2.0] 4 [2.3] 2 [2.5]
Renal Tubule, Hyperplasia, Focal 1 [2.0]
Renal Tubule, Pigmentation 4 [2.3] 4 [1.8] 1 [2.0] 4 [2.8]
Urinary Bladder (48) (49) (47) (50)
Calculus Micro Observation Only 1 [3.0]
Edema 2 [3.0]
Hemorrhage 2 [2.0]
Inflammation, Chronic 1 [4.0]
Serosa, Inflammation, Focal 1 [2.0]
Transitional Epithelium, Hyperplasia, Diffuse 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 18
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