TDMS Study 96010-04 Pathology Tables
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
FINAL#1/MICE
Facility: Southern Research Institute
Chemical CAS #: 7775-09-9
Lock Date: 10/16/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 10 10 12 7
Moribund Sacrifice 3 5 6 8
Accidently Killed 1
Survivors
Terminal Sacrifice 36 34 31 35
Moribund Sacrifice 1
Other 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (49) (48) (49)
Hemorrhage 1 (2%)
Intestine Large, Cecum (44) (47) (47) (47)
Edema 4 (9%) 6 (13%) 6 (13%) 6 (13%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
Intestine Small, Duodenum (46) (47) (47) (50)
Ulcer 1 (2%) 1 (2%)
Epithelium, Hyperplasia 2 (4%)
Intestine Small, Ileum (42) (45) (46) (47)
Inflammation, Chronic 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Liver (49) (50) (49) (50)
Angiectasis 2 (4%) 2 (4%) 1 (2%)
Basophilic Focus 5 (10%) 4 (8%) 1 (2%)
Clear Cell Focus 3 (6%) 1 (2%)
Eosinophilic Focus 9 (18%) 9 (18%) 13 (27%) 7 (14%)
Hematopoietic Cell Proliferation 7 (14%) 4 (8%) 3 (6%) 8 (16%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Hyperplasia, Lymphoid 4 (8%) 7 (14%) 3 (6%) 5 (10%)
Infarct 1 (2%)
Infiltration Cellular, Mixed Cell 7 (14%) 7 (14%) 8 (16%) 7 (14%)
Mixed Cell Focus 7 (14%) 2 (4%) 3 (6%) 3 (6%)
Necrosis, Focal 5 (10%) 1 (2%) 4 (8%) 1 (2%)
Tension Lipidosis 2 (4%) 3 (6%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Necrosis 2 (4%) 2 (4%) 2 (4%) 2 (4%)
Hepatocyte, Karyomegaly 3 (6%)
Hepatocyte, Vacuolization Cytoplasmic 4 (8%) 3 (6%) 6 (12%) 4 (8%)
Kupffer Cell, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Kupffer Cell, Pigmentation 3 (6%) 4 (8%) 4 (8%) 7 (14%)
Mesentery (30) (32) (27) (24)
Angiectasis 1 (3%) 1 (4%)
Hemorrhage 1 (3%)
Inflammation, Chronic 1 (4%)
Fat, Necrosis 21 (70%) 24 (75%) 20 (74%) 16 (67%)
Pancreas (46) (47) (49) (48)
Atrophy 2 (4%) 1 (2%) 1 (2%)
Cyst 1 (2%) 1 (2%)
Acinus, Hyperplasia, Focal 1 (2%)
Salivary Glands (48) (47) (49) (50)
Hyperplasia, Lymphoid 16 (33%) 21 (45%) 15 (31%) 18 (36%)
Stomach, Forestomach (49) (50) (50) (49)
Diverticulum 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Edema 3 (6%)
Erosion 1 (2%) 2 (4%) 2 (4%)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%)
Ulcer 2 (4%) 3 (6%) 3 (6%)
Epithelium, Hyperplasia 3 (6%) 4 (8%) 9 (18%) 6 (12%)
Stomach, Glandular (49) (48) (50) (49)
Erosion 1 (2%) 2 (4%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (3) (1)
Aorta, Mineralization 1 (33%)
Heart (49) (50) (49) (50)
Cardiomyopathy 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (49) (50)
Accessory Adrenal Cortical Nodule 4 (8%) 2 (4%) 7 (14%) 7 (14%)
Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Capsule, Hyperplasia 1 (2%) 2 (4%)
Zona Reticularis, Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Adrenal Medulla (50) (49) (49) (50)
Hyperplasia 2 (4%) 2 (4%) 1 (2%)
Islets, Pancreatic (46) (47) (49) (49)
Hyperplasia 9 (20%) 6 (13%) 4 (8%) 3 (6%)
Parathyroid Gland (45) (47) (48) (47)
Cyst 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Pituitary Gland (46) (45) (48) (50)
Pars Distalis, Angiectasis 1 (2%) 2 (4%) 2 (4%)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia, Focal 3 (7%) 3 (7%) 3 (6%) 1 (2%)
Thyroid Gland (48) (50) (49) (50)
Degeneration, Cystic 25 (52%) 28 (56%) 34 (69%) 32 (64%)
Follicle, Cyst 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Cyst 2 (4%)
Follicular Cell, Hypertrophy 3 (6%) 2 (4%) 5 (10%) 14 (28%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (47) (47) (49)
Inflammation, Chronic 2 (4%) 4 (8%)
Ovary (45) (45) (47) (50)
Angiectasis 3 (7%) 2 (4%) 4 (9%) 3 (6%)
Cyst 9 (20%) 14 (31%) 14 (30%) 13 (26%)
Cyst, Hemorrhagic 1 (2%)
Hemorrhage 1 (2%)
Thrombosis 3 (7%) 1 (2%) 1 (2%)
Bilateral, Cyst 1 (2%)
Follicle, Hemorrhage 1 (2%) 4 (9%) 4 (9%) 9 (18%)
Granulosa Cell, Hyperplasia 3 (6%) 7 (14%)
Uterus (50) (50) (50) (50)
Angiectasis 1 (2%) 2 (4%) 1 (2%)
Hyperplasia, Atypical 1 (2%)
Hyperplasia, Cystic 45 (90%) 45 (90%) 40 (80%) 41 (82%)
Inflammation, Chronic 2 (4%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Metaplasia, Squamous 2 (4%) 1 (2%)
Endometrium, Hyperplasia, Atypical 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 14 (28%) 28 (56%) 29 (58%) 31 (62%)
Myelofibrosis 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Lymph Node (7) (5) (11) (9)
Iliac, Hemorrhage 1 (9%)
Iliac, Hyperplasia, Lymphoid 1 (14%) 1 (11%)
Mediastinal, Hyperplasia, Lymphoid 1 (14%) 1 (20%) 2 (18%)
Mediastinal, Pigmentation 1 (14%)
Pancreatic, Hemorrhage 1 (11%)
Renal, Hemorrhage 1 (14%) 1 (11%)
Lymph Node, Mandibular (46) (46) (49) (49)
Atrophy 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 12 (26%) 7 (15%) 7 (14%) 10 (20%)
Pigmentation 18 (39%) 16 (35%) 18 (37%) 15 (31%)
Lymph Node, Mesenteric (47) (49) (49) (49)
Atrophy 1 (2%) 1 (2%) 2 (4%)
Ectasia 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Hemorrhage 4 (9%) 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 10 (21%) 8 (16%) 11 (22%) 6 (12%)
Pigmentation 1 (2%) 2 (4%)
Spleen (49) (48) (49) (50)
Accessory Spleen 1 (2%)
Hematopoietic Cell Proliferation 39 (80%) 39 (81%) 35 (71%) 39 (78%)
Hyperplasia, Lymphoid 11 (22%) 10 (21%) 5 (10%) 9 (18%)
Pigmentation 28 (57%) 30 (63%) 28 (57%) 27 (54%)
Lymphoid Follicle, Atrophy 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Thymus (48) (44) (48) (48)
Atrophy 5 (10%) 7 (16%) 5 (10%) 9 (19%)
Cyst 3 (6%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 5 (10%) 3 (7%) 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Hyperplasia 5 (10%) 11 (22%) 8 (16%) 10 (20%)
Skin (48) (50) (50) (50)
Edema 1 (2%) 1 (2%)
Epidermis, Hyperplasia 1 (2%) 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Callus 1 (2%)
Fracture 1 (2%) 1 (2%)
Hyperostosis 1 (2%) 1 (2%) 4 (8%) 3 (6%)
Cranium, Osteopetrosis 1 (2%)
Femur, Osteopetrosis 1 (2%) 1 (2%)
Skeletal Muscle (2) (4) (6)
Angiectasis 1 (17%)
Atrophy 1 (17%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%) 1 (2%)
Peripheral Nerve (2) (2)
Atrophy 1 (50%) 2 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50)
Edema 5 (10%) 8 (16%) 3 (6%) 5 (10%)
Foreign Body 2 (4%)
Hemorrhage 5 (10%) 8 (16%) 6 (12%) 4 (8%)
Hyperplasia, Lymphoid 10 (20%) 8 (16%) 3 (6%) 9 (18%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 3 (6%) 5 (10%)
Metaplasia, Osseous 1 (2%) 2 (4%)
Thrombosis 1 (2%) 4 (8%) 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 2 (4%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (48) (50) (50)
Inflammation, Chronic 3 (6%) 3 (6%)
Cornea, Hyperplasia 2 (4%) 1 (2%)
Harderian Gland (50) (50) (50) (49)
Cyst 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (50)
Hydronephrosis 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 8 (16%) 9 (18%) 6 (12%) 8 (16%)
Infarct 3 (6%) 2 (4%) 4 (8%) 5 (10%)
Metaplasia, Osseous 1 (2%) 3 (6%) 2 (4%)
Nephropathy 14 (28%) 11 (22%) 14 (29%) 12 (24%)
Renal Tubule, Accumulation, Hyaline Droplet 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Renal Tubule, Dilatation 1 (2%) 1 (2%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 3 (6%) 1 (2%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (49) (50) (50) (50)
Hyperplasia, Lymphoid 4 (8%) 12 (24%) 4 (8%) 5 (10%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 7 4 5 7
Moribund Sacrifice 5 5 4 10
Survivors
Terminal Sacrifice 38 41 41 33
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (47) (49) (49) (48)
Edema 1 (2%) 3 (6%) 4 (8%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%)
Intestine Small, Duodenum (48) (50) (49) (49)
Ulcer 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Intestine Small, Jejunum (47) (49) (50) (50)
Epithelium, Hyperplasia 2 (4%)
Intestine Small, Ileum (47) (49) (49) (49)
Cyst 1 (2%)
Liver (48) (50) (50) (50)
Angiectasis 2 (4%) 2 (4%)
Basophilic Focus 2 (4%) 3 (6%) 4 (8%)
Clear Cell Focus 12 (25%) 19 (38%) 19 (38%) 13 (26%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 11 (23%) 10 (20%) 5 (10%) 11 (22%)
Hematopoietic Cell Proliferation 1 (2%) 4 (8%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Mixed Cell 2 (4%) 1 (2%) 1 (2%)
Mixed Cell Focus 2 (4%) 9 (18%) 8 (16%) 7 (14%)
Necrosis, Focal 4 (8%) 6 (12%) 7 (14%) 6 (12%)
Regeneration, Focal 1 (2%)
Tension Lipidosis 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 2 (4%)
Centrilobular, Necrosis 1 (2%) 2 (4%)
Hepatocyte, Karyomegaly 1 (2%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 2 (4%) 3 (6%)
Kupffer Cell, Pigmentation 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (9) (10) (10) (8)
Infarct 1 (10%)
Inflammation, Chronic 1 (11%) 2 (25%)
Fat, Necrosis 3 (33%) 8 (80%) 6 (60%) 5 (63%)
Pancreas (48) (50) (50) (50)
Cyst 2 (4%)
Acinus, Cytoplasmic Alteration 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 7 (14%) 3 (6%) 6 (12%) 4 (8%)
Stomach, Forestomach (49) (50) (50) (50)
Cyst 2 (4%)
Diverticulum 1 (2%) 1 (2%) 2 (4%)
Erosion 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%) 4 (8%) 2 (4%)
Ulcer 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Epithelium, Hyperplasia 3 (6%) 7 (14%) 2 (4%) 4 (8%)
Stomach, Glandular (48) (50) (50) (50)
Cyst 1 (2%) 2 (4%) 1 (2%)
Ulcer 1 (2%)
Tooth (2) (4) (1) (3)
Malformation 2 (100%) 4 (100%) 2 (67%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 2 (4%)
Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%) 2 (4%)
Thrombosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 6 (12%) 5 (10%) 3 (6%) 5 (10%)
Degeneration, Fatty 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Focal 4 (8%) 6 (12%) 7 (14%) 9 (18%)
Hypertrophy 1 (2%)
Hypertrophy, Focal 9 (18%) 16 (32%) 11 (22%) 11 (22%)
Capsule, Hyperplasia 5 (10%) 3 (6%) 1 (2%) 8 (16%)
Adrenal Medulla (49) (48) (49) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (48) (50) (50) (50)
Hyperplasia 31 (65%) 25 (50%) 28 (56%) 23 (46%)
Parathyroid Gland (46) (48) (47) (49)
Cyst 1 (2%) 2 (4%) 1 (2%)
Pituitary Gland (47) (47) (45) (49)
Pars Distalis, Cyst 1 (2%) 1 (2%) 2 (4%) 5 (10%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (48) (50) (48) (50)
Degeneration, Cystic 13 (27%) 17 (34%) 14 (29%) 15 (30%)
Follicular Cell, Hypertrophy 2 (4%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Atypia Cellular 1 (2%) 6 (12%) 4 (8%) 3 (6%)
Granuloma Sperm 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Preputial Gland (50) (50) (50) (50)
Cyst 22 (44%) 26 (52%) 15 (30%) 29 (58%)
Inflammation, Chronic 28 (56%) 27 (54%) 18 (36%) 21 (42%)
Prostate (50) (50) (50) (50)
Inflammation, Chronic 1 (2%) 4 (8%) 3 (6%) 5 (10%)
Seminal Vesicle (50) (50) (50) (50)
Degeneration 1 (2%) 2 (4%)
Dilatation 1 (2%)
Inflammation, Chronic 3 (6%) 1 (2%)
Testes (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Necrosis 1 (2%)
Germinal Epithelium, Atrophy 1 (2%) 5 (10%) 3 (6%) 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia 21 (43%) 12 (24%) 13 (26%) 15 (30%)
Lymph Node (3) (1) (3)
Mediastinal, Hemorrhage 1 (33%)
Lymph Node, Mandibular (49) (48) (45) (49)
Atrophy 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 14 (29%) 14 (29%) 16 (36%) 16 (33%)
Pigmentation 7 (14%) 10 (21%) 9 (20%) 9 (18%)
Lymph Node, Mesenteric (47) (50) (50) (50)
Atrophy 2 (4%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 4 (8%) 1 (2%)
Hemorrhage 4 (9%) 6 (12%) 2 (4%) 4 (8%)
Hyperplasia, Lymphoid 11 (23%) 6 (12%) 6 (12%) 9 (18%)
Spleen (48) (50) (50) (50)
Depletion Lymphoid 1 (2%)
Hematopoietic Cell Proliferation 21 (44%) 17 (34%) 18 (36%) 21 (42%)
Hyperplasia, Lymphoid 8 (17%) 9 (18%) 10 (20%) 8 (16%)
Pigmentation 3 (6%) 1 (2%) 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 3 (6%)
Thymus (43) (43) (40) (44)
Atrophy 11 (26%) 13 (30%) 4 (10%) 13 (30%)
Cyst 1 (2%) 3 (7%) 4 (10%) 4 (9%)
Hyperplasia, Lymphoid 2 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Edema 3 (6%)
Inflammation, Chronic 1 (2%) 1 (2%)
Ulcer 2 (4%)
Epidermis, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fracture 1 (2%) 1 (2%) 2 (4%)
Hyperostosis 1 (2%) 1 (2%)
Skeletal Muscle (3) (1) (3) (2)
Atrophy 1 (100%)
Infiltration Cellular, Lipocyte 1 (33%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Peripheral Nerve (1) (2) (1)
Atrophy 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Edema 6 (12%) 11 (22%) 7 (14%) 8 (16%)
Foreign Body 1 (2%) 1 (2%)
Hemorrhage 5 (10%) 3 (6%) 4 (8%) 5 (10%)
Hyperplasia, Lymphoid 4 (8%) 5 (10%) 7 (14%) 6 (12%)
Infiltration Cellular, Histiocyte 8 (16%) 5 (10%) 9 (18%) 10 (20%)
Metaplasia, Osseous 2 (4%)
Alveolar Epithelium, Hyperplasia 2 (4%) 3 (6%) 1 (2%) 5 (10%)
Nose (50) (50) (50) (50)
Foreign Body 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%) 2 (4%) 1 (2%) 5 (10%)
Respiratory Epithelium, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (50) (50) (50)
Cataract 1 (2%)
Inflammation, Chronic 3 (6%)
Harderian Gland (50) (50) (50) (49)
Hyperplasia, Focal 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 3 (6%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Cyst 14 (29%) 10 (20%) 9 (18%) 10 (20%)
Hydronephrosis 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 8 (16%) 6 (12%) 4 (8%) 11 (22%)
Infarct 5 (10%) 1 (2%) 4 (8%) 5 (10%)
Inflammation, Chronic 1 (2%) 1 (2%)
Metaplasia, Osseous 7 (14%) 5 (10%) 3 (6%) 4 (8%)
Nephropathy 37 (76%) 42 (84%) 43 (86%) 36 (72%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:32:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Dilatation 1 (2%) 2 (4%) 3 (6%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Renal Tubule, Necrosis 1 (2%) 2 (4%)
Renal Tubule, Pigmentation 2 (4%) 1 (2%) 1 (2%)
Urethra (1)
Angiectasis 1 (100%)
Urinary Bladder (49) (50) (50) (50)
Edema 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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