TDMS Study 96010-04 Pathology Tables
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
FINAL#1/MICE
Facility: Southern Research Institute
Chemical CAS #: 7775-09-9
Lock Date: 10/16/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 10 10 12 7
Moribund Sacrifice 3 5 6 8
Accidently Killed 1
Survivors
Terminal Sacrifice 36 34 31 35
Moribund Sacrifice 1
Other 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (50) (50)
Gallbladder (40) (44) (44) (48)
Intestine Large, Cecum (44) (47) (47) (47)
Hemangioma 1 (2%)
Intestine Small, Duodenum (46) (47) (47) (50)
Adenoma 1 (2%)
Polyp Adenomatous 1 (2%)
Intestine Small, Jejunum (45) (47) (47) (47)
Histiocytic Sarcoma 1 (2%)
Intestine Small, Ileum (42) (45) (46) (47)
Liver (49) (50) (49) (50)
Hemangioma 2 (4%)
Hemangiosarcoma 1 (2%) 2 (4%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatoblastoma 1 (2%)
Hepatocellular Carcinoma 2 (4%) 6 (12%) 11 (22%) 6 (12%)
Hepatocellular Carcinoma, Multiple 1 (2%) 7 (14%) 4 (8%) 3 (6%)
Hepatocellular Adenoma 15 (31%) 9 (18%) 14 (29%) 8 (16%)
Hepatocellular Adenoma, Multiple 15 (31%) 10 (20%) 12 (24%) 15 (30%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesentery (30) (32) (27) (24)
Fibrosarcoma 1 (4%)
Fibrous Histiocytoma 1 (3%)
Hemangiosarcoma 1 (4%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (4%)
Histiocytic Sarcoma 1 (4%)
Page 2
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Sarcoma, Metastatic, Skin 1 (4%)
Schwannoma Malignant, Metastatic, Skin 1 (3%)
Oral Mucosa (2) (1)
Squamous Cell Carcinoma 1 (50%)
Squamous Cell Papilloma 1 (100%)
Pancreas (46) (47) (49) (48)
Fibrosarcoma, Metastatic, Mesentery 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Acinus, Sarcoma 1 (2%)
Salivary Glands (48) (47) (49) (50)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Stomach, Forestomach (49) (50) (50) (49)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Squamous Cell Papilloma, Multiple 1 (2%)
Stomach, Glandular (49) (48) (50) (49)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Tongue (2)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (49) (50)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (49) (50)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Subcapsular, Adenoma 1 (2%)
Adrenal Medulla (50) (49) (49) (50)
Pheochromocytoma Malignant 2 (4%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (46) (47) (49) (49)
Adenoma 2 (4%) 2 (4%) 3 (6%)
Carcinoma 1 (2%)
Pituitary Gland (46) (45) (48) (50)
Page 3
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Histiocytic Sarcoma 1 (2%)
Pars Distalis, Adenoma 3 (7%) 2 (4%) 4 (8%) 4 (8%)
Thyroid Gland (48) (50) (49) (50)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (47) (47) (49)
Ovary (45) (45) (47) (50)
Choriocarcinoma 2 (4%)
Cystadenoma 1 (2%) 4 (9%) 1 (2%) 1 (2%)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 1 (2%) 1 (2%) 1 (2%) 5 (10%)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Luteoma 3 (7%) 1 (2%)
Yolk Sac Carcinoma 1 (2%)
Uterus (50) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 1 (2%) 3 (6%)
Yolk Sac Carcinoma, Metastatic, Ovary 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hemangiosarcoma 1 (2%) 1 (2%) 2 (4%)
Histiocytic Sarcoma 1 (2%)
Lymph Node (7) (5) (11) (9)
Histiocytic Sarcoma 1 (9%)
Liposarcoma, Metastatic, Skin 1 (20%)
Iliac, Histiocytic Sarcoma 2 (18%)
Iliac, Liposarcoma, Metastatic, Skin 1 (20%)
Mediastinal, Sarcoma, Metastatic, Pancreas 1 (9%)
Pancreatic, Histiocytic Sarcoma 1 (9%)
Renal, Histiocytic Sarcoma 1 (9%) 1 (11%)
Page 4
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Lymph Node, Mandibular (46) (46) (49) (49)
Histiocytic Sarcoma 2 (4%)
Squamous Cell Carcinoma, Metastatic,
Uncertain Primary Site 1 (2%)
Lymph Node, Mesenteric (47) (49) (49) (49)
Histiocytic Sarcoma 1 (2%) 2 (4%)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (2%)
Yolk Sac Carcinoma, Metastatic, Ovary 1 (2%)
Spleen (49) (48) (49) (50)
Hemangiosarcoma 2 (4%) 1 (2%) 1 (2%)
Histiocytic Sarcoma 2 (4%)
Sarcoma, Metastatic, Skin 1 (2%)
Thymus (48) (44) (48) (48)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Skin (48) (50) (50) (50)
Hemangioma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (4%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 3 (6%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%) 1 (2%) 2 (4%)
Sarcoma 1 (2%)
Skeletal Muscle (2) (4) (6)
Histiocytic Sarcoma, Metastatic, Mesentery 1 (25%)
Rhabdomyosarcoma 1 (50%) 1 (25%) 2 (33%)
Sarcoma, Metastatic, Pancreas 1 (25%)
Sarcoma, Metastatic, Skin 1 (17%)
Page 5
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont
Yolk Sac Carcinoma, Metastatic, Ovary 1 (17%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 1 (2%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 3 (6%) 5 (10%) 2 (4%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Liposarcoma, Metastatic, Skin 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Sarcoma, Metastatic, Skin 1 (2%)
Nose (50) (50) (50) (50)
Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (48) (50) (50)
Harderian Gland (50) (50) (50) (49)
Adenoma 11 (22%) 9 (18%) 5 (10%) 6 (12%)
Carcinoma 1 (2%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (50)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Urinary Bladder (49) (50) (50) (50)
Page 6
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 4 (8%) 2 (4%)
Leukemia Granulocytic 1 (2%)
Lymphoma Malignant 23 (46%) 19 (38%) 28 (56%) 27 (54%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 7
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 45 46 47
Total Primary Neoplasms 99 87 108 105
Total Animals with Benign Neoplasms 38 27 33 31
Total Benign Neoplasms 58 40 44 53
Total Animals with Malignant Neoplasms 33 38 41 41
Total Malignant Neoplasms 41 47 64 52
Total Animals with Metastatic Neoplasms 2 5 10 5
Total Metastatic Neoplasm 2 8 20 11
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 8
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 7 4 5 7
Moribund Sacrifice 5 5 4 10
Survivors
Terminal Sacrifice 38 41 41 33
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (50) (50) (50)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Intestine Large, Cecum (47) (49) (49) (48)
Carcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Intestine Small, Duodenum (48) (50) (49) (49)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Polyp Adenomatous 2 (4%)
Intestine Small, Jejunum (47) (49) (50) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 2 (4%) 2 (4%) 2 (4%)
Liver (48) (50) (50) (50)
Carcinoma, Metastatic, Islets, Pancreatic 1 (2%)
Cholangiocarcinoma 1 (2%) 1 (2%)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatoblastoma 5 (10%) 3 (6%) 1 (2%) 3 (6%)
Hepatoblastoma, Multiple 1 (2%)
Hepatocellular Carcinoma 14 (29%) 13 (26%) 14 (28%) 12 (24%)
Hepatocellular Carcinoma, Multiple 6 (13%) 1 (2%) 5 (10%) 1 (2%)
Hepatocellular Adenoma 16 (33%) 15 (30%) 13 (26%) 14 (28%)
Hepatocellular Adenoma, Multiple 14 (29%) 17 (34%) 23 (46%) 16 (32%)
Histiocytic Sarcoma 1 (2%) 2 (4%) 2 (4%)
Ito Cell Tumor Malignant 1 (2%)
Leiomyosarcoma, Metastatic, Mesentery 1 (2%)
Page 9
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Mesentery (9) (10) (10) (8)
Cholangiocarcinoma, Metastatic, Liver 1 (11%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (10%) 1 (13%)
Histiocytic Sarcoma 2 (25%)
Histiocytic Sarcoma, Metastatic, Liver 1 (11%)
Ito Cell Tumor Malignant, Metastatic, Liver 1 (10%)
Leiomyosarcoma 1 (11%)
Liposarcoma 1 (10%)
Pancreas (48) (50) (50) (50)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (2%)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Salivary Glands (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Stomach, Forestomach (49) (50) (50) (50)
Leiomyosarcoma, Metastatic, Mesentery 1 (2%)
Squamous Cell Papilloma 2 (4%) 2 (4%)
Stomach, Glandular (48) (50) (50) (50)
Adenoma 2 (4%)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Leiomyosarcoma, Metastatic, Mesentery 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Bilateral, Subcapsular, Adenoma 1 (2%)
Subcapsular, Adenoma 1 (2%) 3 (6%) 4 (8%) 2 (4%)
Islets, Pancreatic (48) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (47) (47) (45) (49)
Pars Distalis, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Cholangiocarcinoma, Metastatic, Liver 1 (2%)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Prostate (50) (50) (50) (50)
Seminal Vesicle (50) (50) (50) (50)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Testes (50) (50) (50) (50)
Interstitial Cell, Adenoma 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Histiocytic Sarcoma 1 (2%)
Lymph Node (3) (1) (3)
Mediastinal, Carcinoma, Metastatic,
Harderian Gland 1 (33%)
Mediastinal, Hepatocellular Carcinoma,
Metastatic, Liver 1 (100%) 1 (33%)
Mediastinal, Histiocytic Sarcoma, Metastatic,
Liver 1 (33%)
Mediastinal, Leiomyosarcoma, Metastatic,
Mesentery 1 (33%)
Pancreatic, Hepatocellular Carcinoma,
Metastatic, Liver 1 (100%)
Pancreatic, Histiocytic Sarcoma, Metastatic,
Liver 1 (33%)
Renal, Hepatocellular Carcinoma, Metastatic,
Liver 1 (100%)
Renal, Histiocytic Sarcoma, Metastatic, Liver 1 (33%)
Renal, Leiomyosarcoma, Metastatic, Mesentery 1 (33%)
Lymph Node, Mandibular (49) (48) (45) (49)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (47) (50) (50) (50)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Page 11
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Histiocytic Sarcoma 1 (2%)
Leiomyosarcoma, Metastatic, Mesentery 1 (2%)
Spleen (48) (50) (50) (50)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Leiomyosarcoma, Metastatic, Mesentery 1 (2%)
Thymus (43) (43) (40) (44)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (3%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (3%)
Leiomyosarcoma, Metastatic, Mesentery 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Skeletal Muscle (3) (1) (3) (2)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 2 (67%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (50%)
Histiocytic Sarcoma, Metastatic, Liver 1 (33%)
Leiomyosarcoma, Metastatic, Mesentery 1 (33%)
Rhabdomyosarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 12
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 6 (12%) 4 (8%) 7 (14%) 6 (12%)
Alveolar/Bronchiolar Carcinoma 4 (8%) 5 (10%) 6 (12%) 4 (8%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatoblastoma, Metastatic, Liver 1 (2%) 2 (4%)
Hepatocellular Carcinoma, Metastatic, Liver 9 (18%) 2 (4%) 4 (8%) 6 (12%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Histiocytic Sarcoma, Metastatic, Liver 1 (2%)
Leiomyosarcoma, Metastatic, Mesentery 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (50) (50) (50) (49)
Adenoma 6 (12%) 4 (8%) 4 (8%) 6 (12%)
Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 2 (4%) 3 (6%)
Lymphoma Malignant 3 (6%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 13
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 03/26/03
Route: DOSED WATER Time: 10:40:52
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 45 47 45
Total Primary Neoplasms 86 76 95 87
Total Animals with Benign Neoplasms 34 38 37 34
Total Benign Neoplasms 47 48 59 51
Total Animals with Malignant Neoplasms 29 22 30 27
Total Malignant Neoplasms 39 28 36 36
Total Animals with Metastatic Neoplasms 12 5 9 8
Total Metastatic Neoplasm 38 5 20 14
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 14
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