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TDMS Study 96010-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 03/26/03       
EXPERIMENT: 96010 TEST: 04                                                                                     TIME: 10:41:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 7775-09-9       
------------------------------------------------------------------------------------------------------------------------------------
                                                            FINAL#1/MICE                                                            
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 03/26/03       
EXPERIMENT: 96010 TEST: 04                                                                                     TIME: 10:41:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 7775-09-9       
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 03/26/03       
EXPERIMENT: 96010 TEST: 04                                                                                     TIME: 10:41:04       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 7775-09-9       
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF     WATER DISINFECTION BYPRODUCTS (SODIUM                                                                        
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Liver                                  Hepatoblastoma                                                                               
Testes                                 Adenoma                                                                                      
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Medulla                        Pheochromocytoma Malignant                                                                   
Islets, Pancreatic                     Carcinoma or Adenoma                                                                         
Liver                                  Hemangioma                                                                                   
                                       Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma                                                                     
                                       Hepatocellular Carcinoma or Hepatoblastoma                                                   
Ovary                                  Granulosa Cell Tumor Benign                                                                  
                                       Granulosa Cell Tumor: Benign, Malignant, NOS                                                 
                                       Luteoma                                                                                      
Skin                                   Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                 
                                       Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                  
Uterus                                 Polyp Stromal                                                                                
All Organs                             Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
===============================================================                                                                     
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -      WATER DISINFECTION BYPRODUCTS (SODIUM     
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    5/50 (10%)   3/50 (6%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/44.60      4/47.28      5/46.48      3/43.80     |1/43.63      0/44.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     6.7%         8.5%         10.8%        6.9%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/38 (8%)    4/41 (10%)   5/41 (12%)   3/33 (9%)   |1/36 (3%)    0/34 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.500      P=0.542      P=0.398      P=0.597     |P=0.313N     P=0.511N     P=0.530N     P=0.506N     | 
|POLY 3             |     P=0.566      P=0.532      P=0.379      P=0.654     |P=0.310N     P=0.497N     P=0.508N     P=0.501N     | 
|POLY 1.5           |     P=0.566N     P=0.519      P=0.372      P=0.658     |P=0.309N     P=0.499N     P=0.509N     P=0.502N     | 
|POLY 6             |     P=0.550      P=0.547      P=0.387      P=0.648     |P=0.313N     P=0.493N     P=0.507N     P=0.500N     | 
|LOGISTIC REGRESSION|     P=0.500      P=0.542      P=0.398      P=0.597     |P=0.313N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.554N     P=0.500      P=0.357      P=0.661N    |P=0.306N     P=0.505N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.564      (e)          (e)          (e)         |P=0.121N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Malignant                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)   |2/50 (4%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.98      0/45.28      0/45.48      0/42.80     |2/43.88      0/44.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.6%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/39 (0%)    0/40 (0%)    0/32 (0%)   |1/36 (3%)    0/34 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |660          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.119N     P=0.233N     P=0.256N     P=0.237N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.117N     P=0.235N     P=0.247N     P=0.239N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.116N     P=0.237N     P=0.248N     P=0.240N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.118N     P=0.232N     P=0.247N     P=0.239N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.116N     P=0.241N     P=0.245N     P=0.238N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.253N     P=0.253N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.030N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/49 (0%)    0/49 (0%)   |3/50 (6%)    0/49 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.98      0/45.28      0/45.48      0/42.80     |3/43.88      0/44.35      0/42.00      2/43.58      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.8%         0.0%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/38 (0%)    0/39 (0%)    0/40 (0%)    0/32 (0%)   |2/36 (6%)    0/34 (0%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |660          ---          ---          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.532N     P=0.122N     P=0.141N     P=0.496N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.538N     P=0.117N     P=0.126N     P=0.503N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.536N     P=0.119N     P=0.127N     P=0.504N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.541N     P=0.114N     P=0.127N     P=0.501N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.535N     P=0.119N     P=0.127N     P=0.502N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.529N     P=0.125N     P=0.125N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.102N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |0/43.63      1/45.39      1/42.71      2/44.56      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         2.3%         4.5%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          719          622          447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.154      P=0.505      P=0.495      P=0.247      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.156      P=0.508      P=0.496      P=0.242      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.154      P=0.505      P=0.495      P=0.239      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.159      P=0.512      P=0.496      P=0.246      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.167      P=0.511      P=0.520      P=0.273      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.153      P=0.500      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.122      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.53      0/47.28      0/46.48      0/43.80     |1/44.05      1/45.35      2/42.58      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         2.2%         4.7%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    1/35 (3%)    1/31 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |606          729 (T)      662          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.371N     P=0.758N     P=0.483      P=0.495N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.376N     P=0.754N     P=0.488      P=0.503N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.374N     P=0.756N     P=0.489      P=0.503N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.377N     P=0.752N     P=0.487      P=0.503N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.366N     P=0.752      P=0.506      P=0.482N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.366N     P=0.753N     P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.274N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    4/50 (8%)    6/50 (12%)  |11/50 (22%)  9/50 (18%)   5/50 (10%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     6/45.47      4/47.40      4/47.28      6/44.51     |11/44.13     9/45.61      5/42.40      6/43.85      | 
|POLY-3 PERCENT (g) |     13.2%        8.4%         8.5%         13.5%       |24.9%        19.7%        11.8%        13.7%        | 
|TERMINAL (d)       |     4/38 (11%)   3/41 (7%)    2/41 (5%)    3/33 (9%)   |10/36 (28%)  7/35 (20%)   4/31 (13%)   5/35 (14%)   | 
|FIRST INCIDENCE    |     562          698          543          605         |576          673          712          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.422      P=0.323N     P=0.333N     P=0.556     |P=0.104N     P=0.420N     P=0.142N     P=0.157N     | 
|POLY 3             |     P=0.478      P=0.344N     P=0.345N     P=0.606     |P=0.093N     P=0.368N     P=0.095N     P=0.142N     | 
|POLY 1.5           |     P=0.487      P=0.353N     P=0.353N     P=0.612     |P=0.093N     P=0.380N     P=0.095N     P=0.145N     | 
|POLY 6             |     P=0.466      P=0.332N     P=0.338N     P=0.596     |P=0.092N     P=0.351N     P=0.097N     P=0.137N     | 
|LOGISTIC REGRESSION|     P=0.511      P=0.375N     P=0.417N     P=0.621N    |P=0.093N     P=0.348N     P=0.095N     P=0.143N     | 
|COCH-ARM / FISHERS |     P=0.500      P=0.370N     P=0.370N     P=0.620N    |P=0.088N     P=0.402N     P=0.086N     P=0.143N     | 
|ORDER RESTRICTED   |     P=0.473      (e)          (e)          (e)         |P=0.100N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    5/50 (10%)   7/50 (14%)  |12/50 (24%)  10/50 (20%)  5/50 (10%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     6/45.47      4/47.40      5/47.28      7/44.97     |12/44.13     10/46.13     5/42.40      6/43.85      | 
|POLY-3 PERCENT (g) |     13.2%        8.4%         10.6%        15.6%       |27.2%        21.7%        11.8%        13.7%        | 
|TERMINAL (d)       |     4/38 (11%)   3/41 (7%)    3/41 (7%)    3/33 (9%)   |11/36 (31%)  7/35 (20%)   4/31 (13%)   5/35 (14%)   | 
|FIRST INCIDENCE    |     562          698          543          595         |576          568          712          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.281      P=0.323N     P=0.453N     P=0.442     |P=0.063N     P=0.426N     P=0.097N     P=0.107N     | 
|POLY 3             |     P=0.335      P=0.344N     P=0.473N     P=0.491     |P=0.053N     P=0.358N     P=0.060N     P=0.094N     | 
|POLY 1.5           |     P=0.342      P=0.353N     P=0.481N     P=0.495     |P=0.053N     P=0.375N     P=0.061N     P=0.096N     | 
|POLY 6             |     P=0.326      P=0.332N     P=0.465N     P=0.485     |P=0.054N     P=0.334N     P=0.061N     P=0.090N     | 
|LOGISTIC REGRESSION|     P=0.366      P=0.375N     P=0.543N     P=0.504     |P=0.054N     P=0.365N     P=0.060N     P=0.095N     | 
|COCH-ARM / FISHERS |     P=0.351      P=0.370N     P=0.500N     P=0.500     |P=0.050N     P=0.405N     P=0.054N     P=0.096N     | 
|ORDER RESTRICTED   |     P=0.383      (e)          (e)          (e)         |P=0.059N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Duodenum                                                                                                        | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      2/46.48      0/43.80     |0/43.63      0/45.35      0/42.33      1/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         0.0%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    2/41 (5%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.566      (e)          P=0.255      (e)         |P=0.199      (e)          (e)          P=0.494      | 
|POLY 3             |     P=0.573      (e)          P=0.246      (e)         |P=0.196      (e)          (e)          P=0.499      | 
|POLY 1.5           |     P=0.582      (e)          P=0.243      (e)         |P=0.196      (e)          (e)          P=0.498      | 
|POLY 6             |     P=0.558      (e)          P=0.250      (e)         |P=0.196      (e)          (e)          P=0.500      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.255      (e)         |(e)          (e)          (e)          P=0.494      | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.255      (e)          (e)          (e)         |P=0.119      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Jejunum                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/44.60      2/47.28      0/46.48      2/44.39     |0/43.63      0/45.35      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     4.5%         4.2%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    2/41 (5%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          570         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.599N     P=0.667N     P=0.222N     P=0.666     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.557N     P=0.673N     P=0.228N     P=0.692     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.556N     P=0.681N     P=0.231N     P=0.693     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.559N     P=0.663N     P=0.225N     P=0.690     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.555N     P=0.667N     (e)          P=0.694N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.691N     P=0.247N     P=0.691N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.437N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/44.60      2/47.28      0/46.48      3/44.39     |0/43.63      0/45.35      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     4.5%         4.2%         0.0%         6.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    2/41 (5%)    0/41 (0%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          570         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.373      P=0.667N     P=0.222N     P=0.461     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.418      P=0.673N     P=0.228N     P=0.498     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.420      P=0.681N     P=0.231N     P=0.499     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.414      P=0.663N     P=0.225N     P=0.495     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.420      P=0.667N     (e)          P=0.499     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.423      P=0.691N     P=0.247N     P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.277      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    1/50 (2%)    4/50 (8%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/44.60      2/47.28      1/46.48      4/44.39     |0/43.63      1/45.45      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     6.7%         4.2%         2.2%         9.0%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/38 (8%)    2/41 (5%)    1/41 (2%)    2/33 (6%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      570         |---          706          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309      P=0.465N     P=0.278N     P=0.445     |P=0.582N     P=0.520      (e)          (e)          | 
|POLY 3             |     P=0.362      P=0.473N     P=0.291N     P=0.497     |P=0.565N     P=0.508      (e)          (e)          | 
|POLY 1.5           |     P=0.366      P=0.484N     P=0.296N     P=0.499     |P=0.567N     P=0.505      (e)          (e)          | 
|POLY 6             |     P=0.356      P=0.461N     P=0.286N     P=0.494     |P=0.563N     P=0.512      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.358      P=0.465N     P=0.278N     P=0.494     |P=0.570N     P=0.505      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.371      P=0.500N     P=0.309N     P=0.500     |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.270      (e)          (e)          (e)         |P=0.389N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Polyp Adenomatous                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      2/46.48      0/43.80     |0/43.63      0/45.35      0/42.33      1/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         0.0%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    2/41 (5%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.566      (e)          P=0.255      (e)         |P=0.199      (e)          (e)          P=0.494      | 
|POLY 3             |     P=0.573      (e)          P=0.246      (e)         |P=0.196      (e)          (e)          P=0.499      | 
|POLY 1.5           |     P=0.582      (e)          P=0.243      (e)         |P=0.196      (e)          (e)          P=0.498      | 
|POLY 6             |     P=0.558      (e)          P=0.250      (e)         |P=0.196      (e)          (e)          P=0.500      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.255      (e)         |(e)          (e)          (e)          P=0.494      | 
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.255      (e)          (e)          (e)         |P=0.119      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/46 (0%)    2/47 (4%)    2/49 (4%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     1/43.91      0/47.28      0/46.48      1/43.84     |0/42.28      2/44.36      2/42.00      3/43.88      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         2.3%        |0.0%         4.5%         4.8%         6.8%         | 
|TERMINAL (d)       |     1/38 (3%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    1/35 (3%)    2/31 (7%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          719         |---          706          729 (T)      475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570      P=0.485N     P=0.485N     P=0.735     |P=0.106      P=0.248      P=0.206      P=0.126      | 
|POLY 3             |     P=0.591      P=0.485N     P=0.489N     P=0.760     |P=0.112      P=0.248      P=0.235      P=0.125      | 
|POLY 1.5           |     P=0.595      P=0.488N     P=0.490N     P=0.758N    |P=0.113      P=0.245      P=0.238      P=0.125      | 
|POLY 6             |     P=0.585      P=0.481N     P=0.487N     P=0.756     |P=0.112      P=0.252      P=0.232      P=0.126      | 
|LOGISTIC REGRESSION|     P=0.583      (e)          (e)          P=0.752     |P=0.127      P=0.248      P=0.206      P=0.171      | 
|COCH-ARM / FISHERS |     P=0.602      P=0.490N     P=0.490N     P=0.742N    |P=0.121      P=0.253      P=0.263      P=0.133      | 
|ORDER RESTRICTED   |     P=0.393      (e)          (e)          (e)         |P=0.082      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/46 (0%)    2/47 (4%)    2/49 (4%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |     1/43.91      0/47.28      0/46.48      2/43.84     |0/42.28      2/44.36      2/42.00      4/43.88      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         4.6%        |0.0%         4.5%         4.8%         9.1%         | 
|TERMINAL (d)       |     1/38 (3%)    0/41 (0%)    0/41 (0%)    1/33 (3%)   |0/36 (0%)    1/35 (3%)    2/31 (7%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          719         |---          706          729 (T)      475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.210      P=0.485N     P=0.485N     P=0.458     |P=0.043 *    P=0.248      P=0.206      P=0.066      | 
|POLY 3             |     P=0.243      P=0.485N     P=0.489N     P=0.499     |P=0.045 *    P=0.248      P=0.235      P=0.065      | 
|POLY 1.5           |     P=0.246      P=0.488N     P=0.490N     P=0.505     |P=0.046 *    P=0.245      P=0.238      P=0.065      | 
|POLY 6             |     P=0.238      P=0.481N     P=0.487N     P=0.492     |P=0.045 *    P=0.252      P=0.232      P=0.065      | 
|LOGISTIC REGRESSION|     P=0.222      (e)          (e)          P=0.479     |P=0.052      P=0.248      P=0.206      P=0.087      | 
|COCH-ARM / FISHERS |     P=0.252      P=0.490N     P=0.490N     P=0.515     |P=0.051      P=0.253      P=0.263      P=0.067      | 
|ORDER RESTRICTED   |     P=0.128      (e)          (e)          (e)         |P=0.030 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/49 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.91      0/47.28      1/46.48      0/43.80     |2/43.57      0/45.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |4.6%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    1/41 (2%)    0/33 (0%)   |2/36 (6%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.681      (e)          P=0.515      (e)         |P=0.123N     P=0.244N     P=0.272N     P=0.244N     | 
|POLY 3             |     P=0.675      (e)          P=0.511      (e)         |P=0.114N     P=0.228N     P=0.245N     P=0.238N     | 
|POLY 1.5           |     P=0.684      (e)          P=0.510      (e)         |P=0.114N     P=0.231N     P=0.246N     P=0.238N     | 
|POLY 6             |     P=0.662      (e)          P=0.513      (e)         |P=0.116N     P=0.224N     P=0.245N     P=0.237N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.515      (e)         |P=0.123N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.699      (e)          P=0.510      (e)         |P=0.114N     P=0.242N     P=0.247N     P=0.242N     | 
|ORDER RESTRICTED   |     P=0.391      (e)          (e)          (e)         |P=0.030N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |1/49 (2%)    2/50 (4%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.91      2/47.28      1/46.48      2/43.80     |1/43.57      2/45.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     2.3%         4.2%         2.2%         4.6%        |2.3%         4.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    2/41 (5%)    1/41 (2%)    2/33 (6%)   |1/36 (3%)    2/35 (6%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.385      P=0.527      P=0.745N     P=0.451     |P=0.198N     P=0.490      P=0.530N     P=0.506N     | 
|POLY 3             |     P=0.437      P=0.526      P=0.748N     P=0.499     |P=0.190N     P=0.514      P=0.507N     P=0.501N     | 
|POLY 1.5           |     P=0.444      P=0.520      P=0.749N     P=0.505     |P=0.190N     P=0.510      P=0.508N     P=0.501N     | 
|POLY 6             |     P=0.428      P=0.533      P=0.746N     P=0.492     |P=0.189N     P=0.520      P=0.507N     P=0.500N     | 
|LOGISTIC REGRESSION|     P=0.385      P=0.527      P=0.745N     P=0.451     |P=0.198N     P=0.490      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.456      P=0.515      P=0.742N     P=0.515     |P=0.186N     P=0.508      P=0.500N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.442      (e)          (e)          (e)         |P=0.175N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatoblastoma                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/48 (13%)   3/50 (6%)    1/50 (2%)    3/50 (6%)   |1/49 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     6/44.45      3/47.85      1/46.71      3/43.84     |1/43.57      0/45.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     13.5%        6.3%         2.1%         6.8%        |2.3%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     5/38 (13%)   1/41 (2%)    0/41 (0%)    2/33 (6%)   |1/36 (3%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     561          577          668          719         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.222N     P=0.212N     P=0.051N     P=0.307N    |P=0.313N     P=0.506N     P=0.530N     P=0.506N     | 
|POLY 3             |     P=0.179N     P=0.207N     P=0.048N*    P=0.248N    |P=0.306N     P=0.492N     P=0.507N     P=0.501N     | 
|POLY 1.5           |     P=0.174N     P=0.214N     P=0.049N*    P=0.239N    |P=0.305N     P=0.494N     P=0.508N     P=0.501N     | 
|POLY 6             |     P=0.186N     P=0.197N     P=0.047N*    P=0.261N    |P=0.308N     P=0.489N     P=0.507N     P=0.500N     | 
|LOGISTIC REGRESSION|     P=0.158N     P=0.238N     P=0.054N     P=0.239N    |P=0.313N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.166N     P=0.223N     P=0.050N     P=0.223N    |P=0.304N     P=0.495N     P=0.500N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.076N     (e)          (e)          (e)         |P=0.121N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     30/48 (63%)  32/50 (64%)  36/50 (72%)  30/50 (60%) |30/49 (61%)  19/50 (38%)  26/49 (53%)  23/50 (46%)  | 
|POLY-3 RATE (b)    |     30/46.51     32/47.31     36/48.04     30/45.77    |30/45.42     19/45.74     26/43.41     23/44.75     | 
|POLY-3 PERCENT (g) |     64.5%        67.6%        74.9%        65.5%       |66.1%        41.5%        59.9%        51.4%        | 
|TERMINAL (d)       |     25/38 (66%)  31/41 (76%)  32/41 (78%)  24/33 (73%) |26/36 (72%)  17/35 (49%)  19/31 (61%)  20/35 (57%)  | 
|FIRST INCIDENCE    |     484          722          543          535         |524          674          602          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.185      P=0.563N     P=0.300      P=0.310     |P=0.289N     P=0.023N*    P=0.537N     P=0.132N     | 
|POLY 3             |     P=0.478      P=0.459      P=0.184      P=0.546     |P=0.252N     P=0.013N*    P=0.348N     P=0.108N     | 
|POLY 1.5           |     P=0.533      P=0.482      P=0.197      P=0.577N    |P=0.248N     P=0.014N*    P=0.350N     P=0.108N     | 
|POLY 6             |     P=0.417      P=0.438      P=0.172      P=0.492     |P=0.252N     P=0.011N*    P=0.339N     P=0.104N     | 
|LOGISTIC REGRESSION|     P=0.500      P=0.584N     P=0.228      P=0.549N    |P=0.263N     P=0.010N*    P=0.331N     P=0.108N     | 
|COCH-ARM / FISHERS |     P=0.449N     P=0.522      P=0.216      P=0.482N    |P=0.214N     P=0.017N*    P=0.270N     P=0.094N     | 
|ORDER RESTRICTED   |     P=0.427      (e)          (e)          (e)         |P=0.100N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     20/48 (42%)  14/50 (28%)  19/50 (38%)  13/50 (26%) |3/49 (6%)    13/50 (26%)  15/49 (31%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     20/46.21     14/48.93     19/48.53     13/45.80    |3/43.65      13/45.65     15/42.18     9/44.29      | 
|POLY-3 PERCENT (g) |     43.3%        28.6%        39.2%        28.4%       |6.9%         28.5%        35.6%        20.3%        | 
|TERMINAL (d)       |     14/38 (37%)  10/41 (24%)  14/41 (34%)  5/33 (15%)  |2/36 (6%)    9/35 (26%)   12/31 (39%)  7/35 (20%)   | 
|FIRST INCIDENCE    |     484          431          558          570         |710          682          711          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.276N     P=0.110N     P=0.400N     P=0.200N    |P=0.154      P=0.009 **   P<0.001 **   P=0.060      | 
|POLY 3             |     P=0.159N     P=0.099N     P=0.421N     P=0.100N    |P=0.158      P=0.007 **   P<0.001 **   P=0.061      | 
|POLY 1.5           |     P=0.144N     P=0.105N     P=0.427N     P=0.091N    |P=0.157      P=0.007 **   P<0.001 **   P=0.061      | 
|POLY 6             |     P=0.176N     P=0.093N     P=0.416N     P=0.109N    |P=0.164      P=0.008 **   P<0.001 **   P=0.063      | 
|LOGISTIC REGRESSION|     P=0.084N     P=0.142N     P=0.462N     P=0.068N    |P=0.150      P=0.009 **   P<0.001 **   P=0.062      | 
|COCH-ARM / FISHERS |     P=0.117N     P=0.113N     P=0.435N     P=0.077N    |P=0.179      P=0.007 **   P=0.002 **   P=0.065      | 
|ORDER RESTRICTED   |     P=0.104N     (e)          (e)          (e)         |P=0.010 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/48 (48%)  16/50 (32%)  20/50 (40%)  16/50 (32%) |4/49 (8%)    13/50 (26%)  15/49 (31%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     23/46.76     16/49.00     20/48.76     16/45.84    |4/43.65      13/45.65     15/42.18     9/44.29      | 
|POLY-3 PERCENT (g) |     49.2%        32.7%        41.0%        34.9%       |9.2%         28.5%        35.6%        20.3%        | 
|TERMINAL (d)       |     16/38 (42%)  11/41 (27%)  14/41 (34%)  7/33 (21%)  |3/36 (8%)    9/35 (26%)   12/31 (39%)  7/35 (20%)   | 
|FIRST INCIDENCE    |     484          431          558          570         |710          682          711          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.313N     P=0.084N     P=0.267N     P=0.232N    |P=0.208      P=0.020 *    P=0.002 **   P=0.112      | 
|POLY 3             |     P=0.180N     P=0.074N     P=0.276N     P=0.117N    |P=0.219      P=0.018 *    P=0.002 **   P=0.119      | 
|POLY 1.5           |     P=0.160N     P=0.076N     P=0.278N     P=0.102N    |P=0.217      P=0.017 *    P=0.003 **   P=0.118      | 
|POLY 6             |     P=0.203N     P=0.070N     P=0.272N     P=0.133N    |P=0.226      P=0.020 *    P=0.002 **   P=0.123      | 
|LOGISTIC REGRESSION|     P=0.091N     P=0.106N     P=0.306N     P=0.073N    |P=0.207      P=0.022 *    P=0.003 **   P=0.116      | 
|COCH-ARM / FISHERS |     P=0.125N     P=0.080N     P=0.279N     P=0.080N    |P=0.241      P=0.017 *    P=0.005 **   P=0.125      | 
|ORDER RESTRICTED   |     P=0.126N     (e)          (e)          (e)         |P=0.022 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/48 (85%)  42/50 (84%)  44/50 (88%)  40/50 (80%) |31/49 (63%)  26/50 (52%)  31/49 (63%)  26/50 (52%)  | 
|POLY-3 RATE (b)    |     41/47.67     42/48.96     44/49.35     40/47.50    |31/45.50     26/45.86     31/43.48     26/44.92     | 
|POLY-3 PERCENT (g) |     86.0%        85.8%        89.2%        84.2%       |68.1%        56.7%        71.3%        57.9%        | 
|TERMINAL (d)       |     32/38 (84%)  37/41 (90%)  37/41 (90%)  27/33 (82%) |26/36 (72%)  21/35 (60%)  23/31 (74%)  22/35 (63%)  | 
|FIRST INCIDENCE    |     484          431          543          535         |524          674          602          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.197      P=0.404N     P=0.576N     P=0.333     |P=0.340N     P=0.239N     P=0.292      P=0.249N     | 
|POLY 3             |     P=0.477N     P=0.604N     P=0.434      P=0.517N    |P=0.287N     P=0.174N     P=0.461      P=0.207N     | 
|POLY 1.5           |     P=0.416N     P=0.574N     P=0.450      P=0.455N    |P=0.283N     P=0.176N     P=0.467      P=0.206N     | 
|POLY 6             |     P=0.525N     P=0.597      P=0.411      P=0.571N    |P=0.286N     P=0.164N     P=0.464      P=0.202N     | 
|LOGISTIC REGRESSION|     P=0.371N     P=0.523N     P=0.466      P=0.394N    |P=0.297N     P=0.123N     P=0.493      P=0.204N     | 
|COCH-ARM / FISHERS |     P=0.289N     P=0.535N     P=0.468      P=0.330N    |P=0.237N     P=0.176N     P=0.583N     P=0.176N     | 
|ORDER RESTRICTED   |     P=0.539N     (e)          (e)          (e)         |P=0.233N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/48 (85%)  43/50 (86%)  45/50 (90%)  40/50 (80%) |31/49 (63%)  26/50 (52%)  31/49 (63%)  26/50 (52%)  | 
|POLY-3 RATE (b)    |     41/47.67     43/49.02     45/49.58     40/47.50    |31/45.50     26/45.86     31/43.48     26/44.92     | 
|POLY-3 PERCENT (g) |     86.0%        87.7%        90.8%        84.2%       |68.1%        56.7%        71.3%        57.9%        | 
|TERMINAL (d)       |     32/38 (84%)  37/41 (90%)  37/41 (90%)  27/33 (82%) |26/36 (72%)  21/35 (60%)  23/31 (74%)  22/35 (63%)  | 
|FIRST INCIDENCE    |     484          431          543          535         |524          674          602          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.212      P=0.481N     P=0.508      P=0.333     |P=0.340N     P=0.239N     P=0.292      P=0.249N     | 
|POLY 3             |     P=0.448N     P=0.522      P=0.337      P=0.517N    |P=0.287N     P=0.174N     P=0.461      P=0.207N     | 
|POLY 1.5           |     P=0.387N     P=0.547      P=0.342      P=0.455N    |P=0.283N     P=0.176N     P=0.467      P=0.206N     | 
|POLY 6             |     P=0.498N     P=0.490      P=0.332      P=0.571N    |P=0.286N     P=0.164N     P=0.464      P=0.202N     | 
|LOGISTIC REGRESSION|     P=0.338N     P=0.594      P=0.344      P=0.394N    |P=0.297N     P=0.123N     P=0.493      P=0.204N     | 
|COCH-ARM / FISHERS |     P=0.259N     P=0.581      P=0.351      P=0.330N    |P=0.237N     P=0.176N     P=0.583N     P=0.176N     | 
|ORDER RESTRICTED   |     P=0.440N     (e)          (e)          (e)         |P=0.233N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    7/50 (14%)   6/50 (12%)  |3/50 (6%)    1/50 (2%)    0/49 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     6/44.60      4/47.71      7/47.00      6/43.91     |3/43.98      1/45.35      0/41.33      3/43.40      | 
|POLY-3 PERCENT (g) |     13.5%        8.4%         14.9%        13.7%       |6.8%         2.2%         0.0%         6.9%         | 
|TERMINAL (d)       |     6/38 (16%)   3/41 (7%)    6/41 (15%)   4/33 (12%)  |2/36 (6%)    1/35 (3%)    0/30 (0%)    3/35 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      604          570          711         |630          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.354      P=0.324N     P=0.556      P=0.528     |P=0.512      P=0.308N     P=0.148N     P=0.653      | 
|POLY 3             |     P=0.423      P=0.328N     P=0.540      P=0.610     |P=0.513      P=0.294N     P=0.130N     P=0.657      | 
|POLY 1.5           |     P=0.437      P=0.344N     P=0.526      P=0.615     |P=0.515      P=0.298N     P=0.129N     P=0.657      | 
|POLY 6             |     P=0.403      P=0.308N     P=0.556      P=0.602     |P=0.509      P=0.290N     P=0.132N     P=0.657      | 
|LOGISTIC REGRESSION|     P=0.427      P=0.333N     P=0.535      P=0.573     |P=0.516      P=0.296N     P=0.128N     P=0.662      | 
|COCH-ARM / FISHERS |     P=0.455      P=0.370N     P=0.500      P=0.620N    |P=0.525      P=0.309N     P=0.125N     P=0.661N     | 
|ORDER RESTRICTED   |     P=0.496      (e)          (e)          (e)         |P=0.284      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   7/50 (14%)   4/50 (8%)   |1/50 (2%)    1/50 (2%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/45.19      5/47.28      7/47.72      4/44.15     |1/43.63      1/45.35      2/41.40      1/43.40      | 
|POLY-3 PERCENT (g) |     8.9%         10.6%        14.7%        9.1%        |2.3%         2.2%         4.8%         2.3%         | 
|TERMINAL (d)       |     2/38 (5%)    5/41 (12%)   4/41 (10%)   2/33 (6%)   |1/36 (3%)    1/35 (3%)    1/30 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     638          729 (T)      543          640         |729 (T)      729 (T)      712          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.481      P=0.550      P=0.314      P=0.590     |P=0.575      P=0.756      P=0.455      P=0.756      | 
|POLY 3             |     P=0.534      P=0.528      P=0.293      P=0.631     |P=0.581      P=0.752N     P=0.482      P=0.760      | 
|POLY 1.5           |     P=0.547      P=0.518      P=0.282      P=0.636     |P=0.582      P=0.755N     P=0.482      P=0.759      | 
|POLY 6             |     P=0.516      P=0.539      P=0.305      P=0.621     |P=0.581      P=0.748N     P=0.481      P=0.761N     | 
|LOGISTIC REGRESSION|     P=0.559N     P=0.522      P=0.219      P=0.641     |P=0.580      P=0.756      P=0.477      P=0.756      | 
|COCH-ARM / FISHERS |     P=0.563      P=0.500      P=0.262      P=0.643N    |P=0.590      P=0.753N     P=0.492      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.505      (e)          (e)          (e)         |P=0.563      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  8/50 (16%)   13/50 (26%)  9/50 (18%)  |4/50 (8%)    2/50 (4%)    2/49 (4%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     10/45.19     8/47.71      13/48.25     9/44.27     |4/43.98      2/45.35      2/41.40      4/43.40      | 
|POLY-3 PERCENT (g) |     22.1%        16.8%        27.0%        20.3%       |9.1%         4.4%         4.8%         9.2%         | 
|TERMINAL (d)       |     8/38 (21%)   7/41 (17%)   9/41 (22%)   5/33 (15%)  |3/36 (8%)    2/35 (6%)    1/30 (3%)    4/35 (11%)   | 
|FIRST INCIDENCE    |     638          604          543          640         |630          729 (T)      712          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.418      P=0.331N     P=0.398      P=0.590     |P=0.479      P=0.343N     P=0.402N     P=0.631      | 
|POLY 3             |     P=0.505      P=0.349N     P=0.383      P=0.520N    |P=0.482      P=0.323N     P=0.365N     P=0.636      | 
|POLY 1.5           |     P=0.523      P=0.367N     P=0.359      P=0.511N    |P=0.486      P=0.328N     P=0.363N     P=0.637      | 
|POLY 6             |     P=0.480      P=0.328N     P=0.408      P=0.536N    |P=0.478      P=0.317N     P=0.369N     P=0.636      | 
|LOGISTIC REGRESSION|     P=0.537      P=0.358N     P=0.310      P=0.524N    |P=0.486      P=0.318N     P=0.362N     P=0.644      | 
|COCH-ARM / FISHERS |     P=0.548      P=0.398N     P=0.318      P=0.500N    |P=0.499      P=0.339N     P=0.349N     P=0.643N     | 
|ORDER RESTRICTED   |     P=0.488      (e)          (e)          (e)         |P=0.449      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Choriocarcinoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/45 (0%)    0/45 (0%)    2/47 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/39.57      0/41.72      2/40.43      0/43.40      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         5.0%         0.0%         | 
|TERMINAL (d)       |                                                        |0/32 (0%)    0/34 (0%)    1/30 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          683          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.602      (e)          P=0.233      (e)          | 
|POLY 3             |                                                        |P=0.604      (e)          P=0.241      (e)          | 
|POLY 1.5           |                                                        |P=0.606      (e)          P=0.240      (e)          | 
|POLY 6             |                                                        |P=0.604      (e)          P=0.244      (e)          | 
|LOGISTIC REGRESSION|                                                        |P=0.612      (e)          P=0.241      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.617      (e)          P=0.258      (e)          | 
|ORDER RESTRICTED   |                                                        |P=0.252      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/45 (2%)    4/45 (9%)    1/47 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |1/39.57      4/41.90      1/40.25      1/43.40      | 
|POLY-3 PERCENT (g) |                                                        |2.5%         9.6%         2.5%         2.3%         | 
|TERMINAL (d)       |                                                        |1/32 (3%)    3/34 (9%)    1/30 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      682          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.353N     P=0.204      P=0.748      P=0.742N     | 
|POLY 3             |                                                        |P=0.336N     P=0.196      P=0.757N     P=0.740N     | 
|POLY 1.5           |                                                        |P=0.338N     P=0.188      P=0.758N     P=0.741N     | 
|POLY 6             |                                                        |P=0.330N     P=0.208      P=0.755N     P=0.738N     | 
|LOGISTIC REGRESSION|                                                        |P=0.343N     P=0.204      P=0.748      P=0.742N     | 
|COCH-ARM / FISHERS |                                                        |P=0.332N     P=0.180      P=0.742N     P=0.726N     | 
|ORDER RESTRICTED   |                                                        |P=0.305N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Granulosa Cell Tumor Benign                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/45 (2%)    1/45 (2%)    1/47 (2%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |                                                        |1/39.57      1/41.72      1/40.25      5/43.40      | 
|POLY-3 PERCENT (g) |                                                        |2.5%         2.4%         2.5%         11.5%        | 
|TERMINAL (d)       |                                                        |1/32 (3%)    1/34 (3%)    1/30 (3%)    5/35 (14%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.031 *    P=0.748N     P=0.748      P=0.123      | 
|POLY 3             |                                                        |P=0.031 *    P=0.749N     P=0.757N     P=0.123      | 
|POLY 1.5           |                                                        |P=0.032 *    P=0.754N     P=0.758N     P=0.122      | 
|POLY 6             |                                                        |P=0.030 *    P=0.741N     P=0.755N     P=0.125      | 
|LOGISTIC REGRESSION|                                                        |P=0.031 *    P=0.748N     P=0.748      P=0.123      | 
|COCH-ARM / FISHERS |                                                        |P=0.035 *    P=0.753N     P=0.742N     P=0.128      | 
|ORDER RESTRICTED   |                                                        |P=0.036 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Granulosa Cell Tumor: Benign, Malignant, NOS                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/45 (2%)    1/45 (2%)    1/47 (2%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |                                                        |1/39.57      1/41.72      1/40.25      6/44.39      | 
|POLY-3 PERCENT (g) |                                                        |2.5%         2.4%         2.5%         13.5%        | 
|TERMINAL (d)       |                                                        |1/32 (3%)    1/34 (3%)    1/30 (3%)    5/35 (14%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.012 *    P=0.748N     P=0.748      P=0.073      | 
|POLY 3             |                                                        |P=0.012 *    P=0.749N     P=0.757N     P=0.075      | 
|POLY 1.5           |                                                        |P=0.012 *    P=0.754N     P=0.758N     P=0.075      | 
|POLY 6             |                                                        |P=0.011 *    P=0.741N     P=0.755N     P=0.077      | 
|LOGISTIC REGRESSION|                                                        |P=0.015 *    P=0.748N     P=0.748      P=0.089      | 
|COCH-ARM / FISHERS |                                                        |P=0.013 *    P=0.753N     P=0.742N     P=0.074      | 
|ORDER RESTRICTED   |                                                        |P=0.015 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Luteoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/45 (7%)    0/45 (0%)    1/47 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |3/39.78      0/41.72      1/40.25      0/43.40      | 
|POLY-3 PERCENT (g) |                                                        |7.5%         0.0%         2.5%         0.0%         | 
|TERMINAL (d)       |                                                        |2/32 (6%)    0/34 (0%)    1/30 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |                                                        |674          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.084N     P=0.109N     P=0.326N     P=0.110N     | 
|POLY 3             |                                                        |P=0.079N     P=0.110N     P=0.300N     P=0.103N     | 
|POLY 1.5           |                                                        |P=0.078N     P=0.114N     P=0.302N     P=0.103N     | 
|POLY 6             |                                                        |P=0.082N     P=0.105N     P=0.298N     P=0.101N     | 
|LOGISTIC REGRESSION|                                                        |P=0.078N     P=0.111N     P=0.295N     P=0.104N     | 
|COCH-ARM / FISHERS |                                                        |P=0.075N     P=0.121N     P=0.292N     P=0.103N     | 
|ORDER RESTRICTED   |                                                        |P=0.016N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    1/47 (2%)    0/45 (0%)    0/49 (0%)   |3/46 (7%)    2/45 (4%)    4/48 (8%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/42.10      1/44.28      0/42.54      0/42.80     |3/41.52      2/41.26      4/40.71      4/43.56      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         0.0%        |7.2%         4.9%         9.8%         9.2%         | 
|TERMINAL (d)       |     0/37 (0%)    1/38 (3%)    0/38 (0%)    0/32 (0%)   |3/35 (9%)    2/32 (6%)    4/30 (13%)   3/35 (9%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |729 (T)      729 (T)      729 (T)      688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.591N     P=0.505      (e)          (e)         |P=0.339      P=0.541N     P=0.415      P=0.500      | 
|POLY 3             |     P=0.553N     P=0.510      (e)          (e)         |P=0.356      P=0.503N     P=0.489      P=0.526      | 
|POLY 1.5           |     P=0.556N     P=0.506      (e)          (e)         |P=0.362      P=0.506N     P=0.494      P=0.530      | 
|POLY 6             |     P=0.550N     P=0.514      (e)          (e)         |P=0.352      P=0.497N     P=0.484      P=0.526      | 
|LOGISTIC REGRESSION|     (e)          P=0.505      (e)          (e)         |P=0.340      P=0.541N     P=0.415      P=0.520      | 
|COCH-ARM / FISHERS |     P=0.561N     P=0.500      (e)          (e)         |P=0.383      P=0.511N     P=0.524      P=0.547      | 
|ORDER RESTRICTED   |     P=0.387N     (e)          (e)          (e)         |P=0.436      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skeletal Muscle                                                                                                                  | 
|     Rhabdomyosarcoma                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      1/44.40     |0/43.63      1/46.10      1/42.33      2/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |0.0%         2.2%         2.4%         4.6%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    1/31 (3%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          535         |---          461          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.197      (e)          (e)          P=0.500     |P=0.150      P=0.508      P=0.470      P=0.232      | 
|POLY 3             |     P=0.195      (e)          (e)          P=0.499     |P=0.149      P=0.511      P=0.494      P=0.236      | 
|POLY 1.5           |     P=0.197      (e)          (e)          P=0.500     |P=0.150      P=0.507      P=0.494      P=0.235      | 
|POLY 6             |     P=0.192      (e)          (e)          P=0.498     |P=0.149      P=0.516      P=0.493      P=0.237      | 
|LOGISTIC REGRESSION|     P=0.246      (e)          (e)          P=0.513     |P=0.156      P=0.312      P=0.470      P=0.232      | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.153      P=0.500      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     P=0.119      (e)          (e)          (e)         |P=0.116      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      1/46.48      0/43.80     |0/43.63      1/46.01      0/42.33      3/43.50      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |0.0%         2.2%         0.0%         6.9%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    1/41 (2%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          513          ---          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.681      (e)          P=0.515      (e)         |P=0.043 *    P=0.500      (e)          P=0.118      | 
|POLY 3             |     P=0.677      (e)          P=0.508      (e)         |P=0.041 *    P=0.511      (e)          P=0.118      | 
|POLY 1.5           |     P=0.684      (e)          P=0.506      (e)         |P=0.042 *    P=0.507      (e)          P=0.117      | 
|POLY 6             |     P=0.666      (e)          P=0.511      (e)         |P=0.041 *    P=0.515      (e)          P=0.119      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.515      (e)         |P=0.045 *    P=0.371      (e)          P=0.120      | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.044 *    P=0.500      (e)          P=0.121      | 
|ORDER RESTRICTED   |     P=0.389      (e)          (e)          (e)         |P=0.020 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |0/43.63      1/46.01      0/42.33      2/43.50      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          513          ---          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.135      P=0.500      (e)          P=0.234      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.137      P=0.511      (e)          P=0.236      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.137      P=0.507      (e)          P=0.236      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.138      P=0.515      (e)          P=0.238      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.144      P=0.371      (e)          P=0.237      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.140      P=0.500      (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.074      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      1/46.48      0/43.80     |0/43.63      1/46.01      0/42.33      3/43.50      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |0.0%         2.2%         0.0%         6.9%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    1/41 (2%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          513          ---          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.681      (e)          P=0.515      (e)         |P=0.043 *    P=0.500      (e)          P=0.118      | 
|POLY 3             |     P=0.677      (e)          P=0.508      (e)         |P=0.041 *    P=0.511      (e)          P=0.118      | 
|POLY 1.5           |     P=0.684      (e)          P=0.506      (e)         |P=0.042 *    P=0.507      (e)          P=0.117      | 
|POLY 6             |     P=0.666      (e)          P=0.511      (e)         |P=0.041 *    P=0.515      (e)          P=0.119      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.515      (e)         |P=0.045 *    P=0.371      (e)          P=0.120      | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.044 *    P=0.500      (e)          P=0.121      | 
|ORDER RESTRICTED   |     P=0.389      (e)          (e)          (e)         |P=0.020 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Schwannoma Malignant                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |3/44.09      1/45.90      0/42.33      1/43.57      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.8%         2.2%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |2/36 (6%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |591          561          ---          685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.211N     P=0.317N     P=0.144N     P=0.310N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.207N     P=0.291N     P=0.126N     P=0.309N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.206N     P=0.296N     P=0.125N     P=0.309N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.210N     P=0.285N     P=0.127N     P=0.308N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.192N     P=0.337N     P=0.121N     P=0.305N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.200N     P=0.309N     P=0.121N     P=0.309N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.085N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/49 (4%)    1/48 (2%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.91      0/47.28      1/46.72      0/43.80     |2/44.00      1/44.82      1/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.1%         0.0%        |4.6%         2.2%         2.4%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |1/36 (3%)    0/35 (0%)    1/31 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          667          ---         |606          674          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.690      (e)          P=0.529      (e)         |P=0.159N     P=0.484N     P=0.535N     P=0.240N     | 
|POLY 3             |     P=0.675      (e)          P=0.512      (e)         |P=0.159N     P=0.494N     P=0.516N     P=0.240N     | 
|POLY 1.5           |     P=0.684      (e)          P=0.511      (e)         |P=0.157N     P=0.500N     P=0.515N     P=0.239N     | 
|POLY 6             |     P=0.662      (e)          P=0.515      (e)         |P=0.161N     P=0.485N     P=0.518N     P=0.240N     | 
|LOGISTIC REGRESSION|     P=0.721      (e)          P=0.492      (e)         |P=0.147N     P=0.535N     P=0.504N     P=0.221N     | 
|COCH-ARM / FISHERS |     P=0.699      (e)          P=0.510      (e)         |P=0.149N     P=0.508N     P=0.500N     P=0.242N     | 
|ORDER RESTRICTED   |     P=0.392      (e)          (e)          (e)         |P=0.120N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      2/46.48      2/44.19     |0/43.63      1/45.35      3/42.84      1/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         4.5%        |0.0%         2.2%         7.0%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    2/41 (5%)    1/33 (3%)   |0/36 (0%)    1/35 (3%)    2/31 (7%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      618         |---          729 (T)      574          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.067      (e)          P=0.255      P=0.222     |P=0.341      P=0.494      P=0.102      P=0.494      | 
|POLY 3             |     P=0.080      (e)          P=0.246      P=0.235     |P=0.343      P=0.508      P=0.115      P=0.499      | 
|POLY 1.5           |     P=0.082      (e)          P=0.243      P=0.236     |P=0.344      P=0.505      P=0.114      P=0.498      | 
|POLY 6             |     P=0.076      (e)          P=0.250      P=0.233     |P=0.344      P=0.511      P=0.116      P=0.500      | 
|LOGISTIC REGRESSION|     P=0.085      (e)          P=0.255      P=0.240     |P=0.347      P=0.494      P=0.120      P=0.494      | 
|COCH-ARM / FISHERS |     P=0.086      (e)          P=0.247      P=0.247     |P=0.351      P=0.500      P=0.121      P=0.500      | 
|ORDER RESTRICTED   |     P=0.114      (e)          (e)          (e)         |P=0.150      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      2/46.48      2/44.19     |0/43.63      0/45.35      2/42.84      1/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.3%         4.5%        |0.0%         0.0%         4.7%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    2/41 (5%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    1/31 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      618         |---          ---          574          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.067      (e)          P=0.255      P=0.222     |P=0.241      (e)          P=0.216      P=0.494      | 
|POLY 3             |     P=0.080      (e)          P=0.246      P=0.235     |P=0.239      (e)          P=0.233      P=0.499      | 
|POLY 1.5           |     P=0.082      (e)          P=0.243      P=0.236     |P=0.240      (e)          P=0.232      P=0.498      | 
|POLY 6             |     P=0.076      (e)          P=0.250      P=0.233     |P=0.239      (e)          P=0.234      P=0.500      | 
|LOGISTIC REGRESSION|     P=0.085      (e)          P=0.255      P=0.240     |P=0.247      (e)          P=0.244      P=0.494      | 
|COCH-ARM / FISHERS |     P=0.086      (e)          P=0.247      P=0.247     |P=0.246      (e)          P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.114      (e)          (e)          (e)         |P=0.164      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.60      2/47.28      0/46.48      0/43.80     |0/43.63      0/45.35      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    2/41 (5%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.434N     P=0.255      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.396N     P=0.250      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.399N     P=0.245      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.394N     P=0.257      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.255      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.262N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 21      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      2/43.80     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.6%        |                                                    | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    2/33 (6%)   |                                                    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033 *    (e)          (e)          P=0.208     |                                                    | 
|POLY 3             |     P=0.043 *    (e)          (e)          P=0.233     |                                                    | 
|POLY 1.5           |     P=0.044 *    (e)          (e)          P=0.235     |                                                    | 
|POLY 6             |     P=0.042 *    (e)          (e)          P=0.230     |                                                    | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.208     |                                                    | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |                                                    | 
|ORDER RESTRICTED   |     P=0.028 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    0/50 (0%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |1/43.63      0/45.35      0/42.33      3/43.40      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         0.0%         0.0%         6.9%         | 
|TERMINAL (d)       |                                                        |1/36 (3%)    0/35 (0%)    0/31 (0%)    3/35 (9%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.085      P=0.506N     P=0.530N     P=0.295      | 
|POLY 3             |                                                        |P=0.081      P=0.492N     P=0.506N     P=0.303      | 
|POLY 1.5           |                                                        |P=0.082      P=0.495N     P=0.506N     P=0.302      | 
|POLY 6             |                                                        |P=0.080      P=0.489N     P=0.507N     P=0.305      | 
|LOGISTIC REGRESSION|                                                        |P=0.085      (e)          (e)          P=0.295      | 
|COCH-ARM / FISHERS |                                                        |P=0.086      P=0.500N     P=0.500N     P=0.309      | 
|ORDER RESTRICTED   |                                                        |P=0.037 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 22      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      1/46.48      0/43.80     |2/43.63      1/45.35      1/42.33      1/43.79      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         0.0%        |4.6%         2.2%         2.4%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    1/41 (2%)    0/33 (0%)   |2/36 (6%)    1/35 (3%)    1/31 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |729 (T)      729 (T)      729 (T)      618          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.681      (e)          P=0.515      (e)         |P=0.418N     P=0.510N     P=0.552N     P=0.501N     | 
|POLY 3             |     P=0.677      (e)          P=0.508      (e)         |P=0.416N     P=0.486N     P=0.511N     P=0.499N     | 
|POLY 1.5           |     P=0.684      (e)          P=0.506      (e)         |P=0.416N     P=0.491N     P=0.511N     P=0.501N     | 
|POLY 6             |     P=0.666      (e)          P=0.511      (e)         |P=0.416N     P=0.480N     P=0.512N     P=0.495N     | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.515      (e)         |P=0.415N     P=0.510N     P=0.552N     P=0.501N     | 
|COCH-ARM / FISHERS |     P=0.694      (e)          P=0.500      (e)         |P=0.409N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.389      (e)          (e)          (e)         |P=0.412N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |3/50 (6%)    4/50 (8%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.60      2/47.28      2/46.72      2/43.80     |3/44.05      4/45.56      2/42.58      1/43.40      | 
|POLY-3 PERCENT (g) |     2.2%         4.2%         4.3%         4.6%        |6.8%         8.8%         4.7%         2.3%         | 
|TERMINAL (d)       |     1/38 (3%)    2/41 (5%)    1/41 (2%)    2/33 (6%)   |2/36 (6%)    3/35 (9%)    1/31 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      667          729 (T)     |606          674          662          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.363      P=0.527      P=0.534      P=0.451     |P=0.173N     P=0.502      P=0.540N     P=0.312N     | 
|POLY 3             |     P=0.409      P=0.520      P=0.516      P=0.494     |P=0.170N     P=0.518      P=0.515N     P=0.310N     | 
|POLY 1.5           |     P=0.415      P=0.512      P=0.511      P=0.497     |P=0.169N     P=0.512      P=0.515N     P=0.310N     | 
|POLY 6             |     P=0.399      P=0.530      P=0.522      P=0.489     |P=0.171N     P=0.527      P=0.517N     P=0.310N     | 
|LOGISTIC REGRESSION|     P=0.399      P=0.527      P=0.508      P=0.451     |P=0.167N     P=0.512      P=0.508N     P=0.307N     | 
|COCH-ARM / FISHERS |     P=0.423      P=0.500      P=0.500      P=0.500     |P=0.162N     P=0.500      P=0.500N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.457      (e)          (e)          (e)         |P=0.211N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 23      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/50 (6%)    2/50 (4%)   |5/50 (10%)   5/50 (10%)   3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.60      2/47.28      3/46.72      2/43.80     |5/44.05      5/45.56      3/42.58      2/43.79      | 
|POLY-3 PERCENT (g) |     2.2%         4.2%         6.4%         4.6%        |11.4%        11.0%        7.1%         4.6%         | 
|TERMINAL (d)       |     1/38 (3%)    2/41 (5%)    2/41 (5%)    2/33 (6%)   |4/36 (11%)   4/35 (11%)   2/31 (7%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      667          729 (T)     |606          674          662          618          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.339      P=0.527      P=0.340      P=0.451     |P=0.141N     P=0.626      P=0.420N     P=0.224N     | 
|POLY 3             |     P=0.386      P=0.520      P=0.322      P=0.494     |P=0.134N     P=0.609N     P=0.375N     P=0.218N     | 
|POLY 1.5           |     P=0.394      P=0.512      P=0.316      P=0.497     |P=0.134N     P=0.616N     P=0.374N     P=0.219N     | 
|POLY 6             |     P=0.374      P=0.530      P=0.329      P=0.489     |P=0.134N     P=0.599N     P=0.377N     P=0.215N     | 
|LOGISTIC REGRESSION|     P=0.376      P=0.527      P=0.318      P=0.451     |P=0.134N     P=0.607N     P=0.372N     P=0.218N     | 
|COCH-ARM / FISHERS |     P=0.404      P=0.500      P=0.309      P=0.500     |P=0.128N     P=0.630N     P=0.357N     P=0.218N     | 
|ORDER RESTRICTED   |     P=0.365      (e)          (e)          (e)         |P=0.201N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    1/50 (2%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.86      0/47.28      2/46.48      3/44.39     |0/43.63      1/45.35      4/43.11      2/44.00      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.3%         6.8%        |0.0%         2.2%         9.3%         4.6%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    2/41 (5%)    1/33 (3%)   |0/36 (0%)    1/35 (3%)    1/31 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     661          ---          729 (T)      595         |---          729 (T)      503          535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.083      P=0.477N     P=0.528      P=0.287     |P=0.159      P=0.494      P=0.059      P=0.234      | 
|POLY 3             |     P=0.097      P=0.489N     P=0.512      P=0.301     |P=0.163      P=0.508      P=0.058      P=0.239      | 
|POLY 1.5           |     P=0.099      P=0.493N     P=0.509      P=0.303     |P=0.161      P=0.505      P=0.058      P=0.237      | 
|POLY 6             |     P=0.093      P=0.485N     P=0.516      P=0.298     |P=0.165      P=0.511      P=0.059      P=0.242      | 
|LOGISTIC REGRESSION|     P=0.109      P=0.531N     P=0.506      P=0.309     |P=0.169      P=0.494      P=0.064      P=0.247      | 
|COCH-ARM / FISHERS |     P=0.104      P=0.500N     P=0.500      P=0.309     |P=0.165      P=0.500      P=0.059      P=0.247      | 
|ORDER RESTRICTED   |     P=0.104      (e)          (e)          (e)         |P=0.073      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 24      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    3/50 (6%)   |23/50 (46%)  19/50 (38%)  28/50 (56%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     3/45.53      1/47.28      0/46.48      3/44.19     |23/45.56     19/46.35     28/43.89     27/45.42     | 
|POLY-3 PERCENT (g) |     6.6%         2.1%         0.0%         6.8%        |50.5%        41.0%        63.8%        59.5%        | 
|TERMINAL (d)       |     2/38 (5%)    1/41 (2%)    0/41 (0%)    2/33 (6%)   |19/36 (53%)  16/35 (46%)  23/31 (74%)  22/35 (63%)  | 
|FIRST INCIDENCE    |     301          729 (T)      ---          616         |440          492          503          447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.480      P=0.287N     P=0.114N     P=0.616     |P=0.094      P=0.296N     P=0.073      P=0.250      | 
|POLY 3             |     P=0.514      P=0.292N     P=0.115N     P=0.649     |P=0.089      P=0.238N     P=0.138      P=0.254      | 
|POLY 1.5           |     P=0.519      P=0.298N     P=0.117N     P=0.653     |P=0.093      P=0.249N     P=0.149      P=0.253      | 
|POLY 6             |     P=0.508      P=0.283N     P=0.113N     P=0.644     |P=0.089      P=0.224N     P=0.126      P=0.264      | 
|LOGISTIC REGRESSION|     P=0.555      P=0.406N     P=0.196N     P=0.653N    |P=0.095      P=0.232N     P=0.161      P=0.259      | 
|COCH-ARM / FISHERS |     P=0.526      P=0.309N     P=0.121N     P=0.661N    |P=0.121      P=0.272N     P=0.212      P=0.274      | 
|ORDER RESTRICTED   |     P=0.268      (e)          (e)          (e)         |P=0.089      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |0/43.63      1/45.39      1/42.71      2/44.56      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         2.3%         4.5%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          719          622          447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.154      P=0.505      P=0.495      P=0.247      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.156      P=0.508      P=0.496      P=0.242      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.154      P=0.505      P=0.495      P=0.239      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.159      P=0.512      P=0.496      P=0.246      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.167      P=0.511      P=0.520      P=0.273      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.153      P=0.500      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.122      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 25      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Osteosarcoma or Osteoma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |0/43.63      1/45.39      1/42.71      2/44.56      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         2.3%         4.5%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          719          622          447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.154      P=0.505      P=0.495      P=0.247      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.156      P=0.508      P=0.496      P=0.242      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.154      P=0.505      P=0.495      P=0.239      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.159      P=0.512      P=0.496      P=0.246      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.167      P=0.511      P=0.520      P=0.273      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.153      P=0.500      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.122      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/50 (68%)  38/50 (76%)  37/50 (74%)  34/50 (68%) |38/50 (76%)  27/50 (54%)  33/50 (66%)  31/50 (62%)  | 
|POLY-3 RATE (b)    |     34/48.07     38/47.86     37/48.25     34/46.91    |38/46.54     27/46.09     33/44.32     31/45.66     | 
|POLY-3 PERCENT (g) |     70.7%        79.4%        76.7%        72.5%       |81.6%        58.6%        74.5%        67.9%        | 
|TERMINAL (d)       |     27/38 (71%)  35/41 (85%)  32/41 (78%)  24/33 (73%) |31/36 (86%)  22/35 (63%)  24/31 (77%)  25/35 (71%)  | 
|FIRST INCIDENCE    |     484          604          543          535         |524          673          574          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.243      P=0.472      P=0.541      P=0.314     |P=0.307N     P=0.028N*    P=0.527N     P=0.144N     | 
|POLY 3             |     P=0.528N     P=0.223      P=0.330      P=0.515     |P=0.234N     P=0.010N*    P=0.273N     P=0.090N     | 
|POLY 1.5           |     P=0.499N     P=0.239      P=0.339      P=0.541     |P=0.238N     P=0.011N*    P=0.263N     P=0.094N     | 
|POLY 6             |     P=0.538      P=0.207      P=0.317      P=0.492     |P=0.231N     P=0.009N**   P=0.293N     P=0.085N     | 
|LOGISTIC REGRESSION|     P=0.509N     P=0.343      P=0.382      P=0.569     |P=0.253N     P=0.006N**   P=0.234N     P=0.094N     | 
|COCH-ARM / FISHERS |     P=0.447N     P=0.252      P=0.330      P=0.585N    |P=0.219N     P=0.018N*    P=0.189N     P=0.097N     | 
|ORDER RESTRICTED   |     P=0.419      (e)          (e)          (e)         |P=0.075N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 26      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -      WATER DISINFECTION BYPRODUCTS (SODIUM      
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  22/50 (44%)  30/50 (60%)  27/50 (54%) |33/50 (66%)  38/50 (76%)  41/50 (82%)  41/50 (82%)  | 
|POLY-3 RATE (b)    |     29/49.08     22/49.00     30/50.00     27/47.63    |33/47.24     38/49.43     41/46.20     41/48.78     | 
|POLY-3 PERCENT (g) |     59.1%        44.9%        60.0%        56.7%       |69.9%        76.9%        88.8%        84.1%        | 
|TERMINAL (d)       |     19/38 (50%)  17/41 (42%)  21/41 (51%)  14/33 (42%) |24/36 (67%)  24/35 (69%)  27/31 (87%)  29/35 (83%)  | 
|FIRST INCIDENCE    |     301          431          543          535         |440          461          503          142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.290      P=0.088N     P=0.496N     P=0.526     |P=0.081      P=0.253      P=0.031 *    P=0.097      | 
|POLY 3             |     P=0.435      P=0.113N     P=0.544      P=0.487N    |P=0.041 *    P=0.289      P=0.018 *    P=0.073      | 
|POLY 1.5           |     P=0.451      P=0.114N     P=0.526      P=0.470N    |P=0.040 *    P=0.252      P=0.019 *    P=0.066      | 
|POLY 6             |     P=0.428      P=0.113N     P=0.568      P=0.498N    |P=0.043 *    P=0.334      P=0.018 *    P=0.081      | 
|LOGISTIC REGRESSION|     P=0.525N     P=0.175N     P=0.400      P=0.405N    |P=0.033 *    P=0.197      P=0.028 *    P=0.053      | 
|COCH-ARM / FISHERS |     P=0.500      P=0.115N     P=0.500      P=0.420N    |P=0.043 *    P=0.189      P=0.055      P=0.055      | 
|ORDER RESTRICTED   |     P=0.419      (e)          (e)          (e)         |P=0.025 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  45/50 (90%)  47/50 (94%)  45/50 (90%) |47/50 (94%)  45/50 (90%)  46/50 (92%)  47/50 (94%)  | 
|POLY-3 RATE (b)    |     45/49.62     45/49.46     47/50.00     45/48.32    |47/49.05     45/49.43     46/46.71     47/49.24     | 
|POLY-3 PERCENT (g) |     90.7%        91.0%        94.0%        93.1%       |95.8%        91.0%        98.5%        95.4%        | 
|TERMINAL (d)       |     34/38 (90%)  38/41 (93%)  38/41 (93%)  30/33 (91%) |34/36 (94%)  31/35 (89%)  31/31 (100%) 33/35 (94%)  | 
|FIRST INCIDENCE    |     301          431          543          535         |440          461          503          142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123      P=0.312N     P=0.478N     P=0.252     |P=0.384      P=0.453N     P=0.276      P=0.514      | 
|POLY 3             |     P=0.355      P=0.618      P=0.402      P=0.470     |P=0.439      P=0.288N     P=0.427      P=0.659N     | 
|POLY 1.5           |     P=0.392      P=0.622      P=0.381      P=0.508     |P=0.459      P=0.286N     P=0.512      P=0.642N     | 
|POLY 6             |     P=0.356      P=0.615      P=0.434      P=0.467     |P=0.414      P=0.312N     P=0.315      P=0.684N     | 
|LOGISTIC REGRESSION|     P=0.504      P=0.630N     P=0.332      P=0.618     |P=0.369      P=0.300N     P=0.660      P=0.632      | 
|COCH-ARM / FISHERS |     P=0.533      P=0.630N     P=0.357      P=0.630N    |P=0.482      P=0.357N     P=0.500N     P=0.661N     | 
|ORDER RESTRICTED   |     P=0.465      (e)          (e)          (e)         |P=0.311      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
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