TDMS Study 96010-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) DATE: 03/26/03
EXPERIMENT: 96010 TEST: 04 TIME: 10:45:09
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: 96010A
PATHOLOGIST: HEATH, JAMES E. CAS: 7775-09-9
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1/MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) DATE: 03/26/03
EXPERIMENT: 96010 TEST: 04 TIME: 10:45:09
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: 96010A
PATHOLOGIST: HEATH, JAMES E. CAS: 7775-09-9
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 301 484 561 561 562 603 623 625 638 661 |
| 663 699 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 431 574 577 604 668 698 713 721 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 543 558 562 570 607 667 668 672 673 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2000MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 288 465 535 570 595 605 616 618 640 640 |
| 652 657 664 694 711 719 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 100.0 100.0 98.0 98.0 96.0 96.0 88.0 78.0 76.0 |
| | |
| | |
|500 MG/L | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 92.0 92.0 82.0 |
| | |
| | |
|1000MG/L | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 92.0 90.0 82.0 |
| | |
| | |
|2000MG/L | 100.0 100.0 100.0 98.0 98.0 96.0 94.0 88.0 74.0 66.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 500 MG/L 1000MG/L 2000MG/L |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.0% 82.0% 82.0% 66.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.192 P=0.538N P=0.577N P=0.423 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 581.8 634.2 613.3 611.2 |
|NATURAL DEATHS (C) | (30.6) (32.4) (18.8) (25.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 693.7 711.9 708.2 688.9 |
|(STANDARD ERROR) | (11.4) ( 7.6) ( 7.1) (11.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 1 TERMINAL 36 |
| |
| UNCENSORED DEATHS |
| 440 524 576 588 591 591 597 606 630 639 |
| 660 674 710 |
| CENSORED DEATHS |
| 271 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 500 MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 461 492 513 552 561 568 673 674 682 706 |
| 713 714 717 719 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1000MG/L |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 34 486 503 503 542 574 602 618 618 622 |
| 661 662 683 711 712 719 720 723 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 2000MG/L |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 142 447 455 475 535 540 597 618 646 667 |
| 681 685 685 688 705 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 100.0 100.0 100.0 100.0 98.0 95.9 85.7 77.6 73.5 |
| | |
| | |
|500 MG/L | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 88.0 88.0 70.0 |
| | |
| | |
|1000MG/L | 98.0 98.0 98.0 98.0 98.0 98.0 89.8 85.7 75.5 63.3 |
| | |
| | |
|2000MG/L | 100.0 98.0 98.0 98.0 98.0 92.0 88.0 86.0 82.0 70.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 500 MG/L 1000MG/L 2000MG/L |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 73.5% 70.0% 63.3% 70.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.728 P=0.937 P=0.426 P=0.871 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 602.0 631.5 594.1 571.1 |
|NATURAL DEATHS (C) | (18.9) (24.6) (37.9) (38.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 686.8 699.7 679.4 681.6 |
|(STANDARD ERROR) | (12.6) ( 9.6) (16.6) (15.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
500 MG/L = 2
1000MG/L = 3
2000MG/L = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 41 2 3
|
| 41 2 4 1 3 3 2
| 4 1 4 3122
95 +
| 4 332 2
P | 3 4 2 2
E |
R 90 + 1 4 1 2 2
C |
E | 141 2 2
N | 411 22
T 85 +
| 41 1 33 22
S | 1 1 3 2 2
U |
R 80 + 4 4
V |
I | 1 1
V | 4 4 1 1
A 75 +
L | 4 4
| 4 4
|
70 + 44
|
|
| 4 4
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.
WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
500 MG/L = 2
1000MG/L = 3
2000MG/L = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 4 1 2
|
| 3 4 14 2 32 1
| 4 4 323 2 1 1
95 +
| 4 4 2 2 11
| 4 4 2 2
| 3 3 1 1
P 90 + 43 22
E |
R | 4 2 11 2
C | 11 3
E 85 +
N | 1 41 4 22
T | 4 4 2 2
| 1 1
S 80 + 3 1 14 4 22
U |
R | 1 1
V | 22
I 75 + 3 13 1
V | 34 1 1
A | 4 4 22
L |
70 + 4332 2
|
|
|
65 + 33
| 3 3
|
|
60 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.
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