TDMS Study 96010-04 Pathology Tables
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
FINAL#1/MICE
Facility: Southern Research Institute
Chemical CAS #: 7775-09-9
Lock Date: 10/16/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 10 10 12 7
Moribund Sacrifice 3 5 6 8
Accidently Killed 1
Survivors
Terminal Sacrifice 36 34 31 35
Moribund Sacrifice 1
Other 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (49) (48) (49)
Hemorrhage 1 [3.0]
Intestine Large, Cecum (44) (47) (47) (47)
Edema 4 [2.0] 6 [2.0] 6 [2.2] 6 [1.8]
Hemorrhage 1 [4.0]
Inflammation, Chronic 1 [3.0]
Ulcer 1 [3.0]
Intestine Small, Duodenum (46) (47) (47) (50)
Ulcer 1 [4.0] 1 [2.0]
Epithelium, Hyperplasia 2 [2.5]
Intestine Small, Ileum (42) (45) (46) (47)
Inflammation, Chronic 1 [2.0] 1 [3.0]
Epithelium, Hyperplasia 1 [2.0] 1 [2.0]
Liver (49) (50) (49) (50)
Angiectasis 2 [2.0] 2 [3.5] 1 [3.0]
Basophilic Focus 5 4 1
Clear Cell Focus 3 1
Eosinophilic Focus 9 9 13 7
Hematopoietic Cell Proliferation 7 [2.1] 4 [2.5] 3 [2.7] 8 [2.3]
Hemorrhage 1 [2.0]
Hepatodiaphragmatic Nodule 1
Hyperplasia, Lymphoid 4 [2.0] 7 [2.1] 3 [2.0] 5 [2.0]
Infarct 1 [3.0]
Infiltration Cellular, Mixed Cell 7 [1.9] 7 [1.6] 8 [1.9] 7 [2.1]
Mixed Cell Focus 7 2 3 3
Necrosis, Focal 5 [1.8] 1 [1.0] 4 [2.0] 1 [3.0]
Tension Lipidosis 2 3 1
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Necrosis 2 [2.5] 2 [3.5] 2 [2.5] 2 [3.0]
Hepatocyte, Karyomegaly 3 [2.3]
Hepatocyte, Vacuolization Cytoplasmic 4 [3.3] 3 [3.3] 6 [3.0] 4 [3.5]
Kupffer Cell, Hyperplasia 1 [3.0] 1 [2.0] 2 [3.0]
Kupffer Cell, Pigmentation 3 [2.0] 4 [2.3] 4 [1.8] 7 [2.3]
Mesentery (30) (32) (27) (24)
Angiectasis 1 [3.0] 1 [3.0]
Hemorrhage 1 [4.0]
Inflammation, Chronic 1 [3.0]
Fat, Necrosis 21 [3.0] 24 [3.1] 20 [3.6] 16 [3.3]
Pancreas (46) (47) (49) (48)
Atrophy 2 [2.5] 1 [4.0] 1 [1.0]
Cyst 1 [3.0] 1 [3.0]
Acinus, Hyperplasia, Focal 1 [2.0]
Salivary Glands (48) (47) (49) (50)
Hyperplasia, Lymphoid 16 [2.3] 21 [2.2] 15 [2.4] 18 [2.3]
Stomach, Forestomach (49) (50) (50) (49)
Diverticulum 2 1 1 2
Edema 3 [2.7]
Erosion 1 [2.0] 2 [2.5] 2 [1.5]
Hyperplasia 1 [1.0]
Inflammation, Chronic Active 2 [1.5] 2 [2.0]
Ulcer 2 [2.5] 3 [2.3] 3 [2.3]
Epithelium, Hyperplasia 3 [2.3] 4 [2.0] 9 [2.4] 6 [2.2]
Stomach, Glandular (49) (48) (50) (49)
Erosion 1 [3.0] 2 [2.5]
Ulcer 1 [3.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (3) (1)
Aorta, Mineralization 1 [4.0]
Heart (49) (50) (49) (50)
Cardiomyopathy 1 [2.0] 1 [2.0] 1 [2.0]
Mineralization 1 [2.0] 1 [2.0] 2 [3.5]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (49) (49) (50)
Accessory Adrenal Cortical Nodule 4 [3.0] 2 [3.0] 7 [3.0] 7 [3.0]
Hyperplasia, Focal 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Capsule, Hyperplasia 1 [2.0] 2 [2.0]
Zona Reticularis, Vacuolization Cytoplasmic 1 [3.0] 1 [3.0]
Adrenal Medulla (50) (49) (49) (50)
Hyperplasia 2 [1.0] 2 [1.5] 1 [1.0]
Islets, Pancreatic (46) (47) (49) (49)
Hyperplasia 9 [1.7] 6 [2.0] 4 [2.3] 3 [2.0]
Parathyroid Gland (45) (47) (48) (47)
Cyst 1 [2.0] 1 [3.0] 2 [2.5] 2 [3.0]
Pituitary Gland (46) (45) (48) (50)
Pars Distalis, Angiectasis 1 [1.0] 2 [2.5] 2 [1.5]
Pars Distalis, Cyst 1 [3.0]
Pars Distalis, Hyperplasia, Focal 3 [1.7] 3 [2.3] 3 [2.7] 1 [3.0]
Thyroid Gland (48) (50) (49) (50)
Degeneration, Cystic 25 [2.3] 28 [2.1] 34 [2.5] 32 [2.3]
Follicle, Cyst 1 1 1
Follicular Cell, Cyst 2
Follicular Cell, Hypertrophy 3 [1.3] 2 [2.0] 5 [1.0] 14 [1.4]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (47) (47) (49)
Inflammation, Chronic 2 [2.0] 4 [2.3]
Ovary (45) (45) (47) (50)
Angiectasis 3 [3.0] 2 [3.0] 4 [2.5] 3 [2.7]
Cyst 9 14 14 13
Cyst, Hemorrhagic 1
Hemorrhage 1 [2.0]
Thrombosis 3 1 1
Bilateral, Cyst 1
Follicle, Hemorrhage 1 [2.0] 4 [3.0] 4 [2.3] 9 [2.2]
Granulosa Cell, Hyperplasia 3 [2.7] 7 [2.6]
Uterus (50) (50) (50) (50)
Angiectasis 1 [2.0] 2 [3.5] 1 [4.0]
Hyperplasia, Atypical 1 [3.0]
Hyperplasia, Cystic 45 [3.1] 45 [3.2] 40 [3.1] 41 [3.1]
Inflammation, Chronic 2 [2.5]
Inflammation, Suppurative 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Metaplasia, Squamous 2 [2.5] 1 [2.0]
Endometrium, Hyperplasia, Atypical 1 [2.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 14 [2.4] 28 [2.6] 29 [2.9] 31 [2.7]
Myelofibrosis 1 [3.0] 2 [3.5] 1 [4.0] 2 [2.0]
Lymph Node (7) (5) (11) (9)
Iliac, Hemorrhage 1 [3.0]
Iliac, Hyperplasia, Lymphoid 1 [3.0] 1 [3.0]
Mediastinal, Hyperplasia, Lymphoid 1 [3.0] 1 [3.0] 2 [3.5]
Mediastinal, Pigmentation 1 [2.0]
Pancreatic, Hemorrhage 1 [4.0]
Renal, Hemorrhage 1 [4.0] 1 [3.0]
Lymph Node, Mandibular (46) (46) (49) (49)
Atrophy 1 [3.0] 1 [3.0]
Hematopoietic Cell Proliferation 1 [2.0] 1 [2.0] 1 [2.0]
Hyperplasia, Lymphoid 12 [2.7] 7 [2.4] 7 [2.3] 10 [2.8]
Pigmentation 18 [2.4] 16 [2.6] 18 [2.2] 15 [2.3]
Lymph Node, Mesenteric (47) (49) (49) (49)
Atrophy 1 [3.0] 1 [3.0] 2 [2.5]
Ectasia 2 [3.0] 1 [3.0]
Hematopoietic Cell Proliferation 2 [2.0] 2 [2.5] 1 [2.0] 2 [2.0]
Hemorrhage 4 [3.3] 2 [4.0] 1 [2.0]
Hyperplasia, Lymphoid 10 [2.6] 8 [2.1] 11 [2.8] 6 [2.5]
Pigmentation 1 [2.0] 2 [2.5]
Spleen (49) (48) (49) (50)
Accessory Spleen 1
Hematopoietic Cell Proliferation 39 [2.5] 39 [2.8] 35 [2.8] 39 [2.8]
Hyperplasia, Lymphoid 11 [2.6] 10 [2.3] 5 [3.0] 9 [2.4]
Pigmentation 28 [2.4] 30 [2.6] 28 [2.6] 27 [2.6]
Lymphoid Follicle, Atrophy 1 [3.0] 2 [2.5] 1 [3.0] 2 [3.0]
Thymus (48) (44) (48) (48)
Atrophy 5 [3.0] 7 [2.9] 5 [3.0] 9 [2.9]
Cyst 3 [3.0] 1 [3.0] 1 [3.0]
Hyperplasia, Lymphoid 5 [2.8] 3 [2.7] 4 [3.0] 2 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Hyperplasia 5 [1.4] 11 [1.5] 8 [1.9] 10 [1.4]
Skin (48) (50) (50) (50)
Edema 1 [3.0] 1 [3.0]
Epidermis, Hyperplasia 1 [2.0] 1 [4.0]
Subcutaneous Tissue, Edema 1 [4.0] 2 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Callus 1 [4.0]
Fracture 1 1
Hyperostosis 1 [3.0] 1 [2.0] 4 [2.0] 3 [2.0]
Cranium, Osteopetrosis 1 [3.0]
Femur, Osteopetrosis 1 [2.0] 1 [3.0]
Skeletal Muscle (2) (4) (6)
Angiectasis 1 [3.0]
Atrophy 1 [1.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 1 [4.0] 1 [3.0] 1 [4.0]
Inflammation, Chronic 1 [2.0]
Necrosis 1 [2.0] 1 [3.0]
Peripheral Nerve (2) (2)
Atrophy 1 [2.0] 2 [1.5]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50)
Edema 5 [2.0] 8 [2.1] 3 [2.0] 5 [2.0]
Foreign Body 2
Hemorrhage 5 [1.4] 8 [1.8] 6 [2.0] 4 [2.3]
Hyperplasia, Lymphoid 10 [2.0] 8 [2.1] 3 [2.3] 9 [2.1]
Infiltration Cellular, Polymorphonuclear 1 [3.0]
Infiltration Cellular, Histiocyte 1 [2.0] 1 [4.0] 3 [2.3] 5 [2.0]
Metaplasia, Osseous 1 [1.0] 2 [1.0]
Thrombosis 1 [2.0] 4 [2.3] 1 [3.0]
Alveolar Epithelium, Hyperplasia 2 [2.0] 2 [1.5] 1 [1.0] 2 [1.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (48) (50) (50)
Inflammation, Chronic 3 [2.3] 3 [2.3]
Cornea, Hyperplasia 2 [3.0] 1 [2.0]
Harderian Gland (50) (50) (50) (49)
Cyst 1 [3.0]
Hyperplasia, Focal 1 [2.0] 1 [1.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (49) (50)
Hydronephrosis 1 [3.0] 1 [3.0]
Hyperplasia, Lymphoid 8 [2.1] 9 [2.1] 6 [2.2] 8 [2.1]
Infarct 3 [2.0] 2 [2.5] 4 [1.8] 5 [1.8]
Metaplasia, Osseous 1 [1.0] 3 [1.3] 2 [1.5]
Nephropathy 14 [1.3] 11 [1.4] 14 [1.6] 12 [1.4]
Renal Tubule, Accumulation, Hyaline Droplet 2 [2.5] 1 [2.0] 2 [2.5] 1 [3.0]
Renal Tubule, Dilatation 1 [3.0] 1 [3.0]
Renal Tubule, Necrosis 1 [3.0] 1 [3.0]
Renal Tubule, Pigmentation 3 [2.3] 1 [2.0] 1 [2.0]
Transitional Epithelium, Hyperplasia 1 [1.0]
Urinary Bladder (49) (50) (50) (50)
Hyperplasia, Lymphoid 4 [2.0] 12 [2.4] 4 [2.0] 5 [2.0]
Transitional Epithelium, Hyperplasia 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 7 4 5 7
Moribund Sacrifice 5 5 4 10
Survivors
Terminal Sacrifice 38 41 41 33
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (47) (49) (49) (48)
Edema 1 [2.0] 3 [2.0] 4 [2.0] 2 [2.0]
Inflammation, Chronic 1 [3.0] 1 [2.0]
Intestine Small, Duodenum (48) (50) (49) (49)
Ulcer 1 [2.0] 1 [4.0]
Epithelium, Hyperplasia 1 [2.0] 1 [3.0]
Intestine Small, Jejunum (47) (49) (50) (50)
Epithelium, Hyperplasia 2 [2.5]
Intestine Small, Ileum (47) (49) (49) (49)
Cyst 1 [3.0]
Liver (48) (50) (50) (50)
Angiectasis 2 [2.5] 2 [1.5]
Basophilic Focus 2 3 4
Clear Cell Focus 12 19 19 13
Cyst 1 [2.5] 1 [3.0]
Eosinophilic Focus 11 10 5 11
Hematopoietic Cell Proliferation 1 [3.0] 4 [2.0]
Hemorrhage 1 [3.0] 1 [2.0]
Hyperplasia, Lymphoid 1 [2.0] 1 [2.0]
Infarct 1 [2.0]
Infiltration Cellular, Mixed Cell 2 [1.5] 1 [2.0] 1 [1.0]
Mixed Cell Focus 2 9 8 7
Necrosis, Focal 4 [2.3] 6 [2.8] 7 [2.3] 6 [3.2]
Regeneration, Focal 1 [2.0]
Tension Lipidosis 1 1
Bile Duct, Hyperplasia 2 [2.0]
Centrilobular, Necrosis 1 [3.0] 2 [3.0]
Hepatocyte, Karyomegaly 1 [2.0] 1 [2.0]
Hepatocyte, Vacuolization Cytoplasmic 2 [3.0] 3 [2.7]
Kupffer Cell, Pigmentation 2 [4.0] 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (9) (10) (10) (8)
Infarct 1
Inflammation, Chronic 1 [3.0] 2 [4.0]
Fat, Necrosis 3 [3.7] 8 [3.1] 6 [3.2] 5 [3.2]
Pancreas (48) (50) (50) (50)
Cyst 2 [3.0]
Acinus, Cytoplasmic Alteration 1 [3.0] 1 [3.0]
Salivary Glands (50) (50) (50) (50)
Atrophy 1 [2.0] 2 [2.0]
Hyperplasia, Lymphoid 7 [2.3] 3 [2.0] 6 [2.0] 4 [2.0]
Stomach, Forestomach (49) (50) (50) (50)
Cyst 2
Diverticulum 1 1 2
Erosion 1 [2.0]
Inflammation, Chronic Active 2 [3.0] 2 [2.5] 4 [1.8] 2 [2.0]
Ulcer 1 [3.0] 1 [2.0] 2 [2.0] 1 [2.0]
Epithelium, Hyperplasia 3 [3.0] 7 [2.3] 2 [2.5] 4 [2.0]
Stomach, Glandular (48) (50) (50) (50)
Cyst 1 [3.0] 2 [3.0] 1 [3.0]
Ulcer 1 [3.0]
Tooth (2) (4) (1) (3)
Malformation 2 4 2
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 2 [2.5]
Inflammation, Chronic 2 [2.0] 1 [3.0] 1 [1.0] 1 [3.0]
Mineralization 1 [3.0] 2 [2.0]
Thrombosis 1 [4.0] 1 [4.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 6 [3.0] 5 [3.0] 3 [3.0] 5 [3.0]
Degeneration, Fatty 1 [1.0] 1 [2.0] 2 [1.0]
Hyperplasia, Focal 4 [1.5] 6 [1.7] 7 [1.7] 9 [1.4]
Hypertrophy 1 [2.0]
Hypertrophy, Focal 9 [1.7] 16 [1.8] 11 [1.7] 11 [1.9]
Capsule, Hyperplasia 5 [2.0] 3 [2.0] 1 [3.0] 8 [2.4]
Adrenal Medulla (49) (48) (49) (49)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 [1.0] 1 [2.0] 1 [2.0]
Islets, Pancreatic (48) (50) (50) (50)
Hyperplasia 31 [2.4] 25 [2.3] 28 [2.5] 23 [2.3]
Parathyroid Gland (46) (48) (47) (49)
Cyst 1 [3.0] 2 [3.0] 1 [3.0]
Pituitary Gland (47) (47) (45) (49)
Pars Distalis, Cyst 1 [3.0] 1 [3.0] 2 [3.0] 5 [3.0]
Pars Intermedia, Cyst 1 [3.0]
Thyroid Gland (48) (50) (48) (50)
Degeneration, Cystic 13 [1.8] 17 [2.0] 14 [1.9] 15 [1.7]
Follicular Cell, Hypertrophy 2 [1.0] 1 [1.0] 2 [1.5]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Atypia Cellular 1 [2.0] 6 [2.2] 4 [2.3] 3 [2.3]
Granuloma Sperm 1 [4.0] 1 [4.0]
Inflammation, Chronic 1 [3.0] 1 [2.0] 1 [3.0]
Preputial Gland (50) (50) (50) (50)
Cyst 22 [3.0] 26 [3.0] 15 [3.0] 29 [3.0]
Inflammation, Chronic 28 [2.4] 27 [2.4] 18 [2.2] 21 [2.2]
Prostate (50) (50) (50) (50)
Inflammation, Chronic 1 [2.0] 4 [2.0] 3 [2.7] 5 [2.4]
Seminal Vesicle (50) (50) (50) (50)
Degeneration 1 [3.0] 2 [3.0]
Dilatation 1 [3.0]
Inflammation, Chronic 3 [2.3] 1 [4.0]
Testes (50) (50) (50) (50)
Angiectasis 1 [3.0] 1 [4.0]
Atrophy 1 [2.0] 1 [3.0] 1 [3.0]
Necrosis 1 [3.0]
Germinal Epithelium, Atrophy 1 [1.0] 5 [2.0] 3 [1.7] 4 [1.8]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia 21 [2.2] 12 [2.6] 13 [2.2] 15 [2.6]
Lymph Node (3) (1) (3)
Mediastinal, Hemorrhage 1 [3.0]
Lymph Node, Mandibular (49) (48) (45) (49)
Atrophy 1 [3.0] 1 [2.0]
Hyperplasia, Lymphoid 14 [2.4] 14 [2.3] 16 [2.2] 16 [2.3]
Pigmentation 7 [2.0] 10 [2.2] 9 [2.1] 9 [2.1]
Lymph Node, Mesenteric (47) (50) (50) (50)
Atrophy 2 [2.5] 1 [2.0] 1 [3.0]
Hematopoietic Cell Proliferation 2 [2.5] 4 [2.5] 1 [2.0]
Hemorrhage 4 [1.8] 6 [2.3] 2 [2.0] 4 [2.5]
Hyperplasia, Lymphoid 11 [2.7] 6 [2.8] 6 [2.8] 9 [2.6]
Spleen (48) (50) (50) (50)
Depletion Lymphoid 1 [3.0]
Hematopoietic Cell Proliferation 21 [2.8] 17 [2.6] 18 [2.8] 21 [3.3]
Hyperplasia, Lymphoid 8 [2.3] 9 [2.0] 10 [2.2] 8 [2.1]
Pigmentation 3 [2.0] 1 [2.0] 1 [3.0]
Lymphoid Follicle, Atrophy 1 [3.0] 1 [2.0] 3 [3.0]
Thymus (43) (43) (40) (44)
Atrophy 11 [2.6] 13 [2.6] 4 [2.5] 13 [2.5]
Cyst 1 [3.0] 3 [3.0] 4 [3.0] 4 [3.0]
Hyperplasia, Lymphoid 2 [3.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1
Edema 3 [3.0]
Inflammation, Chronic 1 [3.0] 1 [3.0]
Ulcer 2 [3.5]
Epidermis, Hyperplasia 1 [3.0] 1 [3.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fracture 1 1 2
Hyperostosis 1 [3.0] 1 [3.0]
Skeletal Muscle (3) (1) (3) (2)
Atrophy 1 [2.0]
Infiltration Cellular, Lipocyte 1 [3.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Peripheral Nerve (1) (2) (1)
Atrophy 1 [3.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Edema 6 [2.2] 11 [2.1] 7 [2.0] 8 [2.0]
Foreign Body 1 1
Hemorrhage 5 [1.6] 3 [2.0] 4 [1.3] 5 [2.0]
Hyperplasia, Lymphoid 4 [2.0] 5 [2.0] 7 [2.0] 6 [2.0]
Infiltration Cellular, Histiocyte 8 [2.6] 5 [3.0] 9 [3.1] 10 [2.5]
Metaplasia, Osseous 2 [1.0]
Alveolar Epithelium, Hyperplasia 2 [1.0] 3 [1.7] 1 [1.0] 5 [1.6]
Nose (50) (50) (50) (50)
Foreign Body 1 1 2
Inflammation, Chronic 1 [1.0] 2 [2.5] 1 [1.0] 5 [2.8]
Respiratory Epithelium, Hyperplasia 1 [1.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (50) (50) (50)
Cataract 1 [2.0]
Inflammation, Chronic 3 [2.0]
Harderian Gland (50) (50) (50) (49)
Hyperplasia, Focal 1 [2.0] 1 [2.0]
Inflammation, Chronic 1 [2.0] 3 [2.3] 3 [2.0] 2 [3.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Cyst 14 [3.0] 10 [3.0] 9 [3.0] 10 [2.9]
Hydronephrosis 1 [2.0] 2 [2.0] 2 [2.0] 1 [3.0]
Hyperplasia, Lymphoid 8 [2.3] 6 [2.5] 4 [2.3] 11 [2.3]
Infarct 5 [1.8] 1 [1.0] 4 [1.3] 5 [2.2]
Inflammation, Chronic 1 [3.0] 1 [2.0]
Metaplasia, Osseous 7 [1.4] 5 [2.0] 3 [2.7] 4 [2.5]
Nephropathy 37 [1.3] 42 [1.7] 43 [1.5] 36 [1.6]
Renal Tubule, Accumulation, Hyaline Droplet 1 [3.0] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 12
NTP Experiment-Test: 96010-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 03/26/03
Route: DOSED WATER WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Time: 10:48:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Dilatation 1 [2.0] 2 [2.5] 3 [2.3]
Renal Tubule, Hyperplasia 1 [1.0] 1 [1.0] 1 [1.0]
Renal Tubule, Necrosis 1 [2.0] 2 [3.5]
Renal Tubule, Pigmentation 2 [4.0] 1 [2.0] 1 [2.0]
Urethra (1)
Angiectasis 1 [4.0]
Urinary Bladder (49) (50) (50) (50)
Edema 1 [3.0] 1 [4.0]
Hyperplasia, Lymphoid 1 [2.0] 1 [2.0]
Inflammation, Chronic 1 [3.0]
Transitional Epithelium, Hyperplasia 2 [2.0] 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 13
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