TDMS Study 97006-01 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Battelle Northwest METHYL ISOBUTYL KETONE DATE: 05/11/04
EXPERIMENT: 97006 TEST: 01 TIME: 08:41:16
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP: C97006
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BATTELLE TOXICOLOGY NORTHWEST METHYL ISOBUTYL KETONE DATE: 05/11/04
EXPERIMENT: 97006 TEST: 01 TIME: 8:54:00
SPECIES: RATS, FISCHER 344
TEST TYPE: TWO YEAR ROUTE: RESPIRATORY EX NTP: C97006
CONT: N01-ES-05452 CAS: 108-10-1
MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
TWO YEAR RESPIRATORY EX STUDY OF METHYL ISOBUTYL KETONE
==========================================================================================================
WEEK CONTROL 450 PPM 900 PPM 1800 PPM
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 104.1 50 103.5 99.4 50 102.9 98.8 50 102.0 98.0 50
1 116.5 50 115.4 99.1 50 114.8 98.5 50 113.4 97.3 50
2 158.6 50 157.4 99.2 50 158.3 99.8 50 157.2 99.1 50
3 186.7 50 187.1 100.2 50 189.7 101.6 50 190.9 102.2 50
4 209.4 50 210.4 100.5 50 213.8 102.1 50 217.4 103.8 50
5 231.5 50 233.6 100.9 50 237.7 102.7 50 240.8 104.0 50
6 248.1 50 249.5 100.6 50 254.0 102.4 50 257.1 103.6 50
7 262.8 50 265.5 101.0 50 269.1 102.4 50 273.4 104.0 50
8 277.2 50 281.0 101.4 50 282.1 101.8 50 287.4 103.7 50
9 290.2 50 292.4 100.8 50 296.5 102.2 49 300.3 103.5 50
10 300.8 50 303.7 101.0 50 307.0 102.1 49 311.9 103.7 50
11 310.5 50 312.2 100.5 50 316.3 101.9 49 320.7 103.3 50
12 320.2 50 322.6 100.7 50 326.8 102.1 49 333.1 104.0 50
13 331.3 50 332.6 100.4 50 335.6 101.3 49 342.9 103.5 50
17 365.3 50 365.3 100.0 50 367.0 100.5 49 374.0 102.4 50
21 387.3 50 387.6 100.1 50 388.5 100.3 49 396.0 102.2 50
25 408.7 50 408.2 99.9 50 407.2 99.6 49 416.2 101.8 50
29 427.1 50 426.6 99.9 50 426.8 99.9 49 432.9 101.4 50
33 438.1 50 440.8 100.6 50 439.7 100.4 48 445.9 101.8 50
37 450.1 50 451.2 100.2 50 448.9 99.7 48 453.6 100.8 50
42 459.5 50 461.4 100.4 50 454.4 98.9 48 465.1 101.2 50
45 472.1 50 472.0 100.0 50 467.9 99.1 48 475.1 100.6 50
49 478.6 50 481.9 100.7 49 475.0 99.2 48 481.0 100.5 50
53 487.8 50 490.3 100.5 49 481.2 98.6 48 487.8 100.0 50
57 492.8 50 495.7 100.6 49 485.6 98.5 48 492.2 99.9 50
61 497.5 50 501.5 100.8 47 490.2 98.5 48 495.8 99.7 50
65 503.7 50 504.4 100.1 47 491.9 97.7 48 499.3 99.1 50
69 506.5 49 508.3 100.4 46 495.4 97.8 48 501.9 99.1 50
73 506.9 47 511.6 100.9 46 499.6 98.6 48 503.2 99.3 49
77 514.7 47 517.5 100.5 46 498.3 96.8 48 502.8 97.7 49
81 521.7 46 524.8 100.6 45 504.9 96.8 45 504.5 96.7 48
85 526.0 44 522.5 99.3 45 503.3 95.7 43 506.0 96.2 47
89 525.1 44 525.7 100.1 39 505.0 96.2 42 505.0 96.2 42
91 527.2 42 523.6 99.3 39 502.8 95.4 41 496.9 94.3 40
93 527.3 42 523.9 99.4 38 508.9 96.5 39 502.8 95.4 34
95 523.4 42 528.5 101.0 34 500.7 95.7 38 496.8 94.9 31
97 521.4 41 532.3 102.1 32 499.7 95.8 35 494.8 94.9 28
99 528.6 37 524.8 99.3 31 489.5 92.6 34 484.6 91.7 27
101 529.3 34 521.2 98.5 30 486.5 91.9 29 487.6 92.1 21
103 521.4 33 507.6 97.4 29 489.4 93.9 26 489.9 94.0 19
TERM. SAC. 32 28 25 19
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
TWO YEAR RESPIRATORY EX STUDY OF METHYL ISOBUTYL KETONE
==========================================================================================================
WEEK CONTROL 450 PPM 900 PPM 1800 PPM
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 93.5 50 92.2 98.6 50 92.1 98.5 50 93.3 99.8 50
1 100.3 50 98.8 98.5 50 98.5 98.2 50 100.2 99.9 50
2 121.6 50 120.6 99.2 50 120.3 98.9 50 123.2 101.3 50
3 134.0 50 132.9 99.2 50 133.8 99.9 50 136.4 101.8 50
4 142.0 50 144.0 101.4 50 144.7 101.9 50 147.2 103.7 50
5 153.2 50 153.4 100.1 50 155.2 101.3 50 156.9 102.4 50
6 160.0 50 161.7 101.1 50 162.8 101.8 50 164.8 103.0 50
7 165.6 50 167.7 101.3 50 168.9 102.0 50 171.5 103.6 50
8 170.2 50 172.5 101.4 50 173.4 101.9 50 175.3 103.0 50
9 174.5 50 177.0 101.4 50 177.7 101.8 50 180.7 103.6 50
10 180.2 50 182.7 101.4 50 184.1 102.2 50 186.1 103.3 50
11 182.8 50 186.6 102.1 50 188.0 102.8 50 189.8 103.8 50
12 187.2 50 190.1 101.5 50 192.8 103.0 50 194.4 103.8 50
13 190.2 50 193.1 101.5 50 195.7 102.9 50 197.2 103.7 50
17 205.7 50 207.5 100.9 50 209.9 102.0 50 212.0 103.1 50
21 213.2 50 214.4 100.6 50 217.4 102.0 50 217.9 102.2 50
25 225.2 50 225.4 100.1 50 228.4 101.4 50 227.9 101.2 50
29 234.3 50 233.6 99.7 50 236.6 101.0 50 236.2 100.8 50
33 241.2 50 239.4 99.3 50 244.8 101.5 50 241.2 100.0 50
37 249.5 50 248.4 99.6 50 252.8 101.3 50 247.9 99.4 50
42 258.0 50 256.4 99.4 50 258.8 100.3 50 256.3 99.3 50
45 268.1 50 265.4 99.0 50 269.3 100.4 50 265.8 99.1 50
49 278.8 50 277.5 99.5 50 282.3 101.3 50 276.7 99.2 50
53 291.5 49 290.6 99.7 49 295.4 101.3 50 290.0 99.5 49
57 300.2 49 299.2 99.7 49 303.7 101.2 50 296.4 98.7 48
61 310.7 49 308.9 99.4 49 315.6 101.6 50 307.0 98.8 48
65 319.2 48 314.0 98.4 49 322.6 101.1 50 312.0 97.7 47
69 325.5 48 321.7 98.8 48 328.5 100.9 50 316.5 97.2 47
73 335.8 48 330.0 98.3 48 336.9 100.3 48 327.5 97.5 44
77 343.9 47 337.2 98.1 47 345.0 100.3 47 334.7 97.3 44
81 350.0 47 343.0 98.0 45 350.6 100.2 46 339.5 97.0 43
85 354.5 45 345.7 97.5 43 352.6 99.5 43 345.2 97.4 43
89 363.3 43 356.9 98.2 42 357.2 98.3 40 347.7 95.7 43
91 365.2 43 359.4 98.4 42 357.5 97.9 39 350.9 96.1 42
93 365.4 41 360.1 98.5 42 369.8 101.2 35 350.2 95.8 42
95 365.0 41 357.6 98.0 42 368.8 101.0 33 352.7 96.6 41
97 365.6 41 359.8 98.4 41 373.4 102.1 31 354.8 97.0 40
99 362.0 40 354.2 97.8 41 366.2 101.2 30 356.9 98.6 36
101 358.8 39 350.3 97.6 40 370.9 103.4 29 359.9 100.3 34
103 362.9 35 358.4 98.8 36 375.4 103.4 28 358.3 98.7 34
TERM. SAC. 35 34 26 32
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.