TDMS Study 97006-01 Pathology Tables
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:57
FINAL#1/RATS
Facility: Battelle Northwest
Chemical CAS #: 108-10-1
Lock Date: 01/24/03
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 14 14 20 15
Natural Death 1 2 4 3
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 35 33 26 32
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (49) (49) (50)
Foreign Body 1 (2%)
Intestine Small, Duodenum (50) (50) (49) (50)
Foreign Body 1 (2%)
Intestine Small, Jejunum (50) (49) (49) (49)
Necrosis 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 36 (72%) 24 (48%) 26 (52%) 20 (40%)
Clear Cell Focus 11 (22%) 10 (20%) 11 (22%) 7 (14%)
Eosinophilic Focus 3 (6%) 1 (2%) 2 (4%)
Hepatodiaphragmatic Nodule 8 (16%) 12 (24%) 9 (18%) 5 (10%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 1 (2%) 3 (6%)
Necrosis 2 (4%) 3 (6%)
Vacuolization Cytoplasmic 3 (6%) 3 (6%) 5 (10%) 4 (8%)
Hepatocyte, Regeneration 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Serosa, Fibrosis 1 (2%)
Mesentery (18) (17) (15) (15)
Fibrosis 1 (6%)
Hemorrhage 1 (6%)
Inflammation, Granulomatous 1 (7%)
Necrosis 18 (100%) 15 (88%) 15 (100%) 14 (93%)
Pancreas (50) (50) (50) (50)
Cyst 1 (2%)
Acinus, Atrophy 1 (2%) 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Hyperkeratosis 1 (2%)
Hyperplasia, Squamous 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis 1 (2%)
Ulcer 2 (4%) 1 (2%) 1 (2%)
Tongue (1) (1) (3) (2)
Epithelium, Hyperplasia 1 (100%) 1 (100%) 3 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 1 (2%) 1 (2%) 3 (6%) 2 (4%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 9 (18%) 4 (8%) 13 (26%) 9 (18%)
Adrenal Medulla (50) (50) (50) (50)
Atrophy 1 (2%)
Hyperplasia 2 (4%)
Necrosis 1 (2%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (49) (50) (50) (50)
Cyst 3 (6%) 6 (12%) 4 (8%) 3 (6%)
Hemorrhage 2 (4%) 2 (4%) 3 (6%)
Hyperplasia 11 (22%) 11 (22%) 8 (16%) 10 (20%)
Thyroid Gland (50) (50) (50) (50)
Cyst 1 (2%)
C-Cell, Hyperplasia 4 (8%) 2 (4%) 2 (4%) 5 (10%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (50)
Cyst 2 (4%) 3 (6%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hyperplasia 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50)
Cyst 6 (12%) 10 (20%) 7 (14%) 4 (8%)
Cyst, Multiple 1 (2%)
Uterus (50) (50) (50) (50)
Cyst 1 (2%)
Decidual Reaction 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 2 (4%)
Necrosis 2 (4%) 1 (2%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia 1 (2%) 2 (4%) 3 (6%) 3 (6%)
Endometrium, Inflammation, Suppurative 1 (2%)
Myometrium, Hyperplasia 1 (2%)
Vagina (2) (1)
Muscularis, Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Myelofibrosis 1 (2%)
Lymph Node (1) (2) (2) (3)
Pancreatic, Hemorrhage 1 (50%)
Lymph Node, Bronchial (9) (12) (8) (7)
Ectasia 2 (22%)
Hemorrhage 1 (8%)
Hyperplasia, Lymphoid 2 (17%)
Pigmentation 1 (11%) 2 (17%)
Lymph Node, Mediastinal (46) (44) (46) (49)
Angiectasis 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Necrosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Epithelium, Hyperplasia 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%) 1 (2%) 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia, Focal, Squamous 1 (2%)
Inflammation, Acute 2 (4%)
Ulcer 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 8 (16%) 11 (22%) 10 (20%) 7 (14%)
Gliosis 1 (2%)
Hemorrhage 5 (10%) 4 (8%) 10 (20%) 5 (10%)
Necrosis 1 (2%) 2 (4%)
Thrombosis 1 (2%)
Cerebrum, Pigmentation 1 (2%)
Spinal Cord (10) (4) (6) (14)
Cyst Epithelial Inclusion 1 (7%)
Hemorrhage 1 (7%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Foreign Body 1 (2%) 2 (4%) 3 (6%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%)
Epiglottis, Hyperplasia 1 (2%)
Epiglottis, Metaplasia, Squamous 1 (2%) 2 (4%) 2 (4%)
Lung (50) (50) (50) (50)
Foreign Body 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 2 (4%) 10 (20%) 7 (14%) 4 (8%)
Inflammation, Granulomatous 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 5 (10%) 2 (4%) 6 (12%)
Alveolar Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolus, Emphysema 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 13 (26%) 2 (4%) 5 (10%) 11 (22%)
Alveolus, Pigmentation 1 (2%)
Bronchiole, Hyperplasia 1 (2%) 2 (4%) 2 (4%) 3 (6%)
Interstitium, Fibrosis 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Nose (50) (50) (50) (50)
Foreign Body 2 (4%) 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%) 6 (12%)
Goblet Cell, Hyperplasia 2 (4%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 5 (10%) 2 (4%) 2 (4%)
Olfactory Epithelium, Degeneration, Hyaline 1 (2%) 1 (2%) 2 (4%)
Respiratory Epithelium, Degeneration, Hyaline 9 (18%) 3 (6%) 8 (16%) 9 (18%)
Respiratory Epithelium, Hyperplasia 2 (4%) 2 (4%)
Pleura (50) (50) (50) (50)
Fibrosis 12 (24%) 7 (14%) 4 (8%) 5 (10%)
Inflammation, Chronic 7 (14%) 7 (14%) 1 (2%) 1 (2%)
Mesothelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (50) (48) (49)
Inflammation, Suppurative 1 (2%) 2 (4%)
Cornea, Inflammation, Suppurative 1 (2%)
Lens, Cataract 2 (4%) 3 (6%) 4 (8%) 4 (8%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Infarct 1 (2%)
Nephropathy 19 (38%) 35 (70%) 38 (76%) 44 (88%)
Papilla, Mineralization 3 (6%) 5 (10%) 3 (6%) 3 (6%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Pelvis, Transitional Epithelium,
Mineralization 9 (18%) 6 (12%) 7 (14%) 2 (4%)
Renal Tubule, Cyst 1 (2%) 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 14 16 21 29
Natural Death 4 5 4 2
Accidently Killed 1
Survivors
Terminal Sacrifice 32 28 25 19
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (48) (50) (50)
Ulcer 1 (2%) 2 (4%)
Intestine Small, Ileum (48) (47) (48) (49)
Diverticulum 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 11 (22%) 5 (10%) 13 (26%) 4 (8%)
Clear Cell Focus 14 (28%) 13 (26%) 17 (34%) 9 (18%)
Degeneration, Cystic 1 (2%) 1 (2%) 3 (6%)
Eosinophilic Focus 2 (4%) 6 (12%) 10 (20%) 9 (18%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 6 (12%) 7 (14%) 7 (14%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 1 (2%) 2 (4%) 1 (2%)
Necrosis 1 (2%) 6 (12%) 1 (2%)
Vacuolization Cytoplasmic 4 (8%) 2 (4%) 2 (4%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 3 (6%) 4 (8%) 4 (8%)
Bile Duct, Inflammation, Suppurative 1 (2%)
Centrilobular, Necrosis 1 (2%) 1 (2%) 1 (2%) 4 (8%)
Hepatocyte, Regeneration 2 (4%) 1 (2%) 4 (8%)
Periportal, Inflammation, Chronic 1 (2%)
Mesentery (10) (12) (9) (7)
Necrosis 10 (100%) 12 (100%) 9 (100%) 7 (100%)
Oral Mucosa (2)
Pharyngeal, Hyperplasia, Squamous 1 (50%)
Pancreas (50) (48) (50) (50)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Atrophy 4 (8%) 7 (15%) 5 (10%) 2 (4%)
Artery, Thrombosis 1 (2%)
Salivary Glands (50) (48) (50) (50)
Hyperplasia 1 (2%)
Stomach, Forestomach (50) (48) (50) (50)
Hyperplasia, Squamous 1 (2%) 1 (2%)
Ulcer 3 (6%) 1 (2%) 6 (12%) 6 (12%)
Stomach, Glandular (50) (48) (50) (50)
Erosion 1 (2%) 1 (2%) 2 (4%) 3 (6%)
Ulcer 1 (2%)
Serosa, Fibrosis 1 (2%)
Tongue (1) (1)
Epithelium, Hyperplasia 1 (100%) 1 (100%)
Tooth (1)
Peridontal Tissue, Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (50) (50)
Cardiomyopathy 14 (28%) 9 (18%) 12 (24%) 8 (16%)
Atrium, Thrombosis 2 (4%) 4 (8%) 3 (6%) 1 (2%)
Myocardium, Mineralization 1 (2%)
Pericardium, Fibrosis 1 (2%)
Pericardium, Inflammation, Chronic 1 (2%)
Valve, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (48) (50) (50)
Atrophy 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 7 (14%) 3 (6%) 6 (12%) 3 (6%)
Adrenal Medulla (50) (48) (50) (50)
Atrophy 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 13 (26%) 18 (38%) 18 (36%) 24 (48%)
Thrombosis 1 (2%)
Islets, Pancreatic (50) (48) (50) (50)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (49) (48) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (2%)
Pituitary Gland (50) (49) (50) (50)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Cyst 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 4 (8%) 1 (2%) 1 (2%)
Hyperplasia 8 (16%) 8 (16%) 9 (18%) 9 (18%)
Thyroid Gland (50) (48) (50) (50)
C-Cell, Hyperplasia 4 (8%) 3 (6%) 5 (10%) 1 (2%)
Follicle, Cyst 1 (2%) 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (50) (49) (50) (50)
Cyst 1 (2%) 2 (4%)
Hyperplasia 1 (2%) 2 (4%) 3 (6%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Prostate (50) (49) (50) (50)
Inflammation, Suppurative 3 (6%) 1 (2%) 2 (4%)
Seminal Vesicle (50) (49) (50) (50)
Hyperplasia 1 (2%)
Testes (50) (50) (50) (50)
Germinal Epithelium, Atrophy 10 (20%) 8 (16%) 8 (16%) 15 (30%)
Interstitial Cell, Hyperplasia 4 (8%) 3 (6%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (50)
Hyperplasia, Reticulum Cell 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (7) (7) (12) (15)
Infiltration Cellular, Histiocyte 1 (8%)
Deep Cervical, Hemorrhage 1 (14%)
Deep Cervical, Infiltration Cellular,
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Histiocyte 1 (14%)
Deep Cervical, Pigmentation 1 (7%)
Pancreatic, Ectasia 2 (29%)
Pancreatic, Pigmentation 1 (8%)
Renal, Ectasia 1 (8%)
Lymph Node, Bronchial (11) (13) (12) (7)
Angiectasis 1 (9%)
Ectasia 3 (27%) 2 (15%) 1 (8%)
Hemorrhage 1 (8%)
Infiltration Cellular, Histiocyte 1 (9%) 1 (8%)
Pigmentation 1 (9%) 1 (8%)
Lymph Node, Mesenteric (50) (48) (50) (50)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Lymph Node, Mediastinal (41) (44) (46) (44)
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Pigmentation 1 (2%) 1 (2%)
Spleen (50) (50) (50) (50)
Accessory Spleen 2 (4%) 1 (2%) 1 (2%)
Fibrosis 2 (4%) 5 (10%) 3 (6%) 8 (16%)
Hemorrhage 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Necrosis 4 (8%) 4 (8%) 6 (12%) 4 (8%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (49) (50) (50)
Galactocele 5 (10%) 1 (2%) 3 (6%)
Skin (50) (49) (50) (50)
Cyst Epithelial Inclusion 3 (6%) 3 (6%) 4 (8%)
Hyperkeratosis 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Hyperplasia, Focal, Squamous 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Granulomatous 1 (2%) 2 (4%)
Sebaceous Gland, Hyperplasia 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Hyperostosis 1 (2%)
Cranium, Maxilla, Fracture 1 (2%)
Tibia, Fracture 1 (2%)
Skeletal Muscle (3) (3) (4) (6)
Hemorrhage 1 (17%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Compression 8 (16%) 8 (16%) 3 (6%) 6 (12%)
Hemorrhage 5 (10%) 3 (6%) 6 (12%) 4 (8%)
Spinal Cord (2) (3) (5) (5)
Gliosis 1 (20%)
Inflammation 1 (20%)
Neuron, Degeneration 1 (20%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (48) (50) (50)
Foreign Body 2 (4%) 3 (6%) 6 (12%) 4 (8%)
Inflammation, Suppurative 2 (4%) 2 (4%) 2 (4%)
Epiglottis, Hyperplasia 1 (2%)
Epiglottis, Metaplasia, Squamous 1 (2%)
Lung (50) (49) (50) (50)
Hemorrhage 2 (4%) 5 (10%) 5 (10%)
Inflammation, Chronic 4 (8%) 2 (4%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 7 (14%) 4 (8%) 4 (8%)
Alveolar Epithelium, Metaplasia, Squamous 1 (2%)
Alveolus, Emphysema 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 10 (20%) 5 (10%) 6 (12%) 6 (12%)
Alveolus, Pigmentation 1 (2%)
Bronchiole, Hyperplasia 1 (2%)
Bronchiole, Alveolus, Foreign Body 1 (2%)
Interstitium, Fibrosis 2 (4%) 3 (6%) 1 (2%)
Nose (50) (49) (50) (50)
Foreign Body 1 (2%) 3 (6%) 4 (8%) 7 (14%)
Inflammation, Suppurative 4 (8%) 8 (16%) 4 (8%) 10 (20%)
Goblet Cell, Hyperplasia 1 (2%) 1 (2%) 5 (10%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 08:44:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Respiratory Epithelium, Hyperplasia 4 (8%) 1 (2%) 3 (6%) 3 (6%)
Pleura (50) (49) (50) (50)
Fibrosis 3 (6%)
Inflammation, Chronic 6 (12%) 6 (12%) 4 (8%)
Mesothelium, Hyperplasia 1 (2%) 1 (2%)
Trachea (50) (48) (50) (50)
Inflammation, Suppurative 2 (4%)
Epithelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (45) (46) (48)
Anterior Chamber, Hemorrhage 1 (2%)
Anterior Chamber, Inflammation, Suppurative 1 (2%)
Cornea, Hyperplasia 1 (2%)
Lens, Cataract 7 (14%) 6 (13%) 3 (7%) 2 (4%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Infarct 4 (8%) 3 (6%)
Nephropathy 42 (84%) 45 (90%) 47 (94%) 50 (100%)
Papilla, Mineralization 1 (2%) 6 (12%) 22 (44%) 29 (58%)
Pelvis, Dilatation 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%) 5 (10%) 6 (12%) 19 (38%)
Renal Tubule, Accumulation, Hyaline Droplet 2 (4%) 2 (4%)
Renal Tubule, Cyst 1 (2%) 1 (2%) 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 11 (22%) 3 (6%) 18 (36%)
Renal Tubule, Pigmentation 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (50) (48) (50) (50)
Calculus Micro Observation Only 1 (2%) 2 (4%) 2 (4%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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