TDMS Study 97006-01 Pathology Tables
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 09:05:20
FINAL#1/RATS
Facility: Battelle Northwest
Chemical CAS #: 108-10-1
Lock Date: 01/24/03
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 09:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 14 14 20 15
Natural Death 1 2 4 3
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 35 33 26 32
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (49) (49) (50)
Foreign Body 1 [4.0]
Intestine Small, Duodenum (50) (50) (49) (50)
Foreign Body 1
Intestine Small, Jejunum (50) (49) (49) (49)
Necrosis 1 [4.0]
Liver (50) (50) (50) (50)
Angiectasis 1 [3.0]
Basophilic Focus 36 24 26 20
Clear Cell Focus 11 10 11 7
Eosinophilic Focus 3 1 2
Hepatodiaphragmatic Nodule 8 [4.0] 12 [4.0] 9 [4.0] 5 [4.0]
Inflammation, Granulomatous 1 [2.0]
Mixed Cell Focus 1 3
Necrosis 2 [3.0] 3 [2.0]
Vacuolization Cytoplasmic 3 [2.7] 3 [2.3] 5 [2.8] 4 [2.0]
Hepatocyte, Regeneration 1 [4.0] 1 [4.0] 2 [3.0] 2 [4.0]
Serosa, Fibrosis 1 [2.0]
Mesentery (18) (17) (15) (15)
Fibrosis 1 [3.0]
Hemorrhage 1 [3.0]
Inflammation, Granulomatous 1 [2.0]
Necrosis 18 [3.0] 15 [3.0] 15 [3.0] 14 [2.9]
Pancreas (50) (50) (50) (50)
Cyst 1 [3.0]
Acinus, Atrophy 1 [3.0] 1 [2.0] 1 [2.0]
Stomach, Forestomach (50) (50) (50) (50)
Hyperkeratosis 1 [2.0]
Hyperplasia, Squamous 2 [2.0] 2 [2.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 09:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis 1 [3.0]
Ulcer 2 [4.0] 1 [4.0] 1 [4.0]
Tongue (1) (1) (3) (2)
Epithelium, Hyperplasia 1 [4.0] 1 [1.0] 3 [2.0] 2 [2.5]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 1 [2.0] 1 [3.0] 3 [2.0] 2 [2.0]
Atrium, Thrombosis 1 [4.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hyperplasia 1 [2.0] 1 [2.0]
Vacuolization Cytoplasmic 9 [2.3] 4 [2.5] 13 [2.6] 9 [2.0]
Adrenal Medulla (50) (50) (50) (50)
Atrophy 1 [4.0]
Hyperplasia 2 [4.0]
Necrosis 1 [4.0]
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 1 [3.0] 1 [4.0] 1 [4.0]
Pituitary Gland (49) (50) (50) (50)
Cyst 3 [2.7] 6 [3.3] 4 [3.3] 3 [3.0]
Hemorrhage 2 [3.5] 2 [3.5] 3 [3.3]
Hyperplasia 11 [3.2] 11 [3.5] 8 [3.3] 10 [3.2]
Thyroid Gland (50) (50) (50) (50)
Cyst 1 [2.0]
C-Cell, Hyperplasia 4 [2.8] 2 [3.0] 2 [3.0] 5 [2.6]
Follicular Cell, Hyperplasia 1 [3.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (50) (50) (50)
Cyst 2 [2.5] 3 [2.7] 1 [3.0] 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 09:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hyperplasia 1 [3.0] 3 [4.0] 1 [2.0] 1 [4.0]
Inflammation, Chronic 1 [3.0] 1 [3.0]
Ovary (50) (50) (50) (50)
Cyst 6 [3.3] 10 [2.8] 7 [3.4] 4 [3.8]
Cyst, Multiple 1 [3.0]
Uterus (50) (50) (50) (50)
Cyst 1 [4.0]
Decidual Reaction 1 [3.0]
Hemorrhage 1 [4.0] 1 [4.0] 2 [4.0]
Necrosis 2 [4.0] 1 [4.0]
Thrombosis 1 [4.0]
Endometrium, Hyperplasia 1 [1.0] 2 [2.0] 3 [2.7] 3 [2.3]
Endometrium, Inflammation, Suppurative 1 [3.0]
Myometrium, Hyperplasia 1 [3.0]
Vagina (2) (1)
Muscularis, Hyperplasia 1 [4.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Myelofibrosis 1 [3.0]
Lymph Node (1) (2) (2) (3)
Pancreatic, Hemorrhage 1 [3.0]
Lymph Node, Bronchial (9) (12) (8) (7)
Ectasia 2 [2.5]
Hemorrhage 1 [2.0]
Hyperplasia, Lymphoid 2 [3.0]
Pigmentation 1 [3.0] 2 [2.5]
Lymph Node, Mediastinal (46) (44) (46) (49)
Angiectasis 1 [4.0]
Spleen (50) (50) (50) (50)
Accessory Spleen 1 1
Fibrosis 1 [2.0]
Hemorrhage 1 [4.0] 1 [4.0]
Inflammation, Granulomatous 1 [3.0]
Necrosis 1 [4.0] 1 [4.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 1 1 1
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 09:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Epithelium, Hyperplasia 1 [3.0]
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 [4.0] 1 [4.0] 1 [4.0]
Hyperkeratosis 1 [3.0]
Hyperplasia, Focal, Squamous 1 [2.0]
Inflammation, Acute 2 [2.0]
Ulcer 1 [3.0] 1 [4.0] 2 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 8 [3.4] 11 [3.7] 10 [3.9] 7 [3.7]
Gliosis 1 [3.0]
Hemorrhage 5 [3.2] 4 [3.3] 10 [3.3] 5 [2.8]
Necrosis 1 [4.0] 2 [4.0]
Thrombosis 1 [4.0]
Cerebrum, Pigmentation 1 [2.0]
Spinal Cord (10) (4) (6) (14)
Cyst Epithelial Inclusion 1 [3.0]
Hemorrhage 1 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Foreign Body 1 [4.0] 2 [4.0] 3 [4.0] 2 [4.0]
Inflammation, Chronic 1 [1.0] 1 [3.0]
Inflammation, Suppurative 1 [2.0] 2 [2.0]
Epiglottis, Hyperplasia 1 [2.0]
Epiglottis, Metaplasia, Squamous 1 [2.0] 2 [1.5] 2 [1.5]
Lung (50) (50) (50) (50)
Foreign Body 1 [3.0]
Hemorrhage 1 [2.0]
Inflammation, Chronic 2 [1.0] 10 [1.8] 7 [1.9] 4 [1.3]
Inflammation, Granulomatous 1 [3.0]
Alveolar Epithelium, Hyperplasia 3 [1.3] 5 [2.0] 2 [2.0] 6 [1.3]
Alveolar Epithelium, Metaplasia, Squamous 1 [1.0] 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 09:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolus, Emphysema 1 [3.0]
Alveolus, Infiltration Cellular, Histiocyte 13 [1.2] 2 [1.0] 5 [1.4] 11 [1.1]
Alveolus, Pigmentation 1 [2.0]
Bronchiole, Hyperplasia 1 [3.0] 2 [2.0] 2 [2.5] 3 [2.3]
Interstitium, Fibrosis 2 [1.0] 2 [2.0] 2 [2.5] 1 [1.0]
Nose (50) (50) (50) (50)
Foreign Body 2 [3.0] 2 [3.0] 1 [3.0]
Inflammation, Suppurative 1 [2.0] 6 [1.2]
Goblet Cell, Hyperplasia 2 [2.0] 1 [2.0]
Nasolacrimal Duct, Inflammation, Suppurative 5 [1.8] 2 [2.0] 2 [1.0]
Olfactory Epithelium, Degeneration, Hyaline 1 [2.0] 1 [2.0] 2 [1.5]
Respiratory Epithelium, Degeneration, Hyaline 9 [1.4] 3 [1.7] 8 [2.0] 9 [2.1]
Respiratory Epithelium, Hyperplasia 2 [2.0] 2 [2.5]
Pleura (50) (50) (50) (50)
Fibrosis 12 [1.2] 7 [1.7] 4 [1.3] 5 [1.0]
Inflammation, Chronic 7 [1.6] 7 [1.7] 1 [1.0] 1 [1.0]
Mesothelium, Hyperplasia 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (50) (48) (49)
Inflammation, Suppurative 1 [4.0] 2 [2.5]
Cornea, Inflammation, Suppurative 1 [3.0]
Lens, Cataract 2 [3.5] 3 [3.0] 4 [3.0] 4 [3.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Infarct 1
Nephropathy 19 [1.4] 35 [1.5] 38 [1.5] 44 [1.9]
Papilla, Mineralization 3 [1.0] 5 [1.0] 3 [1.0] 3 [1.0]
Pelvis, Transitional Epithelium, Hyperplasia 1 [1.0] 1 [1.0] 1 [1.0]
Pelvis, Transitional Epithelium,
Mineralization 9 [1.1] 6 [1.2] 7 [1.1] 2 [1.0]
Renal Tubule, Cyst 1 1
Renal Tubule, Hyperplasia 1 [2.0] 1 [2.0] 1 [3.0]
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 09:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 14 16 21 29
Natural Death 4 5 4 2
Accidently Killed 1
Survivors
Terminal Sacrifice 32 28 25 19
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (48) (50) (50)
Ulcer 1 [4.0] 2 [4.0]
Intestine Small, Ileum (48) (47) (48) (49)
Diverticulum 1 [4.0]
Liver (50) (50) (50) (50)
Angiectasis 1 [2.0] 1 [3.0]
Basophilic Focus 11 5 13 4
Clear Cell Focus 14 13 17 9
Degeneration, Cystic 1 [2.0] 1 [4.0] 3 [3.0]
Eosinophilic Focus 2 6 10 9
Hemorrhage 1 [4.0]
Hepatodiaphragmatic Nodule 3 [4.0] 6 [4.0] 7 [4.0] 7 [4.0]
Inflammation, Granulomatous 1 [3.0]
Mixed Cell Focus 1 2 1
Necrosis 1 [4.0] 6 [3.3] 1 [3.0]
Vacuolization Cytoplasmic 4 [2.5] 2 [2.5] 2 [3.5]
Bile Duct, Cyst 1 [3.0]
Bile Duct, Hyperplasia 3 [3.0] 4 [3.0] 4 [3.0]
Bile Duct, Inflammation, Suppurative 1 [4.0]
Centrilobular, Necrosis 1 [2.0] 1 [3.0] 1 [2.0] 4 [1.8]
Hepatocyte, Regeneration 2 [4.0] 1 [3.0] 4 [3.8]
Periportal, Inflammation, Chronic 1 [3.0]
Mesentery (10) (12) (9) (7)
Necrosis 10 [2.8] 12 [3.0] 9 [3.0] 7 [3.0]
Oral Mucosa (2)
Pharyngeal, Hyperplasia, Squamous 1 [4.0]
Pancreas (50) (48) (50) (50)
Hemorrhage 1 [4.0]
Necrosis 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 09:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Atrophy 4 [2.0] 7 [2.4] 5 [2.2] 2 [2.5]
Artery, Thrombosis 1 [4.0]
Salivary Glands (50) (48) (50) (50)
Hyperplasia 1 [4.0]
Stomach, Forestomach (50) (48) (50) (50)
Hyperplasia, Squamous 1 [2.0] 1 [4.0]
Ulcer 3 [3.7] 1 [3.0] 6 [3.2] 6 [3.8]
Stomach, Glandular (50) (48) (50) (50)
Erosion 1 [2.0] 1 [3.0] 2 [2.0] 3 [2.0]
Ulcer 1 [4.0]
Serosa, Fibrosis 1 [2.0]
Tongue (1) (1)
Epithelium, Hyperplasia 1 [2.0] 1 [3.0]
Tooth (1)
Peridontal Tissue, Inflammation 1 [4.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (50) (50)
Cardiomyopathy 14 [2.0] 9 [2.3] 12 [2.2] 8 [2.0]
Atrium, Thrombosis 2 [4.0] 4 [4.0] 3 [2.7] 1 [4.0]
Myocardium, Mineralization 1 [2.0]
Pericardium, Fibrosis 1 [3.0]
Pericardium, Inflammation, Chronic 1 [4.0]
Valve, Inflammation, Suppurative 1 [4.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (48) (50) (50)
Atrophy 1 [4.0] 1 [3.0]
Hyperplasia 1 [3.0]
Necrosis 1 [2.0]
Vacuolization Cytoplasmic 7 [1.9] 3 [2.7] 6 [1.7] 3 [2.0]
Adrenal Medulla (50) (48) (50) (50)
Atrophy 1 [4.0]
Hemorrhage 1 [4.0]
Hyperplasia 13 [2.2] 18 [2.8] 18 [2.3] 24 [2.8]
Thrombosis 1 [4.0]
Islets, Pancreatic (50) (48) (50) (50)
Hyperplasia 1 [4.0] 1 [4.0]
Parathyroid Gland (49) (48) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 09:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 [3.0]
Pituitary Gland (50) (49) (50) (50)
Angiectasis 1 [4.0]
Atrophy 1 [4.0]
Cyst 1 [4.0] 1 [4.0] 1 [2.0]
Hemorrhage 4 [3.5] 1 [4.0] 1 [3.0]
Hyperplasia 8 [3.8] 8 [3.1] 9 [3.3] 9 [3.8]
Thyroid Gland (50) (48) (50) (50)
C-Cell, Hyperplasia 4 [1.8] 3 [1.7] 5 [1.8] 1 [2.0]
Follicle, Cyst 1 [2.0] 1 [2.0] 1 [4.0]
Follicular Cell, Hyperplasia 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (50) (49) (50) (50)
Cyst 1 [2.0] 2 [4.0]
Hyperplasia 1 [4.0] 2 [3.5] 3 [3.7]
Inflammation, Granulomatous 1 [2.0]
Inflammation, Suppurative 1 [3.0]
Prostate (50) (49) (50) (50)
Inflammation, Suppurative 3 [3.0] 1 [2.0] 2 [2.5]
Seminal Vesicle (50) (49) (50) (50)
Hyperplasia 1 [3.0]
Testes (50) (50) (50) (50)
Germinal Epithelium, Atrophy 10 [3.7] 8 [3.8] 8 [3.5] 15 [3.7]
Interstitial Cell, Hyperplasia 4 [3.0] 3 [3.0] 1 [3.0] 3 [3.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (50)
Hyperplasia, Reticulum Cell 1 [4.0]
Myelofibrosis 1 [3.0]
Lymph Node (7) (7) (12) (15)
Infiltration Cellular, Histiocyte 1 [3.0]
Deep Cervical, Hemorrhage 1 [3.0]
Deep Cervical, Infiltration Cellular,
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 09:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Histiocyte 1 [2.0]
Deep Cervical, Pigmentation 1 [2.0]
Pancreatic, Ectasia 2 [3.5]
Pancreatic, Pigmentation 1 [3.0]
Renal, Ectasia 1 [3.0]
Lymph Node, Bronchial (11) (13) (12) (7)
Angiectasis 1 [4.0]
Ectasia 3 [3.7] 2 [4.0] 1 [3.0]
Hemorrhage 1 [3.0]
Infiltration Cellular, Histiocyte 1 [2.0] 1 [2.0]
Pigmentation 1 [3.0] 1 [1.0]
Lymph Node, Mesenteric (50) (48) (50) (50)
Hyperplasia, Lymphoid 1 [4.0] 1 [3.0]
Lymph Node, Mediastinal (41) (44) (46) (44)
Angiectasis 1 [3.0]
Hemorrhage 1 [4.0]
Hyperplasia, Lymphoid 1 [3.0] 1 [4.0]
Infiltration Cellular, Histiocyte 1 [4.0]
Pigmentation 1 [1.0] 1 [4.0]
Spleen (50) (50) (50) (50)
Accessory Spleen 2 1 1
Fibrosis 2 [3.0] 5 [2.8] 3 [3.0] 8 [3.6]
Hemorrhage 2 [4.0] 2 [4.0] 2 [4.0] 1 [4.0]
Necrosis 4 [4.0] 4 [4.0] 6 [4.0] 4 [4.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (49) (50) (50)
Galactocele 5 [3.0] 1 [3.0] 3 [4.0]
Skin (50) (49) (50) (50)
Cyst Epithelial Inclusion 3 [4.0] 3 [4.0] 4 [4.0]
Hyperkeratosis 1 [4.0] 1 [4.0] 1 [4.0] 3 [2.3]
Hyperplasia, Focal, Squamous 1 [2.0]
Inflammation, Acute 1 [2.0]
Inflammation, Granulomatous 1 [3.0] 2 [2.5]
Sebaceous Gland, Hyperplasia 1 [3.0]
Subcutaneous Tissue, Fibrosis 1 [3.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 09:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Hyperostosis 1 [2.0]
Cranium, Maxilla, Fracture 1 [4.0]
Tibia, Fracture 1
Skeletal Muscle (3) (3) (4) (6)
Hemorrhage 1 [2.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (50) (50)
Compression 8 [3.4] 8 [3.0] 3 [2.3] 6 [2.8]
Hemorrhage 5 [3.8] 3 [3.7] 6 [3.2] 4 [3.5]
Spinal Cord (2) (3) (5) (5)
Gliosis 1 [2.0]
Inflammation 1 [3.0]
Neuron, Degeneration 1 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (48) (50) (50)
Foreign Body 2 [4.0] 3 [4.0] 6 [3.7] 4 [4.0]
Inflammation, Suppurative 2 [2.5] 2 [1.5] 2 [1.5]
Epiglottis, Hyperplasia 1 [2.0]
Epiglottis, Metaplasia, Squamous 1 [2.0]
Lung (50) (49) (50) (50)
Hemorrhage 2 [2.5] 5 [3.2] 5 [2.6]
Inflammation, Chronic 4 [2.0] 2 [1.5]
Inflammation, Suppurative 2 [2.5] 1 [2.0]
Thrombosis 1 [3.0]
Alveolar Epithelium, Hyperplasia 4 [1.8] 7 [2.0] 4 [1.8] 4 [2.0]
Alveolar Epithelium, Metaplasia, Squamous 1 [1.0]
Alveolus, Emphysema 2 [2.5]
Alveolus, Infiltration Cellular, Histiocyte 10 [1.9] 5 [2.0] 6 [1.8] 6 [2.0]
Alveolus, Pigmentation 1 [3.0]
Bronchiole, Hyperplasia 1 [3.0]
Bronchiole, Alveolus, Foreign Body 1 [3.0]
Interstitium, Fibrosis 2 [2.5] 3 [1.7] 1 [1.0]
Nose (50) (49) (50) (50)
Foreign Body 1 [3.0] 3 [3.0] 4 [3.0] 7 [3.0]
Inflammation, Suppurative 4 [2.0] 8 [1.9] 4 [1.8] 10 [1.3]
Goblet Cell, Hyperplasia 1 [2.0] 1 [1.0] 5 [2.4]
Nasolacrimal Duct, Inflammation, Suppurative 1 [2.0] 1 [2.0] 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 97006-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 05/11/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 09:05:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Respiratory Epithelium, Hyperplasia 4 [2.3] 1 [1.0] 3 [2.0] 3 [2.0]
Pleura (50) (49) (50) (50)
Fibrosis 3 [1.7]
Inflammation, Chronic 6 [1.8] 6 [1.5] 4 [1.5]
Mesothelium, Hyperplasia 1 [2.0] 1 [4.0]
Trachea (50) (48) (50) (50)
Inflammation, Suppurative 2 [2.5]
Epithelium, Hyperplasia 1 [4.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (45) (46) (48)
Anterior Chamber, Hemorrhage 1 [3.0]
Anterior Chamber, Inflammation, Suppurative 1 [2.0]
Cornea, Hyperplasia 1 [2.0]
Lens, Cataract 7 [2.7] 6 [2.7] 3 [2.7] 2 [3.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Infarct 4 3
Nephropathy 42 [2.0] 45 [2.6] 47 [2.4] 50 [3.1]
Papilla, Mineralization 1 [1.0] 6 [1.2] 22 [1.6] 29 [1.5]
Pelvis, Dilatation 1 [1.0]
Pelvis, Transitional Epithelium, Hyperplasia 1 [1.0] 5 [1.8] 6 [1.2] 19 [1.4]
Renal Tubule, Accumulation, Hyaline Droplet 2 [1.5] 2 [1.0]
Renal Tubule, Cyst 1 1 1
Renal Tubule, Hyperplasia 1 [2.0] 11 [3.2] 3 [2.0] 18 [2.7]
Renal Tubule, Pigmentation 1 [3.0]
Transitional Epithelium, Hyperplasia 1 [3.0]
Urinary Bladder (50) (48) (50) (50)
Calculus Micro Observation Only 1 [2.0] 2 [3.0] 2 [2.0]
Transitional Epithelium, Hyperplasia 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 12
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