TDMS Study 97006-02 Pathology Tables
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:39:58
FINAL#1 MICE
Facility: Battelle Northwest
Chemical CAS #: 108-10-1
Lock Date: 01/24/03
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:39:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 10 9 6 9
Natural Death 5 3 5 3
Accidently Killed 1
Survivors
Terminal Sacrifice 35 37 39 38
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (48) (49) (49)
Artery, Inflammation, Chronic Active 1 (2%)
Intestine Large, Rectum (47) (48) (48) (49)
Artery, Inflammation, Chronic Active 1 (2%)
Intestine Large, Cecum (46) (48) (47) (49)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Intestine Small, Duodenum (47) (48) (47) (48)
Ulcer 1 (2%)
Peyer's Patch, Hyperplasia 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 3 (6%) 2 (4%) 1 (2%) 3 (6%)
Clear Cell Focus 3 (6%) 4 (8%) 5 (10%) 2 (4%)
Cyst 1 (2%)
Eosinophilic Focus 4 (8%) 11 (22%) 10 (20%) 14 (28%)
Fatty Change 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Infarct 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%)
Mixed Cell Focus 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Necrosis 3 (6%) 1 (2%) 5 (10%) 1 (2%)
Tension Lipidosis 1 (2%) 2 (4%) 3 (6%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Mesentery (11) (11) (13) (8)
Artery, Inflammation, Chronic Active 1 (9%)
Fat, Hemorrhage 1 (9%)
Fat, Necrosis 9 (82%) 9 (82%) 11 (85%) 7 (88%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:39:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (50) (50) (49) (50)
Atrophy 3 (6%) 1 (2%)
Basophilic Focus 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Necrosis, Fatty 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Duct, Cyst 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (50)
Atrophy 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia, Squamous 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Inflammation 1 (2%) 2 (4%)
Artery, Inflammation, Chronic Active 2 (4%)
Stomach, Glandular (49) (50) (48) (49)
Metaplasia, Hepatocyte 1 (2%)
Necrosis 1 (2%)
Artery, Inflammation, Chronic Active 2 (4%)
Tooth (1) (1)
Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 3 (6%) 6 (12%) 5 (10%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 4 (8%) 3 (6%) 1 (2%) 2 (4%)
Hypertrophy 3 (6%) 3 (6%) 3 (6%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Necrosis 1 (2%)
Adrenal Medulla (50) (50) (49) (49)
Hyperplasia 2 (4%) 2 (4%) 1 (2%)
Islets, Pancreatic (50) (50) (49) (50)
Hyperplasia 2 (4%) 1 (2%)
Pituitary Gland (50) (49) (48) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:39:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Angiectasis 1 (2%) 3 (6%) 3 (6%) 2 (4%)
Pars Distalis, Hyperplasia 10 (20%) 8 (16%) 13 (27%) 11 (22%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (49) (48)
Cyst 1 (2%)
Follicular Cell, Hyperplasia 7 (14%) 5 (10%) 11 (22%) 8 (17%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2) (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (49) (50) (48) (50)
Angiectasis 1 (2%)
Cyst 14 (29%) 13 (26%) 13 (27%) 9 (18%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Uterus (50) (50) (49) (50)
Amyloid Deposition 1 (2%)
Angiectasis 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Hyperplasia, Cystic 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia, Cystic 49 (98%) 48 (96%) 46 (94%) 49 (98%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50)
Infiltration Cellular, Mast Cell 1 (2%)
Lymph Node (7) (3) (9) (5)
Iliac, Ectasia 1 (33%)
Iliac, Infiltration Cellular, Plasma Cell 1 (14%)
Lumbar, Angiectasis 1 (33%)
Lumbar, Ectasia 1 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:39:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lumbar, Infiltration Cellular, Plasma Cell 1 (20%)
Renal, Angiectasis 1 (33%) 1 (11%)
Renal, Ectasia 1 (14%)
Renal, Infiltration Cellular, Plasma Cell 1 (20%)
Renal, Artery, Inflammation, Chronic Active 1 (33%)
Lymph Node, Mandibular (40) (42) (39) (38)
Hyperplasia, Lymphoid 2 (5%)
Infiltration Cellular, Plasma Cell 1 (3%)
Lymph Node, Mesenteric (50) (49) (49) (47)
Angiectasis 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mediastinal (46) (40) (38) (41)
Hyperplasia, Lymphoid 1 (3%)
Infiltration Cellular, Mast Cell 1 (2%)
Spleen (50) (50) (49) (50)
Hematopoietic Cell Proliferation 5 (10%) 1 (2%) 7 (14%) 5 (10%)
Infiltration Cellular, Mast Cell 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (50) (49)
Hyperplasia 1 (2%)
Skin (50) (50) (50) (50)
Foreign Body 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 2 (4%) 2 (4%) 5 (10%) 2 (4%)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fracture 1 (2%)
Hyperostosis 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Skeletal Muscle (1) (2) (3) (2)
Inflammation, Suppurative 1 (50%)
Artery, Inflammation, Chronic Active 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:39:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Brain (50) (50) (50) (50)
Meninges, Infiltration Cellular, Mononuclear
Cell 1 (2%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (49) (50)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 1 (2%)
Lung (50) (50) (50) (50)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 5 (10%) 3 (6%) 5 (10%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 2 (4%)
Artery, Mineralization 1 (2%)
Bronchiole, Hyperplasia 4 (8%) 2 (4%)
Nose (50) (50) (50) (49)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Suppurative 4 (8%) 3 (6%) 2 (4%)
Artery, Inflammation, Chronic Active 1 (2%)
Glands, Hyperplasia 23 (46%) 30 (60%) 23 (46%) 20 (41%)
Olfactory Epithelium, Atrophy 1 (2%) 1 (2%)
Olfactory Epithelium, Degeneration, Hyaline 8 (16%) 5 (10%) 4 (8%) 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 24 (48%) 19 (38%) 20 (40%) 13 (27%)
Respiratory Epithelium, Metaplasia 3 (6%) 3 (6%) 6 (12%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Turbinate, Necrosis 2 (4%)
Trachea (50) (50) (49) (50)
Degeneration, Hyaline 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (48) (49) (50)
Cataract 1 (2%)
Degeneration 1 (2%)
Cornea, Inflammation, Chronic Active 1 (2%) 1 (2%) 3 (6%) 2 (4%)
Cornea, Mineralization 1 (2%)
Retina, Atrophy 1 (2%)
Harderian Gland (49) (49) (49) (50)
Hyperplasia 1 (2%) 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:39:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Amyloid Deposition 1 (2%)
Cyst 1 (2%)
Metaplasia, Osseous 2 (4%) 2 (4%) 3 (6%) 2 (4%)
Nephropathy 22 (44%) 28 (56%) 26 (53%) 27 (54%)
Artery, Inflammation, Chronic Active 1 (2%)
Papilla, Necrosis 1 (2%) 1 (2%)
Pelvis, Dilatation 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (50) (50) (49) (50)
Artery, Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:39:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 9 6 12 9
Natural Death 1 2 3 4
Survivors
Terminal Sacrifice 40 42 34 37
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (43) (44) (39) (45)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Intestine Large, Rectum (50) (48) (49) (49)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%)
Intestine Large, Cecum (49) (48) (47) (47)
Hemorrhage 1 (2%)
Intestine Small, Duodenum (49) (48) (45) (47)
Ulcer 1 (2%)
Intestine Small, Jejunum (49) (48) (47) (47)
Cyst 1 (2%)
Peyer's Patch, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Intestine Small, Ileum (49) (48) (48) (47)
Inflammation, Acute 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 8 (16%) 5 (10%) 4 (8%) 8 (16%)
Clear Cell Focus 22 (44%) 13 (26%) 13 (26%) 20 (40%)
Eosinophilic Focus 3 (6%) 4 (8%) 5 (10%) 8 (16%)
Hepatodiaphragmatic Nodule 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Mixed Cell Focus 1 (2%) 1 (2%) 1 (2%)
Necrosis 5 (10%) 1 (2%) 2 (4%) 7 (14%)
Tension Lipidosis 4 (8%) 3 (6%) 3 (6%) 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:39:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Erythrophagocytosis 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 1 (2%) 2 (4%) 1 (2%)
Mesentery (9) (3) (3) (4)
Fat, Necrosis 9 (100%) 3 (100%) 3 (100%) 3 (75%)
Salivary Glands (50) (50) (48) (50)
Inflammation, Acute 1 (2%)
Stomach, Forestomach (50) (49) (49) (50)
Hyperplasia, Squamous 3 (6%) 3 (6%) 2 (4%) 1 (2%)
Inflammation 1 (2%) 2 (4%) 3 (6%)
Ulcer 2 (4%) 1 (2%) 2 (4%)
Stomach, Glandular (49) (49) (49) (49)
Hyperplasia 1 (2%)
Necrosis 1 (2%) 1 (2%)
Tooth (1)
Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 10 (20%) 8 (16%) 2 (4%) 10 (20%)
Inflammation, Suppurative 1 (2%)
Thrombosis 2 (4%) 3 (6%) 1 (2%)
Artery, Inflammation, Chronic Active 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Hyperplasia 13 (26%) 18 (36%) 13 (27%) 9 (18%)
Hypertrophy 26 (52%) 30 (60%) 26 (53%) 14 (28%)
Adrenal Medulla (50) (50) (49) (50)
Hyperplasia 1 (2%) 1 (2%) 3 (6%)
Islets, Pancreatic (49) (50) (49) (50)
Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Pituitary Gland (50) (47) (48) (49)
Pars Distalis, Hyperplasia 1 (2%) 2 (4%)
Thyroid Gland (50) (49) (50) (50)
Follicular Cell, Hyperplasia 4 (8%) 4 (8%) 6 (12%) 8 (16%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:39:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 2 (4%) 2 (4%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Granulomatous 1 (2%)
Penis (1) (1) (1)
Inflammation, Acute 1 (100%) 1 (100%)
Preputial Gland (50) (50) (50) (50)
Ectasia 2 (4%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
Prostate (50) (49) (49) (50)
Inflammation, Suppurative 1 (2%) 1 (2%)
Seminal Vesicle (50) (50) (49) (50)
Dilatation 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Thrombosis 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Bronchial (39) (35) (37) (39)
Hyperplasia, Lymphoid 1 (3%)
Lymph Node, Mandibular (37) (36) (32) (34)
Hyperplasia, Lymphoid 1 (3%)
Lymph Node, Mesenteric (49) (48) (48) (48)
Infiltration Cellular, Histiocyte 1 (2%)
Lymph Node, Mediastinal (42) (38) (36) (38)
Hyperplasia, Lymphoid 1 (3%)
Spleen (50) (50) (49) (49)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (49) (50)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:39:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Atrophy 1 (2%)
Hyperostosis 1 (2%)
Joint, Cartilage, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%)
Necrosis 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion, Chronic 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 1 (2%)
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 7 (14%) 5 (10%) 5 (10%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 3 (6%)
Bronchiole, Hyperplasia 1 (2%) 2 (4%) 3 (6%) 2 (4%)
Nose (50) (50) (50) (50)
Hyperplasia 1 (2%)
Inflammation, Suppurative 4 (8%) 1 (2%) 3 (6%) 2 (4%)
Glands, Hyperplasia 33 (66%) 32 (64%) 24 (48%) 26 (52%)
Olfactory Epithelium, Atrophy 1 (2%)
Olfactory Epithelium, Degeneration, Hyaline 1 (2%) 1 (2%) 2 (4%)
Olfactory Epithelium, Necrosis 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 1 (2%) 3 (6%)
Respiratory Epithelium, Hyperplasia 1 (2%)
Respiratory Epithelium, Metaplasia 9 (18%) 11 (22%) 13 (26%) 6 (12%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (48) (49) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC METHYL ISOBUTYL KETONE Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 07:39:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Cataract 1 (2%)
Degeneration 1 (2%) 1 (2%)
Cornea, Inflammation, Acute 1 (2%)
Cornea, Inflammation, Chronic Active 2 (4%)
Cornea, Mineralization 1 (2%)
Retina, Atrophy 1 (2%)
Harderian Gland (50) (49) (50) (50)
Hyperplasia 3 (6%) 4 (8%) 1 (2%) 2 (4%)
Hypertrophy 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Cyst 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Metaplasia, Osseous 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Nephropathy 41 (82%) 45 (90%) 40 (82%) 43 (86%)
Renal Tubule, Hyperplasia 2 (4%) 2 (4%) 1 (2%)
Urinary Bladder (50) (49) (49) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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