https://ntp.niehs.nih.gov/go/6851

TDMS Study 97006-02 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                  METHYL ISOBUTYL KETONE                                DATE: 04/29/04       
EXPERIMENT: 97006 TEST: 02                                                                                     TIME: 07:52:12       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05452                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C97006       
PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: 108-10-1        
------------------------------------------------------------------------------------------------------------------------------------
                                                            FINAL#1 MICE                                                            
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                  METHYL ISOBUTYL KETONE                                DATE: 04/29/04       
EXPERIMENT: 97006 TEST: 02                                                                                     TIME: 07:52:12       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05452                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C97006       
PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: 108-10-1        
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                 METHYL ISOBUTYL KETONE                                                                           
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hypertrophy                                                                                  
Brain                                  Necrosis                                                                                     
Heart                                  Cardiomyopathy                                                                               
Heart: Artery                          Inflammation Chronic                                                                         
Liver                                  Clear Cell Focus                                                                             
                                       Eosinophilic Focus                                                                           
Mesentery: Fat                         Necrosis                                                                                     
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Liver                                  Eosinophilic Focus                                                                           
Nose                                   Inflammation                                                                                 
Nose: Olfactory Epithelium             Degeneration Hyaline                                                                         
Nose: Respiratory Epithelium           Degeneration Hyaline                                                                         
Pancreas                               Atrophy                                                                                      
Stomach, Forestomach: Artery           Inflammation Chronic                                                                         
Stomach, Glandular: Artery             Inflammation Chronic                                                                         
===============================================================                                                                     
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE                    
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  18/50 (36%)  13/49 (27%)  9/50 (18%)  |4/50 (8%)    3/50 (6%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     13/46.97     18/47.79     13/43.29     9/45.81     |4/44.99      3/46.04      1/45.87      2/46.46      | 
|POLY-3 PERCENT (g) |     27.7%        37.7%        30.0%        19.7%       |8.9%         6.5%         2.2%         4.3%         | 
|TERMINAL (d)       |     12/40 (30%)  16/42 (38%)  11/35 (31%)  8/37 (22%)  |4/35 (11%)   2/37 (5%)    1/39 (3%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     598          680          471          593         |731 (T)      687          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.173N     P=0.242      P=0.439      P=0.299N    |P=0.194N     P=0.472N     P=0.148N     P=0.299N     | 
|POLY 3             |     P=0.122N     P=0.206      P=0.494      P=0.253N    |P=0.215N     P=0.487N     P=0.173N     P=0.323N     | 
|POLY 1.5           |     P=0.115N     P=0.200      P=0.511      P=0.246N    |P=0.217N     P=0.493N     P=0.175N     P=0.327N     | 
|POLY 6             |     P=0.130N     P=0.219      P=0.484      P=0.259N    |P=0.212N     P=0.483N     P=0.170N     P=0.315N     | 
|LOGISTIC REGRESSION|     P=0.124N     P=0.224      P=0.507      P=0.257N    |P=0.199N     P=0.487N     P=0.148N     P=0.299N     | 
|COCH-ARM / FISHERS |     P=0.103N     P=0.194      P=0.567      P=0.235N    |P=0.221N     P=0.500N     P=0.181N     P=0.339N     | 
|ORDER RESTRICTED   |     P=0.122N     (e)          (e)          (e)         |P=0.184N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/50 (52%)  30/50 (60%)  26/49 (53%)  14/50 (28%) |3/50 (6%)    0/50 (0%)    3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     26/46.97     30/48.16     26/44.78     14/45.54    |3/44.99      0/45.87      3/45.87      3/46.86      | 
|POLY-3 PERCENT (g) |     55.4%        62.3%        58.1%        30.7%       |6.7%         0.0%         6.5%         6.4%         | 
|TERMINAL (d)       |     25/40 (63%)  27/42 (64%)  21/35 (60%)  13/37 (35%) |3/35 (9%)    0/37 (0%)    3/39 (8%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     598          661          471          678         |731 (T)      ---          731 (T)      617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.011N*    P=0.367      P=0.314      P=0.020N*   |P=0.418      P=0.111N     P=0.613N     P=0.627N     | 
|POLY 3             |     P=0.003N**   P=0.314      P=0.480      P=0.012N*   |P=0.400      P=0.115N     P=0.653N     P=0.643N     | 
|POLY 1.5           |     P=0.003N**   P=0.293      P=0.479      P=0.012N*   |P=0.396      P=0.117N     P=0.657N     P=0.650N     | 
|POLY 6             |     P=0.004N**   P=0.356      P=0.498      P=0.012N*   |P=0.409      P=0.114N     P=0.650N     P=0.633N     | 
|LOGISTIC REGRESSION|     P=0.005N**   P=0.344      P=0.402      P=0.014N*   |P=0.399      (e)          P=0.613N     P=0.655N     | 
|COCH-ARM / FISHERS |     P=0.003N**   P=0.273      P=0.538      P=0.012N*   |P=0.387      P=0.121N     P=0.661N     P=0.661N     | 
|ORDER RESTRICTED   |     P=0.003N**   (e)          (e)          (e)         |P=0.383      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 2       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/49 (6%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    1/49 (2%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/46.53      1/47.60      3/41.95      0/45.34     |2/44.99      2/45.87      1/45.18      0/45.46      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         7.2%         0.0%        |4.5%         4.4%         2.2%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    0/42 (0%)    2/35 (6%)    0/37 (0%)   |2/35 (6%)    2/37 (5%)    0/38 (0%)    0/37 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      704          701          ---         |731 (T)      731 (T)      648          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.440N     P=0.747N     P=0.263      P=0.516N    |P=0.118N     P=0.675N     P=0.476N     P=0.226N     | 
|POLY 3             |     P=0.425N     P=0.755N     P=0.269      P=0.505N    |P=0.125N     P=0.687N     P=0.499N     P=0.235N     | 
|POLY 1.5           |     P=0.419N     P=0.758N     P=0.276      P=0.503N    |P=0.127N     P=0.690N     P=0.502N     P=0.237N     | 
|POLY 6             |     P=0.432N     P=0.752N     P=0.265      P=0.507N    |P=0.123N     P=0.686N     P=0.495N     P=0.231N     | 
|LOGISTIC REGRESSION|     P=0.427N     P=0.760N     P=0.263      (e)         |P=0.126N     P=0.675N     P=0.506N     (e)          | 
|COCH-ARM / FISHERS |     P=0.410N     P=0.753N     P=0.301      P=0.500N    |P=0.129N     P=0.691N     P=0.508N     P=0.253N     | 
|ORDER RESTRICTED   |     P=0.218N     (e)          (e)          (e)         |P=0.153N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/47.33      0/47.50      0/42.28      0/45.34     |0/44.99      0/45.87      0/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     4.2%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     612          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.128N     P=0.240N     P=0.276N     P=0.257N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.117N     P=0.236N     P=0.263N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.116N     P=0.237N     P=0.255N     P=0.243N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.118N     P=0.235N     P=0.271N     P=0.251N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.089N     P=0.245N     P=0.163N     P=0.163N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.033N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 3       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain: Meninges                                                                                                                  | 
|     Infiltration Cellular Mononuclear Cell                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.53      0/47.50      0/42.28      0/45.34     |0/44.99      1/45.87      2/45.87      2/46.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         4.4%         4.3%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    1/37 (3%)    2/39 (5%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          731 (T)      731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.174      P=0.511      P=0.262      P=0.257      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.169      P=0.504      P=0.242      P=0.244      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.167      P=0.502      P=0.240      P=0.242      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.174      P=0.505      P=0.243      P=0.248      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          P=0.511      P=0.262      P=0.257      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.160      P=0.500      P=0.247      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.158      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Granuloma Sperm                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.97      0/47.50      2/42.33      1/45.34     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         4.7%         2.2%        |                                                    | 
|TERMINAL (d)       |     1/40 (3%)    0/42 (0%)    1/35 (3%)    1/37 (3%)   |                                                    | 
|FIRST INCIDENCE    |     598          ---          717          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.561N     P=0.239N     P=0.642      P=0.525N    |                                                    | 
|POLY 3             |     P=0.546N     P=0.235N     P=0.656      P=0.512N    |                                                    | 
|POLY 1.5           |     P=0.540N     P=0.236N     P=0.667      P=0.507N    |                                                    | 
|POLY 6             |     P=0.553N     P=0.233N     P=0.647      P=0.517N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.532N     P=0.249N     P=0.693      P=0.481N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.531N     P=0.247N     P=0.691N     P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.431N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 4       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/48 (4%)    0/49 (0%)    0/49 (0%)   |1/49 (2%)    1/48 (2%)    3/49 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.24      2/45.94      0/41.84      0/44.78     |1/44.41      1/45.52      3/45.40      2/46.46      | 
|POLY-3 PERCENT (g) |     0.0%         4.4%         0.0%         0.0%        |2.3%         2.2%         6.6%         4.3%         | 
|TERMINAL (d)       |     0/40 (0%)    2/42 (5%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    1/37 (3%)    2/39 (5%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |715          731 (T)      648          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.428N     P=0.249      (e)          (e)         |P=0.352      P=0.751N     P=0.334      P=0.531      | 
|POLY 3             |     P=0.414N     P=0.236      (e)          (e)         |P=0.341      P=0.755N     P=0.313      P=0.516      | 
|POLY 1.5           |     P=0.411N     P=0.234      (e)          (e)         |P=0.339      P=0.757N     P=0.310      P=0.513      | 
|POLY 6             |     P=0.415N     P=0.240      (e)          (e)         |P=0.346      P=0.755N     P=0.316      P=0.519      | 
|LOGISTIC REGRESSION|     (e)          P=0.249      (e)          (e)         |P=0.339      P=0.756N     P=0.306      P=0.523      | 
|COCH-ARM / FISHERS |     P=0.404N     P=0.242      (e)          (e)         |P=0.335      P=0.747      P=0.309      P=0.508      | 
|ORDER RESTRICTED   |     P=0.252N     (e)          (e)          (e)         |P=0.339      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/49 (8%)    1/50 (2%)    2/50 (4%)   |1/49 (2%)    1/49 (2%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/46.53      4/47.54      1/42.28      2/45.34     |1/44.34      1/45.60      2/45.09      1/46.46      | 
|POLY-3 PERCENT (g) |     6.5%         8.4%         2.4%         4.4%        |2.3%         2.2%         4.4%         2.2%         | 
|TERMINAL (d)       |     3/40 (8%)    2/42 (5%)    1/35 (3%)    2/37 (5%)   |1/35 (3%)    0/37 (0%)    2/39 (5%)    1/38 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      493          729 (T)      729 (T)     |731 (T)      710          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.334N     P=0.526      P=0.354N     P=0.536N    |P=0.618      P=0.748N     P=0.538      P=0.743N     | 
|POLY 3             |     P=0.310N     P=0.512      P=0.340N     P=0.512N    |P=0.605      P=0.754N     P=0.506      P=0.750N     | 
|POLY 1.5           |     P=0.303N     P=0.502      P=0.331N     P=0.507N    |P=0.603      P=0.757N     P=0.503      P=0.752N     | 
|POLY 6             |     P=0.317N     P=0.526      P=0.348N     P=0.516N    |P=0.610      P=0.753N     P=0.508      P=0.748N     | 
|LOGISTIC REGRESSION|     P=0.293N     P=0.465      P=0.354N     P=0.536N    |P=0.612      P=0.757N     P=0.538      P=0.743N     | 
|COCH-ARM / FISHERS |     P=0.289N     P=0.489      P=0.309N     P=0.500N    |P=0.597      P=0.753N     P=0.500      P=0.747N     | 
|ORDER RESTRICTED   |     P=0.315N     (e)          (e)          (e)         |P=0.594      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 5       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  8/50 (16%)   2/50 (4%)    10/50 (20%) |3/50 (6%)    6/50 (12%)   5/50 (10%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     10/46.90     8/47.75      2/42.40      10/46.15    |3/45.12      6/46.27      5/46.02      3/46.51      | 
|POLY-3 PERCENT (g) |     21.3%        16.8%        4.7%         21.7%       |6.7%         13.0%        10.9%        6.5%         | 
|TERMINAL (d)       |     9/40 (23%)   7/42 (17%)   1/35 (3%)    7/37 (19%)  |1/35 (3%)    4/37 (11%)   4/39 (10%)   2/38 (5%)    | 
|FIRST INCIDENCE    |     622          661          698          593         |715          638          695          719          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.489      P=0.355N     P=0.029N*    P=0.530     |P=0.399N     P=0.269      P=0.403      P=0.615N     | 
|POLY 3             |     P=0.548      P=0.381N     P=0.022N*    P=0.583     |P=0.429N     P=0.254      P=0.367      P=0.648N     | 
|POLY 1.5           |     P=0.549N     P=0.389N     P=0.019N*    P=0.588     |P=0.435N     P=0.250      P=0.363      P=0.652N     | 
|POLY 6             |     P=0.539      P=0.368N     P=0.024N*    P=0.582     |P=0.419N     P=0.258      P=0.371      P=0.642N     | 
|LOGISTIC REGRESSION|     P=0.543      P=0.376N     P=0.024N*    P=0.581     |P=0.429N     P=0.249      P=0.370      P=0.641N     | 
|COCH-ARM / FISHERS |     P=0.527N     P=0.398N     P=0.014N*    P=0.598N    |P=0.449N     P=0.243      P=0.357      P=0.661N     | 
|ORDER RESTRICTED   |     P=0.241N     (e)          (e)          (e)         |P=0.427N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.63      0/47.50      3/42.56      1/45.68     |0/44.99      0/45.87      0/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         7.1%         2.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     704          ---          698          637         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.580N     P=0.227N     P=0.451      P=0.514N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.570N     P=0.233N     P=0.459      P=0.507N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.564N     P=0.235N     P=0.470      P=0.505N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.575N     P=0.230N     P=0.452      P=0.509N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.555N     P=0.234N     P=0.463      P=0.486N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.556N     P=0.247N     P=0.500      P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.406      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 6       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Artery                                                                                                                    | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.53      0/47.50      0/42.28      0/45.34     |1/45.86      2/46.20      0/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         0.0%         0.0%        |2.2%         4.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/40 (5%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    1/37 (3%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |368          638          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.126N     P=0.228N     P=0.268N     P=0.256N    |P=0.183N     P=0.509      P=0.500N     P=0.500N     | 
|POLY 3             |     P=0.118N     P=0.233N     P=0.259N     P=0.243N    |P=0.187N     P=0.503      P=0.500N     P=0.497N     | 
|POLY 1.5           |     P=0.116N     P=0.235N     P=0.253N     P=0.241N    |P=0.187N     P=0.501      P=0.500N     P=0.498N     | 
|POLY 6             |     P=0.120N     P=0.229N     P=0.264N     P=0.245N    |P=0.185N     P=0.505      P=0.499N     P=0.495N     | 
|LOGISTIC REGRESSION|     P=0.126N     (e)          (e)          (e)         |P=0.205N     P=0.513      P=0.455N     P=0.678N     | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.188N     P=0.500      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.031N*    (e)          (e)          (e)         |P=0.167N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum: Peyer's Patch                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/48 (2%)    2/47 (4%)    0/47 (0%)   |0/48 (0%)    0/47 (0%)    0/47 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/46.24      1/45.94      2/40.28      0/44.13     |0/43.44      0/44.66      0/43.58      0/45.43      | 
|POLY-3 PERCENT (g) |     2.2%         2.2%         5.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    1/42 (2%)    2/34 (6%)    0/37 (0%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.400N     P=0.751N     P=0.443      P=0.516N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.383N     P=0.759      P=0.452      P=0.509N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.381N     P=0.757      P=0.461      P=0.509N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.384N     P=0.758N     P=0.447      P=0.509N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.400N     P=0.751N     P=0.443      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.378N     P=0.747      P=0.484      P=0.510N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.263N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 7       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.24      2/47.50      0/41.84      1/45.34     |0/44.99      0/45.87      2/45.09      1/46.49      | 
|POLY-3 PERCENT (g) |     2.2%         4.2%         0.0%         2.2%        |0.0%         0.0%         4.4%         2.2%         | 
|TERMINAL (d)       |     1/40 (3%)    2/42 (5%)    0/35 (0%)    1/37 (3%)   |0/35 (0%)    0/37 (0%)    2/39 (5%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |---          ---          731 (T)      722          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.534N     P=0.517      P=0.527N     P=0.744     |P=0.264      (e)          P=0.262      P=0.521      | 
|POLY 3             |     P=0.511N     P=0.509      P=0.520N     P=0.756     |P=0.256      (e)          P=0.238      P=0.507      | 
|POLY 1.5           |     P=0.506N     P=0.508      P=0.514N     P=0.759     |P=0.253      (e)          P=0.236      P=0.504      | 
|POLY 6             |     P=0.516N     P=0.513      P=0.524N     P=0.753     |P=0.262      (e)          P=0.240      P=0.510      | 
|LOGISTIC REGRESSION|     P=0.534N     P=0.517      (e)          P=0.744     |P=0.262      (e)          P=0.262      P=0.508      | 
|COCH-ARM / FISHERS |     P=0.496N     P=0.508      P=0.500N     P=0.747N    |P=0.246      (e)          P=0.242      P=0.500      | 
|ORDER RESTRICTED   |     P=0.399N     (e)          (e)          (e)         |P=0.168      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/49 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.53      1/47.72      1/41.89      3/46.69     |0/44.99      0/45.87      0/45.09      0/46.46      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         2.4%         6.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    0/42 (0%)    0/35 (0%)    1/37 (3%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      670          717          441         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.152      P=0.747N     P=0.734      P=0.292     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.161      P=0.755N     P=0.737      P=0.307     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.162      P=0.757N     P=0.742      P=0.306     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.159      P=0.751N     P=0.734      P=0.307     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.178      P=0.758      P=0.736      P=0.410     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.163      P=0.753N     P=0.747      P=0.309     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.187      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 8       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/49 (6%)    1/50 (2%)   |2/50 (4%)    2/50 (4%)    3/49 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/46.53      2/47.50      3/42.52      1/45.34     |2/44.99      2/46.04      3/45.09      2/46.46      | 
|POLY-3 PERCENT (g) |     4.3%         4.2%         7.1%         2.2%        |4.5%         4.3%         6.7%         4.3%         | 
|TERMINAL (d)       |     2/40 (5%)    2/42 (5%)    2/35 (6%)    1/37 (3%)   |2/35 (6%)    1/37 (3%)    3/39 (8%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      501          729 (T)     |731 (T)      687          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.445N     P=0.677N     P=0.446      P=0.527N    |P=0.579N     P=0.676N     P=0.550      P=0.665N     | 
|POLY 3             |     P=0.423N     P=0.686N     P=0.459      P=0.509N    |P=0.582      P=0.686N     P=0.501      P=0.682N     | 
|POLY 1.5           |     P=0.416N     P=0.690N     P=0.466      P=0.506N    |P=0.577      P=0.689N     P=0.497      P=0.686N     | 
|POLY 6             |     P=0.430N     P=0.681N     P=0.455      P=0.512N    |P=0.590      P=0.683N     P=0.506      P=0.676N     | 
|LOGISTIC REGRESSION|     P=0.406N     P=0.677N     P=0.504      P=0.527N    |P=0.587N     P=0.688N     P=0.550      P=0.665N     | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.691N     P=0.490      P=0.500N    |P=0.567      P=0.691N     P=0.490      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.393N     (e)          (e)          (e)         |P=0.633      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     41/50 (82%)  45/50 (90%)  40/49 (82%)  43/50 (86%) |22/50 (44%)  28/50 (56%)  26/49 (53%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     41/48.92     45/49.32     40/45.99     43/48.00    |22/47.49     28/47.81     26/47.01     27/47.51     | 
|POLY-3 PERCENT (g) |     83.8%        91.2%        87.0%        89.6%       |46.3%        58.6%        55.3%        56.8%        | 
|TERMINAL (d)       |     35/40 (88%)  39/42 (93%)  30/35 (86%)  33/37 (89%) |16/35 (46%)  19/37 (51%)  21/39 (54%)  24/38 (63%)  | 
|FIRST INCIDENCE    |     482          493          412          593         |368          598          530          535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.167      P=0.411      P=0.260      P=0.208     |P=0.404      P=0.253      P=0.434      P=0.339      | 
|POLY 3             |     P=0.321      P=0.200      P=0.441      P=0.288     |P=0.248      P=0.159      P=0.251      P=0.205      | 
|POLY 1.5           |     P=0.365      P=0.195      P=0.471      P=0.319     |P=0.254      P=0.154      P=0.243      P=0.209      | 
|POLY 6             |     P=0.312      P=0.216      P=0.443      P=0.287     |P=0.248      P=0.169      P=0.263      P=0.207      | 
|LOGISTIC REGRESSION|     P=0.355      P=0.210      P=0.414      P=0.301     |P=0.274      P=0.162      P=0.245      P=0.226      | 
|COCH-ARM / FISHERS |     P=0.475      P=0.194      P=0.584N     P=0.393     |P=0.255      P=0.159      P=0.242      P=0.212      | 
|ORDER RESTRICTED   |     P=0.287      (e)          (e)          (e)         |P=0.236      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 9       
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/49 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/46.53      2/47.50      1/42.56      0/45.34     |0/44.99      0/45.87      0/45.09      1/46.46      | 
|POLY-3 PERCENT (g) |     4.3%         4.2%         2.4%         0.0%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     2/40 (5%)    2/42 (5%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    1/38 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      480          ---         |---          ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.144N     P=0.677N     P=0.538N     P=0.256N    |P=0.206      (e)          (e)          P=0.516      | 
|POLY 3             |     P=0.134N     P=0.686N     P=0.531N     P=0.243N    |P=0.203      (e)          (e)          P=0.506      | 
|POLY 1.5           |     P=0.132N     P=0.690N     P=0.525N     P=0.241N    |P=0.202      (e)          (e)          P=0.504      | 
|POLY 6             |     P=0.136N     P=0.681N     P=0.534N     P=0.245N    |P=0.205      (e)          (e)          P=0.510      | 
|LOGISTIC REGRESSION|     P=0.117N     P=0.677N     P=0.447N     (e)         |(e)          (e)          (e)          P=0.516      | 
|COCH-ARM / FISHERS |     P=0.126N     P=0.691N     P=0.508N     P=0.247N    |P=0.199      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.160N     (e)          (e)          (e)         |P=0.126      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   5/50 (10%)   4/50 (8%)    8/50 (16%)  |3/50 (6%)    2/50 (4%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     8/46.53      5/47.50      4/42.54      8/46.25     |3/44.99      2/46.32      1/45.87      3/46.46      | 
|POLY-3 PERCENT (g) |     17.2%        10.5%        9.4%         17.3%       |6.7%         4.3%         2.2%         6.5%         | 
|TERMINAL (d)       |     8/40 (20%)   5/42 (12%)   3/35 (9%)    5/37 (14%)  |3/35 (9%)    1/37 (3%)    1/39 (3%)    3/38 (8%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      659          601         |731 (T)      598          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.403      P=0.243N     P=0.248N     P=0.546     |P=0.583N     P=0.474N     P=0.267N     P=0.625N     | 
|POLY 3             |     P=0.465      P=0.262N     P=0.223N     P=0.603     |P=0.576      P=0.487N     P=0.298N     P=0.647N     | 
|POLY 1.5           |     P=0.471      P=0.269N     P=0.210N     P=0.603     |P=0.574      P=0.492N     P=0.301N     P=0.652N     | 
|POLY 6             |     P=0.461      P=0.252N     P=0.230N     P=0.607     |P=0.581      P=0.482N     P=0.296N     P=0.640N     | 
|LOGISTIC REGRESSION|     P=0.450      P=0.243N     P=0.237N     P=0.591     |P=0.579      P=0.498N     P=0.267N     P=0.625N     | 
|COCH-ARM / FISHERS |     P=0.486      P=0.277N     P=0.178N     P=0.607N    |P=0.569      P=0.500N     P=0.309N     P=0.661N     | 
|ORDER RESTRICTED   |     P=0.393      (e)          (e)          (e)         |P=0.478N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 10      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  13/50 (26%)  13/50 (26%)  20/50 (40%) |3/50 (6%)    4/50 (8%)    5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     22/46.93     13/47.50     13/42.28     20/46.61    |3/44.99      4/46.15      5/45.87      2/46.84      | 
|POLY-3 PERCENT (g) |     46.9%        27.4%        30.8%        42.9%       |6.7%         8.7%         10.9%        4.3%         | 
|TERMINAL (d)       |     21/40 (53%)  13/42 (31%)  13/35 (37%)  17/37 (46%) |3/35 (9%)    2/37 (5%)    5/39 (13%)   0/38 (0%)    | 
|FIRST INCIDENCE    |     612          729 (T)      729 (T)      551         |731 (T)      687          731 (T)      643          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.372      P=0.028N*    P=0.102N     P=0.548N    |P=0.348N     P=0.527      P=0.416      P=0.465N     | 
|POLY 3             |     P=0.503      P=0.037N*    P=0.087N     P=0.429N    |P=0.366N     P=0.514      P=0.367      P=0.482N     | 
|POLY 1.5           |     P=0.515      P=0.041N*    P=0.072N     P=0.428N    |P=0.374N     P=0.508      P=0.363      P=0.488N     | 
|POLY 6             |     P=0.495      P=0.033N*    P=0.100N     P=0.424N    |P=0.353N     P=0.519      P=0.371      P=0.471N     | 
|LOGISTIC REGRESSION|     P=0.445      P=0.027N*    P=0.092N     P=0.469N    |P=0.374N     P=0.512      P=0.416      P=0.493N     | 
|COCH-ARM / FISHERS |     P=0.540      P=0.046N*    P=0.046N*    P=0.420N    |P=0.389N     P=0.500      P=0.357      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.136N     (e)          (e)          (e)         |P=0.332N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    4/50 (8%)    5/50 (10%)   8/50 (16%)  |4/50 (8%)    11/50 (22%)  10/50 (20%)  14/50 (28%)  | 
|POLY-3 RATE (b)    |     3/46.72      4/48.03      5/42.28      8/45.34     |4/45.05      11/45.98     10/46.06     14/46.46     | 
|POLY-3 PERCENT (g) |     6.4%         8.3%         11.8%        17.6%       |8.9%         23.9%        21.7%        30.1%        | 
|TERMINAL (d)       |     2/40 (5%)    3/42 (7%)    5/35 (14%)   8/37 (22%)  |3/35 (9%)    10/37 (27%)  9/39 (23%)   14/38 (37%)  | 
|FIRST INCIDENCE    |     678          565          729 (T)      729 (T)     |715          702          684          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.037 *    P=0.524      P=0.289      P=0.080     |P=0.024 *    P=0.059      P=0.107      P=0.014 *    | 
|POLY 3             |     P=0.045 *    P=0.515      P=0.303      P=0.089     |P=0.018 *    P=0.047 *    P=0.078      P=0.009 **   | 
|POLY 1.5           |     P=0.049 *    P=0.508      P=0.318      P=0.093     |P=0.017 *    P=0.046 *    P=0.076      P=0.009 **   | 
|POLY 6             |     P=0.041 *    P=0.524      P=0.290      P=0.085     |P=0.019 *    P=0.047 *    P=0.080      P=0.010 *    | 
|LOGISTIC REGRESSION|     P=0.046 *    P=0.486      P=0.293      P=0.087     |P=0.025 *    P=0.049 *    P=0.082      P=0.015 *    | 
|COCH-ARM / FISHERS |     P=0.056      P=0.500      P=0.357      P=0.100     |P=0.016 *    P=0.045 *    P=0.074      P=0.009 **   | 
|ORDER RESTRICTED   |     P=0.061      (e)          (e)          (e)         |P=0.008 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 11      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.53      0/47.50      0/42.28      0/45.34     |0/44.99      0/45.87      2/46.30      0/46.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          648          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.608      (e)          P=0.247      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.609      (e)          P=0.244      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.605      (e)          P=0.241      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.617      (e)          P=0.247      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.589      (e)          P=0.236      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.595      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.253      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.53      0/47.50      0/42.28      1/45.34     |0/44.99      1/46.23      0/45.87      2/46.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.2%        |0.0%         2.2%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    1/37 (3%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          628          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187      (e)          (e)          P=0.484     |P=0.148      P=0.504      (e)          P=0.257      | 
|POLY 3             |     P=0.194      (e)          (e)          P=0.495     |P=0.144      P=0.505      (e)          P=0.244      | 
|POLY 1.5           |     P=0.196      (e)          (e)          P=0.497     |P=0.143      P=0.503      (e)          P=0.242      | 
|POLY 6             |     P=0.192      (e)          (e)          P=0.493     |P=0.146      P=0.507      (e)          P=0.248      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.484     |P=0.139      P=0.503      (e)          P=0.257      | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.140      P=0.500      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.115      (e)          (e)          (e)         |P=0.079      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 12      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    2/50 (4%)    7/50 (14%)  |3/50 (6%)    1/50 (2%)    5/50 (10%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/46.93      1/48.03      2/43.03      7/46.66     |3/45.20      1/45.93      5/47.68      1/46.46      | 
|POLY-3 PERCENT (g) |     10.7%        2.1%         4.7%         15.0%       |6.6%         2.2%         10.5%        2.2%         | 
|TERMINAL (d)       |     4/40 (10%)   0/42 (0%)    0/35 (0%)    3/37 (8%)   |1/35 (3%)    0/37 (0%)    0/39 (0%)    1/38 (3%)    | 
|FIRST INCIDENCE    |     612          565          519          513         |684          715          551          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.130      P=0.101N     P=0.276N     P=0.345     |P=0.350N     P=0.299N     P=0.383      P=0.281N     | 
|POLY 3             |     P=0.135      P=0.096N     P=0.253N     P=0.375     |P=0.358N     P=0.300N     P=0.386      P=0.296N     | 
|POLY 1.5           |     P=0.139      P=0.099N     P=0.243N     P=0.377     |P=0.362N     P=0.302N     P=0.374      P=0.299N     | 
|POLY 6             |     P=0.131      P=0.093N     P=0.260N     P=0.374     |P=0.351N     P=0.299N     P=0.401      P=0.291N     | 
|LOGISTIC REGRESSION|     P=0.166      P=0.111N     P=0.193N     P=0.418     |P=0.386N     P=0.300N     P=0.350      P=0.294N     | 
|COCH-ARM / FISHERS |     P=0.148      P=0.102N     P=0.218N     P=0.380     |P=0.371N     P=0.309N     P=0.357      P=0.309N     | 
|ORDER RESTRICTED   |     P=0.073      (e)          (e)          (e)         |P=0.273N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Tension Lipidosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    3/50 (6%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/46.76      3/47.50      3/44.51      1/45.34     |1/44.99      2/45.87      3/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     8.6%         6.3%         6.7%         2.2%        |2.2%         4.4%         6.5%         0.0%         | 
|TERMINAL (d)       |     3/40 (8%)    3/42 (7%)    0/35 (0%)    1/37 (3%)   |1/35 (3%)    2/37 (5%)    3/39 (8%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     666          729 (T)      412          729 (T)     |731 (T)      731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.164N     P=0.474N     P=0.551N     P=0.205N    |P=0.310N     P=0.519      P=0.344      P=0.484N     | 
|POLY 3             |     P=0.148N     P=0.492N     P=0.527N     P=0.188N    |P=0.323N     P=0.507      P=0.312      P=0.494N     | 
|POLY 1.5           |     P=0.144N     P=0.495N     P=0.521N     P=0.185N    |P=0.327N     P=0.504      P=0.310      P=0.496N     | 
|POLY 6             |     P=0.153N     P=0.485N     P=0.531N     P=0.192N    |P=0.315N     P=0.508      P=0.315      P=0.490N     | 
|LOGISTIC REGRESSION|     P=0.105N     P=0.486N     P=0.315N     P=0.187N    |P=0.310N     P=0.519      P=0.344      (e)          | 
|COCH-ARM / FISHERS |     P=0.135N     P=0.500N     P=0.500N     P=0.181N    |P=0.337N     P=0.500      P=0.309      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.155N     (e)          (e)          (e)         |P=0.186N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 13      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.73      0/47.50      2/43.52      1/46.12     |0/44.99      0/45.87      0/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         4.6%         2.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     676          ---          501          441         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.489      P=0.491N     P=0.461      P=0.755     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.492      P=0.497N     P=0.475      P=0.758     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.496      P=0.498N     P=0.481      P=0.759     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.487      P=0.494N     P=0.471      P=0.756     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.574      P=0.511N     P=0.657      P=0.660N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500      P=0.500N     P=0.500      P=0.753N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.358      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   5/50 (10%)   2/50 (4%)   |1/50 (2%)    5/50 (10%)   3/50 (6%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     7/46.73      5/47.50      5/42.28      2/45.34     |1/44.99      5/45.87      3/45.87      5/46.49      | 
|POLY-3 PERCENT (g) |     15.0%        10.5%        11.8%        4.4%        |2.2%         10.9%        6.5%         10.8%        | 
|TERMINAL (d)       |     6/40 (15%)   5/42 (12%)   5/35 (14%)   2/37 (5%)   |1/35 (3%)    5/37 (14%)   3/39 (8%)    4/38 (11%)   | 
|FIRST INCIDENCE    |     676          729 (T)      729 (T)      729 (T)     |731 (T)      731 (T)      731 (T)      724          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.092N     P=0.346N     P=0.475N     P=0.101N    |P=0.177      P=0.115      P=0.344      P=0.125      | 
|POLY 3             |     P=0.076N     P=0.368N     P=0.451N     P=0.086N    |P=0.163      P=0.106      P=0.312      P=0.109      | 
|POLY 1.5           |     P=0.072N     P=0.373N     P=0.430N     P=0.084N    |P=0.160      P=0.104      P=0.310      P=0.107      | 
|POLY 6             |     P=0.080N     P=0.360N     P=0.468N     P=0.089N    |P=0.170      P=0.106      P=0.315      P=0.113      | 
|LOGISTIC REGRESSION|     P=0.081N     P=0.346N     P=0.463N     P=0.089N    |P=0.184      P=0.115      P=0.344      P=0.125      | 
|COCH-ARM / FISHERS |     P=0.066N     P=0.380N     P=0.380N     P=0.080N    |P=0.151      P=0.102      P=0.309      P=0.102      | 
|ORDER RESTRICTED   |     P=0.071N     (e)          (e)          (e)         |P=0.094      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 14      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.53      1/47.50      3/42.59      0/45.34     |1/45.98      0/45.87      2/46.45      0/46.46      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         7.0%         0.0%        |2.2%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    1/42 (2%)    1/35 (3%)    0/37 (0%)   |0/35 (0%)    0/37 (0%)    1/39 (3%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      659          ---         |177          ---          551          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.443N     P=0.751N     P=0.266      P=0.516N    |P=0.455N     P=0.504N     P=0.513      P=0.500N     | 
|POLY 3             |     P=0.424N     P=0.756N     P=0.274      P=0.505N    |P=0.457N     P=0.500N     P=0.504      P=0.498N     | 
|POLY 1.5           |     P=0.418N     P=0.758N     P=0.282      P=0.503N    |P=0.459N     P=0.501N     P=0.500      P=0.499N     | 
|POLY 6             |     P=0.430N     P=0.753N     P=0.270      P=0.507N    |P=0.452N     P=0.500N     P=0.508      P=0.495N     | 
|LOGISTIC REGRESSION|     P=0.421N     P=0.751N     P=0.277      (e)         |P=0.533N     P=0.341N     P=0.510      (e)          | 
|COCH-ARM / FISHERS |     P=0.409N     P=0.753N     P=0.309      P=0.500N    |P=0.461N     P=0.500N     P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.220N     (e)          (e)          (e)         |P=0.323N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Bronchiole                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    3/50 (6%)    2/50 (4%)   |0/50 (0%)    4/50 (8%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.53      2/47.50      3/42.28      2/45.34     |0/44.99      4/45.87      2/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     2.2%         4.2%         7.1%         4.4%        |0.0%         8.7%         4.4%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    2/42 (5%)    3/35 (9%)    2/37 (5%)   |0/35 (0%)    4/37 (11%)   2/39 (5%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |---          731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.357      P=0.517      P=0.258      P=0.473     |P=0.310N     P=0.070      P=0.262      (e)          | 
|POLY 3             |     P=0.385      P=0.507      P=0.272      P=0.491     |P=0.318N     P=0.063      P=0.242      (e)          | 
|POLY 1.5           |     P=0.393      P=0.504      P=0.281      P=0.494     |P=0.324N     P=0.062      P=0.240      (e)          | 
|POLY 6             |     P=0.378      P=0.513      P=0.265      P=0.488     |P=0.309N     P=0.063      P=0.243      (e)          | 
|LOGISTIC REGRESSION|     P=0.357      P=0.517      P=0.258      P=0.473     |(e)          P=0.070      P=0.262      (e)          | 
|COCH-ARM / FISHERS |     P=0.404      P=0.500      P=0.309      P=0.500     |P=0.337N     P=0.059      P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.322      (e)          (e)          (e)         |P=0.181N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 15      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/37 (0%)    0/36 (0%)    1/32 (3%)    0/34 (0%)   |0/40 (0%)    2/42 (5%)    0/39 (0%)    0/38 (0%)    | 
|POLY-3 RATE (b)    |     0/34.11      0/33.60      1/28.09      0/30.80     |0/35.88      2/38.14      0/35.63      0/35.77      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         3.6%         0.0%        |0.0%         5.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/29 (0%)    0/29 (0%)    1/23 (4%)    0/25 (0%)   |0/29 (0%)    2/31 (7%)    0/30 (0%)    0/31 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          731 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.670      (e)          P=0.454      (e)         |P=0.395N     P=0.253      (e)          (e)          | 
|POLY 3             |     P=0.676      (e)          P=0.461      (e)         |P=0.408N     P=0.250      (e)          (e)          | 
|POLY 1.5           |     P=0.679      (e)          P=0.462      (e)         |P=0.411N     P=0.250      (e)          (e)          | 
|POLY 6             |     P=0.672      (e)          P=0.461      (e)         |P=0.405N     P=0.250      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.454      (e)         |(e)          P=0.253      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.681      (e)          P=0.464      (e)         |P=0.419N     P=0.259      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.347      (e)          (e)          (e)         |P=0.259N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/9 (100%)   3/3 (100%)   3/3 (100%)   3/4 (75%)   |9/11 (82%)   9/11 (82%)   11/13 (85%)  7/8 (88%)    | 
|POLY-3 RATE (b)    |     9/9.00       3/3.00       3/3.00       3/3.58      |9/11.00      9/10.02      11/12.88     7/7.83       | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       83.9%       |81.8%        89.9%        85.4%        89.4%        | 
|TERMINAL (d)       |     8/8 (100%)   2/2 (100%)   3/3 (100%)   2/2 (100%)  |6/8 (75%)    7/7 (100%)   10/11 (91%)  7/7 (100%)   | 
|FIRST INCIDENCE    |     678          661          729 (T)      656         |537          687          673          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.639N     (e)          (e)          P=0.744     |P=0.278N     P=0.530      P=0.568N     P=0.459N     | 
|POLY 3             |     P=0.238N     (e)          (e)          P=0.631N    |P=0.481      P=0.540      P=0.622      P=0.577      | 
|POLY 1.5           |     P=0.176N     (e)          (e)          P=0.458N    |P=0.482      P=0.617      P=0.630      P=0.595      | 
|POLY 6             |     P=0.470N     (e)          (e)          P=0.953N    |P=0.460      P=0.430      P=0.607      P=0.543      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.599N     P=0.685      P=0.609      P=0.612      | 
|COCH-ARM / FISHERS |     P=0.133N     (e)          (e)          P=0.308N    |P=0.472      P=0.707N     P=0.637      P=0.624      | 
|ORDER RESTRICTED   |     P=0.044N*    (e)          (e)          (e)         |P=0.517      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 16      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    3/50 (6%)    2/50 (4%)   |4/50 (8%)    3/50 (6%)    2/50 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     4/46.72      1/47.50      3/42.92      2/46.12     |4/46.08      3/47.23      2/45.99      0/45.46      | 
|POLY-3 PERCENT (g) |     8.6%         2.1%         7.0%         4.3%        |8.7%         6.4%         4.4%         0.0%         | 
|TERMINAL (d)       |     3/40 (8%)    1/42 (2%)    2/35 (6%)    1/37 (3%)   |2/35 (6%)    1/37 (3%)    1/39 (3%)    0/37 (0%)    | 
|FIRST INCIDENCE    |     678          729 (T)      520          441         |177          21           701          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.413N     P=0.166N     P=0.567N     P=0.365N    |P=0.035N*    P=0.485N     P=0.316N     P=0.060N     | 
|POLY 3             |     P=0.385N     P=0.174N     P=0.546N     P=0.343N    |P=0.038N*    P=0.486N     P=0.338N     P=0.062N     | 
|POLY 1.5           |     P=0.380N     P=0.176N     P=0.534N     P=0.341N    |P=0.039N*    P=0.491N     P=0.341N     P=0.063N     | 
|POLY 6             |     P=0.392N     P=0.170N     P=0.555N     P=0.347N    |P=0.037N*    P=0.483N     P=0.335N     P=0.060N     | 
|LOGISTIC REGRESSION|     P=0.347N     P=0.172N     P=0.505N     P=0.291N    |P=0.045N*    P=0.536N     P=0.338N     P=0.081N     | 
|COCH-ARM / FISHERS |     P=0.371N     P=0.181N     P=0.500N     P=0.339N    |P=0.038N*    P=0.500N     P=0.339N     P=0.061N     | 
|ORDER RESTRICTED   |     P=0.293N     (e)          (e)          (e)         |P=0.037N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Glands                                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     33/50 (66%)  32/50 (64%)  24/50 (48%)  26/50 (52%) |23/50 (46%)  30/50 (60%)  23/50 (46%)  20/49 (41%)  | 
|POLY-3 RATE (b)    |     33/48.30     32/49.14     24/45.48     26/47.29    |23/47.28     30/47.75     23/46.66     20/45.96     | 
|POLY-3 PERCENT (g) |     68.3%        65.1%        52.8%        55.0%       |48.7%        62.8%        49.3%        43.5%        | 
|TERMINAL (d)       |     27/40 (68%)  27/42 (64%)  18/35 (51%)  20/37 (54%) |15/35 (43%)  23/37 (62%)  19/39 (49%)  18/37 (49%)  | 
|FIRST INCIDENCE    |     598          493          412          551         |368          515          648          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.198N     P=0.390N     P=0.217N     P=0.240N    |P=0.111N     P=0.203      P=0.433N     P=0.271N     | 
|POLY 3             |     P=0.076N     P=0.452N     P=0.087N     P=0.125N    |P=0.177N     P=0.115      P=0.557      P=0.386N     | 
|POLY 1.5           |     P=0.068N     P=0.471N     P=0.077N     P=0.119N    |P=0.170N     P=0.112      P=0.563      P=0.379N     | 
|POLY 6             |     P=0.084N     P=0.431N     P=0.098N     P=0.132N    |P=0.181N     P=0.115      P=0.547      P=0.390N     | 
|LOGISTIC REGRESSION|     P=0.071N     P=0.485N     P=0.085N     P=0.129N    |P=0.147N     P=0.119      P=0.564N     P=0.351N     | 
|COCH-ARM / FISHERS |     P=0.058N     P=0.500N     P=0.053N     P=0.111N    |P=0.170N     P=0.115      P=0.579N     P=0.376N     | 
|ORDER RESTRICTED   |     P=0.108N     (e)          (e)          (e)         |P=0.180N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 17      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |8/50 (16%)   5/50 (10%)   4/50 (8%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     1/46.73      1/47.50      2/43.28      0/45.34     |8/46.13      5/45.87      4/46.49      1/45.46      | 
|POLY-3 PERCENT (g) |     2.1%         2.1%         4.6%         0.0%        |17.3%        10.9%        8.6%         2.2%         | 
|TERMINAL (d)       |     0/40 (0%)    1/42 (2%)    1/35 (3%)    0/37 (0%)   |6/35 (17%)   5/37 (14%)   3/39 (8%)    1/37 (3%)    | 
|FIRST INCIDENCE    |     676          729 (T)      26           ---         |177          731 (T)      530          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.389N     P=0.750N     P=0.470      P=0.510N    |P=0.010N*    P=0.249N     P=0.146N     P=0.016N*    | 
|POLY 3             |     P=0.380N     P=0.757N     P=0.473      P=0.506N    |P=0.012N*    P=0.279N     P=0.173N     P=0.017N*    | 
|POLY 1.5           |     P=0.375N     P=0.758N     P=0.483      P=0.504N    |P=0.012N*    P=0.282N     P=0.178N     P=0.017N*    | 
|POLY 6             |     P=0.387N     P=0.754N     P=0.466      P=0.509N    |P=0.011N*    P=0.278N     P=0.168N     P=0.016N*    | 
|LOGISTIC REGRESSION|     P=0.282N     P=0.759      P=0.731N     P=0.483N    |P=0.013N*    P=0.278N     P=0.181N     P=0.022N*    | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.753N     P=0.500      P=0.500N    |P=0.013N*    P=0.277N     P=0.178N     P=0.017N*    | 
|ORDER RESTRICTED   |     P=0.271N     (e)          (e)          (e)         |P=0.009N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |24/50 (48%)  19/50 (38%)  20/50 (40%)  13/49 (27%)  | 
|POLY-3 RATE (b)    |     0/46.53      1/47.50      3/42.28      0/45.34     |24/46.43     19/47.21     20/47.65     13/45.66     | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         7.1%         0.0%        |51.7%        40.3%        42.0%        28.5%        | 
|TERMINAL (d)       |     0/40 (0%)    1/42 (2%)    3/35 (9%)    0/37 (0%)   |20/35 (57%)  13/37 (35%)  15/39 (39%)  11/37 (30%)  | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |177          598          75           687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.602      P=0.510      P=0.098      (e)         |P=0.015N*    P=0.170N     P=0.173N     P=0.012N*    | 
|POLY 3             |     P=0.621      P=0.504      P=0.102      (e)         |P=0.020N*    P=0.181N     P=0.228N     P=0.017N*    | 
|POLY 1.5           |     P=0.627      P=0.502      P=0.107      (e)         |P=0.021N*    P=0.200N     P=0.245N     P=0.019N*    | 
|POLY 6             |     P=0.615      P=0.507      P=0.099      (e)         |P=0.017N*    P=0.159N     P=0.208N     P=0.014N*    | 
|LOGISTIC REGRESSION|     (e)          P=0.510      P=0.098      (e)         |P=0.022N*    P=0.202N     P=0.273N     P=0.019N*    | 
|COCH-ARM / FISHERS |     P=0.634      P=0.500      P=0.121      (e)         |P=0.023N*    P=0.210N     P=0.273N     P=0.022N*    | 
|ORDER RESTRICTED   |     P=0.202      (e)          (e)          (e)         |P=0.014N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 18      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   11/50 (22%)  13/50 (26%)  6/50 (12%)  |3/50 (6%)    3/50 (6%)    7/50 (14%)   1/49 (2%)    | 
|POLY-3 RATE (b)    |     9/46.53      11/48.19     13/42.87     6/46.11     |3/45.28      3/46.85      7/46.13      1/45.46      | 
|POLY-3 PERCENT (g) |     19.3%        22.8%        30.3%        13.0%       |6.6%         6.4%         15.2%        2.2%         | 
|TERMINAL (d)       |     9/40 (23%)   10/42 (24%)  11/35 (31%)  4/37 (11%)  |1/35 (3%)    1/37 (3%)    5/39 (13%)   1/37 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      493          639          551         |681          515          695          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.316N     P=0.447      P=0.139      P=0.341N    |P=0.295N     P=0.645N     P=0.197      P=0.286N     | 
|POLY 3             |     P=0.245N     P=0.435      P=0.168      P=0.293N    |P=0.318N     P=0.646N     P=0.165      P=0.304N     | 
|POLY 1.5           |     P=0.238N     P=0.421      P=0.184      P=0.292N    |P=0.320N     P=0.652N     P=0.162      P=0.306N     | 
|POLY 6             |     P=0.248N     P=0.455      P=0.160      P=0.292N    |P=0.312N     P=0.642N     P=0.167      P=0.300N     | 
|LOGISTIC REGRESSION|     P=0.255N     P=0.417      P=0.145      P=0.303N    |P=0.330N     P=0.662      P=0.165      P=0.305N     | 
|COCH-ARM / FISHERS |     P=0.225N     P=0.402      P=0.235      P=0.288N    |P=0.330N     P=0.661N     P=0.159      P=0.316N     | 
|ORDER RESTRICTED   |     P=0.148N     (e)          (e)          (e)         |P=0.151N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Turbinate                                                                                                                  | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/46.53      0/47.50      0/42.28      0/45.34     |0/44.99      0/45.87      2/45.87      0/45.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.4%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    0/37 (0%)    2/39 (5%)    0/37 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.606      (e)          P=0.262      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.605      (e)          P=0.242      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.601      (e)          P=0.240      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.613      (e)          P=0.243      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.262      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.591      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.251      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 19      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |14/49 (29%)  13/50 (26%)  13/48 (27%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |                                                        |14/44.98     13/46.62     13/45.13     9/46.62      | 
|POLY-3 PERCENT (g) |                                                        |31.1%        27.9%        28.8%        19.3%        | 
|TERMINAL (d)       |                                                        |14/35 (40%)  7/37 (19%)   10/38 (26%)  7/38 (18%)   | 
|FIRST INCIDENCE    |                                                        |731 (T)      662          530          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.102N     P=0.441N     P=0.407N     P=0.115N     | 
|POLY 3             |                                                        |P=0.121N     P=0.456N     P=0.496N     P=0.143N     | 
|POLY 1.5           |                                                        |P=0.127N     P=0.473N     P=0.516N     P=0.151N     | 
|POLY 6             |                                                        |P=0.110N     P=0.433N     P=0.467N     P=0.129N     | 
|LOGISTIC REGRESSION|                                                        |P=0.121N     P=0.471N     P=0.523N     P=0.108N     | 
|COCH-ARM / FISHERS |                                                        |P=0.132N     P=0.475N     P=0.525N     P=0.157N     | 
|ORDER RESTRICTED   |                                                        |P=0.155N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |3/50 (6%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.24      0/47.50      0/41.84      0/45.34     |3/45.09      0/45.87      1/45.09      0/46.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |6.7%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |2/35 (6%)    0/37 (0%)    1/39 (3%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |706          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.078N     P=0.115N     P=0.278N     P=0.108N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.085N     P=0.116N     P=0.305N     P=0.113N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.085N     P=0.117N     P=0.308N     P=0.115N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.084N     P=0.115N     P=0.302N     P=0.111N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.081N     P=0.116N     P=0.298N     P=0.112N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.087N     P=0.121N     P=0.316N     P=0.121N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.019N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 20      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/47 (0%)    0/48 (0%)    0/49 (0%)   |1/50 (2%)    3/49 (6%)    3/48 (6%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/46.53      0/45.01      0/40.84      0/44.34     |1/44.99      3/45.32      3/44.28      2/45.56      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         6.6%         6.8%         4.4%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/34 (0%)    0/36 (0%)   |1/35 (3%)    1/36 (3%)    3/39 (8%)    1/38 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      628          731 (T)      714          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.516      P=0.319      P=0.344      P=0.533      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.487      P=0.308      P=0.299      P=0.504      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.481      P=0.304      P=0.296      P=0.501      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.498      P=0.311      P=0.304      P=0.511      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.479      P=0.298      P=0.344      P=0.513      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.469      P=0.301      P=0.293      P=0.492      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.333      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/47 (0%)    2/48 (4%)    0/49 (0%)   |10/50 (20%)  8/49 (16%)   13/48 (27%)  11/49 (22%)  | 
|POLY-3 RATE (b)    |     1/46.53      0/45.01      2/41.57      0/44.34     |10/45.02     8/44.87      13/44.81     11/45.49     | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         4.8%         0.0%        |22.2%        17.8%        29.0%        24.2%        | 
|TERMINAL (d)       |     1/40 (3%)    0/42 (0%)    1/34 (3%)    0/36 (0%)   |9/35 (26%)   8/36 (22%)   12/39 (31%)  11/38 (29%)  | 
|FIRST INCIDENCE    |     729 (T)      ---          471          ---         |724          731 (T)      567          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.488N     P=0.490N     P=0.458      P=0.521N    |P=0.425      P=0.369N     P=0.421      P=0.586      | 
|POLY 3             |     P=0.476N     P=0.507N     P=0.461      P=0.510N    |P=0.351      P=0.399N     P=0.310      P=0.511      | 
|POLY 1.5           |     P=0.470N     P=0.509N     P=0.467      P=0.507N    |P=0.342      P=0.406N     P=0.296      P=0.501      | 
|POLY 6             |     P=0.483N     P=0.502N     P=0.457      P=0.512N    |P=0.369      P=0.397N     P=0.327      P=0.528      | 
|LOGISTIC REGRESSION|     P=0.436N     (e)          P=0.550      (e)         |P=0.390      P=0.380N     P=0.310      P=0.591      | 
|COCH-ARM / FISHERS |     P=0.462N     P=0.515N     P=0.485      P=0.505N    |P=0.322      P=0.416N     P=0.278      P=0.479      | 
|ORDER RESTRICTED   |     P=0.316N     (e)          (e)          (e)         |P=0.365      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 21      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    0/50 (0%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.73      3/47.60      0/42.28      1/45.34     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         6.3%         0.0%         2.2%        |                                                    | 
|TERMINAL (d)       |     1/40 (3%)    2/42 (5%)    0/35 (0%)    1/37 (3%)   |                                                    | 
|FIRST INCIDENCE    |     676          704          ---          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.273N     P=0.524      P=0.268N     P=0.524N    |                                                    | 
|POLY 3             |     P=0.256N     P=0.508      P=0.260N     P=0.510N    |                                                    | 
|POLY 1.5           |     P=0.251N     P=0.504      P=0.253N     P=0.506N    |                                                    | 
|POLY 6             |     P=0.261N     P=0.515      P=0.266N     P=0.515N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.256N     P=0.502      P=0.247N     P=0.506N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.242N     P=0.500      P=0.247N     P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.205N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/46.53      1/47.50      0/42.28      2/45.81     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         4.4%        |                                                    | 
|TERMINAL (d)       |     0/40 (0%)    1/42 (2%)    0/35 (0%)    1/37 (3%)   |                                                    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          593         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.129      P=0.510      (e)          P=0.227     |                                                    | 
|POLY 3             |     P=0.135      P=0.504      (e)          P=0.234     |                                                    | 
|POLY 1.5           |     P=0.136      P=0.502      (e)          P=0.235     |                                                    | 
|POLY 6             |     P=0.134      P=0.507      (e)          P=0.233     |                                                    | 
|LOGISTIC REGRESSION|     P=0.142      P=0.510      (e)          P=0.264     |                                                    | 
|COCH-ARM / FISHERS |     P=0.140      P=0.500      (e)          P=0.247     |                                                    | 
|ORDER RESTRICTED   |     P=0.073      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 22      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/49 (2%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/46.53      2/47.52      1/41.99      0/45.34     |2/44.99      2/45.87      5/46.49      2/46.46      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         2.4%         0.0%        |4.5%         4.4%         10.8%        4.3%         | 
|TERMINAL (d)       |     0/40 (0%)    1/42 (2%)    0/34 (0%)    0/37 (0%)   |2/35 (6%)    2/37 (5%)    4/39 (10%)   2/38 (5%)    | 
|FIRST INCIDENCE    |     ---          724          480          ---         |731 (T)      731 (T)      530          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.481N     P=0.253      P=0.488      (e)         |P=0.556      P=0.675N     P=0.258      P=0.665N     | 
|POLY 3             |     P=0.472N     P=0.242      P=0.480      (e)         |P=0.540      P=0.687N     P=0.230      P=0.682N     | 
|POLY 1.5           |     P=0.469N     P=0.240      P=0.484      (e)         |P=0.534      P=0.690N     P=0.225      P=0.686N     | 
|POLY 6             |     P=0.475N     P=0.245      P=0.477      (e)         |P=0.552      P=0.686N     P=0.235      P=0.676N     | 
|LOGISTIC REGRESSION|     P=0.436N     P=0.250      P=0.669      (e)         |P=0.530      P=0.675N     P=0.218      P=0.665N     | 
|COCH-ARM / FISHERS |     P=0.462N     P=0.247      P=0.495      (e)         |P=0.521      P=0.691N     P=0.218      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.317      (e)          (e)          (e)         |P=0.420      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/49 (2%)    3/49 (6%)   |5/50 (10%)   1/50 (2%)    7/49 (14%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     2/46.53      1/47.50      1/41.84      3/45.58     |5/45.24      1/46.20      7/46.27      5/46.46      | 
|POLY-3 PERCENT (g) |     4.3%         2.1%         2.4%         6.6%        |11.1%        2.2%         15.1%        10.8%        | 
|TERMINAL (d)       |     2/40 (5%)    1/42 (2%)    1/35 (3%)    1/37 (3%)   |3/35 (9%)    0/37 (0%)    3/39 (8%)    5/38 (13%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      513         |691          638          551          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.293      P=0.483N     P=0.547N     P=0.474     |P=0.384      P=0.101N     P=0.429      P=0.577N     | 
|POLY 3             |     P=0.309      P=0.493N     P=0.537N     P=0.491     |P=0.348      P=0.097N     P=0.395      P=0.613N     | 
|POLY 1.5           |     P=0.312      P=0.496N     P=0.529N     P=0.490     |P=0.346      P=0.099N     P=0.382      P=0.618N     | 
|POLY 6             |     P=0.307      P=0.487N     P=0.542N     P=0.492     |P=0.355      P=0.095N     P=0.410      P=0.607N     | 
|LOGISTIC REGRESSION|     P=0.317      P=0.483N     P=0.547N     P=0.511     |P=0.339      P=0.102N     P=0.365      P=0.598N     | 
|COCH-ARM / FISHERS |     P=0.316      P=0.500N     P=0.508N     P=0.490     |P=0.337      P=0.102N     P=0.365      P=0.630N     | 
|ORDER RESTRICTED   |     P=0.288      (e)          (e)          (e)         |P=0.240      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 23      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/49 (6%)    2/49 (4%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/47.53      3/46.69      2/42.99      1/45.68     |1/45.50      2/46.05      1/45.87      2/46.46      | 
|POLY-3 PERCENT (g) |     6.3%         6.4%         4.7%         2.2%        |2.2%         4.3%         2.2%         4.3%         | 
|TERMINAL (d)       |     0/40 (0%)    3/42 (7%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    1/37 (3%)    1/39 (3%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     612          729 (T)      480          637         |578          683          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.227N     P=0.645N     P=0.559N     P=0.329N    |P=0.467      P=0.512      P=0.751N     P=0.519      | 
|POLY 3             |     P=0.210N     P=0.654      P=0.545N     P=0.320N    |P=0.452      P=0.504      P=0.759N     P=0.507      | 
|POLY 1.5           |     P=0.204N     P=0.653      P=0.536N     P=0.314N    |P=0.451      P=0.503      P=0.759N     P=0.505      | 
|POLY 6             |     P=0.217N     P=0.655      P=0.553N     P=0.326N    |P=0.457      P=0.505      P=0.759N     P=0.511      | 
|LOGISTIC REGRESSION|     P=0.157N     P=0.631      P=0.344N     P=0.220N    |P=0.443      P=0.500      P=0.762      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.193N     P=0.651      P=0.510N     P=0.309N    |P=0.444      P=0.500      P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.277N     (e)          (e)          (e)         |P=0.452      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    3/49 (6%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/46.90      2/46.69      3/43.63      0/45.34     |0/44.99      1/46.05      0/45.87      2/46.46      | 
|POLY-3 PERCENT (g) |     2.1%         4.3%         6.9%         0.0%        |0.0%         2.2%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/40 (0%)    2/42 (5%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     622          729 (T)      480          ---         |---          683          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.364N     P=0.516      P=0.270      P=0.509N    |P=0.151      P=0.505      (e)          P=0.257      | 
|POLY 3             |     P=0.355N     P=0.498      P=0.280      P=0.507N    |P=0.144      P=0.505      (e)          P=0.244      | 
|POLY 1.5           |     P=0.347N     P=0.496      P=0.283      P=0.504N    |P=0.143      P=0.503      (e)          P=0.242      | 
|POLY 6             |     P=0.363N     P=0.503      P=0.279      P=0.510N    |P=0.147      P=0.506      (e)          P=0.248      | 
|LOGISTIC REGRESSION|     P=0.280N     P=0.480      P=0.485      P=0.443N    |P=0.143      P=0.499      (e)          P=0.257      | 
|COCH-ARM / FISHERS |     P=0.336N     P=0.492      P=0.301      P=0.500N    |P=0.140      P=0.500      (e)          P=0.247      | 
|ORDER RESTRICTED   |     P=0.184N     (e)          (e)          (e)         |P=0.079      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 24      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/49 (2%)    0/49 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.73      1/47.18      0/41.84      2/46.69     |0/44.99      0/45.87      0/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     4.3%         2.1%         0.0%         4.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     676          582          ---          441         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570      P=0.492N     P=0.268N     P=0.679     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.582      P=0.497N     P=0.263N     P=0.693     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.586      P=0.501N     P=0.257N     P=0.694     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.578      P=0.490N     P=0.267N     P=0.693     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.604N     P=0.532N     P=0.250N     P=0.573N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.592      P=0.508N     P=0.253N     P=0.691N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.425      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Artery                                                                                                     | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.53      0/46.69      0/41.84      0/45.34     |2/45.86      0/45.87      0/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |1/35 (3%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |368          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.112N     P=0.234N     P=0.228N     P=0.231N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.237N     P=0.237N     P=0.234N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.238N     P=0.238N     P=0.236N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.114N     P=0.237N     P=0.236N     P=0.231N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.121N     P=0.216N     P=0.224N     P=0.291N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.115N     P=0.247N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.029N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 25      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular: Artery                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)   |2/49 (4%)    0/50 (0%)    0/48 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/46.24      0/46.69      0/41.84      0/45.12     |2/44.54      0/45.87      0/44.28      0/46.37      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |1/35 (3%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |681          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.110N     P=0.234N     P=0.228N     P=0.226N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.116N     P=0.231N     P=0.238N     P=0.228N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.116N     P=0.231N     P=0.240N     P=0.231N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.116N     P=0.231N     P=0.237N     P=0.226N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.115N     P=0.232N     P=0.241N     P=0.235N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.116N     P=0.242N     P=0.253N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.026N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    3/50 (6%)    1/50 (2%)   |                                                    | 
|POLY-3 RATE (b)    |     2/46.63      2/47.50      3/42.28      1/45.54     |                                                    | 
|POLY-3 PERCENT (g) |     4.3%         4.2%         7.1%         2.2%        |                                                    | 
|TERMINAL (d)       |     1/40 (3%)    2/42 (5%)    3/35 (9%)    0/37 (0%)   |                                                    | 
|FIRST INCIDENCE    |     704          729 (T)      729 (T)      678         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.446N     P=0.674N     P=0.440      P=0.515N    |                                                    | 
|POLY 3             |     P=0.421N     P=0.687N     P=0.456      P=0.508N    |                                                    | 
|POLY 1.5           |     P=0.415N     P=0.690N     P=0.468      P=0.505N    |                                                    | 
|POLY 6             |     P=0.427N     P=0.682N     P=0.446      P=0.511N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.427N     P=0.682N     P=0.446      P=0.499N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.404N     P=0.691N     P=0.500      P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.391N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 26      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/46.53      0/47.50      1/42.28      2/45.34     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         2.4%         4.4%        |                                                    | 
|TERMINAL (d)       |     1/40 (3%)    0/42 (0%)    1/35 (3%)    2/37 (5%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.221      P=0.490N     P=0.732      P=0.473     |                                                    | 
|POLY 3             |     P=0.237      P=0.496N     P=0.739      P=0.491     |                                                    | 
|POLY 1.5           |     P=0.242      P=0.498N     P=0.745      P=0.494     |                                                    | 
|POLY 6             |     P=0.233      P=0.493N     P=0.734      P=0.488     |                                                    | 
|LOGISTIC REGRESSION|     P=0.221      (e)          P=0.732      P=0.473     |                                                    | 
|COCH-ARM / FISHERS |     P=0.247      P=0.500N     P=0.753N     P=0.500     |                                                    | 
|ORDER RESTRICTED   |     P=0.215      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/49 (8%)    6/50 (12%)   8/50 (16%)  |7/50 (14%)   5/50 (10%)   11/49 (22%)  8/48 (17%)   | 
|POLY-3 RATE (b)    |     4/46.53      4/46.71      6/42.72      8/45.36     |7/45.48      5/46.26      11/45.63     8/44.99      | 
|POLY-3 PERCENT (g) |     8.6%         8.6%         14.1%        17.6%       |15.4%        10.8%        24.1%        17.8%        | 
|TERMINAL (d)       |     4/40 (10%)   3/42 (7%)    5/35 (14%)   7/37 (19%)  |6/35 (17%)   4/37 (11%)   9/38 (24%)   6/37 (16%)   | 
|FIRST INCIDENCE    |     729 (T)      724          602          725         |586          620          567          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.067      P=0.614N     P=0.288      P=0.144     |P=0.346      P=0.343N     P=0.271      P=0.545      | 
|POLY 3             |     P=0.085      P=0.641N     P=0.317      P=0.164     |P=0.296      P=0.367N     P=0.217      P=0.491      | 
|POLY 1.5           |     P=0.090      P=0.639      P=0.331      P=0.169     |P=0.289      P=0.372N     P=0.211      P=0.483      | 
|POLY 6             |     P=0.079      P=0.631N     P=0.308      P=0.159     |P=0.311      P=0.364N     P=0.223      P=0.506      | 
|LOGISTIC REGRESSION|     P=0.079      P=0.610N     P=0.305      P=0.154     |P=0.286      P=0.373N     P=0.209      P=0.483      | 
|COCH-ARM / FISHERS |     P=0.100      P=0.631      P=0.370      P=0.178     |P=0.275      P=0.380N     P=0.204      P=0.465      | 
|ORDER RESTRICTED   |     P=0.140      (e)          (e)          (e)         |P=0.254      (e)          (e)          (e)          | 
|=================================================================================================================================| 
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 27      
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                  METHYL ISOBUTYL KETONE
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    2/50 (4%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.99      2/45.87      1/45.09      2/46.46      | 
|POLY-3 PERCENT (g) |                                                        |2.2%         4.4%         2.2%         4.3%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    2/37 (5%)    1/39 (3%)    2/38 (5%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      731 (T)      731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.472      P=0.519      P=0.738N     P=0.529      | 
|POLY 3             |                                                        |P=0.456      P=0.507      P=0.760N     P=0.511      | 
|POLY 1.5           |                                                        |P=0.452      P=0.504      P=0.759      P=0.508      | 
|POLY 6             |                                                        |P=0.463      P=0.508      P=0.758N     P=0.517      | 
|LOGISTIC REGRESSION|                                                        |P=0.472      P=0.519      P=0.738N     P=0.529      | 
|COCH-ARM / FISHERS |                                                        |P=0.444      P=0.500      P=0.747      P=0.500      | 
|ORDER RESTRICTED   |                                                        |P=0.457      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |49/50 (98%)  48/50 (96%)  46/49 (94%)  49/50 (98%)  | 
|POLY-3 RATE (b)    |                                                        |49/49.01     48/49.00     46/47.68     49/50.00     | 
|POLY-3 PERCENT (g) |                                                        |100.0%       98.0%        96.5%        98.0%        | 
|TERMINAL (d)       |                                                        |35/35 (100%) 36/37 (97%)  39/39 (100%) 37/38 (97%)  | 
|FIRST INCIDENCE    |                                                        |368          515          530          329          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.260N     P=0.331N     P=0.088N     P=0.298N     | 
|POLY 3             |                                                        |P=0.381N     P=0.506N     P=0.279N     P=0.510N     | 
|POLY 1.5           |                                                        |P=0.404N     P=0.545N     P=0.275N     P=0.551N     | 
|POLY 6             |                                                        |P=0.379N     P=0.500N     P=0.332N     P=0.504N     | 
|LOGISTIC REGRESSION|                                                        |P=0.513N     P=0.465N     P=0.200N     P=0.673N     | 
|COCH-ARM / FISHERS |                                                        |P=0.578      P=0.500N     P=0.301N     P=0.753N     | 
|ORDER RESTRICTED   |                                                        |P=0.239N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).