TDMS Study 97006-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest METHYL ISOBUTYL KETONE DATE: 04/29/04
EXPERIMENT: 97006 TEST: 02 TIME: 07:53:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-05452 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C97006
PATHOLOGIST: GRUMBEIN, SONDRA CAS: 108-10-1
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest METHYL ISOBUTYL KETONE DATE: 04/29/04
EXPERIMENT: 97006 TEST: 02 TIME: 07:53:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-05452 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C97006
PATHOLOGIST: GRUMBEIN, SONDRA CAS: 108-10-1
METHYL ISOBUTYL KETONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 482 598 612 614 618 622 666 676 678 704 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 450 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 493 565 582 661 670 680 704 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 900 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 26 412 471 480 501 519 520 520 554 602 |
| 639 659 698 701 717 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
METHYL ISOBUTYL KETONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1800 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 441 513 551 593 601 607 617 637 656 678 |
| 710 717 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
METHYL ISOBUTYL KETONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 96.0 88.0 80.0 |
| | |
| | |
|450 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 94.0 92.0 84.0 |
| | |
| | |
|900 PPM | 98.0 98.0 98.0 98.0 96.0 92.0 84.0 80.0 76.0 70.0 |
| | |
| | |
|1800 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 82.0 74.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 450 PPM 900 PPM 1800 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 84.0% 70.0% 74.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.322 P=0.759N P=0.286 P=0.609 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 627.0 634.9 534.6 618.9 |
|NATURAL DEATHS (C) | (19.7) (28.2) (43.7) (23.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 708.6 713.9 670.7 700.4 |
|(STANDARD ERROR) | ( 6.9) ( 6.5) (18.1) ( 9.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
METHYL ISOBUTYL KETONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 177 368 537 578 586 632 653 681 684 691 |
| 697 706 715 715 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 450 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 1 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 515 598 620 628 638 662 683 687 702 710 |
| 715 715 |
| CENSORED DEATHS |
| 21 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 900 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 75 530 551 567 648 648 673 684 695 696 |
| 701 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
METHYL ISOBUTYL KETONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1800 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 329 435 535 617 643 687 705 714 715 719 |
| 722 724 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
METHYL ISOBUTYL KETONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.0 98.0 98.0 96.0 96.0 94.0 90.0 86.0 70.0 |
| | |
| | |
|450 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 95.9 87.8 75.5 |
| | |
| | |
|900 PPM | 98.0 98.0 98.0 98.0 98.0 98.0 96.0 92.0 88.0 78.0 |
| | |
| | |
|1800 PPM | 100.0 100.0 100.0 98.0 98.0 96.0 94.0 94.0 90.0 76.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 450 PPM 900 PPM 1800 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 75.5% 78.0% 76.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.567N P=0.659N P=0.527N P=0.590N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 609.6 656.1 588.0 628.8 |
|NATURAL DEATHS (C) | (39.3) (17.3) (54.6) (37.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 694.6 698.8 699.5 706.5 |
|(STANDARD ERROR) | (14.0) (15.1) (14.3) (10.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
METHYL ISOBUTYL KETONE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
450 PPM = 2
900 PPM = 3
1800 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 4 1 2
|
| 3 3 4 1 2 4 2 1
|
96 + 3 3 4 4 2 2 1 1
|
| 33 4 2 4 2
|
P 92 + 3 3 44 11 22
E |
R | 3 3 44 2 2
C |
E 88 + 4 1 1 2 2
N |
T | 4 4 11 2 2
|
S 84 + 3 3 4 4 2 2
U |
R | 3 3 4 1 1
V |
I 80 + 3 3 4 14 1
V |
A | 3 3 44
L |
76 + 3 3 44
|
| 33 4 4
|
72 + 3 3
|
| 3 3
|
68 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
METHYL ISOBUTYL KETONE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
450 PPM = 2
900 PPM = 3
1800 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 4 2
|
| 3 1 4 1 4 2 3 2
| 1 4 31 3 2 2
P 95 +
E | 1 3 3 1 22
R | 3 11 4 43
C | 2 2
E 90 + 1 12 2 4
N |
T | 1 31 2 324 4
| 1 312 44
S 85 +
U | 323244
R | 11
V | 22
I 80 + 113224
V |
A | 11 3
L | 1 14 4
75 + 2 2
|
| 11
|
70 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 12 obs hidden.