TDMS Study 97006-02 Pathology Tables
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 07:55:48
FINAL#1 MICE
Facility: Battelle Northwest
Chemical CAS #: 108-10-1
Lock Date: 01/24/03
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 07:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 10 9 6 9
Natural Death 5 3 5 3
Accidently Killed 1
Survivors
Terminal Sacrifice 35 37 39 38
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (48) (49) (49)
Artery, Inflammation, Chronic Active 1 [2.0]
Intestine Large, Rectum (47) (48) (48) (49)
Artery, Inflammation, Chronic Active 1 [3.0]
Intestine Large, Cecum (46) (48) (47) (49)
Artery, Inflammation, Chronic Active 1 [2.0] 1 [4.0]
Intestine Small, Duodenum (47) (48) (47) (48)
Ulcer 1 [4.0]
Peyer's Patch, Hyperplasia 1 [2.0]
Liver (50) (50) (50) (50)
Angiectasis 1 [2.0]
Basophilic Focus 3 2 1 3
Clear Cell Focus 3 4 5 2
Cyst 1 [4.0]
Eosinophilic Focus 4 11 10 14
Fatty Change 1 [2.0]
Hematopoietic Cell Proliferation 2 [2.0]
Infarct 1
Infiltration Cellular, Mast Cell 1 [2.0]
Inflammation, Chronic 1 [1.0] 2 [1.5]
Mixed Cell Focus 1 1 1 1
Necrosis 3 [2.7] 1 [2.0] 5 [2.6] 1 [1.0]
Tension Lipidosis 1 [1.0] 2 [1.5] 3 [1.7]
Thrombosis 1 [2.0]
Bile Duct, Hyperplasia 1 [2.0]
Mesentery (11) (11) (13) (8)
Artery, Inflammation, Chronic Active 1 [4.0]
Fat, Hemorrhage 1 [2.0]
Fat, Necrosis 9 [2.0] 9 [2.0] 11 [2.1] 7 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 07:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (50) (50) (49) (50)
Atrophy 3 [2.7] 1 [4.0]
Basophilic Focus 1 [2.0]
Inflammation, Chronic Active 1 [2.0] 1 [2.0]
Necrosis, Fatty 1 [3.0]
Artery, Inflammation, Chronic Active 1 [3.0]
Duct, Cyst 1 [3.0] 1 [4.0]
Salivary Glands (50) (50) (50) (50)
Atrophy 1 [2.0]
Artery, Inflammation, Chronic Active 1 [3.0]
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia, Squamous 1 [1.0] 2 [1.0] 1 [1.0] 2 [2.0]
Inflammation 1 [1.0] 2 [1.5]
Artery, Inflammation, Chronic Active 2 [2.5]
Stomach, Glandular (49) (50) (48) (49)
Metaplasia, Hepatocyte 1 [4.0]
Necrosis 1 [1.0]
Artery, Inflammation, Chronic Active 2 [3.0]
Tooth (1) (1)
Malformation 1 [4.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 3 [1.7] 6 [1.3] 5 [1.0] 3 [1.0]
Inflammation, Suppurative 1 [3.0]
Artery, Inflammation, Chronic Active 1 [3.0] 2 [2.5]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hematopoietic Cell Proliferation 1 [3.0]
Hyperplasia 4 [2.0] 3 [2.0] 1 [2.0] 2 [1.5]
Hypertrophy 3 [2.3] 3 [2.7] 3 [1.0]
Infiltration Cellular, Mononuclear Cell 1 [3.0]
Necrosis 1 [2.0]
Adrenal Medulla (50) (50) (49) (49)
Hyperplasia 2 [3.0] 2 [3.0] 1 [2.0]
Islets, Pancreatic (50) (50) (49) (50)
Hyperplasia 2 [2.0] 1 [2.0]
Pituitary Gland (50) (49) (48) (49)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 07:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Angiectasis 1 [1.0] 3 [2.3] 3 [2.3] 2 [1.5]
Pars Distalis, Hyperplasia 10 [2.4] 8 [2.6] 13 [2.5] 11 [2.6]
Pars Intermedia, Hyperplasia 1 [2.0]
Thyroid Gland (50) (50) (49) (48)
Cyst 1 [3.0]
Follicular Cell, Hyperplasia 7 [2.1] 5 [1.4] 11 [1.5] 8 [1.6]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2) (1)
Inflammation, Suppurative 1 [3.0]
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (49) (50) (48) (50)
Angiectasis 1 [2.0]
Cyst 14 [2.4] 13 [2.2] 13 [2.6] 9 [2.2]
Inflammation, Suppurative 1 [1.0]
Thrombosis 1 [3.0]
Artery, Inflammation, Chronic Active 1 [3.0] 1 [3.0]
Uterus (50) (50) (49) (50)
Amyloid Deposition 1 [2.0]
Angiectasis 1 [4.0] 2 [3.0] 1 [4.0] 2 [3.0]
Hyperplasia, Cystic 1 [3.0]
Infiltration Cellular, Mixed Cell 1 [2.0]
Inflammation, Suppurative 1 [2.0] 1 [3.0] 1 [4.0]
Metaplasia, Squamous 1 [2.0]
Necrosis 1 [3.0]
Thrombosis 1 [2.0]
Endometrium, Hyperplasia, Cystic 49 [3.2] 48 [3.3] 46 [3.1] 49 [3.4]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50)
Infiltration Cellular, Mast Cell 1 [2.0]
Lymph Node (7) (3) (9) (5)
Iliac, Ectasia 1 [2.0]
Iliac, Infiltration Cellular, Plasma Cell 1 [3.0]
Lumbar, Angiectasis 1 [3.0]
Lumbar, Ectasia 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 07:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lumbar, Infiltration Cellular, Plasma Cell 1 [4.0]
Renal, Angiectasis 1 [3.0] 1 [3.0]
Renal, Ectasia 1 [3.0]
Renal, Infiltration Cellular, Plasma Cell 1 [3.0]
Renal, Artery, Inflammation, Chronic Active 1 [3.0]
Lymph Node, Mandibular (40) (42) (39) (38)
Hyperplasia, Lymphoid 2 [2.5]
Infiltration Cellular, Plasma Cell 1 [3.0]
Lymph Node, Mesenteric (50) (49) (49) (47)
Angiectasis 1 [2.0]
Hyperplasia, Lymphoid 1 [3.0]
Lymph Node, Mediastinal (46) (40) (38) (41)
Hyperplasia, Lymphoid 1 [3.0]
Infiltration Cellular, Mast Cell 1 [2.0]
Spleen (50) (50) (49) (50)
Hematopoietic Cell Proliferation 5 [2.4] 1 [2.0] 7 [2.9] 5 [3.0]
Infiltration Cellular, Mast Cell 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (49) (50) (49)
Hyperplasia 1 [3.0]
Skin (50) (50) (50) (50)
Foreign Body 1 [3.0]
Hemorrhage 1 [4.0]
Inflammation, Chronic Active 2 [1.5] 2 [1.5] 5 [2.0] 2 [2.5]
Inflammation, Suppurative 1 [4.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fracture 1
Hyperostosis 1 [2.0]
Infiltration Cellular, Mast Cell 1 [2.0]
Skeletal Muscle (1) (2) (3) (2)
Inflammation, Suppurative 1 [3.0]
Artery, Inflammation, Chronic Active 1 [3.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 07:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Brain (50) (50) (50) (50)
Meninges, Infiltration Cellular, Mononuclear
Cell 1 [2.0] 2 [1.5] 2 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (49) (50)
Artery, Inflammation, Chronic Active 1 [3.0] 1 [3.0]
Respiratory Epithelium, Degeneration, Hyaline 1 [3.0]
Lung (50) (50) (50) (50)
Infiltration Cellular, Mononuclear Cell 1 [4.0]
Alveolar Epithelium, Hyperplasia 1 [2.0] 5 [2.2] 3 [1.7] 5 [1.0]
Alveolus, Infiltration Cellular, Histiocyte 1 [1.0] 2 [2.0]
Artery, Mineralization 1 [3.0]
Bronchiole, Hyperplasia 4 [1.0] 2 [2.0]
Nose (50) (50) (50) (49)
Infiltration Cellular, Mast Cell 1 [4.0]
Inflammation, Suppurative 4 [1.3] 3 [1.7] 2 [2.0]
Artery, Inflammation, Chronic Active 1 [2.0]
Glands, Hyperplasia 23 [1.0] 30 [1.0] 23 [1.0] 20 [1.0]
Olfactory Epithelium, Atrophy 1 [1.0] 1 [1.0]
Olfactory Epithelium, Degeneration, Hyaline 8 [1.5] 5 [1.0] 4 [1.5] 1 [1.0]
Respiratory Epithelium, Degeneration, Hyaline 24 [1.8] 19 [1.9] 20 [1.8] 13 [1.3]
Respiratory Epithelium, Metaplasia 3 [1.0] 3 [1.0] 6 [1.0] 1 [1.0]
Respiratory Epithelium, Metaplasia, Squamous 1 [1.0]
Turbinate, Necrosis 2 [1.5]
Trachea (50) (50) (49) (50)
Degeneration, Hyaline 1 [3.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (48) (49) (50)
Cataract 1 [3.0]
Degeneration 1 [4.0]
Cornea, Inflammation, Chronic Active 1 [1.0] 1 [2.0] 3 [2.3] 2 [3.0]
Cornea, Mineralization 1 [1.0]
Retina, Atrophy 1 [3.0]
Harderian Gland (49) (49) (49) (50)
Hyperplasia 1 [2.0] 1 [1.0] 2 [3.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 07:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Amyloid Deposition 1 [4.0]
Cyst 1 [3.0]
Metaplasia, Osseous 2 [1.0] 2 [1.0] 3 [1.0] 2 [1.0]
Nephropathy 22 [1.1] 28 [1.3] 26 [1.2] 27 [1.4]
Artery, Inflammation, Chronic Active 1 [3.0]
Papilla, Necrosis 1 [2.0] 1 [2.0]
Pelvis, Dilatation 1 [2.0]
Renal Tubule, Hyperplasia 1 [2.0]
Urinary Bladder (50) (50) (49) (50)
Artery, Inflammation, Chronic Active 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 07:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 9 6 12 9
Natural Death 1 2 3 4
Survivors
Terminal Sacrifice 40 42 34 37
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (43) (44) (39) (45)
Infiltration Cellular, Polymorphonuclear 1 [2.0]
Intestine Large, Rectum (50) (48) (49) (49)
Hemorrhage 1 [2.0]
Inflammation, Acute 1 [2.0]
Intestine Large, Cecum (49) (48) (47) (47)
Hemorrhage 1 [3.0]
Intestine Small, Duodenum (49) (48) (45) (47)
Ulcer 1 [3.0]
Intestine Small, Jejunum (49) (48) (47) (47)
Cyst 1 [2.0]
Peyer's Patch, Hyperplasia 1 [3.0] 1 [3.0] 2 [2.5]
Intestine Small, Ileum (49) (48) (48) (47)
Inflammation, Acute 1 [3.0]
Liver (50) (50) (50) (50)
Angiectasis 1 [2.0] 1 [2.0]
Basophilic Focus 8 5 4 8
Clear Cell Focus 22 13 13 20
Eosinophilic Focus 3 4 5 8
Hepatodiaphragmatic Nodule 1
Infarct 1 [4.0]
Inflammation, Chronic 1 [1.0]
Inflammation, Granulomatous 1 [2.0] 1 [2.0]
Mixed Cell Focus 1 1 1
Necrosis 5 [1.4] 1 [1.0] 2 [3.5] 7 [2.0]
Tension Lipidosis 4 [1.5] 3 [2.0] 3 [1.3] 1 [2.0]
Thrombosis 1 [3.0]
Bile Duct, Cyst 1
Bile Duct, Hyperplasia 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 07:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Erythrophagocytosis 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 1 [2.0] 2 [1.5] 1 [3.0]
Mesentery (9) (3) (3) (4)
Fat, Necrosis 9 [2.1] 3 [2.0] 3 [2.0] 3 [2.0]
Salivary Glands (50) (50) (48) (50)
Inflammation, Acute 1 [3.0]
Stomach, Forestomach (50) (49) (49) (50)
Hyperplasia, Squamous 3 [2.7] 3 [2.7] 2 [1.5] 1 [2.0]
Inflammation 1 [1.0] 2 [2.0] 3 [1.3]
Ulcer 2 [2.0] 1 [3.0] 2 [2.0]
Stomach, Glandular (49) (49) (49) (49)
Hyperplasia 1 [2.0]
Necrosis 1 [2.0] 1 [2.0]
Tooth (1)
Malformation 1 [4.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 10 [1.2] 8 [1.0] 2 [2.0] 10 [1.1]
Inflammation, Suppurative 1 [3.0]
Thrombosis 2 [4.0] 3 [3.0] 1 [3.0]
Artery, Inflammation, Chronic Active 2 [2.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Hyperplasia 13 [2.0] 18 [1.9] 13 [2.1] 9 [2.1]
Hypertrophy 26 [2.0] 30 [1.9] 26 [1.8] 14 [1.9]
Adrenal Medulla (50) (50) (49) (50)
Hyperplasia 1 [2.0] 1 [3.0] 3 [1.7]
Islets, Pancreatic (49) (50) (49) (50)
Hyperplasia 1 [2.0] 2 [2.0] 1 [2.0]
Pituitary Gland (50) (47) (48) (49)
Pars Distalis, Hyperplasia 1 [4.0] 2 [2.0]
Thyroid Gland (50) (49) (50) (50)
Follicular Cell, Hyperplasia 4 [1.5] 4 [2.0] 6 [1.5] 8 [1.8]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 07:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 2 [3.0] 2 [1.5] 1 [3.0]
Infiltration Cellular, Polymorphonuclear 1 [2.0]
Inflammation, Granulomatous 1 [3.0]
Penis (1) (1) (1)
Inflammation, Acute 1 [3.0] 1 [4.0]
Preputial Gland (50) (50) (50) (50)
Ectasia 2 [2.0] 3 [3.0] 1 [3.0]
Inflammation, Chronic Active 1 [3.0] 2 [2.5]
Prostate (50) (49) (49) (50)
Inflammation, Suppurative 1 [3.0] 1 [4.0]
Seminal Vesicle (50) (50) (49) (50)
Dilatation 1 [3.0]
Inflammation, Chronic Active 1 [1.0] 1 [4.0] 1 [2.0]
Testes (50) (50) (50) (50)
Atrophy 2 [2.5] 2 [2.0] 3 [1.3] 1 [2.0]
Thrombosis 1 [2.0]
Interstitial Cell, Hyperplasia 1 [2.0] 1 [1.0] 2 [2.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Bronchial (39) (35) (37) (39)
Hyperplasia, Lymphoid 1 [3.0]
Lymph Node, Mandibular (37) (36) (32) (34)
Hyperplasia, Lymphoid 1 [3.0]
Lymph Node, Mesenteric (49) (48) (48) (48)
Infiltration Cellular, Histiocyte 1 [2.0]
Lymph Node, Mediastinal (42) (38) (36) (38)
Hyperplasia, Lymphoid 1 [3.0]
Spleen (50) (50) (49) (49)
Hematopoietic Cell Proliferation 2 [2.0] 1 [3.0] 1 [3.0] 3 [2.7]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (49) (50)
Inflammation, Acute 1 [4.0]
Inflammation, Chronic Active 2 [4.0] 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 07:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Atrophy 1 [3.0]
Hyperostosis 1 [2.0]
Joint, Cartilage, Hyperplasia 1 [3.0]
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 [3.0]
Hydrocephalus 1 [3.0]
Necrosis 2 [1.5]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion, Chronic 1 [4.0]
Hemorrhage 1 [2.0]
Hyperplasia 1 [2.0]
Inflammation, Chronic Active 1 [3.0]
Pigmentation 1 [3.0]
Thrombosis 1 [4.0]
Alveolar Epithelium, Hyperplasia 7 [2.3] 5 [2.2] 5 [2.2] 2 [1.5]
Alveolus, Infiltration Cellular, Histiocyte 1 [3.0] 1 [3.0] 3 [3.3]
Bronchiole, Hyperplasia 1 [3.0] 2 [2.5] 3 [1.0] 2 [1.0]
Nose (50) (50) (50) (50)
Hyperplasia 1 [1.0]
Inflammation, Suppurative 4 [1.0] 1 [1.0] 3 [2.0] 2 [2.5]
Glands, Hyperplasia 33 [1.0] 32 [1.0] 24 [1.0] 26 [1.0]
Olfactory Epithelium, Atrophy 1 [1.0]
Olfactory Epithelium, Degeneration, Hyaline 1 [1.0] 1 [1.0] 2 [2.0]
Olfactory Epithelium, Necrosis 1 [2.0]
Respiratory Epithelium, Degeneration, Hyaline 1 [1.0] 3 [1.3]
Respiratory Epithelium, Hyperplasia 1 [2.0]
Respiratory Epithelium, Metaplasia 9 [1.0] 11 [1.0] 13 [1.1] 6 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (48) (49) (49)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 11
NTP Experiment-Test: 97006-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/29/04
Route: RESPIRATORY EXPOSURE WHOLE BODY METHYL ISOBUTYL KETONE Time: 07:55:48
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 450 PPM 900 PPM 1800 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Cataract 1 [2.0]
Degeneration 1 [2.0] 1 [3.0]
Cornea, Inflammation, Acute 1 [2.0]
Cornea, Inflammation, Chronic Active 2 [3.0]
Cornea, Mineralization 1 [1.0]
Retina, Atrophy 1 [3.0]
Harderian Gland (50) (49) (50) (50)
Hyperplasia 3 [2.3] 4 [2.5] 1 [3.0] 2 [2.0]
Hypertrophy 1 [2.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Cyst 1 [3.0]
Inflammation, Suppurative 1 [3.0] 1 [1.0] 1 [2.0] 3 [2.7]
Metaplasia, Osseous 2 [1.0] 2 [1.0] 3 [1.0] 1 [1.0]
Nephropathy 41 [1.4] 45 [1.4] 40 [1.5] 43 [1.3]
Renal Tubule, Hyperplasia 2 [1.0] 2 [1.5] 1 [2.0]
Urinary Bladder (50) (49) (49) (50)
Hemorrhage 1 [3.0]
Inflammation, Chronic Active 1 [2.0]
Inflammation, Suppurative 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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