TDMS Study 99033-01 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BIORELIANCE TRANSGENIC MODEL EVALUATION II (ASPARTAME) DATE: 03/05/03
EXPERIMENT: 99033 TEST: 01 TIME: 11:16:14
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: 26-39 WEEKS ROUTE: DOSED FEED NTP: C99033
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FINAL#3 TG.AC MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL
INCLUDE 002 3125 PPM
INCLUDE 003 6250 PPM
INCLUDE 004 12500 PPM
INCLUDE 005 25000 PPM
INCLUDE 006 50000 PPM
INCLUDE 008 VEHICLE CONTROL
INCLUDE 009 3125 PPM
INCLUDE 010 6250 PPM
INCLUDE 011 12500 PPM
INCLUDE 012 25000 PPM
INCLUDE 013 50000 PPM
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BIORELIANCE TRANSGENIC MODEL EVALUATION II (ASPARTAME) DATE: 03/05/03
EXPERIMENT: 99033 TEST: 01 TIME: 11:22:56
SPECIES: MICE, TG.AC HEMI
TEST TYPE: 26 ROUTE: DOSED FEED NTP: C99033
CONT: N01-ES-65406 CAS: 22839-47-0
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==========================================================================================================================
WEEK VEHICLE CONTROL 3125 PPM 6250 PPM 12500 PPM 25000 PPM
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
B 19.1 15 19.2 100.5 15 19.1 100.0 15 17.8 93.2 15 19.1 100.0 15
1 19.1 15 19.2 100.5 15 19.1 100.0 15 17.8 93.2 15 19.1 100.0 15
2 21.5 15 21.3 99.1 15 20.1 93.5 15 20.3 94.4 15 21.7 100.9 15
3 21.9 15 22.0 100.5 15 21.8 99.5 15 21.2 96.8 15 22.1 100.9 15
4 22.6 15 23.2 102.7 15 22.7 100.4 15 22.3 98.7 15 23.3 103.1 15
5 23.8 15 23.7 99.6 15 23.6 99.2 15 23.1 97.1 15 23.9 100.4 15
6 24.6 15 23.2 94.3 15 24.6 100.0 15 23.5 95.5 15 25.0 101.6 15
7 25.2 15 24.8 98.4 15 25.7 102.0 15 23.9 94.8 15 25.4 100.8 15
8 26.0 15 25.0 96.2 15 25.8 99.2 15 24.8 95.4 15 25.9 99.6 15
9 26.3 15 25.9 98.5 15 26.8 101.9 15 25.6 97.3 15 26.1 99.2 15
10 27.4 15 26.4 96.4 15 26.7 97.4 15 26.1 95.3 15 26.4 96.4 15
11 28.2 15 26.7 94.7 15 27.5 97.5 15 26.8 95.0 15 27.5 97.5 15
12 28.5 14 26.2 91.9 15 28.0 98.2 14 26.6 93.3 15 26.7 93.7 15
13 28.8 14 27.4 95.1 15 28.3 98.3 14 27.0 93.8 15 27.9 96.9 15
14 29.0 14 27.1 93.4 15 27.8 95.9 14 27.2 93.8 15 28.1 96.9 15
15 29.5 14 28.5 96.6 15 29.2 99.0 14 28.0 94.9 15 28.5 96.6 14
16 29.5 14 27.8 94.2 15 28.8 97.6 14 27.9 94.6 15 28.4 96.3 14
17 29.2 14 27.9 95.5 15 29.1 99.7 14 28.3 96.9 15 29.0 99.3 14
18 29.5 14 28.6 96.9 15 29.2 99.0 14 28.3 95.9 15 28.8 97.6 14
19 29.1 14 29.4 101.0 15 29.7 102.1 14 28.2 96.9 15 29.3 100.7 14
20 29.7 14 29.0 97.6 15 29.9 100.7 13 28.6 96.3 15 29.9 100.7 14
21 30.2 14 29.6 98.0 15 30.3 100.3 12 29.0 96.0 15 29.6 98.0 13
22 30.4 14 29.1 95.7 15 29.7 97.7 12 29.0 95.4 15 29.4 96.7 13
23 30.8 14 29.1 94.5 15 29.9 97.1 11 29.2 94.8 15 29.7 96.4 13
24 30.7 14 28.8 93.8 15 30.1 98.0 11 29.9 97.4 15 30.0 97.7 13
25 31.1 14 29.1 93.6 15 30.5 98.1 11 30.0 96.5 15 29.6 95.2 13
26 30.8 14 29.4 95.5 15 30.7 99.7 11 30.0 97.4 15 30.3 98.4 13
27 31.3 13 29.4 93.9 15 30.7 98.1 11 29.7 94.9 15 30.5 97.4 13
28 31.5 13 29.3 93.0 15 30.5 96.8 11 29.7 94.3 15 30.7 97.5 13
29 31.4 12 28.8 91.7 15 30.0 95.5 10 30.1 95.9 15 30.9 98.4 13
30 31.8 12 30.2 95.0 14 30.0 94.3 10 30.7 96.5 14 31.1 97.8 13
31 31.5 12 30.4 96.5 14 30.6 97.1 9 30.5 96.8 13 31.0 98.4 13
32 31.1 12 30.6 98.4 14 30.9 99.4 9 30.1 96.8 13 31.3 100.6 13
33 31.1 12 30.6 98.4 14 30.8 99.0 9 30.0 96.5 13 31.1 100.0 13
34 31.3 12 30.5 97.4 14 31.2 99.7 9 30.3 96.8 13 30.8 98.4 13
35 31.6 12 30.6 96.8 14 30.7 97.2 9 30.8 97.5 13 30.3 95.9 13
36 32.0 12 30.6 95.6 14 31.7 99.1 9 31.3 97.8 13 29.8 93.1 12
37 32.0 12 30.1 94.1 14 31.9 99.7 9 30.9 96.6 13 29.7 92.8 12
38 31.7 12 30.9 97.5 14 31.6 99.7 9 31.2 98.4 13 30.3 95.6 12
39 31.8 12 31.1 97.8 14 31.8 100.0 9 31.3 98.4 13 31.7 99.7 11
40 32.8 9 31.3 95.4 12 32.1 97.9 8 31.2 95.1 12 31.2 95.1 11
TERM. SAC. 9 12 8 12 11
==========================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
===============================
50000 PPM
WEEK ----------------
AV.WT. PERCENT NO.
(GRAMS) OF CNTL (A)
==============================
B 18.6 97.4 15
1 18.6 97.4 15
2 20.8 96.7 15
3 22.0 100.5 15
4 22.7 100.4 15
5 23.6 99.2 15
6 23.8 96.7 15
7 24.9 98.8 15
8 24.6 94.6 15
9 25.5 97.0 15
10 26.2 95.6 15
11 26.8 95.0 15
12 27.0 94.7 15
13 27.4 95.1 15
14 27.6 95.2 15
15 28.1 95.3 15
16 27.8 94.2 15
17 28.6 97.9 15
18 28.6 96.9 15
19 28.4 97.6 15
20 28.9 97.3 15
21 29.4 97.4 14
22 28.5 93.8 14
23 28.4 92.2 14
24 27.9 90.9 14
25 28.0 90.0 14
26 27.2 88.3 14
27 29.0 92.7 12
28 29.7 94.3 12
29 30.0 95.5 12
30 30.9 97.2 11
31 30.9 98.1 11
32 31.0 99.7 11
33 31.2 100.3 11
34 30.5 97.4 11
35 31.1 98.4 11
36 31.6 98.8 11
37 31.2 97.5 11
38 31.3 98.7 11
39 31.2 98.1 11
40 31.7 96.6 10
TERM. SAC. 10
===============================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==========================================================================================================================
WEEK VEHICLE CONTROL 3125 PPM 6250 PPM 12500 PPM 25000 PPM
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
B 16.6 15 16.6 100.0 15 15.8 95.2 15 15.5 93.4 15 16.4 98.8 15
1 16.6 15 16.6 100.0 15 15.8 95.2 15 15.5 93.4 15 16.4 98.8 15
2 18.1 15 18.0 99.4 15 17.7 97.8 15 17.4 96.1 15 18.1 100.0 15
3 18.5 15 18.9 102.2 15 18.3 98.9 15 17.8 96.2 15 17.6 95.1 15
4 19.5 15 19.7 101.0 15 19.5 100.0 15 18.8 96.4 15 19.6 100.5 15
5 19.5 15 20.1 103.1 15 19.7 101.0 15 19.7 101.0 15 20.1 103.1 14
6 19.7 15 20.3 103.0 15 20.4 103.6 15 19.3 98.0 15 20.2 102.5 14
7 20.1 15 21.4 106.5 15 21.3 106.0 15 20.7 103.0 15 20.8 103.5 14
8 20.5 15 20.9 102.0 15 20.6 100.5 15 20.6 100.5 15 21.1 102.9 14
9 21.1 15 21.9 103.8 15 21.5 101.9 15 21.3 100.9 15 21.6 102.4 14
10 21.6 15 22.2 102.8 15 21.5 99.5 14 21.9 101.4 15 21.9 101.4 14
11 21.7 15 22.4 103.2 15 22.5 103.7 13 21.9 100.9 15 22.5 103.7 14
12 22.4 15 22.6 100.9 15 21.9 97.8 13 21.9 97.8 15 21.7 96.9 14
13 22.5 15 22.6 100.4 14 22.0 97.8 13 22.3 99.1 15 23.2 103.1 14
14 22.4 15 22.9 102.2 14 23.0 102.7 13 22.5 100.4 15 22.9 102.2 14
15 22.3 15 22.5 100.9 14 23.3 104.5 13 22.4 100.4 14 23.6 105.8 14
16 22.6 15 23.3 103.1 14 23.4 103.5 13 22.5 99.6 14 23.4 103.5 14
17 22.6 14 23.1 102.2 14 23.2 102.7 12 22.5 99.6 14 23.8 105.3 14
18 22.6 14 23.3 103.1 14 23.4 103.5 12 22.9 101.3 14 23.7 104.9 14
19 23.0 14 23.3 101.3 14 23.8 103.5 12 23.4 101.7 14 23.6 102.6 14
20 23.1 14 23.1 100.0 14 23.7 102.6 12 23.0 99.6 13 23.7 102.6 14
21 23.9 14 24.2 101.3 14 24.7 103.3 12 23.3 97.5 13 24.1 100.8 14
22 23.7 14 24.3 102.5 14 24.6 103.8 11 22.9 96.6 13 24.2 102.1 14
23 24.4 14 24.6 100.8 14 24.6 100.8 11 23.1 94.7 13 23.9 98.0 14
24 24.4 14 24.1 98.8 14 24.8 101.6 11 23.1 94.7 13 24.3 99.6 14
25 24.4 14 25.2 103.3 14 25.0 102.5 11 24.0 98.4 11 24.4 100.0 14
26 24.9 14 25.6 102.8 14 25.0 100.4 11 23.9 96.0 11 24.7 99.2 14
27 25.1 14 25.6 102.0 14 24.9 99.2 11 23.5 93.6 11 24.9 99.2 14
28 25.3 14 25.2 99.6 14 25.1 99.2 11 25.0 98.8 10 25.1 99.2 14
29 25.3 14 25.4 100.4 13 24.9 98.4 11 24.9 98.4 10 25.0 98.8 14
30 26.0 13 25.0 96.2 12 25.6 98.5 10 25.4 97.7 10 24.8 95.4 14
31 25.8 13 25.1 97.3 11 26.3 101.9 9 25.1 97.3 10 24.4 94.6 14
32 25.1 13 25.1 100.0 11 26.1 104.0 9 25.3 100.8 10 24.3 96.8 14
33 25.6 13 25.1 98.0 11 26.4 103.1 9 25.0 97.7 10 24.6 96.1 14
34 25.6 13 25.1 98.0 11 26.6 103.9 9 25.4 99.2 10 24.7 96.5 14
35 25.4 13 26.0 102.4 11 26.9 105.9 9 26.1 102.8 10 25.3 99.6 14
36 26.1 12 25.7 98.5 11 27.8 106.5 9 26.3 100.8 10 25.0 95.8 14
37 25.9 12 25.4 98.1 11 27.6 106.6 9 25.8 99.6 10 24.7 95.4 14
38 26.2 12 26.2 100.0 11 27.0 103.1 9 26.0 99.2 10 24.6 93.9 14
39 26.5 12 26.4 99.6 11 27.6 104.2 9 26.4 99.6 10 24.8 93.6 14
40 26.7 11 25.4 95.1 10 26.9 100.7 9 26.5 99.3 9 26.5 99.3 11
TERM. SAC. 11 10 9 9 11
==========================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
===============================
50000 PPM
WEEK ----------------
AV.WT. PERCENT NO.
(GRAMS) OF CNTL (A)
==============================
B 16.6 100.0 15
1 16.6 100.0 15
2 17.8 98.3 15
3 17.9 96.8 15
4 19.6 100.5 15
5 20.3 104.1 15
6 20.2 102.5 15
7 21.3 106.0 15
8 20.7 101.0 15
9 21.8 103.3 15
10 22.4 103.7 15
11 22.7 104.6 15
12 23.2 103.6 15
13 23.1 102.7 14
14 23.1 103.1 12
15 23.5 105.4 12
16 24.5 108.4 12
17 24.4 108.0 12
18 24.5 108.4 12
19 24.9 108.3 12
20 25.9 112.1 12
21 26.0 108.8 12
22 25.7 108.4 12
23 25.7 105.3 11
24 26.1 107.0 11
25 26.2 107.4 11
26 26.1 104.8 11
27 26.3 104.8 11
28 27.3 107.9 10
29 27.5 108.7 10
30 27.2 104.6 10
31 27.9 108.1 10
32 28.0 111.6 9
33 27.8 108.6 9
34 27.9 109.0 9
35 27.7 109.1 9
36 27.8 106.5 9
37 27.2 105.0 9
38 28.1 107.3 9
39 28.0 105.7 9
40 28.3 106.0 8
TERM. SAC. 8
===============================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.