TDMS Study 99033-01 Pathology Tables
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
FINAL #3 TG.AC MICE
Facility: BIORELIANCE
Chemical CAS #: 22839-47-0
Lock Date: 07/20/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 VEHICLE CONTROL
Include 002 3125 PPM
Include 003 6250 PPM
Include 004 12500 PPM
Include 005 25000 PPM
Include 006 50000 PPM
Include 008 VEHICLE CONTROL
Include 009 3125 PPM
Include 010 6250 PPM
Include 011 12500 PPM
Include 012 25000 PPM
Include 013 50000 PPM
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 0| 7| 7| 7| | |
| 2| 5| 5| 5| 5| 0| 5| 5| 0| 5| 5| 9| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + A + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Squamous Cell Papilloma | X X | 2 |
Squamous Cell Papilloma, Multiple | X X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 0| 7| 7| 7| | |
| 2| 5| 5| 5| 5| 0| 5| 5| 0| 5| 5| 9| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Odontogenic Tumor | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M M + + M M M M M M M | 4 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + M + I + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + M + + + | 14 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 0| 7| 7| 7| | |
| 2| 5| 5| 5| 5| 0| 5| 5| 0| 5| 5| 9| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Uterus | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + I M + + + + M + + + + | 12 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Vulva, Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 0| 7| 7| 7| | |
| 2| 5| 5| 5| 5| 0| 5| 5| 0| 5| 5| 9| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Skeletal Muscle | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | M M M M M M I M M M M M M M M | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolar/Bronchiolar Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + I + + + + + + + + + + + | 14 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 0| 7| 7| 7| | |
| 2| 5| 5| 5| 5| 0| 5| 5| 0| 5| 5| 9| 5| 5| 5| | |
_____________________________________________________________________________________________________________________ T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 1| 2| | |
DAY ON TEST | 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 0| 9| 7| | |
| 2| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 1| 6| 8| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
3125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X X X | 3 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + A A + + | 13 |
Squamous Cell Papilloma | X X X X X X | 6 |
Squamous Cell Papilloma, Multiple | X X X | 3 |
|__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + + A A + + | 12 |
|__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
Odontoma | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | A + + + + + + + + + + A A + + | 12 |
|__________________________________________________________________________|____________|
Adrenal Medulla | A + + + + + + + + + + A A + + | 12 |
|__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + I + + A I + | 11 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + A A + + | 13 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 1| 2| | |
DAY ON TEST | 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 0| 9| 7| | |
| 2| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 1| 6| 8| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
3125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Ovary | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + A A + + | 13 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + A + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + A A + + | 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + M + + + A A + + | 11 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + A + + + | 14 |
Leukemia Erythrocytic | X X X | 3 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + A + M + | 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + A A + + | 13 |
|__________________________________________________________________________|____________|
Skin | + + + | 3 |
Squamous Cell Papilloma | X X | 2 |
Vulva, Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | A + + + + + + + + + + A A + + | 12 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 1| 2| | |
DAY ON TEST | 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 0| 9| 7| | |
| 2| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 1| 6| 8| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
3125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
Leukemia Erythrocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + A + + + | 14 |
Leukemia Erythrocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | A + + + + + + + + + + A A + + | 12 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 0| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 0| 6| 4| 7| 1| 7| 7| 7| 7| 7| 7| 6| 0| 7| | |
| 5| 0| 1| 8| 5| 3| 5| 5| 5| 5| 5| 5| 7| 7| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
6250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + A + + + + + + + + + | 14 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + A + + + + + + + + + | 13 |
Squamous Cell Papilloma | X | 1 |
Squamous Cell Papilloma, Multiple | X X X | 3 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + A + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
Odontoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + A + A + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + A + A + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + M A + A + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + A + A + + M + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + A + A + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 0| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 0| 6| 4| 7| 1| 7| 7| 7| 7| 7| 7| 6| 0| 7| | |
| 5| 0| 1| 8| 5| 3| 5| 5| 5| 5| 5| 5| 7| 7| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
6250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Uterus | + + + A + A + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + A + + + + + + + M + | 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M A + A + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + A + A M + + M + + + + + | 11 |
|__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + | 14 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Thymus | + M + A + A + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + A + A + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Skin | + | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + A + A + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 0| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 0| 6| 4| 7| 1| 7| 7| 7| 7| 7| 7| 6| 0| 7| | |
| 5| 0| 1| 8| 5| 3| 5| 5| 5| 5| 5| 5| 7| 7| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
6250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Lung | + + + + + A + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + A + A + + + + + + + + + | 13 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 1| 1| 2| 0| 2| 2| 2| 1| 2| 2| 2| 1| 2| | |
DAY ON TEST | 7| 7| 3| 6| 7| 9| 7| 7| 7| 6| 7| 7| 7| 8| 7| | |
| 5| 5| 4| 5| 5| 7| 5| 5| 1| 5| 5| 5| 5| 4| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
12500 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Sarcoma Stromal, Metastatic, Uterus | X | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
Duct, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Squamous Cell Papilloma | X X X X X X X | 7 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + + + + + + | 14 |
|__________________________________________________________________________|____________|
Tooth | + + + + + | 5 |
Odontoma | X X X X X | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + A + A + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + A + A + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + M + + I + + + M + M + + I | 10 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 1| 1| 2| 0| 2| 2| 2| 1| 2| 2| 2| 1| 2| | |
DAY ON TEST | 7| 7| 3| 6| 7| 9| 7| 7| 7| 6| 7| 7| 7| 8| 7| | |
| 5| 5| 4| 5| 5| 7| 5| 5| 1| 5| 5| 5| 5| 4| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
12500 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Ovary | + + + A + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Uterus | + + + A + A + + A + + + + + + | 12 |
Sarcoma Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Pancreatic, Sarcoma Stromal, | | |
Metastatic, Uterus | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + A + A + + + M + + + + + | 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + A + I + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + A + + + + + + M + + + M | 12 |
Carcinoma, Metastatic, Salivary | | |
Glands | X | 1 |
|__________________________________________________________________________|____________|
Spleen | + + A + + A + + A + + + + + + | 12 |
|__________________________________________________________________________|____________|
Thymus | + + A M + M + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + A + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 1| 1| 2| 0| 2| 2| 2| 1| 2| 2| 2| 1| 2| | |
DAY ON TEST | 7| 7| 3| 6| 7| 9| 7| 7| 7| 6| 7| 7| 7| 8| 7| | |
| 5| 5| 4| 5| 5| 7| 5| 5| 1| 5| 5| 5| 5| 4| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
12500 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Brain | + + A + + A + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Carcinoma, Metastatic, Salivary | | |
Glands | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + A + + + + + + + + + | 14 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| | |
| 5| 7| 0| 5| 5| 5| 5| 9| 5| 5| 5| 5| 3| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
25000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + A + + | 14 |
Squamous Cell Papilloma | X X X | 3 |
Squamous Cell Papilloma, Multiple | X X X X | 4 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
Tooth | + + + + + | 5 |
Odontoma | X X X X X | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + M + + | 14 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + I + I + I + + + + + A + + | 11 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + A + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| | |
| 5| 7| 0| 5| 5| 5| 5| 9| 5| 5| 5| 5| 3| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
25000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Uterus | + + + + + + + + + + + + A + + | 14 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + M + I + + + A + + | 11 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + A + + | 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
Skin | + + + | 3 |
Vulva, Squamous Cell Papilloma | X X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + A + + | 14 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + A + + | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | |
DAY ON TEST | 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| | |
| 5| 7| 0| 5| 5| 5| 5| 9| 5| 5| 5| 5| 3| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
25000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + A + + | 14 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 0| 2| 2| 2| 2| 2| 0| 2| 1| 1| 0| 2| 2| 2| | |
DAY ON TEST | 7| 9| 7| 7| 7| 7| 6| 7| 7| 8| 5| 9| 7| 1| 7| | |
| 5| 2| 5| 5| 5| 5| 9| 9| 5| 4| 1| 2| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50000 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + A + + + + + + + M + A + A + | 11 |
|__________________________________________________________________________|____________|
Gallbladder | M A + M M + + A + M A M + A + | 6 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + A + + A A + A + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + A + + A A + A + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + A + + A A + A + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + A + + A A + A + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + A + + A A + A + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + A + + A A + A + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + A + + + | 14 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + A + + + | 13 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + A + A + | 13 |
Duct, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + A A + A + | 11 |
Squamous Cell Papilloma | X X X X X | 5 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + A + + A A + A + | 10 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 0| 2| 2| 2| 2| 2| 0| 2| 1| 1| 0| 2| 2| 2| | |
DAY ON TEST | 7| 9| 7| 7| 7| 7| 6| 7| 7| 8| 5| 9| 7| 1| 7| | |
| 5| 2| 5| 5| 5| 5| 9| 9| 5| 4| 1| 2| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50000 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Tooth | + | 1 |
Odontogenic Tumor | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + A M + + + + A + + + A + A + | 10 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + M + + + + + + + + + | 14 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + A + + A A + + + | 11 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M M M M M + I M M M A M + M + | 3 |
|__________________________________________________________________________|____________|
Pituitary Gland | + M + I + + + M + + A M + A + | 9 |
|__________________________________________________________________________|____________|
Thyroid Gland | + A + + M + + + + + A A + + + | 11 |
Leukemia Erythrocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 0| 2| 2| 2| 2| 2| 0| 2| 1| 1| 0| 2| 2| 2| | |
DAY ON TEST | 7| 9| 7| 7| 7| 7| 6| 7| 7| 8| 5| 9| 7| 1| 7| | |
| 5| 2| 5| 5| 5| 5| 9| 9| 5| 4| 1| 2| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50000 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + M M A + A + | 10 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + A + + + | 14 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + A + + + + | 14 |
|__________________________________________________________________________|____________|
Vagina | + A + + + + + A + + + A + A + | 11 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + A + + + A + + + | 12 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + A + + + A + A + | 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + + + + + A + + A A M A + | 9 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + A + + + + + A + + M A + + + | 11 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + A + + + | 14 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Thymus | + A + + + + + + + + A A + A + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + A M + + + + A + + + A + + + | 11 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 0| 2| 2| 2| 2| 2| 0| 2| 1| 1| 0| 2| 2| 2| | |
DAY ON TEST | 7| 9| 7| 7| 7| 7| 6| 7| 7| 8| 5| 9| 7| 1| 7| | |
| 5| 2| 5| 5| 5| 5| 9| 9| 5| 4| 1| 2| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50000 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + A + | 14 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + A + + + + + A + + + A + A + | 11 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | M M I M M M M M I M M M M M I | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + A + + + | 14 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + A + + + A + + + | 13 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Trachea | + A + + + + + A + + A A + A + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + A + + + + + A + + A A + A + | 10 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + M + + + + + + M + + + | 13 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 0| 2| 2| 2| 2| 2| 0| 2| 1| 1| 0| 2| 2| 2| | |
DAY ON TEST | 7| 9| 7| 7| 7| 7| 6| 7| 7| 8| 5| 9| 7| 1| 7| | |
| 5| 2| 5| 5| 5| 5| 9| 9| 5| 4| 1| 2| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50000 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + A + + + + + + + + + + + + + | 14 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + A + + A A + A + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 9| | |
| 4| 4| 4| 6| 4| 1| 4| 4| 4| 4| 4| 1| 1| 3| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + M + + + A + | 13 |
|__________________________________________________________________________|____________|
Gallbladder | + + + A M + + + M + + + + A A | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + A A | 12 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + A A | 12 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + + A A | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + A A | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + A A | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + + A A | 12 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + A A | 13 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + A A | 13 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + A A | 12 |
Squamous Cell Papilloma | X X X X | 4 |
Squamous Cell Papilloma, Multiple | X X X X | 4 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + A A | 12 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + M A A | 12 |
|__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 9| | |
| 4| 4| 4| 6| 4| 1| 4| 4| 4| 4| 4| 1| 1| 3| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Odontogenic Tumor | X X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + M + + + A A | 12 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + A A | 13 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + A A | 13 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + A A | 13 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M + I M M + M M M A A | 5 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + I + + + + I I I + + A A | 9 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + + + + M + | 13 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + M + + + + + A A | 12 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + A A | 13 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 9| | |
| 4| 4| 4| 6| 4| 1| 4| 4| 4| 4| 4| 1| 1| 3| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + A A | 13 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + A M | 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A A | 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + I I M A | 11 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + A + | 14 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + A + + + + + + + + + A A | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + A A | 13 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 9| | |
| 4| 4| 4| 6| 4| 1| 4| 4| 4| 4| 4| 1| 1| 3| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + I I I I I + I + M M M I A A | 3 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + A A | 13 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + A + + + + + + + + + A A | 12 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + A + | 14 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + A A | 13 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 1| 1| 4| 4| 4| 8| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
3125 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Squamous Cell Papilloma | X | 1 |
Squamous Cell Papilloma, Multiple | X X X X | 4 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
Odontogenic Tumor | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + I + + + + + | 13 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 1| 1| 4| 4| 4| 8| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
3125 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Penis | + | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + M + M + + | 13 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + | 14 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + | 2 |
Squamous Cell Papilloma | X X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 1| 1| 4| 4| 4| 8| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
3125 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 1| 1| 2| 2| 1| 2| 0| 2| 2| 2| 1| 2| 2| | |
DAY ON TEST | 7| 7| 3| 9| 7| 7| 5| 7| 7| 7| 7| 0| 3| 7| 7| | |
| 1| 4| 2| 7| 4| 4| 0| 4| 8| 4| 4| 7| 8| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
6250 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + A + + + + + + | 14 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
Duct, Carcinoma | X X | 2 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + + + A + + + + + + | 13 |
Squamous Cell Papilloma | X | 1 |
Squamous Cell Papilloma, Multiple | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + A + + + + + + | 13 |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
Odontogenic Tumor | X X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + A + + + + + A + + + + + + | 13 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + A + + + + + A + + + + + + | 13 |
|__________________________________________________________________________|____________|
Pituitary Gland | I + M + + + I I A M I + M I + | 6 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + A + + + + + M + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 1| 1| 2| 2| 1| 2| 0| 2| 2| 2| 1| 2| 2| | |
DAY ON TEST | 7| 7| 3| 9| 7| 7| 5| 7| 7| 7| 7| 0| 3| 7| 7| | |
| 1| 4| 2| 7| 4| 4| 0| 4| 8| 4| 4| 7| 8| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
6250 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + A M + + + + + | 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + A + + + + + + | 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + + + + + M + + + + + + | 11 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Spleen | + + A + + + + + A + + + + + + | 13 |
Leukemia Erythrocytic | X | 1 |
|__________________________________________________________________________|____________|
Thymus | + + M + + + + + M + + M + + + | 12 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 1| 1| 2| 2| 1| 2| 0| 2| 2| 2| 1| 2| 2| | |
DAY ON TEST | 7| 7| 3| 9| 7| 7| 5| 7| 7| 7| 7| 0| 3| 7| 7| | |
| 1| 4| 2| 7| 4| 4| 0| 4| 8| 4| 4| 7| 8| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
6250 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + A + + + + + A + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + A + + + + + + | 14 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
Leukemia Erythrocytic | X | 1 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + A + + + + + A + + + + + + | 13 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| | |
| 1| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
12500 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X X | 2 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + A + + | 14 |
Squamous Cell Papilloma | X X X | 3 |
Squamous Cell Papilloma, Multiple | X X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
Odontogenic Tumor | X X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + I + + + I + + I + + M + + | 11 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + A + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| | |
| 1| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
12500 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + A + + | 14 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + A + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + M M + I + + + + M | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X X | 2 |
|__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + A + + | 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + A + + | 14 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| | |
| 1| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
12500 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X | 1 |
Leukemia Erythrocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| | |
DAY ON TEST | 9| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 3| | |
| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 1| 4| 4| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
25000 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | A + + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
Duct, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + + + + + + + + + + + + | 14 |
Squamous Cell Papilloma | X X X X | 4 |
Squamous Cell Papilloma, Multiple | X X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
Odontogenic Tumor | X X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pituitary Gland | A + + M + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Thyroid Gland | A + + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| | |
DAY ON TEST | 9| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 3| | |
| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 1| 4| 4| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
25000 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | A + + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | A + + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Thymus | I + + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| | |
DAY ON TEST | 9| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 3| | |
| 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 1| 4| 4| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
25000 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L |
PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Brain | A + + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | A + + + + + + + + + + + + + + | 14 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | A + + + + + + + + + + + + + + | 14 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 8| 7| 7| 7| 7| 4| 8| | |
| 4| 4| 4| 4| 0| 4| 4| 1| 0| 4| 4| 4| 4| 1| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Gallbladder | M + M + + + + + + + + + + A + | 12 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + A + | 14 |
Duct, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + A + | 14 |
Squamous Cell Papilloma | X X X X X | 5 |
Squamous Cell Papilloma, Multiple | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + M + + A + | 13 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 8| 7| 7| 7| 7| 4| 8| | |
| 4| 4| 4| 4| 0| 4| 4| 1| 0| 4| 4| 4| 4| 1| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Tooth | + + + + + + | 6 |
Odontogenic Tumor | X X X X X X | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + I A + | 13 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + M A + | 13 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + M M M + M + M M M M + A M | 4 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + I + M + + + + + I + I A I | 9 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + A + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 8| 7| 7| 7| 7| 4| 8| | |
| 4| 4| 4| 4| 0| 4| 4| 1| 0| 4| 4| 4| 4| 1| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Penis | + | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + M + + + + + + + M + + A + | 12 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + A + | 14 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A + | 14 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + A M | 13 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + A M | 12 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 8| 7| 7| 7| 7| 4| 8| | |
| 4| 4| 4| 4| 0| 4| 4| 1| 0| 4| 4| 4| 4| 1| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + M M + M I M M M M M M M M M | 2 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + A + | 14 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + A + | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + A + | 14 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 15 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + A + | 14 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 99033-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:25:49
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 8| 7| 7| 7| 7| 4| 8| | |
| 4| 4| 4| 4| 0| 4| 4| 1| 0| 4| 4| 4| 4| 1| 0| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + A + | 14 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
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---------- END OF REPORT ----------
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