TDMS Study 99033-01 Pathology Tables
NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 FINAL #3 TG.AC MICE Facility: BIORELIANCE Chemical CAS #: 22839-47-0 Lock Date: 07/20/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include 001 VEHICLE CONTROL Include 002 3125 PPM Include 003 6250 PPM Include 004 12500 PPM Include 005 25000 PPM Include 006 50000 PPM Include 008 VEHICLE CONTROL Include 009 3125 PPM Include 010 6250 PPM Include 011 12500 PPM Include 012 25000 PPM Include 013 50000 PPM Page 1 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 0| 7| 7| 7| | | | 2| 5| 5| 5| 5| 0| 5| 5| 0| 5| 5| 9| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + A + + + | 14 | Inflammation, Chronic Active | 2 | 1 2.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Inflammation, Acute, Focal | 2 | 1 2.0| Inflammation, Chronic Active, Focal | 1 2 | 2 1.5| Necrosis, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Tongue | + + + + + + + + + + + + + + + | 15 | Ulcer | 1 | 1 1.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 0| 7| 7| 7| | | | 2| 5| 5| 5| 5| 0| 5| 5| 0| 5| 5| 9| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Tooth | + + + + | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | Accessory Adrenal Cortical Nodule | 1 | 1 1.0| Atrophy | 1 3 2 | 3 2.0| Subcapsular, Hyperplasia, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 | 12 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic | 3 2 2 2 3 1 2 2 3 2 3 1 | 12 2.2| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Parathyroid Gland | M + M + M M + + M M M M M M M | 4 | |__________________________________________________________________________|____________| Pituitary Gland | + + + M + I + + + + + + + + + | 13 | Cyst | 2 X | 2 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | Follicle, Cyst | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + + | 2 | Pigmentation | 1 | 1 1.0| Abdominal, Fat, Necrosis, Focal | 4 | 1 4.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 0| 7| 7| 7| | | | 2| 5| 5| 5| 5| 0| 5| 5| 0| 5| 5| 9| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + M + + + | 14 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 15 | Atrophy | 2 1 | 2 1.5| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + | 15 | Endometrium, Hyperplasia, Cystic | 1 2 1 1 2 2 1 2 3 1 | 10 1.6| |__________________________________________________________________________|____________| Vagina | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node | + | 1 | Renal, Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | Hyperplasia, Plasma Cell | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + I M + + + + M + + + + | 12 | Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 1 2 1 1 3 1 3 2 1 1 | 10 1.6| Pigmentation | 1 1 1 2 2 1 1 1 2 1 | 10 1.3| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | Atrophy, Diffuse | 4 3 4 | 3 3.7| Atrophy, Focal | 1 2 | 2 1.5| _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 0| 7| 7| 7| | | | 2| 5| 5| 5| 5| 0| 5| 5| 0| 5| 5| 9| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | M M M M M M I M M M M M M M M | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Hemorrhage, Focal | 1 | 1 1.0| Infiltration Cellular, Focal, | | | Lymphocyte | 1 | 1 1.0| Inflammation, Chronic Active, Focal | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 0| 7| 7| 7| | | | 2| 5| 5| 5| 5| 0| 5| 5| 0| 5| 5| 9| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | Retina, Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | 15 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | Infiltration Cellular, Focal, | | | Lymphocyte | 1 | 1 1.0| Nephropathy | 1 | 1 1.0| Renal Tubule, Dilatation, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + I + + + + + + + + + + + | 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 1| 2| | | DAY ON TEST | 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 0| 9| 7| | | | 2| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 1| 6| 8| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 3125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Infiltration Cellular, Focal, | | | Lymphocyte | 1 | 1 1.0| Hepatocyte, Necrosis, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + A A + + | 13 | |__________________________________________________________________________|____________| Stomach, Glandular | A + + + + + + + + + + A A + + | 12 | |__________________________________________________________________________|____________| Tooth | + + + + | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | A + + + + + + + + + + A A + + | 12 | Atrophy | 1 3 | 2 2.0| Subcapsular, Hyperplasia, Focal | 1 1 1 1 1 1 | 6 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic | 1 1 2 1 2 1 3 1 3 | 9 1.7| |__________________________________________________________________________|____________| Adrenal Medulla | A + + + + + + + + + + A A + + | 12 | |__________________________________________________________________________|____________| Pituitary Gland | + M + + + + + + + I + + A I + | 11 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + A A + + | 13 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 1| 2| | | DAY ON TEST | 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 0| 9| 7| | | | 2| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 1| 6| 8| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 3125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + A A + + | 13 | Endometrium, Hyperplasia, Cystic | 2 2 1 1 2 1 2 2 | 8 1.6| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + A + + + | 14 | Hyperplasia | 2 3 | 2 2.5| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + A A + + | 13 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + + + + M + + + A A + + | 11 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + A + + + | 14 | Accessory Spleen | 2 | 1 2.0| Hematopoietic Cell Proliferation | 2 1 1 3 | 4 1.8| Pigmentation | 1 1 2 1 1 1 1 1 1 1 | 10 1.1| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + A + M + | 13 | Atrophy, Diffuse | 4 | 1 4.0| Atrophy, Focal | 2 | 1 2.0| Hyperplasia, Diffuse | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + A A + + | 13 | |__________________________________________________________________________|____________| Skin | + + + | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 1| 2| | | DAY ON TEST | 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 0| 9| 7| | | | 2| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 1| 6| 8| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 3125 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | A + + + + + + + + + + A A + + | 12 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + A + + + | 14 | Alveolar Epithelium, Hyperplasia, | | | Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | A + + + + + + + + + + A A + + | 12 | Renal Tubule, Dilatation, Focal | 1 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | DAY ON TEST | 7| 0| 6| 4| 7| 1| 7| 7| 7| 7| 7| 7| 6| 0| 7| | | | 5| 0| 1| 8| 5| 3| 5| 5| 5| 5| 5| 5| 7| 7| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 6250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + A + + + + + + + + + | 14 | Necrosis | 1 | 1 1.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + A + A + + + + + + + + + | 13 | Infiltration Cellular, Focal, | | | Lymphocyte | 1 | 1 1.0| Muscularis, Inflammation, Acute, | | | Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + A + A + + + + + + + + + | 13 | |__________________________________________________________________________|____________| Tooth | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + A + A + + + + + + + + + | 13 | Atrophy | 1 | 1 1.0| Subcapsular, Hyperplasia, Focal | 1 1 1 1 1 1 | 6 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic | 3 3 3 2 1 2 | 6 2.3| |__________________________________________________________________________|____________| Adrenal Medulla | + + + A + A + + + + + + + + + | 13 | |__________________________________________________________________________|____________| Pituitary Gland | + + M A + A + + + + + + + + + | 12 | |__________________________________________________________________________|____________| Thyroid Gland | + + + A + A + + M + + + + + + | 12 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | DAY ON TEST | 7| 0| 6| 4| 7| 1| 7| 7| 7| 7| 7| 7| 6| 0| 7| | | | 5| 0| 1| 8| 5| 3| 5| 5| 5| 5| 5| 5| 7| 7| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 6250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + A + A + + + + + + + + + | 13 | Atrophy | 3 | 1 3.0| |__________________________________________________________________________|____________| Uterus | + + + A + A + + + + + + + + + | 13 | Endometrium, Hyperplasia, Cystic | 2 1 2 2 1 1 1 1 2 | 9 1.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + A + + + + + + + M + | 12 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M A + A + + + + + + + + + | 12 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + A + A M + + M + + + + + | 11 | |__________________________________________________________________________|____________| Spleen | + + + + + A + + + + + + + + + | 14 | Hematopoietic Cell Proliferation | 2 2 1 2 2 1 1 | 7 1.6| Pigmentation | 1 2 1 1 1 1 1 1 1 1 1 | 11 1.1| |__________________________________________________________________________|____________| Thymus | + M + A + A + + + + + + + + + | 12 | Atrophy, Diffuse | 3 | 1 3.0| Atrophy, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + A + A + + + + + + + + + | 13 | |__________________________________________________________________________|____________| Skin | + | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | DAY ON TEST | 7| 0| 6| 4| 7| 1| 7| 7| 7| 7| 7| 7| 6| 0| 7| | | | 5| 0| 1| 8| 5| 3| 5| 5| 5| 5| 5| 5| 7| 7| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 6250 PPM | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | Brain | + + + A + A + + + + + + + + + | 13 | Cerebellum, Corpus Callosum, Pons, | | | Vacuolization Cytoplasmic, Focal| 1 | 1 1.0| Cortex, Cerebrum, Neuron, Necrosis | 1 | 1 1.0| Pyramidal Cell, Hippocampus, Necrosis| 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + A + + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + A + A + + + + + + + + + | 13 | Renal Tubule, Dilatation, Focal | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 1| 2| 0| 2| 2| 2| 1| 2| 2| 2| 1| 2| | | DAY ON TEST | 7| 7| 3| 6| 7| 9| 7| 7| 7| 6| 7| 7| 7| 8| 7| | | | 5| 5| 4| 5| 5| 7| 5| 5| 1| 5| 5| 5| 5| 4| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 12500 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Infiltration Cellular, Focal, | | | Polymorphonuclear | 1 | 1 1.0| Hepatocyte, Necrosis, Focal | 1 1 1 1 | 4 1.0| |__________________________________________________________________________|____________| Salivary Glands | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + A + + + + + + | 14 | |__________________________________________________________________________|____________| Tooth | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + A + A + + + + + + + + + | 13 | Atrophy | 1 1 1 1 | 4 1.0| Subcapsular, Hyperplasia, Focal | 1 1 1 1 1 | 5 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic | 1 1 3 2 2 1 3 2 | 8 1.9| |__________________________________________________________________________|____________| Adrenal Medulla | + + + A + A + + + + + + + + + | 13 | |__________________________________________________________________________|____________| Pituitary Gland | + + M + + I + + + M + M + + I | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 1| 2| 0| 2| 2| 2| 1| 2| 2| 2| 1| 2| | | DAY ON TEST | 7| 7| 3| 6| 7| 9| 7| 7| 7| 6| 7| 7| 7| 8| 7| | | | 5| 5| 4| 5| 5| 7| 5| 5| 1| 5| 5| 5| 5| 4| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 12500 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + A + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Uterus | + + + A + A + + A + + + + + + | 12 | Cyst, Focal | 3 | 1 3.0| Endometrium, Hyperplasia, Cystic | 1 1 2 3 1 1 2 1 1 2 | 10 1.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + A + A + + + M + + + + + | 12 | Hyperplasia | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + A + + A + I + + + + + + + | 12 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + A + + + + + + M + + + M | 12 | |__________________________________________________________________________|____________| Spleen | + + A + + A + + A + + + + + + | 12 | Hematopoietic Cell Proliferation | 2 3 2 1 1 1 | 6 1.7| Pigmentation | 1 2 2 1 1 1 1 1 1 1 | 10 1.2| |__________________________________________________________________________|____________| Thymus | + + A M + M + + + + + + + + + | 12 | Atrophy, Diffuse | 4 3 | 2 3.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + A + + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 1| 2| 0| 2| 2| 2| 1| 2| 2| 2| 1| 2| | | DAY ON TEST | 7| 7| 3| 6| 7| 9| 7| 7| 7| 6| 7| 7| 7| 8| 7| | | | 5| 5| 4| 5| 5| 7| 5| 5| 1| 5| 5| 5| 5| 4| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 12500 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | Brain | + + A + + A + + + + + + + + + | 13 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Perivascular, Infiltration Cellular, | | | Lymphocyte | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + A + + + + + + + + + | 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | DAY ON TEST | 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| | | | 5| 7| 0| 5| 5| 5| 5| 9| 5| 5| 5| 5| 3| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 25000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + A + + | 14 | Inflammation, Acute, Focal | 1 | 1 1.0| Inflammation, Chronic Active, Focal | 1 | 1 1.0| Hepatocyte, Necrosis, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + A + + | 14 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + A + + | 14 | |__________________________________________________________________________|____________| Tooth | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + A + + | 14 | Atrophy | 2 1 2 1 2 | 5 1.6| Capsule, Inflammation, Acute, Focal | 2 | 1 2.0| Subcapsular, Hyperplasia, Focal | 1 1 1 1 1 1 | 6 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic | 4 2 2 2 2 3 2 2 3 | 9 2.4| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + M + + | 14 | |__________________________________________________________________________|____________| Pituitary Gland | + + I + I + I + + + + + A + + | 11 | Pars Intermedia, Hypertrophy | 2 | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + A + + | 14 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | DAY ON TEST | 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| | | | 5| 7| 0| 5| 5| 5| 5| 9| 5| 5| 5| 5| 3| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 25000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + A + + | 14 | Cyst, Focal | 1 | 1 1.0| Hemorrhage, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + A + + | 14 | Hydrometra | 1 | 1 1.0| Endometrium, Hyperplasia, Cystic | 2 1 1 2 3 2 2 3 2 1 | 10 1.9| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + A + + | 14 | Hyperplasia | 3 4 | 2 3.5| Inflammation, Acute, Focal | 3 | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + A + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + + + M + I + + + A + + | 11 | Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + A + + | 14 | Hematopoietic Cell Proliferation | 4 2 1 4 2 1 1 1 | 8 2.0| Pigmentation | 1 1 2 1 1 2 1 1 1 1 2 | 11 1.3| |__________________________________________________________________________|____________| Thymus | + M + + + + + + + + + + A + + | 13 | Atrophy, Diffuse | 4 4 | 2 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + A + + | 14 | |__________________________________________________________________________|____________| Skin | + + + | 3 | Lip, Control Epidermis, Hyperplasia, | | | Focal | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | DAY ON TEST | 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| | | | 5| 7| 0| 5| 5| 5| 5| 9| 5| 5| 5| 5| 3| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 25000 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + A + + | 14 | Abscess, Focal | 3 | 1 3.0| Inflammation, Acute, Focal | 3 | 1 3.0| Medulla, Vacuolization Cytoplasmic | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + A + + | 14 | Perivascular, Infiltration Cellular, | | | Lymphocyte | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + A + + | 14 | Inflammation, Acute, Focal | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 0| 2| 2| 2| 2| 2| 0| 2| 1| 1| 0| 2| 2| 2| | | DAY ON TEST | 7| 9| 7| 7| 7| 7| 6| 7| 7| 8| 5| 9| 7| 1| 7| | | | 5| 2| 5| 5| 5| 5| 9| 9| 5| 4| 1| 2| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 50000 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + A + + + + + + + M + A + A + | 11 | |__________________________________________________________________________|____________| Gallbladder | M A + M M + + A + M A M + A + | 6 | |__________________________________________________________________________|____________| Intestine Large, Colon | + A + + + + + A + + A A + A + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + A + + A A + A + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + A + + A A + A + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + + + A + + A A + A + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + A + + A A + A + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + A + + A A + A + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + A + + + | 14 | Inflammation, Acute, Focal | 1 1 | 2 1.0| Inflammation, Chronic Active, Focal | 1 | 1 1.0| Necrosis, Focal | 2 1 1 2 | 4 1.5| |__________________________________________________________________________|____________| Pancreas | + A + + + + + + + + + A + + + | 13 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + A + A + | 13 | |__________________________________________________________________________|____________| Stomach, Forestomach | + A + + + + + + + + A A + A + | 11 | |__________________________________________________________________________|____________| Stomach, Glandular | + A + + + + + A + + A A + A + | 10 | |__________________________________________________________________________|____________| Tongue | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 0| 2| 2| 2| 2| 2| 0| 2| 1| 1| 0| 2| 2| 2| | | DAY ON TEST | 7| 9| 7| 7| 7| 7| 6| 7| 7| 8| 5| 9| 7| 1| 7| | | | 5| 2| 5| 5| 5| 5| 9| 9| 5| 4| 1| 2| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 50000 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + A M + + + + A + + + A + A + | 10 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | Atrophy | 1 1 2 2 1 | 5 1.4| Subcapsular, Hyperplasia, Focal | 1 1 1 1 1 1 | 6 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic | 1 1 2 1 2 1 1 2 | 8 1.4| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + M + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Islets, Pancreatic | + A + + + + + A + + A A + + + | 11 | |__________________________________________________________________________|____________| Parathyroid Gland | M M M M M + I M M M A M + M + | 3 | |__________________________________________________________________________|____________| Pituitary Gland | + M + I + + + M + + A M + A + | 9 | |__________________________________________________________________________|____________| Thyroid Gland | + A + + M + + + + + A A + + + | 11 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + M + + + + + + M M A + A + | 10 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + A + + + + | 14 | Endometrium, Hyperplasia, Cystic | 1 1 2 2 2 1 1 1 1 2 | 10 1.4| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 0| 2| 2| 2| 2| 2| 0| 2| 1| 1| 0| 2| 2| 2| | | DAY ON TEST | 7| 9| 7| 7| 7| 7| 6| 7| 7| 8| 5| 9| 7| 1| 7| | | | 5| 2| 5| 5| 5| 5| 9| 9| 5| 4| 1| 2| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 50000 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Vagina | + A + + + + + A + + + A + A + | 11 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + A + + + + + A + + + A + + + | 12 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + A + + + A + A + | 12 | Hyperplasia, Plasma Cell | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + A + + + + + A + + A A M A + | 9 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + A + + + + + A + + M A + + + | 11 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + A + + + | 14 | Hematopoietic Cell Proliferation | 1 1 2 1 1 | 5 1.2| Pigmentation | 1 1 1 1 1 1 1 1 1 | 9 1.0| |__________________________________________________________________________|____________| Thymus | + A + + + + + + + + A A + A + | 11 | Atrophy, Diffuse | 3 4 | 2 3.5| Atrophy, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + A M + + + + A + + + A + + + | 11 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + A + | 14 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 0| 2| 2| 2| 2| 2| 0| 2| 1| 1| 0| 2| 2| 2| | | DAY ON TEST | 7| 9| 7| 7| 7| 7| 6| 7| 7| 8| 5| 9| 7| 1| 7| | | | 5| 2| 5| 5| 5| 5| 9| 9| 5| 4| 1| 2| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 50000 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + A + + + + + A + + + A + A + | 11 | Cortex, Cerebrum, Degeneration, Focal| 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | M M I M M M M M I M M M M M I | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Nose | + + + + + + + A + + + A + + + | 13 | |__________________________________________________________________________|____________| Trachea | + A + + + + + A + + A A + A + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + A + + + + + A + + A A + A + | 10 | Retina, Atrophy | 3 3 3 3 3 3 3 3 3 3 | 10 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + | 15 | Inflammation, Chronic Active | 1 | 1 1.0| |__________________________________________________________________________|____________| Zymbal's Gland | + + + + M + + + + + + M + + + | 13 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + A + + + + + + + + + + + + + | 14 | Mineralization, Focal | 1 | 1 1.0| Nephropathy | 1 | 1 1.0| Renal Tubule, Dilatation, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + A + + + + + A + + A A + A + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 9| | | | 4| 4| 4| 6| 4| 1| 4| 4| 4| 4| 4| 1| 1| 3| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + M + + + A + | 13 | |__________________________________________________________________________|____________| Gallbladder | + + + A M + + + M + + + + A A | 10 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Infiltration Cellular, Focal, | | | Lymphocyte | 2 | 1 2.0| Inflammation, Acute, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + A A | 13 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + A A | 13 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + A + + + + + + + + + A A | 12 | Epithelium, Hyperplasia | 1 | 1 1.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| Tongue | + + + + + + + + + + + + M A A | 12 | |__________________________________________________________________________|____________| Tooth | + + + + | 4 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 9| | | | 4| 4| 4| 6| 4| 1| 4| 4| 4| 4| 4| 1| 1| 3| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + M + + + A A | 12 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + A A | 13 | Atrophy | 2 2 3 2 2 2 2 2 2 2 | 10 2.1| Hypertrophy, Focal | 1 1 1 1 1 1 1 1 1 | 9 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + A A | 13 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + A A | 13 | |__________________________________________________________________________|____________| Parathyroid Gland | + M + + M + I M M + M M M A A | 5 | |__________________________________________________________________________|____________| Pituitary Gland | + + + I + + + + I I I + + A A | 9 | |__________________________________________________________________________|____________| Thyroid Gland | + + + A + + + + + + + + + M + | 13 | Follicle, Cyst | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | Unilateral, Aspermia | X | 1 | Unilateral, Cyst | 3 | 1 3.0| Unilateral, Duct, Hyperplasia, | | | Regenerative | 2 | 1 2.0| |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + M + + + + + A A | 12 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 9| | | | 4| 4| 4| 6| 4| 1| 4| 4| 4| 4| 4| 1| 1| 3| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Cyst | 2 | 1 2.0| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + A A | 13 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + A A | 13 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | Unilateral, Cyst | 1 | 1 1.0| Unilateral, Germinal Epithelium, | | | Degeneration | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M + + + + + + + + A M | 12 | Hyperplasia, Plasma Cell | 3 | 1 3.0| Necrosis | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + A A | 13 | Necrosis | 1 | 1 1.0| |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + I I M A | 11 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + A + | 14 | Hematopoietic Cell Proliferation | 3 1 1 | 3 1.7| Pigmentation | 1 1 1 1 1 1 1 1 1 | 9 1.0| |__________________________________________________________________________|____________| Thymus | + + + A + + + + + + + + + A A | 12 | Atrophy, Diffuse | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 9| | | | 4| 4| 4| 6| 4| 1| 4| 4| 4| 4| 4| 1| 1| 3| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + A A | 13 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + I I I I I + I + M M M I A A | 3 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + A A | 13 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + A + + + + + + + + + A A | 12 | Retina, Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 | 12 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + A + | 14 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 9| | | | 4| 4| 4| 6| 4| 1| 4| 4| 4| 4| 4| 1| 1| 3| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Kidney | + + + + + + + + + + + + + + + | 15 | Nephropathy | 1 1 1 | 3 1.0| Renal Tubule, Dilatation, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + A A | 13 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| | | | 4| 4| 4| 4| 4| 4| 4| 4| 1| 1| 4| 4| 4| 8| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 3125 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Tooth | + + + + | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | Atrophy | 2 2 1 1 1 1 1 2 3 2 2 1 | 12 1.6| Hypertrophy, Focal | 1 1 1 1 1 | 5 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + M + + + + + I + + + + + | 13 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | Bilateral, Aspermia | X | 1 | Unilateral, Aspermia | X X X | 3 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| | | | 4| 4| 4| 4| 4| 4| 4| 4| 1| 1| 4| 4| 4| 8| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 3125 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Penis | + | 1 | |__________________________________________________________________________|____________| Preputial Gland | + | 1 | Cyst | 2 | 1 2.0| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + | 15 | Inflammation, Acute, Focal | 3 | 1 3.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | Bilateral, Germinal Epithelium, | | | Degeneration | 3 3 | 2 3.0| Unilateral, Cyst | 2 3 | 2 2.5| Unilateral, Germinal Epithelium, | | | Degeneration | 3 3 | 2 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | Hyperplasia | 1 3 | 2 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + M + M + + | 13 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 1 1 1 | 3 1.0| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 | 12 1.0| Lymphoid Follicle, Depletion Cellular| 1 | 1 1.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + | 14 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| | | | 4| 4| 4| 4| 4| 4| 4| 4| 1| 1| 4| 4| 4| 8| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 3125 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Skin | + + | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Hemorrhage, Focal | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 1| 2| 2| 1| 2| 0| 2| 2| 2| 1| 2| 2| | | DAY ON TEST | 7| 7| 3| 9| 7| 7| 5| 7| 7| 7| 7| 0| 3| 7| 7| | | | 1| 4| 2| 7| 4| 4| 0| 4| 8| 4| 4| 7| 8| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 6250 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + A + + + + + + | 14 | |__________________________________________________________________________|____________| Salivary Glands | + + | 2 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + A + + + + + A + + + + + + | 13 | |__________________________________________________________________________|____________| Stomach, Glandular | + + A + + + + + A + + + + + + | 13 | |__________________________________________________________________________|____________| Tooth | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + A + + + + + A + + + + + + | 13 | Atrophy | 1 3 1 2 1 1 1 1 | 8 1.4| Hypertrophy, Focal | 1 1 1 1 1 | 5 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + A + + + + + A + + + + + + | 13 | |__________________________________________________________________________|____________| Pituitary Gland | I + M + + + I I A M I + M I + | 6 | |__________________________________________________________________________|____________| Thyroid Gland | + + A + + + + + M + + + + + + | 13 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | + | 1 | Cyst | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 1| 2| 2| 1| 2| 0| 2| 2| 2| 1| 2| 2| | | DAY ON TEST | 7| 7| 3| 9| 7| 7| 5| 7| 7| 7| 7| 0| 3| 7| 7| | | | 1| 4| 2| 7| 4| 4| 0| 4| 8| 4| 4| 7| 8| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 6250 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | Unilateral, Aspermia | X X X X | 4 | Unilateral, Cyst | 3 | 1 3.0| Unilateral, Inflammation, Chronic | | | Active | 3 2 | 2 2.5| |__________________________________________________________________________|____________| Preputial Gland | + | 1 | Cyst | 3 | 1 3.0| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | Cyst | 2 | 1 2.0| Unilateral, Cyst | 2 2 3 | 3 2.3| Unilateral, Germinal Epithelium, | | | Degeneration | 3 2 3 2 | 4 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + A M + + + + + | 13 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + M + A + + + + + + | 13 | Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M + + + + + M + + + + + + | 11 | |__________________________________________________________________________|____________| Spleen | + + A + + + + + A + + + + + + | 13 | Hematopoietic Cell Proliferation | 1 1 2 1 1 2 2 1 | 8 1.4| Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0| |__________________________________________________________________________|____________| Thymus | + + M + + + + + M + + M + + + | 12 | Atrophy, Diffuse | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 1| 2| 2| 1| 2| 0| 2| 2| 2| 1| 2| 2| | | DAY ON TEST | 7| 7| 3| 9| 7| 7| 5| 7| 7| 7| 7| 0| 3| 7| 7| | | | 1| 4| 2| 7| 4| 4| 0| 4| 8| 4| 4| 7| 8| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 6250 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + A + + + + + A + + + + + + | 13 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + A + + + + + + | 14 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + A + + + + + A + + + + + + | 13 | Dilatation, Diffuse | 1 | 1 1.0| Renal Tubule, Dilatation, Focal | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| | | | 1| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 12500 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 1 | 1 1.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + A + + | 14 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + A + + | 14 | |__________________________________________________________________________|____________| Tooth | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + A + + | 14 | Atrophy | 1 1 1 2 1 1 1 2 1 | 9 1.2| Hypertrophy, Focal | 1 1 1 1 1 1 | 6 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + A + + | 14 | |__________________________________________________________________________|____________| Pituitary Gland | + + I + + + I + + I + + M + + | 11 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + A + + | 14 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | Bilateral, Spermatozoa, Degeneration | 1 | 1 1.0| Unilateral, Aspermia | X X | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| | | | 1| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 12500 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + A + + | 14 | Cyst | 1 | 1 1.0| Bilateral, Germinal Epithelium, | | | Degeneration | 1 | 1 1.0| Unilateral, Cyst | 2 2 | 2 2.0| Unilateral, Germinal Epithelium, | | | Degeneration | 3 2 | 2 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M + + + + + + + + + + | 14 | Hyperplasia | 2 3 | 2 2.5| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + A + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M + + M M + I + + + + M | 10 | Hyperplasia | 4 | 1 4.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 4 3 | 2 3.5| Pigmentation | 1 1 2 1 2 1 1 1 1 1 1 1 | 12 1.2| |__________________________________________________________________________|____________| Thymus | + + + + M + + + + + + + A + + | 13 | Atrophy, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| | | | 1| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 12500 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + A + + | 14 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | Renal Tubule, Dilatation, Diffuse | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| | | DAY ON TEST | 9| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 3| | | | 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 1| 4| 4| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 25000 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | A + + + + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Salivary Glands | + + | 2 | |__________________________________________________________________________|____________| Stomach, Forestomach | A + + + + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Stomach, Glandular | A + + + + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Tooth | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | Atrophy | 1 2 1 1 1 2 2 2 | 8 1.5| Hypertrophy, Focal | 1 1 1 1 1 1 1 | 7 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | A + + M + + + + + + + + + + + | 13 | |__________________________________________________________________________|____________| Thyroid Gland | A + + + + + + + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | Unilateral, Aspermia | X X X | 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| | | DAY ON TEST | 9| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 3| | | | 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 1| 4| 4| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 25000 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Unilateral, Duct, Hyperplasia, | | | Regenerative | 2 | 1 2.0| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Seminal Vesicle | + | 1 | Dilatation | 4 | 1 4.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | Cyst | 2 | 1 2.0| Unilateral, Cyst | 2 2 | 2 2.0| Unilateral, Germinal Epithelium, | | | Degeneration | 3 1 3 | 3 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | A + + + + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | A + + + + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Spleen | A + + + + + + + + + + + + + + | 14 | Hematopoietic Cell Proliferation | 1 2 1 2 2 1 2 1 | 8 1.5| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 13 1.0| |__________________________________________________________________________|____________| Thymus | I + + + + + + + + + + + + + + | 14 | Atrophy, Diffuse | 3 4 3 2 | 4 3.0| Atrophy, Focal | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| | | DAY ON TEST | 9| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 3| | | | 6| 4| 4| 4| 4| 4| 4| 9| 4| 4| 4| 1| 4| 4| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 25000 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Skin | + | 1 | Control Epidermis, Hyperplasia, Focal| 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | A + + + + + + + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | A + + + + + + + + + + + + + + | 14 | Hemorrhage, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | A + + + + + + + + + + + + + + | 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 8| 7| 7| 7| 7| 4| 8| | | | 4| 4| 4| 4| 0| 4| 4| 1| 0| 4| 4| 4| 4| 1| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 50000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Gallbladder | M + M + + + + + + + + + + A + | 12 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Infiltration Cellular, Focal, | | | Lymphocyte | 1 | 1 1.0| Necrosis, Focal | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + A + | 14 | Inflammation, Acute | 1 | 1 1.0| |__________________________________________________________________________|____________| Tongue | + + + + + + + + + + M + + A + | 13 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 8| 7| 7| 7| 7| 4| 8| | | | 4| 4| 4| 4| 0| 4| 4| 1| 0| 4| 4| 4| 4| 1| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 50000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Tooth | + + + + + + | 6 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + I A + | 13 | Atrophy | 1 1 1 1 1 2 | 6 1.2| Hypertrophy, Focal | 1 1 1 1 1 | 5 1.0| Subcapsular, Hyperplasia, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + M A + | 13 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Parathyroid Gland | M + M M M + M + M M M M + A M | 4 | |__________________________________________________________________________|____________| Pituitary Gland | + + I + M + + + + + I + I A I | 9 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + A + | 14 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | + | 1 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | Bilateral, Spermatozoa, Degeneration | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 8| 7| 7| 7| 7| 4| 8| | | | 4| 4| 4| 4| 0| 4| 4| 1| 0| 4| 4| 4| 4| 1| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 50000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Unilateral, Aspermia | X X | 2 | Unilateral, Cyst | 2 | 1 2.0| Unilateral, Spermatozoa, Degeneration| 2 | 1 2.0| |__________________________________________________________________________|____________| Penis | + | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + M + + + + + + + M + + A + | 12 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | Bilateral, Germinal Epithelium, | | | Degeneration | 2 | 1 2.0| Unilateral, Cyst | 2 | 1 2.0| Unilateral, Germinal Epithelium, | | | Degeneration | 2 3 3 | 3 2.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + A + | 14 | Hyperplasia | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + A + | 14 | Hyperplasia, Plasma Cell | 3 | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + A M | 13 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + A + | 14 | Hematopoietic Cell Proliferation | 1 4 2 1 | 4 2.0| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 8| 7| 7| 7| 7| 4| 8| | | | 4| 4| 4| 4| 0| 4| 4| 1| 0| 4| 4| 4| 4| 1| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 50000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + M + + + + A M | 12 | Atrophy, Focal | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + | 15 | Cortex, Cerebrum, Degeneration, Focal| 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + M M + M I M M M M M M M M M | 2 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + A + | 14 | Alveolar Epithelium, Hyperplasia, | | | Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + A + | 14 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + A + | 14 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 99033-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03 Route: DOSED FEED Time: 11:28:56 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 7| 7| 7| 7| 0| 7| 7| 7| 8| 7| 7| 7| 7| 4| 8| | | | 4| 4| 4| 4| 0| 4| 4| 1| 0| 4| 4| 4| 4| 1| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 50000 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + A + | 14 | Retina, Atrophy | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | 14 3.0| |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Zymbal's Gland | + + + + + + + + + + + + + A + | 14 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | Nephropathy | 1 | 1 1.0| Renal Tubule, Cyst | X | 1 | Renal Tubule, Dilatation, Diffuse | 2 | 1 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + A + | 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------