TDMS Study 99033-02 Pathology Tables
NTP EXP/TEST: 99033-02 TRANSGENIC MODEL EVALUATION II (ASPARTAME) PAGE: 1
TEST TYPE: 26-39 WEEKS INITIAL AND CURRENT BODY WEIGHT DATE: 03/05/03
ROUTE: DOSED FEED TIME: 13:38:05
EIS REPORT 03
FINAL #3/P53 MICE
FACILITY: BIORELIANCE
NTP C#: C99033
CONTRACT NUMBER: N01-ES-65406
CAS NUMBER: 22839-47-0
ANIMAL SUPPLIER: TACONIC FARMS
CAGE RANGE: ALL
DATE RANGE: ALL
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP EXP/TEST: 99033-02 TRANSGENIC MODEL EVALUATION II (ASPARTAME) PAGE: 2
TEST TYPE: 26-39 WEEKS INITIAL AND CURRENT BODY WEIGHT DATE: 03/05/03
ROUTE: DOSED FEED EISRPT03 TIME: 13:38:05
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SPECIES-STRAIN: P53(C57BL/6)-MICE SEX: FEMALE WEEK ON DOSE: 40 FIRST DOSE: 10/14/99
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-----INITIAL----- ------------CURRENT------------- -----CHANGE------
TREATMENT N MEAN(G) SD N MEAN(G) SD % REL CNTRL N MEAN(G) SD
VEHICLE CONTROL 15 16.9 1.2 14 26.1 2.4 14 9.1 2.1
3125 PPM 15 16.4 1.6 14 24.3 1.9 93.1 14 7.9 1.5
6250 PPM 15 16.8 1.6 14 26.2 3.0 100.3 14 9.4 2.3
12500 PPM 15 16.3 1.1 15 25.4 3.0 97.3 15 9.1 2.6
25000 PPM 15 16.4 1.0 15 25.3 1.7 96.9 15 8.9 1.6
50000 PPM 15 16.1 1.2 15 25.1 2.5 96.1 15 9.0 2.9
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SPECIES-STRAIN: P53(C57BL/6)-MICE SEX: MALE WEEK ON DOSE: 40 FIRST DOSE: 10/14/99
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-----INITIAL----- ------------CURRENT------------- -----CHANGE------
TREATMENT N MEAN(G) SD N MEAN(G) SD % REL CNTRL N MEAN(G) SD
VEHICLE CONTROL 15 20.9 1.7 14 31.3 4.3 14 10.4 3.7
3125 PPM 15 20.3 1.6 15 30.3 3.1 96.8 15 10.0 2.8
6250 PPM 15 20.1 1.5 13 29.7 2.5 94.8 13 9.7 1.9
12500 PPM 15 20.1 1.7 15 29.8 3.5 95.2 15 9.7 3.1
25000 PPM 15 20.2 1.9 14 30.1 3.0 96.1 14 10.0 3.7
50000 PPM 15 20.2 1.4 14 29.9 3.2 95.5 14 9.7 2.4
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