TDMS Study 99033-02 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: BIORELIANCE TRANSGENIC MODEL EVALUATION II (ASPARTAME) DATE: 03/05/03
EXPERIMENT: 99033 TEST: 02 TIME: 13:37:05
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: 26-39 WEEKS ROUTE: DOSED FEED NTP: C99033
------------------------------------------------------------------------------------------------------------------------------------
FINAL #3/P53 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: BIORELIANCE TRANSGENIC MODEL EVALUATION II (ASPARTAME) DATE: 03/05/03
EXPERIMENT: 99033 TEST: 02 TIME: 13:46:34
TEST TYPE: 26 ROUTE: DOSED FEED NTP: C99033
CONT: N01-ES-65406 CAS: 22839-47-0
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==================================================================================================================================
VEHICLE CONTROL 3125 PPM 6250 PPM 12500 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
2 4.1 22.0 4.5 21.8 1.10 639 4.3 21.4 1.05 1242 4.0 20.9 0.98 2395
3 4.2 22.6 4.1 22.3 0.98 581 4.2 22.2 1.00 1195 4.0 21.6 0.95 2318
4 4.1 22.8 4.3 23.0 1.05 588 4.4 22.4 1.07 1218 4.1 22.5 1.00 2296
5 4.3 23.5 4.3 23.6 1.00 568 4.2 22.9 0.98 1151 4.1 22.9 0.95 2254
6 4.2 24.0 4.3 24.1 1.02 563 4.3 23.7 1.02 1130 3.9 23.4 0.93 2106
7 4.3 24.8 4.3 24.7 1.00 549 4.2 24.2 0.98 1074 4.0 23.9 0.93 2085
8 4.3 25.7 4.3 25.5 1.00 528 4.1 24.5 0.95 1045 4.1 24.6 0.95 2104
9 4.1 26.1 4.3 25.9 1.05 522 4.0 24.9 0.98 1013 3.9 24.9 0.95 1946
10 4.2 26.6 4.5 26.2 1.07 537 4.5 25.3 1.07 1120 3.9 25.6 0.93 1912
11 4.0 27.0 4.6 26.7 1.15 533 4.5 25.5 1.13 1110 4.1 26.0 1.03 1950
12 4.1 27.1 4.6 27.2 1.12 532 4.2 25.9 1.02 1014 4.3 26.5 1.05 2027
13 4.1 27.6 4.4 27.6 1.07 496 4.3 26.8 1.05 1010 4.0 26.8 0.98 1866
14 4.3 28.0 4.2 27.8 0.98 471 4.3 27.3 1.00 992 4.1 27.3 0.95 1864
15 4.2 28.3 4.4 28.2 1.05 492 4.5 27.4 1.07 1026 4.0 27.5 0.95 1814
16 4.4 28.6 4.4 28.4 1.00 480 4.0 27.0 0.91 931 4.1 28.1 0.93 1839
17 4.4 29.1 4.5 28.8 1.02 493 4.4 27.8 1.00 983 4.2 28.2 0.95 1869
18 4.3 29.4 4.5 29.2 1.05 480 4.2 28.7 0.98 924 4.4 28.9 1.02 1892
19 4.3 29.8 4.3 29.4 1.00 452 4.1 29.0 0.95 884 3.9 28.9 0.91 1692
20 4.2 30.1 4.1 29.3 0.98 441 4.1 29.1 0.98 875 3.8 28.8 0.90 1647
21 4.1 30.3 4.2 29.6 1.02 449 4.2 29.7 1.02 885 3.9 29.3 0.95 1671
22 4.0 30.0 4.3 29.5 1.08 455 4.1 29.5 1.03 861 4.1 29.6 1.03 1731
23 4.1 30.8 4.3 29.0 1.05 459 4.2 29.8 1.02 876 3.7 29.0 0.90 1596
24 4.1 30.6 4.3 29.6 1.05 451 4.2 29.8 1.02 883 3.7 29.0 0.90 1578
25 3.9 30.4 4.3 29.6 1.10 457 4.2 29.8 1.08 873 4.0 29.2 1.03 1693
26 4.1 30.9 4.4 30.0 1.07 453 4.2 29.7 1.02 873 4.0 29.5 0.98 1688
27 4.0 30.8 4.1 29.8 1.03 435 4.1 30.0 1.03 851 4.0 29.6 1.00 1694
28 4.3 31.0 4.2 29.9 0.98 435 4.0 29.9 0.93 829 3.9 29.7 0.91 1653
29 4.2 31.2 4.2 30.2 1.00 438 4.1 29.9 0.98 847 4.0 29.8 0.95 1673
30 4.5 31.8 4.4 30.6 0.98 454 4.3 29.8 0.96 896 4.2 30.2 0.93 1746
31 4.4 32.3 4.4 31.0 1.00 445 4.3 30.3 0.98 884 4.2 30.0 0.95 1752
32 4.5 32.6 4.3 31.0 0.96 434 4.3 30.6 0.96 868 4.1 29.9 0.91 1723
33 4.3 32.4 4.3 30.9 1.00 437 4.3 30.3 1.00 879 4.2 29.8 0.98 1745
34 4.3 32.3 4.3 30.6 1.00 443 4.5 30.5 1.05 917 4.1 29.9 0.95 1710
35 4.6 32.2 4.5 30.7 0.98 453 4.2 30.2 0.91 868 4.5 29.7 0.98 1907
36 4.4 32.4 4.4 30.9 1.00 445 4.2 30.1 0.95 875 4.2 29.9 0.95 1754
37 4.2 31.6 4.4 30.6 1.05 445 4.3 30.1 1.02 897 4.2 29.7 1.00 1761
38 4.3 31.9 4.4 30.9 1.02 447 4.4 30.1 1.02 905 4.1 29.3 0.95 1746
39 4.1 31.9 4.2 30.4 1.02 432 4.4 29.6 1.07 922 3.9 29.4 0.95 1653
40 4.2 31.3 4.3 30.3 1.02 448 4.3 29.7 1.02 911 4.5 29.8 1.07 1872
1 TO 13 WEEKS
----------------
MEAN 4.2 25.0 4.4 24.9 1.05 553 4.3 24.1 1.02 1110 4.0 24.1 0.97 2105
SD(D) 0.1 0.1 0.05 38 0.2 0.05 81 0.1 0.04 175
CV(E) 2.3 3.1 5.1 6.8 3.6 5.0 7.3 2.9 4.0 8.3
14 TO 52 WEEKS
----------------
MEAN 4.2 30.8 4.3 29.9 1.02 453 4.2 29.5 1.00 897 4.1 29.3 0.96 1739
SD(D) 0.2 0.1 0.04 17 0.1 0.05 45 0.2 0.04 89
CV(E) 4.0 2.5 3.5 3.7 3.2 4.6 5.0 5.0 4.5 5.1
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
=============================================================================
25000 PPM 50000 PPM
--------------------------------- ---------------------------------
DOSE/ DOSE/
GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
=============================================================================
2 4.2 21.5 1.02 4832 3.9 21.4 0.95 9070
3 4.1 21.8 0.98 4696 3.7 21.6 0.88 8475
4 4.2 22.8 1.02 4655 3.8 22.5 0.93 8556
5 4.3 23.3 1.00 4593 4.0 23.0 0.93 8662
6 4.1 23.9 0.98 4241 4.0 23.3 0.95 8474
7 4.1 24.6 0.95 4187 4.0 24.1 0.93 8223
8 4.1 24.7 0.95 4120 4.1 24.5 0.95 8320
9 4.2 25.4 1.02 4160 3.8 24.8 0.93 7634
10 4.4 26.1 1.05 4268 4.0 25.5 0.95 7810
11 4.1 26.6 1.03 3859 4.0 25.8 1.00 7796
12 4.7 27.3 1.15 4266 4.5 26.5 1.10 8551
13 4.3 27.3 1.05 3914 4.1 27.0 1.00 7562
14 4.3 28.1 1.00 3865 4.1 27.5 0.95 7453
15 4.1 28.1 0.98 3652 3.9 27.5 0.93 7061
16 4.4 28.4 1.00 3887 4.2 27.8 0.95 7460
17 4.5 29.0 1.02 3842 4.1 28.1 0.93 7288
18 4.4 29.3 1.02 3713 4.3 28.7 1.00 7453
19 4.1 29.4 0.95 3460 4.1 29.2 0.95 6937
20 4.3 30.2 1.02 3559 3.9 29.5 0.93 6627
21 4.2 30.4 1.02 3441 3.8 29.5 0.93 6350
22 3.9 30.0 0.98 3240 3.8 29.0 0.95 6538
23 3.9 29.9 0.95 3272 3.8 29.1 0.93 6500
24 4.0 29.7 0.98 3404 3.8 29.1 0.93 6520
25 3.8 29.2 0.97 3275 3.7 29.1 0.95 6276
26 4.3 29.5 1.05 3658 4.0 29.3 0.98 6747
27 4.0 29.6 1.00 3395 3.9 29.4 0.98 6667
28 3.9 28.8 0.91 3357 3.9 29.7 0.91 6523
29 4.1 29.0 0.98 3508 3.9 29.7 0.93 6613
30 4.2 29.3 0.93 3578 4.1 29.7 0.91 6861
31 4.2 29.4 0.95 3578 4.2 30.2 0.95 6970
32 4.2 29.5 0.93 3541 4.0 30.3 0.89 6571
33 4.3 29.7 1.00 3644 4.1 30.5 0.95 6674
34 4.6 30.3 1.07 3811 4.0 30.2 0.93 6611
35 4.3 30.1 0.93 3541 4.2 30.2 0.91 6964
36 4.3 30.1 0.98 3533 4.1 30.1 0.93 6869
37 4.0 29.7 0.95 3383 4.0 30.1 0.95 6654
38 4.3 29.9 1.00 3583 4.2 30.0 0.98 6971
39 4.4 30.1 1.07 3642 4.1 29.9 1.00 6798
40 4.3 30.1 1.02 3526 4.1 29.9 0.98 6790
1 TO 13 WEEKS
----------------
MEAN 4.2 24.6 1.02 4316 4.0 24.2 0.96 8261
SD(D) 0.2 0.05 311 0.2 0.05 465
CV(E) 4.2 5.2 7.2 5.3 5.7 5.6
14 TO 52 WEEKS
----------------
MEAN 4.2 29.5 0.99 3551 4.0 29.4 0.94 6805
SD(D) 0.2 0.04 177 0.2 0.03 323
CV(E) 4.7 4.3 5.0 3.9 2.9 4.7
=============================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==================================================================================================================================
VEHICLE CONTROL 3125 PPM 6250 PPM 12500 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
2 3.9 18.5 4.1 18.1 1.05 706 4.0 18.2 1.03 1378 4.2 18.1 1.08 2898
3 4.4 19.6 4.3 19.2 0.98 695 4.0 18.9 0.91 1313 4.1 18.7 0.93 2724
4 4.7 20.0 4.8 20.2 1.02 737 4.5 19.9 0.96 1407 4.7 19.9 1.00 2938
5 4.9 20.8 4.7 20.5 0.96 714 4.7 20.5 0.96 1444 4.8 20.3 0.98 2991
6 4.8 21.0 4.7 20.5 0.98 722 4.8 21.2 1.00 1404 4.6 20.6 0.96 2798
7 5.2 20.7 4.7 20.7 0.90 707 4.8 20.5 0.92 1465 4.9 20.6 0.94 2950
8 5.0 21.5 4.5 20.9 0.90 676 5.0 21.4 1.00 1451 4.8 21.3 0.96 2827
9 4.8 21.7 4.7 21.5 0.98 689 5.0 22.0 1.04 1414 5.0 21.4 1.04 2934
10 5.3 22.1 5.0 21.8 0.94 714 4.9 22.0 0.92 1380 4.8 22.2 0.91 2699
11 5.6 22.1 4.8 22.0 0.86 687 5.3 22.4 0.95 1474 5.1 22.3 0.91 2830
12 5.1 22.0 4.8 22.0 0.94 682 4.4 22.6 0.86 1222 5.1 22.5 1.00 2828
13 5.1 22.2 4.9 22.6 0.96 683 4.7 23.4 0.92 1261 4.7 22.5 0.92 2635
14 4.5 22.6 4.4 23.0 0.98 592 4.2 23.5 0.93 1106 4.5 22.9 1.00 2448
15 4.3 22.9 4.6 23.2 1.07 621 4.3 23.9 1.00 1134 4.2 22.9 0.98 2267
16 4.7 22.7 5.0 23.3 1.06 670 4.4 24.0 0.94 1146 5.1 23.3 1.09 2735
17 4.9 23.1 4.8 23.4 0.98 640 4.9 24.0 1.00 1272 4.7 23.6 0.96 2493
18 4.9 23.3 4.8 23.4 0.98 640 4.5 24.4 0.92 1153 5.6 24.4 1.14 2852
19 4.6 23.6 4.5 23.5 0.98 598 4.3 24.8 0.93 1074 4.8 24.6 1.04 2440
20 4.6 23.7 4.3 23.8 0.93 569 4.2 24.8 0.91 1051 4.5 25.1 0.98 2227
21 4.0 23.7 4.2 23.5 1.05 563 4.3 25.1 1.08 1080 4.4 25.1 1.10 2195
22 4.9 24.1 4.4 23.7 0.90 584 4.6 25.0 0.94 1139 4.9 25.1 1.00 2436
23 4.8 24.0 4.7 23.4 0.98 623 4.7 25.3 0.98 1164 4.3 24.9 0.90 2165
24 4.8 24.2 4.7 23.8 0.98 613 4.5 25.5 0.94 1112 4.5 24.7 0.94 2295
25 4.8 24.2 4.7 23.6 0.98 617 4.6 25.4 0.96 1120 4.7 24.7 0.98 2382
26 4.5 24.3 4.6 23.7 1.02 607 4.8 25.7 1.07 1156 4.8 25.1 1.07 2418
27 4.7 23.9 4.3 23.4 0.91 579 4.5 25.7 0.96 1090 4.4 25.1 0.94 2218
28 4.9 24.5 4.4 23.4 0.90 590 4.6 25.8 0.94 1109 4.8 25.1 0.98 2376
29 4.6 24.2 4.6 23.4 1.00 616 4.7 25.8 1.02 1144 4.7 25.1 1.02 2340
30 4.7 25.0 4.5 24.1 0.96 579 4.5 25.5 0.96 1102 4.6 25.8 0.98 2238
31 4.4 25.2 4.3 24.1 0.98 555 4.4 25.7 1.00 1068 4.4 26.0 1.00 2115
32 4.4 25.3 4.4 24.4 1.00 559 4.3 25.8 0.98 1033 4.4 25.8 1.00 2141
33 4.7 24.9 4.4 24.0 0.94 572 4.5 25.8 0.96 1093 4.7 25.9 1.00 2252
34 4.6 25.2 4.6 24.5 1.00 589 4.3 25.9 0.93 1032 4.4 25.9 0.96 2133
35 4.8 25.2 4.5 24.7 0.94 564 6.8 25.8 1.42 1650 5.3 25.8 1.10 2572
36 4.6 25.4 4.5 24.7 0.98 569 4.7 26.4 1.02 1117 4.4 26.0 0.96 2131
37 4.7 25.3 4.5 24.6 0.96 567 4.5 26.3 0.96 1074 4.8 26.0 1.02 2291
38 4.9 25.7 4.5 24.4 0.92 580 4.8 26.6 0.98 1135 4.9 26.0 1.00 2336
39 4.4 25.7 4.6 24.4 1.05 585 4.5 26.5 1.02 1066 4.4 25.8 1.00 2134
40 4.7 26.1 4.5 24.3 0.96 580 4.6 26.2 0.98 1086 4.6 25.4 0.98 2252
1 TO 13 WEEKS
----------------
MEAN 4.9 21.0 4.7 20.8 0.96 701 4.7 21.1 0.96 1384 4.7 20.9 0.97 2838
SD(D) 0.4 0.3 0.05 19 0.4 0.05 80 0.3 0.05 111
CV(E) 8.6 5.6 5.5 2.7 8.2 5.5 5.8 6.7 5.5 3.9
14 TO 52 WEEKS
----------------
MEAN 4.6 24.4 4.5 23.8 0.98 593 4.6 25.4 0.99 1130 4.7 25.0 1.00 2329
SD(D) 0.2 0.2 0.05 29 0.5 0.10 115 0.3 0.06 182
CV(E) 4.6 3.8 4.7 4.8 10.6 9.6 10.2 6.6 5.6 7.8
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
=============================================================================
25000 PPM 50000 PPM
--------------------------------- ---------------------------------
DOSE/ DOSE/
GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
=============================================================================
2 4.1 18.2 1.05 5686 3.8 17.7 0.97 10687
3 4.2 19.0 0.95 5551 4.0 18.6 0.91 10601
4 4.4 20.1 0.94 5428 4.0 19.3 0.85 10387
5 4.5 20.1 0.92 5589 4.2 19.9 0.86 10482
6 4.4 20.6 0.92 5344 4.3 20.3 0.90 10630
7 4.7 20.8 0.90 5670 4.6 19.9 0.88 11459
8 4.5 21.0 0.90 5347 4.5 21.3 0.90 10536
9 4.9 21.7 1.02 5581 4.3 21.3 0.90 9994
10 4.9 21.7 0.92 5648 3.9 21.9 0.74 8969
11 5.1 22.2 0.91 5702 4.6 21.8 0.82 10565
12 4.6 22.3 0.90 5157 4.8 21.9 0.94 10939
13 4.8 22.5 0.94 5349 4.6 22.3 0.90 10385
14 4.6 22.9 1.02 5026 4.3 22.6 0.96 9436
15 5.1 23.6 1.19 5416 4.6 22.9 1.07 10064
16 4.7 23.4 1.00 4989 5.0 23.1 1.06 10709
17 4.7 22.9 0.96 5080 4.0 23.0 0.82 8713
18 4.8 23.3 0.98 5140 4.8 23.5 0.98 10290
19 4.6 23.6 1.00 4891 4.6 23.6 1.00 9754
20 4.4 23.8 0.96 4643 4.5 24.1 0.98 9340
21 4.3 24.0 1.08 4473 4.3 24.3 1.08 8764
22 4.5 23.7 0.92 4702 4.3 24.0 0.88 8868
23 4.7 23.7 0.98 4915 4.1 23.6 0.85 8710
24 4.5 23.8 0.94 4686 4.6 24.2 0.96 9482
25 4.6 23.5 0.96 4888 4.4 24.1 0.92 9102
26 4.8 24.3 1.07 4956 4.5 24.4 1.00 9152
27 4.4 24.0 0.94 4540 4.5 24.2 0.96 9354
28 4.6 23.9 0.94 4761 4.5 24.3 0.92 9267
29 4.5 24.0 0.98 4676 4.3 24.4 0.93 8775
30 4.7 24.2 1.00 4851 4.2 24.3 0.89 8690
31 4.6 24.5 1.05 4712 4.3 24.7 0.98 8720
32 4.2 24.3 0.95 4273 4.5 24.6 1.02 9187
33 4.7 24.5 1.00 4795 4.6 25.0 0.98 9121
34 4.5 24.9 0.98 4525 4.5 24.6 0.98 9199
35 5.1 24.9 1.06 5113 4.6 24.5 0.96 9396
36 4.5 25.1 0.98 4444 4.3 24.9 0.93 8708
37 4.6 25.0 0.98 4578 4.3 24.8 0.91 8746
38 4.8 25.4 0.98 4719 4.5 25.1 0.92 9009
39 4.9 25.4 1.11 4844 4.5 25.0 1.02 8939
40 4.7 25.3 1.00 4617 4.7 25.1 1.00 9338
1 TO 13 WEEKS
----------------
MEAN 4.6 20.9 0.94 5504 4.3 20.5 0.88 10469
SD(D) 0.3 0.05 175 0.3 0.06 587
CV(E) 6.2 5.1 3.2 7.7 6.9 5.6
14 TO 52 WEEKS
----------------
MEAN 4.6 24.2 1.00 4787 4.5 24.2 0.96 9216
SD(D) 0.2 0.06 250 0.2 0.06 510
CV(E) 4.7 6.0 5.2 4.7 6.5 5.5
=============================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==================================================================================================================================
VEHICLE CONTROL 3125 PPM 6250 PPM 12500 PPM 25000 PPM
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
===================================================================================================================================
B 20.9 15 20.3 15 20.1 15 20.1 15 20.2 15
1 20.9 15 20.3 15 20.1 15 20.1 15 20.2 15
2 4.1 2520 22.0 15 4.5 2490 21.8 15 4.3 2490 21.4 15 4.0 2505 20.9 15 4.2 2505 21.5 15
3 4.2 2520 22.6 15 4.1 2520 22.3 15 4.2 2520 22.2 15 4.0 2535 21.6 15 4.1 2532 21.8 15
4 4.1 2535 22.8 15 4.3 2535 23.0 15 4.4 2535 22.4 15 4.1 2520 22.5 15 4.2 2520 22.8 15
5 4.3 2520 23.5 15 4.3 2520 23.6 15 4.2 2520 22.9 15 4.1 2535 22.9 15 4.3 2505 23.3 15
6 4.2 2505 24.0 15 4.3 2535 24.1 15 4.3 2535 23.7 15 3.9 2521 23.4 15 4.1 2520 23.9 15
7 4.3 2540 24.8 15 4.3 2520 24.7 15 4.2 2520 24.2 15 4.0 2534 23.9 15 4.1 2520 24.6 15
8 4.3 2520 25.7 15 4.3 2520 25.5 15 4.1 2520 24.5 15 4.1 2506 24.6 15 4.1 2352 24.7 14
9 4.1 2517 26.1 15 4.3 2510 25.9 15 4.0 2508 24.9 15 3.9 2503 24.9 15 4.2 2338 25.4 14
10 4.2 2505 26.6 15 4.5 2491 26.2 15 4.5 2488 25.3 15 3.9 2476 25.6 15 4.4 2317 26.1 14
11 4.0 2527 27.0 15 4.6 2535 26.7 15 4.5 2550 25.5 15 4.1 2565 26.0 15 4.1 2380 26.6 14
12 4.1 2513 27.1 15 4.6 2505 27.2 15 4.2 2490 25.9 15 4.3 2490 26.5 15 4.7 2324 27.3 14
13 4.1 2535 27.6 15 4.4 2535 27.6 15 4.3 2540 26.8 15 4.0 2565 26.8 15 4.3 2380 27.3 14
14 4.3 2520 28.0 15 4.2 2520 27.8 15 4.3 2520 27.3 15 4.1 2520 27.3 15 4.3 2352 28.1 14
15 4.2 2520 28.3 15 4.4 2520 28.2 15 4.5 2520 27.4 15 4.0 2520 27.5 15 4.1 2352 28.1 14
16 4.4 2394 28.6 14 4.4 2520 28.4 15 4.0 2520 27.0 15 4.1 2505 28.1 15 4.4 2352 28.4 14
17 4.4 2310 29.1 14 4.5 2520 28.8 15 4.4 2520 27.8 15 4.2 2535 28.2 15 4.5 2352 29.0 14
18 4.3 2394 29.4 14 4.5 2505 29.2 15 4.2 2338 28.7 14 4.4 2490 28.9 15 4.4 2338 29.3 14
19 4.3 2310 29.8 14 4.3 2535 29.4 15 4.1 2366 29.0 14 3.9 2544 28.9 15 4.1 2366 29.4 14
20 4.2 2338 30.1 14 4.1 2505 29.3 15 4.1 2338 29.1 14 3.8 2520 28.8 15 4.3 2348 30.2 14
21 4.1 2352 30.3 14 4.2 2520 29.6 15 4.2 2352 29.7 14 3.9 2505 29.3 15 4.2 2342 30.4 14
22 4.0 3360 30.0 14 4.3 2520 29.5 15 4.1 2352 29.5 14 4.1 2520 29.6 15 3.9 2352 30.0 14
23 4.1 1358 30.8 14 4.3 2535 29.0 15 4.2 2366 29.8 14 3.7 2520 29.0 15 3.9 2363 29.9 14
24 4.1 2362 30.6 14 4.3 2535 29.6 15 4.2 2366 29.8 14 3.7 2550 29.0 15 4.0 2380 29.7 14
25 3.9 2338 30.4 14 4.3 2505 29.6 15 4.2 2338 29.8 14 4.0 2505 29.2 15 3.8 2338 29.2 14
26 4.1 2352 30.9 14 4.4 2511 30.0 15 4.2 2338 29.7 14 4.0 2505 29.5 15 4.3 2336 29.5 14
27 4.0 2394 30.8 14 4.1 2550 29.8 15 4.1 2352 30.0 14 4.0 2483 29.6 15 4.0 2352 29.6 14
28 4.3 2352 31.0 14 4.2 2535 29.9 15 4.0 2352 29.9 14 3.9 2520 29.7 15 3.9 2366 28.8 14
29 4.2 2366 31.2 14 4.2 2535 30.2 15 4.1 2366 29.9 14 4.0 2535 29.8 15 4.1 2358 29.0 14
30 4.5 2296 31.8 14 4.4 2460 30.6 15 4.3 2366 29.8 14 4.2 2535 30.2 15 4.2 2366 29.3 14
31 4.4 2352 32.3 14 4.4 2520 31.0 15 4.3 2145 30.3 13 4.2 2520 30.0 15 4.2 2310 29.4 14
32 4.5 2352 32.6 14 4.3 2520 31.0 15 4.3 2184 30.6 13 4.1 2535 29.9 15 4.2 2366 29.5 14
33 4.3 2352 32.4 14 4.3 2520 30.9 15 4.3 2184 30.3 13 4.2 2505 29.8 15 4.3 2352 29.7 14
34 4.3 2352 32.3 14 4.3 2520 30.6 15 4.5 2184 30.5 13 4.1 2535 29.9 15 4.6 2352 30.3 14
35 4.6 2366 32.2 14 4.5 2535 30.7 15 4.2 2197 30.2 13 4.5 2535 29.7 15 4.3 2380 30.1 14
36 4.4 2338 32.4 14 4.4 2505 30.9 15 4.2 2171 30.1 13 4.2 2490 29.9 15 4.3 2324 30.1 14
37 4.2 2366 31.6 14 4.4 2531 30.6 15 4.3 2197 30.1 13 4.2 2535 29.7 15 4.0 2366 29.7 14
38 4.3 2352 31.9 14 4.4 2520 30.9 15 4.4 2171 30.1 13 4.1 2505 29.3 15 4.3 2326 29.9 14
39 4.1 2366 31.9 14 4.2 2535 30.4 15 4.4 2197 29.6 13 3.9 2535 29.4 15 4.4 2366 30.1 14
40 4.2 2338 31.3 14 4.3 2508 30.3 15 4.3 2165 29.7 13 4.5 2479 29.8 15 4.3 2327 30.1 14
MEAN BODY WGT FOR WEEKS
1 TO 13 24.7 24.5 23.8 23.8 24.3
14 TO 52 30.8 29.9 29.5 29.3 29.5
==================================================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==============================
50000 PPM
----------------------
DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS
===============================
B 20.2 15
1 20.2 15
2 3.9 2505 21.4 15
3 3.7 2520 21.6 15
4 3.8 2520 22.5 15
5 4.0 2520 23.0 15
6 4.0 2520 23.3 15
7 4.0 2535 24.1 15
8 4.1 2505 24.5 15
9 3.8 2505 24.8 15
10 4.0 2460 25.5 15
11 4.0 2402 25.8 14
12 4.5 2145 26.5 13
13 4.1 2559 27.0 14
14 4.1 2352 27.5 14
15 3.9 2338 27.5 14
16 4.2 2352 27.8 14
17 4.1 2366 28.1 14
18 4.3 2324 28.7 14
19 4.1 2380 29.2 14
20 3.9 2352 29.5 14
21 3.8 2338 29.5 14
22 3.8 2352 29.0 14
23 3.8 2352 29.1 14
24 3.8 2380 29.1 14
25 3.7 2338 29.1 14
26 4.0 2352 29.3 14
27 3.9 2310 29.4 14
28 3.9 2352 29.7 14
29 3.9 2366 29.7 14
30 4.1 2380 29.7 14
31 4.2 2338 30.2 14
32 4.0 2366 30.3 14
33 4.1 2352 30.5 14
34 4.0 2366 30.2 14
35 4.2 2374 30.2 14
36 4.1 2330 30.1 14
37 4.0 2366 30.1 14
38 4.2 2338 30.0 14
39 4.1 2357 29.9 14
40 4.1 2306 29.9 14
MEAN BODY WGT FOR WEEKS
1 TO 13 23.9
14 TO 52 29.4
==============================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==================================================================================================================================
VEHICLE CONTROL 3125 PPM 6250 PPM 12500 PPM 25000 PPM
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
===================================================================================================================================
B 16.9 15 16.4 15 16.8 15 16.3 15 16.4 15
1 16.9 15 16.4 15 16.8 15 16.3 15 16.4 15
2 3.9 2520 18.5 15 4.1 2490 18.1 15 4.0 2502 18.2 15 4.2 2505 18.1 15 4.1 2505 18.2 15
3 4.4 2520 19.6 15 4.3 2520 19.2 15 4.0 2520 18.9 15 4.1 2535 18.7 15 4.2 2520 19.0 15
4 4.7 2535 20.0 15 4.8 2535 20.2 15 4.5 2535 19.9 15 4.7 2520 19.9 15 4.4 2520 20.1 15
5 4.9 2520 20.8 15 4.7 2520 20.5 15 4.7 2520 20.5 15 4.8 2535 20.3 15 4.5 2505 20.1 15
6 4.8 2505 21.0 15 4.7 2535 20.5 15 4.8 2535 21.2 15 4.6 2520 20.6 15 4.4 2520 20.6 15
7 5.2 2378 20.7 14 4.7 2520 20.7 15 4.8 2520 20.5 15 4.9 2535 20.6 15 4.7 2534 20.8 15
8 5.0 2352 21.5 14 4.5 2520 20.9 15 5.0 2520 21.4 15 4.8 2505 21.3 15 4.5 2492 21.0 15
9 4.8 2352 21.7 14 4.7 2505 21.5 15 5.0 2505 22.0 15 5.0 2505 21.4 15 4.9 2505 21.7 15
10 5.3 2338 22.1 13 5.0 2490 21.8 15 4.9 2490 22.0 15 4.8 2471 22.2 15 4.9 2475 21.7 15
11 5.6 2366 22.1 14 4.8 2550 22.0 15 5.3 2550 22.4 15 5.1 2565 22.3 15 5.1 2565 22.2 15
12 5.1 2338 22.0 14 4.8 2499 22.0 15 4.4 2490 22.6 15 5.1 2475 22.5 15 4.6 2490 22.3 15
13 5.1 2366 22.2 14 4.9 2536 22.6 15 4.7 2550 23.4 15 4.7 2565 22.5 15 4.8 2550 22.5 15
14 4.5 2352 22.6 14 4.4 2520 23.0 15 4.2 2520 23.5 15 4.5 2520 22.9 15 4.6 2520 22.9 15
15 4.3 2352 22.9 14 4.6 2352 23.2 14 4.3 2520 23.9 15 4.2 2520 22.9 15 5.1 2520 23.6 15
16 4.7 2394 22.7 14 5.0 2352 23.3 14 4.4 2520 24.0 15 5.1 2505 23.3 15 4.7 2520 23.4 15
17 4.9 2310 23.1 14 4.8 2352 23.4 14 4.9 2520 24.0 15 4.7 2535 23.6 15 4.7 2520 22.9 15
18 4.9 2394 23.3 14 4.8 2338 23.4 14 4.5 2505 24.4 15 5.6 2490 24.4 15 4.8 2505 23.3 15
19 4.6 2310 23.6 14 4.5 2366 23.5 14 4.3 2535 24.8 15 4.8 2550 24.6 15 4.6 2535 23.6 15
20 4.6 2338 23.7 14 4.3 2338 23.8 14 4.2 2505 24.8 15 4.5 2520 25.1 15 4.4 2520 23.8 15
21 4.0 2352 23.7 14 4.2 2352 23.5 14 4.3 2520 25.1 15 4.4 2505 25.1 15 4.3 2505 24.0 15
22 4.9 2352 24.1 14 4.4 2352 23.7 14 4.6 2520 25.0 15 4.9 2520 25.1 15 4.5 2520 23.7 15
23 4.8 2366 24.0 14 4.7 2366 23.4 14 4.7 2535 25.3 15 4.3 2520 24.9 15 4.7 2526 23.7 15
24 4.8 2366 24.2 14 4.7 2366 23.8 14 4.5 2536 25.5 15 4.5 2550 24.7 15 4.5 2551 23.8 15
25 4.8 2338 24.2 14 4.7 2338 23.6 14 4.6 2338 25.4 14 4.7 2505 24.7 15 4.6 2504 23.5 15
26 4.5 2352 24.3 14 4.6 2338 23.7 14 4.8 2338 25.7 14 4.8 2518 25.1 15 4.8 2496 24.3 15
27 4.7 2394 23.9 14 4.3 2380 23.4 14 4.5 2352 25.7 14 4.4 2475 25.1 15 4.4 2520 24.0 15
28 4.9 2352 24.5 14 4.4 2366 23.4 14 4.6 2352 25.8 14 4.8 2520 25.1 15 4.6 2535 23.9 15
29 4.6 2365 24.2 14 4.6 2365 23.4 14 4.7 2366 25.8 14 4.7 2535 25.1 15 4.5 2526 24.0 15
30 4.7 2296 25.0 14 4.5 2302 24.1 14 4.5 2366 25.5 14 4.6 2535 25.8 15 4.7 2535 24.2 15
31 4.4 2352 25.2 14 4.3 2345 24.1 14 4.4 2310 25.7 14 4.4 2520 26.0 15 4.6 2475 24.5 15
32 4.4 2352 25.3 14 4.4 2352 24.4 14 4.3 2352 25.8 14 4.4 2535 25.8 15 4.2 2535 24.3 15
33 4.7 2352 24.9 14 4.4 2352 24.0 14 4.5 2352 25.8 14 4.7 2505 25.9 15 4.7 2507 24.5 15
34 4.6 2352 25.2 14 4.6 2352 24.5 14 4.3 2352 25.9 14 4.4 2535 25.9 15 4.5 2520 24.9 15
35 4.8 2366 25.2 14 4.5 2366 24.7 14 6.8 2371 25.8 14 5.3 2535 25.8 15 5.1 2380 24.9 15
36 4.6 2338 25.4 14 4.5 2338 24.7 14 4.7 2167 26.4 14 4.4 2490 26.0 15 4.5 2490 25.1 15
37 4.7 2366 25.3 14 4.5 2352 24.6 14 4.5 2366 26.3 14 4.8 2535 26.0 15 4.6 2535 25.0 15
38 4.9 2352 25.7 14 4.5 2352 24.4 14 4.8 2338 26.6 14 4.9 2505 26.0 15 4.8 2490 25.4 15
39 4.4 2366 25.7 14 4.6 2366 24.4 14 4.5 2366 26.5 14 4.4 2535 25.8 15 4.9 2535 25.4 15
40 4.7 2352 26.1 14 4.5 2352 24.3 14 4.6 2352 26.2 14 4.6 2520 25.4 15 4.7 2520 25.3 15
MEAN BODY WGT FOR WEEKS
1 TO 13 20.7 20.5 20.8 20.5 20.5
14 TO 52 24.4 23.8 25.4 25.0 24.2
==================================================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==============================
50000 PPM
----------------------
DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS
===============================
B 16.1 15
1 16.1 15
2 3.8 2505 17.7 15
3 4.0 2520 18.6 15
4 4.0 2520 19.3 15
5 4.2 2520 19.9 15
6 4.3 2520 20.3 15
7 4.6 2535 19.9 15
8 4.5 2505 21.3 15
9 4.3 2505 21.3 15
10 3.9 2460 21.9 15
11 4.6 2580 21.8 15
12 4.8 2460 21.9 15
13 4.6 2580 22.3 15
14 4.3 2520 22.6 15
15 4.6 2505 22.9 15
16 5.0 2520 23.1 15
17 4.0 2535 23.0 15
18 4.8 2490 23.5 15
19 4.6 2550 23.6 15
20 4.5 2520 24.1 15
21 4.3 2505 24.3 15
22 4.3 2520 24.0 15
23 4.1 2520 23.6 15
24 4.6 2550 24.2 15
25 4.4 2505 24.1 15
26 4.5 2520 24.4 15
27 4.5 2475 24.2 15
28 4.5 2520 24.3 15
29 4.3 2535 24.4 15
30 4.2 2550 24.3 15
31 4.3 2505 24.7 15
32 4.5 2535 24.6 15
33 4.6 2520 25.0 15
34 4.5 2535 24.6 15
35 4.6 2550 24.5 15
36 4.3 2490 24.9 15
37 4.3 2535 24.8 15
38 4.5 2505 25.1 15
39 4.5 2521 25.0 15
40 4.7 2520 25.1 15
MEAN BODY WGT FOR WEEKS
1 TO 13 20.2
14 TO 52 24.2
==============================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.