TDMS Study 99033-02 Pathology Tables
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02 Route: DOSED FEED Time: 11:51:08 FINAL/MICE Facility: BIORELIANCE Chemical CAS #: 22839-47-0 Lock Date: 07/20/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02 Route: DOSED FEED Time: 11:51:08 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000 CONTROL PPM PPM PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 15 15 15 15 15 15 Early Deaths Moribund Sacrifice 1 1 Natural Death 1 Survivors Terminal Sacrifice 14 14 14 15 15 15 Animals Examined Microscopically 15 15 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (14) (15) Lymphoma Malignant 1 (7%) Intestine Large, Cecum (15) (1) (15) Lymphoid Tissue, Lymphoma Malignant 1 (100%) Liver (15) (15) (15) (15) (15) (15) Lymphoma Malignant 1 (7%) Sarcoma 1 (7%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Pituitary Gland (9) (14) (13) (14) (11) (14) Pars Distalis, Adenoma 1 (11%) Thyroid Gland (14) (13) (14) (14) (13) (15) Follicular Cell, Adenoma 1 (8%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02 Route: DOSED FEED Time: 11:51:08 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000 CONTROL PPM PPM PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) Pancreatic, Lymphoma Malignant 1 (100%) Renal, Lymphoma Malignant 1 (100%) Lymph Node, Mandibular (15) (13) (13) (15) (15) (14) Lymphoma Malignant 1 (7%) Lymph Node, Mesenteric (15) (14) (14) (14) (15) (15) Sarcoma 1 (7%) Lymph Node, Mediastinal (12) (13) (13) (12) (13) (15) Lymphoma Malignant 1 (8%) Spleen (15) (15) (15) (15) (15) (15) Lymphoma Malignant 1 (7%) 1 (7%) Thymus (14) (14) (14) (15) (15) (15) Lymphoma Malignant 1 (7%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (13) (14) (14) (15) (12) (15) Carcinoma 1 (8%) 1 (7%) Skin (15) (1) (15) Subcutaneous Tissue, Fibrosarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (15) (1) (15) Femur, Osteosarcoma 1 (7%) 1 (7%) Vertebra, Osteosarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02 Route: DOSED FEED Time: 11:51:08 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000 CONTROL PPM PPM PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (14) (15) (15) (15) Lymphoma Malignant 1 (7%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (14) (15) (15) (15) (15) Lymphoma Malignant 1 (7%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15) Lymphoma Malignant 1 (7%) 1 (7%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 4 NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02 Route: DOSED FEED Time: 11:51:08 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000 CONTROL PPM PPM PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 4 2 2 1 1 Total Primary Neoplasms 4 2 3 2 1 Total Animals with Benign Neoplasms 1 1 Total Benign Neoplasms 1 1 Total Animals with Malignant Neoplasms 3 2 2 1 1 Total Malignant Neoplasms 3 2 3 1 1 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 5 NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02 Route: DOSED FEED Time: 11:51:08 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000 CONTROL PPM PPM PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 15 15 15 15 15 15 Early Deaths Natural Death 1 1 1 Moribund Sacrifice 1 1 Survivors Terminal Sacrifice 14 15 13 15 14 14 Animals Examined Microscopically 15 15 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Small, Duodenum (14) (15) Polyp Adenomatous 1 (7%) Liver (14) (15) (15) (15) (14) (15) Lymphoma Malignant 2 (13%) Salivary Glands (14) (1) (1) (1) (15) Lymphoma Malignant 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Prostate (14) (15) (15) (15) (14) (15) Sarcoma 1 (7%) ____________________________________________________________________________________________________________________________________ Page 6 NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02 Route: DOSED FEED Time: 11:51:08 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000 CONTROL PPM PPM PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (14) (15) (14) (15) (14) (15) Lymphoma Malignant 1 (7%) Lymph Node, Mesenteric (14) (14) (15) (13) (14) (15) Lymphoma Malignant 1 (7%) Lymph Node, Mediastinal (13) (14) (14) (13) (12) (13) Lymphoma Malignant 2 (14%) Spleen (14) (15) (15) (15) (14) (15) Lymphoma Malignant 2 (13%) Thymus (14) (15) (15) (14) (15) (14) Lymphoma Malignant 2 (13%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (15) (15) Subcutaneous Tissue, Sarcoma 1 (7%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) (14) (15) Lymphoma Malignant 2 (13%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02 Route: DOSED FEED Time: 11:51:08 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000 CONTROL PPM PPM PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (14) (15) (15) (15) (14) (15) Lymphoma Malignant 1 (7%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15) Lymphoma Malignant 2 (13%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 8 NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02 Route: DOSED FEED Time: 11:51:08 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000 CONTROL PPM PPM PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 2 1 2 Total Primary Neoplasms 2 1 2 Total Animals with Benign Neoplasms 1 Total Benign Neoplasms 1 Total Animals with Malignant Neoplasms 2 1 1 Total Malignant Neoplasms 2 1 1 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 9 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------