TDMS Study 99033-02 Pathology Tables
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:34:32
FINAL #3/P53 MICE
Facility: BIORELIANCE
Chemical CAS #: 22839-47-0
Lock Date: 07/20/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:34:32
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Moribund Sacrifice 1 1
Natural Death 1
Survivors
Terminal Sacrifice 14 14 14 15 15 15
Animals Examined Microscopically 15 15 15 15 15 15
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ALIMENTARY SYSTEM
Gallbladder (14) (15)
Intestine Large, Cecum (15) (1) (15)
Liver (15) (15) (15) (15) (15) (15)
Sarcoma 1 (7%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Pituitary Gland (9) (14) (13) (14) (11) (14)
Pars Distalis, Adenoma 1 (11%)
Thyroid Gland (14) (13) (14) (14) (13) (15)
Follicular Cell, Adenoma 1 (8%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:34:32
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Lymph Node, Mandibular (15) (13) (13) (15) (15) (14)
Lymph Node, Mesenteric (15) (14) (14) (14) (15) (15)
Sarcoma 1 (7%)
Lymph Node, Mediastinal (12) (13) (13) (12) (13) (15)
Spleen (15) (15) (15) (15) (15) (15)
Thymus (14) (14) (14) (15) (15) (15)
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INTEGUMENTARY SYSTEM
Mammary Gland (13) (14) (14) (15) (12) (15)
Carcinoma 1 (8%) 1 (7%)
Skin (15) (1) (15)
Subcutaneous Tissue, Fibrosarcoma 1 (100%)
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MUSCULOSKELETAL SYSTEM
Bone (15) (1) (15)
Femur, Osteosarcoma 1 (7%) 1 (7%)
Vertebra, Osteosarcoma 1 (100%)
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (15) (15) (14) (15) (15) (15)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:34:32
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (14) (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Lymphoma Malignant 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:34:32
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 4 2 2 1 1
Total Primary Neoplasms 4 2 3 2 1
Total Animals with Benign Neoplasms 1 1
Total Benign Neoplasms 1 1
Total Animals with Malignant Neoplasms 3 2 2 1 1
Total Malignant Neoplasms 3 2 3 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:34:32
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Natural Death 1 1 1
Moribund Sacrifice 1 1
Survivors
Terminal Sacrifice 14 15 13 15 14 14
Animals Examined Microscopically 15 15 15 15 15 15
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ALIMENTARY SYSTEM
Intestine Small, Duodenum (14) (15)
Polyp Adenomatous 1 (7%)
Liver (15) (15) (15) (15) (14) (15)
Salivary Glands (15) (1) (1) (1) (15)
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CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Prostate (14) (15) (15) (15) (14) (15)
Sarcoma 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:34:32
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (14) (15) (14) (15) (14) (15)
Lymph Node, Mesenteric (14) (14) (15) (13) (14) (15)
Lymph Node, Mediastinal (13) (14) (14) (13) (12) (13)
Spleen (15) (15) (15) (15) (14) (15)
Thymus (14) (15) (15) (14) (15) (14)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15)
Subcutaneous Tissue, Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (14) (15)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (14) (15) (15) (15) (14) (15)
Page 7
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:34:32
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Lymphoma Malignant 2 (13%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ASPARTAME) Date: 03/05/03
Route: DOSED FEED Time: 11:34:32
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 2 1 3
Total Primary Neoplasms 2 1 3
Total Animals with Benign Neoplasms 1
Total Benign Neoplasms 1
Total Animals with Malignant Neoplasms 2 1 2
Total Malignant Neoplasms 2 1 2
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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