TDMS Study 99033-03 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BIORELIANCE TRANSGENIC MODEL EVALUATION II (ASPARTAME) DATE: 03/05/03
EXPERIMENT: 99033 TEST: 03 TIME: 11:17:56
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK ROUTE: DOSED FEED NTP: C99033B
------------------------------------------------------------------------------------------------------------------------------------
FINAL #3 TG:P16 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BIORELIANCE TRANSGENIC MODEL EVALUATION II (ASPARTAME) DATE: 03/05/03
EXPERIMENT: 99033 TEST: 03 TIME: 11:25:53
SPECIES: MICE, TG:P16-INK4A
TEST TYPE: SUBCHRONIC (26-WEEK) ROUTE: DOSED FEED NTP: 99033B
CONT: N01-ES-65406 CAS: 22839-47-0
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==========================================================================================================================
WEEK VEHICLE CONTROL 3125 PPM 6250 PPM 12500 PPM 25000 PPM
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
B 22.2 15 22.1 99.5 15 22.2 100.0 15 22.0 99.1 15 21.8 98.2 15
1 22.2 15 22.1 99.5 15 22.2 100.0 15 22.0 99.1 15 21.8 98.2 15
2 22.4 15 22.2 99.1 15 22.4 100.0 15 22.1 98.7 15 22.0 98.2 15
3 23.1 15 23.2 100.4 15 23.0 99.6 15 22.9 99.1 15 22.7 98.3 15
4 23.6 15 23.8 100.8 15 23.4 99.2 15 23.8 100.8 15 23.0 97.5 14
5 25.0 15 24.9 99.6 15 24.6 98.4 15 24.8 99.2 15 24.7 98.8 14
6 25.6 15 25.5 99.6 15 25.1 98.0 15 25.2 98.4 15 25.0 97.7 14
7 26.1 15 26.5 101.5 15 26.2 100.4 15 25.6 98.1 15 26.1 100.0 14
8 26.7 15 26.7 100.0 15 26.3 98.5 15 26.7 100.0 14 26.6 99.6 14
9 27.4 15 27.7 101.1 15 26.5 96.7 15 27.2 99.3 14 27.1 98.9 14
10 28.6 14 27.9 97.6 15 27.1 94.8 15 27.6 96.5 14 27.7 96.9 14
11 28.9 14 27.9 96.5 15 27.9 96.5 15 28.2 97.6 14 28.0 96.9 14
12 29.4 14 28.4 96.6 15 28.2 95.9 15 28.3 96.3 14 28.2 95.9 14
13 30.0 14 28.8 96.0 15 28.3 94.3 15 29.0 96.7 14 29.1 97.0 14
14 30.1 14 29.1 96.7 15 28.7 95.3 15 29.6 98.3 14 29.1 96.7 14
15 30.8 14 29.4 95.5 15 29.8 96.8 15 29.9 97.1 14 29.5 95.8 14
16 30.6 14 29.8 97.4 15 29.8 97.4 15 30.7 100.3 14 29.8 97.4 14
17 31.6 14 30.7 97.2 15 30.8 97.5 15 31.7 100.3 14 30.5 96.5 14
18 32.4 14 31.1 96.0 15 30.5 94.1 15 32.1 99.1 14 31.6 97.5 14
19 32.8 14 31.5 96.0 15 30.1 91.8 15 32.4 98.8 14 32.0 97.6 14
20 33.3 14 32.1 96.4 15 30.9 92.8 15 32.8 98.5 14 32.2 96.7 14
21 34.0 14 32.6 95.9 15 31.9 93.8 15 33.1 97.4 14 33.0 97.1 14
22 34.2 14 32.7 95.6 15 32.2 94.2 15 32.7 95.6 14 33.1 96.8 14
23 34.4 14 32.7 95.1 15 32.2 93.6 15 33.0 95.9 14 33.0 95.9 14
24 34.5 14 32.7 94.8 15 32.2 93.3 15 33.3 96.5 14 33.0 95.7 14
25 34.6 14 32.8 94.8 15 32.2 93.1 15 33.2 96.0 14 32.9 95.1 14
26 34.6 14 32.7 94.5 15 32.2 93.1 15 33.6 97.1 14 33.1 95.7 14
27 34.6 14 32.7 94.5 15 32.6 94.2 15 33.8 97.7 14 33.3 96.2 14
28 35.1 14 33.4 95.2 15 32.9 93.7 15 34.3 97.7 14 33.9 96.6 14
29 35.6 14 33.9 95.2 15 33.3 93.5 15 34.6 97.2 14 34.3 96.3 14
30 35.9 14 33.8 94.2 15 33.8 94.2 15 35.0 97.5 14 34.6 96.4 14
31 35.8 14 33.4 93.3 15 33.9 94.7 15 34.8 97.2 14 34.5 96.4 14
32 36.1 14 33.5 92.8 15 33.7 93.4 15 34.8 96.4 14 34.6 95.8 14
33 35.6 14 33.5 94.1 15 34.0 95.5 15 34.3 96.3 14 34.6 97.2 14
34 36.1 14 33.1 91.7 15 34.2 94.7 15 34.9 96.7 14 35.1 97.2 14
35 35.4 14 33.0 93.2 14 33.9 95.8 15 35.3 99.7 14 34.8 98.3 14
36 35.6 14 33.6 94.4 14 34.3 96.3 15 35.5 99.7 14 35.3 99.2 14
37 35.6 14 33.1 93.0 14 34.1 95.8 15 35.1 98.6 14 34.9 98.0 14
38 35.9 14 32.6 90.8 14 34.0 94.7 15 35.2 98.1 14 35.0 97.5 14
39 35.6 14 32.4 91.0 14 33.9 95.2 15 34.9 98.0 14 35.4 99.4 14
40 35.7 14 33.1 92.7 14 33.7 94.4 15 35.0 98.0 14 35.6 99.7 14
TERM. SAC. 14 14 15 14 14
==========================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
===============================
50000 PPM
WEEK ----------------
AV.WT. PERCENT NO.
(GRAMS) OF CNTL (A)
==============================
B 21.9 98.6 15
1 21.9 98.6 15
2 22.3 99.6 15
3 23.0 99.6 15
4 23.6 100.0 15
5 24.9 99.6 15
6 25.1 98.0 15
7 26.4 101.1 15
8 26.5 99.3 15
9 26.9 98.2 15
10 27.3 95.5 15
11 28.1 97.2 15
12 28.9 98.3 15
13 29.2 97.3 15
14 29.4 97.7 15
15 29.9 97.1 15
16 30.4 99.3 15
17 31.4 99.4 15
18 31.6 97.5 15
19 32.1 97.9 15
20 32.7 98.2 15
21 32.8 96.5 15
22 33.1 96.8 15
23 33.0 95.9 15
24 33.4 96.8 15
25 33.3 96.2 15
26 33.5 96.8 15
27 33.7 97.4 15
28 33.8 96.3 15
29 33.9 95.2 15
30 34.3 95.5 15
31 34.4 96.1 15
32 34.0 94.2 15
33 33.9 95.2 15
34 34.4 95.3 15
35 34.3 96.9 15
36 34.3 96.3 15
37 33.9 95.2 15
38 34.1 95.0 15
39 34.4 96.6 15
40 34.2 95.8 15
TERM. SAC. 15
===============================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==========================================================================================================================
WEEK VEHICLE CONTROL 3125 PPM 6250 PPM 12500 PPM 25000 PPM
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
B 17.9 15 18.4 102.8 15 18.3 102.2 15 18.2 101.7 15 17.9 100.0 15
1 17.9 15 18.4 102.8 15 18.3 102.2 15 18.2 101.7 15 17.9 100.0 15
2 18.7 15 19.0 101.6 15 18.4 98.4 15 18.6 99.5 15 18.6 99.5 15
3 19.8 14 20.3 102.5 15 19.8 100.0 15 20.0 101.0 15 19.6 99.0 15
4 20.7 14 21.0 101.4 15 20.6 99.5 15 20.8 100.5 15 20.3 98.1 15
5 21.2 14 21.6 101.9 15 21.9 103.3 15 21.4 100.9 15 20.9 98.6 15
6 22.1 14 22.3 100.9 15 22.4 101.4 15 22.3 100.9 15 21.8 98.6 15
7 22.5 14 23.0 102.2 15 22.6 100.4 15 22.8 101.3 15 22.3 99.1 15
8 21.8 14 22.3 102.3 15 22.6 103.7 15 22.9 105.0 15 22.0 100.9 15
9 22.7 14 23.1 101.8 15 23.0 101.3 15 23.0 101.3 15 22.1 97.4 15
10 23.1 14 23.4 101.3 15 22.8 98.7 15 23.7 102.6 15 22.8 98.7 15
11 23.0 14 23.6 102.6 15 23.7 103.0 15 23.9 103.9 15 22.9 99.6 15
12 23.3 14 24.1 103.4 15 24.0 103.0 15 24.7 106.0 15 23.1 99.1 15
13 23.5 14 24.5 104.3 15 23.8 101.3 15 25.0 106.4 15 23.8 101.3 15
14 23.3 14 24.2 103.9 15 24.0 103.0 15 24.6 105.6 15 23.3 100.0 15
15 24.3 14 25.0 102.9 15 25.1 103.3 15 25.1 103.3 15 23.8 97.9 15
16 24.3 14 24.9 102.5 15 25.1 103.3 15 25.3 104.1 15 23.7 97.5 15
17 24.4 14 25.7 105.3 15 26.1 107.0 14 25.8 105.7 15 24.2 99.2 15
18 24.8 14 25.8 104.0 15 26.1 105.2 14 25.8 104.0 15 24.9 100.4 15
19 25.1 14 26.3 104.8 15 26.1 104.0 14 26.2 104.4 15 25.1 100.0 15
20 25.3 14 26.7 105.5 15 25.5 100.8 14 26.3 104.0 15 25.1 99.2 15
21 25.7 14 27.2 105.8 15 26.1 101.6 14 26.9 104.7 15 25.6 99.6 15
22 25.4 14 27.0 106.3 15 26.7 105.1 14 26.8 105.5 15 25.4 100.0 15
23 25.3 14 26.8 105.9 15 26.7 105.5 14 26.6 105.1 15 25.7 101.6 15
24 25.7 14 27.2 105.8 15 26.9 104.7 14 26.5 103.1 15 25.4 98.8 15
25 25.9 14 27.4 105.8 15 26.4 101.9 14 26.7 103.1 15 25.3 97.7 15
26 26.2 14 27.3 104.2 15 26.7 101.9 14 26.8 102.3 15 25.4 96.9 15
27 25.6 14 26.9 105.1 15 26.5 103.5 14 27.0 105.5 15 25.6 100.0 15
28 26.2 14 27.9 106.5 15 27.4 104.6 14 27.4 104.6 15 25.9 98.9 15
29 26.8 14 28.1 104.9 15 27.0 100.7 14 27.6 103.0 15 26.1 97.4 15
30 26.4 14 28.5 108.0 15 27.2 103.0 14 27.8 105.3 15 26.4 100.0 15
31 25.6 14 28.2 110.2 15 28.3 110.5 14 27.7 108.2 15 26.3 102.7 15
32 26.2 14 28.1 107.3 15 27.8 106.1 13 27.7 105.7 15 26.7 101.9 15
33 26.8 13 28.0 104.5 15 28.1 104.9 13 27.5 102.6 15 26.5 98.9 15
34 27.1 13 28.4 104.8 15 28.3 104.4 13 27.7 102.2 15 26.9 99.3 15
35 27.0 13 28.0 103.7 15 27.9 103.3 13 28.0 103.7 15 26.9 99.6 15
36 27.0 13 28.1 104.1 15 28.1 104.1 13 28.0 103.7 15 26.4 97.8 15
37 26.8 13 27.6 103.0 15 27.7 103.4 13 27.8 103.7 15 26.8 100.0 15
38 26.9 13 27.7 103.0 15 28.0 104.1 13 27.8 103.3 15 26.6 98.9 15
39 26.7 13 27.6 103.4 15 28.3 106.0 13 28.2 105.6 15 27.1 101.5 15
40 27.4 13 27.9 101.8 15 28.8 105.1 13 28.6 104.4 15 26.9 98.2 15
TERM. SAC. 13 15 13 15 15
==========================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
===============================
50000 PPM
WEEK ----------------
AV.WT. PERCENT NO.
(GRAMS) OF CNTL (A)
==============================
B 18.2 101.7 15
1 18.2 101.7 15
2 18.8 100.5 15
3 20.0 101.0 15
4 20.7 100.0 15
5 21.9 103.3 15
6 22.5 101.8 15
7 22.6 100.4 15
8 22.5 103.2 15
9 22.8 100.4 15
10 23.1 100.0 15
11 23.6 102.6 15
12 23.9 102.6 15
13 23.9 101.7 15
14 24.2 103.9 15
15 24.8 102.1 15
16 24.5 100.8 15
17 25.6 104.9 15
18 25.7 103.6 15
19 25.8 102.8 15
20 26.0 102.8 15
21 26.5 103.1 15
22 26.5 104.3 15
23 26.7 105.5 15
24 26.6 103.5 15
25 26.2 101.2 15
26 26.2 100.0 15
27 26.7 104.3 15
28 26.9 102.7 15
29 26.7 99.6 15
30 27.1 102.7 15
31 27.5 107.4 15
32 27.4 104.6 15
33 27.6 103.0 15
34 28.1 103.7 15
35 27.8 103.0 15
36 28.0 103.7 15
37 27.7 103.4 15
38 27.7 103.0 15
39 27.8 104.1 15
40 28.3 103.3 14
TERM. SAC. 14
===============================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.