TDMS Study 99039-01 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BIORELIANCE TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) DATE: 10/01/02
EXPERIMENT: 99039 TEST: 01 TIME: 07:53:49
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: 26-39 WEEKS ROUTE: DOSED FEED NTP: C99039
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BIORELIANCE TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) DATE: 10/01/02
EXPERIMENT: 99039 TEST: 01 TIME: 7:59:20
SPECIES: MICE, TG.AC HEMI
TEST TYPE: 26 ROUTE: DOSED FEED NTP: C99039
CONT: NO1-ES-75408 CAS: 55589-62-3
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM)
===================================================================================================================================
WEEK VEHICLE CONTROL POSITIVECONTROL 0.3% 1.0 % 3.0 %
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
B 21.2 15 20.7 97.6 15 21.2 100.0 15 21.3 100.5 15 21.3 100.5 15
1 21.2 15 20.7 97.6 15 21.2 100.0 15 21.3 100.5 15 21.3 100.5 15
2 22.6 15 21.9 96.9 14 22.0 97.3 15 22.7 100.4 15 22.5 99.6 15
3 23.3 15 22.1 94.8 14 23.6 101.3 15 23.7 101.7 15 23.7 101.7 15
4 24.2 15 23.4 96.7 14 24.9 102.9 15 24.8 102.5 15 24.7 102.1 15
5 24.9 15 24.6 98.8 14 25.7 103.2 15 25.3 101.6 15 25.1 100.8 15
6 25.5 15 24.1 94.5 14 26.3 103.1 15 26.4 103.5 15 25.6 100.4 15
7 26.3 15 23.6 89.7 14 26.5 100.8 15 26.8 101.9 15 26.9 102.3 15
8 25.9 15 24.0 92.7 14 27.2 105.0 15 27.5 106.2 15 27.4 105.8 15
9 27.4 15 25.5 93.1 14 27.6 100.7 15 27.7 101.1 15 27.7 101.1 15
10 27.5 15 26.0 94.5 14 27.6 100.4 15 28.0 101.8 15 27.7 100.7 15
11 27.0 15 26.4 97.8 14 28.2 104.4 14 28.4 105.2 15 27.6 102.2 15
12 28.0 15 26.7 95.4 10 29.0 103.6 14 29.2 104.3 15 28.8 102.9 15
13 28.2 15 26.0 92.2 6 28.9 102.5 14 29.4 104.3 15 29.0 102.8 15
14 28.8 15 24.9 86.5 1 29.8 103.5 14 29.7 103.1 15 29.3 101.7 15
15 29.3 15 29.9 102.0 14 30.0 102.4 15 29.9 102.0 15
16 29.5 15 29.8 101.0 14 30.3 102.7 15 30.1 102.0 15
17 29.6 15 29.8 100.7 14 30.5 103.0 15 30.4 102.7 15
18 29.2 15 30.5 104.5 14 30.7 105.1 15 30.6 104.8 15
19 29.4 15 30.4 103.4 14 30.5 103.7 15 30.7 104.4 15
20 29.5 15 29.7 100.7 14 30.5 103.4 15 30.6 103.7 15
21 29.5 15 30.1 102.0 14 31.2 105.8 15 31.1 105.4 15
22 29.5 15 30.9 104.7 14 31.6 107.1 15 31.5 106.8 15
23 30.4 14 32.0 105.3 13 31.4 103.3 15 31.8 104.6 15
24 31.5 13 31.1 98.7 13 31.8 101.0 15 31.9 101.3 15
25 31.6 13 32.2 101.9 13 32.2 101.9 15 32.1 101.6 15
26 31.8 13 32.2 101.3 13 32.2 101.3 15 32.8 103.1 14
27 32.0 13 32.2 100.6 13 32.2 100.6 15 32.3 100.9 14
28 32.0 13 32.6 101.9 13 32.9 102.8 15 32.8 102.5 14
29 32.4 13 32.8 101.2 13 33.1 102.2 14 32.5 100.3 14
30 32.5 13 33.3 102.5 13 33.4 102.8 14 33.0 101.5 14
31 32.5 13 33.3 102.5 13 33.1 101.8 14 33.0 101.5 14
32 32.5 13 33.2 102.2 13 33.6 103.4 14 33.7 103.7 14
33 32.3 13 32.5 100.6 13 33.2 102.8 14 33.0 102.2 14
34 32.2 13 32.7 101.6 13 33.4 103.7 14 33.4 103.7 14
35 32.6 13 32.8 100.6 12 33.4 102.5 14 33.4 102.5 14
36 33.0 13 32.7 99.1 12 33.7 102.1 14 33.4 101.2 14
37 32.7 13 33.5 102.4 12 34.1 104.3 14 33.3 101.8 14
38 32.9 13 33.5 101.8 12 33.4 101.5 14 33.2 100.9 14
39 33.2 13 32.9 99.1 12 34.4 103.6 13 33.9 102.1 14
40 33.2 13 33.6 101.2 11 34.1 102.7 13 33.5 100.9 14
TERM. SAC. 13 0 11 13 14
===================================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM)
===================================================================================================================================
WEEK VEHICLE CONTROL POSITIVECONTROL 0.3 % 1.0% 3.0%
---------------- ---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
==================================================================================================================================
B 17.9 15 17.7 98.9 15 17.8 99.4 15 18.0 100.6 15 17.8 99.4 15
1 17.9 15 17.7 98.9 15 17.8 99.4 15 18.0 100.6 15 17.8 99.4 15
2 17.5 15 18.2 104.0 15 18.2 104.0 15 18.2 104.0 15 18.1 103.4 15
3 17.8 15 18.6 104.5 15 18.5 103.9 15 18.3 102.8 15 18.3 102.8 15
4 19.6 15 20.2 103.1 15 19.5 99.5 15 19.3 98.5 15 19.7 100.5 15
5 19.7 15 20.3 103.0 15 19.6 99.5 15 19.8 100.5 15 19.7 100.0 15
6 19.7 15 20.9 106.1 15 19.5 99.0 15 19.6 99.5 15 19.4 98.5 15
7 20.3 15 20.5 101.0 15 20.1 99.0 15 20.5 101.0 15 20.6 101.5 15
8 20.7 15 21.3 102.9 15 20.8 100.5 15 21.2 102.4 15 20.8 100.5 15
9 21.3 15 21.3 100.0 15 21.6 101.4 15 21.5 100.9 15 21.2 99.5 15
10 21.7 15 21.7 100.0 15 21.6 99.5 15 21.9 100.9 15 21.4 98.6 15
11 22.1 15 22.2 100.5 15 21.9 99.1 15 22.2 100.5 15 22.3 100.9 15
12 22.5 15 21.1 93.8 9 22.1 98.2 14 22.6 100.4 15 21.9 97.3 15
13 22.2 15 22.5 101.4 5 22.4 100.9 14 22.7 102.3 15 21.9 98.6 15
14 22.3 15 22.0 98.7 3 22.7 101.8 14 22.7 101.8 15 22.1 99.1 15
15 22.5 15 24.7 109.8 3 23.1 102.7 14 22.9 101.8 15 22.6 100.4 15
16 23.5 15 24.6 104.7 2 23.3 99.1 14 23.2 98.7 15 23.4 99.6 15
17 23.7 15 23.6 99.6 14 23.2 97.9 15 23.0 97.0 15
18 24.0 15 23.4 97.5 14 23.7 98.8 15 23.3 97.1 15
19 23.8 15 23.3 97.9 14 23.9 100.4 15 23.3 97.9 15
20 24.4 15 23.5 96.3 14 23.9 98.0 15 23.7 97.1 15
21 24.6 15 23.8 96.7 14 24.4 99.2 15 23.5 95.5 15
22 24.9 15 24.0 96.4 14 24.6 98.8 15 23.3 93.6 15
23 25.0 15 24.1 96.4 14 24.2 96.8 15 24.0 96.0 15
24 25.4 15 24.5 96.5 14 24.8 97.6 15 24.7 97.2 14
25 25.3 15 24.5 96.8 14 24.7 97.6 15 25.1 99.2 14
26 25.4 15 24.8 97.6 14 25.0 98.4 15 25.2 99.2 14
27 26.7 15 25.3 94.8 14 25.2 94.4 15 25.1 94.0 14
28 26.5 15 25.5 96.2 14 25.1 94.7 15 25.1 94.7 14
29 26.8 15 25.2 94.0 13 25.1 93.7 15 24.8 92.5 14
30 27.1 15 25.6 94.5 13 25.4 93.7 15 25.7 94.8 14
31 26.7 15 25.5 95.5 13 25.5 95.5 14 26.1 97.8 14
32 26.4 15 25.7 97.3 13 26.0 98.5 14 26.1 98.9 14
33 25.9 14 25.8 99.6 13 25.5 98.5 14 25.8 99.6 14
34 26.0 14 26.1 100.4 13 25.4 97.7 14 25.6 98.5 14
35 26.0 13 24.9 95.8 13 25.9 99.6 13 26.4 101.5 13
36 28.3 12 25.9 91.5 13 26.3 92.9 13 26.2 92.6 13
37 28.4 12 26.4 93.0 13 26.6 93.7 13 26.3 92.6 13
38 27.8 12 26.7 96.0 12 26.6 95.7 13 26.6 95.7 12
39 28.5 12 26.6 93.3 12 26.8 94.0 13 26.7 93.7 12
40 28.5 12 26.3 92.3 12 27.0 94.7 12 26.6 93.3 12
TERM. SAC. 12 0 12 12 12
===================================================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.