TDMS Study 99039-01 Pathology Tables
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
FINAL#3/TG.AC MICE
Facility: BIORELIANCE
Chemical CAS #: 55589-62-3
Lock Date: 07/20/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 001 VEHICLE CONTROL
Include 002 0.3%
Include 003 1.0 %
Include 004 3.0 %
Include 006 VEHICLE CONTROL
Include 007 0.3 %
Include 008 1.0%
Include 009 3.0%
Note: Animals arranged according to days on test
Page 1
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 2| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 6| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
CONTROL | 9| 7| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | A + + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Gallbladder | A A + + + + + + + + M + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | A A + + + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | A A + + + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A A + + + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A A + + + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A + + + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Mesentery | + + | 2 |
|__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Salivary Glands | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + + + + + + | 14 |
Squamous Cell Papilloma | X X X X X X X | 7 |
Squamous Cell Papilloma, Multiple | X X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | A A + + + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 15 |
Squamous Cell Carcinoma, Metastatic, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 2| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 6| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
CONTROL | 9| 7| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Uncertain Primary Site | X | 1 |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
Odontogenic Tumor | X X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + M + + + + + M M + + | 12 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | A + + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Adrenal Medulla | A + + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M A + M M + + M + + M M M M M | 5 |
|__________________________________________________________________________|____________|
Pituitary Gland | + I + + + + + I I + + + + + + | 12 |
|__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | M A + + + + + M I + + M + M + | 9 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 2| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 6| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
CONTROL | 9| 7| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Ovary | A + + + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Uterus | A A + + + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Vagina | A A + + + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | A + + + M + + + M + + + + + + | 12 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A A + + + + M + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thymus | A A + + + + + M + M + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | A A + + + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Squamous Cell Papilloma | X | 1 |
Vulva, Squamous Cell Papilloma | X X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 2| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 6| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
CONTROL | 9| 7| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + A + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | A + M I I + I + I M I I I I M | 3 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolar/Bronchiolar Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Nose | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Pleura | + | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + I + + + | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | A A + + + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + M + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + M + M + + + + + + + + M + M | 11 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Urinary Bladder | A A + + + + + + + + + + + + + | 13 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 9| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 7| 6| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| | A |
0.3 % | 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 9| 1| 1| 2| 3| 4| 5| 6| 7| 8| 0| 2| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + | 1 |
|__________________________________________________________________________|____________|
Gallbladder | A | |
|__________________________________________________________________________|____________|
Intestine Large, Colon | A | |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | A | |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A | |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A | |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A | |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A | |
|__________________________________________________________________________|____________|
Liver | + + | 2 |
|__________________________________________________________________________|____________|
Pancreas | + | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | A A + + + + + + + + + | 9 |
Squamous Cell Papilloma | X X X X X X | 6 |
Squamous Cell Papilloma, Multiple | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | A | |
|__________________________________________________________________________|____________|
Tongue | + | 1 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 9| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 7| 6| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| | A |
0.3 % | 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 9| 1| 1| 2| 3| 4| 5| 6| 7| 8| 0| 2| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | A | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M | |
|__________________________________________________________________________|____________|
Pituitary Gland | M | |
|__________________________________________________________________________|____________|
Thyroid Gland | A | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
|__________________________________________________________________________|____________|
Ovary | A A + | 1 |
|__________________________________________________________________________|____________|
Uterus | A + + | 2 |
|__________________________________________________________________________|____________|
Vagina | A | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 9| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 7| 6| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| | A |
0.3 % | 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 9| 1| 1| 2| 3| 4| 5| 6| 7| 8| 0| 2| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A | |
|__________________________________________________________________________|____________|
Spleen | A | |
|__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
Squamous Cell Papilloma | X X | 2 |
Vulva, Squamous Cell Papilloma | X X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + | 2 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 9| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 7| 6| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 0| 1| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| | A |
0.3 % | 0| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 9| 1| 1| 2| 3| 4| 5| 6| 7| 8| 0| 2| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lung | A | |
|__________________________________________________________________________|____________|
Nose | + | 1 |
|__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | A | |
|__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | A A | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + | 14 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 7| 2| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 1| 3| 6| 7| 8| 9| 0| 2| 4| 5| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
Squamous Cell Papilloma | X X X X X X X X X | 9 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + | 6 |
Odontogenic Tumor | X X X X X X | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Uterus | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + | 6 |
Squamous Cell Papilloma | X X X | 3 |
Lip, Squamous Cell Papilloma | X X | 2 |
Vulva, Squamous Cell Papilloma | X X | 2 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 7| 2| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0% | 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 1| 3| 6| 7| 8| 9| 0| 2| 4| 5| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
|__________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 5| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 6| 2| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
3.0% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 4| 1| 9| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Gallbladder | + + A + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + + + + + + + + + + + | 14 |
Squamous Cell Papilloma | X X X X X X X X | 8 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
Odontogenic Tumor | X X X | 3 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 5| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 6| 2| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
3.0% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 4| 1| 9| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + + M M + M M M M + + | 6 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + I + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + M I + + + + | 12 |
|__________________________________________________________________________|____________|
Ovary | + + A + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Uterus | + + A + + + + + + + + + + + + | 14 |
Sarcoma Stromal | X | 1 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 5| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 6| 2| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
3.0% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 4| 1| 9| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Squamous Cell Papilloma | X | 1 |
Vulva, Squamous Cell Papilloma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + I + I + I + + + I + + + + + | 11 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 5| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 6| 2| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
3.0% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L |
| 4| 1| 9| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolar/Bronchiolar Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + + | 2 |
|__________________________________________________________________________|____________|
Eye | + + A + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + M + + + + M M I M + + + | 10 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 15 |
Transitional Epithelium, Papilloma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 8| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
CONTROL | 2| 6| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + M + | 14 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + M + M + + I + + + M | 11 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Mesentery | + + | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Squamous Cell Papilloma | X X X X X | 5 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 8| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
CONTROL | 2| 6| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Odontogenic Tumor | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | M + + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + M | 14 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + M | 14 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + M M I M M + M M M M | 3 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M I + + + + | 13 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Penis | + | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 8| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
CONTROL | 2| 6| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Preputial Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Squamous Cell Papilloma | X | 1 |
Dermis, Mast Cell Tumor Benign | X | 1 |
Lip, Squamous Cell Papilloma | X X | 2 |
Prepuce, Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 8| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
VEHICLE | 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
CONTROL | 2| 6| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Bone | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | I + + + + + + + + + + + + M + | 13 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolar/Bronchiolar Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Zymbal's Gland | M + + + + + + M M M M M I + M | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 1| 8| 3| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.3% | 3| 2| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| | L |
| 0| 2| 1| 3| 6| 7| 8| 9| 0| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 6 |
Squamous Cell Papilloma | X X X X | 4 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
Odontogenic Tumor | X X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Penis | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + | 7 |
Squamous Cell Papilloma | X | 1 |
Lip, Squamous Cell Papilloma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 0| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 1| 8| 3| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.3% | 3| 2| 2| 2| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| | L |
| 0| 2| 1| 3| 6| 7| 8| 9| 0| 4| 5| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolar/Bronchiolar Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 9| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1.0 % | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 5| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 3 |
Squamous Cell Papilloma | X X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + | 8 |
Squamous Cell Papilloma | X X | 2 |
Lip, Squamous Cell Papilloma | X X X X X | 5 |
Pinna, Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 9| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
1.0 % | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L |
| 5| 4| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
|__________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
3.0 % | 5| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Gallbladder | + + + A A + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Mesentery | + + | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
Squamous Cell Papilloma | X X X X X X | 6 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + M + | 14 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tooth | + + | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
3.0 % | 5| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Odontogenic Tumor | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + M + + + | 14 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M M I M + M M M M M + M M M M | 2 |
|__________________________________________________________________________|____________|
Pituitary Gland | I + I + + + + + + + + I + I + | 11 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
3.0 % | 5| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + | 14 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M | 14 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Squamous Cell Papilloma | X X X X | 4 |
Lip, Squamous Cell Papilloma | X X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 99039-01 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:26:36
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
3.0 % | 5| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | I + + + I + + M + + M I + I I | 8 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 15 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + M + + M + M + + + + + M + M | 10 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
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