TDMS Study 99039-02 Pathology Tables
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
FINAL#3/P53 +/- MICE
Facility: BIORELIANCE
Chemical CAS #: 55589-62-3
Lock Date: 07/20/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
VEHICLE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
VEHICLE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + M + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + M M M + M M + M | 7 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + I + + + M + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Pelvic, Osteosarcoma, Metastatic, | | |
Bone | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + M M I M + M M + M + M | 7 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Vagina | + + + + + + I + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
VEHICLE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 15 |
Femur, Osteosarcoma | X | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + M + M + + M + + I + + + + + | 11 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
VEHICLE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Osteosarcoma, Metastatic, Bone | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + I + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + M + M + + + M + M + M M + M | 8 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + I + | 14 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.3 % | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.3 % | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.0 % | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Uterus | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
Osteosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.0 % | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3.0 % | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Liver | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Salivary Glands | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Tongue | + A + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3.0 % | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Heart | + + + + + + + + + + + + + + + | 15 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + A M M + M + + + + + M + M + | 9 |
|__________________________________________________________________________|____________|
Pituitary Gland | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + A + + + M M + M M + + + M + | 9 |
|__________________________________________________________________________|____________|
Ovary | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Uterus | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Vagina | + A + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3.0 % | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Bone Marrow | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Pancreatic, Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + + + + + + + M + + + + + | 13 |
|__________________________________________________________________________|____________|
Spleen | + A + + + + + + + + + + + + + | 14 |
Histiocytic Sarcoma | X | 1 |
|__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + | 14 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M A + + + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Skin | + A + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + A + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + A + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3.0 % | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + A + + + + + + + I + + I I + | 11 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Nose | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Trachea | + A + + + + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Harderian Gland | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + A + + + + + + + + + + + M M | 12 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + A + + + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + | 14 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Blood Vessel | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + M + + + + | 14 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + + + M + M M M M M | 7 |
|__________________________________________________________________________|____________|
Pituitary Gland | I + + I + + + + + + I + I I I | 9 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + I M I + + + + I + I M + + + | 9 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Lung | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Zymbal's Gland | I + M M M + + M M M M + + M M | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0 % | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Skin | + | 1 |
Pinna, Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
1.0 % | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
Skin | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3.0 % | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3.0 % | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Blood Vessel | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M M + + + + + + M M M | 8 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + + + + + M | 13 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + I + I | 13 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3.0 % | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + M I + M M M I I + + I | 7 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 99039-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: 26-39 WEEKS TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Date: 02/21/03
Route: DOSED FEED Time: 10:29:48
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
P53+/-(C57BL/6) MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3.0 % | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Zymbal's Gland | M M M M M M + + + + M + + + M | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
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