https://ntp.niehs.nih.gov/go/11423

TDMS Study 99039-02 Pathology Tables

NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03
Route: DOSED FEED                                                                                                 Time: 10:32:34
                                                      FINAL#3/P53 +/- MICE
       Facility:  BIORELIANCE
       Chemical CAS #:  55589-62-3
       Lock Date:  07/20/01
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
Note:  Animals arranged according to days on test
                                                              Page   1
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) FEMALE                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|                             |     L      |
    CONTROL                                | 7| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   2                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) FEMALE                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|                             |     L      |
    CONTROL                                | 7| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  M  M  M  M  +  M  M  +  M                              |   7        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  I  +  +  M  +  +  +  +  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   1        |
      Pelvic, Osteosarcoma, Metastatic,    |                                                                          |            |
           Bone                            | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | I  +  +  +  +  M  M  M  +  M  M  +  M  +  M                              |   7        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Vagina                                  | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   3                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) FEMALE                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|                             |     L      |
    CONTROL                                | 7| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Femur, Osteosarcoma                  | X                                                                        |          1 |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | M  +  M  +  M  +  +  +  +  I  +  +  +  +  +                              |  11        |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   4                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) FEMALE                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    VEHICLE                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|                             |     L      |
    CONTROL                                | 7| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Osteosarcoma, Metastatic, Bone       | X                                                                        |          1 |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | +  +  M  +  M  +  +  M  +  M  +  M  M  +  M                              |   8        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +                              |  14        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   5                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) FEMALE                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    0.3 %                                  | 3| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                             |     L      |
                                           | 7| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   1        |
      Sarcoma                              | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) FEMALE                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    0.3 %                                  | 3| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                             |     L      |
                                           | 7| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) FEMALE                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    1.0 %                                  | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|                             |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Uterus                                  |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |   1        |
      Osteosarcoma                         | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) FEMALE                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    1.0 %                                  | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|                             |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |   1        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +                    +                                                   |   2        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) FEMALE                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    3.0 %                                  | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                             |     L      |
                                           | 7| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) FEMALE                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    3.0 %                                  | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                             |     L      |
                                           | 7| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | A  +  M  M  +  M  +  +  +  +  +  M  +  M  +                              |   9        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | A  +  +  +  +  M  M  +  M  M  +  +  +  M  +                              |   9        |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Vagina                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) FEMALE                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    3.0 %                                  | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                             |     L      |
                                           | 7| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                            +                                             |   1        |
      Pancreatic, Histiocytic Sarcoma      |                            X                                             |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | A  +  +  +  +  +  +  +  +  M  +  +  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
      Histiocytic Sarcoma                  |                            X                                             |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
      Histiocytic Sarcoma                  |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  13        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) FEMALE                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    3.0 %                                  | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                             |     L      |
                                           | 7| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
   Larynx                                  | A  +  +  +  +  +  +  +  +  I  +  +  I  I  +                              |  11        |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Nose                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | A  +  +  +  +  +  +  +  +  +  +  +  +  M  M                              |  12        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  14        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Histiocytic Sarcoma                  |                            X                                             |          1 |
      Lymphoma Malignant                   | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) MALE                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |     L      |
    CONTROL                                | 8| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) MALE                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |     L      |
    CONTROL                                | 8| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  M  +  M  M  M  M  M                              |   7        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  I  +  +  I  +  +  +  +  +  I  +  I  I  I                              |   9        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) MALE                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |     L      |
    CONTROL                                | 8| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                              |  14        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                         +                                                |   1        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M                              |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  I  M  I  +  +  +  I  +  I  M  +  +  +                              |   9        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 9| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) MALE                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    VEHICLE                                | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|                             |     L      |
    CONTROL                                | 8| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | M  I  +  M  M  M  +  +  M  M  M  +  +  M  M                              |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) MALE                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    1.0 %                                  | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|                             |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    |                                        +                                 |   1        |
      Pinna, Hemangiosarcoma               |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) MALE                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |     A      |
    1.0 %                                  | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|                             |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
   Skin                                    |                                        +                                 |   1        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                                        +                                 |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) MALE                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    3.0 %                                  | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                             |     L      |
                                           | 9| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Tongue                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) MALE                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    3.0 %                                  | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                             |     L      |
                                           | 9| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  M  M  +  +  +  +  +  +  M  M  M                              |   8        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M                              |  13        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  I  +  I                              |  13        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) MALE                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    3.0 %                                  | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                             |     L      |
                                           | 9| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                           +                              |   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +                              |  14        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M                              |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
      Subcutaneous Tissue, Fibrosarcoma    | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  M  I  +  M  M  M  I  I  +  +  I                              |   7        |
 _____________________________________________________________________________________________________________________|____________|
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 99039-02          NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED)                 Report: PEIRPT17  
Study Type: 26-39 WEEKS                    TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                 Date: 02/21/03    
Route: DOSED FEED                                                                                                 Time: 10:32:34    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |            |
                             DAY ON TEST   | 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                             |            |
                                           | 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                             |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     O      |
   P53+/-(C57BL/6) MALE                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                             |     A      |
    3.0 %                                  | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                             |     L      |
                                           | 9| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                             |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          | M  M  M  M  M  M  +  +  +  +  M  +  +  +  M                              |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                              |  15        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------