NCTR Study 211601 Pathology Tables
NCTR EXP/TEST: 211601 PAGE: 1 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:02.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| S M| | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9| U O| CONTRL F2YR 01 1 | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + M + + + + + + + + + + + + + + + + | | GALLBLADDER | + + + A + + + + M + + + + + + + + + + + + + + + + | | INTESTINE LARGE | + + + + + A + + A + + + + + + + + + + + + + + + + | | INTESTINE LARGE,CECUM | + + A M + A + A A + + + + + + + + + + + + A + + + | | LYMPHOMA MALIGNANT | X | | INTESTINE LARGE,COLON | + + + + + A + + A + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | INTESTINE LARGE,RECTUM | + + + + + A + A A + + + + + + + + + + + + + + + + | | INTESTINE SMALL | + + A A + A A + A A + + + + + + + + + + + A + + + | | INTESTINE SMALL,DUODENUM | + + A A + A A A A A + + + + + + + + + + + A + + + | | INTESTINE SMALL,ILEUM | + + A A + A A A A A + + + + + + + + + + + A + + + | | INTESTINE SMALL,JEJUNUM | + + A A + A A + A A + + + + + + + + + + + A + + + | | LYMPHOMA MALIGNANT | X | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | X | | HEPATOCELLULAR CARCINOMA | | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X X X | | MESENTERY | + | | LYMPHOMA MALIGNANT | X | | PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA | X | | LYMPHOMA MALIGNANT | X X | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | STOMACH | + + + + + A + + + + + + + + + + + + + + + + + + + | | STOMACH,FORESTOMACH | + + + + + A + + + + + + + + + + + + + + + + + + + | | STOMACH,GLANDULAR | + + + + + A + + + + + + + + + + + + + + + + + + + | | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + + + | | PAPILLOMA SQUAMOUS | X | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | M M + M + + M + + M + M + + + + + + + + + + + + + | | BLOOD VESSEL,AORTA | M M + M + + M + + M + M + + + + + + + + + + + + + | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 2 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:02.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| S M| | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9| U O| CONTRL F2YR 01 1 | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | CARDIOVASCULAR SYSTEM LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + M + + M + + + + + + + + + + + + + + + | | ADRENAL GLAND,CORTEX | + + + + + + M + + M + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ADRENAL GLAND,MEDULLA | + + + + + + M + + M + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | PHEOCHROMOCYTOMA MALIGNANT | | | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | PARATHYROID GLAND | + M + M + + + M M + + M + + + + + + + + + M + + + | | PITUITARY GLAND | + + + M + + + + M + + + + + + + + + + + + + + + + | | ADENOMA,PARS INTERMEDIA | X | | THYROID GLAND | + + + + + + + + M + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENERAL BODY SYSTEM TISSUE NOS | + | | LYMPHOMA MALIGNANT,FAT | X | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | M + + M + + + M + + M + + + + + + + + + + + + + + | | OVARY | + + + + + + + + + + + + + + + + + + + + + + + + + | | CYSTADENOMA | X | | HISTIOCYTIC SARCOMA | X | | LUTEOMA | | | LYMPHOMA MALIGNANT | X | | LYMPHOMA MALIGNANT,PERIOVARIAN TISSUE | X | | UTERUS | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | HISTIOCYTIC SARCOMA | X | | POLYP | | | VAGINA | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X X | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 3 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:02.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| S M| | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9| U O| CONTRL F2YR 01 1 | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + A + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | LYMPHOMA MALIGNANT | X X X | | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA,LUMBAR | X | | LYMPHOMA MALIGNANT,LUMBAR | X | | LYMPHOMA MALIGNANT,MEDIASTINAL | | | LYMPHOMA MALIGNANT,RENAL | X | | LYMPH NODE,MANDIBULAR | + + + + + + + + + + + M + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | LYMPH NODE,MESENTERIC | + + + M + + + + + + + M + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X X X | | SPLEEN | M + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | LYMPHOMA MALIGNANT | X X X X X X | | THYMUS | M M + M + + + + + + + + + + + + + + M + + + + + + | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M + + + + + + + A + + + + + + + + M + + M + + + + | | FIBROSARCOMA | X | | LYMPHOMA MALIGNANT | X | | SKIN | + + + + M M + + A + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + A + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | + + + + + A + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + + + A + + + + + + + + + + + + + + + + + + + | | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 4 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:02.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| S M| | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9| U O| CONTRL F2YR 01 1 | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | M M M M + + + + + + + + + + + + + + + + + + + + + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X | | NOSE | + + + + + A + + + + + + + + + + + + + + + + + + + | | TRACHEA | + + + + + + + + M + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + A + A A A A A + + + + + + + + + + + A + + + | | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | | | CARCINOMA | | | LYMPHOMA MALIGNANT | X X | | LACRIMAL GLAND | + + + M + + M M + M + + + + + + + + + M + + + + + | | LYMPHOMA MALIGNANT | X | | ZYMBAL'S GLAND | + + M + + M + + + + M + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X X | | URINARY BLADDER | + + A + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 5 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:09.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| S M| | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8| U O| CONTRL F2YR 01 1 | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + | 47 | GALLBLADDER | + + + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE LARGE | + + + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE LARGE,CECUM | + + + + + + + + + + + + + + + + + + + + + + + | 42 | LYMPHOMA MALIGNANT | | 1| INTESTINE LARGE,COLON | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 2| INTESTINE LARGE,RECTUM | + + + + + + + + + + + + + + + + + M + + + + + | 44 | INTESTINE SMALL | + + + + + + + + + + + + + + + + + + + + + + + | 41 | INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + + + + + + + + + + + | 40 | INTESTINE SMALL,ILEUM | + + + + + + + + + + + + + + + + + + + + + + + | 40 | INTESTINE SMALL,JEJUNUM | + + + + + + + + + + + + + + + + + + + + + + + | 41 | LYMPHOMA MALIGNANT | X | 2| LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA | | 1| HEPATOCELLULAR CARCINOMA | X | 1| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X | 6| MESENTERY | | 1 | LYMPHOMA MALIGNANT | | 1| PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | FIBROSARCOMA | | 1| LYMPHOMA MALIGNANT | | 2| SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 3| STOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 47 | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 47 | STOMACH,GLANDULAR | + + + + + + + + + + + + + + + + + + + + + + + | 47 | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PAPILLOMA SQUAMOUS | | 1| ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + | 42 | BLOOD VESSEL,AORTA | + + + + + + + + + + + + + + + + + + + + + + + | 42 | HEART | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 6 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:10.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| S M| | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8| U O| CONTRL F2YR 01 1 | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | CARDIOVASCULAR SYSTEM LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 46 | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| PHEOCHROMOCYTOMA MALIGNANT | X | 1| ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PARATHYROID GLAND | + M + + + + + + M + M + + + + + + + + + M + + | 38 | PITUITARY GLAND | + + + + + + + + + + + + + + + M + + + + + + + | 45 | ADENOMA,PARS INTERMEDIA | X | 2| THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ GENERAL BODY SYSTEM TISSUE NOS | | 1 | LYMPHOMA MALIGNANT,FAT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + + + + + + + M + + + + + + + + + + + + + | 43 | OVARY | + + + + + + + + + + + + + + + + + + + + + + + | 48 | CYSTADENOMA | | 1| HISTIOCYTIC SARCOMA | | 1| LUTEOMA | X | 1| LYMPHOMA MALIGNANT | X | 2| LYMPHOMA MALIGNANT,PERIOVARIAN TISSUE | | 1| UTERUS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA | | 1| HISTIOCYTIC SARCOMA | X | 2| POLYP | X | 1| VAGINA | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | | 2| LYMPHOMA MALIGNANT | | 2| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 7 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:10.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| S M| | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8| U O| CONTRL F2YR 01 1 | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HEMANGIOSARCOMA | | 1| LYMPHOMA MALIGNANT | | 3| LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA,LUMBAR | | 1| LYMPHOMA MALIGNANT,LUMBAR | X | 2| LYMPHOMA MALIGNANT,MEDIASTINAL | X | 1| LYMPHOMA MALIGNANT,RENAL | | 1| LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X | 4| LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + | 46 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X | 6| SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HEMANGIOSARCOMA | | 1| LYMPHOMA MALIGNANT | X X | 8| THYMUS | + + + + + + + M + M + M + + + + + + + + + + + | 41 | LYMPHOMA MALIGNANT | X | 3| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 44 | FIBROSARCOMA | | 1| LYMPHOMA MALIGNANT | | 1| SKIN | + + + + + + + + + + + + + + + + + + + + + + + | 45 | HEMANGIOSARCOMA | X | 1| LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + | 47 | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + | 47 | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 8 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:10.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| S M| | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8| U O| CONTRL F2YR 01 1 | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + + + + + + + + + | 44 | LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR ADENOMA | | 1| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X | 4| NOSE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + | 41 | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ADENOMA | X X | 2| CARCINOMA | X | 1| LYMPHOMA MALIGNANT | | 2| LACRIMAL GLAND | + + + + + + + + + + + + + + + + + + + + M + M | 41 | LYMPHOMA MALIGNANT | | 1| ZYMBAL'S GLAND | + + + + + + + + + + + + M + + + M + + + + + + | 43 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X X | 6| URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X | 3| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 9 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:13.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| S M| | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8| U O| 25MG F2YR 02 2 | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + M + + | | GALLBLADDER | + + + + + + M + + | | INTESTINE LARGE | + A + + + + + + + | | INTESTINE LARGE,CECUM | + A + A + + A + + | | INTESTINE LARGE,COLON | + A + + + + + + + | | INTESTINE LARGE,RECTUM | + A + M + + + + + | | INTESTINE SMALL | + A + A + + A + + | | INTESTINE SMALL,DUODENUM | + A + A + + A + + | | INTESTINE SMALL,ILEUM | + A + A + + A + + | | INTESTINE SMALL,JEJUNUM | + A + A + + A + + | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | X | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X | | MESENTERY | | | PANCREAS | M + + A + + + + + | | LYMPHOMA MALIGNANT | | | SALIVARY GLANDS | + + + + + + + + + | | STOMACH | + + + + + + + + + | | STOMACH,FORESTOMACH | + + + + + + + + + | | STOMACH,GLANDULAR | + + + + + + + + + | | TONGUE | + + + + + + + A + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + M + + + + + | | BLOOD VESSEL,AORTA | + + + M + + + + + | | HEART | + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + M + + + + + + + | | ADRENAL GLAND,CORTEX | + M + + + + + + + | | HISTIOCYTIC SARCOMA | X | | ADRENAL GLAND,MEDULLA | + M + + + + + + + | | ISLETS, PANCREATIC | M + + A + + + + + | | PARATHYROID GLAND | M + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 10 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:14.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| S M| | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8| U O| 25MG F2YR 02 2 | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM PITUITARY GLAND | M M + + M + + + + M + + + + + + + + + + + + + + + | | ADENOMA,PARS DISTALIS | X | | THYROID GLAND | M + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | M M + + + + + + + | | OVARY | + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | UTERUS | + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | VAGINA | + + + + + M + + + | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + | | LYMPH NODE | + + + + + + + + + | | FIBROSARCOMA,INGUINAL | | | LYMPHOMA MALIGNANT,AXILLARY | | | LYMPHOMA MALIGNANT,LUMBAR | | | LYMPHOMA MALIGNANT,MEDIASTINAL | X | | LYMPHOMA MALIGNANT,RENAL | X | | LYMPH NODE,MANDIBULAR | + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LYMPH NODE,MESENTERIC | + + + + M + A + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X | | SPLEEN | + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | THYMUS | + M M + + + M M + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M + M + + + + + | | ADENOMA | X | | SKIN | + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 11 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:14.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| S M| | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8| U O| 25MG F2YR 02 2 | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM HISTIOCYTIC SARCOMA | X | | OSTEOSARCOMA,METASTATIC,BONE | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + | | OSTEOSARCOMA,LUMBAR,VERTEBRA | X | | BONE,FEMUR | + + + + + + + + + | | BONE,STERNUM | + + + + + + + + + | | SKELETAL MUSCLE | + + + + + + + A + + | | FIBROSARCOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + | | PERIPHERAL NERVE | + + + + + + + A + | | SPINAL CORD | + + + + + + + + + | | SPINAL CORD,THORACIC | + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + M M + + M M + + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X | | OSTEOSARCOMA,METASTATIC,BONE | X | | NOSE | + + + + + + + + + | | TRACHEA | + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | A A + A + + A A + | | HARDERIAN GLAND | + + + + + + + A + | | ADENOMA | | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 12 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:14.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| S M| | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8| U O| 25MG F2YR 02 2 | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM LACRIMAL GLAND | + + + + + M M M + | | ZYMBAL'S GLAND | + M + M + M M + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + A + + | | LYMPHOMA MALIGNANT | X | | URINARY BLADDER | + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 13 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:15.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| S M| | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| U O| 25MG F2YR 02 2 | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + | 9 | GALLBLADDER | M | 8 | INTESTINE LARGE | + | 9 | INTESTINE LARGE,CECUM | A | 6 | INTESTINE LARGE,COLON | + | 9 | INTESTINE LARGE,RECTUM | + | 8 | INTESTINE SMALL | + | 7 | INTESTINE SMALL,DUODENUM | + | 7 | INTESTINE SMALL,ILEUM | A | 6 | INTESTINE SMALL,JEJUNUM | A | 6 | LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA | X | 2| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X X X | 5| MESENTERY | + | 1 | PANCREAS | + | 8 | LYMPHOMA MALIGNANT | X | 1| SALIVARY GLANDS | + M | 10 | STOMACH | + | 10 | STOMACH,FORESTOMACH | + | 10 | STOMACH,GLANDULAR | + | 10 | TONGUE | + | 9 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | M | 8 | BLOOD VESSEL,AORTA | M | 8 | HEART | + | 10 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + | 9 | ADRENAL GLAND,CORTEX | + | 9 | HISTIOCYTIC SARCOMA | | 1| ADRENAL GLAND,MEDULLA | + | 9 | ISLETS, PANCREATIC | + | 8 | PARATHYROID GLAND | + | 9 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 14 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:15.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| S M| | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| U O| 25MG F2YR 02 2 | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM PITUITARY GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 44 | ADENOMA,PARS DISTALIS | X | 2| THYROID GLAND | + | 9 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + | 8 | OVARY | + + + + + + + + + + + | 29 | LYMPHOMA MALIGNANT | | 1| UTERUS | + + + + + + + + A + + + + | 26 | HISTIOCYTIC SARCOMA | | 1| VAGINA | + | 9 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + | 10 | LYMPH NODE | + + + + | 13 | FIBROSARCOMA,INGUINAL | X | 1| LYMPHOMA MALIGNANT,AXILLARY | X | 1| LYMPHOMA MALIGNANT,LUMBAR | X | 1| LYMPHOMA MALIGNANT,MEDIASTINAL | X | 2| LYMPHOMA MALIGNANT,RENAL | | 1| LYMPH NODE,MANDIBULAR | + + | 11 | LYMPHOMA MALIGNANT | X X | 3| LYMPH NODE,MESENTERIC | + + | 9 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X | 4| SPLEEN | + + + | 14 | LYMPHOMA MALIGNANT | X X X | 6| THYMUS | M | 5 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M | 6 | ADENOMA | | 1| SKIN | + | 10 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 15 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:15.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| S M| | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| U O| 25MG F2YR 02 2 | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM HISTIOCYTIC SARCOMA | | 1| OSTEOSARCOMA,METASTATIC,BONE | | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + | 10 | OSTEOSARCOMA,LUMBAR,VERTEBRA | | 1| BONE,FEMUR | + | 10 | BONE,STERNUM | + | 10 | SKELETAL MUSCLE | + + | 11 | FIBROSARCOMA | X | 2| ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + | 10 | BRAIN,CEREBELLUM | + | 10 | BRAIN,CEREBRUM | + | 10 | PERIPHERAL NERVE | + | 9 | SPINAL CORD | + | 10 | SPINAL CORD,THORACIC | + | 10 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | M | 5 | LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR ADENOMA | | 1| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X X X | 4| OSTEOSARCOMA,METASTATIC,BONE | | 1| NOSE | + | 10 | TRACHEA | M | 9 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | A | 4 | HARDERIAN GLAND | + + | 10 | ADENOMA | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 16 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:15.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| S M| | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0| U O| 25MG F2YR 02 2 | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM LACRIMAL GLAND | M | 6 | ZYMBAL'S GLAND | + | 6 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + | 10 | LYMPHOMA MALIGNANT | X | 2| URINARY BLADDER | + | 10 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 17 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:17.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| S M| | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7| U O| 50MG F2YR 03 3 | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | M + + + | | GALLBLADDER | + M + + | | INTESTINE LARGE | + + A + | | INTESTINE LARGE,CECUM | + + A + | | INTESTINE LARGE,COLON | + + A + | | INTESTINE LARGE,RECTUM | + + A + | | INTESTINE SMALL | + + A + | | LYMPHOMA MALIGNANT | | | INTESTINE SMALL,DUODENUM | + + A + | | INTESTINE SMALL,ILEUM | + + A + | | INTESTINE SMALL,JEJUNUM | + + A + | | HEMANGIOMA | | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | X | | LYMPHOMA MALIGNANT | | | MESENTERY | | | PANCREAS | + + + + | | SALIVARY GLANDS | + + + + | | LYMPHOMA MALIGNANT | X | | STOMACH | + + A + | | STOMACH,FORESTOMACH | + + A + | | STOMACH,GLANDULAR | + + A + | | TONGUE | + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + | | BLOOD VESSEL,AORTA | + + + + | | HEART | + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + | | ADRENAL GLAND,CORTEX | + + + + | | ADRENAL GLAND,MEDULLA | M + + + | | ISLETS, PANCREATIC | + + + + | | PARATHYROID GLAND | M M + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 18 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:17.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| S M| | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7| U O| 50MG F2YR 03 3 | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM PITUITARY GLAND | + + + + + + + + + + + + + + + + + + + + + + + + M | | THYROID GLAND | + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + M M + | | OVARY | M + + + + + + + + + + + | | CYSTADENOMA | X | | UTERUS | + + + + + + + + + + + + + + + | | LEIOMYOMA | | | VAGINA | + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + | | LYMPH NODE | + + + + + + | | LYMPHOMA MALIGNANT,DEEP CERVICAL | | | LYMPHOMA MALIGNANT,LUMBAR | X | | LYMPHOMA MALIGNANT,RENAL | X X | | LYMPH NODE,MANDIBULAR | + + M + + | | LYMPHOMA MALIGNANT | X X | | LYMPH NODE,MESENTERIC | + + + + + | | LYMPHOMA MALIGNANT | X | | SPLEEN | + + + + + + + + + + + | | HEMANGIOSARCOMA | | | LYMPHOMA MALIGNANT | X X X X X | | THYMUS | + + + + + | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M + + + | | ADENOCARCINOMA | | | SKIN | + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 19 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:17.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| S M| | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7| U O| 50MG F2YR 03 3 | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | MUSCULOSKELETAL SYSTEM BONE | + + + + | | BONE,FEMUR | + + + + | | BONE,STERNUM | + + + + | | SKELETAL MUSCLE | + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + | | BRAIN,CEREBELLUM | + + + + | | BRAIN,CEREBRUM | + + + + | | PERIPHERAL NERVE | + + + + | | SPINAL CORD | + + + + | | SPINAL CORD,THORACIC | + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | M M M + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X | | LYMPHOMA MALIGNANT | X | | NOSE | + + + + | | TRACHEA | M + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + | | HARDERIAN GLAND | + + + + | | LYMPHOMA MALIGNANT | X | | LACRIMAL GLAND | + M + + | | ZYMBAL'S GLAND | M M + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + | | URINARY BLADDER | + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 20 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:18.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| S M| | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1| U O| 50MG F2YR 03 3 | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + | 4 | GALLBLADDER | + | 4 | INTESTINE LARGE | A | 3 | INTESTINE LARGE,CECUM | A | 3 | INTESTINE LARGE,COLON | A | 3 | INTESTINE LARGE,RECTUM | A | 3 | INTESTINE SMALL | + + + | 6 | LYMPHOMA MALIGNANT | X | 1| INTESTINE SMALL,DUODENUM | + | 4 | INTESTINE SMALL,ILEUM | A | 3 | INTESTINE SMALL,JEJUNUM | + + | 5 | HEMANGIOMA | X | 1| LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA | X X | 3| LYMPHOMA MALIGNANT | X | 1| MESENTERY | + | 1 | PANCREAS | + | 5 | SALIVARY GLANDS | + | 5 | LYMPHOMA MALIGNANT | | 1| STOMACH | + | 4 | STOMACH,FORESTOMACH | + | 4 | STOMACH,GLANDULAR | + | 4 | TONGUE | + | 5 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + | 5 | BLOOD VESSEL,AORTA | + | 5 | HEART | + | 5 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + | 5 | ADRENAL GLAND,CORTEX | + | 5 | ADRENAL GLAND,MEDULLA | M | 3 | ISLETS, PANCREATIC | + | 5 | PARATHYROID GLAND | + | 3 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 21 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:18.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| S M| | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1| U O| 50MG F2YR 03 3 | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM PITUITARY GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | THYROID GLAND | + | 5 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + | 4 | OVARY | + + + + + + + + + + | 21 | CYSTADENOMA | | 1| UTERUS | + + + + + + + + + + + + + + | 29 | LEIOMYOMA | X | 1| VAGINA | + | 5 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + | 5 | LYMPH NODE | + + | 8 | LYMPHOMA MALIGNANT,DEEP CERVICAL | X | 1| LYMPHOMA MALIGNANT,LUMBAR | | 1| LYMPHOMA MALIGNANT,RENAL | | 2| LYMPH NODE,MANDIBULAR | + | 5 | LYMPHOMA MALIGNANT | | 2| LYMPH NODE,MESENTERIC | + + | 7 | LYMPHOMA MALIGNANT | X | 2| SPLEEN | + + + + + + + + | 19 | HEMANGIOSARCOMA | X | 1| LYMPHOMA MALIGNANT | X X | 7| THYMUS | M | 5 | LYMPHOMA MALIGNANT | | 2| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + | 5 | ADENOCARCINOMA | X | 1| SKIN | + | 5 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 22 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:19.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| S M| | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1| U O| 50MG F2YR 03 3 | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | MUSCULOSKELETAL SYSTEM BONE | + | 5 | BONE,FEMUR | + | 5 | BONE,STERNUM | + | 5 | SKELETAL MUSCLE | + | 5 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + | 5 | BRAIN,CEREBELLUM | + | 5 | BRAIN,CEREBRUM | + | 5 | PERIPHERAL NERVE | + | 5 | SPINAL CORD | + | 5 | SPINAL CORD,THORACIC | + | 5 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | M | 1 | LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR ADENOMA | | 2| LYMPHOMA MALIGNANT | | 1| NOSE | + | 5 | TRACHEA | + | 4 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + | 5 | HARDERIAN GLAND | + + | 6 | LYMPHOMA MALIGNANT | | 1| LACRIMAL GLAND | + | 4 | ZYMBAL'S GLAND | + | 3 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + | 5 | URINARY BLADDER | + | 5 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 23 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:28.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6| S M| | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3| U O| 100MG F2YR 04 4 | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + M + + + + M + + + + + + M + + + + + + + + + + + | | GALLBLADDER | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | INTESTINE LARGE | + + A + A + A + + + + A + + + + + + + + + + + + + | | INTESTINE LARGE,CECUM | + + A + A + A + + + + A M A + + + + + + + + + + + | | INTESTINE LARGE,COLON | + + A + A + A + + + + A + + + + + + + + + + + + + | | INTESTINE LARGE,RECTUM | + + A + A + A + + + + A + A + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | INTESTINE SMALL | + + A + A + A + + + + A + A + + + + + + + + + + + | | INTESTINE SMALL,DUODENUM | + + A + A + A + + + + A + A + + + + + + + + + + + | | POLYP ADENOMATOUS | | | INTESTINE SMALL,ILEUM | A + A + A + A + + + + A + A + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | INTESTINE SMALL,JEJUNUM | A + A + A + A + + + + A + A + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | X | | HEPATOCELLULAR CARCINOMA | X | | HISTIOCYTIC SARCOMA | X X | | LYMPHOMA MALIGNANT | X X X X | | MESENTERY | | | PANCREAS | + + A + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | STOMACH | + + A + + + + + + + + A + + + + + + + + + + + + + | | STOMACH,FORESTOMACH | + + A + + A + + + + + A + + + + + + + + + + + + + | | PAPILLOMA SQUAMOUS | X | | STOMACH,GLANDULAR | + + A + + + + + + + + A + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | M M + + + + + + + + + + + + + + + + + + + + + + + | | BLOOD VESSEL,AORTA | M M + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 24 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:28.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6| S M| | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3| U O| 100MG F2YR 04 4 | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | CARDIOVASCULAR SYSTEM HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + M + + + + + + + + + + + | | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + M + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + M + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ISLETS, PANCREATIC | + + A + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | X X | | PARATHYROID GLAND | + + + + + + + + + + M + + M + + + + + + + + + + M | | PITUITARY GLAND | M + + + M + + + + + M + + + + + + + + + + + + + + | | ADENOMA,PARS DISTALIS | X X X | | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | M + + + + + + + + + + + + M + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | OVARY | + + A + + + + + + + + + + + + + + + + + + + + + + | | CYSTADENOMA | | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X | | LYMPHOMA MALIGNANT,PERIOVARIAN TISSUE | X | | UTERUS | + + A + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X X | | LYMPHOMA MALIGNANT | X | | VAGINA | + + + M + M A + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X X X | | LYMPHOMA MALIGNANT | | | POLYP | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 25 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:28.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6| S M| | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3| U O| 100MG F2YR 04 4 | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM BONE MARROW | + + A + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | LYMPHOMA MALIGNANT | X | | LYMPH NODE | + + A + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LYMPHOMA MALIGNANT,INGUINAL | X | | LYMPHOMA MALIGNANT,LUMBAR | X | | LYMPHOMA MALIGNANT,RENAL | X | | LYMPH NODE,MANDIBULAR | + + A + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X X | | LYMPH NODE,MESENTERIC | A + A + + + + + + + + + + + + + + + + + + + M + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X X X X | | SPLEEN | + + M + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X X | | LYMPHOMA MALIGNANT | X X X X X X X | | THYMUS | M M + + + + + + + + + + + M + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + A M + + + + + + + + + M + + + + + + + + + + + | | ADENOCARCINOMA | X | | SKIN | + + A M + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA | | | HEMANGIOSARCOMA | X X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | M + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 26 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:28.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6| S M| | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3| U O| 100MG F2YR 04 4 | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | PERIPHERAL NERVE | + + + + + + + + + M + + + + + + + + + + + + + + M | | SPINAL CORD | M + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD,THORACIC | M + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + M M M + + + + + M M + + + + + + + + + + + + + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X | | HISTIOCYTIC SARCOMA | X X | | LYMPHOMA MALIGNANT | X X X X X | | OSTEOSARCOMA,METASTATIC,UNCERTAIN PRIMARY | X | | SITE | | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TRACHEA | + M + + + + + + + + + + + M + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | A + A + A A A + + + + A + A + + + + + + + + + + + | | HARDERIAN GLAND | + + + + + + + + + M + + + + + + + + + + + + + + + | | ADENOMA | X X | | LYMPHOMA MALIGNANT | X | | LACRIMAL GLAND | + + A + + + M M + M + + + M + M + + + + + + M + + | | LYMPHOMA MALIGNANT | | | ZYMBAL'S GLAND | M + M M + M + + + + M + M + + + + + + + M + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X X | | URINARY BLADDER | A + M M + + A + + + + + + A + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 27 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:28.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6| S M| | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3| U O| 100MG F2YR 04 4 | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 28 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:36.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| S M| | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| U O| 100MG F2YR 04 4 | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + M + + + + + + + + + + + + + + + | 44 | GALLBLADDER | + + M + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | | 1| INTESTINE LARGE | + + + + + + + + + + + + + + + + + + + + + + + | 44 | INTESTINE LARGE,CECUM | + + + + + + + + + + + + + A + + + + + + + + + | 41 | INTESTINE LARGE,COLON | + + + + + + + + + + + + + A + + + + + + + + + | 43 | INTESTINE LARGE,RECTUM | + + + + + + + + + + + + + + + + + + + + + + + | 43 | LYMPHOMA MALIGNANT | X | 1| INTESTINE SMALL | + + + + + + + + + + + + + A + + + + + + + + + | 42 | INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + A + + + + + + + + + | 42 | POLYP ADENOMATOUS | X | 1| INTESTINE SMALL,ILEUM | + M + + + + + + M + + + + A + + + + + + + + + | 39 | LYMPHOMA MALIGNANT | | 1| INTESTINE SMALL,JEJUNUM | + + + + + + + + + + + + + A + + + + + + + + + | 41 | LYMPHOMA MALIGNANT | | 1| LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA | X | 2| HEPATOCELLULAR CARCINOMA | | 1| HISTIOCYTIC SARCOMA | X | 3| LYMPHOMA MALIGNANT | X X | 6| MESENTERY | + | 1 | PANCREAS | + + + + + + + + + + + + + + + M + + + + + + + | 46 | LYMPHOMA MALIGNANT | X | 3| SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 3| STOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 46 | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 45 | PAPILLOMA SQUAMOUS | | 1| STOMACH,GLANDULAR | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | X | 1| TONGUE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + M + + + + + + | 45 | BLOOD VESSEL,AORTA | + + + + + + + + + + + + + + + + M + + + + + + | 45 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 29 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:36.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| S M| | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| U O| 100MG F2YR 04 4 | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | CARDIOVASCULAR SYSTEM HEART | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | X | 1| LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | | 2| ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + M + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| ISLETS, PANCREATIC | + + + + + + + + + + + + + + + M + + + + + + + | 46 | ADENOMA | | 2| PARATHYROID GLAND | + + + + + M M + M + + + M + + + + + + + + + M | 40 | PITUITARY GLAND | + M M + M + + + + + + + + + M + + + + + + + + | 41 | ADENOMA,PARS DISTALIS | X X | 5| THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + M + + + + + + + + M + + M + + + + + + + + | 43 | LYMPHOMA MALIGNANT | X | 2| OVARY | + M + + + + + + + + + + + + + + + + + + + + + | 46 | CYSTADENOMA | X X | 2| HISTIOCYTIC SARCOMA | X | 2| LYMPHOMA MALIGNANT | X | 2| LYMPHOMA MALIGNANT,PERIOVARIAN TISSUE | X X | 3| UTERUS | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HISTIOCYTIC SARCOMA | X | 3| LYMPHOMA MALIGNANT | X | 2| VAGINA | + + + + + + + + + + + + + + + + + + + + + + + | 45 | HISTIOCYTIC SARCOMA | X | 4| LYMPHOMA MALIGNANT | X | 1| POLYP | X | 2| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 30 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:36.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| S M| | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| U O| 100MG F2YR 04 4 | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HEMANGIOSARCOMA | | 1| LYMPHOMA MALIGNANT | X | 2| LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | | 1| LYMPHOMA MALIGNANT,INGUINAL | | 1| LYMPHOMA MALIGNANT,LUMBAR | X | 2| LYMPHOMA MALIGNANT,RENAL | | 1| LYMPH NODE,MANDIBULAR | + + + + + + + + + M + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | X X | 6| LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + M + + + + + + + + | 44 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X X X | 9| SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HEMANGIOSARCOMA | | 2| LYMPHOMA MALIGNANT | X X X X X | 12| THYMUS | + M + + + + + + + + + + + + + + + + + + + + + | 44 | LYMPHOMA MALIGNANT | X X X | 6| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + + + + + + M + + + + + + + + + | 44 | ADENOCARCINOMA | | 1| SKIN | + + + + + + + + + + + + + + + + + + + + + + + | 46 | FIBROSARCOMA | X X | 2| HEMANGIOSARCOMA | | 2| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + | 47 | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 31 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:37.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| S M| | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| U O| 100MG F2YR 04 4 | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PERIPHERAL NERVE | + + M + + + + + + + + + + + + + + + + + + + + | 45 | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + | 47 | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + + + + + + + + + | 43 | LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR ADENOMA | X X | 4| HISTIOCYTIC SARCOMA | | 2| LYMPHOMA MALIGNANT | X X X X | 9| OSTEOSARCOMA,METASTATIC,UNCERTAIN PRIMARY | | 1| SITE | | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + A + + + + + + + + + | 40 | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ADENOMA | | 2| LYMPHOMA MALIGNANT | X | 2| LACRIMAL GLAND | + + + + + + + + + + + + + + M + + + + + + + + | 40 | LYMPHOMA MALIGNANT | X | 1| ZYMBAL'S GLAND | + + + + + + + + + + + + + + + + + + + + M + + | 40 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X X X X | 8| URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + | 43 | LYMPHOMA MALIGNANT | X X | 3| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 32 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:37.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| S M| | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| U O| 100MG F2YR 04 4 | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 33 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:39.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 1| 1| 1| 1| 1| 1| 1| 1| | 1| 1| 1| 1| 1| 1| 1| 1| | 9| 9| 9| 9| 9| 9| 9| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 1| 1| 1| 1| 1| 1| 1| 1| U O| CONTRL F3MTHR 05 5 | 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + | 8 | GALLBLADDER | + + + + + + + + | 8 | INTESTINE LARGE | + + + + + + + + | 8 | INTESTINE LARGE,CECUM | + + + + + + + + | 8 | INTESTINE LARGE,COLON | + + + + + + + + | 8 | INTESTINE LARGE,RECTUM | + + + + + + + + | 8 | INTESTINE SMALL | + + + + + + + + | 8 | INTESTINE SMALL,DUODENUM | + + + + + + + + | 8 | INTESTINE SMALL,ILEUM | + + + + + + + + | 8 | INTESTINE SMALL,JEJUNUM | + + + + + + + + | 8 | LIVER | + + + + + + + + | 8 | PANCREAS | + + + + + + + + | 8 | SALIVARY GLANDS | + + + + + + + + | 8 | STOMACH | + + + + + + + + | 8 | STOMACH,FORESTOMACH | + + + + + + + + | 8 | STOMACH,GLANDULAR | + + + + + + + + | 8 | TONGUE | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + M + | 7 | BLOOD VESSEL,AORTA | + + + + + + M + | 7 | HEART | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + | 8 | ADRENAL GLAND,CORTEX | + + + + + + + + | 8 | ADRENAL GLAND,MEDULLA | + + + + + + + + | 8 | ISLETS, PANCREATIC | + + + + + + + + | 8 | PARATHYROID GLAND | + + + + + + + M | 7 | PITUITARY GLAND | + + + + + + + + | 8 | THYROID GLAND | + + + + + + + M | 7 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 34 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:39.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 1| 1| 1| 1| 1| 1| 1| 1| | 1| 1| 1| 1| 1| 1| 1| 1| | 9| 9| 9| 9| 9| 9| 9| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 1| 1| 1| 1| 1| 1| 1| 1| U O| CONTRL F3MTHR 05 5 | 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | GENITAL SYSTEM CLITORAL GLAND | + M + + + + + + | 7 | OVARY | + + + + + + + + | 8 | UTERUS | + + + + + + + + | 8 | VAGINA | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + | 8 | LYMPH NODE | + + + + + + + + | 8 | LYMPH NODE,MANDIBULAR | + + + + + + + + | 8 | LYMPH NODE,MESENTERIC | + M + + + + + + | 7 | SPLEEN | + + + + + + + + | 8 | THYMUS | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + | 8 | SKIN | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + | 8 | BONE,FEMUR | + + + + + + + + | 8 | BONE,STERNUM | + + + + + + + + | 8 | SKELETAL MUSCLE | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + | 8 | BRAIN,CEREBELLUM | + + + + + + + + | 8 | BRAIN,CEREBRUM | + + + + + + + + | 8 | PERIPHERAL NERVE | + + + + + + + + | 8 | SPINAL CORD | + + + + + + + + | 8 | SPINAL CORD,THORACIC | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 35 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:39.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 1| 1| 1| 1| 1| 1| 1| 1| | 1| 1| 1| 1| 1| 1| 1| 1| | 9| 9| 9| 9| 9| 9| 9| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 1| 1| 1| 1| 1| 1| 1| 1| U O| CONTRL F3MTHR 05 5 | 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM LARYNX | + + M M M M M + | 3 | LUNG | + + + + + + + + | 8 | NOSE | + + + + + + + + | 8 | TRACHEA | + + + + + + + M | 7 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + | 8 | HARDERIAN GLAND | + + + + + + + + | 8 | LACRIMAL GLAND | + + + + + M + + | 7 | ZYMBAL'S GLAND | + + + + + M + + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + | 8 | URINARY BLADDER | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 36 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:41.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 2| 2| 2| 2| 2| 2| 2| 2| | 1| 1| 1| 1| 1| 1| 1| 1| | 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 2| 2| 2| 2| 2| 2| 2| 2| U O| CONTRL F6MTHR 06 6 | 1| 2| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | M + + + + + + + | 7 | GALLBLADDER | + + + + + + + + | 8 | INTESTINE LARGE | + + + + + + + + | 8 | INTESTINE LARGE,CECUM | + + + + + + + + | 8 | INTESTINE LARGE,COLON | + + + + + + + + | 8 | INTESTINE LARGE,RECTUM | + + + + + + + + | 8 | INTESTINE SMALL | + + + + + + + + | 8 | INTESTINE SMALL,DUODENUM | + + + + + + + + | 8 | INTESTINE SMALL,ILEUM | + + + + + + + + | 8 | INTESTINE SMALL,JEJUNUM | + + + + + + + + | 8 | LIVER | + + + + + + + + | 8 | PANCREAS | + + + + + + + + | 8 | SALIVARY GLANDS | + + + + + + + + | 8 | STOMACH | + + + + + + + + | 8 | STOMACH,FORESTOMACH | + + + + + + + + | 8 | STOMACH,GLANDULAR | + + + + + + + + | 8 | TONGUE | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + M + + + | 7 | BLOOD VESSEL,AORTA | + + + + M + + + | 7 | HEART | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + | 8 | ADRENAL GLAND,CORTEX | + + + + + + + + | 8 | ADRENAL GLAND,MEDULLA | + + + + + + + + | 8 | ISLETS, PANCREATIC | + + + + + + + + | 8 | PARATHYROID GLAND | + M M M + M + + | 4 | PITUITARY GLAND | M + M + M + M M | 3 | THYROID GLAND | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 37 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:41.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 2| 2| 2| 2| 2| 2| 2| 2| | 1| 1| 1| 1| 1| 1| 1| 1| | 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 2| 2| 2| 2| 2| 2| 2| 2| U O| CONTRL F6MTHR 06 6 | 1| 2| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | GENITAL SYSTEM CLITORAL GLAND | + + + + + + + + | 8 | OVARY | + + + + + + + + | 8 | UTERUS | + + + + + + + + | 8 | VAGINA | + + + + M + + + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + | 8 | LYMPH NODE | + + + + + + + + | 8 | LYMPH NODE,MANDIBULAR | + + + + + + + + | 8 | LYMPH NODE,MESENTERIC | + + + + + + + + | 8 | SPLEEN | + + + + + + + + | 8 | THYMUS | + + + + M + + + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + | 8 | SKIN | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + | 8 | BONE,FEMUR | + + + + + + + + | 8 | BONE,STERNUM | + + + + + + + + | 8 | SKELETAL MUSCLE | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + | 8 | BRAIN,CEREBELLUM | + + + + + + + + | 8 | BRAIN,CEREBRUM | + + + + + + + + | 8 | PERIPHERAL NERVE | + + + + + + + + | 8 | SPINAL CORD | + + + + + + + + | 8 | SPINAL CORD,THORACIC | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 38 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:42.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 2| 2| 2| 2| 2| 2| 2| 2| | 1| 1| 1| 1| 1| 1| 1| 1| | 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 2| 2| 2| 2| 2| 2| 2| 2| U O| CONTRL F6MTHR 06 6 | 1| 2| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM LARYNX | + M + M M + M M | 3 | LUNG | + + + + + + + + | 8 | ALVEOLAR/BRONCHIOLAR ADENOMA | X | 1| NOSE | + + + + + + + + | 8 | TRACHEA | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + | 8 | HARDERIAN GLAND | + + + + + + + + | 8 | LACRIMAL GLAND | + + M + M + + + | 6 | ZYMBAL'S GLAND | + + + + + + M + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + | 8 | URINARY BLADDER | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 39 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:44.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 3| 3| 3| 3| 3| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| | 2| 2| 2| 2| 2| 2| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 4| 4| 4| 4| 4| 4| 4| 4| U O| CONTRL F12MTHR07 7 | 0| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + | 8 | GALLBLADDER | + + + + + + + + | 8 | INTESTINE LARGE | + + + + + + + + | 8 | INTESTINE LARGE,CECUM | + + + + + + + + | 8 | INTESTINE LARGE,COLON | + + + + M + + + | 7 | INTESTINE LARGE,RECTUM | + + + + + + + + | 8 | INTESTINE SMALL | + + + + + + + + | 8 | INTESTINE SMALL,DUODENUM | + + + + + + + + | 8 | INTESTINE SMALL,ILEUM | + + + + + + + + | 8 | INTESTINE SMALL,JEJUNUM | + + + + + + + + | 8 | LIVER | + + + + + + + + | 8 | MESENTERY | + | 1 | YOLK SAC CARCINOMA,METASTATIC,OVARY | X | 1| PANCREAS | + + + + + + + + | 8 | SALIVARY GLANDS | + + + + + + + + | 8 | STOMACH | + + + + + + + + | 8 | STOMACH,FORESTOMACH | + + + + + + + + | 8 | STOMACH,GLANDULAR | + + + + + + + + | 8 | TONGUE | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + | 8 | BLOOD VESSEL,AORTA | + + + + + + + + | 8 | HEART | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | M + + + + + + + | 7 | ADRENAL GLAND,CORTEX | M + + + + + + + | 7 | ADRENAL GLAND,MEDULLA | M + + + + + + + | 7 | ISLETS, PANCREATIC | + + + + + + + + | 8 | PARATHYROID GLAND | + M M M + + M M | 3 | PITUITARY GLAND | M M + + + M + + | 5 | THYROID GLAND | + M + + + + M + | 6 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 40 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:44.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 3| 3| 3| 3| 3| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| | 2| 2| 2| 2| 2| 2| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 4| 4| 4| 4| 4| 4| 4| 4| U O| CONTRL F12MTHR07 7 | 0| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | GENITAL SYSTEM CLITORAL GLAND | M + + + + M + + | 6 | OVARY | + + + + + + + + | 8 | YOLK SAC CARCINOMA | X | 1| UTERUS | + + + + + + + + | 8 | VAGINA | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + | 8 | LYMPH NODE | + + + + + + + + | 8 | LYMPH NODE,MANDIBULAR | + + + + + + + + | 8 | LYMPH NODE,MESENTERIC | + + + + + + + + | 8 | SPLEEN | + + + + + + + + | 8 | THYMUS | + + M + + + + + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + | 8 | SKIN | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + | 8 | BONE,FEMUR | + + + + + + + + | 8 | BONE,STERNUM | + + + + + + + + | 8 | SKELETAL MUSCLE | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + | 8 | BRAIN,CEREBELLUM | + + + + + + + + | 8 | BRAIN,CEREBRUM | + + + + + + + + | 8 | PERIPHERAL NERVE | + + + + + + + + | 8 | SPINAL CORD | + + + + + + + + | 8 | SPINAL CORD,THORACIC | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 41 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:44.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 3| 3| 3| 3| 3| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| | 2| 2| 2| 2| 2| 2| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 4| 4| 4| 4| 4| 4| 4| 4| U O| CONTRL F12MTHR07 7 | 0| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM LARYNX | M + + + + + + M | 6 | LUNG | + + + + + + + + | 8 | NOSE | + + + + + + + + | 8 | TRACHEA | + M + + + + M + | 6 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + | 8 | HARDERIAN GLAND | + + + + + + + + | 8 | LACRIMAL GLAND | M + + + + + + + | 7 | ZYMBAL'S GLAND | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + | 8 | URINARY BLADDER | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 42 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:51.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| S M| | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| U O| 100MG F3MTH 08 8 | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + + + | | GALLBLADDER | + + + + A + + + + + + M + + + + + + + + + + + + M | | LYMPHOMA MALIGNANT | X X | | INTESTINE LARGE | + + + A A + + + + + + + A + + + + + + + + + + + + | | INTESTINE LARGE,CECUM | + + + A A + + + + + + + A + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | INTESTINE LARGE,COLON | + + + A A + + + + + + + A + + + + + + + + + + + + | | INTESTINE LARGE,RECTUM | + + + A A + + + + + + + A + + + + + + + + + + + + | | INTESTINE SMALL | + + + A A + + + + + + + A + + + + + + + + + + + + | | INTESTINE SMALL,DUODENUM | + + + A A + + + + + + + A + + + + + + + + + + + + | | INTESTINE SMALL,ILEUM | + + + A A + + + + + + + A + + + + + + + + + M + + | | INTESTINE SMALL,JEJUNUM | + + + A A + + + + + + + A + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | X | | LYMPHOMA MALIGNANT | X X X X | | MESENTERY | | | PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | STOMACH | + + + A A + + + + + + + A + + + + + + + + + + + + | | STOMACH,FORESTOMACH | + + + A A + + + + + + + A + + + + + + + + + + + + | | STOMACH,GLANDULAR | + + + A A + + + + + + + A + + + + + + + + + + + + | | TONGUE | + + + A + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + M M + M + + + + M + + + + + + + + + + + + + + + | | BLOOD VESSEL,AORTA | + M M + M + + + + M + + + + + + + + + + + + + + + | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA,SPINDLE CELL | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 43 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:51.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| S M| | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| U O| 100MG F3MTH 08 8 | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + + + + + + + + + + + | | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | PARATHYROID GLAND | + + + M + + + + + + + M + M M + + + + M M + + M M | | PITUITARY GLAND | + + + M M + + + + + + + + + + + + + + + + + + + M | | ADENOMA,PARS DISTALIS | | | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA,FOLLICULAR CELL | X | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + + + + + + + M + + + + + + + + + + + + + + M | | OVARY | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | TERATOMA BENIGN | | | UTERUS | + + + + + + + + + + + + + + + + + + + + + + + + + | | POLYP | X | | VAGINA | + + + + M + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + M + + + | | LYMPHOMA MALIGNANT | X X | | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT,AXILLARY | X | | LYMPHOMA MALIGNANT,LUMBAR | X | | LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X X | | SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X X | | THYMUS | + M + M M + M + + + + + + + + + + + M M + + + + + | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 44 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:51.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| S M| | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| U O| 100MG F3MTH 08 8 | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + A + + + + + + + + + + + + + + + M + M + + | | ADENOCARCINOMA | | | FIBROSARCOMA,METASTATIC,SKIN | | | SKIN | + + + + + + + + + + + + A + + + + + + + + + + + + | | FIBROSARCOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | SKELETAL MUSCLE | + + + A + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | PERIPHERAL NERVE | + + + A + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + + + + + + + + + + + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X | | ALVEOLAR/BRONCHIOLAR CARCINOMA | X | | LYMPHOMA MALIGNANT | X X | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA,METASTATIC,SKIN | X | | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 45 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:52.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| S M| | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| U O| 100MG F3MTH 08 8 | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | + + + A A + + + + + + + + + + + + + + + + + + + + | | HARDERIAN GLAND | + + + A + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | X | | LYMPHOMA MALIGNANT | X X | | LACRIMAL GLAND | + + M + M + + + + + M M + + + + + + + + + + + + M | | LYMPHOMA MALIGNANT | X | | ZYMBAL'S GLAND | + + + + + + + + + + + + + + + + + + M + + + + + + | | FIBROSARCOMA,METASTATIC,SKIN | X | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | URINARY BLADDER | + + + A M + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 46 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:56.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| S M| | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| U O| 100MG F3MTH 08 8 | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + M + + M + M + M | 36 | GALLBLADDER | + + + + + + + + + + + + + + + | 37 | LYMPHOMA MALIGNANT | | 2| INTESTINE LARGE | + + + + + + + + + + + + + + + | 37 | INTESTINE LARGE,CECUM | + + + + + + + + + + + + + + + | 37 | LYMPHOMA MALIGNANT | | 2| INTESTINE LARGE,COLON | + + + + + + + + + + + + + + + | 37 | INTESTINE LARGE,RECTUM | + + + + + + + + + + + + + + + | 37 | INTESTINE SMALL | + + + + + + + + + + + + + + + | 37 | INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + + + | 37 | INTESTINE SMALL,ILEUM | + + + M + + + + + + + + + + + | 35 | INTESTINE SMALL,JEJUNUM | + + + + + + + + + + + + + + + | 37 | LYMPHOMA MALIGNANT | | 1| LIVER | + + + + + + + + + + + + + + + | 40 | HEPATOCELLULAR ADENOMA | | 1| LYMPHOMA MALIGNANT | X X | 6| MESENTERY | + | 1 | PANCREAS | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | | 2| SALIVARY GLANDS | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | X | 3| STOMACH | + + + + + + + + + + + + + + + | 37 | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + | 37 | STOMACH,GLANDULAR | + + + + + + + + + + + + + + + | 37 | TONGUE | + + + + + + + + + + + + + + + | 39 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + | 36 | BLOOD VESSEL,AORTA | + + + + + + + + + + + + + + + | 36 | HEART | + + + + + + + + + + + + + + + | 40 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + | 40 | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + | 40 | ADENOMA,SPINDLE CELL | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 47 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:56.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| S M| | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| U O| 100MG F3MTH 08 8 | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + | 40 | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | | 1| PARATHYROID GLAND | M + + + + + + + + + + + + + + | 31 | PITUITARY GLAND | + + + + + + + M + + + + + + + | 36 | ADENOMA,PARS DISTALIS | X X X | 3| THYROID GLAND | + + + + + + + + + + + + + + + | 40 | ADENOMA,FOLLICULAR CELL | | 1| LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + + + + + + + + M + + + + | 37 | OVARY | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | X X | 4| TERATOMA BENIGN | X | 1| UTERUS | + + + + + + + + + + + + + + + | 40 | POLYP | | 1| VAGINA | + + + M + + + + + + + + + + + | 38 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + | 39 | LYMPHOMA MALIGNANT | X | 3| LYMPH NODE | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT,AXILLARY | | 1| LYMPHOMA MALIGNANT,LUMBAR | | 1| LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | X X | 4| LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | X X | 6| SPLEEN | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | X X X | 7| THYMUS | + + + + + + + + + + + + + M + | 33 | LYMPHOMA MALIGNANT | X X | 4| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 48 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:56.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| S M| | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| U O| 100MG F3MTH 08 8 | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + + + + + M + + | 36 | ADENOCARCINOMA | X | 1| FIBROSARCOMA,METASTATIC,SKIN | X | 1| SKIN | + + + + + + + + + + + + + + + | 39 | FIBROSARCOMA | X | 2| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + | 40 | BONE,FEMUR | + + + + + + + + + + + + + + + | 40 | BONE,STERNUM | + + + + + + + + + + + + + + + | 40 | SKELETAL MUSCLE | + + + + + + + + + + + + + + + | 39 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + | 40 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + | 40 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + | 40 | PERIPHERAL NERVE | + + + M + + + + + + + + + + + | 38 | LYMPHOMA MALIGNANT | | 1| SPINAL CORD | + + + + + + + + + + + + + + + | 40 | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + | 40 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + | 40 | LUNG | + + + + + + + + + + + + + + + | 40 | ALVEOLAR/BRONCHIOLAR ADENOMA | X | 2| ALVEOLAR/BRONCHIOLAR CARCINOMA | | 1| LYMPHOMA MALIGNANT | X | 3| NOSE | + + + + + + + + + + + + + + + | 40 | FIBROSARCOMA,METASTATIC,SKIN | | 1| TRACHEA | + + + + + + + + + + + + + + + | 40 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 49 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:20:56.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| S M| | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| U O| 100MG F3MTH 08 8 | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + | 38 | HARDERIAN GLAND | + + + + + + + + + + + + + + M | 38 | ADENOMA | X | 2| LYMPHOMA MALIGNANT | | 2| LACRIMAL GLAND | + + + M + + + + + + + + + M + | 33 | LYMPHOMA MALIGNANT | X | 2| ZYMBAL'S GLAND | + + + + + + + M + + + + + + + | 38 | FIBROSARCOMA,METASTATIC,SKIN | | 1| ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | X X X | 6| URINARY BLADDER | + + + M + + + + + + + + + + + | 37 | LYMPHOMA MALIGNANT | | 2| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 50 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:05.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| S M| | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1| U O| 100MG F6MTH 09 9 | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | GALLBLADDER | + A + + + + + + + + + + + + + + + + + + + + + M + | | INTESTINE LARGE | + A + + + + A + A + + + + + + + + + + + + + + + + | | INTESTINE LARGE,CECUM | + A + + + + A + A + + + + + + + + + + + + + + + + | | INTESTINE LARGE,COLON | + A + + + + A + A + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | INTESTINE LARGE,RECTUM | + A + + + + A + A + + + + + + + + + + + + + + + + | | INTESTINE SMALL | + A + + + + A + A + + + + + + + + + + + + + + + + | | INTESTINE SMALL,DUODENUM | + A + + + + A + A + + + + + + + + + + + + + + + + | | INTESTINE SMALL,ILEUM | + A + + + + A + A + + + + + + + + + + + + + + + + | | INTESTINE SMALL,JEJUNUM | + A + + + + A + A + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA,METASTATIC,SKIN | X | | HEPATOCELLULAR ADENOMA | X | | HEPATOCELLULAR CARCINOMA | X | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X | | MESENTERY | + | | FIBROSARCOMA,METASTATIC,SKIN | X | | PANCREAS | + A + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA,METASTATIC,SKIN | X X | | LYMPHOMA MALIGNANT | X X X | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | STOMACH | + A + + + + A + + + + + + + + + + + + + + + + + + | | STOMACH,FORESTOMACH | + A + + + + A + + + + + + + + + + + + + + + + + + | | STOMACH,GLANDULAR | + A + + + + A + + + + + + + + + + + + + + + + + + | | TONGUE | + + + + + + + + A + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | M M + + + + + + + + + + + + + + + + + + + + + + + | | BLOOD VESSEL,AORTA | M M + + + + + + + + + + + + + + + + + + + + + + + | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 51 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:05.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| S M| | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1| U O| 100MG F6MTH 09 9 | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | CARDIOVASCULAR SYSTEM LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + A + + + + + M A + + + + + + + + + + + + + + + + | | ADRENAL GLAND,CORTEX | + A + + + + + M A + + + + + + + + + + + + + + + + | | ADRENAL GLAND,MEDULLA | + A + + + + + M A + + + + + + + + + + + + + + + + | | ISLETS, PANCREATIC | + A + + + + A + M + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | PARATHYROID GLAND | + + M + + M + + + + + + + + + + + M + M + + + + M | | ADENOMA | X | | PITUITARY GLAND | M + + M + + + + + + + + + + + + + + + + + M + + + | | ADENOMA,PARS DISTALIS | X | | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA,FOLLICULAR CELL | X | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ GENERAL BODY SYSTEM TISSUE NOS | + | | FIBROSARCOMA,METASTATIC,SKIN | X | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + + + + M M M + + + + + + + + + M + + M + + + | | LYMPHOMA MALIGNANT | X | | OVARY | + + + + + + + + + + + + + + + + + + + + + + + + + | | CYSTADENOMA | X X | | FIBROSARCOMA,METASTATIC,SKIN,PERIOVARIAN T| X | | ISSUE | | | LYMPHOMA MALIGNANT | X X | | LYMPHOMA MALIGNANT,PERIOVARIAN TISSUE | X | | UTERUS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | POLYP | X | | VAGINA | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 52 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:05.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| S M| | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1| U O| 100MG F6MTH 09 9 | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT,AXILLARY | X | | LYMPHOMA MALIGNANT,LUMBAR | X | | LYMPHOMA MALIGNANT,MEDIASTINAL | | | LYMPHOMA MALIGNANT,RENAL | X X | | LYMPHOMA MALIGNANT,THORACIC | X | | SQUAMOUS CELL CARCINOMA,METASTATIC,SKIN,LU| X | | MBAR | | | LYMPH NODE,MANDIBULAR | + + + + + M + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X X | | LYMPH NODE,MESENTERIC | + A + + + + M + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA,METASTATIC,SKIN | X | | LYMPHOMA MALIGNANT | X X X | | SPLEEN | + A + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA,METASTATIC,SKIN | X | | LYMPHOMA MALIGNANT | X X X X X X | | THYMUS | + M M M M + M + + + + + + + + + + + + M + + + M + | | FIBROSARCOMA,METASTATIC,SKIN | X | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + M + + + + + + + + + + + + + + + + + | | ADENOCARCINOMA | X | | LYMPHOMA MALIGNANT | X X | | SKIN | + A + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA | X X | | LYMPHOMA MALIGNANT | X X | | SQUAMOUS CELL CARCINOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 53 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:05.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| S M| | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1| U O| 100MG F6MTH 09 9 | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | MUSCULOSKELETAL SYSTEM SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA,METASTATIC,SKIN | X | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | PERIPHERAL NERVE | + + + + + + + + A + + + + + + + + + + + + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | M + M + M M + M + + + + + + + + + + + + + + + + + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOCARCINOMA,METASTATIC,MAMMARY GLAND | X | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X X | | FIBROSARCOMA,METASTATIC,SKIN | X | | LYMPHOMA MALIGNANT | X X X | | SQUAMOUS CELL CARCINOMA,METASTATIC,SKIN | X | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TRACHEA | + + + + + + + + + + M + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + A A A + + A A A + + + + + + + + + + + + + + + + | | HARDERIAN GLAND | + + + + + + + + A + + + + + + + + + + + + + + + + | | ADENOMA | X | | LYMPHOMA MALIGNANT | X | | LACRIMAL GLAND | + + + M + + + + M + + M + + M + + + M + + + M + + | | LYMPHOMA MALIGNANT | X X | | ZYMBAL'S GLAND | M + + + + M + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 54 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:05.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| S M| | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1| U O| 100MG F6MTH 09 9 | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | URINARY SYSTEM KIDNEY | + A + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X X | | URINARY BLADDER | + + + + + + + + A + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 55 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:10.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| S M| | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4| U O| 100MG F6MTH 09 9 | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | | 1| GALLBLADDER | + + + + M + + + + + M + + + + | 36 | INTESTINE LARGE | + + + + + + + + + + + + + + + | 37 | INTESTINE LARGE,CECUM | + + + + + + + + + + + + + + + | 37 | INTESTINE LARGE,COLON | + + + + + + + + + + + + + + + | 37 | LYMPHOMA MALIGNANT | | 1| INTESTINE LARGE,RECTUM | + + + + + + + + + + + + + + + | 37 | INTESTINE SMALL | + + + + + + + + + + + + + + + | 37 | INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + + + | 37 | INTESTINE SMALL,ILEUM | + + + + + + + + + + + + + + + | 37 | INTESTINE SMALL,JEJUNUM | + + + + + + + + + + + + + + + | 37 | LYMPHOMA MALIGNANT | | 1| LIVER | + + + + + + + + + + + + + + + | 40 | FIBROSARCOMA,METASTATIC,SKIN | | 1| HEPATOCELLULAR ADENOMA | | 1| HEPATOCELLULAR CARCINOMA | | 1| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X X X X | 7| MESENTERY | + | 2 | FIBROSARCOMA,METASTATIC,SKIN | | 1| PANCREAS | + + + + + + + + + + + + + + + | 39 | FIBROSARCOMA,METASTATIC,SKIN | | 2| LYMPHOMA MALIGNANT | X X | 5| SALIVARY GLANDS | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | | 3| STOMACH | + + + + + + + + + + + + + + + | 38 | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + | 38 | STOMACH,GLANDULAR | + + + + + + + + + + + + + + + | 38 | TONGUE | + + + + + + + + + + + + + + + | 39 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | M M + + + + + + + + + + M + + | 35 | BLOOD VESSEL,AORTA | M M + + + + + + + + + + M + + | 35 | HEART | + + + + + + + + + + + + + + + | 40 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 56 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:10.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| S M| | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4| U O| 100MG F6MTH 09 9 | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | CARDIOVASCULAR SYSTEM LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + | 37 | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + | 37 | ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + | 37 | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + | 37 | LYMPHOMA MALIGNANT | X | 1| PARATHYROID GLAND | + + + + + + M M + + + + + + + | 33 | ADENOMA | | 1| PITUITARY GLAND | + + + + + + + M + + + + + + + | 36 | ADENOMA,PARS DISTALIS | | 1| THYROID GLAND | + + + + + + + + + + + + + + + | 40 | ADENOMA,FOLLICULAR CELL | | 1| LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ GENERAL BODY SYSTEM TISSUE NOS | | 1 | FIBROSARCOMA,METASTATIC,SKIN | | 1| ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + + + + + M + + + + M + + | 33 | LYMPHOMA MALIGNANT | | 1| OVARY | + + + + + + + + + + M + + + + | 39 | CYSTADENOMA | | 2| FIBROSARCOMA,METASTATIC,SKIN,PERIOVARIAN T| | 1| ISSUE | | | LYMPHOMA MALIGNANT | | 2| LYMPHOMA MALIGNANT,PERIOVARIAN TISSUE | X X X | 4| UTERUS | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | | 1| POLYP | | 1| VAGINA | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 57 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:11.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| S M| | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4| U O| 100MG F6MTH 09 9 | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | X X | 2| LYMPH NODE | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT,AXILLARY | | 1| LYMPHOMA MALIGNANT,LUMBAR | | 1| LYMPHOMA MALIGNANT,MEDIASTINAL | X | 1| LYMPHOMA MALIGNANT,RENAL | X | 3| LYMPHOMA MALIGNANT,THORACIC | | 1| SQUAMOUS CELL CARCINOMA,METASTATIC,SKIN,LU| | 1| MBAR | | | LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + | 39 | LYMPHOMA MALIGNANT | X X | 6| LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + | 38 | FIBROSARCOMA,METASTATIC,SKIN | | 1| LYMPHOMA MALIGNANT | X X X | 6| SPLEEN | + + + + + + + + + + + + + + + | 39 | FIBROSARCOMA,METASTATIC,SKIN | | 1| LYMPHOMA MALIGNANT | X X X X X | 11| THYMUS | M + + M + + + + + + + + + + + | 31 | FIBROSARCOMA,METASTATIC,SKIN | | 1| LYMPHOMA MALIGNANT | X X X | 5| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + + + + M + + + | 38 | ADENOCARCINOMA | | 1| LYMPHOMA MALIGNANT | | 2| SKIN | + + + + + + + + + + + + + + + | 39 | FIBROSARCOMA | | 2| LYMPHOMA MALIGNANT | | 2| SQUAMOUS CELL CARCINOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + | 40 | BONE,FEMUR | + + + + + + + + + + + + + + + | 40 | BONE,STERNUM | + + + + + + + + + + + + + + + | 40 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 58 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:11.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| S M| | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4| U O| 100MG F6MTH 09 9 | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | MUSCULOSKELETAL SYSTEM SKELETAL MUSCLE | + + + + + + + + + + + + + + + | 40 | FIBROSARCOMA,METASTATIC,SKIN | | 1| LYMPHOMA MALIGNANT | | 2| ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + | 40 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | | 2| BRAIN,CEREBRUM | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | | 1| PERIPHERAL NERVE | + + + + + + + + + + + + + + + | 39 | SPINAL CORD | + + + + + + + + + + + + + + + | 40 | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + | 40 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + M + + + | 34 | LUNG | + + + + + + + + + + + + + + + | 40 | ADENOCARCINOMA,METASTATIC,MAMMARY GLAND | | 1| ALVEOLAR/BRONCHIOLAR ADENOMA | | 4| FIBROSARCOMA,METASTATIC,SKIN | | 1| LYMPHOMA MALIGNANT | X | 4| SQUAMOUS CELL CARCINOMA,METASTATIC,SKIN | | 1| NOSE | + + + + + + + + + + + + + + + | 40 | TRACHEA | + + + + + + + + + + + + + + + | 39 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + | 34 | HARDERIAN GLAND | + + + + + + M + + + + + + + + | 38 | ADENOMA | X | 2| LYMPHOMA MALIGNANT | | 1| LACRIMAL GLAND | + + + + + + M + + + + + + + + | 33 | LYMPHOMA MALIGNANT | | 2| ZYMBAL'S GLAND | + + M M + + + + + + + + + + + | 36 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 59 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:11.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| S M| | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4| U O| 100MG F6MTH 09 9 | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + | 39 | LYMPHOMA MALIGNANT | X X X | 7| URINARY BLADDER | + + + + + + + + + + + + + + + | 39 | LYMPHOMA MALIGNANT | | 2| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 60 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:17.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| S M| | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1| U O| 100MG F12MTH 10 10 | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + A + + + + + + + + + + + + + + + + + + + + + + | | GALLBLADDER | + A + A A + + + + + + + + + + + + + + + + + + + + | | INTESTINE LARGE | A + A + A A A + + M + + + + + + + + + + + + + + + | | INTESTINE LARGE,CECUM | A A A A A A A + + M + + + + + + + + + + + + + + + | | INTESTINE LARGE,COLON | A + A + A A A + + M + + + + + + + + + + + + + + + | | INTESTINE LARGE,RECTUM | A + A M A A A + + M + + + + + + + + + + + + + + M | | INTESTINE SMALL | A A A A A A A + + + + + + + + + + + + + + + + + + | | INTESTINE SMALL,DUODENUM | A A A A A A A + + + + + + + + + + + + + + + + + + | | INTESTINE SMALL,ILEUM | A A A A A A A + + M + + + + + + + + + + + + + + M | | INTESTINE SMALL,JEJUNUM | A A A A A A A + + M + + + + + + + + + + + + + + + | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | X X | | HEPATOCELLULAR CARCINOMA | | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X X X | | PANCREAS | + + A + A + A + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | SALIVARY GLANDS | + + + + + + M + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | STOMACH | + + A A A + A + + + + + + + + + + + + + + + + + + | | STOMACH,FORESTOMACH | A + A A A + A + + + + + + + + + + + + + + + + + + | | STOMACH,GLANDULAR | + + A A A + A + + + + + + + + + + + + + + + + + + | | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + M + + + + + + + + + + + + + + + + + + | | BLOOD VESSEL,AORTA | + + + + + + M + + + + + + + + + + + + + + + + + + | | HEART | + A + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + A M + + A + + + + + + + + + + + + + + + + + + | | ADRENAL GLAND,CORTEX | + + A M + + A + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ADRENAL GLAND,MEDULLA | + + A M + + A + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 61 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:18.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| S M| | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1| U O| 100MG F12MTH 10 10 | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ISLETS, PANCREATIC | + + A + A + + + + + + + + + + + + + + + + + + + + | | PARATHYROID GLAND | + + A + M + + + + + + + M + + + + + + + + + + + + | | PITUITARY GLAND | + + A M + + + + + + + + M + + + + + + + M + + + + | | ADENOMA,PARS DISTALIS | | | THYROID GLAND | + + A + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + A + + + M + + + + + M + + + + + + + M + + M + | | OVARY | + + M + + + M + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT,PERIOVARIAN TISSUE | X X X | | TERATOMA BENIGN | X | | UTERUS | + + A + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X | | SARCOMA STROMAL | X | | VAGINA | + A A + A + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X X | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + A A + + + + + + + + + + + + + + + + + + + + | | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LYMPHOMA MALIGNANT,THORACIC | X | | LYMPH NODE,MANDIBULAR | + + + + + + M + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X X X | | LYMPH NODE,MESENTERIC | + + + + A + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X X X X | | SPLEEN | + + + + A + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X | | THYMUS | + + A M + M M + + + + + + + + + + + M + + + + + M | | LYMPHOMA MALIGNANT | X X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 62 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:18.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| S M| | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1| U O| 100MG F12MTH 10 10 | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | + A + M + + A + + + + + + + + + + + + + + + + + + | | ADENOACANTHOMA | X | | SKIN | + + M + + + A + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | SKELETAL MUSCLE | + + + + + + M + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | PERIPHERAL NERVE | + + + + + + M + + + + + M + + + + + + + + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + M | | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + + M | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + M A M M + + + + + + + M + + + + + + + + + + + + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOACANTHOMA,METASTATIC,MAMMARY GLAND | X | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X X X | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TRACHEA | + + A + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | A A A + A A + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA,RETROBULBAR | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 63 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:18.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| S M| | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1| U O| 100MG F12MTH 10 10 | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM HARDERIAN GLAND | + + A + + + M + + + + + + + + + + + + + + + + + + | | ADENOMA | | | LACRIMAL GLAND | + M + + + + M + + + + + M + + + + + + + + + + + M | | LYMPHOMA MALIGNANT | X X | | ZYMBAL'S GLAND | + + + + + M M + + + + + + M + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + A + + + A + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X X | | URINARY BLADDER | + + A + A A A + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 64 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:22.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| S M| | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5| U O| 100MG F12MTH 10 10 | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + M + + + + + + + + + + + | 38 | GALLBLADDER | + + + + + + + + + + + + M + + | 36 | INTESTINE LARGE | + + + + + + + + + + + + + + + | 34 | INTESTINE LARGE,CECUM | + + + + + + + + + + + + + + + | 32 | INTESTINE LARGE,COLON | + + + + + + + + + + + + + + + | 34 | INTESTINE LARGE,RECTUM | + + + + + + + + + + + + + + + | 32 | INTESTINE SMALL | + + + + + + + + + + + + + + + | 33 | INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + + + | 33 | INTESTINE SMALL,ILEUM | + + + + + + + + + + + + + + + | 31 | INTESTINE SMALL,JEJUNUM | + + + + + + + + + + + + + + + | 32 | LIVER | + + + + + + + + + + + + + + + | 40 | HEPATOCELLULAR ADENOMA | | 2| HEPATOCELLULAR CARCINOMA | X X | 2| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X X X | 8| PANCREAS | + + + + + + + + + + + + + + + | 37 | LYMPHOMA MALIGNANT | X | 1| SALIVARY GLANDS | + + + + + + + + + + + + + + + | 39 | LYMPHOMA MALIGNANT | | 2| STOMACH | + + + + + + + + + + + + + + + | 36 | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + | 35 | STOMACH,GLANDULAR | + + + + + + + + + + + + + + + | 36 | TONGUE | + + + + + + + + + + + + + + + | 40 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + M + + + + + + M + + + + + | 37 | BLOOD VESSEL,AORTA | + + M + + + + + + M + + + + + | 37 | HEART | + + + + + + + + + + + + + + + | 39 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + | 37 | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + | 37 | LYMPHOMA MALIGNANT | | 1| ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + | 37 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 65 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:22.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| S M| | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5| U O| 100MG F12MTH 10 10 | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ISLETS, PANCREATIC | + + + + + + + + + + + + + + + | 38 | PARATHYROID GLAND | + + + + + + + M + + + + + + + | 36 | PITUITARY GLAND | + + + + + + + M + + + + M + M | 33 | ADENOMA,PARS DISTALIS | X | 1| THYROID GLAND | + + + + + + + + + + + + + + + | 39 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + M + + + + + + + + + + + + M | 33 | OVARY | + + + + + + + + + + + + + + + | 38 | LYMPHOMA MALIGNANT,PERIOVARIAN TISSUE | | 3| TERATOMA BENIGN | | 1| UTERUS | + + + + + + + + + + + + + + + | 39 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | | 1| SARCOMA STROMAL | | 1| VAGINA | + + + + + + + + + + + + + + + | 37 | HISTIOCYTIC SARCOMA | | 2| ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + | 38 | LYMPH NODE | + + + + + + + + + + + + + + + | 40 | LYMPHOMA MALIGNANT | | 1| LYMPHOMA MALIGNANT,THORACIC | | 1| LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + | 39 | LYMPHOMA MALIGNANT | X X | 7| LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + | 39 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X X | 8| SPLEEN | + + + + + + + + + + + + + + + | 39 | HEMANGIOSARCOMA | X | 1| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X X X X X X | 8| THYMUS | + M + + + + + M M + + + M + + | 30 | LYMPHOMA MALIGNANT | X X | 5| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 66 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:22.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| S M| | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5| U O| 100MG F12MTH 10 10 | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + M + + + + + + + + + + | 36 | ADENOACANTHOMA | | 1| SKIN | + + + + + + + + + + + + + + + | 38 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + | 40 | BONE,FEMUR | + + + + + + + + + + + + + + + | 40 | BONE,STERNUM | + + + + + + + + + + + + + + + | 40 | SKELETAL MUSCLE | + + + + + + + + + + + + + + + | 39 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + | 40 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + | 40 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + | 40 | PERIPHERAL NERVE | + + + + + + + + + + + + + + + | 38 | SPINAL CORD | + + + + + + + + + + + + + + + | 39 | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + | 39 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + M + + + + + + + + | 34 | LUNG | + + + + + + + + + + + + + + + | 40 | ADENOACANTHOMA,METASTATIC,MAMMARY GLAND | | 1| ALVEOLAR/BRONCHIOLAR ADENOMA | X X X X | 7| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X X X | 8| NOSE | + + + + + + + + + + + + + + + | 40 | TRACHEA | + + + + + + + + + + + + + + + | 39 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + | 35 | HISTIOCYTIC SARCOMA,RETROBULBAR | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 67 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:22.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| S M| | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5| U O| 100MG F12MTH 10 10 | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM HARDERIAN GLAND | + + + + + + + + + + + + + + + | 38 | ADENOMA | X X X | 3| LACRIMAL GLAND | M M + + + + M + + M + + + + + | 32 | LYMPHOMA MALIGNANT | | 2| ZYMBAL'S GLAND | + + + M + + + + + + + + + + + | 36 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + | 38 | LYMPHOMA MALIGNANT | X | 5| URINARY BLADDER | + + + + + + + + + + + + + + + | 36 | LYMPHOMA MALIGNANT | | 3| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 68 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:29.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| S M| | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6| U O| CONTRL FS-2YR 11 11 | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + + + | | GALLBLADDER | + A A + + + + + + + + + + + + + M + + + + M + + + | | INTESTINE LARGE | + A A + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE LARGE,CECUM | + A A + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | INTESTINE LARGE,COLON | + A A + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE LARGE,RECTUM | + A A + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE SMALL | + A A + + A + + + + + + + + + + + + + + + + + + + | | INTESTINE SMALL,DUODENUM | + A A + + A + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | INTESTINE SMALL,ILEUM | + A A + + A + + + + + + + + + + + + M + + + + + + | | LYMPHOMA MALIGNANT | | | INTESTINE SMALL,JEJUNUM | + A A + + A + + + + + + + + + + + + M + + + + + + | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | X X | | HEPATOCELLULAR CARCINOMA | X X | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X X | | MESENTERY | + | | PANCREAS | + A A + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | STOMACH | + A + + + + + + + + + + + + + + + + + + + + + + + | | STOMACH,FORESTOMACH | + A + + + + + + + + + + + + + + + + + + + + + + + | | SQUAMOUS CELL CARCINOMA | | | STOMACH,GLANDULAR | + A + + + + + + + + + + + + + + + + + + + + + + + | | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | M + + + + + + + + + + + + + + + + + + + + + + + + | | BLOOD VESSEL,AORTA | M + + + + + + + + + + + + + + + + + + + + + + + + | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 69 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:29.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| S M| | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6| U O| CONTRL FS-2YR 11 11 | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + A + + + + + + + + + + + + + + + + + + + + + + + | | ADRENAL GLAND,CORTEX | + A + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ADRENAL GLAND,MEDULLA | + A + + + + + + + + + + + + + + + + + + + + + + + | | ISLETS, PANCREATIC | + A A + + + + + + + + + + + + + + + + + + + + + + | | PARATHYROID GLAND | M + + + M + + + + + + + + + + + + M M + M + + + M | | PITUITARY GLAND | M + + + M + M + + + + + + + + + M + + + + + + + + | | ADENOMA,PARS DISTALIS | | | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + M M + + + + + + M + M + + + + + + + + M M + | | OVARY | + A + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT,PERIOVARIAN TISSUE | | | UTERUS | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | POLYP | | | VAGINA | + + A + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LYMPHOMA MALIGNANT,LUMBAR | X | | LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LYMPH NODE,MESENTERIC | + + + + M + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | SPLEEN | + A + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X X | | THYMUS | M + M + M M + M M + + + + + + M + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 70 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:29.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| S M| | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6| U O| CONTRL FS-2YR 11 11 | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + M + M + + + + + + + + + + + + + + + + + + + + | | SKIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + M M M + + + + + + + + M + + + + + + + + + + + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X | | ALVEOLAR/BRONCHIOLAR ADENOMA,MULTIPLE | | | CARCINOMA,METASTATIC,HARDERIAN GLAND | | | LYMPHOMA MALIGNANT | X X X | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | CARCINOMA,METASTATIC,HARDERIAN GLAND | | | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 71 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:29.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| S M| | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6| U O| CONTRL FS-2YR 11 11 | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | + A A + + A + + + + + + + + + + + + + + + + + + + | | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | X | | CARCINOMA | | | LYMPHOMA MALIGNANT | X | | LACRIMAL GLAND | + + + + M M + + + + + M M + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ZYMBAL'S GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | URINARY BLADDER | + + M + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 72 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:35.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| S M| | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0| U O| CONTRL FS-2YR 11 11 | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + M + + + + + + + + M + M + + + + | 45 | GALLBLADDER | + + + + + + M + + + + + + + + + + + + + + + + | 43 | INTESTINE LARGE | + + + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE LARGE,CECUM | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | X | 2| INTESTINE LARGE,COLON | + + + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE LARGE,RECTUM | + + + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE SMALL | + + + + + + + + + + + + + + + + + + + + + + + | 45 | INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + + + + + + + + + + + | 45 | LYMPHOMA MALIGNANT | X | 1| INTESTINE SMALL,ILEUM | + + + + + + + + + + + + M + + + + + + + + M + | 42 | LYMPHOMA MALIGNANT | X | 1| INTESTINE SMALL,JEJUNUM | + + + + + + + + + + + + + + + + + + + + + + + | 44 | LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA | X | 3| HEPATOCELLULAR CARCINOMA | X | 3| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X | 5| MESENTERY | + | 2 | PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | X | 2| SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 1| STOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 47 | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 47 | SQUAMOUS CELL CARCINOMA | X | 1| STOMACH,GLANDULAR | + + + + + + + + + + + + + + + + + + + + + + + | 47 | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + M + + + + + + + + + + + + + + + + | 46 | BLOOD VESSEL,AORTA | + + + + + + M + + + + + + + + + + + + + + + + | 46 | HEART | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 73 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:35.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| S M| | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0| U O| CONTRL FS-2YR 11 11 | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | M + + + + + + + + + + + + + + + + + + + + + + | 46 | ADRENAL GLAND,CORTEX | M + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| ADRENAL GLAND,MEDULLA | M + + + + + + + + + + + + + + + + + + + + + + | 46 | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + | 46 | PARATHYROID GLAND | + + + + M + + + + M + M + + + M + + + + + + + | 38 | PITUITARY GLAND | + + + + + M M M + + + + + + M + + + + + + + + | 40 | ADENOMA,PARS DISTALIS | X | 1| THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + + M + + M + + + + + + + + + + + + M + M | 38 | OVARY | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT,PERIOVARIAN TISSUE | X | 1| UTERUS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | | 1| POLYP | X | 1| VAGINA | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HISTIOCYTIC SARCOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 3| LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 1| LYMPHOMA MALIGNANT,LUMBAR | | 1| LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 2| LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X X | 4| SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X X X | 7| THYMUS | + + M + + + + + + + + + M + + + + + + + + + M | 38 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 74 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:36.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| S M| | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0| U O| CONTRL FS-2YR 11 11 | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT | X | 2| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 46 | SKIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | FIBROSARCOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + + + + + + + + + | 44 | LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR ADENOMA | X X | 3| ALVEOLAR/BRONCHIOLAR ADENOMA,MULTIPLE | X | 1| CARCINOMA,METASTATIC,HARDERIAN GLAND | X | 1| LYMPHOMA MALIGNANT | | 3| NOSE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | CARCINOMA,METASTATIC,HARDERIAN GLAND | X | 1| TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 75 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:36.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| S M| | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0| U O| CONTRL FS-2YR 11 11 | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + | 45 | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ADENOMA | | 1| CARCINOMA | X | 1| LYMPHOMA MALIGNANT | | 1| LACRIMAL GLAND | M + + + + + + + + + + + + + + M + + + M + + + | 41 | LYMPHOMA MALIGNANT | | 1| ZYMBAL'S GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 2| URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 76 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:39.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| S M| | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5| U O| 10MG FS-2YR 12 12 | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + | | LYMPHOMA MALIGNANT | X | | GALLBLADDER | + + + + + + + | | LYMPHOMA MALIGNANT | X | | INTESTINE LARGE | A + + + + + + | | INTESTINE LARGE,CECUM | A + A + + + + | | INTESTINE LARGE,COLON | A + + + + + + | | INTESTINE LARGE,RECTUM | A + + + + + + | | INTESTINE SMALL | A + A + + + + + + | | INTESTINE SMALL,DUODENUM | A + A + + + + + | | LYMPHOMA MALIGNANT | X | | INTESTINE SMALL,ILEUM | A + A + + + + | | INTESTINE SMALL,JEJUNUM | A + A + + + + + | | LYMPHOMA MALIGNANT | X | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | X | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X X X X X | | MESENTERY | + + + + | | SARCOMA | X | | PANCREAS | A + + + + + + + | | LYMPHOMA MALIGNANT | X X | | SALIVARY GLANDS | + + + + + + + | | LYMPHOMA MALIGNANT | X X | | STOMACH | A + + + + + + | | STOMACH,FORESTOMACH | A + + + + + + | | LYMPHOMA MALIGNANT | X X | | STOMACH,GLANDULAR | A + + + + + + | | LYMPHOMA MALIGNANT | X X | | TONGUE | + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + M + + + + + | | BLOOD VESSEL,AORTA | + M + + + + + | | HEART | + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 77 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:39.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| S M| | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5| U O| 10MG FS-2YR 12 12 | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + | | FIBROSARCOMA,METASTATIC,SKIN | X | | ADRENAL GLAND,CORTEX | + + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X | | ADRENAL GLAND,MEDULLA | + + + + + + + | | ISLETS, PANCREATIC | A + + + + + + | | LYMPHOMA MALIGNANT | X | | PARATHYROID GLAND | + + + + + + + | | PITUITARY GLAND | A + + + M + M | | THYROID GLAND | + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + + + + + | | LYMPHOMA MALIGNANT | X | | OVARY | + + + + + + + + + + + + + + | | CYSTADENOMA | X | | LYMPHOMA MALIGNANT | X X | | SARCOMA | X | | UTERUS | + + + + + + + + + + + + + + + | | LEIOMYOMA | X | | LYMPHOMA MALIGNANT | X | | VAGINA | + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + | | LYMPHOMA MALIGNANT | X X | | LYMPH NODE | + + + + + + + + + | | LYMPHOMA MALIGNANT,AXILLARY | X | | LYMPHOMA MALIGNANT,INGUINAL | X | | LYMPHOMA MALIGNANT,MEDIASTINAL | | | LYMPHOMA MALIGNANT,RENAL | X | | LYMPH NODE,MANDIBULAR | + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 78 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:39.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| S M| | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5| U O| 10MG FS-2YR 12 12 | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT | X X | | LYMPH NODE,MESENTERIC | + + + + M + + + | | LYMPHOMA MALIGNANT | X X | | SARCOMA | X | | SPLEEN | + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | LYMPHOMA MALIGNANT | X X X X X X X X X | | THYMUS | + + + M M + + | | LYMPHOMA MALIGNANT | X X | | SARCOMA,METASTATIC,SKIN | X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | A + + M + + + | | ADENOCARCINOMA | X | | FIBROUS HISTIOCYTOMA | X | | LYMPHOMA MALIGNANT | X | | SKIN | A + + + + + + + | | FIBROSARCOMA | X | | HEMANGIOSARCOMA,METASTATIC,UNCERTAIN PRIMA| X | | RY SITE | | | LYMPHOMA MALIGNANT | X | | SARCOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + | | BONE,FEMUR | + + + + + + + | | LYMPHOMA MALIGNANT | X | | BONE,STERNUM | + + + + + + + | | LYMPHOMA MALIGNANT | X | | SKELETAL MUSCLE | + + + + + + + | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 79 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:39.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| S M| | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5| U O| 10MG FS-2YR 12 12 | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | NERVOUS SYSTEM BRAIN | + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + | | LYMPHOMA MALIGNANT | X | | BRAIN,CEREBRUM | + + + + + + + | | LYMPHOMA MALIGNANT | X | | PERIPHERAL NERVE | + + + + + + + | | LYMPHOMA MALIGNANT | X | | SPINAL CORD | + + + + + + + | | SPINAL CORD,THORACIC | + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + M M + M M + | | LUNG | + + + + + + + | | FIBROUS HISTIOCYTOMA | X | | LYMPHOMA MALIGNANT | X X X | | SARCOMA,METASTATIC,SKIN | X | | NOSE | + + + + + + + | | LYMPHOMA MALIGNANT | X | | TRACHEA | + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | A + A A + + + | | HARDERIAN GLAND | + + + + + + + + | | ADENOMA | X | | LYMPHOMA MALIGNANT | X X | | LACRIMAL GLAND | + M M M + + + | | LYMPHOMA MALIGNANT | X | | ZYMBAL'S GLAND | M + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 80 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:40.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| S M| | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5| U O| 10MG FS-2YR 12 12 | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | URINARY SYSTEM KIDNEY | + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | URETER | | | LYMPHOMA MALIGNANT | | | URINARY BLADDER | + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 81 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:41.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| S M| | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9| U O| 10MG FS-2YR 12 12 | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | M | 7 | LYMPHOMA MALIGNANT | | 1| GALLBLADDER | + | 8 | LYMPHOMA MALIGNANT | X | 2| INTESTINE LARGE | + | 7 | INTESTINE LARGE,CECUM | + | 6 | INTESTINE LARGE,COLON | + | 7 | INTESTINE LARGE,RECTUM | + | 7 | INTESTINE SMALL | + | 8 | INTESTINE SMALL,DUODENUM | + | 7 | LYMPHOMA MALIGNANT | | 1| INTESTINE SMALL,ILEUM | + | 6 | INTESTINE SMALL,JEJUNUM | + | 7 | LYMPHOMA MALIGNANT | | 1| LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA | X X | 3| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X X X | 10| MESENTERY | | 4 | SARCOMA | | 1| PANCREAS | + | 8 | LYMPHOMA MALIGNANT | | 2| SALIVARY GLANDS | + + | 9 | LYMPHOMA MALIGNANT | X | 3| STOMACH | + | 7 | STOMACH,FORESTOMACH | + | 7 | LYMPHOMA MALIGNANT | | 2| STOMACH,GLANDULAR | + | 7 | LYMPHOMA MALIGNANT | | 2| TONGUE | + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + | 7 | BLOOD VESSEL,AORTA | + | 7 | HEART | + | 8 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 82 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:41.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| S M| | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9| U O| 10MG FS-2YR 12 12 | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + | 9 | FIBROSARCOMA,METASTATIC,SKIN | | 1| ADRENAL GLAND,CORTEX | + | 8 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X | 3| ADRENAL GLAND,MEDULLA | + | 8 | ISLETS, PANCREATIC | + | 7 | LYMPHOMA MALIGNANT | | 1| PARATHYROID GLAND | M | 7 | PITUITARY GLAND | M | 4 | THYROID GLAND | + | 8 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + | 8 | LYMPHOMA MALIGNANT | | 1| OVARY | + + + + + + + + + + + + + + | 28 | CYSTADENOMA | | 1| LYMPHOMA MALIGNANT | | 2| SARCOMA | | 1| UTERUS | + + + + + + + + + + + + + + | 29 | LEIOMYOMA | | 1| LYMPHOMA MALIGNANT | | 1| VAGINA | + | 8 | LYMPHOMA MALIGNANT | | 3| ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + | 8 | LYMPHOMA MALIGNANT | X | 3| LYMPH NODE | + + + + + + | 15 | LYMPHOMA MALIGNANT,AXILLARY | | 1| LYMPHOMA MALIGNANT,INGUINAL | X | 2| LYMPHOMA MALIGNANT,MEDIASTINAL | X | 1| LYMPHOMA MALIGNANT,RENAL | X | 2| LYMPH NODE,MANDIBULAR | + + | 9 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 83 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:41.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| S M| | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9| U O| 10MG FS-2YR 12 12 | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT | X X | 4| LYMPH NODE,MESENTERIC | + + + + | 11 | LYMPHOMA MALIGNANT | X X X X | 6| SARCOMA | | 1| SPLEEN | + + + + + + | 20 | HEMANGIOSARCOMA | | 1| LYMPHOMA MALIGNANT | X X X X | 13| THYMUS | + | 6 | LYMPHOMA MALIGNANT | | 2| SARCOMA,METASTATIC,SKIN | | 1| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + | 6 | ADENOCARCINOMA | | 1| FIBROUS HISTIOCYTOMA | | 1| LYMPHOMA MALIGNANT | | 1| SKIN | + | 8 | FIBROSARCOMA | | 1| HEMANGIOSARCOMA,METASTATIC,UNCERTAIN PRIMA| | 1| RY SITE | | | LYMPHOMA MALIGNANT | | 1| SARCOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + | 8 | BONE,FEMUR | + | 8 | LYMPHOMA MALIGNANT | | 1| BONE,STERNUM | + | 8 | LYMPHOMA MALIGNANT | | 1| SKELETAL MUSCLE | + | 8 | LYMPHOMA MALIGNANT | | 2| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 84 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:41.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| S M| | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9| U O| 10MG FS-2YR 12 12 | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | NERVOUS SYSTEM BRAIN | + | 8 | BRAIN,CEREBELLUM | + | 8 | LYMPHOMA MALIGNANT | | 1| BRAIN,CEREBRUM | + | 8 | LYMPHOMA MALIGNANT | X | 2| PERIPHERAL NERVE | + | 8 | LYMPHOMA MALIGNANT | | 1| SPINAL CORD | + | 8 | SPINAL CORD,THORACIC | + | 8 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + | 4 | LUNG | + | 8 | FIBROUS HISTIOCYTOMA | | 1| LYMPHOMA MALIGNANT | X | 4| SARCOMA,METASTATIC,SKIN | | 1| NOSE | + | 8 | LYMPHOMA MALIGNANT | | 1| TRACHEA | + | 8 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + | 5 | HARDERIAN GLAND | + + | 10 | ADENOMA | X | 2| LYMPHOMA MALIGNANT | | 2| LACRIMAL GLAND | + | 5 | LYMPHOMA MALIGNANT | | 1| ZYMBAL'S GLAND | M | 6 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 85 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:41.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| S M| | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9| U O| 10MG FS-2YR 12 12 | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | URINARY SYSTEM KIDNEY | + + | 9 | LYMPHOMA MALIGNANT | X X | 5| URETER | + | 1 | LYMPHOMA MALIGNANT | X | 1| URINARY BLADDER | + | 8 | LYMPHOMA MALIGNANT | | 3| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 86 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:43.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| S M| | 0| 0| 0| 8| 8| 8| 9| 9| 9| 9| 9| 4| 4| 4| 4| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| U O| 25MG FS-2YR 13 13 | 8| 9| 7| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + M | | GALLBLADDER | + + + | | LYMPHOMA MALIGNANT | X | | INTESTINE LARGE | + + + | | INTESTINE LARGE,CECUM | + A A | | INTESTINE LARGE,COLON | + A + | | INTESTINE LARGE,RECTUM | + + M | | INTESTINE SMALL | + A A | | INTESTINE SMALL,DUODENUM | + A A | | INTESTINE SMALL,ILEUM | + A A | | INTESTINE SMALL,JEJUNUM | + A A | | LYMPHOMA MALIGNANT | | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | HEPATOCELLULAR ADENOMA | | | HEPATOCELLULAR ADENOMA,MULTIPLE | X | | LYMPHOMA MALIGNANT | X X X | | MESENTERY | | | HEMANGIOSARCOMA | | | PANCREAS | + + A | | LYMPHOMA MALIGNANT | X | | SALIVARY GLANDS | + + + | | STOMACH | + A + | | STOMACH,FORESTOMACH | + A + | | STOMACH,GLANDULAR | + A + | | LYMPHOMA MALIGNANT | X | | TONGUE | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + | | BLOOD VESSEL,AORTA | + + + | | HEART | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 87 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:43.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| S M| | 0| 0| 0| 8| 8| 8| 9| 9| 9| 9| 9| 4| 4| 4| 4| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| U O| 25MG FS-2YR 13 13 | 8| 9| 7| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + M | | ADRENAL GLAND,CORTEX | + + M | | ADRENAL GLAND,MEDULLA | + + M | | ISLETS, PANCREATIC | + + A + | | ADENOMA | X | | LYMPHOMA MALIGNANT | X | | PARATHYROID GLAND | M M M | | PITUITARY GLAND | M M M | | THYROID GLAND | + + M | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + M M | | OVARY | + + M + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | UTERUS | + + + + + + + + + + + + + + + | | FIBROSARCOMA | X | | VAGINA | + M M | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + A A | | LYMPHOMA MALIGNANT | X | | LYMPH NODE | + + + + + | | FIBROSARCOMA,METASTATIC,UTERUS,RENAL | X | | LYMPHOMA MALIGNANT,INGUINAL | X | | LYMPHOMA MALIGNANT,LUMBAR | | | LYMPHOMA MALIGNANT,RENAL | | | LYMPH NODE,MANDIBULAR | + + + | | LYMPHOMA MALIGNANT | X | | LYMPH NODE,MESENTERIC | + + M + | | LYMPHOMA MALIGNANT | X X | | SPLEEN | + + + + + + | | HEMANGIOSARCOMA | | | LYMPHOMA MALIGNANT | X X X | | THYMUS | + + M + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 88 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:43.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| S M| | 0| 0| 0| 8| 8| 8| 9| 9| 9| 9| 9| 4| 4| 4| 4| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| U O| 25MG FS-2YR 13 13 | 8| 9| 7| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + M | | SKIN | + + + | | FIBROSARCOMA | | | HEMANGIOSARCOMA | | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + | | BONE,FEMUR | + M + | | BONE,STERNUM | + + + | | SKELETAL MUSCLE | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + | | BRAIN,CEREBELLUM | + + + | | BRAIN,CEREBRUM | + + + | | PERIPHERAL NERVE | + + + | | SPINAL CORD | + + + | | SPINAL CORD,THORACIC | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + M | | LUNG | + + + | | ALVEOLAR/BRONCHIOLAR CARCINOMA | | | LYMPHOMA MALIGNANT | X | | NOSE | + + + | | TRACHEA | + + M | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 89 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:43.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 7| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| S M| | 0| 0| 0| 8| 8| 8| 9| 9| 9| 9| 9| 4| 4| 4| 4| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| U O| 25MG FS-2YR 13 13 | 8| 9| 7| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | A A A | | HARDERIAN GLAND | + + + + | | ADENOMA | X | | LACRIMAL GLAND | + + M | | ZYMBAL'S GLAND | M M + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + | | LYMPHOMA MALIGNANT | X | | URINARY BLADDER | + + M | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 90 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:43.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| S M| | 7| 0| 0| 0| 0| 0| 0| 0| 0| 6| 6| 6| 6| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2| U O| 25MG FS-2YR 13 13 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | | 2 | GALLBLADDER | | 3 | LYMPHOMA MALIGNANT | | 1| INTESTINE LARGE | | 3 | INTESTINE LARGE,CECUM | | 1 | INTESTINE LARGE,COLON | | 2 | INTESTINE LARGE,RECTUM | | 2 | INTESTINE SMALL | + | 2 | INTESTINE SMALL,DUODENUM | | 1 | INTESTINE SMALL,ILEUM | | 1 | INTESTINE SMALL,JEJUNUM | + | 2 | LYMPHOMA MALIGNANT | X | 1| LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA | | 1| HEPATOCELLULAR ADENOMA | X | 1| HEPATOCELLULAR ADENOMA,MULTIPLE | | 1| LYMPHOMA MALIGNANT | X | 4| MESENTERY | + | 1 | HEMANGIOSARCOMA | X | 1| PANCREAS | | 2 | LYMPHOMA MALIGNANT | | 1| SALIVARY GLANDS | | 3 | STOMACH | | 2 | STOMACH,FORESTOMACH | | 2 | STOMACH,GLANDULAR | | 2 | LYMPHOMA MALIGNANT | | 1| TONGUE | | 3 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | | 3 | BLOOD VESSEL,AORTA | | 3 | HEART | | 3 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 91 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:44.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| S M| | 7| 0| 0| 0| 0| 0| 0| 0| 0| 6| 6| 6| 6| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2| U O| 25MG FS-2YR 13 13 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | | 2 | ADRENAL GLAND,CORTEX | | 2 | ADRENAL GLAND,MEDULLA | | 2 | ISLETS, PANCREATIC | | 3 | ADENOMA | | 1| LYMPHOMA MALIGNANT | | 1| PARATHYROID GLAND | | 0 | PITUITARY GLAND | | 0 | THYROID GLAND | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | | 1 | OVARY | + + + + + + + + + + + + | 28 | LYMPHOMA MALIGNANT | | 1| UTERUS | + + + + + + + + + + + + + | 28 | FIBROSARCOMA | | 1| VAGINA | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | | 1 | LYMPHOMA MALIGNANT | | 1| LYMPH NODE | + | 6 | FIBROSARCOMA,METASTATIC,UTERUS,RENAL | | 1| LYMPHOMA MALIGNANT,INGUINAL | | 1| LYMPHOMA MALIGNANT,LUMBAR | X | 1| LYMPHOMA MALIGNANT,RENAL | X | 1| LYMPH NODE,MANDIBULAR | + | 4 | LYMPHOMA MALIGNANT | X | 2| LYMPH NODE,MESENTERIC | + | 4 | LYMPHOMA MALIGNANT | X | 3| SPLEEN | + + + + + + + + + | 15 | HEMANGIOSARCOMA | X X | 2| LYMPHOMA MALIGNANT | X X | 5| THYMUS | + | 4 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 92 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:44.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| S M| | 7| 0| 0| 0| 0| 0| 0| 0| 0| 6| 6| 6| 6| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2| U O| 25MG FS-2YR 13 13 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT | X | 3| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | | 2 | SKIN | + + + | 6 | FIBROSARCOMA | X | 1| HEMANGIOSARCOMA | X X | 2| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | | 3 | BONE,FEMUR | | 2 | BONE,STERNUM | | 3 | SKELETAL MUSCLE | | 3 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | | 3 | BRAIN,CEREBELLUM | | 3 | BRAIN,CEREBRUM | | 3 | PERIPHERAL NERVE | | 3 | SPINAL CORD | | 3 | SPINAL CORD,THORACIC | | 3 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | | 2 | LUNG | + | 4 | ALVEOLAR/BRONCHIOLAR CARCINOMA | X | 1| LYMPHOMA MALIGNANT | | 1| NOSE | | 3 | TRACHEA | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 93 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:44.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| S M| | 7| 0| 0| 0| 0| 0| 0| 0| 0| 6| 6| 6| 6| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2| U O| 25MG FS-2YR 13 13 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | | 0 | HARDERIAN GLAND | + | 5 | ADENOMA | | 1| LACRIMAL GLAND | | 2 | ZYMBAL'S GLAND | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | | 3 | LYMPHOMA MALIGNANT | | 1| URINARY BLADDER | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 94 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:50.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| S M| | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6| U O| 50MG FS-2YR 14 14 | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + M + + + + + + | | GALLBLADDER | M + + A + + A + + + + + + + + + + + + + + + + + + | | INTESTINE LARGE | A + + A + + A + + + + + + + + A + + + + + + + + + | | INTESTINE LARGE,CECUM | A + + A + + A + + + + + + + + A + + + + + + + + + | | LYMPHOMA MALIGNANT | | | INTESTINE LARGE,COLON | A + + A + + A + + + + + + + + A + + + + + + + + + | | INTESTINE LARGE,RECTUM | A + + A + + A + + + + + + + + A + + + + + + + + + | | INTESTINE SMALL | A + + A + + A + + + + + + + + A + + + + + + + + + | | INTESTINE SMALL,DUODENUM | A + + A M A A + + + + + + + + A + + + + + + + + + | | LYMPHOMA MALIGNANT | | | INTESTINE SMALL,ILEUM | A + + A + A A + + + + + + + + A + + + + + + + + + | | LYMPHOMA MALIGNANT | | | INTESTINE SMALL,JEJUNUM | A + + A + + A + + + + + + + + A + + + + + + + + + | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | X | | LYMPHOMA MALIGNANT | X X X | | PANCREAS | A + + + + + A + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | STOMACH | A + + A + + A + + + + + + + + A + + + + + + + + + | | STOMACH,FORESTOMACH | A + + A + + A + + + + + + + + A + + + + + + + + + | | STOMACH,GLANDULAR | A + + A + + A + + + + + + + + A + + + + + + + + + | | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + M M + + + + + + + + M + + M + + + + + M + + + | | BLOOD VESSEL,AORTA | + + M M + + + + + + + + M + + M + + + + + M + + + | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + + M + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 95 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:51.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| S M| | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6| U O| 50MG FS-2YR 14 14 | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ISLETS, PANCREATIC | A + + A + + A + + + + + + + + + + + + + + + + + + | | PARATHYROID GLAND | + M + + + + + + + + + + + + + + + + + + + + M + M | | PITUITARY GLAND | + + M + + + + + + + + + + + + + + + + + M + + + + | | ADENOMA,PARS DISTALIS | X | | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + + + M + + M + + M M + M M + + + + + + + + + | | OVARY | + + + + + + + + + + + + + + + M + + + M + + + + + | | CYSTADENOMA | | | GRANULOSA CELL TUMOR BENIGN | | | HEMANGIOSARCOMA,PERIOVARIAN TISSUE | X | | LUTEOMA | | | LYMPHOMA MALIGNANT | | | YOLK SAC CARCINOMA | X | | UTERUS | + + + A + + + + + + + + + + + + + + + + + + + + + | | VAGINA | A + + + + + + + + + + + + + + + + + + M + + + + + | | FIBROSARCOMA | | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + A + + + + + + + + + + + A + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LYMPHOMA MALIGNANT,RENAL | X | | LYMPHOMA MALIGNANT,THORACIC | X | | LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X X | | LYMPH NODE,MESENTERIC | + M + + + + + + + + + + + + + + + + + + + + + + M | | LYMPHOMA MALIGNANT | X X | | SPLEEN | A + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | LYMPHOMA MALIGNANT | X X X | | THYMUS | M + + M + + M + + + + + + M + M + + + + + M + + + | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 96 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:51.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| S M| | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6| U O| 50MG FS-2YR 14 14 | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + + + + + + + + A + + + + + + + + + | | ADENOCARCINOMA | | | ADENOMA | X | | SKIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + A + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | + + + A + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + A + + + + + + + + + + + + + + + + + + + + + | | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA | | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | M + + M + + + + + + + + + + + + + M + M + + + + + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X | | HEMANGIOSARCOMA | X | | LYMPHOMA MALIGNANT | X X | | YOLK SAC CARCINOMA,METASTATIC,OVARY | X | | NOSE | + + + A + + + + + + + + + + + + + + + + + + + + + | | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 97 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:51.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| S M| | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6| U O| 50MG FS-2YR 14 14 | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | A + + A + + + + + + + + + + + + + + + + + + + + + | | HARDERIAN GLAND | + + + + + + + M + + + + + + + + + + + + + + + + + | | ADENOMA | | | LACRIMAL GLAND | + + + + M + + + + + + + M + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | ZYMBAL'S GLAND | + + M + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | URINARY BLADDER | A + + + + + + + + + + + + + + A + + + + + + M + + | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 98 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:57.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| S M| | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2| U O| 50MG FS-2YR 14 14 | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + M + + + + + + + + + + + + + | 46 | GALLBLADDER | + + + + + + + + + + + + + + + + M + + + + + + | 44 | INTESTINE LARGE | + + + + + + + + + + + + + + + + + + + + + + + | 44 | INTESTINE LARGE,CECUM | + + + + + + + + + + + + + + + + + + + + + + | 43 | LYMPHOMA MALIGNANT | X | 1| INTESTINE LARGE,COLON | + + + + + + + + + + + + + + + + + + + + + + | 43 | INTESTINE LARGE,RECTUM | + + + + + + + + + + + + + + + + + + + + + + | 43 | INTESTINE SMALL | + + + + + + + + + + + + + + + + + + + + + + + | 44 | INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + + + + + + + + + + M | 41 | LYMPHOMA MALIGNANT | X | 1| INTESTINE SMALL,ILEUM | + + + + + + + + + + + + + + + + + + + + + + + | 43 | LYMPHOMA MALIGNANT | X X | 2| INTESTINE SMALL,JEJUNUM | + + + + + + + + + + + + + + + + + + + + + + + | 44 | LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA | X | 2| LYMPHOMA MALIGNANT | X X X X X X | 9| PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | X X | 2| SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X X | 2| STOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 44 | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 44 | STOMACH,GLANDULAR | + + + + + + + + + + + + + + + + + + + + + + + | 44 | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + | 43 | BLOOD VESSEL,AORTA | + + + + + + + + + + + + + + + + + + + + + + + | 43 | HEART | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + M + + + + + + + + + + + + M + + + + | 46 | ADRENAL GLAND,CORTEX | + + + + + M + + + + + + + + + + + + M + + + + | 46 | LYMPHOMA MALIGNANT | X | 2| ADRENAL GLAND,MEDULLA | + + + + + M + + + + + + + + + + + + M + + + + | 44 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 99 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:57.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| S M| | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2| U O| 50MG FS-2YR 14 14 | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + | 45 | PARATHYROID GLAND | + + + + + + + + + M + + + + + + + + + + + + + | 44 | PITUITARY GLAND | + + + + + + M + + + + M + M + M + + + + + + + | 42 | ADENOMA,PARS DISTALIS | | 1| THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + + + + + + + + M + + + M + M + + M M + + | 37 | OVARY | + + + + + + + + M + + + + + + + + + + + + + + | 45 | CYSTADENOMA | X | 1| GRANULOSA CELL TUMOR BENIGN | X | 1| HEMANGIOSARCOMA,PERIOVARIAN TISSUE | | 1| LUTEOMA | X | 1| LYMPHOMA MALIGNANT | X | 1| YOLK SAC CARCINOMA | | 1| UTERUS | + + + + + + + + + + + + + + + + + + + + + + + | 47 | VAGINA | + + + + + + + + + + + + + + + + + + + + + + + | 46 | FIBROSARCOMA | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | X | 2| LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 1| LYMPHOMA MALIGNANT,RENAL | X | 2| LYMPHOMA MALIGNANT,THORACIC | | 1| LYMPH NODE,MANDIBULAR | + M + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X X X | 7| LYMPH NODE,MESENTERIC | + + + + + + + + + + M + + M + + + + + + M + + | 43 | LYMPHOMA MALIGNANT | X X X X | 6| SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + | 46 | HEMANGIOSARCOMA | | 1| LYMPHOMA MALIGNANT | X X X X X X X X X X X | 14| THYMUS | + + + + + M M + M M + + + + M + + + + + + + + | 37 | LYMPHOMA MALIGNANT | X X | 2| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 100 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:57.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| S M| | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2| U O| 50MG FS-2YR 14 14 | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ADENOCARCINOMA | X | 1| ADENOMA | | 1| SKIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | FIBROSARCOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + | 47 | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + | 47 | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | FIBROSARCOMA | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + M + + + + M + + + + + + + + + + + + + | 42 | LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR ADENOMA | X X | 5| HEMANGIOSARCOMA | | 1| LYMPHOMA MALIGNANT | X X | 4| YOLK SAC CARCINOMA,METASTATIC,OVARY | | 1| NOSE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 101 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:21:57.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| S M| | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2| U O| 50MG FS-2YR 14 14 | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + | 46 | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ADENOMA | X | 1| LACRIMAL GLAND | + + + + + + + + M + + + + + M + + M + + + + + | 43 | LYMPHOMA MALIGNANT | X | 1| ZYMBAL'S GLAND | + + + + M + + + + + + + + M + + + + + + + + + | 45 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X X | 2| URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + | 45 | LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 102 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:04.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6| | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5| | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| S M| | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9| U O| CONTRL FS-2YR 19 19 | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | A + + + + + + + + + + + + + + + + + + + + M + + + | | GALLBLADDER | M + + + + + + M M + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | INTESTINE LARGE | A + + + + + + + + + + + + + + + + + + + + M A + + | | INTESTINE LARGE,CECUM | A + + + + + + + + + + + + + + + + + + + + M A + + | | INTESTINE LARGE,COLON | A + + + + + + + + + + + + + + + + + + + + M A + + | | INTESTINE LARGE,RECTUM | A + + + + + + + + + + + + + + + + + + + + M A + + | | INTESTINE SMALL | A + + + + + + + + + + + + + + + + + + + + + A + + | | INTESTINE SMALL,DUODENUM | A + + + + + + + + + + + + + + + + + + + + + A + + | | INTESTINE SMALL,ILEUM | A + + + + + + + M + M + + + + + + + + + + + A + + | | INTESTINE SMALL,JEJUNUM | A + + + + + + + M + + + + + + + + + + + + + A + + | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X X X | | MESENTERY | + | | PANCREAS | A + + + + + + + + + + + + + + + + + + + + + A + + | | LYMPHOMA MALIGNANT | X X X | | SALIVARY GLANDS | A + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | STOMACH | A + + + + + + + + + + + + + + + + + + + + + A + + | | STOMACH,FORESTOMACH | A + + + + + + + + + + + + + + + + + + + + + A + + | | STOMACH,GLANDULAR | A + + + + + + + + + + + + + + + + + + + + + A + + | | TONGUE | A + + + A + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | M + M M + + + + + + + + + + + + + + M + + + + + + | | BLOOD VESSEL,AORTA | M + M M + + + + + + + + + + + + + + M + + + + + + | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | A + + + + + + + + + + + + + + + + + + + + + + + + | | ADRENAL GLAND,CORTEX | A + + + + + + + + + + + + + + + + + + + + + + + + | | ADRENAL GLAND,MEDULLA | A + + + + + + + + + + + + + + + + + + + + + + + + | | ISLETS, PANCREATIC | A + + + + + + + + + + + + + + + + + + + + + A + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 103 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:04.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6| | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5| | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| S M| | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9| U O| CONTRL FS-2YR 19 19 | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM PARATHYROID GLAND | A + + + + + + + M + + + + + + + + + + + + M + + + | | LYMPHOMA MALIGNANT | X | | PITUITARY GLAND | A + + + + + + + + + + + + + + + + + + + + M M + + | | ADENOMA,PARS DISTALIS | | | ADENOMA,PARS INTERMEDIA | X | | THYROID GLAND | A + + + + + + + + + + + + + + + + + + + + M + + + | | ADENOMA,FOLLICULAR CELL | | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | A + + + + + + + + + + M + M + + + + M M + M M + + | | OVARY | A + + + + + + + + + + + + + + + + + + + + + A + + | | GRANULOSA CELL TUMOR BENIGN | | | LUTEOMA | | | LYMPHOMA MALIGNANT | X X | | LYMPHOMA MALIGNANT,PERIOVARIAN TISSUE | X | | UTERUS | + + + + + + + + + + + + + + + + + + + + + + A + + | | HISTIOCYTIC SARCOMA | X | | LEIOMYOMA | X | | LYMPHOMA MALIGNANT | X | | VAGINA | A + + M + + + + + + + + + + + + + + + + + + A + + | | FIBROSARCOMA | | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | A + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | LYMPH NODE | A + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT,INGUINAL | | | LYMPHOMA MALIGNANT,PANCREATIC | | | LYMPH NODE,MANDIBULAR | A + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | LYMPH NODE,MESENTERIC | A + + + + + + + + + + + + + + + + + + + + + M + + | | LYMPHOMA MALIGNANT | X X X X X | | SPLEEN | A + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X X X X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 104 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:05.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6| | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5| | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| S M| | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9| U O| CONTRL FS-2YR 19 19 | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM THYMUS | M + + M M + + + + + + + + + + M + + M + + + M + + | | LYMPHOMA MALIGNANT | X X X X X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | A + + + + + + + + + + + + + + + M M + + + M A + + | | ADENOCARCINOMA | X | | SKIN | A + + + + + + + + + + + + + + + + + + + + + A + + | | HEMANGIOMA | | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | A + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | A + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | A + + M + + + + + + + + + + + + + + + + + M + + + | | SKELETAL MUSCLE | A + + + A + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | PERIPHERAL NERVE | A + + + A + + + + + + + + + + + + + + M + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | A + + M + + + + + + + + + + + + + + + + + M M M + | | LUNG | A + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X | | ALVEOLAR/BRONCHIOLAR ADENOMA,MULTIPLE | | | LYMPHOMA MALIGNANT | X X X X | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TRACHEA | A + + + + + + + + + + + + + + + + + + + + M + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 105 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:05.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6| | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5| | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| S M| | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9| U O| CONTRL FS-2YR 19 19 | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | A + + + A + + + + + + + + + + + + + + + + + A + + | | HARDERIAN GLAND | A + + + A + + + + + + + + + + + + M + + + + M + + | | ADENOMA | | | LYMPHOMA MALIGNANT | X | | LACRIMAL GLAND | A + + M + + + + + + + + + + + M + + + + + M M + + | | LYMPHOMA MALIGNANT | X | | ZYMBAL'S GLAND | A + M M + + + + + + + + + + M + + M + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | A + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X X | | URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + M A + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 106 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:11.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| S M| | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5| U O| CONTRL FS-2YR 19 19 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + M + | 45 | GALLBLADDER | A + + + + + M + M + + + + M + + + + + + + + + | 41 | LYMPHOMA MALIGNANT | X | 3| INTESTINE LARGE | + + A + + + + + + + + + + + + + + + + + + + + | 44 | INTESTINE LARGE,CECUM | + A A + + + + + + + + + + + + + + + + + + + + | 43 | INTESTINE LARGE,COLON | + + A + + + + + + + + + + + + + + + + + + + + | 44 | INTESTINE LARGE,RECTUM | + + A + + + + + + + + + + + + + + + + + + + + | 44 | INTESTINE SMALL | A A A + + + + + + + + + + + + + + + + + + + + | 43 | INTESTINE SMALL,DUODENUM | A A A + + + + + + + + + + + + + + + + + + + + | 43 | INTESTINE SMALL,ILEUM | A A A + + + + M + + + + + + + + + + + + + + + | 40 | INTESTINE SMALL,JEJUNUM | A A A + + + + + + + M + + + + + + + + + + + + | 41 | LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA | X | 1| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X X X X | 9| MESENTERY | | 1 | PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | X X | 5| SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X X | 5| STOMACH | + + A + + + + + + + + + + + + + + + + + + + + | 45 | STOMACH,FORESTOMACH | + + A + + + + + + + + + + + + + + + + + + + + | 45 | STOMACH,GLANDULAR | + + A + + + + + + + + + + + + + + + + + + + + | 45 | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + | 46 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + M + M + M + + + + + + + + | 41 | BLOOD VESSEL,AORTA | + + + + + + + + + + M + M + M + + + + + + + + | 41 | HEART | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + | 46 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 107 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:11.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| S M| | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5| U O| CONTRL FS-2YR 19 19 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM PARATHYROID GLAND | + + + + + + + + + + + + + + + + + + + + + M + | 44 | LYMPHOMA MALIGNANT | X | 2| PITUITARY GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 45 | ADENOMA,PARS DISTALIS | X | 1| ADENOMA,PARS INTERMEDIA | | 1| THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 46 | ADENOMA,FOLLICULAR CELL | X | 1| LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | M + + + + + + + + + M + + + + M + + + + + + + | 38 | OVARY | + + + + + + + + + + + + + + + + + + + + + + + | 46 | GRANULOSA CELL TUMOR BENIGN | X | 1| LUTEOMA | X | 1| LYMPHOMA MALIGNANT | | 2| LYMPHOMA MALIGNANT,PERIOVARIAN TISSUE | X | 2| UTERUS | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HISTIOCYTIC SARCOMA | | 1| LEIOMYOMA | | 1| LYMPHOMA MALIGNANT | | 1| VAGINA | + + + + + + + + + + + M + + + + + + + + + + + | 44 | FIBROSARCOMA | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X X | 4| LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT,INGUINAL | X | 1| LYMPHOMA MALIGNANT,PANCREATIC | X | 1| LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X X X X | 7| LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | X X X | 8| SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X X X X | 11| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 108 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:11.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| S M| | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5| U O| CONTRL FS-2YR 19 19 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM THYMUS | M M M + + + M + + + M + + + + + + + + M + + + | 36 | LYMPHOMA MALIGNANT | X X X | 8| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 43 | ADENOCARCINOMA | | 1| SKIN | + + + + + + + + + + + + + + + + + + + + + + + | 46 | HEMANGIOMA | X | 1| LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + | 47 | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + | 45 | SKELETAL MUSCLE | M + + + + + + + + + + + + + + + + + + + + + + | 45 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PERIPHERAL NERVE | M + + + + + + + + + + + + + + + + + + + + + + | 44 | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + M + + + + + + + + + + + + + + + + + + + + | 42 | LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ALVEOLAR/BRONCHIOLAR ADENOMA | X | 2| ALVEOLAR/BRONCHIOLAR ADENOMA,MULTIPLE | X | 1| LYMPHOMA MALIGNANT | X X | 6| NOSE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + | 46 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 109 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:11.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| S M| | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5| U O| CONTRL FS-2YR 19 19 | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | A A A + + + + + + + + + + + + + + + + + + + + | 42 | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 44 | ADENOMA | X | 1| LYMPHOMA MALIGNANT | X | 2| LACRIMAL GLAND | M + + + + + + + + + + M M M + + + + + + + M M | 37 | LYMPHOMA MALIGNANT | X | 2| ZYMBAL'S GLAND | + M + + + + + + + + + + + + + + + + + + M + + | 41 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X X X | 6| URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + | 46 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X | 3| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 110 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:13.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6| | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6| | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0| U O| 10MG FS-2YR 20 20 | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | A + M + M + | | GALLBLADDER | A + + M + + | | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER | X | | INTESTINE LARGE | A A + A + + | | INTESTINE LARGE,CECUM | M A + A A + | | INTESTINE LARGE,COLON | M A + A + + | | INTESTINE LARGE,RECTUM | A A + A + + | | INTESTINE SMALL | M A + A + + | | INTESTINE SMALL,DUODENUM | M A + A A + | | LYMPHOMA MALIGNANT | | | INTESTINE SMALL,ILEUM | M A + A A + | | INTESTINE SMALL,JEJUNUM | M A + A + + | | LYMPHOMA MALIGNANT | | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | X | | HEPATOCELLULAR CARCINOMA | X X | | HEPATOCHOLANGIOCARCINOMA | X | | HISTIOCYTIC SARCOMA | X X | | LYMPHOMA MALIGNANT | X | | PANCREAS | A A + A + A | | HISTIOCYTIC SARCOMA | X | | SALIVARY GLANDS | A + + + + + | | STOMACH | M A + A + + | | STOMACH,FORESTOMACH | M A + A + + | | STOMACH,GLANDULAR | M A + A + + | | TONGUE | + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + M M + M + | | BLOOD VESSEL,AORTA | + M M + M + | | HEART | + + + + + + | | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 111 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:14.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6| | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6| | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0| U O| 10MG FS-2YR 20 20 | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | A A + + + + | | ADRENAL GLAND,CORTEX | A A + + + + | | ADRENAL GLAND,MEDULLA | A A + M + + | | PHEOCHROMOCYTOMA BENIGN | | | ISLETS, PANCREATIC | A A + A + A | | HISTIOCYTIC SARCOMA | X | | PARATHYROID GLAND | A + M + M M | | PITUITARY GLAND | A M M + M + | | THYROID GLAND | A + M + M + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + + + + | | OVARY | A + + + + + + + + + + + + + | | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER | X | | HISTIOCYTIC SARCOMA | X X | | UTERUS | A + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | HISTIOCYTIC SARCOMA | X X | | VAGINA | A + + + + + | | HISTIOCYTIC SARCOMA | X X | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPH NODE | + + + + + + | | LYMPHOMA MALIGNANT | | | LYMPHOMA MALIGNANT,MEDIASTINAL | | | LYMPHOMA MALIGNANT,RENAL | | | LYMPHOMA MALIGNANT,THORACIC | | | LYMPH NODE,MANDIBULAR | A + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | | | LYMPH NODE,MESENTERIC | + A + A + + | | HISTIOCYTIC SARCOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 112 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:14.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6| | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6| | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0| U O| 10MG FS-2YR 20 20 | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT | X | | SPLEEN | M + + + + + + A + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X | | THYMUS | A + + M M + | | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER | X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | A + + + + + M | | ADENOCARCINOMA | X | | SKIN | A + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + | | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER,| X | | MANDIBLE | | | BONE,FEMUR | + + + + + + | | BONE,STERNUM | + + + + + + | | SKELETAL MUSCLE | + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + | | BRAIN,CEREBELLUM | + + + + + + | | BRAIN,CEREBRUM | + + + + + + | | PERIPHERAL NERVE | + + + + + + | | SPINAL CORD | + + + + + + | | SPINAL CORD,THORACIC | + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | A + M M M + | | LUNG | A + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | | | ALVEOLAR/BRONCHIOLAR CARCINOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 113 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:14.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6| | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6| | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0| U O| 10MG FS-2YR 20 20 | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X | | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER | X | | HISTIOCYTIC SARCOMA | X | | NOSE | + + + + + + | | HISTIOCYTIC SARCOMA | X | | TRACHEA | A + M + M + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | A A + A A A | | HARDERIAN GLAND | + + + + + M | | LACRIMAL GLAND | A + + + M + | | ZYMBAL'S GLAND | + + + M + M | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | A + + + + + | | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER | X | | HISTIOCYTIC SARCOMA | X | | URINARY BLADDER | A A + A + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 114 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:15.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| S M| | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6| U O| 10MG FS-2YR 20 20 | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + | 5 | GALLBLADDER | + + | 6 | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER | | 1| INTESTINE LARGE | + + | 5 | INTESTINE LARGE,CECUM | + + | 4 | INTESTINE LARGE,COLON | + + | 5 | INTESTINE LARGE,RECTUM | + + | 5 | INTESTINE SMALL | + + + + | 7 | INTESTINE SMALL,DUODENUM | + + + | 5 | LYMPHOMA MALIGNANT | X | 1| INTESTINE SMALL,ILEUM | + + | 4 | INTESTINE SMALL,JEJUNUM | + + + + | 7 | LYMPHOMA MALIGNANT | X X | 2| LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA | | 1| HEPATOCELLULAR CARCINOMA | | 2| HEPATOCHOLANGIOCARCINOMA | | 1| HISTIOCYTIC SARCOMA | | 2| LYMPHOMA MALIGNANT | X X X | 4| PANCREAS | + + + | 5 | HISTIOCYTIC SARCOMA | | 1| SALIVARY GLANDS | + + | 7 | STOMACH | + + | 5 | STOMACH,FORESTOMACH | + + | 5 | STOMACH,GLANDULAR | + + | 5 | TONGUE | + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + | 5 | BLOOD VESSEL,AORTA | + + | 5 | HEART | + + | 8 | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 115 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:15.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| S M| | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6| U O| 10MG FS-2YR 20 20 | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + | 7 | ADRENAL GLAND,CORTEX | + + | 6 | ADRENAL GLAND,MEDULLA | + + + | 6 | PHEOCHROMOCYTOMA BENIGN | X | 1| ISLETS, PANCREATIC | + + | 4 | HISTIOCYTIC SARCOMA | | 1| PARATHYROID GLAND | + M | 3 | PITUITARY GLAND | + + | 4 | THYROID GLAND | + + | 5 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + M | 7 | OVARY | + + + + + + + + + | 22 | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER | | 1| HISTIOCYTIC SARCOMA | | 2| UTERUS | + + + + + + + + + + + + | 30 | HEMANGIOSARCOMA | | 1| HISTIOCYTIC SARCOMA | | 2| VAGINA | + + | 7 | HISTIOCYTIC SARCOMA | | 2| ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + | 8 | HISTIOCYTIC SARCOMA | | 1| LYMPH NODE | + + + + + + + | 13 | LYMPHOMA MALIGNANT | X | 1| LYMPHOMA MALIGNANT,MEDIASTINAL | X X | 2| LYMPHOMA MALIGNANT,RENAL | X | 1| LYMPHOMA MALIGNANT,THORACIC | X | 1| LYMPH NODE,MANDIBULAR | + + + | 8 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X | 1| LYMPH NODE,MESENTERIC | + + + + + + | 10 | HISTIOCYTIC SARCOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 116 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:15.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| S M| | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6| U O| 10MG FS-2YR 20 20 | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT | X X X X | 5| SPLEEN | + + + + + + + + + + | 18 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X X X X X X | 8| THYMUS | + M | 4 | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER | | 1| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + M | 6 | ADENOCARCINOMA | | 1| SKIN | + + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + | 8 | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER,| | 1| MANDIBLE | | | BONE,FEMUR | + + | 8 | BONE,STERNUM | + + | 8 | SKELETAL MUSCLE | + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + | 8 | BRAIN,CEREBELLUM | + + | 8 | BRAIN,CEREBRUM | + + | 8 | PERIPHERAL NERVE | + + | 8 | SPINAL CORD | + + | 8 | SPINAL CORD,THORACIC | + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + | 4 | LUNG | + + | 8 | ALVEOLAR/BRONCHIOLAR ADENOMA | X | 1| ALVEOLAR/BRONCHIOLAR CARCINOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 117 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:15.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| S M| | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6| U O| 10MG FS-2YR 20 20 | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | | 1| HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER | | 1| HISTIOCYTIC SARCOMA | | 1| NOSE | + + | 8 | HISTIOCYTIC SARCOMA | | 1| TRACHEA | + M | 4 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + | 3 | HARDERIAN GLAND | + + | 7 | LACRIMAL GLAND | + + | 6 | ZYMBAL'S GLAND | + + | 6 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + | 8 | HEPATOCHOLANGIOCARCINOMA,METASTATIC,LIVER | | 1| HISTIOCYTIC SARCOMA | | 1| URINARY BLADDER | + + | 5 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 118 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:18.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0| | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| S M| | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1| U O| 25MG FS-2YR 21 21 | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + | | GALLBLADDER | + + + + + + + + | | INTESTINE LARGE | + + + + + + + + | | INTESTINE LARGE,CECUM | + + + + + + A + | | INTESTINE LARGE,COLON | + + + + + + + + | | INTESTINE LARGE,RECTUM | + + + + + + + + | | INTESTINE SMALL | + + + + + + + + | | INTESTINE SMALL,DUODENUM | + + + + + + + A | | INTESTINE SMALL,ILEUM | + + + + + + A + | | INTESTINE SMALL,JEJUNUM | + + + + + + A + | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | HEPATOCELLULAR ADENOMA | X X | | HEPATOCELLULAR CARCINOMA | X | | HISTIOCYTIC SARCOMA | | | ITO CELL TUMOR NOS | | | LYMPHOMA MALIGNANT | X X | | PANCREAS | + + + + + + + + | | CARCINOMA,METASTATIC,UNCERTAIN PRIMARY SIT| X | | E | | | SALIVARY GLANDS | + + + + + + + + | | STOMACH | + + + + + + + + | | STOMACH,FORESTOMACH | + + + + + + + + | | STOMACH,GLANDULAR | + + + + + + + + | | TONGUE | + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | M M + + + + + + | | BLOOD VESSEL,AORTA | M M + + + + + + | | HEART | + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + | | ADRENAL GLAND,CORTEX | + + + + + + + + | | ADRENAL GLAND,MEDULLA | + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 119 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:18.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0| | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| S M| | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1| U O| 25MG FS-2YR 21 21 | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ISLETS, PANCREATIC | + + + + + + + + | | ADENOMA | | | PARATHYROID GLAND | + M + M + + M M | | PITUITARY GLAND | + + + + + + M + M | | ADENOMA,PARS DISTALIS | X | | THYROID GLAND | + + + + + + M + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + M + M + + + + | | OVARY | + + + + + + + + + + + + + + + M + | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | X | | UTERUS | + + + + + + + + + + + + + + + + + | | FIBROMA | | | HEMANGIOSARCOMA | X | | HISTIOCYTIC SARCOMA | | | VAGINA | + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + | | LYMPH NODE | + + + + + + + A + | | LYMPHOMA MALIGNANT,LUMBAR | X | | LYMPHOMA MALIGNANT,RENAL | | | LYMPH NODE,MANDIBULAR | + + + + + + A + | | SQUAMOUS CELL CARCINOMA,METASTATIC,NOSE | X | | LYMPH NODE,MESENTERIC | + + + M + + A + | | CARCINOMA,METASTATIC,UNCERTAIN PRIMARY SIT| X | | E | | | LYMPHOMA MALIGNANT | X | | SPLEEN | + + + + + + + + + + | | HEMANGIOSARCOMA | X | | LYMPHOMA MALIGNANT | X | | THYMUS | M M + + + + + M M + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 120 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:18.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0| | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| S M| | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1| U O| 25MG FS-2YR 21 21 | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT | X X X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + + | | ADENOCARCINOMA | X | | HISTIOCYTIC SARCOMA | X | | SKIN | + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + | | BONE,FEMUR | + + + + + + + + | | BONE,STERNUM | + + + + + + + + | | SKELETAL MUSCLE | + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + | | PERIPHERAL NERVE | + + + + + + + + | | SPINAL CORD | + + + + + + M + | | SPINAL CORD,THORACIC | + + + + + + M + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + M + + + + + | | LUNG | + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | | | ALVEOLAR/BRONCHIOLAR CARCINOMA,MULTIPLE | X | | CARCINOMA,METASTATIC,UNCERTAIN PRIMARY SIT| X | | E | | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X | | HISTIOCYTIC SARCOMA | X | | NOSE | + + + + + + + + | | SQUAMOUS CELL CARCINOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 121 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:18.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7| | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0| | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| S M| | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1| U O| 25MG FS-2YR 21 21 | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM TRACHEA | + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + A A + + + A A | | HARDERIAN GLAND | + + + + + + + + | | HISTIOCYTIC SARCOMA | | | LACRIMAL GLAND | + M + + + M + + | | ZYMBAL'S GLAND | M + + + + M + + | | SQUAMOUS CELL CARCINOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + | | CARCINOMA,METASTATIC,UNCERTAIN PRIMARY SIT| X | | E | | | LYMPHOMA MALIGNANT | X | | URINARY BLADDER | + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 122 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:19.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| S M| | 3| 3| 3| 6| 6| 6| 6| 8| 0| 0| 0| 3| 3| 5| 5| 8| 8| 8| 9| 5| 5| 5| 5| U O| 25MG FS-2YR 21 21 | 5| 6| 7| 2| 3| 4| 5| 6| 3| 4| 5| 6| 7| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + | 10 | GALLBLADDER | + M | 9 | INTESTINE LARGE | + A | 9 | INTESTINE LARGE,CECUM | + A | 8 | INTESTINE LARGE,COLON | + A | 9 | INTESTINE LARGE,RECTUM | + A | 9 | INTESTINE SMALL | + + A | 10 | INTESTINE SMALL,DUODENUM | + + A | 9 | INTESTINE SMALL,ILEUM | M A | 7 | INTESTINE SMALL,JEJUNUM | + A | 8 | LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA | | 1| HEPATOCELLULAR ADENOMA | | 2| HEPATOCELLULAR CARCINOMA | | 1| HISTIOCYTIC SARCOMA | X X | 2| ITO CELL TUMOR NOS | X | 1| LYMPHOMA MALIGNANT | X | 3| PANCREAS | + + | 10 | CARCINOMA,METASTATIC,UNCERTAIN PRIMARY SIT| | 1| E | | | SALIVARY GLANDS | + + | 10 | STOMACH | + A | 9 | STOMACH,FORESTOMACH | + A | 9 | STOMACH,GLANDULAR | + A | 9 | TONGUE | + + | 10 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + | 8 | BLOOD VESSEL,AORTA | + + | 8 | HEART | + + | 10 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + | 10 | ADRENAL GLAND,CORTEX | + + | 10 | ADRENAL GLAND,MEDULLA | + + | 10 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 123 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:19.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| S M| | 3| 3| 3| 6| 6| 6| 6| 8| 0| 0| 0| 3| 3| 5| 5| 8| 8| 8| 9| 5| 5| 5| 5| U O| 25MG FS-2YR 21 21 | 5| 6| 7| 2| 3| 4| 5| 6| 3| 4| 5| 6| 7| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ISLETS, PANCREATIC | + + + | 11 | ADENOMA | X | 1| PARATHYROID GLAND | + M | 5 | PITUITARY GLAND | + + | 9 | ADENOMA,PARS DISTALIS | | 1| THYROID GLAND | + + | 9 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + | 8 | OVARY | + + + + + + + + + + + + + + | 30 | HISTIOCYTIC SARCOMA | X X | 2| LYMPHOMA MALIGNANT | | 1| UTERUS | + + + + + + + + + + + + + + + + + + | 35 | FIBROMA | X | 1| HEMANGIOSARCOMA | | 1| HISTIOCYTIC SARCOMA | X X X | 3| VAGINA | + + | 10 | HISTIOCYTIC SARCOMA | X X | 3| LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + | 10 | LYMPH NODE | + + + | 11 | LYMPHOMA MALIGNANT,LUMBAR | | 1| LYMPHOMA MALIGNANT,RENAL | X | 1| LYMPH NODE,MANDIBULAR | + + | 9 | SQUAMOUS CELL CARCINOMA,METASTATIC,NOSE | | 1| LYMPH NODE,MESENTERIC | + + | 8 | CARCINOMA,METASTATIC,UNCERTAIN PRIMARY SIT| | 1| E | | | LYMPHOMA MALIGNANT | | 1| SPLEEN | + + + + + + + | 17 | HEMANGIOSARCOMA | | 1| LYMPHOMA MALIGNANT | X | 2| THYMUS | M + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 124 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:19.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| S M| | 3| 3| 3| 6| 6| 6| 6| 8| 0| 0| 0| 3| 3| 5| 5| 8| 8| 8| 9| 5| 5| 5| 5| U O| 25MG FS-2YR 21 21 | 5| 6| 7| 2| 3| 4| 5| 6| 3| 4| 5| 6| 7| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT | | 3| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + M | 11 | ADENOCARCINOMA | X | 2| HISTIOCYTIC SARCOMA | | 1| SKIN | + + | 10 | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + | 10 | BONE,FEMUR | + + | 10 | BONE,STERNUM | + + | 10 | SKELETAL MUSCLE | + + | 10 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + | 10 | BRAIN,CEREBELLUM | + + | 10 | BRAIN,CEREBRUM | + + | 10 | PERIPHERAL NERVE | + + | 10 | SPINAL CORD | + + | 9 | SPINAL CORD,THORACIC | + + | 9 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + | 9 | LUNG | + + | 11 | ALVEOLAR/BRONCHIOLAR ADENOMA | X | 1| ALVEOLAR/BRONCHIOLAR CARCINOMA,MULTIPLE | | 1| CARCINOMA,METASTATIC,UNCERTAIN PRIMARY SIT| | 1| E | | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | | 1| HISTIOCYTIC SARCOMA | X | 2| NOSE | + + | 10 | SQUAMOUS CELL CARCINOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 125 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:19.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 3| 3| 3| 3| 4| 2| 2| 2| 3| 3| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| S M| | 3| 3| 3| 6| 6| 6| 6| 8| 0| 0| 0| 3| 3| 5| 5| 8| 8| 8| 9| 5| 5| 5| 5| U O| 25MG FS-2YR 21 21 | 5| 6| 7| 2| 3| 4| 5| 6| 3| 4| 5| 6| 7| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM TRACHEA | + + | 10 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | A + A | 5 | HARDERIAN GLAND | + + | 10 | HISTIOCYTIC SARCOMA | X | 1| LACRIMAL GLAND | M + | 7 | ZYMBAL'S GLAND | + + | 8 | SQUAMOUS CELL CARCINOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + | 10 | CARCINOMA,METASTATIC,UNCERTAIN PRIMARY SIT| | 1| E | | | LYMPHOMA MALIGNANT | | 1| URINARY BLADDER | + + | 10 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 126 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:26.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 6| 7| 7| | 1| 7| 7| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 8| 8| 9| 4| 4| | 7| 5| 6| 5| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 7| 4| 4| 3| 3| 3| 1| 4| 7| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| S M| | 7| 8| 9| 0| 1| 1| 1| 4| 4| 4| 5| 7| 7| 7| 9| 0| 0| 4| 5| 5| 6| 7| 2| 4| 4| U O| 50MG FS-2YR 22 22 | 2| 9| 0| 3| 7| 8| 9| 7| 8| 9| 0| 7| 8| 9| 9| 7| 8| 9| 0| 1| 8| 1| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | M + + A + + + + + + + + + + + + + + + + + + + + + | | GALLBLADDER | + + + M + + + + + + + + + M + + + + + + + + + + + | | INTESTINE LARGE | A + + A + + + + + + + + + + A + + + + + + + + + + | | INTESTINE LARGE,CECUM | A + + A + + + + + + + + + + A + + + + + + + + + + | | INTESTINE LARGE,COLON | A + + A + + + + + + + + + + A + + + + + + + + + + | | INTESTINE LARGE,RECTUM | A + + A + + + + + + + + + + A + + + + + + + + + + | | INTESTINE SMALL | A + + A + + + + + + + + + + A + + + + + + + + + + | | INTESTINE SMALL,DUODENUM | A + + A + + + + + + + + + + A + + + + + + + + + + | | INTESTINE SMALL,ILEUM | A + + A + + + + + + + + + + A + + + + + + + + + + | | INTESTINE SMALL,JEJUNUM | A + + A + + + + + + + + + + A + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | | | HEPATOCELLULAR CARCINOMA | X | | LYMPHOMA MALIGNANT | X X | | MESENTERY | + | | PANCREAS | + + + A + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + + | | STOMACH | + + + A + + + + + + + + M + + + + + + + + + + + + | | STOMACH,FORESTOMACH | + + + A + + + + + + + + M + + + + + + + + + + + + | | STOMACH,GLANDULAR | + + + A + + + + + + + + M + + + + + + + + + + + + | | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | M M + + + + + + + + + + + + + + + + + + + + + + + | | BLOOD VESSEL,AORTA | M M + + + + + + + + + + + + + + + + + + + + + + + | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | ISLETS, PANCREATIC | + + + A + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 127 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:26.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 6| 7| 7| | 1| 7| 7| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 8| 8| 9| 4| 4| | 7| 5| 6| 5| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 7| 4| 4| 3| 3| 3| 1| 4| 7| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| S M| | 7| 8| 9| 0| 1| 1| 1| 4| 4| 4| 5| 7| 7| 7| 9| 0| 0| 4| 5| 5| 6| 7| 2| 4| 4| U O| 50MG FS-2YR 22 22 | 2| 9| 0| 3| 7| 8| 9| 7| 8| 9| 0| 7| 8| 9| 9| 7| 8| 9| 0| 1| 8| 1| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM PARATHYROID GLAND | M + + A + + + + + + + + + M + + + + + + + + + + + | | PITUITARY GLAND | M + + + + + + + + + + + + + + + + M + + + M + + M | | ADENOMA,PARS DISTALIS | X | | CARCINOMA,PARS DISTALIS | X | | THYROID GLAND | + + + A + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + + M + + + M + + + + + + + + M M + M M + M + | | OVARY | + + + + + + + + M + + + + + + + + + M + + + + + + | | UTERUS | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | POLYP | X | | VAGINA | + M + A + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA | | | POLYP | | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR CARCINOMA,METASTATIC,| X | | LUNG,MEDIASTINAL | | | LYMPHOMA MALIGNANT,LUMBAR | | | LYMPHOMA MALIGNANT,MEDIASTINAL | | | LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPH NODE,MESENTERIC | M + + A + + + + + + + + + + + + + + + + + + + M + | | LYMPHOMA MALIGNANT | | | SPLEEN | + + + A + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | LYMPHOMA MALIGNANT | X | | THYMUS | M M + + + + + M + + + + + + + + + + + + M M M + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 128 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:26.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 6| 7| 7| | 1| 7| 7| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 8| 8| 9| 4| 4| | 7| 5| 6| 5| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 7| 4| 4| 3| 3| 3| 1| 4| 7| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| S M| | 7| 8| 9| 0| 1| 1| 1| 4| 4| 4| 5| 7| 7| 7| 9| 0| 0| 4| 5| 5| 6| 7| 2| 4| 4| U O| 50MG FS-2YR 22 22 | 2| 9| 0| 3| 7| 8| 9| 7| 8| 9| 0| 7| 8| 9| 9| 7| 8| 9| 0| 1| 8| 1| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOCARCINOMA | X | | SKIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA,METASTATIC,SPLEEN | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + + + | | OSTEOSARCOMA,PELVIS | X | | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR CARCINOMA,METASTATIC,| X | | LUNG,ADVENTITIA | | | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + M + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | CARCINOMA,METASTATIC,PITUITARY GLAND | X | | PERIPHERAL NERVE | + + M + + + + + + + + + + + + + + + M + + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | M + + A + + + + + + + + + + + + + + + + M + + + + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X | | ALVEOLAR/BRONCHIOLAR CARCINOMA | X X | | CARCINOMA,METASTATIC,HARDERIAN GLAND | | | LYMPHOMA MALIGNANT | | | OSTEOSARCOMA,METASTATIC,BONE | X | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TRACHEA | + + + A + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 129 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:26.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 4| 6| 7| 7| | 1| 7| 7| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 8| 8| 9| 4| 4| | 7| 5| 6| 5| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 7| 4| 4| 3| 3| 3| 1| 4| 7| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| S M| | 7| 8| 9| 0| 1| 1| 1| 4| 4| 4| 5| 7| 7| 7| 9| 0| 0| 4| 5| 5| 6| 7| 2| 4| 4| U O| 50MG FS-2YR 22 22 | 2| 9| 0| 3| 7| 8| 9| 7| 8| 9| 0| 7| 8| 9| 9| 7| 8| 9| 0| 1| 8| 1| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | + + A A + + + + + + + + + + A + + + + + + + + + + | | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | X | | CARCINOMA | | | LACRIMAL GLAND | + + + + + + + + + + + + + + + + + + M + + + + + + | | ZYMBAL'S GLAND | + + + M + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 130 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:32.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| S M| | 4| 4| 6| 6| 6| 0| 1| 1| 1| 4| 4| 5| 6| 6| 6| 9| 9| 9| 9| 5| 5| 6| 6| U O| 50MG FS-2YR 22 22 | 3| 4| 6| 7| 8| 9| 0| 1| 2| 1| 2| 9| 0| 1| 2| 5| 6| 7| 8| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + M + + + + + + + + + + + + + + | 45 | GALLBLADDER | + + + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE LARGE | + + + + + + + + + + + + + + + + + + + + + + + | 45 | INTESTINE LARGE,CECUM | + + + + + + + + + + + + + + + + + + + + + + + | 45 | INTESTINE LARGE,COLON | + + + + + + + + + + + + + + + + + + + + + + + | 45 | INTESTINE LARGE,RECTUM | + + + + + + + + + + + + + + + + + + + + + + + | 45 | INTESTINE SMALL | + + + + + + + + + + + + + + + + + + + + + + + | 45 | INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + + + + + + + M + + + | 44 | INTESTINE SMALL,ILEUM | + + + + + + + + + + + + + + + + + + + + + + + | 45 | INTESTINE SMALL,JEJUNUM | + + + + + + + + + + + + + + + + + + + + + + + | 45 | LYMPHOMA MALIGNANT | X | 1| LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA | X | 1| HEPATOCELLULAR CARCINOMA | | 1| LYMPHOMA MALIGNANT | X X X X | 6| MESENTERY | | 1 | PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X | 1| SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | STOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 46 | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 46 | STOMACH,GLANDULAR | + + + + + + + + + + + + + + + + + + + + + + + | 46 | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + | 46 | BLOOD VESSEL,AORTA | + + + + + + + + + + + + + + + + + + + + + + + | 46 | HEART | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + + + + + + + + M | 47 | LYMPHOMA MALIGNANT | X | 1| ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 131 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:32.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| S M| | 4| 4| 6| 6| 6| 0| 1| 1| 1| 4| 4| 5| 6| 6| 6| 9| 9| 9| 9| 5| 5| 6| 6| U O| 50MG FS-2YR 22 22 | 3| 4| 6| 7| 8| 9| 0| 1| 2| 1| 2| 9| 0| 1| 2| 5| 6| 7| 8| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM PARATHYROID GLAND | + + + + + + + M + + + + + + + + + M + + + + + | 43 | PITUITARY GLAND | + + + + + + + + + + + M + + + + + + + + + + + | 43 | ADENOMA,PARS DISTALIS | | 1| CARCINOMA,PARS DISTALIS | | 1| THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM CLITORAL GLAND | + + + + + + + M + + + + + M + + M M M M + + + | 35 | OVARY | + + + + + + + + + + + + + + + + + + + + + + + | 46 | UTERUS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA | X | 2| POLYP | | 1| VAGINA | + + + + + + + + + + + + + + + + + + + + + + + | 46 | FIBROSARCOMA | X | 1| POLYP | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR CARCINOMA,METASTATIC,| | 1| LUNG,MEDIASTINAL | | | LYMPHOMA MALIGNANT,LUMBAR | X | 1| LYMPHOMA MALIGNANT,MEDIASTINAL | X | 1| LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + | 45 | LYMPHOMA MALIGNANT | X | 1| SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HEMANGIOSARCOMA | X | 2| LYMPHOMA MALIGNANT | X X X X | 5| THYMUS | + + + M + + + + + + + + + + + M + + + + + + + | 40 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 132 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:32.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| S M| | 4| 4| 6| 6| 6| 0| 1| 1| 1| 4| 4| 5| 6| 6| 6| 9| 9| 9| 9| 5| 5| 6| 6| U O| 50MG FS-2YR 22 22 | 3| 4| 6| 7| 8| 9| 0| 1| 2| 1| 2| 9| 0| 1| 2| 5| 6| 7| 8| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + + + + + + + M + M + + + + + + | 46 | ADENOCARCINOMA | X X X X | 5| SKIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA,METASTATIC,SPLEEN | | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | OSTEOSARCOMA,PELVIS | | 1| BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR CARCINOMA,METASTATIC,| | 1| LUNG,ADVENTITIA | | | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | CARCINOMA,METASTATIC,PITUITARY GLAND | | 1| PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + | 46 | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + + + + + + + + + | 45 | LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR ADENOMA | | 1| ALVEOLAR/BRONCHIOLAR CARCINOMA | | 2| CARCINOMA,METASTATIC,HARDERIAN GLAND | X | 1| LYMPHOMA MALIGNANT | X | 1| OSTEOSARCOMA,METASTATIC,BONE | | 1| NOSE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | TRACHEA | + + + + + M M + + + + + + + + + + + + + + + + | 45 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 133 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:32.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| S M| | 4| 4| 6| 6| 6| 0| 1| 1| 1| 4| 4| 5| 6| 6| 6| 9| 9| 9| 9| 5| 5| 6| 6| U O| 50MG FS-2YR 22 22 | 3| 4| 6| 7| 8| 9| 0| 1| 2| 1| 2| 9| 0| 1| 2| 5| 6| 7| 8| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + | 45 | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ADENOMA | X X | 3| CARCINOMA | X | 1| LACRIMAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ZYMBAL'S GLAND | + + + + + + + + + + + + + + + + + + + + M + + | 46 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 2| URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 134 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:39.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| | 6| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 8| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 7| 1| 2| 2| 3| 3| 5| 5| 6| 6| 8| 8| 9| 9| 1| 1| 1| 2| 3| 5| 5| 5| 5| 6| 2| U O| CONTRL MS-2YR 27 27 | 0| 0| 8| 9| 0| 1| 8| 9| 0| 1| 8| 9| 0| 1| 7| 8| 9| 0| 3| 6| 7| 8| 9| 0| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + + + | | GALLBLADDER | + + + + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE LARGE | + + + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE LARGE,CECUM | + + + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE LARGE,COLON | + + + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE LARGE,RECTUM | + + + + + + + + + + + + + M + + + + + + + + + + A | | INTESTINE SMALL | + + + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE SMALL,ILEUM | + + + + + + + + + + + + + + + + + + + + + + + + A | | LYMPHOMA MALIGNANT | | | INTESTINE SMALL,JEJUNUM | + + + + + + + + + + + + + + + + + + + + + + + + A | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | HEPATOBLASTOMA | | | HEPATOCELLULAR ADENOMA | X X X X X X | | HEPATOCELLULAR ADENOMA,MULTIPLE | X | | HEPATOCELLULAR CARCINOMA | X X X X | | HEPATOCELLULAR CARCINOMA,MULTIPLE | | | HEPATOCHOLANGIOCARCINOMA | X | | HISTIOCYTIC SARCOMA | X X | | LYMPHOMA MALIGNANT | X X | | MESENTERY | + | | PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + + A | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + A | | STOMACH | + + + + + + + + + + + + + + + + + + + + + + + + + | | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | STOMACH,GLANDULAR | + + + + + + + + + + + + + + + + + + + + + + + + A | | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + + M | | BLOOD VESSEL,AORTA | + + + + + + + + + + + + + + + + + + + + + + + + M | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 135 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:39.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| | 6| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 8| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 7| 1| 2| 2| 3| 3| 5| 5| 6| 6| 8| 8| 9| 9| 1| 1| 1| 2| 3| 5| 5| 5| 5| 6| 2| U O| CONTRL MS-2YR 27 27 | 0| 0| 8| 9| 0| 1| 8| 9| 0| 1| 8| 9| 0| 1| 7| 8| 9| 0| 3| 6| 7| 8| 9| 0| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + M + + + + + + + + + | | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + + A | | PARATHYROID GLAND | + + + M + + + + + + + M + + + + + + + + + + M + M | | PITUITARY GLAND | M + + + + + + + + + + + + + + + + + + + I M + + M | | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | X X | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | EPIDIDYMIS | + + + + + + + + + + + + + + + + + + + + + + + + + | | PREPUTIAL GLAND | + + + + + + + + + + + + + + + + + M + + + + + + + | | PROSTATE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | SEMINAL VESICLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TESTES | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA,LUMBAR | X | | HISTIOCYTIC SARCOMA,RENAL | X | | LYMPHOMA MALIGNANT,RENAL | | | LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X | | LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + + A | | LYMPHOMA MALIGNANT | | | SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + + A | | HEMANGIOSARCOMA | X | | LYMPHOMA MALIGNANT | X X | | THYMUS | M M + + + + + + + + + M + + + M + + + + + M M + A | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 136 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:39.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| | 6| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 8| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 7| 1| 2| 2| 3| 3| 5| 5| 6| 6| 8| 8| 9| 9| 1| 1| 1| 2| 3| 5| 5| 5| 5| 6| 2| U O| CONTRL MS-2YR 27 27 | 0| 0| 8| 9| 0| 1| 8| 9| 0| 1| 8| 9| 0| 1| 7| 8| 9| 0| 3| 6| 7| 8| 9| 0| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | M + M M M M M M M M M M + M M M M M M M M M M M M | | SKIN | + + + + + + + + + + + + + + + + + + + + + + + + A | | FIBROSARCOMA | | | HEMANGIOSARCOMA | | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + A | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + A | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + A | | PERIPHERAL NERVE | + + + + + + M + + + + + + + + + + + + + + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + A | | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + + A | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | M + + + + + + + + + + + + + + + + + + + + + + + M | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X | | ALVEOLAR/BRONCHIOLAR CARCINOMA | X X X | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X | | HISTIOCYTIC SARCOMA | X | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 137 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:40.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| | 6| 0| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 8| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 7| 1| 2| 2| 3| 3| 5| 5| 6| 6| 8| 8| 9| 9| 1| 1| 1| 2| 3| 5| 5| 5| 5| 6| 2| U O| CONTRL MS-2YR 27 27 | 0| 0| 8| 9| 0| 1| 8| 9| 0| 1| 8| 9| 0| 1| 7| 8| 9| 0| 3| 6| 7| 8| 9| 0| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + + + | | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | X | | LACRIMAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ZYMBAL'S GLAND | + + + + + + + + + + + + + + + + + + M M M + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X | | URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 138 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:46.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 3| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| S M| | 5| 5| 5| 5| 7| 7| 7| 7| 2| 2| 2| 2| 4| 5| 5| 5| 1| 1| 1| 1| 1| 1| 1| U O| CONTRL MS-2YR 27 27 | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | GALLBLADDER | + + + + + + + + + + + + + + + M + + + + + + + | 47 | INTESTINE LARGE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | INTESTINE LARGE,CECUM | + + + + + + + + + + + + + + + + + + + + + + + | 47 | INTESTINE LARGE,COLON | + + + + + + + + + + + + + + + + + + + + + + + | 47 | INTESTINE LARGE,RECTUM | + + + + + + + + + + + + M + + + + + + + + + + | 45 | INTESTINE SMALL | + + + + + + + + + + + + + + + + + + + + + + + | 47 | INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + + + + + + + + + + + | 47 | INTESTINE SMALL,ILEUM | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X | 1| INTESTINE SMALL,JEJUNUM | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA | | 1| HEPATOBLASTOMA | X | 1| HEPATOCELLULAR ADENOMA | X X X X X X X X X X | 16| HEPATOCELLULAR ADENOMA,MULTIPLE | X | 2| HEPATOCELLULAR CARCINOMA | X X X X X | 9| HEPATOCELLULAR CARCINOMA,MULTIPLE | X | 1| HEPATOCHOLANGIOCARCINOMA | | 1| HISTIOCYTIC SARCOMA | | 2| LYMPHOMA MALIGNANT | X X | 4| MESENTERY | | 1 | PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + | 47 | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + | 47 | STOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 48 | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | | 1| STOMACH,GLANDULAR | + + + + + + + + + + + + + + + + + + + + + + + | 47 | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + | 47 | BLOOD VESSEL,AORTA | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HEART | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 139 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:46.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 3| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| S M| | 5| 5| 5| 5| 7| 7| 7| 7| 2| 2| 2| 2| 4| 5| 5| 5| 1| 1| 1| 1| 1| 1| 1| U O| CONTRL MS-2YR 27 27 | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + | 47 | PARATHYROID GLAND | M + + + + + + + + + + + + + + + + + + + + + + | 43 | PITUITARY GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 44 | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ADENOMA | | 2| ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | EPIDIDYMIS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PREPUTIAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | PROSTATE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| SEMINAL VESICLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | TESTES | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA | | 1| LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA,LUMBAR | | 1| HISTIOCYTIC SARCOMA,RENAL | | 1| LYMPHOMA MALIGNANT,RENAL | X | 1| LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X | 2| LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | X X | 2| SPLEEN | + + + + + + + + + + + + + + + + + + M + + + + | 46 | HEMANGIOSARCOMA | | 1| LYMPHOMA MALIGNANT | X X | 4| THYMUS | + + + + + + + + + + + M + M M + + M + M + + + | 36 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 140 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:46.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 3| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| S M| | 5| 5| 5| 5| 7| 7| 7| 7| 2| 2| 2| 2| 4| 5| 5| 5| 1| 1| 1| 1| 1| 1| 1| U O| CONTRL MS-2YR 27 27 | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M M M M M M M M + M M M M M M M M M M M M | 3 | SKIN | + + + + + + + + + + + + + + + + + + + + + + + | 47 | FIBROSARCOMA | X | 1| HEMANGIOSARCOMA | X | 1| LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + | 47 | BRAIN,CEREBELLUM | + + M + + + + + + + + + + + + + + + + + + + + | 46 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + | 47 | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + | 47 | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + M + + + + + + + + + | 45 | LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR ADENOMA | X | 4| ALVEOLAR/BRONCHIOLAR CARCINOMA | X | 4| HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X X | 3| HISTIOCYTIC SARCOMA | | 1| NOSE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 141 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:46.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 3| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| S M| | 5| 5| 5| 5| 7| 7| 7| 7| 2| 2| 2| 2| 4| 5| 5| 5| 1| 1| 1| 1| 1| 1| 1| U O| CONTRL MS-2YR 27 27 | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ADENOMA | X X X | 4| LACRIMAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ZYMBAL'S GLAND | + + + + + + + + + + + + + + + + M + + + + + + | 44 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | | 1| URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 142 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:48.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 2| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| | 5| 8| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 2| 4| 4| 4| | 2| 6| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 3| 3| 3| 8| 8| 2| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| S M| | 3| 6| 7| 8| 3| 3| 3| 3| 6| 6| 6| 6| 9| 9| 9| 9| 2| 3| 3| 4| 6| 3| 4| 4| 4| U O| 10MG MS-2YR 28 28 | 7| 7| 5| 0| 6| 7| 8| 9| 6| 7| 8| 9| 5| 6| 7| 8| 3| 8| 9| 0| 5| 0| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + | | GALLBLADDER | A + + + + + | | INTESTINE LARGE | + A A + + + | | INTESTINE LARGE,CECUM | + A A + + + | | INTESTINE LARGE,COLON | + A A + + + | | INTESTINE LARGE,RECTUM | + A A + + + | | INTESTINE SMALL | + A A + + + | | INTESTINE SMALL,DUODENUM | + A A + + + | | INTESTINE SMALL,ILEUM | + A A + + + | | INTESTINE SMALL,JEJUNUM | + A A + + + | | ADENOCARCINOMA | | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | CHOLANGIOCARCINOMA | X | | HEMANGIOSARCOMA | X | | HEPATOCELLULAR ADENOMA | X X X | | HEPATOCELLULAR ADENOMA,MULTIPLE | | | HEPATOCELLULAR CARCINOMA | X X X X X X | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | X | | PANCREAS | + + M + + + | | SALIVARY GLANDS | + + + + + + | | LYMPHOMA MALIGNANT | | | STOMACH | + + A + + + | | STOMACH,FORESTOMACH | + + A + + + | | STOMACH,GLANDULAR | + + A + + + | | TONGUE | + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + | | BLOOD VESSEL,AORTA | + + + + + + | | HEART | + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | M + + + + + | | ADRENAL GLAND,CORTEX | M + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 143 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:49.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 2| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| | 5| 8| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 2| 4| 4| 4| | 2| 6| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 3| 3| 3| 8| 8| 2| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| S M| | 3| 6| 7| 8| 3| 3| 3| 3| 6| 6| 6| 6| 9| 9| 9| 9| 2| 3| 3| 4| 6| 3| 4| 4| 4| U O| 10MG MS-2YR 28 28 | 7| 7| 5| 0| 6| 7| 8| 9| 6| 7| 8| 9| 5| 6| 7| 8| 3| 8| 9| 0| 5| 0| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM LYMPHOMA MALIGNANT | | | ADRENAL GLAND,MEDULLA | M + + + + + | | ISLETS, PANCREATIC | + + M + + + | | PARATHYROID GLAND | + + M + + + | | PITUITARY GLAND | M + M + + + | | THYROID GLAND | + + A + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + + + + | | EPIDIDYMIS | + + + M + + | | PENIS | + | | PREPUTIAL GLAND | + + + M + + + + + | | PROSTATE | + + + M + + | | LYMPHOMA MALIGNANT | | | SEMINAL VESICLE | + + + + + + | | TESTES | + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + | | LYMPHOMA MALIGNANT | | | LYMPH NODE | + + + + + + + + + | | HISTIOCYTIC SARCOMA,RENAL | | | LYMPHOMA MALIGNANT | X | | LYMPH NODE,MANDIBULAR | + + + + + + | | LYMPHOMA MALIGNANT | | | LYMPH NODE,MESENTERIC | A M A + + + + + | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | | | SPLEEN | + + M + + + + + | | HEMANGIOSARCOMA | X | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | X | | THYMUS | M + + M + + | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 144 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:49.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 2| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| | 5| 8| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 2| 4| 4| 4| | 2| 6| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 3| 3| 3| 8| 8| 2| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| S M| | 3| 6| 7| 8| 3| 3| 3| 3| 6| 6| 6| 6| 9| 9| 9| 9| 2| 3| 3| 4| 6| 3| 4| 4| 4| U O| 10MG MS-2YR 28 28 | 7| 7| 5| 0| 6| 7| 8| 9| 6| 7| 8| 9| 5| 6| 7| 8| 3| 8| 9| 0| 5| 0| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M M M M | | SKIN | + + + + + + | | HEMANGIOMA | | | PAPILLOMA | | | SCHWANNOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + | | BONE,FEMUR | + + + + + + | | BONE,STERNUM | + + + + + + | | SKELETAL MUSCLE | + + + + + + + | | LYMPHOMA MALIGNANT | | | SCHWANNOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + | | BRAIN,CEREBELLUM | + + + + + + | | BRAIN,CEREBRUM | + + + + + + | | LYMPHOMA MALIGNANT | | | PERIPHERAL NERVE | + + + + + + | | SPINAL CORD | + + + + + + | | SPINAL CORD,THORACIC | + + + + + + | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + M + + + | | LUNG | + + + + + + + | | CHOLANGIOCARCINOMA,METASTATIC,LIVER | X | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X X X | | LYMPHOMA MALIGNANT | | | NOSE | + + + + + + | | TRACHEA | + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 145 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:49.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 2| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| | 5| 8| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 2| 4| 4| 4| | 2| 6| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 3| 3| 3| 8| 8| 2| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| S M| | 3| 6| 7| 8| 3| 3| 3| 3| 6| 6| 6| 6| 9| 9| 9| 9| 2| 3| 3| 4| 6| 3| 4| 4| 4| U O| 10MG MS-2YR 28 28 | 7| 7| 5| 0| 6| 7| 8| 9| 6| 7| 8| 9| 5| 6| 7| 8| 3| 8| 9| 0| 5| 0| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | A + + + + + + | | HARDERIAN GLAND | + + + + + + + + | | ADENOMA | X X | | LYMPHOMA MALIGNANT | | | LACRIMAL GLAND | + + + + + + | | LYMPHOMA MALIGNANT | | | ZYMBAL'S GLAND | + + + M M + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + | | LYMPHOMA MALIGNANT | | | URINARY BLADDER | + + + + + + | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 146 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:49.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 3| 3| 3| 3| 0| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| S M| | 6| 7| 7| 7| 8| 1| 1| 1| 4| 4| 4| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| U O| 10MG MS-2YR 28 28 | 9| 0| 1| 2| 8| 3| 4| 5| 3| 4| 5| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + | 7 | GALLBLADDER | + | 6 | INTESTINE LARGE | + | 5 | INTESTINE LARGE,CECUM | + | 5 | INTESTINE LARGE,COLON | + | 5 | INTESTINE LARGE,RECTUM | + | 5 | INTESTINE SMALL | + + | 6 | INTESTINE SMALL,DUODENUM | + | 5 | INTESTINE SMALL,ILEUM | + | 5 | INTESTINE SMALL,JEJUNUM | + + | 6 | ADENOCARCINOMA | X | 1| LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | CHOLANGIOCARCINOMA | | 1| HEMANGIOSARCOMA | | 1| HEPATOCELLULAR ADENOMA | X X X | 6| HEPATOCELLULAR ADENOMA,MULTIPLE | X X | 2| HEPATOCELLULAR CARCINOMA | X X X X | 10| HISTIOCYTIC SARCOMA | X | 1| LYMPHOMA MALIGNANT | X X | 3| PANCREAS | + | 6 | SALIVARY GLANDS | + | 7 | LYMPHOMA MALIGNANT | X | 1| STOMACH | + | 6 | STOMACH,FORESTOMACH | + | 6 | STOMACH,GLANDULAR | + | 6 | TONGUE | + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + | 7 | BLOOD VESSEL,AORTA | + | 7 | HEART | + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + | 6 | ADRENAL GLAND,CORTEX | + | 6 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 147 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:50.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 3| 3| 3| 3| 0| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| S M| | 6| 7| 7| 7| 8| 1| 1| 1| 4| 4| 4| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| U O| 10MG MS-2YR 28 28 | 9| 0| 1| 2| 8| 3| 4| 5| 3| 4| 5| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM LYMPHOMA MALIGNANT | X | 1| ADRENAL GLAND,MEDULLA | + | 6 | ISLETS, PANCREATIC | + | 6 | PARATHYROID GLAND | + | 6 | PITUITARY GLAND | + | 5 | THYROID GLAND | + | 6 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + | 7 | EPIDIDYMIS | + | 6 | PENIS | | 1 | PREPUTIAL GLAND | + + | 10 | PROSTATE | + | 6 | LYMPHOMA MALIGNANT | X | 1| SEMINAL VESICLE | + + | 8 | TESTES | + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + | 7 | LYMPHOMA MALIGNANT | X | 1| LYMPH NODE | + + | 11 | HISTIOCYTIC SARCOMA,RENAL | X | 1| LYMPHOMA MALIGNANT | | 1| LYMPH NODE,MANDIBULAR | + | 7 | LYMPHOMA MALIGNANT | X | 1| LYMPH NODE,MESENTERIC | + + | 7 | HISTIOCYTIC SARCOMA | X | 1| LYMPHOMA MALIGNANT | X | 1| SPLEEN | + + + + | 11 | HEMANGIOSARCOMA | | 1| HISTIOCYTIC SARCOMA | X | 1| LYMPHOMA MALIGNANT | X X | 3| THYMUS | + | 5 | LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 148 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:50.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 3| 3| 3| 3| 0| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| S M| | 6| 7| 7| 7| 8| 1| 1| 1| 4| 4| 4| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| U O| 10MG MS-2YR 28 28 | 9| 0| 1| 2| 8| 3| 4| 5| 3| 4| 5| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | M | 0 | SKIN | + + + | 9 | HEMANGIOMA | X | 1| PAPILLOMA | X | 1| SCHWANNOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + | 7 | BONE,FEMUR | + | 7 | BONE,STERNUM | + | 7 | SKELETAL MUSCLE | + | 8 | LYMPHOMA MALIGNANT | X | 1| SCHWANNOMA MALIGNANT | | 2| ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + | 7 | BRAIN,CEREBELLUM | + | 7 | BRAIN,CEREBRUM | + | 7 | LYMPHOMA MALIGNANT | X | 1| PERIPHERAL NERVE | + | 7 | SPINAL CORD | + | 7 | SPINAL CORD,THORACIC | + | 7 | LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + | 6 | LUNG | + | 8 | CHOLANGIOCARCINOMA,METASTATIC,LIVER | | 1| HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | | 3| LYMPHOMA MALIGNANT | X | 1| NOSE | + | 7 | TRACHEA | + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 149 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:50.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 3| 3| 3| 3| 0| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| S M| | 6| 7| 7| 7| 8| 1| 1| 1| 4| 4| 4| 9| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| U O| 10MG MS-2YR 28 28 | 9| 0| 1| 2| 8| 3| 4| 5| 3| 4| 5| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | + | 7 | HARDERIAN GLAND | + + | 10 | ADENOMA | X | 3| LYMPHOMA MALIGNANT | X | 1| LACRIMAL GLAND | + | 7 | LYMPHOMA MALIGNANT | X | 1| ZYMBAL'S GLAND | M | 4 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + | 8 | LYMPHOMA MALIGNANT | X | 1| URINARY BLADDER | + | 7 | LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 150 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:51.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 1| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 7| 0| 2| 2| 2| 2| 5| 5| 5| 5| 8| 8| 8| 8| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 5| U O| 25MG MS-2YR 29 29 | 9| 7| 4| 5| 6| 7| 4| 5| 6| 7| 4| 5| 6| 7| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + | | GALLBLADDER | + M | | INTESTINE LARGE | + A | | INTESTINE LARGE,CECUM | + A | | INTESTINE LARGE,COLON | + A | | INTESTINE LARGE,RECTUM | + A | | INTESTINE SMALL | A A | | INTESTINE SMALL,DUODENUM | A A | | LYMPHOMA MALIGNANT | | | INTESTINE SMALL,ILEUM | A A | | INTESTINE SMALL,JEJUNUM | A A | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | HEPATOCELLULAR ADENOMA | X X X X X | | HEPATOCELLULAR CARCINOMA | X | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X | | PANCREAS | + + | | SALIVARY GLANDS | + + | | HISTIOCYTIC SARCOMA | | | STOMACH | + A | | STOMACH,FORESTOMACH | + A | | STOMACH,GLANDULAR | + A | | TONGUE | + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + | | BLOOD VESSEL,AORTA | + + | | HEART | + + | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + | | ADRENAL GLAND,CORTEX | + + | | ADRENAL GLAND,MEDULLA | + + | | ISLETS, PANCREATIC | + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 151 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:51.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 1| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 7| 0| 2| 2| 2| 2| 5| 5| 5| 5| 8| 8| 8| 8| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 5| U O| 25MG MS-2YR 29 29 | 9| 7| 4| 5| 6| 7| 4| 5| 6| 7| 4| 5| 6| 7| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADENOMA | | | PARATHYROID GLAND | + + | | PITUITARY GLAND | + A | | THYROID GLAND | + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + A | | EPIDIDYMIS | + + | | PREPUTIAL GLAND | + M + + | | PROSTATE | + + | | SEMINAL VESICLE | + A | | TESTES | + + | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + | | LYMPH NODE | + + + + | | LYMPH NODE,MANDIBULAR | + + | | LYMPH NODE,MESENTERIC | + + + + | | HISTIOCYTIC SARCOMA | X | | SPLEEN | + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X | | THYMUS | + M | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M | | SKIN | + + + | | FIBROSARCOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + | | BONE,FEMUR | + + | | BONE,STERNUM | + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 152 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:51.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 1| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 3| 3| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 7| 0| 2| 2| 2| 2| 5| 5| 5| 5| 8| 8| 8| 8| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 5| U O| 25MG MS-2YR 29 29 | 9| 7| 4| 5| 6| 7| 4| 5| 6| 7| 4| 5| 6| 7| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | MUSCULOSKELETAL SYSTEM SKELETAL MUSCLE | + + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + | | BRAIN,CEREBELLUM | + + | | BRAIN,CEREBRUM | + + | | PERIPHERAL NERVE | + + | | SPINAL CORD | + + | | SPINAL CORD,THORACIC | + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + M | | LUNG | + + | | ALVEOLAR/BRONCHIOLAR CARCINOMA | | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X | | HISTIOCYTIC SARCOMA | X | | NOSE | + + | | TRACHEA | + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + | | HARDERIAN GLAND | + + | | ADENOMA | | | LACRIMAL GLAND | + A | | ZYMBAL'S GLAND | + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + | | URINARY BLADDER | + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 153 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:51.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 3| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| S M| | 5| 5| 5| 8| 8| 8| 8| 2| 2| 2| 2| 5| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| 2| U O| 25MG MS-2YR 29 29 | 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | | 2 | GALLBLADDER | | 1 | INTESTINE LARGE | | 1 | INTESTINE LARGE,CECUM | | 1 | INTESTINE LARGE,COLON | | 1 | INTESTINE LARGE,RECTUM | | 1 | INTESTINE SMALL | + | 1 | INTESTINE SMALL,DUODENUM | + | 1 | LYMPHOMA MALIGNANT | X | 1| INTESTINE SMALL,ILEUM | | 0 | INTESTINE SMALL,JEJUNUM | | 0 | LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA | X | 2| HEPATOCELLULAR ADENOMA | X X X X X X X | 12| HEPATOCELLULAR CARCINOMA | X X X X X | 6| HISTIOCYTIC SARCOMA | X | 2| LYMPHOMA MALIGNANT | | 1| PANCREAS | | 2 | SALIVARY GLANDS | + | 3 | HISTIOCYTIC SARCOMA | X | 1| STOMACH | | 1 | STOMACH,FORESTOMACH | | 1 | STOMACH,GLANDULAR | | 1 | TONGUE | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | | 2 | BLOOD VESSEL,AORTA | | 2 | HEART | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | | 2 | ADRENAL GLAND,CORTEX | | 2 | ADRENAL GLAND,MEDULLA | | 2 | ISLETS, PANCREATIC | + | 3 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 154 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:52.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 3| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| S M| | 5| 5| 5| 8| 8| 8| 8| 2| 2| 2| 2| 5| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| 2| U O| 25MG MS-2YR 29 29 | 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADENOMA | X | 1| PARATHYROID GLAND | | 2 | PITUITARY GLAND | | 1 | THYROID GLAND | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | | 1 | EPIDIDYMIS | | 2 | PREPUTIAL GLAND | + + + | 6 | PROSTATE | | 2 | SEMINAL VESICLE | | 1 | TESTES | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | | 2 | LYMPH NODE | | 4 | LYMPH NODE,MANDIBULAR | | 2 | LYMPH NODE,MESENTERIC | | 4 | HISTIOCYTIC SARCOMA | | 1| SPLEEN | | 4 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | | 1| THYMUS | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | | 0 | SKIN | | 3 | FIBROSARCOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | | 2 | BONE,FEMUR | | 2 | BONE,STERNUM | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 155 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:22:52.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 3| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 6| S M| | 5| 5| 5| 8| 8| 8| 8| 2| 2| 2| 2| 5| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2| 2| U O| 25MG MS-2YR 29 29 | 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 3| 4| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | MUSCULOSKELETAL SYSTEM SKELETAL MUSCLE | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | | 2 | BRAIN,CEREBELLUM | | 2 | BRAIN,CEREBRUM | | 2 | PERIPHERAL NERVE | | 2 | SPINAL CORD | | 2 | SPINAL CORD,THORACIC | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | | 1 | LUNG | + + | 4 | ALVEOLAR/BRONCHIOLAR CARCINOMA | X X | 2| HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | | 1| HISTIOCYTIC SARCOMA | | 1| NOSE | | 2 | TRACHEA | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | | 2 | HARDERIAN GLAND | + + | 4 | ADENOMA | X X | 2| LACRIMAL GLAND | | 1 | ZYMBAL'S GLAND | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | | 2 | URINARY BLADDER | | 2 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 156 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:00.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| | 0| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 9| | 9| 1| 5| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 1| 8| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| S M| | 0| 0| 1| 3| 3| 3| 3| 6| 6| 6| 6| 9| 9| 9| 2| 2| 3| 3| 3| 3| 6| 6| 9| 1| 2| U O| 50MG MS-2YR 30 30 | 4| 6| 1| 2| 3| 4| 5| 2| 3| 4| 5| 2| 3| 4| 1| 2| 4| 5| 6| 7| 1| 2| 2| 1| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | M + + + + + + + + + + + + + + + + + + + + + + + + | | GALLBLADDER | M + + + + + + + + + + + + + + M + + + + + + + + M | | INTESTINE LARGE | A + + + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE LARGE,CECUM | A + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | INTESTINE LARGE,COLON | A + + + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE LARGE,RECTUM | A + + + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE SMALL | A + + + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE SMALL,DUODENUM | A + + + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE SMALL,ILEUM | A + A + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE SMALL,JEJUNUM | A + A + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA | X X X X X | | HEPATOCELLULAR ADENOMA,MULTIPLE | X X X | | HEPATOCELLULAR CARCINOMA | X X X X X X X | | HEPATOCELLULAR CARCINOMA,MULTIPLE | X | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X | | PANCREAS | A + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | STOMACH | A + + + + + + + + + + + + + + + + + + + + + + + + | | STOMACH,FORESTOMACH | A + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | STOMACH,GLANDULAR | A + + + + + + + + + + + + + + + + + + + + + + + + | | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | A + + + + + + + + + + + + + + + + + + + + + + + + | | BLOOD VESSEL,AORTA | A + + + + + + + + + + + + + + + + + + + + + + + + | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 157 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:00.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| | 0| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 9| | 9| 1| 5| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 1| 8| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| S M| | 0| 0| 1| 3| 3| 3| 3| 6| 6| 6| 6| 9| 9| 9| 2| 2| 3| 3| 3| 3| 6| 6| 9| 1| 2| U O| 50MG MS-2YR 30 30 | 4| 6| 1| 2| 3| 4| 5| 2| 3| 4| 5| 2| 3| 4| 1| 2| 4| 5| 6| 7| 1| 2| 2| 1| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | A + + + + + + + + + + + + + + + + + + + + + + + + | | CARCINOMA,METASTATIC,LUNG | X | | ADRENAL GLAND,CORTEX | A + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | | | LYMPHOMA MALIGNANT | X | | ADRENAL GLAND,MEDULLA | A + + + + + + + + + + + + + + + + + + + + + + + + | | ISLETS, PANCREATIC | A + + + + + + + + + + + + + + + + + + + + + + + + | | PARATHYROID GLAND | M + + + + + + + + + + + + + + + + + + + + + + + + | | PITUITARY GLAND | M M + + + + + M + + + + + + + + M + + + + + M M M | | THYROID GLAND | M + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENERAL BODY SYSTEM TISSUE NOS | + | | LYMPHOMA MALIGNANT,THORACIC | X | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + + + + + + + + + + + + + + + + + + + + + + M | | LYMPHOMA MALIGNANT | X | | EPIDIDYMIS | + + + + + + + + + + + + + + + + + + + + + + + + + | | PREPUTIAL GLAND | + + + + + + + + + + + + M + + + + + + + + + + + + | | PROSTATE | M + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | SEMINAL VESICLE | + + + + + + + + + + + + + + + + + + + + + + + + M | | LYMPHOMA MALIGNANT | X | | TESTES | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPH NODE | A + + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA,METASTATIC,SKELETAL MUSCLE,AX| | | ILLARY | | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 158 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:00.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| | 0| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 9| | 9| 1| 5| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 1| 8| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| S M| | 0| 0| 1| 3| 3| 3| 3| 6| 6| 6| 6| 9| 9| 9| 2| 2| 3| 3| 3| 3| 6| 6| 9| 1| 2| U O| 50MG MS-2YR 30 30 | 4| 6| 1| 2| 3| 4| 5| 2| 3| 4| 5| 2| 3| 4| 1| 2| 4| 5| 6| 7| 1| 2| 2| 1| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | FIBROSARCOMA,METASTATIC,SKELETAL MUSCLE,TH| | | ORACIC | | | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT,RENAL | X | | LYMPH NODE,MANDIBULAR | A + + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA,METASTATIC,SKELETAL MUSCLE | | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | X | | LYMPH NODE,MESENTERIC | A + + + + + + + + + + + + + + + + + + + + + + M + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X | | SPLEEN | A + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X X | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X | | THYMUS | M M + + + + + + + + + M + + M + + + + + + + + M M | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M + M M M M M + M M M M M M M M M M M M M M M M M | | HISTIOCYTIC SARCOMA | | | SKIN | + + + + + + + M + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | SARCOMA | | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | FIBROSARCOMA,BACK | | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 159 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:00.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| | 0| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 9| | 9| 1| 5| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 1| 8| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| S M| | 0| 0| 1| 3| 3| 3| 3| 6| 6| 6| 6| 9| 9| 9| 2| 2| 3| 3| 3| 3| 6| 6| 9| 1| 2| U O| 50MG MS-2YR 30 30 | 4| 6| 1| 2| 3| 4| 5| 2| 3| 4| 5| 2| 3| 4| 1| 2| 4| 5| 6| 7| 1| 2| 2| 1| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + M + + + + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + M + + + + + + + + + + + + + + + + + + + + + + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X | | ALVEOLAR/BRONCHIOLAR CARCINOMA | X | | ALVEOLAR/BRONCHIOLAR CARCINOMA,MULTIPLE | X | | FIBROSARCOMA,METASTATIC,SKELETAL MUSCLE | | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TRACHEA | M + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | LACRIMAL GLAND | A + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ZYMBAL'S GLAND | + + + + + M + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | A + + + + + + + + + + + + + + + + + + + + + + + + | | CARCINOMA,METASTATIC,LUNG | X | | LYMPHOMA MALIGNANT | X X | | URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 160 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:00.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| | 0| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2| 7| 9| | 9| 1| 5| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 3| 1| 8| 6| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| S M| | 0| 0| 1| 3| 3| 3| 3| 6| 6| 6| 6| 9| 9| 9| 2| 2| 3| 3| 3| 3| 6| 6| 9| 1| 2| U O| 50MG MS-2YR 30 30 | 4| 6| 1| 2| 3| 4| 5| 2| 3| 4| 5| 2| 3| 4| 1| 2| 4| 5| 6| 7| 1| 2| 2| 1| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 161 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:07.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 0| 1| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| S M| | 2| 2| 4| 4| 5| 7| 7| 7| 1| 1| 1| 1| 4| 4| 4| 0| 0| 0| 1| 1| 1| 2| 2| U O| 50MG MS-2YR 30 30 | 5| 8| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 7| 8| 9| 0| 1| 2| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + | 47 | GALLBLADDER | + + + + + M + + + + + + + + + + + M + + + + + | 43 | INTESTINE LARGE | + A + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE LARGE,CECUM | + A + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 2| INTESTINE LARGE,COLON | + A + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE LARGE,RECTUM | + M + + + + + + + + + + + + + + + M + + + + + | 45 | INTESTINE SMALL | + + + + + + + + + + + + + + + + + + + + + + + | 47 | INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + + + + + + + + + + + | 47 | INTESTINE SMALL,ILEUM | + A + + + + + + + + + + + + + + + + + + + + + | 45 | INTESTINE SMALL,JEJUNUM | + A + + + + + + + + + + + + + + + + + + + + + | 45 | LYMPHOMA MALIGNANT | | 1| LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA | X X X | 8| HEPATOCELLULAR ADENOMA,MULTIPLE | | 3| HEPATOCELLULAR CARCINOMA | X X X X | 11| HEPATOCELLULAR CARCINOMA,MULTIPLE | | 1| HISTIOCYTIC SARCOMA | X | 2| LYMPHOMA MALIGNANT | | 2| PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | | 1| SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 1| STOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 47 | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | | 1| STOMACH,GLANDULAR | + + + + + + + + + + + + + + + + + + + + + + + | 47 | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | M + + + + + + + + + + + + + + + + + + + + + + | 46 | BLOOD VESSEL,AORTA | M + + + + + + + + + + + + + + + + + + + + + + | 46 | HEART | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 162 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:07.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 0| 1| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| S M| | 2| 2| 4| 4| 5| 7| 7| 7| 1| 1| 1| 1| 4| 4| 4| 0| 0| 0| 1| 1| 1| 2| 2| U O| 50MG MS-2YR 30 30 | 5| 8| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 7| 8| 9| 0| 1| 2| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | CARCINOMA,METASTATIC,LUNG | | 1| ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ADENOMA | X | 1| LYMPHOMA MALIGNANT | | 1| ADRENAL GLAND,MEDULLA | + + + + + + + + M + + + + + + + + + + + + + + | 46 | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + | 47 | PARATHYROID GLAND | + + + + + + + + + + + + + + + + + M + + + + + | 46 | PITUITARY GLAND | M M + + + + + + + + + + + M + + + M + + + M + | 36 | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ GENERAL BODY SYSTEM TISSUE NOS | M | 1 | LYMPHOMA MALIGNANT,THORACIC | | 1| ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + M + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| EPIDIDYMIS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PREPUTIAL GLAND | + M + + + + + + + + + + + + + + + + + + + + + | 46 | PROSTATE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | | 1| SEMINAL VESICLE | + M + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| TESTES | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | | 1| LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | FIBROSARCOMA,METASTATIC,SKELETAL MUSCLE,AX| X | 1| ILLARY | | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 163 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:07.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 0| 1| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| S M| | 2| 2| 4| 4| 5| 7| 7| 7| 1| 1| 1| 1| 4| 4| 4| 0| 0| 0| 1| 1| 1| 2| 2| U O| 50MG MS-2YR 30 30 | 5| 8| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 7| 8| 9| 0| 1| 2| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | FIBROSARCOMA,METASTATIC,SKELETAL MUSCLE,TH| X | 1| ORACIC | | | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT,RENAL | | 1| LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + M | 46 | FIBROSARCOMA,METASTATIC,SKELETAL MUSCLE | X | 1| HISTIOCYTIC SARCOMA | X | 1| LYMPHOMA MALIGNANT | | 1| LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + | 46 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | | 2| SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HEMANGIOSARCOMA | | 2| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | | 2| THYMUS | M M + + M M + + + + + M + + + + + M + M + + + | 35 | LYMPHOMA MALIGNANT | | 2| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M M M + M M M M M M M M M M M M M + M M M | 4 | HISTIOCYTIC SARCOMA | X | 1| SKIN | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | | 1| SARCOMA | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | FIBROSARCOMA,BACK | X | 1| LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 164 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:07.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 0| 1| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| S M| | 2| 2| 4| 4| 5| 7| 7| 7| 1| 1| 1| 1| 4| 4| 4| 0| 0| 0| 1| 1| 1| 2| 2| U O| 50MG MS-2YR 30 30 | 5| 8| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 7| 8| 9| 0| 1| 2| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + M | 46 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SPINAL CORD,THORACIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | M + + + + + + + + + + + + + + + + + + + + M + | 45 | LUNG | + + + + + M + + + + + + + + + + + + + + + + + | 47 | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X X | 7| ALVEOLAR/BRONCHIOLAR CARCINOMA | X X | 3| ALVEOLAR/BRONCHIOLAR CARCINOMA,MULTIPLE | | 1| FIBROSARCOMA,METASTATIC,SKELETAL MUSCLE | X | 1| HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X X | 2| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | | 1| NOSE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 1| HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LACRIMAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | | 1| ZYMBAL'S GLAND | + + + + + + + + + + + + + + + + + M + + + + M | 45 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + | 47 | CARCINOMA,METASTATIC,LUNG | | 1| LYMPHOMA MALIGNANT | | 2| URINARY BLADDER | + + + + + + + + + + + + + + + + + + + M + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 165 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:08.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 0| 1| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 7| 7| S M| | 2| 2| 4| 4| 5| 7| 7| 7| 1| 1| 1| 1| 4| 4| 4| 0| 0| 0| 1| 1| 1| 2| 2| U O| 50MG MS-2YR 30 30 | 5| 8| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 7| 8| 9| 0| 1| 2| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 166 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:09.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 1| 1| 1| 1| 1| 1| 1| 1| | 1| 1| 1| 1| 1| 1| 1| 1| | 9| 9| 9| 9| 9| 9| 9| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 0| 0| 0| 0| 0| 0| 1| 1| U O| 100MG F120 DAYS 36 | 4| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + | 8 | GALLBLADDER | + + + + + + + + | 8 | INTESTINE LARGE | + + + + + + + + | 8 | INTESTINE LARGE,CECUM | + + + + + + + + | 8 | INTESTINE LARGE,COLON | + + + + + + + + | 8 | INTESTINE LARGE,RECTUM | + + + + + + + + | 8 | INTESTINE SMALL | + + + + + + + + | 8 | INTESTINE SMALL,DUODENUM | + + + + + M + + | 7 | INTESTINE SMALL,ILEUM | + + + + + + + + | 8 | INTESTINE SMALL,JEJUNUM | + + + + + + + + | 8 | LIVER | + + + + + + + + | 8 | PANCREAS | + + + + + + + + | 8 | SALIVARY GLANDS | + + + + + + + + | 8 | STOMACH | + + + + + + + + | 8 | STOMACH,FORESTOMACH | + + + + + + + + | 8 | STOMACH,GLANDULAR | + + + + + + + + | 8 | TONGUE | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + M M + + | 6 | BLOOD VESSEL,AORTA | + + + + M M + + | 6 | HEART | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + | 8 | ADRENAL GLAND,CORTEX | + + + + + + + + | 8 | ADRENAL GLAND,MEDULLA | + + + + + + + + | 8 | ISLETS, PANCREATIC | + + + + + + + + | 8 | PARATHYROID GLAND | + + + + + + + M | 7 | PITUITARY GLAND | + + + + + M + + | 7 | THYROID GLAND | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 167 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:09.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 1| 1| 1| 1| 1| 1| 1| 1| | 1| 1| 1| 1| 1| 1| 1| 1| | 9| 9| 9| 9| 9| 9| 9| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 0| 0| 0| 0| 0| 0| 1| 1| U O| 100MG F120 DAYS 36 | 4| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | GENITAL SYSTEM CLITORAL GLAND | + + + M + + M M | 5 | OVARY | + + + + + + + + | 8 | UTERUS | + + + + + + + + | 8 | VAGINA | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + | 8 | LYMPH NODE | + + + + + + + + | 8 | LYMPH NODE,MANDIBULAR | + + + + + + + + | 8 | LYMPH NODE,MESENTERIC | + + + + + + + + | 8 | SPLEEN | + + + + + + + + | 8 | THYMUS | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + | 8 | SKIN | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + | 8 | BONE,FEMUR | + + + + + + + + | 8 | BONE,STERNUM | + + + + + + + + | 8 | SKELETAL MUSCLE | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + | 8 | BRAIN,CEREBELLUM | + + + + + + + + | 8 | BRAIN,CEREBRUM | + + + + + + + + | 8 | PERIPHERAL NERVE | + + + + + + + + | 8 | SPINAL CORD | + + + + + + + + | 8 | SPINAL CORD,THORACIC | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 168 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:09.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 1| 1| 1| 1| 1| 1| 1| 1| | 1| 1| 1| 1| 1| 1| 1| 1| | 9| 9| 9| 9| 9| 9| 9| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 0| 0| 0| 0| 0| 0| 1| 1| U O| 100MG F120 DAYS 36 | 4| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM LARYNX | + + + + M M + + | 6 | LUNG | + + + + + + + + | 8 | NOSE | + + + + + + + + | 8 | TRACHEA | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + | 8 | HARDERIAN GLAND | + + + + + + + + | 8 | LACRIMAL GLAND | + + + + + + + + | 8 | ZYMBAL'S GLAND | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + | 8 | URINARY BLADDER | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 169 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:11.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 2| 2| 2| 2| 2| 2| 2| 2| | 1| 1| 1| 1| 1| 1| 1| 1| | 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 2| 3| 3| 3| 3| 3| 3| 3| U O| 100MG F210 DAYS 37 | 9| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + | 8 | GALLBLADDER | + + + + + + + + | 8 | INTESTINE LARGE | + + + + + + + + | 8 | INTESTINE LARGE,CECUM | + + + + + + + + | 8 | INTESTINE LARGE,COLON | + + + + + + + + | 8 | INTESTINE LARGE,RECTUM | + + + + + + + + | 8 | INTESTINE SMALL | + + + + + + + + | 8 | INTESTINE SMALL,DUODENUM | + M + + + + + + | 7 | INTESTINE SMALL,ILEUM | + + + + + + + + | 8 | INTESTINE SMALL,JEJUNUM | + + + + + + + + | 8 | LIVER | + + + + + + + + | 8 | PANCREAS | + + + + + + + + | 8 | SALIVARY GLANDS | + + + + + + + + | 8 | STOMACH | + + + + + + + + | 8 | STOMACH,FORESTOMACH | + + + + + + + + | 8 | STOMACH,GLANDULAR | + + + + + + + + | 8 | TONGUE | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + M + + + + | 7 | BLOOD VESSEL,AORTA | + + + M + + + + | 7 | HEART | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + | 8 | ADRENAL GLAND,CORTEX | + + + + + + + + | 8 | ADRENAL GLAND,MEDULLA | + M + + + + + + | 7 | ISLETS, PANCREATIC | + + + + + + + + | 8 | PARATHYROID GLAND | + M + M + + + + | 6 | PITUITARY GLAND | + M + M + M M M | 3 | THYROID GLAND | M M + + + + + + | 6 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 170 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:11.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 2| 2| 2| 2| 2| 2| 2| 2| | 1| 1| 1| 1| 1| 1| 1| 1| | 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 2| 3| 3| 3| 3| 3| 3| 3| U O| 100MG F210 DAYS 37 | 9| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | GENITAL SYSTEM CLITORAL GLAND | M M + + M M + + | 4 | OVARY | + + + + + + + + | 8 | UTERUS | + + + + + + + + | 8 | VAGINA | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + | 8 | LYMPH NODE | + + + + + + + + | 8 | LYMPH NODE,MANDIBULAR | + + + + + + + + | 8 | LYMPH NODE,MESENTERIC | + + + + + + + + | 8 | SPLEEN | + + + + + + + + | 8 | THYMUS | M + + + + + + + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + M + + + + + | 7 | SKIN | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + | 8 | BONE,FEMUR | + + + + + + + + | 8 | BONE,STERNUM | + + + + + + + + | 8 | SKELETAL MUSCLE | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + | 8 | BRAIN,CEREBELLUM | + + + + + + + + | 8 | BRAIN,CEREBRUM | + + + + + + + + | 8 | PERIPHERAL NERVE | + + + + + + + + | 8 | SPINAL CORD | + + + + + + + + | 8 | SPINAL CORD,THORACIC | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 171 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:11.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 2| 2| 2| 2| 2| 2| 2| 2| | 1| 1| 1| 1| 1| 1| 1| 1| | 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 2| 3| 3| 3| 3| 3| 3| 3| U O| 100MG F210 DAYS 37 | 9| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM LARYNX | + M + + + M + M | 5 | LUNG | + + + + + + + + | 8 | NOSE | + + + + + + + + | 8 | TRACHEA | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + | 8 | HARDERIAN GLAND | + + + + + + + + | 8 | LACRIMAL GLAND | M + + + + + + + | 7 | ZYMBAL'S GLAND | + + M + + + M + | 6 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + | 8 | URINARY BLADDER | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 172 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:13.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 3| 3| 3| 3| 3| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| | 2| 2| 2| 2| 2| 2| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 4| 4| 5| 5| 5| 5| 5| 5| U O| 100MG F392 DAYS 38 | 8| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + | 8 | GALLBLADDER | + + + M M + + + | 6 | INTESTINE LARGE | + + + + + + + + | 8 | INTESTINE LARGE,CECUM | + + + + + + + + | 8 | INTESTINE LARGE,COLON | + + + + + + + + | 8 | INTESTINE LARGE,RECTUM | + M M + + + + + | 6 | INTESTINE SMALL | + + + + + + + + | 8 | INTESTINE SMALL,DUODENUM | + + + M + + + + | 7 | INTESTINE SMALL,ILEUM | + + + + + + + + | 8 | INTESTINE SMALL,JEJUNUM | + + + + + + + + | 8 | LIVER | + + + + + + + + | 8 | PANCREAS | + + + + + + + + | 8 | SALIVARY GLANDS | + + + + + + + + | 8 | STOMACH | + + + + + + + + | 8 | STOMACH,FORESTOMACH | + + + + + + + + | 8 | STOMACH,GLANDULAR | + + + + + + + + | 8 | TONGUE | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | M M + + + + + + | 6 | BLOOD VESSEL,AORTA | M M + + + + + + | 6 | HEART | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + | 8 | ADRENAL GLAND,CORTEX | + + + + + + + + | 8 | ADRENAL GLAND,MEDULLA | + + + + + + + + | 8 | ISLETS, PANCREATIC | + + + + + + + + | 8 | PARATHYROID GLAND | + + M + + + M + | 6 | PITUITARY GLAND | M + + M M + + + | 5 | THYROID GLAND | + + M + + + M + | 6 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 173 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:13.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 3| 3| 3| 3| 3| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| | 2| 2| 2| 2| 2| 2| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 4| 4| 5| 5| 5| 5| 5| 5| U O| 100MG F392 DAYS 38 | 8| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | GENITAL SYSTEM CLITORAL GLAND | + + M M + + + + | 6 | OVARY | + + + + M + + + | 7 | UTERUS | + + + + + + + + | 8 | VAGINA | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + | 8 | LYMPH NODE | + + + + + + + + | 8 | LYMPH NODE,MANDIBULAR | + + + + + + + + | 8 | LYMPH NODE,MESENTERIC | + + + + + + + + | 8 | SPLEEN | + + + + + + + + | 8 | THYMUS | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + + + + + + + | 8 | SKIN | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + | 8 | BONE,FEMUR | + + + + + + + + | 8 | BONE,STERNUM | + + + + + + + + | 8 | SKELETAL MUSCLE | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + | 8 | BRAIN,CEREBELLUM | + + + + + + + + | 8 | BRAIN,CEREBRUM | + + + + + + + + | 8 | PERIPHERAL NERVE | + + + + + + + + | 8 | SPINAL CORD | + + + + + + + + | 8 | SPINAL CORD,THORACIC | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211601 PAGE: 174 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/03/2000 PATHOLOGY REPORT 3 TIME: 15:23:13.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 3| 3| 3| 3| 3| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| | 2| 2| 2| 2| 2| 2| 2| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| S U| FEMALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| S M| | 4| 4| 5| 5| 5| 5| 5| 5| U O| 100MG F392 DAYS 38 | 8| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM LARYNX | + + M + M + M M | 4 | LUNG | + + + + + + + + | 8 | NOSE | + + + + + + + + | 8 | TRACHEA | + M + + + + M + | 6 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + | 8 | HARDERIAN GLAND | + + + + + + + + | 8 | LACRIMAL GLAND | + + + + + + + + | 8 | ZYMBAL'S GLAND | + M M + + + M + | 5 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + | 8 | URINARY BLADDER | + + + + + + + + | 8 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED