NCTR Study 211701 Pathology Tables
NCTR EXP/TEST: 211701 PAGE: 1 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:23:47.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3| S M| | 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 5| 5| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| U O| CONTROL A 2YR 1 1 | 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + + + | | GALLBLADDER | M + + + + + + + + + + + + + + + + + + + + + + + M | | LYMPHOMA MALIGNANT | X X | | INTESTINE LARGE | A M + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE LARGE,CECUM | A M + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE LARGE,COLON | A M + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE LARGE,RECTUM | A M + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE SMALL | A M + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE SMALL,DUODENUM | A M + + + + + + + + + + + + + + + + + + + + + + A | | LYMPHOMA MALIGNANT | X X | | INTESTINE SMALL,ILEUM | A M + + + + + + + + + + + + + + + + + + + + + + A | | LYMPHOMA MALIGNANT | X | | INTESTINE SMALL,JEJUNUM | A M + + + + + + + + + + + + + + + + + + + + + + A | | LYMPHOMA MALIGNANT | X | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA,SINGLE | X X X X X | | HEPATOCELLULAR ADENOMA,TWO | X | | HEPATOCELLULAR CARCINOMA,FOUR | X | | HEPATOCELLULAR CARCINOMA,SINGLE | | | LYMPHOMA MALIGNANT | X X | | PANCREAS | + A + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | STOMACH | + M + + + + + + + + + + + + + + + + + + + + + + A | | STOMACH,FORESTOMACH | + M + + + + + + + + + + + + + + + + + + + + + + A | | STOMACH,GLANDULAR | + M + + + + + + + + + + + + + + + + + + + + + + A | | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 2 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:23:47.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3| S M| | 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 5| 5| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| U O| CONTROL A 2YR 1 1 | 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + M + + + + + + M | | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + M + + + + + + M | | LYMPHOMA MALIGNANT | X | | ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + + + M + + + + + + M | | LYMPHOMA MALIGNANT | X | | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | CARCINOMA | | | PARATHYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | PITUITARY GLAND | + M M + + + + + + + M + + + + + + + + + + + + + + | | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA,FOLLICULAR CELL | | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + A + + + + + + + + + + + + + + + + + + + + + + + | | EPIDIDYMIS | + A + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | PREPUTIAL GLAND | + A + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | PROSTATE | A + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | SEMINAL VESICLE | + A + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | TESTES | + A + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA,INTERSTITIAL CELL | | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA,METASTATIC,SPLEEN | | | LYMPHOMA MALIGNANT | X | | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT,AXILLARY | X | | LYMPHOMA MALIGNANT,LUMBAR | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 3 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:23:47.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3| S M| | 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 5| 5| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| U O| CONTROL A 2YR 1 1 | 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT,RENAL | X | | LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA,METASTATIC,SPLEEN | | | LYMPHOMA MALIGNANT | X X X | | SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | | | LYMPHOMA MALIGNANT | X X X X | | THYMUS | + + + + + + M + + + M + + M M + + + M M + + M M M | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + + M M M M M + + M + M M M M M M M M M M M M M M | | LYMPHOMA MALIGNANT | X | | SKIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | FIBROMA | | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + M + | | LYMPHOMA MALIGNANT | X | | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 4 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:23:47.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3| S M| | 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 5| 5| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6| U O| CONTROL A 2YR 1 1 | 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X X X X | | ALVEOLAR/BRONCHIOLAR ADENOMA,TWO | | | ALVEOLAR/BRONCHIOLAR CARCINOMA | X X | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X | | LYMPHOMA MALIGNANT | X X | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | A + + + + + + + + + + + + + + + + + + + + + + + + | | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | | | LYMPHOMA MALIGNANT | X X | | LACRIMAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ZYMBAL'S GLAND | + M + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | URINARY BLADDER | A + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 5 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:23:55.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| S M| | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| U O| CONTROL A 2YR 1 1 | 0| 1| 9| 1| 2| 3| 4| 5| 6| 7| 8| 5| 8| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + A + + + + + + + + + + + + + + + + + + + + + | 47 | GALLBLADDER | A A M + + + + + + + + + + + + + + + + + + + + | 43 | LYMPHOMA MALIGNANT | | 2| INTESTINE LARGE | A A A + + + + + + + + + A + + + + + + + + + + | 41 | INTESTINE LARGE,CECUM | A A A + + + + + + + + + A + + + + + + + + + + | 41 | INTESTINE LARGE,COLON | A A A + + + + + + + + + A + + + + + + + + + + | 41 | INTESTINE LARGE,RECTUM | A A A + + + + + + + + + A + + + + + + + + + + | 41 | INTESTINE SMALL | A A A + + + + + + + + + + + + + + + + + + + + | 42 | INTESTINE SMALL,DUODENUM | A A A + + + + + + + + + A + + + + + + + + + + | 41 | LYMPHOMA MALIGNANT | | 2| INTESTINE SMALL,ILEUM | A A A + + + + + + + + + + + + + + + + + + + + | 42 | LYMPHOMA MALIGNANT | X | 2| INTESTINE SMALL,JEJUNUM | A A A + + + + + + + + + + + + + + + + + + + + | 42 | LYMPHOMA MALIGNANT | X | 2| LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA,SINGLE | X X X X X | 10| HEPATOCELLULAR ADENOMA,TWO | X | 2| HEPATOCELLULAR CARCINOMA,FOUR | | 1| HEPATOCELLULAR CARCINOMA,SINGLE | X X X | 3| LYMPHOMA MALIGNANT | | 2| PANCREAS | + A + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 1| STOMACH | A A A + + + + + + + + + + + + + + + + + + + + | 43 | STOMACH,FORESTOMACH | A A A + + + + + + + + + + + + + + + + + + + + | 43 | STOMACH,GLANDULAR | A A A + + + + + + + + + + + + + + + + + + + + | 43 | TONGUE | + A + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 1| HEART | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 6 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:23:55.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| S M| | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| U O| CONTROL A 2YR 1 1 | 0| 1| 9| 1| 2| 3| 4| 5| 6| 7| 8| 5| 8| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + A + + + + + + + + + + + + + + + + + + + + + | 45 | ADRENAL GLAND,CORTEX | + A + + + + + + + + + + + + + + + + + + + + + | 45 | LYMPHOMA MALIGNANT | X | 2| ADRENAL GLAND,MEDULLA | + A + + + + + + + + + + + + + + + + + + + + + | 45 | LYMPHOMA MALIGNANT | | 1| ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | CARCINOMA | X | 1| PARATHYROID GLAND | + A + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | | 1| PITUITARY GLAND | + A + + + + + + + + + + M + + + + + M + + + + | 42 | THYROID GLAND | + A + + + + + + + + + + + + + + + + + + + + + | 47 | ADENOMA,FOLLICULAR CELL | X | 1| LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + A + + + + + + + + + + + + + + + + + + + + + | 46 | EPIDIDYMIS | + A + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| PREPUTIAL GLAND | + A + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| PROSTATE | + A + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| SEMINAL VESICLE | + A + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| TESTES | A A + + + + + + + + + + + + + + + + + + + + + | 45 | ADENOMA,INTERSTITIAL CELL | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + A + + + + + + + + + + + + + + + + + + + + + | 47 | HEMANGIOSARCOMA,METASTATIC,SPLEEN | X | 1| LYMPHOMA MALIGNANT | | 1| LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT,AXILLARY | | 1| LYMPHOMA MALIGNANT,LUMBAR | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 7 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:23:55.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| S M| | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| U O| CONTROL A 2YR 1 1 | 0| 1| 9| 1| 2| 3| 4| 5| 6| 7| 8| 5| 8| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM LYMPHOMA MALIGNANT,RENAL | X | 2| LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | | 2| LYMPH NODE,MESENTERIC | + A + + + + + + + + + + + + + + + + + + + + + | 47 | HEMANGIOSARCOMA,METASTATIC,SPLEEN | X | 1| LYMPHOMA MALIGNANT | X | 4| SPLEEN | + A + + + + + + + + + + + + + + + + + + + + + | 47 | HEMANGIOSARCOMA | X | 1| LYMPHOMA MALIGNANT | X | 5| THYMUS | + M M + + + + M + + + + M + + M + M M M M M + | 29 | LYMPHOMA MALIGNANT | | 2| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M M M M M M M M M M M M M M M M M M M M M | 5 | LYMPHOMA MALIGNANT | | 1| SKIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | FIBROMA | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + A + + + + + + + + + + + + + + + + + + + + + | 47 | BONE,FEMUR | + A + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| BONE,STERNUM | + A + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | | 1| SKELETAL MUSCLE | + A + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + A + + + + + + + + + + + + + + + + + + + + + | 47 | BRAIN,CEREBELLUM | + A + + + + + + + + + + + + + + + + + + + + + | 47 | BRAIN,CEREBRUM | + A + + + + + + + + + + + + + + + + + + + + + | 47 | PERIPHERAL NERVE | + A + + + + + + + + + + + + + + + + + + + + + | 47 | SPINAL CORD | + A + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 8 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:23:55.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| S M| | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| U O| CONTROL A 2YR 1 1 | 0| 1| 9| 1| 2| 3| 4| 5| 6| 7| 8| 5| 8| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM LARYNX | + A + + + + + + M + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X X X X | 12| ALVEOLAR/BRONCHIOLAR ADENOMA,TWO | X | 1| ALVEOLAR/BRONCHIOLAR CARCINOMA | | 2| HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | | 1| LYMPHOMA MALIGNANT | | 2| NOSE | + A + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | | 1| TRACHEA | + A + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + A + + + + + + + + + + + + + + + + + + + + + | 46 | HARDERIAN GLAND | + A + + + + + + + + + + + + + + + + + + + + + | 47 | ADENOMA | X X X X X | 5| LYMPHOMA MALIGNANT | | 2| LACRIMAL GLAND | + + + + + + + + + + + + + + + + + + + + + + M | 47 | ZYMBAL'S GLAND | + A + + + + + + + M + + + + + + + + + + + + + | 45 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + A A + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 2| URINARY BLADDER | + A + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 2| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 9 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:23:58.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 3| 5| 7| 3| 2| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 8| 3| 6| 5| 4| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3| S M| | 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 6| 8| 9| 9| 9| 9| 9| 9| 6| U O| 25 MG/KGA 2YR 2 2 | 4| 6| 8| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + | | GALLBLADDER | + + + + + + + | | INTESTINE LARGE | + + A A A A A | | INTESTINE LARGE,CECUM | + + A A A A A | | INTESTINE LARGE,COLON | + + A A A A A | | INTESTINE LARGE,RECTUM | + + A A A A A | | INTESTINE SMALL | + + A A + A + A | | INTESTINE SMALL,DUODENUM | + + A A + A + A | | LYMPHOMA MALIGNANT | X | | INTESTINE SMALL,ILEUM | + + A A A A A | | HISTIOCYTIC SARCOMA | | | INTESTINE SMALL,JEJUNUM | + + A A A A A | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOMA | X | | HEPATOCELLULAR ADENOMA,FOUR | X | | HEPATOCELLULAR ADENOMA,MULTIPLE | X | | HEPATOCELLULAR ADENOMA,SINGLE | X X X X X X X X | | HEPATOCELLULAR ADENOMA,THREE | | | HEPATOCELLULAR ADENOMA,TWO | X X X | | HEPATOCELLULAR CARCINOMA | X | | HEPATOCELLULAR CARCINOMA,SINGLE | X X X X X | | PANCREAS | + + + + + + + | | CARCINOMA,DUCT | X | | HISTIOCYTIC SARCOMA | | | SALIVARY GLANDS | + + A + + + + | | LYMPHOMA MALIGNANT | X | | STOMACH | + + + + + + + | | STOMACH,FORESTOMACH | + + + + + + + | | STOMACH,GLANDULAR | + + + + + + + | | TONGUE | + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + | | CARCINOMA,METASTATIC,PANCREAS | X | | HEART | + + + + + + + | | CARCINOMA,METASTATIC,PANCREAS | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 10 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:23:58.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 3| 5| 7| 3| 2| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 8| 3| 6| 5| 4| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3| S M| | 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 6| 8| 9| 9| 9| 9| 9| 9| 6| U O| 25 MG/KGA 2YR 2 2 | 4| 6| 8| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + | | ADRENAL GLAND,CORTEX | + + + + + + + | | LYMPHOMA MALIGNANT | X | | ADRENAL GLAND,MEDULLA | + + + + + + + | | ISLETS, PANCREATIC | + + + + + + + | | PARATHYROID GLAND | + + M M + M + | | PITUITARY GLAND | M + + + + + + | | THYROID GLAND | + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + + + + + | | LYMPHOMA MALIGNANT | X | | EPIDIDYMIS | + + + + + + + | | LYMPHOMA MALIGNANT | X | | PREPUTIAL GLAND | + + M + + + + | | PROSTATE | + + + + + + + | | LYMPHOMA MALIGNANT | X | | SEMINAL VESICLE | + + + + + + + | | LYMPHOMA MALIGNANT | X | | TESTES | + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + | | LYMPH NODE | + + + + + + + + + + + | | HISTIOCYTIC SARCOMA,BRONCHIAL | | | HISTIOCYTIC SARCOMA,RENAL | | | LYMPHOMA MALIGNANT,LUMBAR | X | | LYMPH NODE,MANDIBULAR | + + A + + + + | | LYMPH NODE,MESENTERIC | + + + + + + + + + + | | CARCINOMA,METASTATIC,PANCREAS | X | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | X X | | SPLEEN | + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 11 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:23:58.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 3| 5| 7| 3| 2| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 8| 3| 6| 5| 4| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3| S M| | 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 6| 8| 9| 9| 9| 9| 9| 9| 6| U O| 25 MG/KGA 2YR 2 2 | 4| 6| 8| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM THYMUS | + M M + + M + M | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M M M M M | | SKIN | + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + | | BONE,FEMUR | + + + + + + + | | BONE,STERNUM | + + + + + + + | | SKELETAL MUSCLE | + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + | | PERIPHERAL NERVE | + + + + + + + | | SPINAL CORD | + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + | | LUNG | + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X | | ALVEOLAR/BRONCHIOLAR ADENOMA,TWO | X | | ALVEOLAR/BRONCHIOLAR CARCINOMA | X X X | | CARCINOMA,METASTATIC,PANCREAS | X | | LYMPHOMA MALIGNANT | X | | NOSE | + + + + + + + | | TRACHEA | + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 12 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:23:58.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 3| 5| 7| 3| 2| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 8| 3| 6| 5| 4| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3| S M| | 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 6| 8| 9| 9| 9| 9| 9| 9| 6| U O| 25 MG/KGA 2YR 2 2 | 4| 6| 8| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | + + + + + + + + | | HARDERIAN GLAND | + + + + + + + + + + + | | ADENOMA | X X X X | | CARCINOMA | X | | LACRIMAL GLAND | + + A + + + + | | LYMPHOMA MALIGNANT | X | | ZYMBAL'S GLAND | + + + + + M + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + | | CARCINOMA,METASTATIC,PANCREAS | X | | URINARY BLADDER | + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 13 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:00.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 8| 2| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 4| 7| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| S M| | 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 9| 5| 5| 6| 9| 9| 9| 9| 9| 9| 9| U O| 25 MG/KGA 2YR 2 2 | 9| 3| 4| 5| 9| 0| 1| 2| 3| 4| 5| 6| 7| 6| 7| 9| 2| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + | 11 | GALLBLADDER | + + + M | 10 | INTESTINE LARGE | + + + A | 5 | INTESTINE LARGE,CECUM | + + + A | 5 | INTESTINE LARGE,COLON | + + + A | 5 | INTESTINE LARGE,RECTUM | + + + A | 5 | INTESTINE SMALL | + + + A | 7 | INTESTINE SMALL,DUODENUM | + + + A | 7 | LYMPHOMA MALIGNANT | | 1| INTESTINE SMALL,ILEUM | + + + A | 5 | HISTIOCYTIC SARCOMA | X | 1| INTESTINE SMALL,JEJUNUM | + + + A | 5 | LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOMA | | 1| HEPATOCELLULAR ADENOMA,FOUR | | 1| HEPATOCELLULAR ADENOMA,MULTIPLE | | 1| HEPATOCELLULAR ADENOMA,SINGLE | X X X | 11| HEPATOCELLULAR ADENOMA,THREE | X | 1| HEPATOCELLULAR ADENOMA,TWO | X X | 5| HEPATOCELLULAR CARCINOMA | | 1| HEPATOCELLULAR CARCINOMA,SINGLE | X X X X | 9| PANCREAS | + + + M | 10 | CARCINOMA,DUCT | | 1| HISTIOCYTIC SARCOMA | X | 1| SALIVARY GLANDS | + + + + | 10 | LYMPHOMA MALIGNANT | | 1| STOMACH | + + + A | 10 | STOMACH,FORESTOMACH | + + + A | 10 | STOMACH,GLANDULAR | + + + A | 10 | TONGUE | + + + A | 10 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + | 11 | CARCINOMA,METASTATIC,PANCREAS | | 1| HEART | + + + + | 11 | CARCINOMA,METASTATIC,PANCREAS | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 14 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:00.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 8| 2| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 4| 7| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| S M| | 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 9| 5| 5| 6| 9| 9| 9| 9| 9| 9| 9| U O| 25 MG/KGA 2YR 2 2 | 9| 3| 4| 5| 9| 0| 1| 2| 3| 4| 5| 6| 7| 6| 7| 9| 2| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + + | 11 | ADRENAL GLAND,CORTEX | + + + + | 11 | LYMPHOMA MALIGNANT | | 1| ADRENAL GLAND,MEDULLA | + + + + | 11 | ISLETS, PANCREATIC | + + + M | 10 | PARATHYROID GLAND | + + M M | 6 | PITUITARY GLAND | + + + + | 10 | THYROID GLAND | + + + + | 11 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + A | 10 | LYMPHOMA MALIGNANT | | 1| EPIDIDYMIS | + + + A | 10 | LYMPHOMA MALIGNANT | | 1| PREPUTIAL GLAND | + + + A + | 10 | PROSTATE | + + + A | 10 | LYMPHOMA MALIGNANT | | 1| SEMINAL VESICLE | + + + A + | 11 | LYMPHOMA MALIGNANT | | 1| TESTES | + + + + | 11 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + A | 10 | LYMPH NODE | + + + + | 15 | HISTIOCYTIC SARCOMA,BRONCHIAL | X | 1| HISTIOCYTIC SARCOMA,RENAL | X | 1| LYMPHOMA MALIGNANT,LUMBAR | | 1| LYMPH NODE,MANDIBULAR | + + + + | 10 | LYMPH NODE,MESENTERIC | + + + A | 13 | CARCINOMA,METASTATIC,PANCREAS | | 1| HISTIOCYTIC SARCOMA | X X | 2| LYMPHOMA MALIGNANT | | 2| SPLEEN | + + + A | 16 | HISTIOCYTIC SARCOMA | X | 1| LYMPHOMA MALIGNANT | | 2| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 15 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:00.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 8| 2| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 4| 7| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| S M| | 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 9| 5| 5| 6| 9| 9| 9| 9| 9| 9| 9| U O| 25 MG/KGA 2YR 2 2 | 9| 3| 4| 5| 9| 0| 1| 2| 3| 4| 5| 6| 7| 6| 7| 9| 2| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM THYMUS | M M + M + | 6 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M M | 0 | SKIN | + + + A | 10 | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + | 11 | BONE,FEMUR | + + + + | 11 | BONE,STERNUM | + + + + | 11 | SKELETAL MUSCLE | + + + A | 10 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + A | 10 | BRAIN,CEREBELLUM | + + + A | 10 | BRAIN,CEREBRUM | + + + A | 10 | PERIPHERAL NERVE | + + + A | 10 | SPINAL CORD | + + + A | 10 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + | 11 | LUNG | + + + + + + + + + + | 20 | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X X | 6| ALVEOLAR/BRONCHIOLAR ADENOMA,TWO | X | 2| ALVEOLAR/BRONCHIOLAR CARCINOMA | X | 4| CARCINOMA,METASTATIC,PANCREAS | | 1| LYMPHOMA MALIGNANT | | 1| NOSE | + + + + | 11 | TRACHEA | + + + A | 10 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 16 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:00.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 8| 2| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 4| 7| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| S M| | 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 9| 5| 5| 6| 9| 9| 9| 9| 9| 9| 9| U O| 25 MG/KGA 2YR 2 2 | 9| 3| 4| 5| 9| 0| 1| 2| 3| 4| 5| 6| 7| 6| 7| 9| 2| 3| 4| 5| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM EYE | + + + A | 11 | HARDERIAN GLAND | + + + A + + | 16 | ADENOMA | X X | 6| CARCINOMA | | 1| LACRIMAL GLAND | + + + + | 10 | LYMPHOMA MALIGNANT | | 1| ZYMBAL'S GLAND | + + + A | 9 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + A | 10 | CARCINOMA,METASTATIC,PANCREAS | | 1| URINARY BLADDER | + + + A | 10 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 17 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:04.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 5| 5| 8| 2| 2| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 2| 2| 1| 8| 9| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| S M| | 0| 6| 6| 7| 7| 7| 8| 9| 0| 0| 0| 0| 0| 0| 5| 6| 9| 9| 9| 9| 0| 0| 0| 0| 6| U O| 50 MG/KGA 2YR 3 3 | 5| 5| 9| 2| 3| 8| 1| 9| 0| 1| 2| 3| 4| 5| 4| 9| 6| 7| 8| 9| 0| 1| 2| 3| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + | | GALLBLADDER | + + + + + + + + | | INTESTINE LARGE | + A A A A A + A | | INTESTINE LARGE,CECUM | + A A A A A + A | | INTESTINE LARGE,COLON | + A A A A A + A | | INTESTINE LARGE,RECTUM | + A A A A A + A | | INTESTINE SMALL | + A A A A A + + A | | INTESTINE SMALL,DUODENUM | + A A A A A + A | | INTESTINE SMALL,ILEUM | + A A A A A + + A | | LYMPHOMA MALIGNANT | X | | INTESTINE SMALL,JEJUNUM | + A A A A A + A | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | CARCINOMA,BILE DUCT | X | | HEPATOCELLULAR ADENOMA,MULTIPLE | X | | HEPATOCELLULAR ADENOMA,SINGLE | X X | | HEPATOCELLULAR ADENOMA,THREE | X X | | HEPATOCELLULAR ADENOMA,TWO | X | | HEPATOCELLULAR CARCINOMA,SINGLE | X X | | HEPATOCELLULAR CARCINOMA,THREE | X X | | HEPATOCELLULAR CARCINOMA,TWO | X | | LYMPHOMA MALIGNANT | X X | | MESENTERY | + | | LYMPHOMA MALIGNANT | X | | PANCREAS | + + M + + + + + | | LYMPHOMA MALIGNANT | X | | NEOPLASM NOS | X | | SALIVARY GLANDS | + + + A + + + + | | STOMACH | + + + + + + + + | | STOMACH,FORESTOMACH | + + + + + + + + | | STOMACH,GLANDULAR | + + + + + + + + | | CARCINOMA,METASTATIC,LIVER | X | | TONGUE | + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 18 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:04.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 5| 5| 8| 2| 2| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 2| 2| 1| 8| 9| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| S M| | 0| 6| 6| 7| 7| 7| 8| 9| 0| 0| 0| 0| 0| 0| 5| 6| 9| 9| 9| 9| 0| 0| 0| 0| 6| U O| 50 MG/KGA 2YR 3 3 | 5| 5| 9| 2| 3| 8| 1| 9| 0| 1| 2| 3| 4| 5| 4| 9| 6| 7| 8| 9| 0| 1| 2| 3| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | CARDIOVASCULAR SYSTEM HEART | + + + + + + + + | | CARCINOMA,METASTATIC,LIVER | X | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + | | CARCINOMA,METASTATIC,LIVER | X | | ADRENAL GLAND,CORTEX | + + + + + + + + | | ADRENAL GLAND,MEDULLA | + + + + + + + + | | ISLETS, PANCREATIC | + + M + + + + + | | PARATHYROID GLAND | M M M + + + M + | | PITUITARY GLAND | + + + + + M M + | | ADENOMA,PARS DISTALIS | | | THYROID GLAND | + + + + + + M + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + M A + + + + + | | CARCINOMA,METASTATIC,LIVER | X | | LYMPHOMA MALIGNANT | X | | EPIDIDYMIS | + + + A + + + + + | | CARCINOMA,METASTATIC,LIVER | X | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X | | PREPUTIAL GLAND | + + + M + + + + + + | | PROSTATE | + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | SEMINAL VESICLE | + + + M + + + + + | | CARCINOMA,METASTATIC,LIVER | X | | LYMPHOMA MALIGNANT | X X | | TESTES | + + + A + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 19 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:04.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 5| 5| 8| 2| 2| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 2| 2| 1| 8| 9| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| S M| | 0| 6| 6| 7| 7| 7| 8| 9| 0| 0| 0| 0| 0| 0| 5| 6| 9| 9| 9| 9| 0| 0| 0| 0| 6| U O| 50 MG/KGA 2YR 3 3 | 5| 5| 9| 2| 3| 8| 1| 9| 0| 1| 2| 3| 4| 5| 4| 9| 6| 7| 8| 9| 0| 1| 2| 3| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + | | LYMPH NODE | + + + + + + + + + + + + | | SARCOMA,METASTATIC,UNCERTAIN PRIMARY SITE | | | LYMPH NODE,MANDIBULAR | + + + A + + + + | | LYMPHOMA MALIGNANT | X X X | | LYMPH NODE,MESENTERIC | + + + + + + + + + + + + | | CARCINOMA,METASTATIC,LIVER | X | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | X X X X | | SPLEEN | + + + + + A + + + + + | | HEMANGIOSARCOMA | | | LYMPHOMA MALIGNANT | X X X | | THYMUS | + M + M M + M M | | CARCINOMA,METASTATIC,LIVER | X | | LYMPHOMA MALIGNANT | X X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M M M M M M | | SKIN | + M + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + | | BONE,FEMUR | + + + + + + + + | | BONE,STERNUM | + + + + + + + + | | SKELETAL MUSCLE | + + + + + + + + | | CARCINOMA,METASTATIC,LIVER | X | | LYMPHOMA MALIGNANT | X | | RHABDOMYOSARCOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + A + + + + | | BRAIN,CEREBELLUM | + + + A + + + + | | BRAIN,CEREBRUM | + + + A + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 20 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:04.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 5| 5| 8| 2| 2| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 2| 2| 1| 8| 9| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| S M| | 0| 6| 6| 7| 7| 7| 8| 9| 0| 0| 0| 0| 0| 0| 5| 6| 9| 9| 9| 9| 0| 0| 0| 0| 6| U O| 50 MG/KGA 2YR 3 3 | 5| 5| 9| 2| 3| 8| 1| 9| 0| 1| 2| 3| 4| 5| 4| 9| 6| 7| 8| 9| 0| 1| 2| 3| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | NERVOUS SYSTEM LYMPHOMA MALIGNANT | X | | PERIPHERAL NERVE | + + + + + + + + | | SPINAL CORD | + + + A + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + | | LUNG | + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X | | ALVEOLAR/BRONCHIOLAR ADENOMA,TWO | | | ALVEOLAR/BRONCHIOLAR CARCINOMA | | | CARCINOMA,METASTATIC,LIVER | X | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER,| X X | | MULTIPLE | | | LYMPHOMA MALIGNANT | X X | | NOSE | + + + + + + + + | | CARCINOMA | | | TRACHEA | + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + | | HARDERIAN GLAND | + + + + + + + + + | | ADENOMA | X | | LYMPHOMA MALIGNANT,BILATERAL | X | | LACRIMAL GLAND | + + + A + + + + | | ZYMBAL'S GLAND | + + M + + + M + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | URINARY BLADDER | + + + + + + + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 21 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:06.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 2| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 8| 9| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| S M| | 6| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 9| 0| 0| 0| 0| 0| 0| U O| 50 MG/KGA 2YR 3 3 | 7| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + A + + | 11 | GALLBLADDER | A A + + | 10 | INTESTINE LARGE | A A + + | 4 | INTESTINE LARGE,CECUM | A A + + | 4 | INTESTINE LARGE,COLON | A A + + | 4 | INTESTINE LARGE,RECTUM | A A + + | 4 | INTESTINE SMALL | A A + + | 5 | INTESTINE SMALL,DUODENUM | A A + + | 4 | INTESTINE SMALL,ILEUM | A A + + | 5 | LYMPHOMA MALIGNANT | | 1| INTESTINE SMALL,JEJUNUM | A A + + | 4 | LIVER | + A + + + + + + + + + + + + + + + + + + + + + | 47 | CARCINOMA,BILE DUCT | | 1| HEPATOCELLULAR ADENOMA,MULTIPLE | | 1| HEPATOCELLULAR ADENOMA,SINGLE | X X X X X X X | 9| HEPATOCELLULAR ADENOMA,THREE | | 2| HEPATOCELLULAR ADENOMA,TWO | X X X X | 5| HEPATOCELLULAR CARCINOMA,SINGLE | X X X X X | 7| HEPATOCELLULAR CARCINOMA,THREE | | 2| HEPATOCELLULAR CARCINOMA,TWO | | 1| LYMPHOMA MALIGNANT | | 2| MESENTERY | | 1 | LYMPHOMA MALIGNANT | | 1| PANCREAS | A A + + | 9 | LYMPHOMA MALIGNANT | | 1| NEOPLASM NOS | | 1| SALIVARY GLANDS | + A + + | 10 | STOMACH | A A + + | 10 | STOMACH,FORESTOMACH | A A + + | 10 | STOMACH,GLANDULAR | A A + + | 10 | CARCINOMA,METASTATIC,LIVER | | 1| TONGUE | + A + + | 11 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + A + + | 11 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 22 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:06.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 2| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 8| 9| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| S M| | 6| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 9| 0| 0| 0| 0| 0| 0| U O| 50 MG/KGA 2YR 3 3 | 7| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | CARDIOVASCULAR SYSTEM HEART | + A + + | 11 | CARCINOMA,METASTATIC,LIVER | | 1| LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | A A + + | 10 | CARCINOMA,METASTATIC,LIVER | | 1| ADRENAL GLAND,CORTEX | A A + + | 10 | ADRENAL GLAND,MEDULLA | A A + + | 10 | ISLETS, PANCREATIC | + + + + | 11 | PARATHYROID GLAND | + A M + | 6 | PITUITARY GLAND | A A + + + | 9 | ADENOMA,PARS DISTALIS | X | 1| THYROID GLAND | + A + + | 10 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + A + + | 10 | CARCINOMA,METASTATIC,LIVER | | 1| LYMPHOMA MALIGNANT | | 1| EPIDIDYMIS | + A + + | 11 | CARCINOMA,METASTATIC,LIVER | | 1| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | | 2| PREPUTIAL GLAND | + A A + | 11 | PROSTATE | + A + + | 11 | LYMPHOMA MALIGNANT | | 2| SEMINAL VESICLE | + A + + + + + | 14 | CARCINOMA,METASTATIC,LIVER | | 1| LYMPHOMA MALIGNANT | | 2| TESTES | + A + + | 10 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 23 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:06.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 2| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 8| 9| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| S M| | 6| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 9| 0| 0| 0| 0| 0| 0| U O| 50 MG/KGA 2YR 3 3 | 7| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM BONE MARROW | A A + + | 10 | LYMPH NODE | A A + + + + + | 17 | SARCOMA,METASTATIC,UNCERTAIN PRIMARY SITE | X | 1| LYMPH NODE,MANDIBULAR | M A + + | 9 | LYMPHOMA MALIGNANT | | 3| LYMPH NODE,MESENTERIC | A A + + + + | 16 | CARCINOMA,METASTATIC,LIVER | | 1| HISTIOCYTIC SARCOMA | X | 1| LYMPHOMA MALIGNANT | | 4| SPLEEN | A + + + + + + + | 17 | HEMANGIOSARCOMA | X X | 2| LYMPHOMA MALIGNANT | | 3| THYMUS | M M M + | 4 | CARCINOMA,METASTATIC,LIVER | | 1| LYMPHOMA MALIGNANT | | 2| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M M | 0 | SKIN | + A + + | 10 | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + | 12 | BONE,FEMUR | + + + + | 12 | BONE,STERNUM | + + + + | 12 | SKELETAL MUSCLE | + A + + | 11 | CARCINOMA,METASTATIC,LIVER | | 1| LYMPHOMA MALIGNANT | | 1| RHABDOMYOSARCOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + A A + | 9 | BRAIN,CEREBELLUM | + A A + | 9 | BRAIN,CEREBRUM | + A A + | 9 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 24 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:06.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 2| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 8| 9| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| S M| | 6| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 9| 0| 0| 0| 0| 0| 0| U O| 50 MG/KGA 2YR 3 3 | 7| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | NERVOUS SYSTEM LYMPHOMA MALIGNANT | | 1| PERIPHERAL NERVE | + A + + | 11 | SPINAL CORD | + A A + | 9 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + A + + | 11 | LUNG | + A + + + + + | 16 | ALVEOLAR/BRONCHIOLAR ADENOMA | X | 3| ALVEOLAR/BRONCHIOLAR ADENOMA,TWO | X | 1| ALVEOLAR/BRONCHIOLAR CARCINOMA | X | 1| CARCINOMA,METASTATIC,LIVER | | 1| HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER,| | 2| MULTIPLE | | | LYMPHOMA MALIGNANT | | 2| NOSE | + + + + | 12 | CARCINOMA | X | 1| TRACHEA | + A + + | 11 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + A + + | 11 | HARDERIAN GLAND | + A + + | 12 | ADENOMA | X | 2| LYMPHOMA MALIGNANT,BILATERAL | | 1| LACRIMAL GLAND | + A + + | 10 | ZYMBAL'S GLAND | M A M + | 7 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | A A + + | 10 | LYMPHOMA MALIGNANT | | 2| URINARY BLADDER | + A + + | 11 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 25 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:16.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 2| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 8| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 6| 6| 7| 0| 0| 0| 0| 1| 1| 1| 1| 5| 5| 7| 7| 0| 0| 0| 0| 0| 0| 1| 1| 1| 6| U O| 100MG/KGA 2YR 4 4 | 2| 7| 1| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 0| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + + + | | GALLBLADDER | M + M + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X | | INTESTINE LARGE | + A + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE LARGE,CECUM | + A + + + + + + + + + + + + + + + + + + + + + + A | | LYMPHOMA MALIGNANT | X | | INTESTINE LARGE,COLON | + A + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE LARGE,RECTUM | M A + + + + + M + + + + + + + + + + + + + + M + A | | INTESTINE SMALL | + A + + + + + + + + + + + + + + + + + + + + + + A | | LYMPHOMA MALIGNANT | X | | INTESTINE SMALL,DUODENUM | + A + + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE SMALL,ILEUM | + A + + + + + + + + + + + + + + + + + + + + + + A | | ADENOCARCINOMA | | | LYMPHOMA MALIGNANT | X X | | INTESTINE SMALL,JEJUNUM | + A + + + + + + + + + + + + + + + + + + + + + + A | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA,SINGLE | X X X X X X | | HEPATOCELLULAR ADENOMA,THREE | | | HEPATOCELLULAR ADENOMA,TWO | X X X | | HEPATOCELLULAR CARCINOMA,SINGLE | X X X X X | | HEPATOCELLULAR CARCINOMA,TWO | X | | HISTIOCYTIC SARCOMA | X | | PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + + + | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | STOMACH | + A + + + + + + + + + + + + + + + + + + + + + + A | | STOMACH,FORESTOMACH | + A + + + + + + + + + + + + + + + + + + + + + + A | | STOMACH,GLANDULAR | + A + + + + + + + + + + + + + + + + + + + + + + A | | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + M + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER,| X | | AORTA | | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 26 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:16.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 2| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 8| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 6| 6| 7| 0| 0| 0| 0| 1| 1| 1| 1| 5| 5| 7| 7| 0| 0| 0| 0| 0| 0| 1| 1| 1| 6| U O| 100MG/KGA 2YR 4 4 | 2| 7| 1| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 0| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + + + M + + + + + | | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + + + M + + + + + | | ADRENAL GLAND,MEDULLA | + + + + + + + + + M + + + + + + + + + M + + + + + | | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | PARATHYROID GLAND | + + + + + + + + + + + + + + + + + M + M + + + + + | | PITUITARY GLAND | + M + + + + + + + + + + + + + + + + + + + + + + + | | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENERAL BODY SYSTEM TISSUE NOS | + + | | HEMANGIOSARCOMA | X | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER,| X | | MEDIASTINUM | | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | EPIDIDYMIS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT,UNILATERAL | X | | SCHWANNOMA BENIGN | X | | PENIS | + | | PREPUTIAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | PROSTATE | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X | | SEMINAL VESICLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TESTES | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA,INTERSTITIAL CELL | | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT,INGUINAL | X | | LYMPH NODE,MANDIBULAR | + M + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 27 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:17.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 2| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 8| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 6| 6| 7| 0| 0| 0| 0| 1| 1| 1| 1| 5| 5| 7| 7| 0| 0| 0| 0| 0| 0| 1| 1| 1| 6| U O| 100MG/KGA 2YR 4 4 | 2| 7| 1| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 0| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM HEMANGIOSARCOMA | X | | LYMPHOMA MALIGNANT | X X X | | SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | LYMPHOMA MALIGNANT | X X | | THYMUS | + + M + + M + M + + + M + + M + + + + + + + + + + | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M + M + M M M M M M M M M M M M M M M M M M M M | | SKIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | KERATOACANTHOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + + + + + + + M + + + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 28 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:17.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 2| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 8| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 6| 6| 7| 0| 0| 0| 0| 1| 1| 1| 1| 5| 5| 7| 7| 0| 0| 0| 0| 0| 0| 1| 1| 1| 6| U O| 100MG/KGA 2YR 4 4 | 2| 7| 1| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 0| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM ALVEOLAR/BRONCHIOLAR ADENOMA,TWO | X | | ALVEOLAR/BRONCHIOLAR CARCINOMA | X X | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X X | | LYMPHOMA MALIGNANT | X | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT,UNILATERAL | | | HARDERIAN GLAND | + M + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | | | LACRIMAL GLAND | + M + + + + + M + + + + + + + + + + + + + + + + + | | ZYMBAL'S GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 29 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:25.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 5| 7| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| U O| 100MG/KGA 2YR 4 4 | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | GALLBLADDER | + + + + + + + + + + + M M + + + + + + + + + + | 44 | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | | 1| INTESTINE LARGE | + + + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE LARGE,CECUM | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| INTESTINE LARGE,COLON | + + + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE LARGE,RECTUM | + + + + + + + + + + + + + + + + + + + + + + + | 43 | INTESTINE SMALL | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | | 1| INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE SMALL,ILEUM | + + + + + + + + + + + + + + + + + + + + + + + | 46 | ADENOCARCINOMA | X | 1| LYMPHOMA MALIGNANT | | 2| INTESTINE SMALL,JEJUNUM | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA,SINGLE | X X X X | 10| HEPATOCELLULAR ADENOMA,THREE | X | 1| HEPATOCELLULAR ADENOMA,TWO | X X X | 6| HEPATOCELLULAR CARCINOMA,SINGLE | X | 6| HEPATOCELLULAR CARCINOMA,TWO | | 1| HISTIOCYTIC SARCOMA | | 1| PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| STOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 46 | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + + + + + + + + + | 46 | STOMACH,GLANDULAR | + + + + + + + + + + + + + + + + + + + + + + + | 46 | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER,| | 1| AORTA | | | HEART | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | | 2| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 30 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:25.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 5| 7| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| U O| 100MG/KGA 2YR 4 4 | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + M + + + + + + + + + + + | 46 | ADRENAL GLAND,CORTEX | + + + + + + + + + + + M + + + + + + + + + + + | 46 | ADRENAL GLAND,MEDULLA | + + + + + + + + + + + M + + + + + + + + + + + | 45 | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PARATHYROID GLAND | + + + M M + + + + + M + + + M + + + + + + + + | 42 | PITUITARY GLAND | + + + + + + + + + + + + + + + + + + + + + M + | 46 | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ GENERAL BODY SYSTEM TISSUE NOS | | 2 | HEMANGIOSARCOMA | | 1| HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER,| | 1| MEDIASTINUM | | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | EPIDIDYMIS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT,UNILATERAL | | 1| SCHWANNOMA BENIGN | | 1| PENIS | | 1 | PREPUTIAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PROSTATE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | | 1| SEMINAL VESICLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | TESTES | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ADENOMA,INTERSTITIAL CELL | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT,INGUINAL | | 1| LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + M M + + + + + + + + | 45 | LYMPHOMA MALIGNANT | X | 3| LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 31 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:25.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 5| 7| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| U O| 100MG/KGA 2YR 4 4 | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM HEMANGIOSARCOMA | | 1| LYMPHOMA MALIGNANT | X | 4| SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA | X | 2| LYMPHOMA MALIGNANT | X | 3| THYMUS | + M + M + + + M + M + M + + M + + + M + + M + | 35 | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | | 1| LYMPHOMA MALIGNANT | X | 2| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M M M M M M M M M M M M M M M M M M M M M | 2 | SKIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | KERATOACANTHOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA | | 1| SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + + + + + + + + + | 47 | LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X X X | 9| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 32 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:25.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 5| 7| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| U O| 100MG/KGA 2YR 4 4 | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM ALVEOLAR/BRONCHIOLAR ADENOMA,TWO | X | 2| ALVEOLAR/BRONCHIOLAR CARCINOMA | X | 3| HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | | 2| LYMPHOMA MALIGNANT | X | 2| NOSE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT,UNILATERAL | X | 1| HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ADENOMA | X X X X X | 5| LACRIMAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 46 | ZYMBAL'S GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 33 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:26.2 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | 2| 2| 2| 4| 4| 4| 2| 2| 2| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| S M| | 0| 1| 1| 3| 3| 3| 1| 1| 1| 3| 3| 3| U O| CONTROL A 64WK 5 5 | 9| 0| 1| 4| 5| 6| 1| 2| 3| 5| 6| 7| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM LIVER | + + + + + + + + + + + + | 12 | HEPATOCELLULAR ADENOMA,SINGLE | X X | 2| LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 34 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:26.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | 2| 2| 2| 4| 4| 4| 2| 2| 2| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| S M| | 1| 1| 1| 3| 3| 3| 1| 1| 1| 3| 3| 4| U O| 25MG/KG A 64W 6 6 | 2| 3| 4| 7| 8| 9| 4| 5| 6| 8| 9| 0| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM LIVER | + + + + + + + + + + + + | 12 | HEPATOCELLULAR ADENOMA,SINGLE | X X | 2| HEPATOCELLULAR CARCINOMA,SINGLE | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 35 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:26.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | 2| 2| 2| 4| 4| 4| 2| 2| 2| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| S M| | 1| 1| 1| 4| 4| 4| 1| 1| 1| 4| 4| 4| U O| 50 MG/KGA 64W 7 7 | 5| 6| 7| 0| 1| 2| 7| 8| 9| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM LIVER | + + + + + + + + + + + + | 12 | HEPATOCELLULAR ADENOMA,SINGLE | X X | 2| HEPATOCELLULAR ADENOMA,TWO | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 36 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:27.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | 2| 2| 2| 4| 4| 4| 2| 2| 2| 4| 4| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| S M| | 1| 1| 2| 4| 4| 4| 2| 2| 2| 4| 4| 4| U O| 100MG/KGA 64W 8 8 | 8| 9| 0| 3| 4| 5| 0| 1| 2| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM LIVER | + + + + + + + + + + + + | 12 | HEPATOCELLULAR ADENOMA,SINGLE | X | 1| HEPATOCELLULAR CARCINOMA,SINGLE | X X | 2| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 37 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:33.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| | 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 5| 5| 7| 7| 1| 1| 1| 1| 1| 1| 1| 2| 2| 0| U O| CONTROL R 2YR 10 10 | 0| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 8| 2| 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + M + + + + + + | | GALLBLADDER | + + M + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE LARGE | + + + + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE LARGE,CECUM | + + + + + + + + + + + M M + + + + + + + + + + + + | | INTESTINE LARGE,COLON | + + + + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE LARGE,RECTUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE SMALL | + + + + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE SMALL,DUODENUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | X | | INTESTINE SMALL,ILEUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | INTESTINE SMALL,JEJUNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA,SINGLE | X X X X | | HEPATOCELLULAR ADENOMA,TWO | | | HEPATOCELLULAR CARCINOMA,SINGLE | X | | HISTIOCYTIC SARCOMA | X X | | LYMPHOMA MALIGNANT | | | PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + + | | STOMACH | + + + + + + + + + + + + + + + + + + + + + + + + + | | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + + + + + + + + + + + | | STOMACH,GLANDULAR | + + + + + + + + + + + + + + + + + + + + + + + + + | | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + M + + + + + + + + + + + + + + + + + | | ADRENAL GLAND,CORTEX | + + + + + + + M + + + + + + + + + + + + + + + + + | | ADRENAL GLAND,MEDULLA | + + + + + + + M + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 38 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:33.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| | 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 5| 5| 7| 7| 1| 1| 1| 1| 1| 1| 1| 2| 2| 0| U O| CONTROL R 2YR 10 10 | 0| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 8| 2| 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | PARATHYROID GLAND | + + + + + + + + + + + + M + + + + + M + + + + M M | | PITUITARY GLAND | + + + M + + + + + + + + + + + + + + + + M + + + + | | THYROID GLAND | + + + + + + + + + + + + + + + + + + M + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | EPIDIDYMIS | + + + + + + + + + + + + + + + + + + + + + + + + + | | PREPUTIAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | PROSTATE | + + + + + + + + + + + + + + + + + + + + + + + + M | | SEMINAL VESICLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TESTES | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT,LUMBAR | X | | LYMPH NODE,MANDIBULAR | + + + M + + + + + + + + + + + + + + + + + + + + + | | LYMPH NODE,MESENTERIC | M + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | X X | | SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | LYMPHOMA MALIGNANT | X X X | | THYMUS | + + M + + + + + + + + M M + + + + + + + + + + M M | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M M M M M M M M M M M M M M M M M M M M M M M | | SKIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 39 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:33.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| | 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 5| 5| 7| 7| 1| 1| 1| 1| 1| 1| 1| 2| 2| 0| U O| CONTROL R 2YR 10 10 | 0| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 8| 2| 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + + + + M + + + + + M | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X X X X | | ALVEOLAR/BRONCHIOLAR CARCINOMA | | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X | | NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TRACHEA | + + + + + + + + + + + + + + + + + + M + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + + + | | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | X X | | LACRIMAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ZYMBAL'S GLAND | M + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + + + | | URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 40 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:33.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| | 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 9| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 5| 5| 7| 7| 1| 1| 1| 1| 1| 1| 1| 2| 2| 0| U O| CONTROL R 2YR 10 10 | 0| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 8| 2| 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 41 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:39.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 1| 1| 2| 2| 2| 2| 2| 2| 2| 6| 6| 7| 7| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| U O| CONTROL R 2YR 10 10 | 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + | 47 | GALLBLADDER | A + + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE LARGE | A + + + + + + + + + + + + + + + + + + + + + + | 47 | INTESTINE LARGE,CECUM | A + + + + + + + + + + + + + + + + + + + + + + | 45 | INTESTINE LARGE,COLON | A + + + + + + + + + + + + + + + + + + + + + + | 47 | INTESTINE LARGE,RECTUM | A + + + + + + + + + + + + + + + + + + + + + + | 47 | INTESTINE SMALL | + + + + + + + + + + + + + + + + + + + + + + + | 48 | INTESTINE SMALL,DUODENUM | A + + + + + + + + + + + + + + + + + + + + + + | 47 | ADENOMA | | 1| INTESTINE SMALL,ILEUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| INTESTINE SMALL,JEJUNUM | A + + + + + + + + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT | | 1| LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA,SINGLE | X X X | 7| HEPATOCELLULAR ADENOMA,TWO | X X | 2| HEPATOCELLULAR CARCINOMA,SINGLE | X | 2| HISTIOCYTIC SARCOMA | | 2| LYMPHOMA MALIGNANT | X | 1| PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | STOMACH | A + + + + + + + + + + + + + + + + + + + + + + | 47 | STOMACH,FORESTOMACH | A + + + + + + + + + + + + + + + + + + + + + + | 47 | STOMACH,GLANDULAR | A + + + + + + + + + + + + + + + + + + + + + + | 47 | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEART | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | A + + + + + + + + + + + + + + + + M + + + + + | 45 | ADRENAL GLAND,CORTEX | A + + + + + + + + + + + + + + + + M + + + + + | 45 | ADRENAL GLAND,MEDULLA | A + + + + + + + + + + + + + + + + M + + + + + | 45 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 42 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:39.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 1| 1| 2| 2| 2| 2| 2| 2| 2| 6| 6| 7| 7| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| U O| CONTROL R 2YR 10 10 | 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PARATHYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 44 | PITUITARY GLAND | A + + + + + + + + + + M + + + + + M + + + + + | 43 | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | EPIDIDYMIS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PREPUTIAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PROSTATE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | SEMINAL VESICLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | TESTES | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPH NODE | + + + + + + + M + + + + + + + + + + + + + + + | 47 | LYMPHOMA MALIGNANT,LUMBAR | | 1| LYMPH NODE,MANDIBULAR | + + + + + + + M + + + + + + + + + + + + + + + | 46 | LYMPH NODE,MESENTERIC | + + + + + M M M + + + + + + + + + + + + + + + | 44 | LYMPHOMA MALIGNANT | X | 3| SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA | | 1| LYMPHOMA MALIGNANT | X X X | 6| THYMUS | M + + M + + + + M + + + + M + + + + + + + + + | 39 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M M M M M M M M M M M M M M M M M M M M M | 0 | SKIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 43 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:39.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 1| 1| 2| 2| 2| 2| 2| 2| 2| 6| 6| 7| 7| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| U O| CONTROL R 2YR 10 10 | 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X | 9| ALVEOLAR/BRONCHIOLAR CARCINOMA | X X | 2| HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X | 2| NOSE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ADENOMA | X X | 4| LACRIMAL GLAND | + + + + + + M + + + + + + + + + + + + + + + + | 47 | ZYMBAL'S GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + | 48 | URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 44 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:39.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 1| 1| 2| 2| 2| 2| 2| 2| 2| 6| 6| 7| 7| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| U O| CONTROL R 2YR 10 10 | 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 45 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:40.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 8| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| | 4| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 0| 6| 2| 2| 2| 2| 2| 2| 3| 3| 3| 5| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 6| U O| 25MG/KG R 2YR 11 11 | 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + | | GALLBLADDER | + + + | | INTESTINE LARGE | + + + | | INTESTINE LARGE,CECUM | + + + | | INTESTINE LARGE,COLON | + + + | | HISTIOCYTIC SARCOMA | X | | INTESTINE LARGE,RECTUM | + + + | | INTESTINE SMALL | + + + + | | INTESTINE SMALL,DUODENUM | + + + | | HEMANGIOSARCOMA | | | INTESTINE SMALL,ILEUM | + + + | | HISTIOCYTIC SARCOMA | X | | INTESTINE SMALL,JEJUNUM | + + + + | | LYMPHOMA MALIGNANT | X X | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA,SINGLE | X X X X X X X | | HEPATOCELLULAR CARCINOMA,SINGLE | X | | HEPATOCELLULAR CARCINOMA,TWO | | | HISTIOCYTIC SARCOMA | X | | LEUKEMIA GRANULOCYTIC | | | LYMPHOMA MALIGNANT | X | | PANCREAS | + + + | | SALIVARY GLANDS | + + + | | STOMACH | + + + | | STOMACH,FORESTOMACH | + + + | | STOMACH,GLANDULAR | + + + | | TONGUE | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + | | LYMPHOMA MALIGNANT | X | | HEART | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 46 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:40.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 8| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| | 4| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 0| 6| 2| 2| 2| 2| 2| 2| 3| 3| 3| 5| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 6| U O| 25MG/KG R 2YR 11 11 | 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + | | ADRENAL GLAND,CORTEX | + + + | | ADRENAL GLAND,MEDULLA | + + + | | ISLETS, PANCREATIC | + + + | | PARATHYROID GLAND | + + + | | PITUITARY GLAND | + M + | | ADENOMA,PARS DISTALIS | | | THYROID GLAND | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + | | EPIDIDYMIS | + + + | | PREPUTIAL GLAND | + + + | | PROSTATE | + + + | | HISTIOCYTIC SARCOMA | X | | SEMINAL VESICLE | + + + | | TESTES | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + | | LYMPH NODE | + + + + + | | HISTIOCYTIC SARCOMA,RENAL | X | | LYMPHOMA MALIGNANT,RENAL | X | | LYMPH NODE,MANDIBULAR | + M + | | LYMPH NODE,MESENTERIC | + + + + + | | HISTIOCYTIC SARCOMA | X | | LYMPHOMA MALIGNANT | X X X | | SPLEEN | + + + M | | LEUKEMIA GRANULOCYTIC | | | LYMPHOMA MALIGNANT | X | | THYMUS | M + + | | LYMPHOMA MALIGNANT | X | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 47 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:41.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 8| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| | 4| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 0| 6| 2| 2| 2| 2| 2| 2| 3| 3| 3| 5| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 6| U O| 25MG/KG R 2YR 11 11 | 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M | | SKIN | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + | | BONE,FEMUR | + + + | | BONE,STERNUM | + + + | | SKELETAL MUSCLE | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + | | BRAIN,CEREBELLUM | + + + | | BRAIN,CEREBRUM | + + + | | PERIPHERAL NERVE | + + + | | SPINAL CORD | M + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + | | LUNG | + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X | | CARCINOMA,METASTATIC,HARDERIAN GLAND | | | LYMPHOMA MALIGNANT | X | | NOSE | + + + | | TRACHEA | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EAR | + | | FIBROUS HISTIOCYTOMA | X | | EYE | + + + | | HARDERIAN GLAND | + + + + | | ADENOMA | X | | CARCINOMA | | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 48 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:41.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 8| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| | 4| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 0| 6| 2| 2| 2| 2| 2| 2| 3| 3| 3| 5| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 6| U O| 25MG/KG R 2YR 11 11 | 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM LACRIMAL GLAND | + + + | | ZYMBAL'S GLAND | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + | | URINARY BLADDER | + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 49 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:41.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 7| 2| 2| 2| 3| 3| 3| 3| 3| 3| 6| 6| 7| 7| 2| 2| 2| 3| 3| 3| 3| 3| 3| U O| 25MG/KG R 2YR 11 11 | 2| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 6| 7| 7| 8| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + | 4 | GALLBLADDER | + | 4 | INTESTINE LARGE | + | 4 | INTESTINE LARGE,CECUM | + | 4 | INTESTINE LARGE,COLON | + | 4 | HISTIOCYTIC SARCOMA | | 1| INTESTINE LARGE,RECTUM | + | 4 | INTESTINE SMALL | + | 5 | INTESTINE SMALL,DUODENUM | + | 4 | HEMANGIOSARCOMA | X | 1| INTESTINE SMALL,ILEUM | + | 4 | HISTIOCYTIC SARCOMA | | 1| INTESTINE SMALL,JEJUNUM | + | 5 | LYMPHOMA MALIGNANT | | 2| LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA,SINGLE | | 7| HEPATOCELLULAR CARCINOMA,SINGLE | X X | 3| HEPATOCELLULAR CARCINOMA,TWO | X X | 2| HISTIOCYTIC SARCOMA | | 1| LEUKEMIA GRANULOCYTIC | X | 1| LYMPHOMA MALIGNANT | | 1| PANCREAS | + | 4 | SALIVARY GLANDS | + | 4 | STOMACH | + + | 5 | STOMACH,FORESTOMACH | + + | 5 | STOMACH,GLANDULAR | + + | 5 | TONGUE | + | 4 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + | 4 | LYMPHOMA MALIGNANT | | 1| HEART | + | 4 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 50 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:41.8 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 7| 2| 2| 2| 3| 3| 3| 3| 3| 3| 6| 6| 7| 7| 2| 2| 2| 3| 3| 3| 3| 3| 3| U O| 25MG/KG R 2YR 11 11 | 2| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 6| 7| 7| 8| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + | 4 | ADRENAL GLAND,CORTEX | + | 4 | ADRENAL GLAND,MEDULLA | + | 4 | ISLETS, PANCREATIC | + | 4 | PARATHYROID GLAND | M | 3 | PITUITARY GLAND | M + | 3 | ADENOMA,PARS DISTALIS | X | 1| THYROID GLAND | + | 4 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + | 4 | EPIDIDYMIS | + | 4 | PREPUTIAL GLAND | + | 4 | PROSTATE | + | 4 | HISTIOCYTIC SARCOMA | | 1| SEMINAL VESICLE | + | 4 | TESTES | + | 4 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + | 4 | LYMPH NODE | + + + | 8 | HISTIOCYTIC SARCOMA,RENAL | | 1| LYMPHOMA MALIGNANT,RENAL | | 1| LYMPH NODE,MANDIBULAR | + | 3 | LYMPH NODE,MESENTERIC | + + + | 8 | HISTIOCYTIC SARCOMA | | 1| LYMPHOMA MALIGNANT | X | 4| SPLEEN | + + + + + | 8 | LEUKEMIA GRANULOCYTIC | X | 1| LYMPHOMA MALIGNANT | X | 2| THYMUS | M | 2 | LYMPHOMA MALIGNANT | | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 51 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:41.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 7| 2| 2| 2| 3| 3| 3| 3| 3| 3| 6| 6| 7| 7| 2| 2| 2| 3| 3| 3| 3| 3| 3| U O| 25MG/KG R 2YR 11 11 | 2| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 6| 7| 7| 8| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | INTEGUMENTARY SYSTEM MAMMARY GLAND | M | 0 | SKIN | + | 4 | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + | 4 | BONE,FEMUR | + | 4 | BONE,STERNUM | + | 4 | SKELETAL MUSCLE | + | 4 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + | 4 | BRAIN,CEREBELLUM | + | 4 | BRAIN,CEREBRUM | + | 4 | PERIPHERAL NERVE | + | 4 | SPINAL CORD | + | 3 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + | 4 | LUNG | + + | 6 | ALVEOLAR/BRONCHIOLAR ADENOMA | | 1| CARCINOMA,METASTATIC,HARDERIAN GLAND | X | 1| LYMPHOMA MALIGNANT | | 1| NOSE | + | 4 | TRACHEA | + | 4 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EAR | | 1 | FIBROUS HISTIOCYTOMA | | 1| EYE | + | 4 | HARDERIAN GLAND | + + + + | 8 | ADENOMA | X X | 3| CARCINOMA | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 52 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:42.0 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 7| 2| 2| 2| 3| 3| 3| 3| 3| 3| 6| 6| 7| 7| 2| 2| 2| 3| 3| 3| 3| 3| 3| U O| 25MG/KG R 2YR 11 11 | 2| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 6| 7| 7| 8| 9| 0| 1| 2| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | SPECIAL SENSES SYSTEM LACRIMAL GLAND | + | 4 | ZYMBAL'S GLAND | M | 3 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + | 4 | URINARY BLADDER | + | 4 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 53 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:42.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| S M| | 0| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| U O| 50 MG/KGR 2YR 12 12 | 6| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 1| 2| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + | | GALLBLADDER | + | | INTESTINE LARGE | + | | INTESTINE LARGE,CECUM | + | | INTESTINE LARGE,COLON | + | | INTESTINE LARGE,RECTUM | + | | INTESTINE SMALL | + | | INTESTINE SMALL,DUODENUM | + | | INTESTINE SMALL,ILEUM | + | | INTESTINE SMALL,JEJUNUM | + | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEPATOCELLULAR ADENOMA,SINGLE | X X X X X X X | | HEPATOCELLULAR CARCINOMA,SINGLE | X | | HEPATOCELLULAR CARCINOMA,TWO | | | PANCREAS | + | | SALIVARY GLANDS | + | | STOMACH | + | | STOMACH,FORESTOMACH | + | | STOMACH,GLANDULAR | + | | TONGUE | + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + | | HEART | + | | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | + | | ADRENAL GLAND,CORTEX | + | | ADRENAL GLAND,MEDULLA | + | | ISLETS, PANCREATIC | + | | PARATHYROID GLAND | M | | PITUITARY GLAND | + | | THYROID GLAND | M | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 54 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:42.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| S M| | 0| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| U O| 50 MG/KGR 2YR 12 12 | 6| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 1| 2| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | GENITAL SYSTEM COAGULATING GLAND | + | | EPIDIDYMIS | + | | PREPUTIAL GLAND | + | | PROSTATE | + | | SEMINAL VESICLE | + | | TESTES | + | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + | | LYMPH NODE | + | | LYMPH NODE,MANDIBULAR | + | | LYMPH NODE,MESENTERIC | + | | LYMPHOMA MALIGNANT | | | SPLEEN | + | | HEMANGIOSARCOMA | | | LYMPHOMA MALIGNANT | | | THYMUS | + | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M | | SKIN | + | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + | | BONE,FEMUR | + | | BONE,STERNUM | + | | SKELETAL MUSCLE | + | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + | | BRAIN,CEREBELLUM | + | | BRAIN,CEREBRUM | + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 55 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:42.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| S M| | 0| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| U O| 50 MG/KGR 2YR 12 12 | 6| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 1| 2| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | NERVOUS SYSTEM PERIPHERAL NERVE | + | | SPINAL CORD | + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + | | LUNG | + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X | | NOSE | + | | TRACHEA | + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + | | HARDERIAN GLAND | + | | ADENOMA | | | LACRIMAL GLAND | + | | ZYMBAL'S GLAND | + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + | | URINARY BLADDER | + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 56 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:43.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 7| 7| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| U O| 50 MG/KGR 2YR 12 12 | 7| 8| 9| 0| 1| 2| 3| 4| 5| 4| 5| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | | 1 | GALLBLADDER | | 1 | INTESTINE LARGE | | 1 | INTESTINE LARGE,CECUM | | 1 | INTESTINE LARGE,COLON | | 1 | INTESTINE LARGE,RECTUM | | 1 | INTESTINE SMALL | | 1 | INTESTINE SMALL,DUODENUM | | 1 | INTESTINE SMALL,ILEUM | | 1 | INTESTINE SMALL,JEJUNUM | | 1 | LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEPATOCELLULAR ADENOMA,SINGLE | X X X | 10| HEPATOCELLULAR CARCINOMA,SINGLE | X X | 3| HEPATOCELLULAR CARCINOMA,TWO | X | 1| PANCREAS | | 1 | SALIVARY GLANDS | | 1 | STOMACH | | 1 | STOMACH,FORESTOMACH | | 1 | STOMACH,GLANDULAR | | 1 | TONGUE | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | | 1 | HEART | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ ENDOCRINE SYSTEM ADRENAL GLAND | | 1 | ADRENAL GLAND,CORTEX | | 1 | ADRENAL GLAND,MEDULLA | | 1 | ISLETS, PANCREATIC | | 1 | PARATHYROID GLAND | | 0 | PITUITARY GLAND | | 1 | THYROID GLAND | | 0 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 57 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:43.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 7| 7| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| U O| 50 MG/KGR 2YR 12 12 | 7| 8| 9| 0| 1| 2| 3| 4| 5| 4| 5| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | GENITAL SYSTEM COAGULATING GLAND | | 1 | EPIDIDYMIS | | 1 | PREPUTIAL GLAND | | 1 | PROSTATE | | 1 | SEMINAL VESICLE | | 1 | TESTES | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | | 1 | LYMPH NODE | + + | 3 | LYMPH NODE,MANDIBULAR | | 1 | LYMPH NODE,MESENTERIC | + + | 3 | LYMPHOMA MALIGNANT | X | 1| SPLEEN | + + + | 4 | HEMANGIOSARCOMA | X | 1| LYMPHOMA MALIGNANT | X | 1| THYMUS | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | | 0 | SKIN | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | | 1 | BONE,FEMUR | | 1 | BONE,STERNUM | | 1 | SKELETAL MUSCLE | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | | 1 | BRAIN,CEREBELLUM | | 1 | BRAIN,CEREBRUM | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 58 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:43.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 7| 7| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| U O| 50 MG/KGR 2YR 12 12 | 7| 8| 9| 0| 1| 2| 3| 4| 5| 4| 5| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 4| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | NERVOUS SYSTEM PERIPHERAL NERVE | | 1 | SPINAL CORD | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | | 1 | LUNG | + + + | 5 | ALVEOLAR/BRONCHIOLAR ADENOMA | X X | 3| NOSE | | 1 | TRACHEA | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | | 1 | HARDERIAN GLAND | + | 2 | ADENOMA | X | 1| LACRIMAL GLAND | | 1 | ZYMBAL'S GLAND | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | | 1 | URINARY BLADDER | | 1 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 59 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:50.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 1| 8| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| | 1| 5| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 0| 2| 6| 7| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 6| U O| 100MG/KGR 2YR 13 13 | 4| 1| 1| 7| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + + + | | GALLBLADDER | + + A A + + + + + + + + + + + + + + + + + + + + + | | INTESTINE LARGE | + + + + + + + + + + + + + + + + + + + + + + + + + | | INTESTINE LARGE,CECUM | + + A A + + + + + + + + + + + + + + + + + + + + A | | INTESTINE LARGE,COLON | + + A + + + + + + + + + + + + + + + + + + + + + A | | INTESTINE LARGE,RECTUM | + + + A + + + + + + + + + + + + + + + + + + + + + | | INTESTINE SMALL | + + A A + + + + + + + + + + + + + + + + + + + + A | | INTESTINE SMALL,DUODENUM | + + A A + + + + + + + + + + + + + + + + + + + + A | | INTESTINE SMALL,ILEUM | + + A A + + + + + + + + + + + + + + + + + + + + A | | INTESTINE SMALL,JEJUNUM | + + A A + + + + + + + + + + + + + + + + + + + + A | | LIVER | + + + + + + + + + + + + + + + + + + + + + + + + + | | HEMANGIOSARCOMA | X | | HEPATOCELLULAR ADENOMA,SINGLE | X X X | | HEPATOCELLULAR ADENOMA,TWO | X | | HEPATOCELLULAR CARCINOMA,FOUR | | | HEPATOCELLULAR CARCINOMA,SINGLE | X X X | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | | | PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + + + | | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | STOMACH | + + + + + + + + + + + + + + + + + + + + + + + + + | | STOMACH,FORESTOMACH | + + + + + + + + + + + + + + + + + + + + + + + + + | | STOMACH,GLANDULAR | + + + + + + + + + + + + + + + + + + + + + + + + + | | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | | | HEART | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 60 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:50.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 1| 8| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| | 1| 5| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 0| 2| 6| 7| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 6| U O| 100MG/KGR 2YR 13 13 | 4| 1| 1| 7| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + M + + + + + + + + + + | | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + M + + + + + + + + + + | | ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + M + + + + + + + + + + | | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | PARATHYROID GLAND | + + + + + + + + + + + + + + + + + M + + + + + + + | | PITUITARY GLAND | M + M + + + M + M + + + + + + + M + + + + M M + M | | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | EPIDIDYMIS | + + + + + + + + + + + + + + + + + + + + + + + + + | | FIBROMA | | | LYMPHOMA MALIGNANT | | | PREPUTIAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | PROSTATE | + + + + + + + + + + + + + + M + + + + + M + + + + | | LYMPHOMA MALIGNANT | | | SEMINAL VESICLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TESTES | + + + + + + + + + + + + + + + + + + + + + + + + A | | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT,AXILLARY | | | LYMPHOMA MALIGNANT,INGUINAL | | | LYMPHOMA MALIGNANT,LUMBAR | | | LYMPHOMA MALIGNANT,POPLITEAL | | | LYMPHOMA MALIGNANT,RENAL | | | LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + + + | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | X X | | SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 61 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:50.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 1| 8| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| | 1| 5| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 0| 2| 6| 7| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 6| U O| 100MG/KGR 2YR 13 13 | 4| 1| 1| 7| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM HEMANGIOSARCOMA | X | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | X | | THYMUS | + M A M + + M + + + + M M + M + M + + + + + + + + | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | + M M M M M M M M M M M M M M M M M M M M M M M M | | SKIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + + + | | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + + + | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + + + | | BRAIN,CEREBRUM | M + + + + + + + + + + + + + + + + + + + + + + + + | | PERIPHERAL NERVE | + + + + + + + + + + + + + + + + + + + + + + + + + | | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + + + + + + + + + + + | | LUNG | + + + + + + + + + + + + + + + + + + + + + + + + + | | ALVEOLAR/BRONCHIOLAR ADENOMA | X X X | | CARCINOMA,METASTATIC,HARDERIAN GLAND | | | HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | X | | HISTIOCYTIC SARCOMA | | | LYMPHOMA MALIGNANT | | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 62 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:50.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 3| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | 1| 8| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| | 1| 5| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 4| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| S M| | 0| 2| 6| 7| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 6| U O| 100MG/KGR 2YR 13 13 | 4| 1| 1| 7| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 1| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM NOSE | + + + + + + + + + + + + + + + + + + + + + + + + + | | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | A + + + + + + + + + + + + + + + + + + + + + + + + | | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + + + | | ADENOMA | X X | | CARCINOMA | | | LACRIMAL GLAND | + + + + + + + + + + + + + + + + + + + + + + M M + | | LYMPHOMA MALIGNANT | | | ZYMBAL'S GLAND | + + M + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | + + + + + + + + + + + + + + + + + + + + + + + + + | | URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + + + | | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 63 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:57.3 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 8| 8| 4| 4| 4| 4| 4| 5| 5| 5| 5| U O| 100MG/KGR 2YR 13 13 | 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM ESOPHAGUS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | GALLBLADDER | A + + + + + + + + + + + + + M + + + + + M + + | 43 | INTESTINE LARGE | A + + + + + + + + + + + + + + + + + + + + + + | 47 | INTESTINE LARGE,CECUM | A + + + + + + + + + + + + + + + + + + + + + + | 44 | INTESTINE LARGE,COLON | A + + + + + + + + + + + + + + + + + + + + + + | 45 | INTESTINE LARGE,RECTUM | A + + + + + + + + + + + + + + + + + + + + + + | 46 | INTESTINE SMALL | A + + + + + + + + + + + + + + + + + + + + + + | 44 | INTESTINE SMALL,DUODENUM | A + + + + + + + + + + + + + + + + + + + + + + | 44 | INTESTINE SMALL,ILEUM | A + + + + + + + + + + + + + + + + + + + + + + | 44 | INTESTINE SMALL,JEJUNUM | A + + + + + + + + + + + + + + + + + + + + + + | 44 | LIVER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HEMANGIOSARCOMA | X | 2| HEPATOCELLULAR ADENOMA,SINGLE | X X X X X X | 9| HEPATOCELLULAR ADENOMA,TWO | | 1| HEPATOCELLULAR CARCINOMA,FOUR | X | 1| HEPATOCELLULAR CARCINOMA,SINGLE | X X X X | 7| HISTIOCYTIC SARCOMA | X X | 2| LYMPHOMA MALIGNANT | X X | 2| PANCREAS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SALIVARY GLANDS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| STOMACH | A + + + + + + + + + + + + + + + + + + + + + + | 47 | STOMACH,FORESTOMACH | A + + + + + + + + + + + + + + + + + + + + + + | 47 | STOMACH,GLANDULAR | A + + + + + + + + + + + + + + + + + + + + + + | 47 | TONGUE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ CARDIOVASCULAR SYSTEM BLOOD VESSEL | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | X | 1| LYMPHOMA MALIGNANT | X | 1| HEART | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | X | 1| LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 64 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:57.5 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 8| 8| 4| 4| 4| 4| 4| 5| 5| 5| 5| U O| 100MG/KGR 2YR 13 13 | 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ENDOCRINE SYSTEM ADRENAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ADRENAL GLAND,CORTEX | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ADRENAL GLAND,MEDULLA | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ISLETS, PANCREATIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | PARATHYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | PITUITARY GLAND | M + + + + + + + + + + + + + + + + M + + + + + | 38 | THYROID GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ GENITAL SYSTEM COAGULATING GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | EPIDIDYMIS | + + + + + + + + + + + + + + + + + + + + + + + | 48 | FIBROMA | X | 1| LYMPHOMA MALIGNANT | X | 1| PREPUTIAL GLAND | + + + + M + + + + + + + + + + + + + + + + + + | 47 | PROSTATE | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | X | 1| SEMINAL VESICLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | TESTES | A + + + + + + + + + + + + + + + + + + + + + + | 46 | ------------------------------------------------------------------------------------------------------------------------------------ HEMATOPOIETIC SYSTEM BONE MARROW | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| LYMPH NODE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT,AXILLARY | X | 1| LYMPHOMA MALIGNANT,INGUINAL | X | 1| LYMPHOMA MALIGNANT,LUMBAR | X | 1| LYMPHOMA MALIGNANT,POPLITEAL | X | 1| LYMPHOMA MALIGNANT,RENAL | X | 1| LYMPH NODE,MANDIBULAR | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| LYMPH NODE,MESENTERIC | + + + + + + + + + + + + + + + + + + + + + + + | 48 | HISTIOCYTIC SARCOMA | X X X | 3| LYMPHOMA MALIGNANT | X | 3| SPLEEN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 65 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:57.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 8| 8| 4| 4| 4| 4| 4| 5| 5| 5| 5| U O| 100MG/KGR 2YR 13 13 | 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | HEMATOPOIETIC SYSTEM HEMANGIOSARCOMA | | 1| HISTIOCYTIC SARCOMA | X X | 2| LYMPHOMA MALIGNANT | X | 2| THYMUS | + M M + M + + M + M M M M + + + M + + + + M + | 30 | LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM MAMMARY GLAND | M M M M M M M M M M M + M M M M M M M M M M M | 2 | SKIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ MUSCULOSKELETAL SYSTEM BONE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,FEMUR | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BONE,STERNUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | SKELETAL MUSCLE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ NERVOUS SYSTEM BRAIN | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBELLUM | + + + + + + + + + + + + + + + + + + + + + + + | 48 | BRAIN,CEREBRUM | + + + + + + + + + + + + + + + + + + + + + + + | 47 | PERIPHERAL NERVE | + + + + + + + + + + + + + + + M + + + + + + + | 47 | SPINAL CORD | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ RESPIRATORY SYSTEM LARYNX | + + + + + + + + + + + + + + + + + + + + + + + | 48 | LUNG | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ALVEOLAR/BRONCHIOLAR ADENOMA | X X | 5| CARCINOMA,METASTATIC,HARDERIAN GLAND | X | 1| HEPATOCELLULAR CARCINOMA,METASTATIC,LIVER | | 1| HISTIOCYTIC SARCOMA | X | 1| LYMPHOMA MALIGNANT | X | 1| ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 66 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:57.7 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| S M| | 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 8| 8| 4| 4| 4| 4| 4| 5| 5| 5| 5| U O| 100MG/KGR 2YR 13 13 | 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | RESPIRATORY SYSTEM NOSE | + + + + + + + + + + + + + + + + + + + + + + + | 48 | TRACHEA | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ SPECIAL SENSES SYSTEM EYE | + + + + + + + + + + + + + + + + + + + + + + + | 47 | HARDERIAN GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ADENOMA | X X | 4| CARCINOMA | X | 1| LACRIMAL GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 46 | LYMPHOMA MALIGNANT | X | 1| ZYMBAL'S GLAND | + + + + + + + + + + + + + + + + + + + + + + + | 47 | ------------------------------------------------------------------------------------------------------------------------------------ URINARY SYSTEM KIDNEY | A + + + + + + + + + + + + + + + + + + + + + + | 47 | URINARY BLADDER | + + + + + + + + + + + + + + + + + + + + + + + | 48 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 67 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:58.1 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | 3| 3| 3| 5| 5| 5| 3| 3| 3| 5| 5| 5| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| S M| | 2| 2| 2| 4| 4| 4| 2| 2| 2| 4| 4| 4| U O| CONTROL R 64W 14 14 | 2| 3| 4| 6| 7| 8| 3| 4| 5| 7| 8| 9| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM LIVER | + + + + + + + + + + + + | 12 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 68 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:58.4 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | 3| 3| 3| 5| 5| 5| 3| 3| 3| 5| 5| 5| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| S M| | 2| 2| 2| 4| 5| 5| 2| 2| 2| 5| 5| 5| U O| 25 MG/KGR 64W 15 15 | 5| 6| 7| 9| 0| 1| 6| 7| 8| 0| 1| 2| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM LIVER | + + + + + + + + + + + + | 12 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 69 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:58.6 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | 3| 3| 3| 5| 5| 5| 3| 3| 3| 5| 5| 5| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| S M| | 2| 2| 3| 5| 5| 5| 2| 3| 3| 5| 5| 5| U O| 50 MG/KGR 64W 16 16 | 8| 9| 0| 2| 3| 4| 9| 0| 1| 3| 4| 5| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM LIVER | + + + + + + + + + + + + | 12 | ------------------------------------------------------------------------------------------------------------------------------------ INTEGUMENTARY SYSTEM SKIN | + | 1 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED NCTR EXP/TEST: 211701 PAGE: 70 INDIVIDUAL ANIMAL TUMOR PATHOLOGY TABLE DATE: 02/15/2000 PATHOLOGY REPORT 3 TIME: 14:24:58.9 ---------------------------------------------------------------------------------------------------------------------------------- | DAYS ON | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | 3| 3| 3| 5| 5| 5| 3| 3| 3| 5| 5| 5| ------------------------------------------------------------------------------------------------------------------------ T | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| I T| Mice-C57Bl/6N XC3H/HEN MTN-NCTR | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| S U| MALE CARCASS ID | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| S M| | 3| 3| 3| 5| 5| 5| 3| 3| 3| 5| 5| 5| U O| 100MG/KGR 64W 17 17 | 1| 2| 3| 5| 6| 7| 2| 3| 4| 6| 7| 8| E R| ------------------------------------------------------------------------------------------------------------------------ S S| ---------------------------------------------------------------------------------------------------------------------------------- | ALIMENTARY SYSTEM LIVER | + + + + + + + + + + + + | 12 | ------------------------------------------------------------------------------------------------------------------------------------ + : TISSUE EXAMINED MICROSCOPICALLY M : MISSING TISSUE 1-4 : LESION QUALIFIED AS: X : LESION PRESENT BUT NOT QUALIFIED A : AUTOLYSIS PRECLUDES EXAMINATION 1) MINIMAL 3) MODERATE I : INSUFFICIENT TISSUE BLANK : NOT EXAMINED 2) MILD 4)MARKED