TDMS Study 05094-03 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
BUTYL BENZYL PHTHALATE
NTP Experiment-Test: 05094-03 Report: PEIRPT09
Study Type: CHRONIC Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
RESTRICTED CORE
Facility: Southern Research Institute
Chemical CAS #: 85-68-7
Lock Date: 11/25/92
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 UNTREATDCONTROL
Include 002 UNTREATDCONTROL
Include 003 1.2%
Include 004 2.4%
Page 1
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 6| 6| 7| 9| 8| 9| 9| 9| 9| 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9|
DAY ON TEST | 4| 9| 8| 0| 7| 4| 7| 1| 7| 6| 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7|
| 4| 4| 7| 2| 7| 4| 7| 4| 1| 7| 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | X X X X X 3 X X X X X X X X X X X|
Clear Cell Focus | 2 |
Developmental Malformation | X |
Eosinophilic Focus | X X |
Granuloma | 2 1 1 2 2 1 |
Hematopoietic Cell Proliferation | 2 2 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | |
Inflammation, Subacute | 2 |
Mixed Cell Focus | X X X 3 X |
Bile Duct, Hyperplasia | 2 1 2 1 1 1|
Centrilobular, Necrosis | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 3 |
Kupffer Cell, Pigmentation | 2 2 3 1|
Lobules, Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Accessory Spleen | X X |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 3 1 1 1 1 1 2 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + M + + + + + + + + + + + + + +|
Edema | 3 |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + M + + + + + + + + + + + + + +|
Erosion | 1 3 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 6| 6| 7| 9| 8| 9| 9| 9| 9| 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9|
DAY ON TEST | 4| 9| 8| 0| 7| 4| 7| 1| 7| 6| 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7|
| 4| 4| 7| 2| 7| 4| 7| 4| 1| 7| 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 3 2 2 2 1 1 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 X |
Angiectasis | 1 1 1 2 1 2 3 2 3 1 1 1 1 2 |
Degeneration, Fatty | 1 1 1 2 1 2 |
Hyperplasia, Focal | 1 1 1 1 |
Hypertrophy, Focal | 1 1 1 |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 3 2 1 4 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 3 3 3 |
Pars Distalis, Cyst | X X X X X 3|
Pars Distalis, Hyperplasia, Focal | 1 1 3 3 3 |
Pars Intermedia, Angiectasis | 3 2 |
Pars Intermedia, Cyst | 3 X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 1 1 1 1 1|
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 4 2 3 4 2 4 |
Hyperplasia | 2 2 2 |
Inflammation, Chronic | 2 2 2 |
Inflammation, Suppurative | 2 3 1 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Vagina | M + M M M M|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 6| 6| 7| 9| 8| 9| 9| 9| 9| 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9|
DAY ON TEST | 4| 9| 8| 0| 7| 4| 7| 1| 7| 6| 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7|
| 4| 4| 7| 2| 7| 4| 7| 4| 1| 7| 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 |
Myelofibrosis | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Iliac, Ectasia | 2 2 |
Iliac, Hyperplasia, Lymphoid | 3 3 |
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | 3 3 3|
Pancreatic, Pigmentation | 2 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 |
Hemorrhage | 1 2 |
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2|
Hematopoietic Cell Proliferation | 2 2 3 2 2 1 2 4 3 |
Pigmentation, Hemosiderin | 2 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Ectasia | 2 3 2 2 2 1 2 1 |
Galactocele | X |
Hyperplasia | 1 2 1 1 2 2 2 2 1 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | 3 |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 3 2 3 3 |
Femur, Osteopetrosis | 2 3 2 3 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 6| 6| 7| 9| 8| 9| 9| 9| 9| 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9|
DAY ON TEST | 4| 9| 8| 0| 7| 4| 7| 1| 7| 6| 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7|
| 4| 4| 7| 2| 7| 4| 7| 4| 1| 7| 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Compression | 3 4 4 |
Hemorrhage | 4 |
Hydrocephalus | 2 3 |
Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 2 1 1|
Inflammation, Subacute | 2 |
Alveolar Epithelium, Hyperplasia | 1 3 3 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 3 3 3 3 3 |
Foreign Body | 2 |
Fungus | 2 |
Mucosa, Hyperplasia | 1 2 1 |
Mucosa, Metaplasia, Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X|
Mineralization | 1 3 1 3 2 2 2 2 1 1 2 1 2 2 2 2 2 2 3 2 2 3 2 2|
Nephropathy | 1 1 1 2 1 1 2 1 1 2 1 1 2 1 1 1 1 1 1 1 1|
Renal Tubule, Hyperplasia | 1 |
Renal Tubule, Pigmentation | 3 1 1 1 2 1 1 3 1 2 1 2 1 1 2 2 2 1 1 1 2 2 1 2|
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9| |
DAY ON TEST | 5| 2| 1| 4| 1| 9| 2| 8| 9| 7| 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7| |
| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Edema | | 1 2.0|
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + I + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 2 | 4 2.5|
Basophilic Focus | X X X X X X X X X X X X X X X| 32 3.0|
Clear Cell Focus | X| 2 2.0|
Developmental Malformation | | 1 |
Eosinophilic Focus | X X X X X X| 8 |
Granuloma | 1 1 1 1 1| 11 1.3|
Hematopoietic Cell Proliferation | | 3 1.7|
Hemorrhage | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | X X | 2 |
Inflammation, Subacute | | 1 2.0|
Mixed Cell Focus | X X X X X X| 11 3.0|
Bile Duct, Hyperplasia | 1 2 2 2 1 2 3 | 13 1.6|
Centrilobular, Necrosis | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 4 3 | 6 3.0|
Kupffer Cell, Pigmentation | 2 2 2 2 3 | 9 2.1|
Lobules, Necrosis | 2 2 | 4 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Accessory Spleen | X | 3 |
Fat, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 1 4 2 1 2 2 1 2 1 1 2 1 | 25 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Edema | 2 | 2 2.5|
Mucosa, Hyperplasia | 2 3 2 | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9| |
DAY ON TEST | 5| 2| 1| 4| 1| 9| 2| 8| 9| 7| 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7| |
| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 1 1 3 1 2 3 1 2 1 2| 23 1.7|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 2 1 1 2 2 | 8 1.6|
Angiectasis | 1 1 2 1 1 1 2 1 2 2 2 1 1| 27 1.5|
Degeneration, Fatty | 1 3 1 1 3 2 1 3 1 1| 16 1.6|
Hyperplasia, Focal | 1 1 | 6 1.0|
Hypertrophy, Focal | 2 3 1 2 | 7 1.6|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + I + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 | 10 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + M + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 3 | 8 2.8|
Pars Distalis, Cyst | 3 3 3 3 | 10 3.0|
Pars Distalis, Hyperplasia, Focal | 3 3 2 3 | 9 2.4|
Pars Intermedia, Angiectasis | | 2 2.5|
Pars Intermedia, Cyst | X | 3 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 1 1 1 2 | 9 1.1|
Follicle, Cyst | 3 3 3| 4 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 3 2 4 2 3 3 3| 15 3.0|
Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9| |
DAY ON TEST | 5| 2| 1| 4| 1| 9| 2| 8| 9| 7| 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7| |
| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 | 4 2.0|
Inflammation, Suppurative | 3 2 2| 7 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X 3 X | 6 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | 2 | 2 2.0|
Hyperplasia, Cystic | 1 1 1 1 1| 7 1.0|
__________________________________________________________________________|____________|
Vagina | M M M M M | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | | 2 3.0|
Myelofibrosis | 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 21 |
Iliac, Ectasia | | 2 2.0|
Iliac, Hyperplasia, Lymphoid | | 2 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Pigmentation | 3 3 3 3 | 7 3.0|
Pancreatic, Pigmentation | 2 | 2 2.0|
Renal, Pigmentation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | | 3 2.0|
Hemorrhage | 3 2 2 2| 6 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | 2 2 2 2 2 2 2 3 2 2 3 2 | 19 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 2 3.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 3 3 3 | 6 2.5|
Hematopoietic Cell Proliferation | 3 2 2 2 | 13 2.3|
Pigmentation, Hemosiderin | 2 2 2 3 2 2 2 2 2 2 2 2| 18 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9| |
DAY ON TEST | 5| 2| 1| 4| 1| 9| 2| 8| 9| 7| 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7| |
| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Ectasia | 2 2 3 2 2 3 2 2 2 2 2 2 2 2| 22 2.0|
Galactocele | X | 2 |
Hyperplasia | 2 1 1 2 2 2 1 2 2 | 20 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 | 2 2.5|
Hyperkeratosis | 2 | 2 2.5|
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 2 | 6 2.5|
Femur, Osteopetrosis | 2 | 7 2.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 4 4 3 4 3 4 3 3 2 2 | 14 3.3|
Hemorrhage | | 1 4.0|
Hydrocephalus | 3 | 3 2.7|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hemorrhage | 3 3 | 3 2.3|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 | 14 1.1|
Inflammation, Subacute | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X | 6 3.0|
Foreign Body | | 1 2.0|
Fungus | 3 | 2 2.5|
Mucosa, Hyperplasia | | 3 1.3|
Mucosa, Metaplasia, Squamous | 2 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 7| 7| 9| 7| 8| 7| 8| 6| 6| 9| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9| |
DAY ON TEST | 5| 2| 1| 4| 1| 9| 2| 8| 9| 7| 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7| |
| 0| 2| 5| 0| 6| 6| 3| 3| 6| 7| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
UNTREATD | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | | 1 |
Mineralization | 2 3 1 2 3 1 2 2 2 1 1 2 2 1 2 1 1 2 2 2 2| 45 1.9|
Nephropathy | 1 1 3 1 2 1 1 1 1 2 1 1 1 2 1 1 1 2 2| 40 1.3|
Renal Tubule, Hyperplasia | | 1 1.0|
Renal Tubule, Pigmentation | 1 1 1 1 1 3 1 1 1 1 2 1 1 1 1 1 1 2 1 1 2 2 1 1| 48 1.4|
Transitional Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6| 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8|
DAY ON TEST | 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9| 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4|
| 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6| 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.4% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X 2 X 3 X X X X X X X|
Eosinophilic Focus | X X X X X X X X |
Granuloma | 1 1 1 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X |
Mixed Cell Focus | |
Thrombosis | 2 2 |
Bile Duct, Hyperplasia | 1 1 1 1 |
Kupffer Cell, Pigmentation | 2 2 3 2 2 1 3 4 2 1 2 1|
Lobules, Necrosis | 1 2 |
__________________________________________________________________________|
Mesentery | + +|
Accessory Spleen | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 2 1 1 1 2 1 2 2 1 1 |
Acinar Cell, Hyperplasia, Focal | 1 |
Acinus, Metaplasia, Goblet Cell | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 3 1 2 2 2 2 2 2 3 1 3 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6| 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8|
DAY ON TEST | 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9| 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4|
| 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6| 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.4% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 1 1 2 2|
Angiectasis | 1 3 1 1 1 1 1 2 1 1 3 2 2 4 2 2 2 1|
Degeneration, Fatty | 1 2 1 3 1 3 2|
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 2 |
Hyperplasia, Focal | 2 1 |
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Metaplasia, Hepatocyte | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 3 |
Pars Distalis, Cyst | 3 3 X X X X 3 3|
Pars Distalis, Hyperplasia, Focal | 3 3 3 1 2 2 1 |
Pars Intermedia, Angiectasis | 3 2 |
Pars Intermedia, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 3 1 1 |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 3 3 3 3 2 |
Hyperplasia | 4|
Inflammation, Chronic | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 |
Hyperplasia, Cystic | 2 2 1 1 |
__________________________________________________________________________|
Vagina | + M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6| 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8|
DAY ON TEST | 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9| 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4|
| 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6| 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.4% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
Hyperplasia, Reticulum Cell | 2 |
Myelofibrosis | 2 3 |
Necrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Mediastinal, Hemorrhage | 3|
Mediastinal, Pigmentation | 3 |
Pancreatic, Pigmentation | 3 |
Renal, Pigmentation | 4 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 2 |
Hemorrhage | 2 2 2 |
Hyperplasia, Lymphoid | 3 2 2 2 3 |
Pigmentation | 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2|
Hematopoietic Cell Proliferation | 1 2 2 1 |
Hemorrhage | 3 |
Pigmentation, Hemosiderin | 1 2 2 2 2 2 3 2 2 2 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + M + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 1 2 2 2 3 |
Hyperplasia | 2 1 1 1 2 2 1 1 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 3 3 3|
Cyst Epithelial Inclusion | |
Edema | 4|
Hyperkeratosis | 2 |
Inflammation, Chronic | |
Ulcer | 2 2 3 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 2 3 3 |
Femur, Osteopetrosis | 3 2 3 3 |
Rib, Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6| 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8|
DAY ON TEST | 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9| 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4|
| 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6| 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2.4% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 2 |
Hemorrhage | |
Hydrocephalus | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 3 1 1 1 1 1 1 2 1 2 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 3 3 |
Fungus | |
Mucosa, Hyperplasia | 2 |
Mucosa, Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X X X |
Inflammation, Suppurative | 1 1 |
Mineralization | 2 1 1 2 2 1 1 1 2 1 1 1 1 1 |
Nephropathy | 2 2 2 1 2 3 1 1 1 2 1 1 2 1 1 1 2 2 2 1 1 2 1 3|
Papilla, Necrosis | 2 |
Renal Tubule, Atrophy | 3 |
Renal Tubule, Dilatation | 2 3 1 2 2 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Necrosis | 1 |
Renal Tubule, Pigmentation | 3 1 2 2 1 2 2 1 2 1 1 3 3 2 3 3 2 2 2 2 2 2 2 2|
Transitional Epithelium, Hyperplasia | 2 1 2 2 2 3 1 1 1 2 2 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Transitional Epithelium, Hyperplasia | 1 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7| |
DAY ON TEST | 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7| 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4| |
| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
2.4% | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Muscularis, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 38 2.5|
Eosinophilic Focus | X X X X X | 13 |
Granuloma | 2 | 5 1.2|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X X | 10 |
Mixed Cell Focus | X | 1 |
Thrombosis | | 2 2.0|
Bile Duct, Hyperplasia | 1 1 2 1 1 2 1| 11 1.2|
Kupffer Cell, Pigmentation | 3 3 3 3 2 3 3 2 3 | 21 2.4|
Lobules, Necrosis | 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Accessory Spleen | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 2 1 1 2 1 1 1 | 22 1.3|
Acinar Cell, Hyperplasia, Focal | | 1 1.0|
Acinus, Metaplasia, Goblet Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Ulcer | 4 | 1 4.0|
Mucosa, Hyperplasia | 2 1 3 | 4 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 4 | 2 2.5|
__________________________________________________________________________|____________|
Tooth | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7| |
DAY ON TEST | 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7| 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4| |
| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
2.4% | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 1 2 3 3 2 1 1 2 2| 26 2.0|
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 1 X 1 2 2 2 2 1 2 2 | 17 1.7|
Angiectasis | 1 2 1 2 2 1 2 1 1 1 1 2 1 1 1 1 2 1 1| 37 1.5|
Degeneration, Fatty | 1 1 3 1 1 1 | 13 1.6|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hemorrhage | 2 3| 4 2.3|
Hyperplasia, Focal | 2 | 3 1.7|
Hypertrophy, Focal | 2 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 1 1 2 2 | 9 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
Metaplasia, Hepatocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 3 1 1 | 6 2.3|
Pars Distalis, Cyst | 3 3 X| 11 3.0|
Pars Distalis, Hyperplasia, Focal | 2 4 1 2 2 1 3 1 2| 16 2.1|
Pars Intermedia, Angiectasis | 2 | 3 2.3|
Pars Intermedia, Cyst | 3 X 3 3 3 | 7 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 | 6 1.5|
Follicle, Cyst | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 3 3 3 3 3 | 12 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7| |
DAY ON TEST | 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7| 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4| |
| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
2.4% | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 1 4.0|
Inflammation, Chronic | 2 | 1 2.0|
Inflammation, Suppurative | 1 | 2 1.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrometra | | 2 2.0|
Hyperplasia, Cystic | 1 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Vagina | M M M | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 2 | 1 2.0|
Hyperplasia, Reticulum Cell | | 1 2.0|
Myelofibrosis | 3 3 2 | 5 2.6|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + +| 18 |
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Pigmentation | 3 3 | 3 3.0|
Pancreatic, Pigmentation | 3 3 4| 4 3.3|
Renal, Pigmentation | 3 4| 4 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 2 | 7 2.0|
Hemorrhage | 3 2 1 2 | 7 2.0|
Hyperplasia, Lymphoid | 2 | 6 2.3|
Pigmentation | 2 2 2 2 2 2 2 2 | 17 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 3 2 3 3| 7 2.6|
Hematopoietic Cell Proliferation | 1 1 2 2| 8 1.5|
Hemorrhage | | 1 3.0|
Pigmentation, Hemosiderin | 2 2 3 2 2 2 1 1 2 2 3 3 | 24 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 3 3 2 3 2 | 12 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7| |
DAY ON TEST | 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7| 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4| |
| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
2.4% | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 1 2 2 2 1 1 1 2 2 2 2 2 2 2 1 2 2 1 1 2 1| 32 1.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 | 6 3.0|
Cyst Epithelial Inclusion | X | 1 |
Edema | 3 | 2 3.5|
Hyperkeratosis | 4 | 2 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | | 4 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | 2 3 2 3 3 | 9 2.7|
Femur, Osteopetrosis | 2 3 3 3 | 8 2.8|
Rib, Osteopetrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Compression | 2 4 3 2 | 7 2.7|
Hemorrhage | 1 2 | 2 1.5|
Hydrocephalus | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | 1 2 1 1 1 1 3 2 2 1 | 21 1.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | 3 3 3 3 | 6 3.0|
Fungus | 2 | 1 2.0|
Mucosa, Hyperplasia | 1 2 | 3 1.7|
Mucosa, Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7| |
DAY ON TEST | 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7| 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4| |
| 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
2.4% | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cataract | 3 3 | 2 3.0|
Retina, Degeneration | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | X X X X X | 9 |
Inflammation, Suppurative | | 2 1.0|
Mineralization | 1 1 1 2 1 2 2 2 1 1 1 1 2 1 1 3 1 | 31 1.4|
Nephropathy | 1 1 1 2 1 1 1 1 2 2 1 1 1 2 1 2 1 1 2 2 2 1 1 1 1| 49 1.4|
Papilla, Necrosis | 3 3 | 3 2.7|
Renal Tubule, Atrophy | 4 3 3 | 4 3.3|
Renal Tubule, Dilatation | 2 2 3 2 2 2 | 12 2.1|
Renal Tubule, Hyperplasia | 1| 1 1.0|
Renal Tubule, Necrosis | | 1 1.0|
Renal Tubule, Pigmentation | 2 2 2 2 2 2 1 3 2 2 2 2 3 2 2 3 2 1 1 3 2 2 3 3| 48 2.1|
Transitional Epithelium, Hyperplasia | 1 2 2 3 1 1 3 2 2 2 2 1 1 1 1| 29 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | X | 1 |
Transitional Epithelium, Hyperplasia | 2 1 1 4 1 4 3 2 3 | 16 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 8| 6| 7| 7| 6| 7| 7| 7| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8|
DAY ON TEST | 9| 9| 1| 6| 0| 1| 4| 1| 7| 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9|
| 3| 7| 7| 8| 1| 9| 0| 0| 7| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
UNTREATD | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X X |
Degeneration, Cystic | 2 2 |
Developmental Malformation | X X |
Eosinophilic Focus | 1 |
Granuloma | |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 3 2 3 3 1 3 4 2 2 1 2 3 3 3 3 2 |
Hepatocyte, Hyperplasia, Focal | 2 |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Pigmentation | 3 2 3 3 |
Lobules, Necrosis | 1 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 4 3 2 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 2 3 3 1 1 2 1 3 1 1 2 1 3|
Edema | |
Acinus, Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | 1 |
Mucosa, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 1 3 |
Ulcer | 2 3 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 8| 6| 7| 7| 6| 7| 7| 7| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8|
DAY ON TEST | 9| 9| 1| 6| 0| 1| 4| 1| 7| 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9|
| 3| 7| 7| 8| 1| 9| 0| 0| 7| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
UNTREATD | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 1 2 2 1 3 3 2 2 3 2 2 3 3 2|
Inflammation, Chronic | 2 |
Thrombosis | 3 4 3 X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 2 2 2 2 3 1 2|
Angiectasis | 3 2 1 1 2 2 1 1 2|
Degeneration, Fatty | 1 1 2 3 1 2 |
Hemorrhage | |
Hyperplasia, Focal | 1 1 1 1 2|
Hypertrophy, Focal | |
Thrombosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 4 2 3 |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 3 X X |
Pars Distalis, Hyperplasia, Focal | 4 4 3 |
Pars Intermedia, Cyst | 3 X 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3 3 X X 3 3 X 3 X 3 X X 3 X X X 3 3|
Hypospermia | 3 3 X X X X X 3 X 4 3 X 3 3 X X X 3 3|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 4 3 3 3 3 4 2|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 2 3 |
Inflammation, Suppurative | 3 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 8| 6| 7| 7| 6| 7| 7| 7| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8|
DAY ON TEST | 9| 9| 1| 6| 0| 1| 4| 1| 7| 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9|
| 3| 7| 7| 8| 1| 9| 0| 0| 7| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
UNTREATD | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 2 2 2 2 2 2 |
Inflammation, Suppurative | 2 1 3 1 2 1 1 1 1 3 3 1|
Epithelium, Hyperplasia | 1 2 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 3 2 1 2 2 1 |
Seminiferous Tubule, Atrophy | 4 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
Myelofibrosis | 4 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Deep Cervical, Hemorrhage | |
Inguinal, Pigmentation | |
Mediastinal, Pigmentation | 3 3 3 |
Pancreatic, Hemorrhage | |
Pancreatic, Pigmentation | 3 3 4 |
Renal, Pigmentation | 3 4 4 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Ectasia | 2 2 2 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 4 4 3 |
Pigmentation | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 4 1 3 |
Hematopoietic Cell Proliferation | 3 2 2 3 |
Metaplasia, Lipocyte | 3 |
Necrosis | |
Pigmentation, Hemosiderin | 2 2 2 2|
__________________________________________________________________________|
Thymus | + + + + M + + + + + + I + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Cyst Epithelial Inclusion | |
Hyperkeratosis | 4 |
Inflammation, Chronic | 4 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 8| 6| 7| 7| 6| 7| 7| 7| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8|
DAY ON TEST | 9| 9| 1| 6| 0| 1| 4| 1| 7| 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9|
| 3| 7| 7| 8| 1| 9| 0| 0| 7| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
UNTREATD | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hydrocephalus | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 3 |
Alveolar Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 3 X X X X 3 X |
Foreign Body | 2 2 2 3 2 |
Fungus | 3 3 3 |
Mucosa, Hyperplasia | 2 2 1 2 |
Mucosa, Metaplasia, Squamous | 2 2 2 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Hemorrhage | 3 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Cyst | X |
Mineralization | 1 1 1 1 |
Nephropathy | 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
Thrombosis | |
Renal Tubule, Atrophy | |
Renal Tubule, Dilatation | |
Renal Tubule, Necrosis | 2 3 |
Renal Tubule, Pigmentation | 1 1 3 2 1 2 2 1 1 1 1 1 1 1 1 1 2 1 1 1 2 4 1 1 1|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 8| 6| 7| 7| 6| 7| 7| 7| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8|
DAY ON TEST | 9| 9| 1| 6| 0| 1| 4| 1| 7| 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9|
| 3| 7| 7| 8| 1| 9| 0| 0| 7| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
UNTREATD | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 5| 8| 6| 8| 6| 6| 8| 5| 7| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 5| 9| 1| 9| 2| 1| 9| 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4| |
| 9| 7| 6| 7| 7| 8| 4| 6| 6| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
UNTREATD | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Edema | | 1 2.0|
Parasite Metazoan | X X| 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Edema | 3 | 3 2.7|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.0|
Basophilic Focus | 3 2 X 1 X | 7 2.0|
Degeneration, Cystic | 2 1 2 | 5 1.8|
Developmental Malformation | | 2 |
Eosinophilic Focus | X | 2 1.0|
Granuloma | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Hepatodiaphragmatic Nodule | X X | 3 |
Thrombosis | 3 X | 2 3.0|
Bile Duct, Hyperplasia | 2 3 3 3 1 3 4 3 3 2 2 3 3 3 3 3 1 3| 36 2.6|
Hepatocyte, Hyperplasia, Focal | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 | 2 3.0|
Kupffer Cell, Pigmentation | 2 | 5 2.6|
Lobules, Necrosis | 3 3 3 | 5 2.4|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 12 |
Accessory Spleen | | 1 |
Fat, Necrosis | 4 3 4 3 3 | 9 3.2|
__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 3 3 3 1 2 3 3 1 3 3 1 1 1| 30 1.9|
Edema | 2 | 1 2.0|
Acinus, Cytoplasmic Alteration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Ulcer | 2 | 2 1.5|
Mucosa, Hyperplasia | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 5| 8| 6| 8| 6| 6| 8| 5| 7| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 5| 9| 1| 9| 2| 1| 9| 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4| |
| 9| 7| 6| 7| 7| 8| 4| 6| 6| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
UNTREATD | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 2 2.5|
Erosion | 1 1 | 4 1.5|
Ulcer | 2 | 3 2.3|
__________________________________________________________________________|____________|
Tongue | | 1 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 1 3 2 2 1 3 2 2 1 3 2 1 1| 30 2.1|
Inflammation, Chronic | | 1 2.0|
Thrombosis | 3 3 | 6 3.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 2 3 1 1 1| 15 1.8|
Angiectasis | 2 3 1 2 2 3 2 1 1 1 1 1| 21 1.7|
Degeneration, Fatty | 3 3 3 3 1 3 | 12 2.2|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Focal | 1 1 | 7 1.1|
Hypertrophy, Focal | 3 1 2 3 | 4 2.3|
Thrombosis | 3 1 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 1 1 2 1 1 1 | 14 1.6|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 4 | 2 3.0|
Pars Distalis, Cyst | X 3 X 3 3 X 3 | 10 3.0|
Pars Distalis, Hyperplasia, Focal | 1 3 1 2 2 1 | 9 2.3|
Pars Intermedia, Cyst | X 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 3 1 | 8 1.4|
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 5| 8| 6| 8| 6| 6| 8| 5| 7| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 5| 9| 1| 9| 2| 1| 9| 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4| |
| 9| 7| 6| 7| 7| 8| 4| 6| 6| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
UNTREATD | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 3 2 3 3 4 3 4 X 3 X 3 3 | 30 3.1|
Hypospermia | 3 3 3 4 3 3 4 3 3 4 3 3 X 3 4 X 4 3 4 3| 39 3.3|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 3 2 2 2 2 | 14 2.8|
Inflammation, Chronic | 2 3 2 2 3 2 2| 17 2.2|
Inflammation, Suppurative | 2 3 1 1 2 2 | 12 1.9|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 2 2 3 3 2 2 3 2 3 2 2 2 1 3 | 22 2.2|
Inflammation, Suppurative | 2 1 3 1 1 1 3 2 1 1 2| 23 1.7|
Epithelium, Hyperplasia | 2 2 2 1 2 1 1 | 11 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 2 2| 9 1.9|
Seminiferous Tubule, Atrophy | 4 3 | 5 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | | 1 3.0|
Myelofibrosis | 3 | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + +| 28 |
Deep Cervical, Hemorrhage | 3| 1 3.0|
Inguinal, Pigmentation | 3 | 1 3.0|
Mediastinal, Pigmentation | 3 3 3 2 3 3 3 | 10 2.9|
Pancreatic, Hemorrhage | 4 | 1 4.0|
Pancreatic, Pigmentation | 3 3 4 3 | 7 3.3|
Renal, Pigmentation | 4 | 5 3.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 3 | 5 2.2|
Hemorrhage | 2 3 1 2 3| 6 2.0|
Hyperplasia, Lymphoid | 3 2 | 5 3.2|
Pigmentation | 2 2 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 3 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 4 2 3 3 2| 9 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 5| 8| 6| 8| 6| 6| 8| 5| 7| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 5| 9| 1| 9| 2| 1| 9| 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4| |
| 9| 7| 6| 7| 7| 8| 4| 6| 6| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
UNTREATD | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 3 4 2 2| 8 2.6|
Metaplasia, Lipocyte | | 1 3.0|
Necrosis | 4 | 1 4.0|
Pigmentation, Hemosiderin | 2 1 1 1 | 8 1.6|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + + I + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + M + + M + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia | 3 2 2 | 10 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 | 2 3.0|
Cyst Epithelial Inclusion | X X | 2 |
Hyperkeratosis | 3 4 | 3 3.7|
Inflammation, Chronic | | 1 4.0|
Ulcer | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Osteopetrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 3.0|
Hydrocephalus | 2 2| 3 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 3 1 1 1 2 2 | 9 1.7|
Alveolar Epithelium, Hyperplasia | 2 2 1 3 | 6 2.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X 3 X 3 3 3 X X | 16 3.0|
Foreign Body | 2 2 2 | 8 2.1|
Fungus | 3 3 4 2 3 4 3 3 | 11 3.1|
Mucosa, Hyperplasia | 2 2 3 2 2 2 1 | 11 1.9|
Mucosa, Metaplasia, Squamous | 3 2 2 3 3 2 | 12 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 5| 8| 6| 8| 6| 6| 8| 5| 7| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7| |
DAY ON TEST | 6| 9| 5| 9| 1| 9| 2| 1| 9| 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4| |
| 9| 7| 6| 7| 7| 8| 4| 6| 6| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
UNTREATD | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Micro Observation Only | X | 1 |
Cyst | X | 2 |
Mineralization | 1 2 | 6 1.2|
Nephropathy | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 49 1.1|
Thrombosis | 1 | 1 1.0|
Renal Tubule, Atrophy | 2 | 1 2.0|
Renal Tubule, Dilatation | 2 2 | 2 2.0|
Renal Tubule, Necrosis | 1 3 | 4 2.3|
Renal Tubule, Pigmentation | 1 1 3 1 1 1 1 1 1 2 3 2 2 2 2 1 1 2 1 2 1 1 1 2 1| 50 1.4|
Transitional Epithelium, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 5| 5| 8| 6| 6| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6|
DAY ON TEST | 9| 7| 2| 9| 6| 7| 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3|
| 7| 9| 1| 7| 9| 5| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.2% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A M + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + A + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
Edema | 2 2 2 2 2 |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + A + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Basophilic Focus | X X 3 3 2 |
Clear Cell Focus | X |
Congestion | |
Cyst | X |
Degeneration, Cystic | 3 |
Eosinophilic Focus | 2 X 3 X X 3 3 |
Granuloma | 3 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 3 3 3 3 2 3 1 3 3 2 2 3 |
Centrilobular, Necrosis | 2 |
Hepatocyte, Hyperplasia, Focal | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 |
Kupffer Cell, Pigmentation | 2 3 2 |
Lobules, Necrosis | 3 2|
__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 3 4 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +|
Atrophy | 1 3 3 2 3 3 1 2 3 2 3 1 1 1 |
Inflammation, Chronic | |
Acinus, Cytoplasmic Alteration | 1 |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +|
Edema | 3|
Erosion | 2 3 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 5| 5| 8| 6| 6| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6|
DAY ON TEST | 9| 7| 2| 9| 6| 7| 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3|
| 7| 9| 1| 7| 9| 5| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.2% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 1 1 1 3 3 2 3 3 1 3 1 3 2 1 3 3 2 1|
Thrombosis | X 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2 2 2 3 1 2 2 |
Angiectasis | 2 1 2 1 2 3 1 1 2 2 3 2 |
Cyst | X |
Degeneration, Fatty | 1 2 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Focal | 1 1 |
Hypertrophy, Focal | 2 |
Necrosis | |
Thrombosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X 3 X |
Pars Distalis, Hyperplasia, Focal | 2 1 2 |
Pars Intermedia, Angiectasis | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3 X 3 X 3 X X 3 X 3|
Hypospermia | 3 3 X 3 3 3 X 3 3 X 3 3 3 X X 3 X 3 3 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 3 3 2 2 3 2|
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 5| 5| 8| 6| 6| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6|
DAY ON TEST | 9| 7| 2| 9| 6| 7| 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3|
| 7| 9| 1| 7| 9| 5| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.2% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 2 2 3 2 2 2 2 |
Inflammation, Suppurative | 1 3 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 2 2 2 2 2 3 2 2 2 2|
Inflammation, Suppurative | 1 1 2 1 4 1|
Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | M + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 |
Seminiferous Tubule, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
Myelofibrosis | 2 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + +|
Iliac, Hemorrhage | 3|
Mediastinal, Hemorrhage | 3 |
Mediastinal, Pigmentation | 2 3 2 4 |
Pancreatic, Necrosis | |
Pancreatic, Pigmentation | 2 3 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Ectasia | 2 |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | |
Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + + + + + + + + + + + +|
Fibrosis | 3 3 3 4 2 3 2 |
Hematopoietic Cell Proliferation | 1 4 3 |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic | |
Necrosis | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + M + + + + + + +|
Ectopic Parathyroid Gland | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 5| 5| 8| 6| 6| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6|
DAY ON TEST | 9| 7| 2| 9| 6| 7| 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3|
| 7| 9| 1| 7| 9| 5| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.2% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 3 |
Cyst Epithelial Inclusion | |
Hyperkeratosis | 4 3 3 |
Inflammation, Chronic | |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + M + + + + + + + + + + + + +|
Compression | 3 |
Hydrocephalus | 2|
Necrosis | 3 |
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 |
Inflammation, Subacute | 1 |
Alveolar Epithelium, Hyperplasia | 3 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 3 3 3 |
Foreign Body | 2 |
Fungus | 3 3 3 |
Mucosa, Hyperplasia | 2 3 1 |
Mucosa, Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + A + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Mineralization | 1 1 3 1 |
Nephropathy | 2 1 1 2 1 1 1 1 2 1 2 2 2 2 2 2 2 2 1 2 1 2 3 1|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
_____________________________________________________________________________________________________________________
| 8| 5| 5| 8| 6| 6| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6|
DAY ON TEST | 9| 7| 2| 9| 6| 7| 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3|
| 7| 9| 1| 7| 9| 5| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1.2% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Thrombosis | 2 |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Necrosis | 1 |
Renal Tubule, Pigmentation | 2 2 2 2 3 2 2 2 1 2 3 3 2 2 2 2 2 2 2 2 2 2 2 2|
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 7| 4| 8| 8| 8| 6| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7| |
DAY ON TEST | 2| 9| 4| 9| 0| 4| 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7| |
| 3| 9| 4| 7| 7| 1| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
1.2% | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 3 2 | 8 2.1|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 3 2.3|
Basophilic Focus | X 2 X X 1 X X | 12 2.2|
Clear Cell Focus | X | 2 |
Congestion | 3 | 1 3.0|
Cyst | | 1 |
Degeneration, Cystic | | 1 3.0|
Eosinophilic Focus | X | 8 2.8|
Granuloma | 1 1 | 3 1.7|
Hepatodiaphragmatic Nodule | X | 2 |
Mixed Cell Focus | X | 1 |
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 3 2 2 2 3 1 3 1 1 3 2 2| 24 2.3|
Centrilobular, Necrosis | | 1 2.0|
Hepatocyte, Hyperplasia, Focal | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 | 4 3.0|
Kupffer Cell, Pigmentation | 2 3 3 2 2 | 8 2.4|
Lobules, Necrosis | 2 3 3 | 5 2.6|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 9 |
Accessory Spleen | X | 2 |
Fat, Necrosis | 2 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 1 1 1 1 1 1 1 2 1 3 1 2| 27 1.7|
Inflammation, Chronic | 4 | 1 4.0|
Acinus, Cytoplasmic Alteration | 1 1 | 3 1.0|
Acinus, Hyperplasia, Focal | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 7| 4| 8| 8| 8| 6| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7| |
DAY ON TEST | 2| 9| 4| 9| 0| 4| 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7| |
| 3| 9| 4| 7| 7| 1| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
1.2% | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | | 1 3.0|
Erosion | 2 2 3 2 | 6 2.3|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 1 1 1 2 1 3 2 2 3 1 2 2| 32 2.0|
Thrombosis | 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 1 3 2 1 2 1 2 2 3 | 18 1.9|
Angiectasis | 2 2 2 2 1 1 2 3 1 1 3 3 | 24 1.9|
Cyst | | 1 |
Degeneration, Fatty | 2 | 4 1.5|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Focal | 1 2 | 4 1.3|
Hypertrophy, Focal | 2 2 | 3 2.0|
Necrosis | 2 | 1 2.0|
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 4 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | 3 X X | 7 3.0|
Pars Distalis, Hyperplasia, Focal | 2 3 3 3 2 4 2 | 10 2.4|
Pars Intermedia, Angiectasis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 | 4 1.8|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 7| 4| 8| 8| 8| 6| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7| |
DAY ON TEST | 2| 9| 4| 9| 0| 4| 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7| |
| 3| 9| 4| 7| 7| 1| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
1.2% | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | X 3 3 3 3 3 X 3 3 X X 3 3 | 23 3.0|
Hypospermia | X 3 3 3 3 3 3 3 X 3 X 3 3 3 X X 3 3 3 X| 40 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 | 9 2.4|
Hyperplasia | | 1 3.0|
Inflammation, Chronic | 2 2 2 2 2 2 | 13 2.1|
Inflammation, Suppurative | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 2 3 2 3 3 2 2 2 2 | 21 2.2|
Inflammation, Suppurative | 1 2 2 3 2 1 3 1 3 | 15 1.9|
Epithelium, Hyperplasia | 2 1 | 4 1.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 1 3 | 5 1.8|
Seminiferous Tubule, Atrophy | 4 3 | 4 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 3 | 2 2.5|
Myelofibrosis | 3 2 | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + +| 23 |
Iliac, Hemorrhage | | 1 3.0|
Mediastinal, Hemorrhage | 3 | 2 3.0|
Mediastinal, Pigmentation | 4 4 | 6 3.2|
Pancreatic, Necrosis | 4 | 1 4.0|
Pancreatic, Pigmentation | 3 3 3 | 5 2.8|
Renal, Pigmentation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 2 | 2 2.0|
Hemorrhage | 1 3 2 | 5 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Pigmentation | 2 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 7| 4| 8| 8| 8| 6| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7| |
DAY ON TEST | 2| 9| 4| 9| 0| 4| 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7| |
| 3| 9| 4| 7| 7| 1| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
1.2% | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 2 3 2 2 2 2 3 3 | 15 2.6|
Hematopoietic Cell Proliferation | 2 | 4 2.5|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Necrosis | 3 | 1 3.0|
Pigmentation, Hemosiderin | 2 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + M + + + M + + + + + +| 45 |
Ectopic Parathyroid Gland | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 3 2 2| 8 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + I + + + M + + + + + + +| 48 |
Acanthosis | 3 3 2 2 | 7 2.7|
Cyst Epithelial Inclusion | X | 1 |
Hyperkeratosis | 3 3 2 3 | 7 3.0|
Inflammation, Chronic | 2 2 2 | 3 2.0|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Osteopetrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | 3 | 2 3.0|
Hydrocephalus | 2 | 2 2.0|
Necrosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Edema | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 2 2 1 1 1 | 12 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05094-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/04/95
Route: DOSED FEED Time: 22:08:25
__________________________________________________________________________________________________________________________________
| 7| 4| 8| 8| 8| 6| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7| |
DAY ON TEST | 2| 9| 4| 9| 0| 4| 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7| |
| 3| 9| 4| 7| 7| 1| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
1.2% | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Subacute | 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | 3 X 3 3 | 7 3.0|
Foreign Body | | 1 2.0|
Fungus | 2 2 | 5 2.6|
Mucosa, Hyperplasia | 2 1 1 | 6 1.7|
Mucosa, Metaplasia, Squamous | 2 1 2 | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | | 1 2.0|
Mineralization | 1 | 5 1.4|
Nephropathy | 1 1 1 2 1 1 2 1 2 2 1 2 1 1 1 2 1 3 1 1 1 1 2 1| 48 1.5|
Thrombosis | 1 | 2 1.5|
Renal Tubule, Dilatation | 2 2 | 3 2.3|
Renal Tubule, Necrosis | 3 3 3 | 4 2.5|
Renal Tubule, Pigmentation | 2 2 2 2 3 2 1 2 2 3 4 2 2 1 3 2 2 2 2 1 4 2 2| 47 2.1|
Transitional Epithelium, Hyperplasia | 1| 1 1.0|
__________________________________________________________________________|____________|
Urethra | +| 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
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