TDMS Study 05094-99 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
BUTYL BENZYL PHTHALATE
NTP Experiment-Test: 05094-99 Report: PEIRPT05
Study Type: CHRONIC Date: 05/11/95
Route: DOSED FEED Time: 10:20:09
05094/02 -VS- 05094/03 COMPARISON
Facility: SOUTHERN RESEARCH INSTITUTE
Chemical CAS #: 85-68-7
Lock Date: 11/25/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25004 Dead
25005 Interval Sacrifice 25003 Moribund
25019 Moribund Sacrifice 25020 Natural Death
25026 Other 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 AD LIB CONTROL
Include 002 AD LIB CONTROL
Include 005 RTD CONTROL
Include 006 RTD CONTROL
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/11/95
Route: DOSED FEED Time: 10:20:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 110
Scheduled Sacrifice 35
Early Deaths
Moribund Sacrifice 23 2
Natural Death 2
Dead 4
Moribund 11
Survivors
Terminal Sacrifice 25
Animals Examined Microscopically 50 52
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (52)
Intestine Small, Jejunum (50) (52)
Leiomyosarcoma 1 (2%)
Liver (50) (52)
Hepatocellular Adenoma 1 (2%)
Mesentery (10) (1)
Liposarcoma 1 (10%)
Pancreas (50) (49)
Salivary Glands (49) (51)
Stomach, Forestomach (50) (51)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (52)
Tongue (3)
Squamous Cell Papilloma 2 (67%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (52)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (52)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Adrenal Medulla (49) (51)
Pheochromocytoma Malignant 1 (2%)
Page 2
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/11/95
Route: DOSED FEED Time: 10:20:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 1 (2%) 1 (2%)
Islets, Pancreatic (50) (49)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (49) (52)
Pars Distalis, Adenoma 19 (39%) 17 (33%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Pars Distalis, Carcinoma 2 (4%)
Thyroid Gland (49) (51)
C-Cell, Adenoma 4 (8%) 2 (4%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (52)
Adenoma 3 (6%) 3 (6%)
Carcinoma 4 (8%)
Ovary (50) (52)
Granulosa Cell Tumor Benign 2 (4%) 1 (2%)
Uterus (50) (52)
Adenoma 1 (2%)
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 6 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (52)
Lymph Node (12) (10)
Lymph Node, Mandibular (49) (51)
Lymph Node, Mesenteric (50) (52)
Spleen (50) (52)
Thymus (49) (52)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/11/95
Route: DOSED FEED Time: 10:20:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (52)
Adenoma 2 (4%)
Carcinoma 2 (4%) 1 (2%)
Fibroadenoma 28 (57%) 10 (19%)
Fibroadenoma, Multiple 2 (4%)
Skin (50) (52)
Keratoacanthoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (52)
Astrocytoma Malignant 1 (2%)
Carcinoma 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 2 (4%)
Oligodendroglioma Malignant 1 (2%)
Spinal Cord (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (52)
Alveolar/Bronchiolar Adenoma 2 (4%) 1 (2%)
Sarcoma, Metastatic, Tissue NOS 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (52)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (52)
Mast Cell Tumor Benign 1 (2%)
Page 4
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/11/95
Route: DOSED FEED Time: 10:20:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(52)
Leukemia Mononuclear 21 (42%) 17 (33%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/11/95
Route: DOSED FEED Time: 10:20:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 44
Total Primary Neoplasms 112 72
Total Animals with Benign Neoplasms 40 31
Total Benign Neoplasms 77 45
Total Animals with Malignant Neoplasms 30 25
Total Malignant Neoplasms 35 27
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 2 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/11/95
Route: DOSED FEED Time: 10:20:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 110
Scheduled Sacrifice 34
Early Deaths
Moribund Sacrifice 19
Natural Death 3
Moribund 14
Dead 1
Survivors
Terminal Sacrifice 28
Accidently Killed 1
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (49) (50)
Leiomyosarcoma 1 (2%)
Intestine Small, Duodenum (50) (50)
Intestine Small, Jejunum (49) (49)
Leiomyoma 1 (2%)
Intestine Small, Ileum (49) (49)
Liver (50) (50)
Hepatocellular Adenoma 2 (4%) 1 (2%)
Mesentery (7) (7)
Sarcoma 1 (14%)
Oral Mucosa (1)
Squamous Cell Carcinoma 1 (100%)
Pancreas (50) (50)
Sarcoma, Metastatic, Mesentery 1 (2%)
Acinus, Adenoma 3 (6%)
Stomach, Forestomach (50) (50)
Leiomyosarcoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (50)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/11/95
Route: DOSED FEED Time: 10:20:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50)
Adrenal Medulla (50) (50)
Pheochromocytoma Malignant 2 (4%) 1 (2%)
Pheochromocytoma Benign 6 (12%) 3 (6%)
Pheochromocytoma Benign, Multiple 3 (6%)
Islets, Pancreatic (50) (50)
Adenoma 5 (10%) 4 (8%)
Carcinoma 1 (2%)
Pituitary Gland (50) (46)
Pars Distalis, Adenoma 9 (18%) 4 (9%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Thyroid Gland (50) (50)
C-Cell, Adenoma 5 (10%) 4 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50)
Preputial Gland (50) (50)
Adenoma 4 (8%) 1 (2%)
Carcinoma 1 (2%)
Prostate (50) (49)
Seminal Vesicle (50) (50)
Testes (50) (50)
Bilateral, Interstitial Cell, Adenoma 37 (74%) 42 (84%)
Interstitial Cell, Adenoma 7 (14%) 5 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Lymph Node (23) (12)
Iliac, Leiomyosarcoma, Metastatic, Intestine
Large, Rectum 1 (4%)
Lymph Node, Mandibular (49) (48)
Lymph Node, Mesenteric (50) (50)
Page 8
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/11/95
Route: DOSED FEED Time: 10:20:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Spleen (50) (50)
Thymus (49) (46)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (49)
Fibroadenoma 2 (4%) 2 (4%)
Skin (50) (49)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 2 (4%) 2 (4%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 5 (10%)
Subcutaneous Tissue, Melanoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Chordoma 1 (2%)
Skeletal Muscle (1)
Hemangiosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Oligodendroglioma Malignant 1 (2%)
Spinal Cord (2) (1)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50)
Chordoma, Metastatic, Bone 1 (2%)
Sarcoma, Metastatic, Mesentery 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/11/95
Route: DOSED FEED Time: 10:20:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Leukemia Mononuclear 31 (62%) 21 (42%)
Mesothelioma Malignant 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/11/95
Route: DOSED FEED Time: 10:20:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 49
Total Primary Neoplasms 135 100
Total Animals with Benign Neoplasms 46 48
Total Benign Neoplasms 94 69
Total Animals with Malignant Neoplasms 37 29
Total Malignant Neoplasms 41 31
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 2 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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