TDMS Study 05094-02 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL BUTYL BENZYL PHTHALATE NTP Experiment-Test: 05094-02 Report: PEIRPT09 Study Type: CHRONIC Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 RTD FEED CORE STUDY COMPARISON (REV. 1) Facility: Southern Research Institute Chemical CAS #: 85-68-7 Lock Date: 11/25/92 Cage Range: All Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death 25026 Other 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 007 1.2% Include 008 2.4% Include 009 CONTROL FEED RTD Include 010 CONTROL FEED RTD Page 1 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 4| 4| 5| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| DAY ON TEST | 1| 3| 3| 3| 8| 5| 5| 3| 2| 2| 3| 3| 0| 5| 3| 0| 3| 3| 3| 3| 3| 5| 3| 0| 8| | 1| 8| 7| 8| 7| 2| 1| 8| 2| 5| 7| 8| 7| 2| 8| 4| 7| 8| 8| 7| 8| 2| 8| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 2.4% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +| Edema | | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X | Cyst | X | Eosinophilic Focus | X X X X X X X X X| Granuloma | | Hematopoietic Cell Proliferation | 2 | Hepatodiaphragmatic Nodule | X X X X X X| Mixed Cell Focus | X X X | Bile Duct, Hyperplasia | 1 1 1 2 1 | Kupffer Cell, Pigmentation | 2 2 1 1 2 | Lobules, Necrosis | 1 1 1| __________________________________________________________________________| Mesentery | + + + + + | Accessory Spleen | X | Fat, Necrosis | 3 3 3 2 2 | __________________________________________________________________________| Oral Mucosa | | Hyperplasia | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 1 2 1 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 2 | Mucosa, Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 1 1 1 | Mineralization | | Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 4| 4| 5| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| DAY ON TEST | 1| 3| 3| 3| 8| 5| 5| 3| 2| 2| 3| 3| 0| 5| 3| 0| 3| 3| 3| 3| 3| 5| 3| 0| 8| | 1| 8| 7| 8| 7| 2| 1| 8| 2| 5| 7| 8| 7| 2| 8| 4| 7| 8| 8| 7| 8| 2| 8| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 2.4% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 1 2 | Angiectasis | 1 1 3 1 2 3 3 2 2 1 1 3 | Cyst | X| Degeneration, Fatty | 1 | Hemorrhage | 2 | Hyperplasia, Focal | 1 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Hepatocyte | 1 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 4 3 2 | Pars Distalis, Cyst | X X X X X X X X X X X | Pars Distalis, Hyperplasia, Focal | 1 3 3 1 | Pars Distalis, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 2 3 2 3 | Hyperplasia | | Inflammation, Chronic | 3 | Inflammation, Suppurative | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 2 2 2| Hyperplasia, Cystic | 1 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypercellularity | 2 | Myelofibrosis | 2 | __________________________________________________________________________| Lymph Node | + + + + + + + | Mediastinal, Hemorrhage | 2 | Mediastinal, Pigmentation | 2 3 4 | Pancreatic, Pigmentation | 2 | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 4| 4| 5| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| DAY ON TEST | 1| 3| 3| 3| 8| 5| 5| 3| 2| 2| 3| 3| 0| 5| 3| 0| 3| 3| 3| 3| 3| 5| 3| 0| 8| | 1| 8| 7| 8| 7| 2| 1| 8| 2| 5| 7| 8| 7| 2| 8| 4| 7| 8| 8| 7| 8| 2| 8| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 2.4% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Pigmentation | 4 4 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | | Pigmentation | 2 2 2 2 2 2 2| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Developmental Malformation | X | Fibrosis | 2 | Hematopoietic Cell Proliferation | 1 2 2 2 1 1 2 4 2| Pigmentation, Hemosiderin | 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Thymus | + + + + + I + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 2 3 2 2 2| Hyperplasia | 2 1 1 1 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Ulcer | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Osteopetrosis | 2 2 3 2 2 | Femur, Osteopetrosis | 1 | Rib, Osteopetrosis | 3 | __________________________________________________________________________| Skeletal Muscle | | Hemorrhage | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 3 4 4 2 | Hydrocephalus | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Hemorrhage | 2 | Infiltration Cellular, Histiocyte | 1 2 3 1 2 1 1 1 1 1 1| Inflammation, Subacute | 2 | Alveolar Epithelium, Hyperplasia | 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 4| 4| 5| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| DAY ON TEST | 1| 3| 3| 3| 8| 5| 5| 3| 2| 2| 3| 3| 0| 5| 3| 0| 3| 3| 3| 3| 3| 5| 3| 0| 8| | 1| 8| 7| 8| 7| 2| 1| 8| 2| 5| 7| 8| 7| 2| 8| 4| 7| 8| 8| 7| 8| 2| 8| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 2.4% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Exudate | X X X| Mucosa, Hyperplasia | | Mucosa, Metaplasia, Squamous | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 3 3 | Hemorrhage | | Retina, Degeneration | 2 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Micro Observation Only | | Cyst | X | Hydronephrosis | 2 | Mineralization | 2 2 1 2 2 2 1 1 2 1 2 2 1 1 1 | Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1| Renal Tubule, Atrophy | 3 | Renal Tubule, Dilatation | 3 | Renal Tubule, Necrosis | 1 | Renal Tubule, Pigmentation | 2 1 2 2 1 2 3 1 2 1 2 4 1 1 1 2 1 1 1 1 2 1 1 2| Transitional Epithelium, Hyperplasia | 1 1 | __________________________________________________________________________| Ureter | + | Dilatation | 3 | Transitional Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Hyperplasia | 3 2 3 | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 1| 3| 8| 3| 3| 3| 9| 3| 3| 3| 0| 3| 0| 3| 3| 0| 8| 3| 8| 3| 3| | | 7| 7| 8| 8| 7| 7| 1| 8| 7| 8| 2| 7| 8| 8| 7| 7| 3| 8| 8| 3| 4| 7| 4| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2.4% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Edema | 2 | 1 2.0| Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 39 | Clear Cell Focus | X X X X X | 9 | Cyst | X | 2 | Eosinophilic Focus | X X X X X X X X X X X | 20 | Granuloma | 3 2 | 2 2.5| Hematopoietic Cell Proliferation | | 1 2.0| Hepatodiaphragmatic Nodule | X X X X X X | 12 | Mixed Cell Focus | X X X | 6 | Bile Duct, Hyperplasia | 2 2 2 1| 9 1.4| Kupffer Cell, Pigmentation | 2 1 2 2 3 | 10 1.8| Lobules, Necrosis | 2 1 1 | 6 1.2| __________________________________________________________________________|____________| Mesentery | + | 6 | Accessory Spleen | | 1 | Fat, Necrosis | 2 | 6 2.5| __________________________________________________________________________|____________| Oral Mucosa | + | 1 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 2 1 2 1 2 | 12 1.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 2.0| Mucosa, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 1| 3| 8| 3| 3| 3| 9| 3| 3| 3| 0| 3| 0| 3| 3| 0| 8| 3| 8| 3| 3| | | 7| 7| 8| 8| 7| 7| 1| 8| 7| 8| 2| 7| 8| 8| 7| 7| 3| 8| 8| 3| 4| 7| 4| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2.4% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Cardiomyopathy | 1 1 1 2 2 3 1 1 | 13 1.3| Mineralization | 1 | 1 1.0| Thrombosis | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 2 2 1 | 6 1.7| Angiectasis | 2 2 3 1 1 3 3 2 2 2 2 2 3 2 3 2 2 | 29 2.1| Cyst | | 1 | Degeneration, Fatty | 1 3 1 | 4 1.5| Hemorrhage | | 1 2.0| Hyperplasia, Focal | | 2 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Hepatocyte | | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 4 2 2 3 | 7 2.9| Pars Distalis, Cyst | X X X X X X X X| 19 | Pars Distalis, Hyperplasia, Focal | 1 3 3 2 2 1 2| 11 2.0| Pars Distalis, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 | 3 1.0| Follicular Cell, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 2 3 2 4 | 10 2.6| Hyperplasia | 2 | 1 2.0| Inflammation, Chronic | | 1 3.0| Inflammation, Suppurative | 1 2 | 3 1.7| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X X | 5 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | | 3 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 1| 3| 8| 3| 3| 3| 9| 3| 3| 3| 0| 3| 0| 3| 3| 0| 8| 3| 8| 3| 3| | | 7| 7| 8| 8| 7| 7| 1| 8| 7| 8| 2| 7| 8| 8| 7| 7| 3| 8| 8| 3| 4| 7| 4| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2.4% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Hyperplasia, Cystic | 2 1 2 1 2 2 1| 11 1.6| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypercellularity | | 1 2.0| Myelofibrosis | 2 3 1 3 2 | 6 2.2| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + | 15 | Mediastinal, Hemorrhage | | 1 2.0| Mediastinal, Pigmentation | 3 4 3 3 2 3 | 9 3.0| Pancreatic, Pigmentation | 3 3 | 3 2.7| Renal, Pigmentation | 3 4 | 4 3.8| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 2 2| 3 2.0| Hemorrhage | 3 2 1 1 1 | 5 1.6| Pigmentation | 2 2 2 2 2 2 2 2 2 | 16 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 | 2 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Developmental Malformation | | 1 | Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | 1 1 1 1 2 | 14 1.6| Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 1 3 3 2 | 29 2.1| __________________________________________________________________________|____________| Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 | Hemorrhage | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 1 1 2 2| 11 1.9| Hyperplasia | 1 2 1 2 1 1 1 1 1 2 1 2 | 17 1.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 | 1 3.0| Ulcer | 3 | 2 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Osteopetrosis | 2 | 6 2.2| Femur, Osteopetrosis | 2 2 | 3 1.7| Rib, Osteopetrosis | | 1 3.0| __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 1| 3| 8| 3| 3| 3| 9| 3| 3| 3| 0| 3| 0| 3| 3| 0| 8| 3| 8| 3| 3| | | 7| 7| 8| 8| 7| 7| 1| 8| 7| 8| 2| 7| 8| 8| 7| 7| 3| 8| 8| 3| 4| 7| 4| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2.4% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | 2 3 2 3 | 8 2.9| Hydrocephalus | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Hemorrhage | | 1 2.0| Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | 19 1.2| Inflammation, Subacute | | 1 2.0| Alveolar Epithelium, Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Exudate | X | 4 | Mucosa, Hyperplasia | 2 | 1 2.0| Mucosa, Metaplasia, Squamous | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 3 | Cataract | | 2 3.0| Hemorrhage | 4 | 1 4.0| Retina, Degeneration | | 2 2.5| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Calculus Micro Observation Only | X | 1 | Cyst | X | 2 | Hydronephrosis | | 1 2.0| Mineralization | 1 2 2 1 1 1 1 1 1 2 1 1 1 2 1 1 2 1 2 2| 35 1.4| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0| Renal Tubule, Atrophy | 2 | 2 2.5| Renal Tubule, Dilatation | | 1 3.0| Renal Tubule, Necrosis | | 1 1.0| Renal Tubule, Pigmentation | 1 2 3 1 3 1 2 1 2 1 1 2 1 1 4 1 2 1 1 3 2 2 1 | 47 1.6| Transitional Epithelium, Hyperplasia | 1 1 | 4 1.0| __________________________________________________________________________|____________| Ureter | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 1| 3| 8| 3| 3| 3| 9| 3| 3| 3| 0| 3| 0| 3| 3| 0| 8| 3| 8| 3| 3| | | 7| 7| 8| 8| 7| 7| 1| 8| 7| 8| 2| 7| 8| 8| 7| 7| 3| 8| 8| 3| 4| 7| 4| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 2.4% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Dilatation | | 1 3.0| Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Hyperplasia | 2 2 2 2 1 3 2| 10 2.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 2| 3| 2| 3| 9| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 8| 7| 8| 1| 3| 8| 2| 7| 2| 8| 1| 8| 8| 1| 7| 8| 8| 8| 7| 7| 8| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| CONTROL | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X | Eosinophilic Focus | X X X X X X X X X| Granuloma | 2 1 | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X X X | Inflammation, Subacute | | Mixed Cell Focus | X X | Bile Duct, Hyperplasia | 1 2 3 | Centrilobular, Necrosis | 2 | Hepatocyte, Vacuolization Cytoplasmic| 3 | Kupffer Cell, Pigmentation | 3 3 2 2 | Lobules, Necrosis | | __________________________________________________________________________| Mesentery | + | Fat, Necrosis | 3 | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +| Atrophy | 1 1 1 1 1 1 1 1 | Cyst | | Acinus, Cytoplasmic Alteration | 1| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 1 1 2 1 1 2 2 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 2| 3| 2| 3| 9| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 8| 7| 8| 1| 3| 8| 2| 7| 2| 8| 1| 8| 8| 1| 7| 8| 8| 8| 7| 7| 8| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| CONTROL | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 2 2 1| Angiectasis | 1 1 1 2 1 1 1 | Degeneration, Fatty | | Hyperplasia, Focal | 2 2 2 | Hypertrophy, Focal | | Metaplasia, Osseous | 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + M + + + + M + + + +| Pars Distalis, Angiectasis | 3 2 3 2 | Pars Distalis, Cyst | X X X | Pars Distalis, Hyperplasia, Focal | 1 1 1 2 2 2 3 3| Pars Intermedia, Cyst | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 3 3 | Hyperplasia | | Inflammation, Chronic | 2 3 | Inflammation, Suppurative | 3 2 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrometra | 2 2 | Hyperplasia, Cystic | 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypercellularity | | Myelofibrosis | 3 | __________________________________________________________________________| Lymph Node | + + + + + + + + +| Mediastinal, Hemorrhage | 2 3| Mediastinal, Pigmentation | 3 3 3 2| Renal, Hemorrhage | | Renal, Pigmentation | 3 3 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 2| 3| 2| 3| 9| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 8| 7| 8| 1| 3| 8| 2| 7| 2| 8| 1| 8| 8| 1| 7| 8| 8| 8| 7| 7| 8| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| CONTROL | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hemorrhage | 2 1 1 2 | Hyperplasia, Lymphoid | 2 | Pigmentation | 3 2 2 2 2 2 2 2 2 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1| Hyperplasia, Lymphoid | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 4 3 | Hematopoietic Cell Proliferation | 1 | Hemorrhage | 2 | Pigmentation, Hemosiderin | 1 1 2 1 2 1 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 3 | Hyperplasia | 1 1 1 1 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Hyperkeratosis | 2 2 | Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Osteopetrosis | 2 3 | Femur, Osteopetrosis | 3 3 | Rib, Osteopetrosis | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | | Hemorrhage | | Hydrocephalus | | Necrosis | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Hemorrhage | 2 | Infiltration Cellular, Histiocyte | 1 1 1 1 3 1 1 1 | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Exudate | X X | Foreign Body | 2 | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 2| 3| 2| 3| 9| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 8| 7| 8| 1| 3| 8| 2| 7| 2| 8| 1| 8| 8| 1| 7| 8| 8| 8| 7| 7| 8| 7| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| CONTROL | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Fungus | 2 3 | Mucosa, Hyperplasia | 2 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 3 | Retina, Degeneration | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hydronephrosis | 2 2 | Mineralization | 2 2 2 2 2 2 2 3 2 2 2 3 2 3 3 3 3 2 2 1 2 2 2 2| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1| Renal Tubule, Pigmentation | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Transitional Epithelium, Hyperplasia | 1 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| | | 8| 7| 8| 8| 7| 8| 8| 8| 8| 7| 8| 8| 8| 1| 6| 7| 5| 8| 8| 8| 7| 8| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L | FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 40 | Clear Cell Focus | X | 2 | Eosinophilic Focus | X X X X X X X | 16 | Granuloma | 2 1 | 4 1.5| Hematopoietic Cell Proliferation | 2 2 | 2 2.0| Hepatodiaphragmatic Nodule | X | 4 | Inflammation, Subacute | 2 | 1 2.0| Mixed Cell Focus | X X | 4 | Bile Duct, Hyperplasia | 1 2 1 3 1 2 2 | 10 1.8| Centrilobular, Necrosis | 2 | 2 2.0| Hepatocyte, Vacuolization Cytoplasmic| | 1 3.0| Kupffer Cell, Pigmentation | | 4 2.5| Lobules, Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Mesentery | + | 2 | Fat, Necrosis | 3 | 2 3.0| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 1 1 1 3 1 2 1 1 1| 17 1.2| Cyst | X | 1 | Acinus, Cytoplasmic Alteration | 1 | 2 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tongue | + | 1 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| | | 8| 7| 8| 8| 7| 8| 8| 8| 8| 7| 8| 8| 8| 1| 6| 7| 5| 8| 8| 8| 7| 8| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L | FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 1 2 2 1 | 14 1.6| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 2 | 6 1.7| Angiectasis | 2 1 2 1 2 1 1 1 | 15 1.3| Degeneration, Fatty | 2 2 1 1 | 4 1.5| Hyperplasia, Focal | 1 1 3 2 1 2 | 9 1.8| Hypertrophy, Focal | 1 3 1 | 3 1.7| Metaplasia, Osseous | | 1 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 | 3 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + + M + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 | Pars Distalis, Angiectasis | 2 3 4 | 7 2.7| Pars Distalis, Cyst | X X X X X | 8 | Pars Distalis, Hyperplasia, Focal | 3 2 3 2 3 | 13 2.2| Pars Intermedia, Cyst | X| 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 | 4 1.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 3 | 4 3.0| Hyperplasia | 2 | 1 2.0| Inflammation, Chronic | 2 | 3 2.3| Inflammation, Suppurative | 1 | 4 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrometra | 2 2 | 4 2.0| Hyperplasia, Cystic | 2 1 | 4 1.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| | | 8| 7| 8| 8| 7| 8| 8| 8| 8| 7| 8| 8| 8| 1| 6| 7| 5| 8| 8| 8| 7| 8| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L | FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypercellularity | 3 3 | 2 3.0| Myelofibrosis | 2 | 2 2.5| __________________________________________________________________________|____________| Lymph Node | + + + +| 13 | Mediastinal, Hemorrhage | 3 | 3 2.7| Mediastinal, Pigmentation | 3 3 | 6 2.8| Renal, Hemorrhage | 2| 1 2.0| Renal, Pigmentation | 3| 4 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 2 2.0| Hemorrhage | 2 1 2 1 | 8 1.5| Hyperplasia, Lymphoid | 2 2 | 3 2.0| Pigmentation | 2 2 2 2 2 2 2 2 2 | 19 2.1| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 | 2 1.0| Hyperplasia, Lymphoid | 3 3 | 2 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | | 3 3.3| Hematopoietic Cell Proliferation | 2 4 4 | 4 2.8| Hemorrhage | | 1 2.0| Pigmentation, Hemosiderin | 1 2 1 2 2 1 1 | 13 1.4| __________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | Ectasia | 1 2 2 | 5 2.2| Hyperplasia | 2 1 1 1 | 9 1.2| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 1 | Hyperkeratosis | 2 2 | 4 2.0| Ulcer | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Osteopetrosis | 2 | 3 2.3| Femur, Osteopetrosis | 3 2 | 4 2.8| Rib, Osteopetrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| | | 8| 7| 8| 8| 7| 8| 8| 8| 8| 7| 8| 8| 8| 1| 6| 7| 5| 8| 8| 8| 7| 8| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L | FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | 3 | 1 3.0| Hemorrhage | 1 | 1 1.0| Hydrocephalus | 3 | 1 3.0| Necrosis | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 1 2.0| Hemorrhage | | 1 2.0| Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 2 | 17 1.2| Alveolar Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Exudate | X | 3 | Foreign Body | | 1 2.0| Fungus | | 2 2.5| Mucosa, Hyperplasia | | 3 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | +| 2 | Cataract | 3| 2 3.0| Retina, Degeneration | 4| 2 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Hydronephrosis | | 2 2.0| Mineralization | 3 3 3 2 2 3 2 2 2 2 3 2 2 2 2 3 3 1 1 1 2 2 3 2 2| 49 2.2| Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 32 1.0| Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 48 1.0| Transitional Epithelium, Hyperplasia | 1 1 | 4 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 2| 4| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| DAY ON TEST | 9| 3| 3| 3| 3| 9| 6| 6| 7| 8| 0| 3| 5| 9| 3| 3| 3| 3| 3| 3| 6| 6| 3| 7| 1| | 8| 1| 0| 4| 9| 7| 4| 2| 4| 4| 3| 1| 4| 8| 0| 1| 1| 0| 1| 0| 6| 8| 1| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1.2% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | Ulcer | 4 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Basophilic Focus | X X X X X X X | Clear Cell Focus | X X X | Cyst | X | Degeneration, Cystic | 2 1 2 2 | Eosinophilic Focus | X | Granuloma | 1 3 1 | Hemorrhage | 3 | Hepatodiaphragmatic Nodule | X X X X X | Inflammation, Subacute | 1 1 2 | Mixed Cell Focus | X X X X | Bile Duct, Hyperplasia | 1 1 3 3 3 3 2 2 1 3 2 4 3 2 | Centrilobular, Necrosis | 2 | Hepatocyte, Vacuolization Cytoplasmic| 3 3 4 | Kupffer Cell, Pigmentation | 2 2 2 2| Lobules, Necrosis | 1 | __________________________________________________________________________| Mesentery | + + + +| Accessory Spleen | | Fat, Necrosis | 3 4 3| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 3 1 3 3 1 1 1 1 1 3 1| Acinus, Hyperplasia, Focal | 3 2 3 2 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 3 4 3 | Ulcer | 4 3 | Mucosa, Hyperplasia | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Ulcer | 3 | __________________________________________________________________________| Tongue | | Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 2| 4| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| DAY ON TEST | 9| 3| 3| 3| 3| 9| 6| 6| 7| 8| 0| 3| 5| 9| 3| 3| 3| 3| 3| 3| 6| 6| 3| 7| 1| | 8| 1| 0| 4| 9| 7| 4| 2| 4| 4| 3| 1| 4| 8| 0| 1| 1| 0| 1| 0| 6| 8| 1| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1.2% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 2 3 2 1 3 2 3 1 2 3 2 1 1 2| Thrombosis | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 1 | Angiectasis | 3 3 | Degeneration, Fatty | 2 2 1 3 | Hemorrhage | 2 | Hyperplasia, Focal | 1 | Hypertrophy, Focal | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 2 2 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia, Focal | 1 3 | Pars Distalis, Hyperplasia | 2 | Pars Distalis, Necrosis | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ultimobranchial Cyst | X X | C-Cell, Hyperplasia | 1 2 1 1| Follicle, Cyst | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Atypia Cellular | 3 3 3 3 X 3 3 3 3 3 3 3 3 3 3 3 3 | Hypospermia | 3 3 3 3 3 X 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 2 2 2 3 2 3 2 | Hyperplasia | 2 | Inflammation, Chronic | 2 2 2 2 3 2 2 2| Inflammation, Suppurative | 2 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 2| 4| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| DAY ON TEST | 9| 3| 3| 3| 3| 9| 6| 6| 7| 8| 0| 3| 5| 9| 3| 3| 3| 3| 3| 3| 6| 6| 3| 7| 1| | 8| 1| 0| 4| 9| 7| 4| 2| 4| 4| 3| 1| 4| 8| 0| 1| 1| 0| 1| 0| 6| 8| 1| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1.2% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Corpora Amylacea | 2 2 2 2 1 2 2 2 3 3 2 | Fibrosis | 3| Inflammation, Suppurative | 3 1 2 2 2 1 2 3| Epithelium, Hyperplasia | 2 2 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 1 1 | Seminiferous Tubule, Atrophy | 4 4 3| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + + | Mediastinal, Pigmentation | 3 4 | Pancreatic, Hemorrhage | 3 | Pancreatic, Pigmentation | 3 | Renal, Pigmentation | 3 4 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 2 3| Hemorrhage | 1 2 1 2 | Hyperplasia, Lymphoid | 2 2 2 2 2| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2| Hemorrhage | 2 2 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 3 3 4 3 2 3 | Granuloma | | Hematopoietic Cell Proliferation | 1 1 | Pigmentation, Hemosiderin | 2 2 1 2| __________________________________________________________________________| Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + M + + + + M + + + + + + + + + + +| Hyperplasia | 2 1 3 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 2 3 | Cyst Epithelial Inclusion | X | Hemorrhage | 2 | Hyperkeratosis | 4 2 3 3 3 | Inflammation, Chronic | 2 | Ulcer | 4 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 6| 7| 7| 6| 6| 2| 4| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| DAY ON TEST | 9| 3| 3| 3| 3| 9| 6| 6| 7| 8| 0| 3| 5| 9| 3| 3| 3| 3| 3| 3| 6| 6| 3| 7| 1| | 8| 1| 0| 4| 9| 7| 4| 2| 4| 4| 3| 1| 4| 8| 0| 1| 1| 0| 1| 0| 6| 8| 1| 4| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1.2% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Hyperostosis | 3 | Femur, Osteopetrosis | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | 4| Gliosis | | Hemorrhage | 2 | Hydrocephalus | 2| Mineralization | | Necrosis | 3 | Cerebellum, Necrosis | 3 | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage | | Infiltration Cellular, Histiocyte | 1 1 1| Alveolar Epithelium, Hyperplasia | 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Exudate | X X X X X X X X X X| Foreign Body | 3 2| Fungus | 3 3 3 4 3| Mucosa, Hyperplasia | 2 2 2 3 1 2 1 2| Mucosa, Metaplasia, Squamous | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | +| __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | Nephropathy | 2 1 3 2 1 1 4 2 3 3 3 1 2 2 2 2 2 1 2 1 2 1 2 1| Renal Tubule, Cytoplasmic Alteration | | Renal Tubule, Dilatation | 3 | Renal Tubule, Pigmentation | 2 1 1 2 2 2 2 3 1 2 2 1 2 4 1 1 1 1 1 2 2 3 1 3 2| Transitional Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Transitional Epithelium, Hyperplasia | 2 4 | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 1| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| | DAY ON TEST | 6| 5| 3| 1| 3| 1| 1| 3| 3| 7| 9| 0| 3| 8| 3| 3| 3| 3| 7| 1| 3| 0| 3| 3| 3| | | 3| 0| 1| 8| 0| 6| 6| 1| 1| 5| 3| 9| 0| 0| 0| 1| 0| 1| 7| 4| 0| 9| 9| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.2% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + M + + + + + + + + + + + + + + + + + + M +| 48 | Parasite Metazoan | X | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X X | 8 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 1 | Ulcer | | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 | 2 3.0| Basophilic Focus | X X X X X X X | 14 | Clear Cell Focus | X X X X X| 8 | Cyst | X | 2 | Degeneration, Cystic | 1 2 | 6 1.7| Eosinophilic Focus | X X X | 4 | Granuloma | 1 2 2 1| 7 1.6| Hemorrhage | | 1 3.0| Hepatodiaphragmatic Nodule | X X | 7 | Inflammation, Subacute | 3 | 4 1.8| Mixed Cell Focus | X X X | 7 | Bile Duct, Hyperplasia | 3 3 1 4 4 2 1 3 4 3 1 2 1| 27 2.4| Centrilobular, Necrosis | 3 | 2 2.5| Hepatocyte, Vacuolization Cytoplasmic| 3 | 4 3.3| Kupffer Cell, Pigmentation | 3 2 | 6 2.2| Lobules, Necrosis | | 1 1.0| __________________________________________________________________________|____________| Mesentery | + | 5 | Accessory Spleen | X | 1 | Fat, Necrosis | | 3 3.3| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 2 2 3 3 3 2 2 1 2 3 2 3 2 2 2 | 29 2.0| Acinus, Hyperplasia, Focal | 3 2 2 2 2 2 2 | 12 2.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 3 3.3| Ulcer | 2 | 3 3.0| Mucosa, Hyperplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 1| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| | DAY ON TEST | 6| 5| 3| 1| 3| 1| 1| 3| 3| 7| 9| 0| 3| 8| 3| 3| 3| 3| 7| 1| 3| 0| 3| 3| 3| | | 3| 0| 1| 8| 0| 6| 6| 1| 1| 5| 3| 9| 0| 0| 0| 1| 0| 1| 7| 4| 0| 9| 9| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.2% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 2 | 1 2.0| Ulcer | | 1 3.0| __________________________________________________________________________|____________| Tongue | +| 1 | Epithelium, Hyperplasia | 2| 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 3 3 1 2 3 3 2 3 1 3 3 3 2 1 2 | 34 2.1| Thrombosis | X | 5 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 1 1 1 2 | 6 1.3| Angiectasis | | 2 3.0| Degeneration, Fatty | 1 1 1 1 | 8 1.5| Hemorrhage | | 1 2.0| Hyperplasia, Focal | 2 3 2 | 4 2.0| Hypertrophy, Focal | 1 | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 1 1 2 1 1 | 12 1.4| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 | 2 1.5| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +| 49 | Pars Distalis, Cyst | X | 2 | Pars Distalis, Hyperplasia, Focal | 4 2 2 | 5 2.4| Pars Distalis, Hyperplasia | 4 | 2 3.0| Pars Distalis, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ultimobranchial Cyst | | 2 | C-Cell, Hyperplasia | 1 1 1 | 7 1.1| Follicle, Cyst | X X | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 1| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| | DAY ON TEST | 6| 5| 3| 1| 3| 1| 1| 3| 3| 7| 9| 0| 3| 8| 3| 3| 3| 3| 7| 1| 3| 0| 3| 3| 3| | | 3| 0| 1| 8| 0| 6| 6| 1| 1| 5| 3| 9| 0| 0| 0| 1| 0| 1| 7| 4| 0| 9| 9| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.2% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atypia Cellular | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 37 3.0| Hypospermia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 43 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 2 3 3 3 3 | 14 2.4| Hyperplasia | | 1 2.0| Inflammation, Chronic | 2 3 3 2 2 2 3 3 2 | 17 2.3| Inflammation, Suppurative | 3 3 2 | 6 2.5| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Corpora Amylacea | 2 2 2 3 2 3 2 2 2 2 1 1 2 3 3 2 1 2 2 | 30 2.1| Fibrosis | | 1 3.0| Inflammation, Suppurative | 1 3 3 2 3 1 1 1 1 1 2| 19 1.8| Epithelium, Hyperplasia | | 3 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 4 | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 2 2 1 2 | 6 1.5| Seminiferous Tubule, Atrophy | 4 | 4 3.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myelofibrosis | 2 2 2 3 2 | 5 2.2| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + | 19 | Mediastinal, Pigmentation | 3 3 4 | 5 3.4| Pancreatic, Hemorrhage | | 1 3.0| Pancreatic, Pigmentation | 3 | 2 3.0| Renal, Pigmentation | | 2 3.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 | 4 2.5| Hemorrhage | 1 2 | 6 1.5| Hyperplasia, Lymphoid | | 5 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 1 2.0| Hemorrhage | 2 | 4 2.3| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 3 3 | 10 3.0| Granuloma | 1 | 1 1.0| Hematopoietic Cell Proliferation | 2 2 3 3 3 | 7 2.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 1| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| | DAY ON TEST | 6| 5| 3| 1| 3| 1| 1| 3| 3| 7| 9| 0| 3| 8| 3| 3| 3| 3| 7| 1| 3| 0| 3| 3| 3| | | 3| 0| 1| 8| 0| 6| 6| 1| 1| 5| 3| 9| 0| 0| 0| 1| 0| 1| 7| 4| 0| 9| 9| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.2% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Pigmentation, Hemosiderin | 1 1 | 6 1.5| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + I + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 2 3 3 2 2 2 3 2 | 12 2.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 3 3 3 3 2 2| 10 2.6| Cyst Epithelial Inclusion | | 1 | Hemorrhage | | 1 2.0| Hyperkeratosis | 4 3 3 3 3 3 3 3| 13 3.1| Inflammation, Chronic | 2 | 2 2.0| Ulcer | 3 | 3 2.7| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Hyperostosis | | 1 3.0| Femur, Osteopetrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | 3 | 2 3.5| Gliosis | 3 | 1 3.0| Hemorrhage | 3 | 2 2.5| Hydrocephalus | | 1 2.0| Mineralization | 3 | 1 3.0| Necrosis | 3 | 2 3.0| Cerebellum, Necrosis | | 1 3.0| __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 | 1 3.0| Hemorrhage | 4 | 1 4.0| Infiltration Cellular, Histiocyte | 1 1 1 | 6 1.0| Alveolar Epithelium, Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Exudate | X X X X X X X | 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 1| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| | DAY ON TEST | 6| 5| 3| 1| 3| 1| 1| 3| 3| 7| 9| 0| 3| 8| 3| 3| 3| 3| 7| 1| 3| 0| 3| 3| 3| | | 3| 0| 1| 8| 0| 6| 6| 1| 1| 5| 3| 9| 0| 0| 0| 1| 0| 1| 7| 4| 0| 9| 9| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1.2% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Foreign Body | 3 2 2 | 5 2.4| Fungus | 3 2 2 3 3 2 | 11 2.8| Mucosa, Hyperplasia | 2 2 3 3 | 12 2.1| Mucosa, Metaplasia, Squamous | 2 | 2 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 2| 4 1.5| Nephropathy | 2 1 1 2 3 2 1 2 2 2 2 2 2 3 2 3 3 1 1 2 2 1 3 3| 48 2.0| Renal Tubule, Cytoplasmic Alteration | 2 | 1 2.0| Renal Tubule, Dilatation | | 1 3.0| Renal Tubule, Pigmentation | 2 4 2 3 1 2 3 2 1 1 2 3 2 1 1 2 1 2 3 2 1 2 2 2 2| 50 1.9| Transitional Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Transitional Epithelium, Hyperplasia | | 2 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3| 4| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 1| 1| 0| 1| 9| 1| 0| 1| 1| 0| 2| 1| 1| 9| 8| 1| 1| 0| 1| 1| 1| 0| 1| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| CONTROL | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | X X X X X X X X X X X | Clear Cell Focus | X X X X X | Degeneration, Cystic | 3 1 2 3 | Developmental Malformation | 3 | Eosinophilic Focus | X X X X X X | Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X X| Bile Duct, Hyperplasia | 1 1 1 2 1 1 2 3 2 2 2 1 1 2 1 1 1 | Hepatocyte, Vacuolization Cytoplasmic| 2 4 2 2 3| Lobules, Necrosis | 1 | __________________________________________________________________________| Mesentery | + + + + + + + | Accessory Spleen | | Fat, Necrosis | 2 3 3 3 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 2 3 1 1 3 1 1 2 3 1 2 1 2 1| Acinus, Cytoplasmic Alteration | | Acinus, Hyperplasia, Focal | 3 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | Mucosa, Hyperplasia | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Ulcer | 3 | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypertrophy | 3 | Inflammation, Subacute | 3 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3| 4| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 1| 1| 0| 1| 9| 1| 0| 1| 1| 0| 2| 1| 1| 9| 8| 1| 1| 0| 1| 1| 1| 0| 1| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| CONTROL | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Cardiomyopathy | 3 1 2 2 2 2 2 3 3 2 2 2 2 1 1 | Inflammation, Chronic | 3 | Schwann Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 1 2 1 1 3 1 2 | Angiectasis | 2 2 2 1 1 2 1| Degeneration, Fatty | 2 | Hemorrhage | | Hyperplasia, Focal | 1 1 2 1 1 | Hypertrophy, Focal | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | | Pars Distalis, Cyst | X| Pars Distalis, Hyperplasia, Focal | 1 1 1 2 | Pars Intermedia, Angiectasis | 3 | Pars Intermedia, Cyst | X | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 4 | Ultimobranchial Cyst | X | C-Cell, Hyperplasia | 1 2 1 1 1 1 | Follicular Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Atypia Cellular | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| Hypospermia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 3 2 2 3 3 2 | Hyperplasia | 2 | Inflammation, Chronic | 2 2 2 2 2 3 3 2 2 2 2| Inflammation, Suppurative | 2 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Corpora Amylacea | 3 3 2 3 1 3 2 2 2 2 1 2 3 2 | Inflammation, Suppurative | 3 1 1 2 2 3 1 2 1 1 2 1 1| _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3| 4| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 1| 1| 0| 1| 9| 1| 0| 1| 1| 0| 2| 1| 1| 9| 8| 1| 1| 0| 1| 1| 1| 0| 1| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| CONTROL | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 1 1 2 2 | Seminiferous Tubule, Atrophy | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypercellularity | | Myelofibrosis | 3 | __________________________________________________________________________| Lymph Node | + + + + | Mediastinal, Hemorrhage | 3 3 | Mediastinal, Hyperplasia, Lymphoid | | Mediastinal, Pigmentation | 3 3 4 | Pancreatic, Hyperplasia, Lymphoid | | Pancreatic, Pigmentation | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +| Ectasia | 2 | Hemorrhage | 1 1 1| Hyperplasia, Lymphoid | 3 2 | Pigmentation | 2 2 2 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | 2 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 3 | Hematopoietic Cell Proliferation | 2 3 2 | Necrosis | | Pigmentation, Hemosiderin | 1 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 | Cyst Epithelial Inclusion | | Hyperkeratosis | 3 | Inflammation, Chronic | 4 | Ulcer | | Subcutaneous Tissue, Inflammation, | | Chronic | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3| 4| 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 1| 1| 0| 1| 9| 1| 0| 1| 1| 0| 2| 1| 1| 9| 8| 1| 1| 0| 1| 1| 1| 0| 1| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| CONTROL | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Femur, Osteopetrosis | 2 | __________________________________________________________________________| Skeletal Muscle | + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | | Hydrocephalus | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Hemorrhage | | Infiltration Cellular, Histiocyte | 1 4 1 2 1 1 1 1 | Inflammation, Subacute | 2 | Inflammation, Suppurative | 3 | Alveolar Epithelium, Hyperplasia | 2 1 2 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Exudate | X X X X | Foreign Body | 2 | Fungus | 2 2 3 3 | Mucosa, Hyperplasia | 2 3 | Mucosa, Metaplasia, Squamous | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Mineralization | | Nephropathy | 2 1 2 1 1 2 3 1 2 2 1 1 3 1 3 1 2 1 2 1 1 1 1 1 2| Renal Tubule, Cytoplasmic Alteration | | Renal Tubule, Hyaline Droplet | | Renal Tubule, Necrosis | | Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 2 2 2 1 1 1 1 1 1 2 1 1 2 1 1 2 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 4| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 4| | DAY ON TEST | 3| 8| 3| 7| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 1| 6| 0| 3| 2| | | 1| 4| 1| 9| 4| 9| 0| 1| 1| 0| 9| 1| 1| 0| 1| 1| 0| 2| 2| 1| 9| 9| 7| 9| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| L | FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| 7| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + I + + + + + + + + + + + + +| 48 | Parasite Metazoan | X X X | 6 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 3 2 2 | 4 2.3| Basophilic Focus | X X X X X X X X X | 20 | Clear Cell Focus | X X X | 8 | Degeneration, Cystic | 2 3 3 | 7 2.4| Developmental Malformation | | 1 3.0| Eosinophilic Focus | X X X X | 10 | Hematopoietic Cell Proliferation | 1 | 1 1.0| Hepatodiaphragmatic Nodule | X X | 4 | Mixed Cell Focus | X X X X | 6 | Bile Duct, Hyperplasia | 1 2 1 2 1 1 1 1 3 3 2 3 3 1 3 1 3 | 34 1.7| Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 3 | 9 2.8| Lobules, Necrosis | 1 | 2 1.0| __________________________________________________________________________|____________| Mesentery | + + + + | 11 | Accessory Spleen | X | 1 | Fat, Necrosis | 3 3 3 | 8 2.9| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 1 3 2 2 2 2 2 1 1 1 3 1 3 | 31 1.7| Acinus, Cytoplasmic Alteration | 2 | 1 2.0| Acinus, Hyperplasia, Focal | | 2 2.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 4 | 1 4.0| Mucosa, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 1 2.0| Ulcer | | 1 3.0| __________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 4| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 4| | DAY ON TEST | 3| 8| 3| 7| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 1| 6| 0| 3| 2| | | 1| 4| 1| 9| 4| 9| 0| 1| 1| 0| 9| 1| 1| 0| 1| 1| 0| 2| 2| 1| 9| 9| 7| 9| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| L | FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| 7| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypertrophy | 3 | 2 3.0| Inflammation, Subacute | 3 | 2 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 1 3 2 2 1 3 2 3 2 | 24 2.0| Inflammation, Chronic | | 1 3.0| Schwann Cell, Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 3 2 2 | 10 1.8| Angiectasis | 1 | 8 1.5| Degeneration, Fatty | 4 2 | 3 2.7| Hemorrhage | 2 | 1 2.0| Hyperplasia, Focal | 2 3 2 2 | 9 1.7| Hypertrophy, Focal | 2 1 1 | 3 1.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 3 3 2 | 6 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + + + + + + M + + + + + + + + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 2 2 3 | 3 2.3| Pars Distalis, Cyst | X X | 3 | Pars Distalis, Hyperplasia, Focal | 1 3 2 3 1 | 9 1.7| Pars Intermedia, Angiectasis | 3 | 2 3.0| Pars Intermedia, Cyst | | 1 | Pars Intermedia, Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 4.0| Ultimobranchial Cyst | | 1 | C-Cell, Hyperplasia | 1 1 1 2 1 3 | 12 1.3| Follicular Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 4| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 4| | DAY ON TEST | 3| 8| 3| 7| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 1| 6| 0| 3| 2| | | 1| 4| 1| 9| 4| 9| 0| 1| 1| 0| 9| 1| 1| 0| 1| 1| 0| 2| 2| 1| 9| 9| 7| 9| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| L | FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| 7| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Atypia Cellular | 3 3 3 3 3 3 3 3 3 3 3 3 3 X| 30 3.0| Hypospermia | 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | 40 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 3 2 | 9 2.6| Hyperplasia | 3 | 2 2.5| Inflammation, Chronic | 2 2 2 2 2 2 2 2 4 2 | 21 2.2| Inflammation, Suppurative | 2 3 2 | 5 2.2| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Corpora Amylacea | 2 2 X 3 2 3 3 3 2 2| 24 2.3| Inflammation, Suppurative | 3 1 3 2 1 1 3 3 1 2 2 3 2 2| 27 1.9| Epithelium, Hyperplasia | 1 3 2 2 | 5 1.8| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 1 | 5 1.4| Seminiferous Tubule, Atrophy | 3 | 2 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypercellularity | 4 2 | 2 3.0| Myelofibrosis | 2 3 | 3 2.7| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + +| 14 | Mediastinal, Hemorrhage | 2 3| 4 2.8| Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0| Mediastinal, Pigmentation | 2 | 4 3.0| Pancreatic, Hyperplasia, Lymphoid | 2 | 1 2.0| Pancreatic, Pigmentation | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 | Ectasia | 3 3 3 | 4 2.8| Hemorrhage | 2 1 1 2 2| 8 1.4| Hyperplasia, Lymphoid | 2 2 3 | 5 2.4| Pigmentation | 2 2 2 | 7 2.1| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 | 1 2.0| Hemorrhage | 3| 3 2.7| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 2 2 3 2 | 7 2.6| Hematopoietic Cell Proliferation | 3 1 1 | 6 2.0| Necrosis | 4 | 1 4.0| Pigmentation, Hemosiderin | 2 | 2 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 4| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 4| | DAY ON TEST | 3| 8| 3| 7| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 1| 6| 0| 3| 2| | | 1| 4| 1| 9| 4| 9| 0| 1| 1| 0| 9| 1| 1| 0| 1| 1| 0| 2| 2| 1| 9| 9| 7| 9| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| L | FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| 7| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | + M + + + + + + + + + + + + + + + + + + + + M + +| 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 4 3 1 2 2 | 8 2.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | | 1 3.0| Cyst Epithelial Inclusion | X | 1 | Hyperkeratosis | | 1 3.0| Inflammation, Chronic | | 1 4.0| Ulcer | 4 | 1 4.0| Subcutaneous Tissue, Inflammation, | | | Chronic | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femur, Osteopetrosis | 3 | 2 2.5| __________________________________________________________________________|____________| Skeletal Muscle | +| 4 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | 4 X 4 4 | 4 4.0| Hydrocephalus | 2 3 | 2 2.5| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Hemorrhage | 3| 1 3.0| Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 | 15 1.3| Inflammation, Subacute | | 1 2.0| Inflammation, Suppurative | | 1 3.0| Alveolar Epithelium, Hyperplasia | 1 1 | 6 1.8| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Exudate | X X X X X X X | 11 | Foreign Body | 2 3 | 3 2.3| Fungus | 4 1 2 3 4 2 | 10 2.6| Mucosa, Hyperplasia | 2 2 2 2 2 3 | 8 2.3| Mucosa, Metaplasia, Squamous | 2 1 2 3 | 5 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 05094-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/24/95 Route: DOSED FEED Time: 10:49:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 4| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 3| 4| | DAY ON TEST | 3| 8| 3| 7| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 1| 6| 0| 3| 2| | | 1| 4| 1| 9| 4| 9| 0| 1| 1| 0| 9| 1| 1| 0| 1| 1| 0| 2| 2| 1| 9| 9| 7| 9| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| L | FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 2| 7| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | + + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 1.0| Mineralization | 1 | 1 1.0| Nephropathy | 3 1 2 2 4 1 2 3 2 1 1 2 2 1 1 3 2 1 1 1 1 1 1 | 48 1.6| Renal Tubule, Cytoplasmic Alteration | 3 3| 2 3.0| Renal Tubule, Hyaline Droplet | 3 | 1 3.0| Renal Tubule, Necrosis | 1 | 1 1.0| Renal Tubule, Pigmentation | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 3 2 1 3 1 1 1 1| 49 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------