TDMS Study 05094-99 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: SOUTHERN RESEARCH INST BUTYL BENZYL PHTHALATE DATE: 05/10/95
EXPERIMENT: 05094 TEST: 99 TIME: 17:28:46
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85222 ROUTE: DOSED FEED NTP C#: 54375C
PATHOLOGIST: DR J. E. HEATH CAS: 85-68-7
------------------------------------------------------------------------------------------------------------------------------------
05094/02 -VS- 05094/03 COMPARISON
REASONS FOR REMOVAL: 25022 Accidently Killed
25004 Dead
25005 Interval Sacrifice
25003 Moribund
25019 Moribund Sacrifice
25020 Natural Death
25026 Other
25017 Scheduled Sacrifice
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 AD LIB CONTROL
INCLUDE 002 AD LIB CONTROL
INCLUDE 005 RTD CONTROL
INCLUDE 006 RTD CONTROL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: SOUTHERN RESEARCH INST BUTYL BENZYL PHTHALATE DATE: 05/10/95
EXPERIMENT: 05094 TEST: 99 TIME: 17:28:46
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85222 ROUTE: DOSED FEED NTP C#: 54375C
PATHOLOGIST: DR J. E. HEATH CAS: 85-68-7
BUTYL BENZYL PHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = AD LIB CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 255 261 438 477 479 541 544 557 562 576 |
| 593 607 611 614 631 631 644 662 677 717 |
| 718 718 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = RTD CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 10 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 432 467 507 549 583 600 645 645 655 681 |
| 682 696 709 719 723 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
BUTYL BENZYL PHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|AD | 100.0 100.0 96.7 96.7 96.7 91.0 86.9 78.8 64.7 56.6 |
|LIB CONTRO| |
| | |
|RTD | 100.0 100.0 100.0 100.0 100.0 96.3 94.3 88.3 82.3 70.2 |
|CONTROL | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| AD RTD |
| LIB CONTROL CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.6% 70.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 568.8 619.5 |
|NATURAL DEATHS (C) | (26.9) (24.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 625.1 656.3 |
|(STANDARD ERROR) | (16.7) (14.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BUTYL BENZYL PHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = AD LIB CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 25 CENSORED DEATHS 10 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 39 368 512 570 587 598 668 670 681 684 |
| 691 702 702 703 711 713 716 717 717 717 |
| 719 725 725 725 726 |
| CENSORED DEATHS |
| 459 459 459 459 459 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = RTD CONTROL |
| ---------------------------- |
| |
| TOTAL 62 UNCENSORED DEATHS 17 CENSORED DEATHS 45 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 324 359 551 564 597 616 624 625 674 677 |
| 684 687 687 696 705 705 712 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| 730 730 730 730 730 730 730 730 730 730 |
| 730 730 730 730 730 730 730 730 730 730 |
| 730 731 731 731 731 731 731 731 731 731 |
| 731 731 731 731 731 |
| |
==================================================================================
BUTYL BENZYL PHTHALATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|AD | 98.3 98.3 98.3 98.3 96.7 96.7 94.7 88.6 88.6 50.3 |
|LIB CONTRO| |
| | |
|RTD | 100.0 100.0 100.0 96.8 96.8 96.8 96.8 91.0 85.2 67.7 |
|CONTROL | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| AD RTD |
| LIB CONTROL CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 50.3% 67.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 643.4 616.9 |
|NATURAL DEATHS (C) | (30.3) (27.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 651.3 655.2 |
|(STANDARD ERROR) | (17.6) (14.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BUTYL BENZYL PHTHALATE
KAPLAN-MEIER SURVIVAL CURVES
AD LIB CONTROL = 1
RTD CONTROL = 2
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2
| 11 2 2
|
| 1 1 2 2
95 + 1 1
| 2 2
| 2 2
| 1 1
90 + 2 2
| 2 2
P | 1 1
E |
R 85 + 11
C | 22
E | 1 1 2 2
N | 1 1
T 80 +
| 1 1 2 2
S |
U | 11 2 2
R 75 +
V | 22
I | 1 1 22
V |
A 70 + 2 2
L | 11
|
| 1 1
65 + 1 1
|
| 1 1
|
60 +
|
|
| 1 1
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 1 obs hidden.
BUTYL BENZYL PHTHALATE
KAPLAN-MEIER SURVIVAL CURVES
AD LIB CONTROL = 1
RTD CONTROL = 2
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2
| 1 2 21
|
| 21 1 2
95 + 1 2 21
|
| 21 1 2
| 1 1 2
90 +
| 1 2 2 1
|
|
P 85 + 2 121
E |
R |
C | 22
E 80 + 11
N | 21 1
T |
|
S 75 + 22
U | 22
R | 11
V |
I 70 + 22
V | 11
A | 2 2
L |
65 +
|
|
|
60 +
| 11
|
|
55 +
|
|
|
50 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.