TDMS Study 05099-09 Pathology Tables
NEOPLASMS BY INDIVIDUAL ANIMAL
SALICYLAZOSULFAPYRIDINE
NTP Experiment-Test: 05099-09 Report: PEIRPT04
Study Type: CHRONIC Date: 04/17/95
Route: GAVAGE Time: 16:39:49
3 YEAR CORE
Facility: Southern Research Institute
Chemical CAS #: 599-79-1
Lock Date: 04/08/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25018 Dosing Accident
25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 MG/KG
Include 002 337.5 MG/KG
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
_____________________________________________________________________________________________________________________
| 8| 7| 8| 0| 8| 8| 7| 9| 3| 7| 9| 5| 8| 4| 7| 9| 5| 9| 8| 8| 7| 9| 8| 5| 7|
DAY ON TEST | 0| 0| 1| 3| 0| 4| 1| 1| 2| 1| 1| 9| 7| 4| 7| 1| 5| 1| 2| 4| 5| 1| 1| 7| 5|
| 9| 4| 6| 8| 9| 7| 7| 0| 7| 6| 0| 4| 5| 5| 0| 0| 6| 0| 6| 0| 8| 0| 6| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Chordoma, Metastatic, Bone | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Hepatocellular Adenoma | X X |
Leukemia Mononuclear | X X X X X X X X X X X X X X|
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X |
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Osteosarcoma, Metastatic, Bone | X |
Acinar Cell, Adenoma | X |
__________________________________________________________________________|
Pharynx | + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
_____________________________________________________________________________________________________________________
| 8| 7| 8| 0| 8| 8| 7| 9| 3| 7| 9| 5| 8| 4| 7| 9| 5| 9| 8| 8| 7| 9| 8| 5| 7|
DAY ON TEST | 0| 0| 1| 3| 0| 4| 1| 1| 2| 1| 1| 9| 7| 4| 7| 1| 5| 1| 2| 4| 5| 1| 1| 7| 5|
| 9| 4| 6| 8| 9| 7| 7| 0| 7| 6| 0| 4| 5| 5| 0| 0| 6| 0| 6| 0| 8| 0| 6| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
_____________________________________________________________________________________________________________________
| 8| 7| 8| 0| 8| 8| 7| 9| 3| 7| 9| 5| 8| 4| 7| 9| 5| 9| 8| 8| 7| 9| 8| 5| 7|
DAY ON TEST | 0| 0| 1| 3| 0| 4| 1| 1| 2| 1| 1| 9| 7| 4| 7| 1| 5| 1| 2| 4| 5| 1| 1| 7| 5|
| 9| 4| 6| 8| 9| 7| 7| 0| 7| 6| 0| 4| 5| 5| 0| 0| 6| 0| 6| 0| 8| 0| 6| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X X X X X X X|
Mediastinal, Osteosarcoma, | |
Metastatic, Bone | X |
Pancreatic, Leukemia Mononuclear | X X X X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M M + + + M + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Keratoacanthoma | X |
Squamous Cell Papilloma | X X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Chordoma | |
Osteosarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | + + |
Leukemia Mononuclear | X |
Osteosarcoma, Metastatic, Bone | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
_____________________________________________________________________________________________________________________
| 8| 7| 8| 0| 8| 8| 7| 9| 3| 7| 9| 5| 8| 4| 7| 9| 5| 9| 8| 8| 7| 9| 8| 5| 7|
DAY ON TEST | 0| 0| 1| 3| 0| 4| 1| 1| 2| 1| 1| 9| 7| 4| 7| 1| 5| 1| 2| 4| 5| 1| 1| 7| 5|
| 9| 4| 6| 8| 9| 7| 7| 0| 7| 6| 0| 4| 5| 5| 0| 0| 6| 0| 6| 0| 8| 0| 6| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
Fibrous Histiocytoma, Metastatic, | |
Skin | X |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
__________________________________________________________________________________________________________________________________
| 8| 8| 9| 6| 8| 9| 8| 8| 7| 7| 8| 7| 7| 6| 9| 6| 8| 4| 9| 8| 7| 9| 6| 9| | |
DAY ON TEST | 6| 6| 1| 5| 6| 1| 9| 1| 9| 6| 8| 9| 5| 9| 1| 2| 9| 6| 1| 1| 8| 1| 6| 0| | |
| 9| 9| 0| 9| 8| 0| 7| 6| 9| 3| 3| 4| 2| 0| 0| 3| 7| 2| 0| 5| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0 MG/KG | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Chordoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Hepatocellular Adenoma | X | 3 |
Leukemia Mononuclear | X X X X X X X X X X | 24 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + | 14 |
Leukemia Mononuclear | X | 3 |
Mesothelioma Malignant | | 1 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X X | 7 |
Osteosarcoma, Metastatic, Bone | | 1 |
Acinar Cell, Adenoma | X | 2 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
__________________________________________________________________________________________________________________________________
| 8| 8| 9| 6| 8| 9| 8| 8| 7| 7| 8| 7| 7| 6| 9| 6| 8| 4| 9| 8| 7| 9| 6| 9| | |
DAY ON TEST | 6| 6| 1| 5| 6| 1| 9| 1| 9| 6| 8| 9| 5| 9| 1| 2| 9| 6| 1| 1| 8| 1| 6| 0| | |
| 9| 9| 0| 9| 8| 0| 7| 6| 9| 3| 3| 4| 2| 0| 0| 3| 7| 2| 0| 5| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0 MG/KG | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Adenoma | X | 1 |
Leukemia Mononuclear | X X X X | 12 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X | 9 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X X X X X X X | 10 |
Bilateral, Pheochromocytoma Benign | X X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Adenoma | X X | 4 |
Carcinoma | X X X | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X X | 7 |
Pars Distalis, Adenoma | X X X X X X | 14 |
Pars Distalis, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
C-Cell, Adenoma | X X X X | 6 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Adenoma | X X | 2 |
Carcinoma | X X X | 4 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
__________________________________________________________________________________________________________________________________
| 8| 8| 9| 6| 8| 9| 8| 8| 7| 7| 8| 7| 7| 6| 9| 6| 8| 4| 9| 8| 7| 9| 6| 9| | |
DAY ON TEST | 6| 6| 1| 5| 6| 1| 9| 1| 9| 6| 8| 9| 5| 9| 1| 2| 9| 6| 1| 1| 8| 1| 6| 0| | |
| 9| 9| 0| 9| 8| 0| 7| 6| 9| 3| 3| 4| 2| 0| 0| 3| 7| 2| 0| 5| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0 MG/KG | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 2 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X X | 39 |
Interstitial Cell, Adenoma | X | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X X X X X X X X | 21 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 20 |
Axillary, Leukemia Mononuclear | X | 1 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | X | 1 |
Mediastinal, Leukemia Mononuclear | X X X | 10 |
Mediastinal, Osteosarcoma, | | |
Metastatic, Bone | | 1 |
Pancreatic, Leukemia Mononuclear | X X X X | 8 |
Renal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + | 48 |
Leukemia Mononuclear | X X X X X X | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X X X X | 11 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X X X X X X X X | 23 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + M + + + + + | 44 |
Leukemia Mononuclear | X X X | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Fibroadenoma | X | 2 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Basal Cell Carcinoma | X | 1 |
Keratoacanthoma | X | 2 |
Squamous Cell Papilloma | | 2 |
Subcutaneous Tissue, Fibroma | X X X X | 5 |
Subcutaneous Tissue, Fibrosarcoma | X X | 3 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
__________________________________________________________________________________________________________________________________
| 8| 8| 9| 6| 8| 9| 8| 8| 7| 7| 8| 7| 7| 6| 9| 6| 8| 4| 9| 8| 7| 9| 6| 9| | |
DAY ON TEST | 6| 6| 1| 5| 6| 1| 9| 1| 9| 6| 8| 9| 5| 9| 1| 2| 9| 6| 1| 1| 8| 1| 6| 0| | |
| 9| 9| 0| 9| 8| 0| 7| 6| 9| 3| 3| 4| 2| 0| 0| 3| 7| 2| 0| 5| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0 MG/KG | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Chordoma | X | 1 |
Osteosarcoma | X | 2 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Leukemia Mononuclear | | 1 |
Osteosarcoma, Metastatic, Bone | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Alveolar/Bronchiolar Carcinoma | X X | 2 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | | 1 |
Leukemia Mononuclear | X X X X X X X X X | 20 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 4 |
__________________________________________________________________________|____________|
Zymbal's Gland | + + | 2 |
Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X X X X X | 12 |
__________________________________________________________________________|____________|
Urethra | + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X X X X X X X X X | 24 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
__________________________________________________________________________________________________________________________________
| 8| 8| 9| 6| 8| 9| 8| 8| 7| 7| 8| 7| 7| 6| 9| 6| 8| 4| 9| 8| 7| 9| 6| 9| | |
DAY ON TEST | 6| 6| 1| 5| 6| 1| 9| 1| 9| 6| 8| 9| 5| 9| 1| 2| 9| 6| 1| 1| 8| 1| 6| 0| | |
| 9| 9| 0| 9| 8| 0| 7| 6| 9| 3| 3| 4| 2| 0| 0| 3| 7| 2| 0| 5| 0| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0 MG/KG | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
_____________________________________________________________________________________________________________________
| 9| 8| 5| 9| 9| 9| 7| 6| 8| 9| 9| 9| 9| 7| 9| 1| 9| 7| 5| 9| 9| 9| 9| 9| 8|
DAY ON TEST | 1| 4| 7| 1| 1| 1| 9| 3| 3| 1| 1| 1| 1| 5| 1| 2| 1| 9| 7| 1| 1| 1| 1| 1| 2|
| 0| 0| 4| 0| 0| 0| 0| 4| 2| 0| 0| 0| 0| 0| 0| 0| 0| 5| 1| 0| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
337.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma, Metastatic, | |
Skin | |
Hepatocellular Carcinoma | |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | + + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Spleen | X |
Leukemia Mononuclear | X |
Acinar Cell, Adenoma | X X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M|
Parotid Gland, Fibrosarcoma | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
_____________________________________________________________________________________________________________________
| 9| 8| 5| 9| 9| 9| 7| 6| 8| 9| 9| 9| 9| 7| 9| 1| 9| 7| 5| 9| 9| 9| 9| 9| 8|
DAY ON TEST | 1| 4| 7| 1| 1| 1| 9| 3| 3| 1| 1| 1| 1| 5| 1| 2| 1| 9| 7| 1| 1| 1| 1| 1| 2|
| 0| 0| 4| 0| 0| 0| 0| 4| 2| 0| 0| 0| 0| 0| 0| 0| 0| 5| 1| 0| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
337.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Bilateral, C-Cell, Carcinoma | X |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | X |
Mediastinal, Fibrous Histiocytoma, | |
Metastatic, Skin | |
Mediastinal, Histiocytic Sarcoma, | |
Metastatic, Spleen | X |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Fibrous Histiocytoma, | |
Metastatic, Skin | |
Renal, Histiocytic Sarcoma, | |
Metastatic, Spleen | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
_____________________________________________________________________________________________________________________
| 9| 8| 5| 9| 9| 9| 7| 6| 8| 9| 9| 9| 9| 7| 9| 1| 9| 7| 5| 9| 9| 9| 9| 9| 8|
DAY ON TEST | 1| 4| 7| 1| 1| 1| 9| 3| 3| 1| 1| 1| 1| 5| 1| 2| 1| 9| 7| 1| 1| 1| 1| 1| 2|
| 0| 0| 4| 0| 0| 0| 0| 4| 2| 0| 0| 0| 0| 0| 0| 0| 0| 5| 1| 0| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
337.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thymus | M + + + + + M + + + + + + + + + + + + + + M I I M|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + M + + + + + + + + + M +|
Carcinoma | |
Fibroadenoma | X |
Fibrous Histiocytoma, Metastatic, | |
Skin | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Squamous Cell Papilloma | X X |
Trichoepithelioma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
Subcutaneous Tissue, Schwannoma NOS | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Fibrous Histiocytoma, Metastatic, | |
Skin | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Oligodendroglioma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + M|
Carcinoma, Metastatic, Thyroid Gland | X |
Fibrous Histiocytoma, Metastatic, | |
Skin | |
Histiocytic Sarcoma, Metastatic, | |
Spleen | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M|
Carcinoma, Metastatic, Thyroid Gland | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
_____________________________________________________________________________________________________________________
| 9| 8| 5| 9| 9| 9| 7| 6| 8| 9| 9| 9| 9| 7| 9| 1| 9| 7| 5| 9| 9| 9| 9| 9| 8|
DAY ON TEST | 1| 4| 7| 1| 1| 1| 9| 3| 3| 1| 1| 1| 1| 5| 1| 2| 1| 9| 7| 1| 1| 1| 1| 1| 2|
| 0| 0| 4| 0| 0| 0| 0| 4| 2| 0| 0| 0| 0| 0| 0| 0| 0| 5| 1| 0| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
337.5 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Spleen | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
__________________________________________________________________________________________________________________________________
| 8| 9| 6| 8| 9| 7| 9| 9| 9| 5| 9| 1| 8| 8| 9| 8| 8| 8| 7| 2| 9| 9| 8| 8| 4| |
DAY ON TEST | 1| 1| 9| 4| 1| 3| 1| 1| 1| 7| 1| 9| 5| 7| 1| 8| 7| 7| 9| 0| 1| 1| 1| 7| 3| |
| 6| 0| 5| 5| 0| 7| 0| 0| 0| 3| 0| 9| 4| 5| 0| 9| 5| 8| 3| 0| 0| 0| 2| 7| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
337.5 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 9| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + M + + + + + + + + M + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + M + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | X | 1 |
Hepatocellular Carcinoma | X | 1 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X| 7 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | X X X | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + M + + + + + + + + + + M +| 48 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 1 |
Leukemia Mononuclear | | 1 |
Acinar Cell, Adenoma | | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parotid Gland, Fibrosarcoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X| 3 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
Pheochromocytoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
__________________________________________________________________________________________________________________________________
| 8| 9| 6| 8| 9| 7| 9| 9| 9| 5| 9| 1| 8| 8| 9| 8| 8| 8| 7| 2| 9| 9| 8| 8| 4| |
DAY ON TEST | 1| 1| 9| 4| 1| 3| 1| 1| 1| 7| 1| 9| 5| 7| 1| 8| 7| 7| 9| 0| 1| 1| 1| 7| 3| |
| 6| 0| 5| 5| 0| 7| 0| 0| 0| 3| 0| 9| 4| 5| 0| 9| 5| 8| 3| 0| 0| 0| 2| 7| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
337.5 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 9| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | X X X | 6 |
Bilateral, Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + M +| 48 |
Adenoma | X | 4 |
Carcinoma | X X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Pars Distalis, Adenoma | X X X X | 12 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bilateral, C-Cell, Carcinoma | | 1 |
C-Cell, Adenoma | X X | 5 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Adenoma | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X | 37 |
Interstitial Cell, Adenoma | X X| 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 10 |
Deep Cervical, Carcinoma, Metastatic,| | |
Thyroid Gland | | 1 |
Mediastinal, Fibrous Histiocytoma, | | |
Metastatic, Skin | X | 1 |
Mediastinal, Histiocytic Sarcoma, | | |
Metastatic, Spleen | | 1 |
Mediastinal, Leukemia Mononuclear | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
__________________________________________________________________________________________________________________________________
| 8| 9| 6| 8| 9| 7| 9| 9| 9| 5| 9| 1| 8| 8| 9| 8| 8| 8| 7| 2| 9| 9| 8| 8| 4| |
DAY ON TEST | 1| 1| 9| 4| 1| 3| 1| 1| 1| 7| 1| 9| 5| 7| 1| 8| 7| 7| 9| 0| 1| 1| 1| 7| 3| |
| 6| 0| 5| 5| 0| 7| 0| 0| 0| 3| 0| 9| 4| 5| 0| 9| 5| 8| 3| 0| 0| 0| 2| 7| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
337.5 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 9| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Fibrous Histiocytoma, | | |
Metastatic, Skin | X | 1 |
Renal, Histiocytic Sarcoma, | | |
Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + M + + +| 48 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X| 6 |
__________________________________________________________________________|____________|
Thymus | + + + + M + M + + + + + + M M + + + + + + + + + +| 40 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Carcinoma | X | 1 |
Fibroadenoma | X | 2 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | | 1 |
Squamous Cell Papilloma | X | 3 |
Trichoepithelioma | X | 2 |
Subcutaneous Tissue, Fibroma | X X X X | 5 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | X X | 2 |
Subcutaneous Tissue, Schwannoma NOS | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | X | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05099-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/17/95
Route: GAVAGE Time: 16:39:49
__________________________________________________________________________________________________________________________________
| 8| 9| 6| 8| 9| 7| 9| 9| 9| 5| 9| 1| 8| 8| 9| 8| 8| 8| 7| 2| 9| 9| 8| 8| 4| |
DAY ON TEST | 1| 1| 9| 4| 1| 3| 1| 1| 1| 7| 1| 9| 5| 7| 1| 8| 7| 7| 9| 0| 1| 1| 1| 7| 3| |
| 6| 0| 5| 5| 0| 7| 0| 0| 0| 3| 0| 9| 4| 5| 0| 9| 5| 8| 3| 0| 0| 0| 2| 7| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
337.5 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 9| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X| 1 |
Oligodendroglioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Fibrous Histiocytoma, Metastatic, | | |
Skin | X | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 1 |
Leukemia Mononuclear | X X| 4 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma, Metastatic, | | |
Spleen | | 1 |
Leukemia Mononuclear | X| 3 |
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urethra | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Papilloma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X| 8 |
Mesothelioma Malignant | X X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
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---------- END OF REPORT ----------
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