TDMS Study 05099-99 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: SOUTHERN RESEARCH INST DATE: 05/08/95
EXP: 05099 SALICYLAZOSULFAPYRIDINE TIME: 12:01:01
TEST: 99 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 61552B
CONT: N01-ES-85233 CAS: 599-79-1
PATHOLOGIST: R.B. THOMPSON
--------------------------------------------------------------------------------
05099/08 -VS- 05099/10 COMPARISON
REASONS FOR REMOVAL:
25022 Accidently Killed
25018 Dosing Accident
25005 Interval Sacrifice
25019 Moribund Sacrifice
25020 Natural Death
25017 Scheduled Sacrifice
25021 Terminal Sacrifice
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE 001 0 MG/KG
INCLUDE 004 RTD 0 MG/KG
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: SOUTHERN RESEARCH INST DATE: 05/08/95
EXP: 05099 SALICYLAZOSULFAPYRIDINE TIME: 12:01:01
TEST: 99 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 61552B
CONT: N01-ES-85233 CAS: 599-79-1
PATHOLOGIST: R.B. THOMPSON
SALICYLAZOSULFAPYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 8 CENSORED DEATHS 12 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 420 420 610 611 658 662 666 689 |
| CENSORED DEATHS |
| 150 351 456 456 456 456 456 456 456 456 |
| 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = RTD 0 MG/KG |
| ---------------------------- |
| |
| TOTAL 62 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 495 603 616 632 647 660 661 717 722 723 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
SALICYLAZOSULFAPYRIDINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 728 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 728 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 96.6 96.6 96.6 96.6 88.2 84.0 |
| | |
| | |
|RTD | 100.0 100.0 100.0 100.0 100.0 100.0 98.1 96.2 86.5 80.8 |
|0 MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG RTD |
| 0 MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 84.0% 80.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 592.0 647.6 |
|NATURAL DEATHS (C) | (38.7) (21.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 648.6 671.3 |
|(STANDARD ERROR) | (17.4) (13.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SALICYLAZOSULFAPYRIDINE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
RTD 0 MG/KG = 2
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2
|
|
|
98 + 2 2
|
|
| 1 1
96 + 22
|
|
|
P 94 + 2 2
E |
R |
C | 1 2 21
E 92 +
N |
T |
| 21 1
S 90 +
U |
R |
V |
I 88 + 11
V |
A |
L | 2 2
86 + 1 1
|
|
| 22
84 + 1 1
|
|
|
82 +
|
| 2
|
80 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 2 obs hidden.