TDMS Study 05099-98 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
SALICYLAZOSULFAPYRIDINE
NTP Experiment-Test: 05099-98 Report: PEIRPT05
Study Type: CHRONIC Date: 05/10/95
Route: GAVAGE Time: 11:56:50
05099/07 -VS- 05099/09 COMPARISON
Facility: SOUTHERN RESEARCH INSTITUTE
Chemical CAS #: 599-79-1
Lock Date: 02/03/93
Cage Range: All
Reasons For Removal: 25004 Dead 25018 Dosing Accident
25014 Gavage Death 25005 Interval Sacrifice
25003 Moribund 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 MG/KG AD LIB
Include 004 0 MG/KG RTD
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05099-98 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 05/10/95
Route: GAVAGE Time: 11:56:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0 MG/KG
AD LIB RTD
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DISPOSITION SUMMARY
Animals Initially in Study 70 110
Scheduled Sacrifice 33
Early Deaths
Moribund Sacrifice 13
Natural Death 1
Dosing Accident 1
Gavage Death 2
Moribund 13
Dead 2
Survivors
Terminal Sacrifice 35
Animals Examined Microscopically 50 50
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ALIMENTARY SYSTEM
Intestine Small, Jejunum (50) (50)
Adenoma 1 (2%)
Intestine Small, Ileum (49) (49)
Leiomyosarcoma 1 (2%)
Liver (50) (50)
Hepatocellular Adenoma 2 (4%) 1 (2%)
Leiomyosarcoma, Metastatic, Stomach,
Forestomach 1 (2%)
Mesentery (17) (20)
Fibrous Histiocytoma 1 (6%)
Leiomyosarcoma, Metastatic, Stomach,
Forestomach 1 (6%)
Pancreas (50) (50)
Fibrous Histiocytoma 1 (2%)
Leiomyosarcoma, Metastatic, Stomach,
Forestomach 1 (2%)
Acinar Cell, Adenoma 9 (18%) 5 (10%)
Acinar Cell, Adenoma, Multiple 3 (6%)
Acinar Cell, Carcinoma, Multiple 1 (2%)
Pharynx (1)
Squamous Cell Papilloma 1 (100%)
Stomach, Forestomach (50) (50)
Leiomyosarcoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Tongue (2)
Squamous Cell Carcinoma 1 (50%)
Squamous Cell Papilloma 1 (50%)
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NTP Experiment-Test: 05099-98 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 05/10/95
Route: GAVAGE Time: 11:56:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0 MG/KG
AD LIB RTD
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
Schwannoma Malignant 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (50)
Adenoma 1 (2%)
Adrenal Medulla (50) (50)
Pheochromocytoma Malignant 2 (4%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 12 (24%) 5 (10%)
Bilateral, Pheochromocytoma Benign 3 (6%) 3 (6%)
Islets, Pancreatic (50) (50)
Adenoma 2 (4%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (50) (50)
Ganglioneuroma 1 (2%)
Pars Distalis, Adenoma 14 (28%) 13 (26%)
Thyroid Gland (50) (49)
C-Cell, Adenoma 3 (6%) 4 (8%)
C-Cell, Carcinoma 2 (4%)
Follicular Cell, Adenoma 4 (8%)
Follicular Cell, Carcinoma 1 (2%)
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GENERAL BODY SYSTEM
Tissue NOS (1)
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GENITAL SYSTEM
Epididymis (50) (50)
Preputial Gland (50) (50)
Adenoma 1 (2%) 3 (6%)
Carcinoma 2 (4%)
Testes (50) (50)
Bilateral, Interstitial Cell, Adenoma 44 (88%) 38 (76%)
Interstitial Cell, Adenoma 1 (2%) 6 (12%)
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NTP Experiment-Test: 05099-98 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 05/10/95
Route: GAVAGE Time: 11:56:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0 MG/KG
AD LIB RTD
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Lymph Node (9) (11)
Lymph Node, Mandibular (50) (50)
Lymph Node, Mesenteric (50) (50)
Spleen (50) (50)
Leiomyosarcoma, Metastatic, Stomach,
Forestomach 1 (2%)
Thymus (47) (46)
Thymoma Benign 1 (2%)
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INTEGUMENTARY SYSTEM
Mammary Gland (48) (49)
Fibroadenoma 3 (6%) 2 (4%)
Skin (50) (50)
Basal Cell Adenoma 2 (4%) 1 (2%)
Keratoacanthoma 3 (6%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Trichoepithelioma 2 (4%)
Subcutaneous Tissue, Fibroma 2 (4%) 2 (4%)
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MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (2)
Fibrous Histiocytoma 1 (100%)
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NERVOUS SYSTEM
Brain (50) (50)
Astrocytoma Malignant 1 (2%)
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RESPIRATORY SYSTEM
Lung (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (4%)
Nose (50) (50)
Squamous Cell Carcinoma 1 (2%)
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NTP Experiment-Test: 05099-98 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 05/10/95
Route: GAVAGE Time: 11:56:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0 MG/KG
AD LIB RTD
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
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URINARY SYSTEM
Kidney (50) (50)
Renal Tubule, Carcinoma 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Leukemia Mononuclear 13 (26%) 10 (20%)
Mesothelioma Malignant 1 (2%) 3 (6%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05099-98 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 05/10/95
Route: GAVAGE Time: 11:56:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 0 MG/KG
AD LIB RTD
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 48
Total Primary Neoplasms 144 114
Total Animals with Benign Neoplasms 49 48
Total Benign Neoplasms 114 94
Total Animals with Malignant Neoplasms 23 17
Total Malignant Neoplasms 30 20
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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