TDMS Study 05099-07 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
SALICYLAZOSULFAPYRIDINE
NTP Experiment-Test: 05099-07 Report: PEIRPT09
Study Type: CHRONIC Date: 04/07/95
Route: GAVAGE Time: 15:23:08
RTD FEED CORE STUDY COMPARISON (MALES ONLY)
Facility: Southern Research Institute
Chemical CAS #: 599-79-1
Lock Date: 02/03/93
Cage Range: All
Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 007 337.5 MG/KG
Include 010 0 MG/KG FEED RTD
Page 1
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 5| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 0| 3| 0| 2| 8| 3| 2| 6| 8| 9| 3| 2| 0| 1| 3| 2| 4| 3| 2| 3| 3| 7| 2|
| 1| 4| 4| 1| 4| 9| 5| 1| 9| 5| 1| 6| 6| 8| 8| 8| 1| 9| 5| 2| 3| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
337.5 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Perforation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
Ulcer | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Subacute | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X|
Developmental Malformation | |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Subacute | 1 1 |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Lobules, Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Accessory Spleen | |
Fat, Necrosis | 2 3 2 3 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 1 1 3 3 1 1|
Acinar Cell, Cytoplasmic Alteration | 4 4 4 4 3 3 3 3 4 |
Acinar Cell, Hyperplasia, Focal | 2 2 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 2 |
Inflammation, Chronic | |
Mineralization | 3 |
Perforation | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 5| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 0| 3| 0| 2| 8| 3| 2| 6| 8| 9| 3| 2| 0| 1| 3| 2| 4| 3| 2| 3| 3| 7| 2|
| 1| 4| 4| 1| 4| 9| 5| 1| 9| 5| 1| 6| 6| 8| 8| 8| 1| 9| 5| 2| 3| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
337.5 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 2 3 2 |
Mucosa, Hyperplasia | 2 3 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Erosion | 3 1 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 2 1 1 2 2 3 3 2|
Foreign Body | |
Inflammation, Subacute | |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X |
Basophilic Focus | |
Degeneration, Fatty | 1 2 1 2 1 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 |
Hyperplasia, Focal | 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 1 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 2 3 1 1 2 3 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 |
Follicular Cell, Hyperplasia | |
Follicular Cell, Hypertrophy | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 5| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 0| 3| 0| 2| 8| 3| 2| 6| 8| 9| 3| 2| 0| 1| 3| 2| 4| 3| 2| 3| 3| 7| 2|
| 1| 4| 4| 1| 4| 9| 5| 1| 9| 5| 1| 6| 6| 8| 8| 8| 1| 9| 5| 2| 3| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
337.5 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X X X X X X X X X X X X X X X|
Hypospermia | X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 2 3 2 3 |
Hyperplasia | |
Inflammation, Chronic | 2 2 3 2|
Inflammation, Suppurative | 3 3 2 4 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 2 2 2 2 3|
Edema | 2 3 |
Hemorrhage | 3 2 |
Inflammation, Suppurative | 1 3 2 1 1 4 2 2 1 3 |
Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + M + + + + + + + + +|
Dilatation | 3 3 3 |
Hemorrhage | 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Hemorrhage | 3 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | 4 3 4 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + I + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hemorrhage | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 1 2 3 2 2 3 2 2 2 2 |
Hyperplasia, Reticulum Cell | 3 |
Pigmentation, Hemosiderin | 2 3 3 2 3 3 3 3 2 2 2 2 3 3 |
Lymphoid Follicle, Atrophy | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Cortex, Atrophy | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 5| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 0| 3| 0| 2| 8| 3| 2| 6| 8| 9| 3| 2| 0| 1| 3| 2| 4| 3| 2| 3| 3| 7| 2|
| 1| 4| 4| 1| 4| 9| 5| 1| 9| 5| 1| 6| 6| 8| 8| 8| 1| 9| 5| 2| 3| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
337.5 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 1 1 1 2|
Hyperplasia, Lobular | 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 2 |
Fibrosis | |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 2 |
Inflammation, Subacute | |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X|
Foreign Body | 1 1 |
Fungus | X X |
Mucosa, Hyperplasia | 2 3 2 2|
Mucosa, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 3 3 3 3 3 4 1 3 2 3 3 1 3 3 3 3 3|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 5| 6| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 0| 0| 3| 0| 2| 8| 3| 2| 6| 8| 9| 3| 2| 0| 1| 3| 2| 4| 3| 2| 3| 3| 7| 2|
| 1| 4| 4| 1| 4| 9| 5| 1| 9| 5| 1| 6| 6| 8| 8| 8| 1| 9| 5| 2| 3| 2| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
337.5 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hydronephrosis | 2 3 2 2 3 3 2 1 1 2 2 2 3 3|
Infarct | |
Inflammation, Suppurative | 1 |
Mineralization | 3 3 1 1 1 2 3 |
Nephropathy | 2 2 3 2 3 3 1 3 3 2 3 3 2 1 2 3 2 3 1 3 3 3 2 2 2|
Papilla, Fibrosis | 2 |
Papilla, Necrosis | 3 3 2 |
Renal Tubule, Dilatation | 3 3 3 3 2 3 2|
Renal Tubule, Pigmentation | 4 2 2|
Transitional Epithelium, Hyperplasia,| |
Atypical | 3 3|
Transitional Epithelium, Hyperplasia | 2 3 4 1 3 3 4 3 2 3 1 3 1 2 2 3 2 3 3 3 3 4|
Transitional Epithelium, Metaplasia | 2 |
__________________________________________________________________________|
Ureter | + + + + + +|
Concretion | 3 |
Dilatation | |
Inflammation, Subacute | |
Mucosa, Hyperplasia | 3 3 1 3 3|
__________________________________________________________________________|
Urethra | + + + |
Concretion | |
Inflammation, Subacute | |
Lumen, Concretion | 4 2 |
Mucosa, Hyperplasia | |
Mucosa, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 4 2 4 3 2 3 4 |
Congestion | 3 |
Dilatation | 4 4 3 4 |
Hemorrhage | 2 4 1 |
Inflammation, Subacute | 2 |
Mucosa, Hyperplasia | 2 3 3 3 4 2 3 4 2 2 3 3 3 2 2 3 2 4 3 1 3 3|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6| 4| 1| 6| 7| 7| 7| 7| 2| 6| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 8| 2| 2| 3| 5| 2| 3| 8| 7| 2| 5| 2| 0| 3| 2| 4| 5| 5| 2| 1| 3| 2| 3| |
| 2| 2| 4| 6| 9| 2| 8| 9| 5| 7| 3| 2| 9| 9| 5| 2| 9| 0| 3| 9| 9| 3| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
337.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Perforation | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + M + + + + + + + + + + + + + + + + + + + M +| 48 |
Inflammation, Subacute | | 1 2.0|
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + I| 49 |
Parasite Metazoan | X X | 5 |
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 | 1 3.0|
Inflammation, Subacute | | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 3.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X | 20 |
Clear Cell Focus | X X X X X X X X X | 16 |
Developmental Malformation | X | 1 |
Eosinophilic Focus | X X X X X X X X | 9 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Subacute | | 2 1.0|
Mixed Cell Focus | X X | 2 |
Bile Duct, Hyperplasia | 1 1 1 1 2 1 1| 21 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 2 2.5|
Lobules, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 12 |
Accessory Spleen | X | 1 |
Fat, Necrosis | 4 2 2 | 9 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 1 2 1 1 1 1| 19 1.4|
Acinar Cell, Cytoplasmic Alteration | 3 4 4 3 3 3 | 15 3.5|
Acinar Cell, Hyperplasia, Focal | 2 2 3 2 | 8 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6| 4| 1| 6| 7| 7| 7| 7| 2| 6| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 8| 2| 2| 3| 5| 2| 3| 8| 7| 2| 5| 2| 0| 3| 2| 4| 5| 5| 2| 1| 3| 2| 3| |
| 2| 2| 4| 6| 9| 2| 8| 9| 5| 7| 3| 2| 9| 9| 5| 2| 9| 0| 3| 9| 9| 3| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
337.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | 3 2 3 | 4 2.5|
Erosion | 3 | 2 2.5|
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | | 1 3.0|
Perforation | X | 1 |
Ulcer | 3 3 3 | 7 2.7|
Mucosa, Hyperplasia | 4 3 3 3 2 | 9 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Erosion | | 2 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | 4 3 4 3 | 5 3.4|
Inflammation, Chronic Active | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 1 2 3 1 2 3 2 2 2 3| 24 2.1|
Foreign Body | 3 | 1 3.0|
Inflammation, Subacute | 4 | 1 4.0|
Mineralization | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X X | 8 |
Basophilic Focus | X | 1 |
Degeneration, Fatty | 1 2 2 | 8 1.5|
Hematopoietic Cell Proliferation | 1| 2 1.5|
Hemorrhage | | 1 2.0|
Hyperplasia, Focal | 1 | 3 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + I + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 1 2 3 2 1 2 1| 14 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + + + + + M + + + + + + + + M + + +| 45 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Angiectasis | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6| 4| 1| 6| 7| 7| 7| 7| 2| 6| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 8| 2| 2| 3| 5| 2| 3| 8| 7| 2| 5| 2| 0| 3| 2| 4| 5| 5| 2| 1| 3| 2| 3| |
| 2| 2| 4| 6| 9| 2| 8| 9| 5| 7| 3| 2| 9| 9| 5| 2| 9| 0| 3| 9| 9| 3| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
337.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Cyst | X X X | 5 |
Pars Distalis, Hyperplasia, Focal | 1 3 2 2 3 1 | 12 2.0|
Pars Intermedia, Angiectasis | 3 | 1 3.0|
Pars Intermedia, Cyst | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X | 1 |
C-Cell, Hyperplasia | 1 2 1 1 1 1 2 1 | 11 1.2|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
Follicular Cell, Hypertrophy | 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | X X X X X X X X X X X X X X X| 31 |
Hypospermia | X X X X X X X X X X X X X X X X X X| 36 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 3 4 3 3 3 3 3 | 14 2.9|
Hyperplasia | 2 2 | 2 2.0|
Inflammation, Chronic | 2 2 2 1 2 | 9 2.0|
Inflammation, Suppurative | 1 2 2 1 2 2 3 2 2 1 3 | 17 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 2 3 2 2| 11 2.2|
Edema | | 2 2.5|
Hemorrhage | 3 | 3 2.7|
Inflammation, Suppurative | 2 4 1 3 3 3 2 2 3 2 3 | 21 2.3|
Epithelium, Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 | 4 3.0|
Hemorrhage | 4 | 2 3.5|
Inflammation, Suppurative | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
Seminiferous Tubule, Atrophy | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 2| 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6| 4| 1| 6| 7| 7| 7| 7| 2| 6| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 8| 2| 2| 3| 5| 2| 3| 8| 7| 2| 5| 2| 0| 3| 2| 4| 5| 5| 2| 1| 3| 2| 3| |
| 2| 2| 4| 6| 9| 2| 8| 9| 5| 7| 3| 2| 9| 9| 5| 2| 9| 0| 3| 9| 9| 3| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
337.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 10 |
Mediastinal, Hemorrhage | 3 3 | 4 2.8|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Pigmentation | 3 | 5 3.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 | 1 3.0|
Hemorrhage | 2 1 | 3 1.3|
Hyperplasia, Lymphoid | 2 3 3 2 2| 7 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 2 2 3 3 2 2 2 2 2 2 2 2| 23 2.1|
Hyperplasia, Reticulum Cell | | 1 3.0|
Pigmentation, Hemosiderin | 2 3 2 2 3 1 2 3 2 1 3 3 2 3 2 2| 30 2.4|
Lymphoid Follicle, Atrophy | 3 2 3 | 5 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Cortex, Atrophy | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + I + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Cystic | 3 2 2 3 2 | 10 1.9|
Hyperplasia, Lobular | 2 2 | 6 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 1.0|
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calvarium, Osteopetrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X | 4 |
Hydrocephalus | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6| 4| 1| 6| 7| 7| 7| 7| 2| 6| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 8| 2| 2| 3| 5| 2| 3| 8| 7| 2| 5| 2| 0| 3| 2| 4| 5| 5| 2| 1| 3| 2| 3| |
| 2| 2| 4| 6| 9| 2| 8| 9| 5| 7| 3| 2| 9| 9| 5| 2| 9| 0| 3| 9| 9| 3| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
337.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 2 3 2 | 4 2.5|
Edema | 2 3 2 | 4 2.3|
Fibrosis | 3 | 1 3.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 1 1 1 1 2 2 1 | 12 1.3|
Inflammation, Subacute | 3 3 2 | 3 2.7|
Metaplasia, Osseous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 3 2 | 6 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X X X X| 14 |
Foreign Body | | 2 1.0|
Fungus | | 2 |
Mucosa, Hyperplasia | 2 3 | 6 2.3|
Mucosa, Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Concretion | 3 3 3 3 1 3 3 2 2 2 3 3 2 2 3 2| 33 2.6|
Hemorrhage | | 1 3.0|
Hydronephrosis | 3 2 2 2 2 2 3 2 2 2 3 2 2 2| 28 2.2|
Infarct | 2 | 1 2.0|
Inflammation, Suppurative | 1 2 1 1 1 | 6 1.2|
Mineralization | 1 2 1 1 3 2 | 13 1.8|
Nephropathy | 2 3 2 2 3 2 3 3 4 2 1 4 3 4 3 3 2 3 3 2 3 3 3| 48 2.5|
Papilla, Fibrosis | | 1 2.0|
Papilla, Necrosis | 2 | 4 2.5|
Renal Tubule, Dilatation | 3 3 3 2 | 11 2.7|
Renal Tubule, Pigmentation | | 3 2.7|
Transitional Epithelium, Hyperplasia,| | |
Atypical | 3 | 3 3.0|
Transitional Epithelium, Hyperplasia | 3 2 3 3 3 2 3 3 3 2 2 3 3 2 3 3 2 2 3 2 3| 43 2.6|
Transitional Epithelium, Metaplasia | | 1 2.0|
__________________________________________________________________________|____________|
Ureter | + + M + + + + +| 13 |
Concretion | 3 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 6| 7| 6| 6| 4| 1| 6| 7| 7| 7| 7| 2| 6| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 8| 2| 2| 3| 5| 2| 3| 8| 7| 2| 5| 2| 0| 3| 2| 4| 5| 5| 2| 1| 3| 2| 3| |
| 2| 2| 4| 6| 9| 2| 8| 9| 5| 7| 3| 2| 9| 9| 5| 2| 9| 0| 3| 9| 9| 3| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
337.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Dilatation | 3 2 | 2 2.5|
Inflammation, Subacute | 2 | 1 2.0|
Mucosa, Hyperplasia | 1 3 3 1 2 2 3| 12 2.3|
__________________________________________________________________________|____________|
Urethra | + + | 5 |
Concretion | 3 | 1 3.0|
Inflammation, Subacute | 1 | 1 1.0|
Lumen, Concretion | | 2 3.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
Mucosa, Metaplasia, Squamous | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Concretion | 2 4 3| 10 3.1|
Congestion | | 1 3.0|
Dilatation | 4 3 3 | 7 3.6|
Hemorrhage | 3 | 4 2.5|
Inflammation, Subacute | 1 3 | 3 2.0|
Mucosa, Hyperplasia | 4 3 2 4 2 3 2 3 3 3 3 4 3 4 2 2 1 1 3| 41 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 2| 3| 8| 3| 2| 3| 2| 6| 2| 3| 3| 4| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3|
| 0| 1| 0| 9| 0| 7| 0| 6| 6| 6| 0| 0| 2| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X|
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 3 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Subacute | 1 |
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 2 1 2 2 2 1 2 3 1 2 3 3 2 3 2 3 3 1 1 2 1|
Centrilobular, Atrophy | 2 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
Accessory Spleen | X |
Fat, Necrosis | 4 3 3 3 4 4 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 2 1 2 |
Acinar Cell, Basophilic Focus | X X |
Acinar Cell, Cytoplasmic Alteration | 3 4 |
Acinar Cell, Hyperplasia, Focal | 2 3 1 2 3 2 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 3 |
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 2| 3| 8| 3| 2| 3| 2| 6| 2| 3| 3| 4| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3|
| 0| 1| 0| 9| 0| 7| 0| 6| 6| 6| 0| 0| 2| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 2 3 2 2 2 1 3 2 3 1 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X X X X X X X|
Degeneration, Fatty | 1 1 2 1 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal | 1 |
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 1 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 1 2 2 1 3 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 1 2 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | X X X X X X X X X X X X X X X X X|
Hypospermia | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 3 4 2 3 3 |
Hyperplasia | 2 |
Inflammation, Chronic | 2 2 2 3 2 2 2 3 |
Inflammation, Suppurative | 2 3 3 2 4 3 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Corpora Amylacea | 2 2 2 2 2 2 2 2 2 3 3 |
Inflammation, Suppurative | 2 2 2 1 1 1 2 1 2 4 2 2 1 3 2 1|
Epithelium, Hyperplasia | 1 2 1 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 2| 3| 8| 3| 2| 3| 2| 6| 2| 3| 3| 4| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3|
| 0| 1| 0| 9| 0| 7| 0| 6| 6| 6| 0| 0| 2| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Granuloma Sperm | |
Interstitial Cell, Hyperplasia | 1 2 2 |
Seminiferous Tubule, Atrophy | 3 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Iliac, Pigmentation | 3 |
Mediastinal, Hemorrhage | 3 3 1 3|
Mediastinal, Pigmentation | 2 3 2 3 3 3|
Pancreatic, Hemorrhage | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Ectasia | 3 2 3 4|
Hemorrhage | 3 1 |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | |
Pigmentation | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 |
Hemorrhage | 2 1 3 2 1 |
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 |
Hematopoietic Cell Proliferation | 1 2 4 |
Metaplasia | 3 |
Necrosis | |
Pigmentation, Hemosiderin | 2 3 3 3 3 2 2 3 2 3|
Lymphoid Follicle, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 4 2 3 3 1 3 3 2 |
Hyperplasia, Lobular | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Cyst Epithelial Inclusion | X X |
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 2| 3| 8| 3| 2| 3| 2| 6| 2| 3| 3| 4| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3|
| 0| 1| 0| 9| 0| 7| 0| 6| 6| 6| 0| 0| 2| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Compression | X X X X X |
Hydrocephalus | 2 3 3 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Edema | 2 |
Foreign Body | 3 |
Hemorrhage | 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 |
Inflammation, Subacute | 1 1 |
Inflammation, Suppurative | 1 |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | X X X X X X X|
Foreign Body | 2 2 4 1|
Fungus | X X |
Mucosa, Hyperplasia | 2 1 3 1 3|
Mucosa, Metaplasia, Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Suppurative | 1|
Mineralization | 1 1 1 2 1 |
Nephropathy | 1 1 1 2 1 1 2 2 1 2 1 1 1 1 2 1 1 1 1 2 1 1 2 1 2|
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | 2 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 7| 6| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 2| 3| 8| 3| 2| 3| 2| 6| 2| 3| 3| 4| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 3|
| 0| 1| 0| 9| 0| 7| 0| 6| 6| 6| 0| 0| 2| 0| 0| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
FEED RTD | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Ectasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 7| 0| 3| 3| 9| 0| 8| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 9| |
| 0| 8| 9| 1| 1| 7| 4| 4| 0| 8| 1| 1| 1| 9| 1| 0| 1| 1| 0| 6| 3| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Perforation | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 2 | 2 2.5|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X| 36 |
Clear Cell Focus | X X X X X X X X X X X | 21 |
Degeneration, Cystic | 1 | 2 1.0|
Eosinophilic Focus | X X X X X | 7 |
Hematopoietic Cell Proliferation | 1 | 2 2.0|
Hepatodiaphragmatic Nodule | X X | 3 |
Inflammation, Subacute | 1 | 2 1.0|
Mixed Cell Focus | X X X X X X X X | 11 |
Bile Duct, Hyperplasia | 2 3 4 3 2 1 2 2 1 2 2 1 1 1 2 4 2 1 2 | 40 2.0|
Centrilobular, Atrophy | 2 | 4 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 16 |
Accessory Spleen | | 1 |
Fat, Necrosis | 3 3 3 2 3 3 3 | 14 3.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 1 1 1 2 1 1 1 2| 17 1.4|
Acinar Cell, Basophilic Focus | X | 3 |
Acinar Cell, Cytoplasmic Alteration | | 2 3.5|
Acinar Cell, Hyperplasia, Focal | 2 3 2 1 4 3 3 3 4 | 17 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 | 1 2.0|
Mucosa, Hyperplasia | 3 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 7| 0| 3| 3| 9| 0| 8| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 9| |
| 0| 8| 9| 1| 1| 7| 4| 4| 0| 8| 1| 1| 1| 9| 1| 0| 1| 1| 0| 6| 3| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 3 3 2 1 2 2 2 2 2 1 2| 30 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X X X X X X| 13 |
Degeneration, Fatty | | 4 1.3|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Focal | 1 1 | 3 1.0|
Hypertrophy, Focal | 1| 2 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 1 1 1 1 1 | 14 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + M + + +| 48 |
Pars Distalis, Angiectasis | 2 2 | 4 2.3|
Pars Distalis, Cyst | X X X X X | 6 |
Pars Distalis, Hyperplasia, Focal | 2 1 3 2 1 2 2 1| 14 1.8|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | X X X | 3 |
C-Cell, Hyperplasia | 1 1 1 1 1 1 2 2 | 14 1.2|
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | X X X X X X X X X X X X X X X| 32 |
Hypospermia | X X X X X X X X X X X X X X X X X X| 33 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 3 2 3 2 3 | 12 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 7| 0| 3| 3| 9| 0| 8| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 9| |
| 0| 8| 9| 1| 1| 7| 4| 4| 0| 8| 1| 1| 1| 9| 1| 0| 1| 1| 0| 6| 3| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 3 2 2 2 3 2 3 2| 16 2.3|
Inflammation, Suppurative | 3 4 3 2 3 2| 14 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Corpora Amylacea | 2 3 2 2 2 2 2 2 2 2 2 | 22 2.1|
Inflammation, Suppurative | 1 3 2 3 3 1 2 2 1 3 1 | 27 1.9|
Epithelium, Hyperplasia | 1 1 2 | 8 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 2 3.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 3 | 1 3.0|
Interstitial Cell, Hyperplasia | 1 1 1 2 | 7 1.4|
Seminiferous Tubule, Atrophy | 4 | 4 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypercellularity | 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + +| 15 |
Iliac, Pigmentation | | 1 3.0|
Mediastinal, Hemorrhage | 3 2| 6 2.5|
Mediastinal, Pigmentation | 4 3| 8 2.9|
Pancreatic, Hemorrhage | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 3.0|
Ectasia | 2 2 2 | 7 2.6|
Hemorrhage | 1 1 | 4 1.5|
Hyperplasia, Lymphoid | 2 2 2 | 5 2.0|
Hyperplasia, Plasma Cell | 2| 1 2.0|
Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 | 2 3.5|
Hemorrhage | 1 | 6 1.7|
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 3 3.0|
Hematopoietic Cell Proliferation | 2 2 2 3 2 2 | 9 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 7| 0| 3| 3| 9| 0| 8| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 9| |
| 0| 8| 9| 1| 1| 7| 4| 4| 0| 8| 1| 1| 1| 9| 1| 0| 1| 1| 0| 6| 3| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Metaplasia | | 1 3.0|
Necrosis | 3 | 1 3.0|
Pigmentation, Hemosiderin | 2 3 2 1 2 2 2 2 2 2 | 20 2.3|
Lymphoid Follicle, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 3 4 3 2 2 1 | 16 2.5|
Hyperplasia, Lobular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 | 2 2.5|
Cyst Epithelial Inclusion | X X | 4 |
Hyperkeratosis | 2 | 2 2.5|
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calvarium, Osteopetrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Compression | X X | 7 |
Hydrocephalus | 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 2.5|
Edema | 2 | 2 2.0|
Foreign Body | 1 | 2 2.0|
Hemorrhage | 2 2 2 | 5 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 | 8 1.0|
Inflammation, Subacute | 2 | 3 1.3|
Inflammation, Suppurative | 2 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05099-07 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 04/07/95
Route: GAVAGE Time: 15:23:08
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 7| 0| 3| 3| 9| 0| 8| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 4| 0| 3| 3| 3| 9| |
| 0| 8| 9| 1| 1| 7| 4| 4| 0| 8| 1| 1| 1| 9| 1| 0| 1| 1| 0| 6| 3| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L |
FEED RTD | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 2 1 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Exudate | X X X X X X X X | 15 |
Foreign Body | 2 2 2 | 7 2.1|
Fungus | X | 3 |
Mucosa, Hyperplasia | 2 2 2 | 8 2.0|
Mucosa, Metaplasia, Squamous | 2 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + +| 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Inflammation, Suppurative | 1 1 | 3 1.0|
Mineralization | 1 | 6 1.2|
Nephropathy | 2 1 1 1 1 1 1 1 2 1 2 2 2 1 1 1 1 1 1 2 1 2 2 2 1| 50 1.3|
Renal Tubule, Dilatation | 2 | 1 2.0|
Renal Tubule, Pigmentation | 3 3 | 3 2.7|
Transitional Epithelium, Hyperplasia | 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Bulbourethral Gland, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
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---------- END OF REPORT ----------
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