TDMS Study 05121-08 Pathology Tables
NEOPLASMS BY INDIVIDUAL ANIMAL
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
NTP Experiment-Test: 05121-08 Report: PEIRPT04
Study Type: DIET_RES Date: 03/09/95
Route: GAVAGE Time: 14:30:08
RESTRICTED 36 MONTH
Facility: Battelle Columbus Laboratory
Chemical CAS #: 6533-68-2
Lock Date: 05/13/92
Cage Range: All
Reasons For Removal: 25018 Dosing Accident 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG 20%/36M
Include 004 0 MG/KG 20%/36M
Include 006 25 MG/KG20%/36M
Include 008 25 MG/KG20%/36M
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 0| 0| 0| 8| 0| 0| 9| 0| 0| 0| 5| 0| 9| 9| 8| 0| 8| 9| 0| 8| 0| 0| 9| 0| 8|
DAY ON TEST | 8| 8| 5| 5| 8| 8| 4| 8| 8| 8| 5| 8| 1| 2| 9| 8| 4| 2| 8| 6| 8| 0| 7| 8| 5|
| 7| 7| 0| 6| 7| 7| 6| 7| 7| 5| 5| 7| 1| 1| 8| 7| 6| 7| 7| 0| 7| 7| 4| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X X|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Mesentery | + |
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 0| 0| 0| 8| 0| 0| 9| 0| 0| 0| 5| 0| 9| 9| 8| 0| 8| 9| 0| 8| 0| 0| 9| 0| 8|
DAY ON TEST | 8| 8| 5| 5| 8| 8| 4| 8| 8| 8| 5| 8| 1| 2| 9| 8| 4| 2| 8| 6| 8| 0| 7| 8| 5|
| 7| 7| 0| 6| 7| 7| 6| 7| 7| 5| 5| 7| 1| 1| 8| 7| 6| 7| 7| 0| 7| 7| 4| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + M + + + + + + + +|
Pars Distalis, Adenoma | X X |
Pars Intermedia, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Benign | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Multiple | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant Mixed | X X |
Axillary, Sarcoma, Metastatic, Skin | |
Pancreatic, Sarcoma, Metastatic, Skin| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + M + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X|
Mast Cell Tumor NOS | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 0| 0| 0| 8| 0| 0| 9| 0| 0| 0| 5| 0| 9| 9| 8| 0| 8| 9| 0| 8| 0| 0| 9| 0| 8|
DAY ON TEST | 8| 8| 5| 5| 8| 8| 4| 8| 8| 8| 5| 8| 1| 2| 9| 8| 4| 2| 8| 6| 8| 0| 7| 8| 5|
| 7| 7| 0| 6| 7| 7| 6| 7| 7| 5| 5| 7| 1| 1| 8| 7| 6| 7| 7| 0| 7| 7| 4| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + M + + + M + + + M M + + + M + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant Mixed | X X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X X |
Lymphoma Malignant Mixed | X X X X|
__________________________________________________________________________|
Thymus | + + + M M + + + + + M + M + + + + M + + + + M M +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 0| 0| 0| 8| 0| 0| 9| 0| 0| 0| 5| 0| 9| 9| 8| 0| 8| 9| 0| 8| 0| 0| 9| 0| 8|
DAY ON TEST | 8| 8| 5| 5| 8| 8| 4| 8| 8| 8| 5| 8| 1| 2| 9| 8| 4| 2| 8| 6| 8| 0| 7| 8| 5|
| 7| 7| 0| 6| 7| 7| 6| 7| 7| 5| 5| 7| 1| 1| 8| 7| 6| 7| 7| 0| 7| 7| 4| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
Mediastinum, Lymphoma Malignant Mixed| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + M + M M M + + M + + M M + M M + M M + M M M|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Lymphoma Malignant Lymphocytic | X X X X X |
Lymphoma Malignant Mixed | X X X X|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 9| 0| 6| 8| 5| 0| 0| 7| 0| 7| 9| 9| 0| 6| 9| 5| 7| 0| 0| 0| 0| 9| 8| |
DAY ON TEST | 8| 8| 6| 2| 7| 6| 5| 8| 8| 9| 8| 7| 0| 2| 8| 1| 0| 3| 3| 5| 8| 8| 8| 3| 7| |
| 7| 7| 7| 0| 3| 6| 5| 7| 7| 6| 7| 1| 1| 8| 7| 1| 1| 7| 7| 0| 7| 7| 7| 8| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Mixed | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X | 3 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X X X | 11 |
Hepatocellular Adenoma, Multiple | X | 1 |
Histiocytic Sarcoma | X X | 4 |
Lymphoma Malignant Lymphocytic | | 4 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Mesentery | + + + + + | 6 |
Hemangiosarcoma | X | 1 |
Histiocytic Sarcoma | X X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Sarcoma, Metastatic, Skin | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 9| 0| 6| 8| 5| 0| 0| 7| 0| 7| 9| 9| 0| 6| 9| 5| 7| 0| 0| 0| 0| 9| 8| |
DAY ON TEST | 8| 8| 6| 2| 7| 6| 5| 8| 8| 9| 8| 7| 0| 2| 8| 1| 0| 3| 3| 5| 8| 8| 8| 3| 7| |
| 7| 7| 7| 0| 3| 6| 5| 7| 7| 6| 7| 1| 1| 8| 7| 1| 1| 7| 7| 0| 7| 7| 7| 8| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | | 1 |
Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + M + + + + + + + + + + + + + + + M + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + M M + + + + + + + + M + M M + + + M + + + + + +| 42 |
Pars Distalis, Adenoma | X | 3 |
Pars Intermedia, Adenoma | X | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cystadenoma | | 1 |
Granulosa Cell Tumor Benign | X | 1 |
Histiocytic Sarcoma | X X | 3 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X X | 4 |
Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 2 |
Hemangiosarcoma, Multiple | X | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 13 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 9| 0| 6| 8| 5| 0| 0| 7| 0| 7| 9| 9| 0| 6| 9| 5| 7| 0| 0| 0| 0| 9| 8| |
DAY ON TEST | 8| 8| 6| 2| 7| 6| 5| 8| 8| 9| 8| 7| 0| 2| 8| 1| 0| 3| 3| 5| 8| 8| 8| 3| 7| |
| 7| 7| 7| 0| 3| 6| 5| 7| 7| 6| 7| 1| 1| 8| 7| 1| 1| 7| 7| 0| 7| 7| 7| 8| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Lymphocytic | | 4 |
Lymphoma Malignant Mixed | X X | 4 |
Axillary, Sarcoma, Metastatic, Skin | X | 1 |
Pancreatic, Sarcoma, Metastatic, Skin| X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + M M + + + + + + + + + + + +| 45 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X X | 4 |
Mast Cell Tumor NOS | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| 43 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | X X X X X | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 12 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 4 |
Lymphoma Malignant Mixed | X X X X | 6 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 4 |
Lymphoma Malignant Mixed | X X X X X | 9 |
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + M M + + + + + + + + + + + M M +| 37 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 9| 0| 6| 8| 5| 0| 0| 7| 0| 7| 9| 9| 0| 6| 9| 5| 7| 0| 0| 0| 0| 9| 8| |
DAY ON TEST | 8| 8| 6| 2| 7| 6| 5| 8| 8| 9| 8| 7| 0| 2| 8| 1| 0| 3| 3| 5| 8| 8| 8| 3| 7| |
| 7| 7| 7| 0| 3| 6| 5| 7| 7| 6| 7| 1| 1| 8| 7| 1| 1| 7| 7| 0| 7| 7| 7| 8| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Malignant | X| 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | X | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X | 2 |
Mediastinum, Lymphoma Malignant Mixed| X X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | M M + M M + M + M M + + M + M M M + M M + + M + +| 22 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X X | 5 |
Lymphoma Malignant Lymphocytic | | 5 |
Lymphoma Malignant Mixed | X X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 6| 0| 0| 0| 0| 8| 0| 9| 0| 0| 7| 0| 9| 0| 0| 0| 8| 8| 0| 0| 0| 0| 9| 5| 7|
DAY ON TEST | 7| 8| 8| 0| 8| 3| 5| 6| 8| 6| 3| 8| 8| 1| 8| 8| 0| 4| 8| 8| 8| 8| 7| 6| 9|
| 9| 7| 7| 7| 7| 0| 6| 1| 7| 9| 7| 7| 0| 6| 7| 7| 3| 8| 7| 7| 7| 7| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X|
__________________________________________________________________________|
Mesentery | + + + |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X|
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Tooth | + |
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 6| 0| 0| 0| 0| 8| 0| 9| 0| 0| 7| 0| 9| 0| 0| 0| 8| 8| 0| 0| 0| 0| 9| 5| 7|
DAY ON TEST | 7| 8| 8| 0| 8| 3| 5| 6| 8| 6| 3| 8| 8| 1| 8| 8| 0| 4| 8| 8| 8| 8| 7| 6| 9|
| 9| 7| 7| 7| 7| 0| 6| 1| 7| 9| 7| 7| 0| 6| 7| 7| 3| 8| 7| 7| 7| 7| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Pars Distalis, Adenoma | X |
Pars Intermedia, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Bilateral, Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Adenoma | |
Adenoma, Tubular | |
Cystadenoma | X X |
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X|
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X|
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 6| 0| 0| 0| 0| 8| 0| 9| 0| 0| 7| 0| 9| 0| 0| 0| 8| 8| 0| 0| 0| 0| 9| 5| 7|
DAY ON TEST | 7| 8| 8| 0| 8| 3| 5| 6| 8| 6| 3| 8| 8| 1| 8| 8| 0| 4| 8| 8| 8| 8| 7| 6| 9|
| 9| 7| 7| 7| 7| 0| 6| 1| 7| 9| 7| 7| 0| 6| 7| 7| 3| 8| 7| 7| 7| 7| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + +|
Lymphoma Malignant Mixed | X X X|
Axillary, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Bronchial | + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + M|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X|
__________________________________________________________________________|
Thymus | + + + M M + M + + + M + + + + + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Sarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 6| 0| 0| 0| 0| 8| 0| 9| 0| 0| 7| 0| 9| 0| 0| 0| 8| 8| 0| 0| 0| 0| 9| 5| 7|
DAY ON TEST | 7| 8| 8| 0| 8| 3| 5| 6| 8| 6| 3| 8| 8| 1| 8| 8| 0| 4| 8| 8| 8| 8| 7| 6| 9|
| 9| 7| 7| 7| 7| 0| 6| 1| 7| 9| 7| 7| 0| 6| 7| 7| 3| 8| 7| 7| 7| 7| 2| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | M + M + M M M + M M M + + + M + M M + M M M + M +|
Adenoma | X |
Bilateral, Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X|
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 8| 0| 9| 9| 8| 7| 0| 0| 8| 0| 8| 0| 0| 8| 0| 9| 9| 9| 6| 7| |
DAY ON TEST | 4| 5| 8| 8| 8| 5| 4| 9| 8| 4| 0| 8| 8| 4| 8| 1| 8| 8| 1| 1| 7| 1| 5| 9| 3| |
| 5| 6| 7| 7| 7| 9| 5| 5| 7| 6| 3| 7| 7| 8| 7| 5| 7| 7| 4| 3| 4| 8| 2| 9| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
25 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | X X X | 4 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X X | 4 |
Hepatocellular Adenoma | X X X X | 7 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | X | 5 |
Lymphoma Malignant Lymphocytic | X X X | 4 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
Sarcoma, Metastatic, Skin | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X | 2 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
Histiocytic Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 8| 0| 9| 9| 8| 7| 0| 0| 8| 0| 8| 0| 0| 8| 0| 9| 9| 9| 6| 7| |
DAY ON TEST | 4| 5| 8| 8| 8| 5| 4| 9| 8| 4| 0| 8| 8| 4| 8| 1| 8| 8| 1| 1| 7| 1| 5| 9| 3| |
| 5| 6| 7| 7| 7| 9| 5| 5| 7| 6| 3| 7| 7| 8| 7| 5| 7| 7| 4| 3| 4| 8| 2| 9| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
25 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + + + + + + M + + + + + M M + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
Pars Distalis, Adenoma | X | 2 |
Pars Intermedia, Adenoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Bilateral, Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + M M + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 1 |
Adenoma, Tubular | X | 1 |
Cystadenoma | | 2 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X X | 4 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Histiocytic Sarcoma | | 3 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 8| 0| 9| 9| 8| 7| 0| 0| 8| 0| 8| 0| 0| 8| 0| 9| 9| 9| 6| 7| |
DAY ON TEST | 4| 5| 8| 8| 8| 5| 4| 9| 8| 4| 0| 8| 8| 4| 8| 1| 8| 8| 1| 1| 7| 1| 5| 9| 3| |
| 5| 6| 7| 7| 7| 9| 5| 5| 7| 6| 3| 7| 7| 8| 7| 5| 7| 7| 4| 3| 4| 8| 2| 9| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
25 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Polyp Stromal | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 8 |
Lymphoma Malignant Mixed | X X | 5 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Histiocytic Sarcoma | | 3 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X X X X X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + | 11 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X X X X | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 3 |
Lymphoma Malignant Lymphocytic | X X X | 3 |
Lymphoma Malignant Mixed | X X X | 6 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + M + + + + M + + + + + + + + + + + +| 42 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 8| 0| 9| 9| 8| 7| 0| 0| 8| 0| 8| 0| 0| 8| 0| 9| 9| 9| 6| 7| |
DAY ON TEST | 4| 5| 8| 8| 8| 5| 4| 9| 8| 4| 0| 8| 8| 4| 8| 1| 8| 8| 1| 1| 7| 1| 5| 9| 3| |
| 5| 6| 7| 7| 7| 9| 5| 5| 7| 6| 3| 7| 7| 8| 7| 5| 7| 7| 4| 3| 4| 8| 2| 9| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
25 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Sarcoma | X X X| 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 4 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X X | 3 |
Lymphoma Malignant Mixed | X X | 4 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + M M M + + + + + M + + + M M + M + + + + M M M +| 25 |
Adenoma | X | 2 |
Bilateral, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 8| 0| 9| 9| 8| 7| 0| 0| 8| 0| 8| 0| 0| 8| 0| 9| 9| 9| 6| 7| |
DAY ON TEST | 4| 5| 8| 8| 8| 5| 4| 9| 8| 4| 0| 8| 8| 4| 8| 1| 8| 8| 1| 1| 7| 1| 5| 9| 3| |
| 5| 6| 7| 7| 7| 9| 5| 5| 7| 6| 3| 7| 7| 8| 7| 5| 7| 7| 4| 3| 4| 8| 2| 9| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
25 MG/KG | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X X | 5 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 5 |
Lymphoma Malignant Lymphocytic | X X X | 4 |
Lymphoma Malignant Mixed | X X X X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 0| 0| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 1| 0| 0| 9|
DAY ON TEST | 8| 0| 7| 8| 6| 8| 8| 1| 8| 8| 6| 8| 4| 8| 2| 8| 8| 6| 8| 8| 8| 0| 8| 8| 4|
| 6| 2| 2| 6| 2| 6| 6| 6| 6| 6| 5| 6| 5| 6| 0| 6| 6| 3| 6| 6| 6| 8| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 0| 0| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 1| 0| 0| 9|
DAY ON TEST | 8| 0| 7| 8| 6| 8| 8| 1| 8| 8| 6| 8| 4| 8| 2| 8| 8| 6| 8| 8| 8| 0| 8| 8| 4|
| 6| 2| 2| 6| 2| 6| 6| 6| 6| 6| 5| 6| 5| 6| 0| 6| 6| 3| 6| 6| 6| 8| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + M + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | |
Histiocytic Sarcoma | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node | + + |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + |
Carcinoma, Metastatic, Lung | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 0| 0| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 1| 0| 0| 9|
DAY ON TEST | 8| 0| 7| 8| 6| 8| 8| 1| 8| 8| 6| 8| 4| 8| 2| 8| 8| 6| 8| 8| 8| 0| 8| 8| 4|
| 6| 2| 2| 6| 2| 6| 6| 6| 6| 6| 5| 6| 5| 6| 0| 6| 6| 3| 6| 6| 6| 8| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + M M + + + + + + M + + M + M M M + M M + + + + M|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + M + + + M + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X X X X|
Carcinoma, Metastatic, Harderian | |
Gland | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | X X |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 0| 0| 9| 0| 7| 0| 0| 0| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 1| 0| 0| 9|
DAY ON TEST | 8| 0| 7| 8| 6| 8| 8| 1| 8| 8| 6| 8| 4| 8| 2| 8| 8| 6| 8| 8| 8| 0| 8| 8| 4|
| 6| 2| 2| 6| 2| 6| 6| 6| 6| 6| 5| 6| 5| 6| 0| 6| 6| 3| 6| 6| 6| 8| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + M M M M M M + + M + M M M M M M M + + + M + M M|
Adenoma | |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 8| 0| 7| 8| 0| 0| 9| 9| 0| 7| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
DAY ON TEST | 5| 8| 9| 9| 8| 8| 8| 3| 1| 8| 5| 7| 8| 8| 6| 8| 8| 8| 1| 2| 8| 8| 8| 8| 8| |
| 9| 6| 9| 8| 6| 6| 7| 6| 9| 4| 0| 4| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 2 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X X X X X | 7 |
Hepatocellular Adenoma | X X X | 7 |
Histiocytic Sarcoma | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | X| 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Lung | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 8| 0| 7| 8| 0| 0| 9| 9| 0| 7| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
DAY ON TEST | 5| 8| 9| 9| 8| 8| 8| 3| 1| 8| 5| 7| 8| 8| 6| 8| 8| 8| 1| 2| 8| 8| 8| 8| 8| |
| 9| 6| 9| 8| 6| 6| 7| 6| 9| 4| 0| 4| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma, Metastatic, Spleen | X | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 8| 0| 7| 8| 0| 0| 9| 9| 0| 7| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
DAY ON TEST | 5| 8| 9| 9| 8| 8| 8| 3| 1| 8| 5| 7| 8| 8| 6| 8| 8| 8| 1| 2| 8| 8| 8| 8| 8| |
| 9| 6| 9| 8| 6| 6| 7| 6| 9| 4| 0| 4| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 7 |
Carcinoma, Metastatic, Lung | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | | 1 |
Hemangiosarcoma | X | 2 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M M M + + + M + + M M + + + + +| 34 |
Lymphoma Malignant Lymphocytic | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 8| 0| 7| 8| 0| 0| 9| 9| 0| 7| 0| 9| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| |
DAY ON TEST | 5| 8| 9| 9| 8| 8| 8| 3| 1| 8| 5| 7| 8| 8| 6| 8| 8| 8| 1| 2| 8| 8| 8| 8| 8| |
| 9| 6| 9| 8| 6| 6| 7| 6| 9| 4| 0| 4| 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
0 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X | 7 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 3 |
Alveolar/Bronchiolar Carcinoma | X X X | 7 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Lymphoma Malignant Lymphocytic | | 2 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + M + M + + + + M + + M M M + + M + M + M +| 24 |
Adenoma | X X | 2 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Lung | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X X | 3 |
Lymphoma Malignant Lymphocytic | X X X | 5 |
Lymphoma Malignant Mixed | X | 5 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 0| 0| 0| 2| 0| 0| 9| 7| 0| 0| 0| 0| 0| 0| 9| 0| 9| 8| 0| 0| 0| 0| 0| 0| 0|
DAY ON TEST | 8| 3| 8| 1| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 3| 8| 3| 1| 8| 8| 8| 8| 8| 8| 8|
| 6| 6| 6| 4| 6| 6| 3| 4| 6| 6| 6| 6| 6| 6| 3| 6| 1| 9| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
25 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Stomach, | |
Glandular | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 0| 0| 0| 2| 0| 0| 9| 7| 0| 0| 0| 0| 0| 0| 9| 0| 9| 8| 0| 0| 0| 0| 0| 0| 0|
DAY ON TEST | 8| 3| 8| 1| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 3| 8| 3| 1| 8| 8| 8| 8| 8| 8| 8|
| 6| 6| 6| 4| 6| 6| 3| 4| 6| 6| 6| 6| 6| 6| 3| 6| 1| 9| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
25 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + M + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M M + + + + + + + M + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Pancreatic, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M M + + + M + + + + +|
Carcinoma, Metastatic, Stomach, | |
Glandular | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 0| 0| 0| 2| 0| 0| 9| 7| 0| 0| 0| 0| 0| 0| 9| 0| 9| 8| 0| 0| 0| 0| 0| 0| 0|
DAY ON TEST | 8| 3| 8| 1| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 3| 8| 3| 1| 8| 8| 8| 8| 8| 8| 8|
| 6| 6| 6| 4| 6| 6| 3| 4| 6| 6| 6| 6| 6| 6| 3| 6| 1| 9| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
25 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + M M + + M M + + + M + + M + + + + + + + + M +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X|
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + M M M + M M M + M + + M + + M M + + M + M + M|
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
_____________________________________________________________________________________________________________________
| 0| 0| 0| 2| 0| 0| 9| 7| 0| 0| 0| 0| 0| 0| 9| 0| 9| 8| 0| 0| 0| 0| 0| 0| 0|
DAY ON TEST | 8| 3| 8| 1| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 3| 8| 3| 1| 8| 8| 8| 8| 8| 8| 8|
| 6| 6| 6| 4| 6| 6| 3| 4| 6| 6| 6| 6| 6| 6| 3| 6| 1| 9| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
25 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
20%/36M | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 8| 9| 9| 0| 0| 0| 9| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 0| 8| 0| 0| |
DAY ON TEST | 8| 8| 8| 8| 9| 2| 6| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| |
| 6| 6| 6| 6| 8| 4| 4| 6| 6| 6| 7| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 2| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
25 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Carcinoma | X | 1 |
Lymphoma Malignant Mixed | X X X X | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Stomach, | | |
Glandular | X| 1 |
Hepatocellular Carcinoma | X | 4 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma | X X | 7 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X| 1 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 7 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 8| 9| 9| 0| 0| 0| 9| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 0| 8| 0| 0| |
DAY ON TEST | 8| 8| 8| 8| 9| 2| 6| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| |
| 6| 6| 6| 6| 8| 4| 4| 6| 6| 6| 7| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 2| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
25 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Adenoma | X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 3 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X | 1 |
Pancreatic, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + M + +| 47 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 8| 9| 9| 0| 0| 0| 9| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 0| 8| 0| 0| |
DAY ON TEST | 8| 8| 8| 8| 9| 2| 6| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| |
| 6| 6| 6| 6| 8| 4| 4| 6| 6| 6| 7| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 2| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
25 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| 46 |
Carcinoma, Metastatic, Stomach, | | |
Glandular | X| 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + | 3 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X X | 3 |
__________________________________________________________________________|____________|
Thymus | + M M + + M M + + + + + + + + + M + + + + + + + +| 38 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X X | 9 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 2 |
Alveolar/Bronchiolar Carcinoma | X X X X X | 7 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05121-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: DIET_RES SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/09/95
Route: GAVAGE Time: 14:30:08
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 8| 9| 9| 0| 0| 0| 9| 0| 0| 0| 0| 8| 0| 0| 0| 0| 0| 0| 8| 0| 0| |
DAY ON TEST | 8| 8| 8| 8| 9| 2| 6| 8| 8| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| |
| 6| 6| 6| 6| 8| 4| 4| 6| 6| 6| 7| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 2| 6| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
25 MG/KG | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L |
20%/36M | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Harderian Gland | M + M + M M + M M M M + + + M M M + + M + + M + M| 23 |
Adenoma | X | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
Renal Tubule, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X | 4 |
Lymphoma Malignant Mixed | X X X X X X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
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---------- END OF REPORT ----------
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