TDMS Study 05121-99 Pathology Tables
NEOPLASMS BY INDIVIDUAL ANIMAL
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
NTP Experiment-Test: 05121-99 Report: PEIRPT04
Study Type: CHRONIC Date: 03/15/95
Route: GAVAGE Time: 17:08:10
05121/07 - 05121/08 COMPARISON
Facility: BATTELLE COLUMBUS LABORATORY
Chemical CAS #: 6533-68-2
Lock Date: 06/01/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25018 Dosing Accident
25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 MG/KG
Include 002 0 MG/KG
Include 003 RTD 0 MG/KG
Include 005 RTD 0 MG/KG
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 2| 1| 2| 2| 1| 3| 2| 1| 2| 2| 2| 3| 1| 3| 1| 2| 2| 0| 9| 0| 2|
| 9| 0| 0| 0| 8| 2| 8| 8| 0| 0| 8| 7| 8| 8| 8| 0| 1| 0| 1| 8| 8| 4| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 4| 5| 7| 9| 2| 4| 5| 6| 7| 8| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + M + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Multiple | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X X |
Hepatocholangiocarcinoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
Bile Duct, Carcinoma | X |
__________________________________________________________________________|
Mesentery | + + + + |
Carcinoma, Metastatic, Liver | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 2| 1| 2| 2| 1| 3| 2| 1| 2| 2| 2| 3| 1| 3| 1| 2| 2| 0| 9| 0| 2|
| 9| 0| 0| 0| 8| 2| 8| 8| 0| 0| 8| 7| 8| 8| 8| 0| 1| 0| 1| 8| 8| 4| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 4| 5| 7| 9| 2| 4| 5| 6| 7| 8| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X |
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Hemangiosarcoma | |
Hemangiosarcoma, Metastatic, Ovary | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Polyp Stromal | X |
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + + + |
Bronchial, Carcinoma, Metastatic, | |
Liver | X |
Bronchial, Hepatocholangiocarcinoma, | |
Metastatic, Liver | |
Bronchial, Lymphoma Malignant Mixed | X |
Inguinal, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant | |
Lymphocytic | |
Lumbar, Lymphoma Malignant Mixed | X |
Mediastinal, Carcinoma, Metastatic, | |
Liver | X |
Mediastinal, | |
Hepatocholangiocarcinoma, | |
Metastatic, Liver | |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 2| 1| 2| 2| 1| 3| 2| 1| 2| 2| 2| 3| 1| 3| 1| 2| 2| 0| 9| 0| 2|
| 9| 0| 0| 0| 8| 2| 8| 8| 0| 0| 8| 7| 8| 8| 8| 0| 1| 0| 1| 8| 8| 4| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 4| 5| 7| 9| 2| 4| 5| 6| 7| 8| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphocytic | |
Mediastinal, Lymphoma Malignant Mixed| X X |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + M + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Skeletal Muscle | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Harderian | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7|
DAY ON TEST | 7| 3| 3| 3| 2| 1| 2| 2| 1| 3| 2| 1| 2| 2| 2| 3| 1| 3| 1| 2| 2| 0| 9| 0| 2|
| 9| 0| 0| 0| 8| 2| 8| 8| 0| 0| 8| 7| 8| 8| 8| 0| 1| 0| 1| 8| 8| 4| 4| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 4| 5| 7| 9| 2| 4| 5| 6| 7| 8| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Gland | X |
Carcinoma, Metastatic, Liver | X |
Hemangiosarcoma, Metastatic, Ovary | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | M + M + M M + M + + M M M + M M M M + M M M + + M|
Adenoma | X |
Carcinoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 5| 7| 6| 6| 7| 7| 0| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 2| 2| 7| 3| 6| 2| 8| 0| 1| 1| 2| 2| 0| 3| 2| 9| 2| 3| 3| 2|
| 6| 0| 0| 0| 0| 8| 6| 3| 0| 1| 8| 1| 7| 1| 8| 6| 8| 7| 0| 8| 2| 8| 0| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
0 MG/KG | 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 8| 0| 1| 2| 3| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X X |
Hepatocholangiocarcinoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Bile Duct, Carcinoma | |
__________________________________________________________________________|
Mesentery | + + + |
Carcinoma, Metastatic, Liver | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 5| 7| 6| 6| 7| 7| 0| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 2| 2| 7| 3| 6| 2| 8| 0| 1| 1| 2| 2| 0| 3| 2| 9| 2| 3| 3| 2|
| 6| 0| 0| 0| 0| 8| 6| 3| 0| 1| 8| 1| 7| 1| 8| 6| 8| 7| 0| 8| 2| 8| 0| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
0 MG/KG | 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 8| 0| 1| 2| 3| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M M + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Hemangiosarcoma | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Hemangiosarcoma | X |
Hemangiosarcoma, Metastatic, Ovary | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
Polyp Stromal | |
Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node | + + + |
Bronchial, Carcinoma, Metastatic, | |
Liver | |
Bronchial, Hepatocholangiocarcinoma, | |
Metastatic, Liver | X |
Bronchial, Lymphoma Malignant Mixed | |
Inguinal, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant | |
Lymphocytic | X |
Lumbar, Lymphoma Malignant Mixed | |
Mediastinal, Carcinoma, Metastatic, | |
Liver | |
Mediastinal, | |
Hepatocholangiocarcinoma, | |
Metastatic, Liver | X |
Mediastinal, Histiocytic Sarcoma | X |
Mediastinal, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 5| 7| 6| 6| 7| 7| 0| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 2| 2| 7| 3| 6| 2| 8| 0| 1| 1| 2| 2| 0| 3| 2| 9| 2| 3| 3| 2|
| 6| 0| 0| 0| 0| 8| 6| 3| 0| 1| 8| 1| 7| 1| 8| 6| 8| 7| 0| 8| 2| 8| 0| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
0 MG/KG | 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 8| 0| 1| 2| 3| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphocytic | X |
Mediastinal, Lymphoma Malignant Mixed| |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Harderian | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 3| 7| 6| 7| 5| 7| 6| 6| 7| 7| 0| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 3| 3| 3| 2| 2| 7| 3| 6| 2| 8| 0| 1| 1| 2| 2| 0| 3| 2| 9| 2| 3| 3| 2|
| 6| 0| 0| 0| 0| 8| 6| 3| 0| 1| 8| 1| 7| 1| 8| 6| 8| 7| 0| 8| 2| 8| 0| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
0 MG/KG | 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 8| 0| 1| 2| 3| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Gland | |
Carcinoma, Metastatic, Liver | |
Hemangiosarcoma, Metastatic, Ovary | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + M M M + M M M M M + M + M M + M + M + + M M M M|
Adenoma | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0 MG/KG | 1| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
__________________________________________________________________________|____________|
Gallbladder | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 51 |
Carcinoma | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 50 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Hemangiosarcoma, Multiple | | 1 |
Hepatocellular Carcinoma | X | 7 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | | 10 |
Hepatocellular Adenoma, Multiple | | 5 |
Hepatocholangiocarcinoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
Bile Duct, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
Carcinoma, Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Carcinoma, Metastatic, Liver | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 51 |
__________________________________________________________________________|____________|
Heart | + | 51 |
Carcinoma, Metastatic, Liver | | 1 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0 MG/KG | 1| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Pheochromocytoma Malignant | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 50 |
Pars Distalis, Adenoma | | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Follicular Cell, Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 48 |
__________________________________________________________________________|____________|
Ovary | + | 51 |
Cystadenoma | | 3 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Uterus | + | 51 |
Adenoma | | 1 |
Hemangiosarcoma | | 1 |
Hemangiosarcoma, Metastatic, Ovary | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
Polyp Stromal | | 1 |
Sarcoma Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 6 |
Bronchial, Carcinoma, Metastatic, | | |
Liver | | 1 |
Bronchial, Hepatocholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
Bronchial, Lymphoma Malignant Mixed | | 1 |
Inguinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0 MG/KG | 1| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Lumbar, Lymphoma Malignant Mixed | | 1 |
Mediastinal, Carcinoma, Metastatic, | | |
Liver | | 1 |
Mediastinal, | | |
Hepatocholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
Mediastinal, Histiocytic Sarcoma | | 1 |
Mediastinal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Mediastinal, Lymphoma Malignant Mixed| | 2 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 50 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 50 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 3 |
__________________________________________________________________________|____________|
Spleen | + | 51 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 5 |
__________________________________________________________________________|____________|
Thymus | + | 48 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
__________________________________________________________________________|____________|
Skin | + | 51 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
Hepatocholangiocarcinoma, Metastatic,| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0 MG/KG | 1| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Alveolar/Bronchiolar Adenoma | | 3 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Carcinoma, Metastatic, Liver | | 1 |
Hemangiosarcoma, Metastatic, Ovary | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + | 51 |
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | M | 17 |
Adenoma | | 1 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Carcinoma, Metastatic, Liver | | 1 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0 MG/KG | 1| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 51 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 9|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
RTD | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 8| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + M + M + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Histiocytic Sarcoma | X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | +|
Histiocytic Sarcoma | X|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 9|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
RTD | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 8| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + M + + M + M + + M + +|
Histiocytic Sarcoma | X|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | +|
Histiocytic Sarcoma | X|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + M|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Histiocytic Sarcoma | X|
Lymphoma Malignant Mixed | X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 9|
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
RTD | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 8| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + M + M M M + M M + + M M M M + M M + + M + + + M|
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
RTD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| L |
0 MG/KG | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Adenoma | X X | 3 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + M + + + + + + + M + + M +| 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + M + M + + +| 46 |
Pars Intermedia, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
RTD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| L |
0 MG/KG | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +| 44 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thymus | + + M M M + + + + + + + + + + + + + + + + + + + +| 45 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 3 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
RTD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| L |
0 MG/KG | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 2| 3| 4| 5| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant Mixed | | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + M M M M M + M + M + M + M + M M M + + +| 24 |
Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 2| 2| 2| 2| 2| 2| 4| 2| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|
| 7| 9| 6| 6| 9| 7| 7| 7| 0| 9| 4| 4| 6| 5| 7| 7| 7| 9| 9| 9| 7| 7| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 2| 3| 5| 6| 7| 9| 0| 1| 4| 5| 6| 9| 0| 2| 3| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X|
Histiocytic Sarcoma | |
Ito Cell Tumor NOS, Multiple | |
Leukemia Lymphocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + + |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + +|
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Intermedia, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 2| 2| 2| 2| 2| 2| 4| 2| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|
| 7| 9| 6| 6| 9| 7| 7| 7| 0| 9| 4| 4| 6| 5| 7| 7| 7| 9| 9| 9| 7| 7| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 2| 3| 5| 6| 7| 9| 0| 1| 4| 5| 6| 9| 0| 2| 3| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Skin | X |
Leukemia Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Lymphoma Malignant Mixed| X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Leukemia Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Skin | X |
Histiocytic Sarcoma | |
Leukemia Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + M + M + + + + + M + + +|
Leukemia Lymphocytic | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 2| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 2| 2| 2| 2| 2| 2| 4| 2| 9| 9| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|
| 7| 9| 6| 6| 9| 7| 7| 7| 0| 9| 4| 4| 6| 5| 7| 7| 7| 9| 9| 9| 7| 7| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 2| 3| 5| 6| 7| 9| 0| 1| 4| 5| 6| 9| 0| 2| 3| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Leukemia Lymphocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + M M M M M M M + M M + M M M M M + M M + M + M +|
Adenoma | X X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Lymphocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| |
| 9| 0| 7| 9| 6| 7| 9| 7| 7| 7| 6| 9| 0| 7| 3| 7| 6| 7| 6| 9| 6| 6| 7| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| L |
| 8| 9| 0| 1| 2| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 3| 4| 5| 6| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | X | 1 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma | X X X | 6 |
Hepatocellular Adenoma | X X X X X X| 10 |
Hepatocellular Adenoma, Multiple | X X X X X X | 16 |
Histiocytic Sarcoma | X X X | 3 |
Ito Cell Tumor NOS, Multiple | X | 1 |
Leukemia Lymphocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + +| 14 |
Odontoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| |
| 9| 0| 7| 9| 6| 7| 9| 7| 7| 7| 6| 9| 0| 7| 3| 7| 6| 7| 6| 9| 6| 6| 7| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| L |
| 8| 9| 0| 1| 2| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 3| 4| 5| 6| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + + + + + + + + + + + + M + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Penis | + + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Leukemia Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
Mediastinal, Lymphoma Malignant Mixed| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + M + + + + + + + + + + +| 48 |
Histiocytic Sarcoma | X X X | 3 |
Leukemia Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma, Metastatic, Skin | | 1 |
Histiocytic Sarcoma | X X | 2 |
Leukemia Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + M M + + M + M + + + + + + + + + + + + + + +| 42 |
Leukemia Lymphocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| |
| 9| 0| 7| 9| 6| 7| 9| 7| 7| 7| 6| 9| 0| 7| 3| 7| 6| 7| 6| 9| 6| 6| 7| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| L |
| 8| 9| 0| 1| 2| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 3| 4| 5| 6| 9| 0| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M M M M M M M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X X X | 11 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 3 |
Histiocytic Sarcoma | X | 1 |
Leukemia Lymphocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + M M M M M M M M M M M M + + M + M + M + + + M +| 16 |
Adenoma | X| 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Renal Tubule, Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| |
| 9| 0| 7| 9| 6| 7| 9| 7| 7| 7| 6| 9| 0| 7| 3| 7| 6| 7| 6| 9| 6| 6| 7| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| L |
| 8| 9| 0| 1| 2| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 3| 4| 5| 6| 9| 0| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Histiocytic Sarcoma | X X X | 3 |
Leukemia Lymphocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
RTD | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 4| 5| 6| 8| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M + + + + M + + + + + + + + + + + M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
RTD | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6|
0 MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 9| 1| 2| 3| 4| 5| 6| 8| 0| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mediastinal | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + M M M + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | M M + + M + M + M M M M + + + M M M M M M M + + M|
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
RTD | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L |
0 MG/KG | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X | 2 |
Hepatocellular Adenoma | X X | 3 |
Lymphoma Malignant Lymphocytic | X| 1 |
__________________________________________________________________________|____________|
Mesentery | +| 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X| 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + M + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + M + + + +| 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
RTD | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L |
0 MG/KG | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X| 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | +| 1 |
Lymphoma Malignant Lymphocytic | X| 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Lymphocytic | X| 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| 45 |
Lymphoma Malignant Lymphocytic | X| 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M M M M M M M M M M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X X | 8 |
Alveolar/Bronchiolar Carcinoma | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | M + + + + M M M M M + M + + + M + M M + + + M + M| 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05121-99 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 03/15/95
Route: GAVAGE Time: 17:08:10
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| |
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
RTD | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| L |
0 MG/KG | 2| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X| 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
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