TDMS Study 05121-99 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: BATTELLE COLUMBUS DATE: 03/16/95
EXP: 05121 SCOPOLAMINE HYDROBROMIDE TRIHYDRATE TIME: 12:24:41
TEST: 99 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 03098C
CONT: N01-ES-85227 CAS: 6533-68-2
PATHOLOGIST: A. SINGER
--------------------------------------------------------------------------------
05121/07 - 05121/08 COMPARISON
REASONS FOR REMOVAL:
25022 Accidently Killed
25018 Dosing Accident
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE 001 0 MG/KG
INCLUDE 002 0 MG/KG
INCLUDE 003 RTD 0 MG/KG
INCLUDE 005 RTD 0 MG/KG
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: BATTELLE COLUMBUS DATE: 03/16/95
EXP: 05121 SCOPOLAMINE HYDROBROMIDE TRIHYDRATE TIME: 12:24:41
TEST: 99 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 03098C
CONT: N01-ES-85227 CAS: 6533-68-2
PATHOLOGIST: A. SINGER
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 722 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 294 447 540 647 680 683 694 700 707 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = RTD 0 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 49 |
| |
| UNCENSORED DEATHS |
| 515 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 722 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 722 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.0 98.0 96.0 94.0 94.0 92.0 82.0 |
| | |
| | |
|RTD | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 98.0 98.0 |
|0 MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG RTD |
| 0 MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 82.0% 98.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 599.1 515.0 |
|NATURAL DEATHS (C) | (48.1) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 699.9 717.9 |
|(STANDARD ERROR) | (10.6) ( 4.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 723 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 51 UNCENSORED DEATHS 16 CENSORED DEATHS 2 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 492 511 581 594 604 610 611 611 618 661 |
| 679 707 709 712 717 720 |
| CENSORED DEATHS |
| 7 373 |
| |
|--------------------------------------------------------------------------------|
| DOSE = RTD 0 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 47 |
| |
| UNCENSORED DEATHS |
| 492 562 628 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 723 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 723 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 95.9 89.8 79.6 67.3 |
| | |
| | |
|RTD | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 96.0 94.0 94.0 |
|0 MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG RTD |
| 0 MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 67.3% 94.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 633.6 560.7 |
|NATURAL DEATHS (C) | (17.9) (39.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 674.0 713.3 |
|(STANDARD ERROR) | (16.8) ( 5.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
RTD 0 MG/KG = 2
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2
|
|
|
98 + 1 1 2 2
|
|
|
96 + 1 1
|
P |
E |
R 94 + 1 1
C |
E |
N |
T 92 + 1 1
|
S |
U |
R 90 +
V |
I |
V |
A 88 + 1 1
L |
|
|
86 +
|
|
|
84 + 11
|
|
|
82 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 1 obs hidden.
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
RTD 0 MG/KG = 2
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1
|
| 1 1 2
| 1 2 1 2
95 +
| 1 1 2 2
P |
E | 1 1
R 90 + 11
C |
E |
N |
T 85 +
| 11
S |
U | 1 1
R 80 + 1 1
V |
I | 1 1
V |
A 75 + 11
L |
|
| 11
70 +
|
| 11
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.