TDMS Study 05217-99 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
T-BUTYLHYDROQUINONE
NTP Experiment-Test: 05217-99 Report: PEIRPT03
Study Type: CHRONIC Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
05217/03 -VS- 05217/04 COMPARISON
Facility: SOUTHERN RESEARCH INSTITUTE
Chemical CAS #: 1948-33-0
Lock Date: 05/26/93
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 UNTREATD CONTROL
Include 002 UNTREATD CONTROL
Include 005 RTD UNTRCONTROL
Include 006 RTD UNTRCONTROL
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70
Early Deaths
Moribund Sacrifice 40 39
Natural Death 10 3
Survivors
Terminal Sacrifice 10 18
Animals Examined Microscopically 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (58) (58)
Epithelium, Hyperplasia 1 (2%)
Intestine Large, Colon (60) (59)
Parasite Metazoan 6 (10%) 4 (7%)
Intestine Large, Rectum (59) (60)
Edema 1 (2%)
Parasite Metazoan 2 (3%) 5 (8%)
Intestine Large, Cecum (60) (60)
Edema 1 (2%)
Parasite Metazoan 2 (3%) 1 (2%)
Intestine Small, Duodenum (59) (59)
Erosion 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Liver (60) (60)
Angiectasis 1 (2%)
Basophilic Focus 26 (43%) 26 (43%)
Clear Cell Focus 2 (3%) 2 (3%)
Degeneration, Cystic 1 (2%)
Eosinophilic Focus 10 (17%) 7 (12%)
Hematopoietic Cell Proliferation 1 (2%) 2 (3%)
Hepatodiaphragmatic Nodule 12 (20%) 2 (3%)
Inflammation, Granulomatous 12 (20%) 7 (12%)
Inflammation, Subacute 1 (2%)
Mixed Cell Focus 2 (3%) 8 (13%)
Necrosis, Focal 6 (10%) 7 (12%)
Bile Duct, Hyperplasia 17 (28%) 23 (38%)
Hepatocyte, Vacuolization Cytoplasmic 14 (23%) 7 (12%)
Kupffer Cell, Pigmentation 12 (20%) 14 (23%)
Mesentery (11) (8)
Accessory Spleen 1 (9%) 2 (25%)
Fat, Necrosis 9 (82%) 5 (63%)
Pancreas (60) (60)
Atrophy 20 (33%) 15 (25%)
Metaplasia, Hepatocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Cytoplasmic Alteration 1 (2%)
Salivary Glands (60) (60)
Atrophy 2 (3%)
Stomach, Forestomach (60) (59)
Edema 4 (7%) 1 (2%)
Erosion 1 (2%) 1 (2%)
Ulcer 2 (3%) 4 (7%)
Epithelium, Hyperplasia 5 (8%)
Mucosa, Hyperplasia 5 (8%)
Stomach, Glandular (60) (59)
Edema 1 (2%) 1 (2%)
Erosion 3 (5%) 1 (2%)
Mineralization 1 (2%)
Ulcer 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60)
Cardiomyopathy 28 (47%) 29 (48%)
Mineralization 1 (2%)
Thrombosis 3 (5%) 2 (3%)
Schwann Cell, Hyperplasia 1 (2%)
Valve, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60)
Accessory Adrenal Cortical Nodule 11 (18%) 9 (15%)
Atrophy 1 (2%)
Degeneration, Fatty 9 (15%) 11 (18%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Diffuse 3 (5%) 1 (2%)
Hyperplasia, Focal 3 (5%) 7 (12%)
Hypertrophy, Focal 9 (15%) 5 (8%)
Necrosis 1 (2%)
Adrenal Medulla (60) (57)
Hyperplasia 5 (8%) 5 (9%)
Islets, Pancreatic (60) (60)
Hyperplasia 1 (2%)
Parathyroid Gland (52) (55)
Hyperplasia 1 (2%) 2 (4%)
Pituitary Gland (60) (59)
Pars Distalis, Angiectasis 8 (13%) 2 (3%)
Pars Distalis, Cyst 14 (23%) 9 (15%)
Pars Distalis, Hyperplasia, Focal 9 (15%) 11 (19%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Intermedia, Angiectasis 2 (3%)
Pars Intermedia, Cyst 2 (3%) 4 (7%)
Thyroid Gland (60) (60)
Ultimobranchial Cyst 2 (3%) 2 (3%)
C-Cell, Hyperplasia 8 (13%) 4 (7%)
Follicle, Cyst 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (58) (59)
Cyst 2 (3%) 5 (8%)
Cyst, Multiple 1 (2%)
Hyperplasia 3 (5%) 5 (8%)
Inflammation, Chronic 2 (3%) 3 (5%)
Inflammation, Suppurative 2 (3%) 2 (3%)
Ovary (60) (60)
Angiectasis 2 (3%)
Cyst 17 (28%) 6 (10%)
Uterus (60) (60)
Hydrometra 3 (5%) 4 (7%)
Hyperplasia, Cystic 4 (7%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60)
Depletion Cellular 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Myelofibrosis 2 (3%) 1 (2%)
Lymph Node (20) (19)
Iliac, Ectasia 1 (5%)
Mediastinal, Ectasia 1 (5%)
Mediastinal, Hemorrhage 3 (15%)
Mediastinal, Hyperplasia, Lymphoid 1 (5%)
Mediastinal, Pigmentation 14 (70%) 8 (42%)
Pancreatic, Ectasia 1 (5%)
Pancreatic, Pigmentation 1 (5%) 2 (11%)
Renal, Pigmentation 1 (5%) 6 (32%)
Lymph Node, Mandibular (59) (60)
Ectasia 2 (3%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 3 (5%) 5 (8%)
Hyperplasia, Lymphoid 13 (22%) 9 (15%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Pigmentation 20 (34%) 22 (37%)
Lymph Node, Mesenteric (58) (59)
Ectasia 2 (3%) 1 (2%)
Hemorrhage 2 (3%)
Hyperplasia, Lymphoid 2 (3%) 1 (2%)
Spleen (60) (60)
Fibrosis 3 (5%) 4 (7%)
Hematopoietic Cell Proliferation 15 (25%) 9 (15%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 24 (40%) 30 (50%)
Lymphoid Follicle, Atrophy 1 (2%)
Red Pulp, Atrophy 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60)
Dilatation 37 (62%) 51 (85%)
Galactocele 5 (8%) 1 (2%)
Hyperplasia 12 (20%) 3 (5%)
Skin (60) (60)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
Epidermis, Hyperplasia 1 (2%) 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60)
Fibrous Osteodystrophy 2 (3%)
Cranium, Osteopetrosis 8 (13%) 3 (5%)
Femur, Osteopetrosis 9 (15%) 3 (5%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60)
Atrophy 19 (32%) 17 (28%)
Hemorrhage 1 (2%)
Hydrocephalus 4 (7%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60)
Congestion 1 (2%)
Edema 1 (2%)
Foreign Body 1 (2%)
Hemorrhage 2 (3%) 2 (3%)
Infiltration Cellular, Histiocyte 28 (47%) 33 (55%)
Inflammation, Subacute 3 (5%) 1 (2%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (7%) 3 (5%)
Nose (60) (60)
Foreign Body 3 (5%) 1 (2%)
Inflammation, Suppurative 5 (8%) 3 (5%)
Goblet Cell, Hyperplasia 10 (17%) 7 (12%)
Mucosa, Hyperplasia 5 (8%) 4 (7%)
Mucosa, Metaplasia, Squamous 3 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2)
Inflammation, Chronic 1 (50%)
Eye (4)
Cataract 3 (75%)
Hemorrhage 1 (25%)
Retina, Degeneration 4 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60)
Glomerulosclerosis 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 2 (3%)
Mineralization 57 (95%) 59 (98%)
Nephropathy 37 (62%) 38 (63%)
Renal Tubule, Atrophy 1 (2%) 1 (2%)
Renal Tubule, Cytoplasmic Alteration 5 (8%) 5 (8%)
Renal Tubule, Dilatation 2 (3%)
Renal Tubule, Necrosis 2 (3%) 1 (2%)
Renal Tubule, Pigmentation 15 (25%) 17 (28%)
Transitional Epithelium, Hyperplasia 2 (3%) 5 (8%)
Urinary Bladder (59) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70
Early Deaths
Moribund Sacrifice 48 41
Natural Death 4 6
Survivors
Moribund Sacrifice 2
Natural Death 1
Terminal Sacrifice 8 10
Animals Examined Microscopically 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (58) (60)
Parasite Metazoan 7 (12%) 7 (12%)
Intestine Large, Rectum (59) (59)
Edema 2 (3%)
Parasite Metazoan 5 (8%) 4 (7%)
Intestine Large, Cecum (60) (60)
Edema 3 (5%) 3 (5%)
Parasite Metazoan 1 (2%)
Intestine Small, Duodenum (60) (60)
Ulcer 3 (5%)
Epithelium, Hyperplasia 2 (3%)
Intestine Small, Jejunum (60) (60)
Epithelium, Hyperplasia 1 (2%)
Liver (60) (60)
Angiectasis 10 (17%) 5 (8%)
Basophilic Focus 7 (12%) 5 (8%)
Clear Cell Focus 1 (2%)
Degeneration, Cystic 23 (38%) 6 (10%)
Eosinophilic Focus 10 (17%) 6 (10%)
Eosinophilic Focus, Multiple 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 7 (12%) 2 (3%)
Mixed Cell Focus 2 (3%)
Necrosis, Focal 8 (13%) 7 (12%)
Thrombosis 1 (2%)
Bile Duct, Cyst 2 (3%)
Bile Duct, Hyperplasia 52 (87%) 45 (75%)
Centrilobular, Necrosis 2 (3%)
Hepatocyte, Vacuolization Cytoplasmic 6 (10%) 2 (3%)
Kupffer Cell, Hyperplasia 1 (2%)
Kupffer Cell, Pigmentation 11 (18%) 19 (32%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (20) (8)
Accessory Spleen 1 (5%) 2 (25%)
Fat, Necrosis 16 (80%) 4 (50%)
Pancreas (60) (58)
Atrophy 15 (25%) 21 (36%)
Acinus, Cytoplasmic Alteration 3 (5%)
Acinus, Hyperplasia, Focal 2 (3%)
Salivary Glands (60) (60)
Atrophy 1 (2%)
Stomach, Forestomach (60) (60)
Edema 9 (15%)
Hyperplasia 8 (13%) 5 (8%)
Ulcer 8 (13%) 1 (2%)
Mucosa, Hyperplasia 1 (2%)
Stomach, Glandular (60) (60)
Edema 1 (2%) 1 (2%)
Erosion 1 (2%) 1 (2%)
Mineralization 1 (2%)
Ulcer 3 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (60) (60)
Hypertrophy 1 (2%) 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Heart (60) (60)
Cardiomyopathy 40 (67%) 34 (57%)
Necrosis 1 (2%)
Thrombosis 6 (10%) 5 (8%)
Endocardium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60)
Accessory Adrenal Cortical Nodule 17 (28%) 13 (22%)
Angiectasis 1 (2%)
Degeneration, Fatty 9 (15%) 13 (22%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 4 (7%) 2 (3%)
Hypertrophy, Focal 6 (10%) 5 (8%)
Necrosis 1 (2%)
Adrenal Medulla (60) (59)
Hyperplasia 26 (43%) 18 (31%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Islets, Pancreatic (60) (58)
Hyperplasia 3 (5%) 2 (3%)
Parathyroid Gland (55) (56)
Hyperplasia 6 (11%)
Pituitary Gland (60) (57)
Pars Distalis, Angiectasis 4 (7%) 3 (5%)
Pars Distalis, Cyst 6 (10%) 7 (12%)
Pars Distalis, Cyst, Hemorrhagic 1 (2%)
Pars Distalis, Hyperplasia, Focal 10 (17%) 14 (25%)
Pars Intermedia, Cyst 1 (2%) 2 (4%)
Thyroid Gland (60) (60)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 9 (15%) 5 (8%)
Follicle, Cyst 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60)
Atypia Cellular 27 (45%) 25 (42%)
Preputial Gland (60) (60)
Cyst 3 (5%) 3 (5%)
Hyperplasia 3 (5%) 1 (2%)
Inflammation, Chronic 26 (43%) 9 (15%)
Inflammation, Suppurative 3 (5%) 1 (2%)
Prostate (60) (60)
Cyst 1 (2%)
Fibrosis 3 (5%)
Inflammation, Chronic 5 (8%)
Inflammation, Suppurative 36 (60%) 28 (47%)
Epithelium, Hyperplasia 11 (18%) 3 (5%)
Testes (60) (60)
Atrophy 2 (3%)
Interstitial Cell, Hyperplasia 4 (7%) 3 (5%)
Seminiferous Tubule, Atrophy 7 (12%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60)
Hyperplasia 6 (10%) 2 (3%)
Myelofibrosis 4 (7%) 8 (13%)
Lymph Node (33) (36)
Iliac, Hemorrhage 1 (3%)
Inguinal, Hyperplasia, Lymphoid 2 (6%)
Mediastinal, Hemorrhage 3 (9%) 2 (6%)
Mediastinal, Hyperplasia, Lymphoid 1 (3%)
Mediastinal, Pigmentation 13 (39%) 19 (53%)
Pancreatic, Pigmentation 9 (27%) 8 (22%)
Renal, Hemorrhage 1 (3%) 1 (3%)
Renal, Pigmentation 8 (24%) 7 (19%)
Lymph Node, Mandibular (60) (60)
Ectasia 3 (5%) 2 (3%)
Hemorrhage 2 (3%) 1 (2%)
Hyperplasia, Lymphoid 11 (18%) 5 (8%)
Hyperplasia, Plasma Cell 1 (2%)
Pigmentation 6 (10%) 13 (22%)
Lymph Node, Mesenteric (60) (60)
Ectasia 7 (12%) 2 (3%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 3 (5%) 1 (2%)
Spleen (60) (60)
Congestion 1 (2%)
Fibrosis 21 (35%) 13 (22%)
Hematopoietic Cell Proliferation 7 (12%) 2 (3%)
Metaplasia, Lipocyte 1 (2%)
Necrosis 2 (3%) 2 (3%)
Pigmentation, Hemosiderin 13 (22%) 3 (5%)
Lymphoid Follicle, Atrophy 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (57) (58)
Dilatation 23 (40%) 16 (28%)
Galactocele 5 (9%)
Hyperplasia 7 (12%) 7 (12%)
Skin (60) (60)
Cyst Epithelial Inclusion 2 (3%)
Hyperkeratosis 1 (2%)
Hyperplasia 1 (2%)
Epidermis, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60)
Fibrous Osteodystrophy 6 (10%)
Hyperostosis 1 (2%)
Femur, Osteopetrosis 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60)
Atrophy 12 (20%) 3 (5%)
Hemorrhage 2 (3%) 1 (2%)
Hydrocephalus 4 (7%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60)
Congestion 2 (3%) 1 (2%)
Edema 1 (2%) 3 (5%)
Hemorrhage 3 (5%) 4 (7%)
Infiltration Cellular, Histiocyte 19 (32%) 14 (23%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (7%) 5 (8%)
Nose (60) (60)
Foreign Body 6 (10%) 3 (5%)
Inflammation 1 (2%)
Inflammation, Suppurative 17 (28%) 5 (8%)
Goblet Cell, Hyperplasia 5 (8%) 8 (13%)
Mucosa, Hyperplasia 14 (23%) 8 (13%)
Mucosa, Metaplasia, Squamous 8 (13%) 7 (12%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (1)
Atrophy 2 (50%)
Cataract 1 (25%) 1 (100%)
Retina, Degeneration 1 (25%) 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/07/95
Route: DOSED FEED Time: 14:28:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60)
Cyst 2 (3%) 2 (3%)
Infiltration Cellular, Lipocyte 1 (2%)
Inflammation, Suppurative 9 (15%)
Mineralization 12 (20%) 4 (7%)
Nephropathy 60 (100%) 51 (85%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) 1 (2%)
Renal Tubule, Atrophy 1 (2%)
Renal Tubule, Necrosis 3 (5%) 3 (5%)
Renal Tubule, Pigmentation 18 (30%) 17 (28%)
Transitional Epithelium, Hyperplasia 13 (22%) 1 (2%)
Urinary Bladder (60) (60)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%)
Transitional Epithelium, Hyperplasia 2 (3%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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