TDMS Study 05217-99 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) T-BUTYLHYDROQUINONE NTP Experiment-Test: 05217-99 Report: PEIRPT05 Study Type: CHRONIC Date: 04/10/95 Route: DOSED FEED Time: 14:53:49 05217/03 -VS- 05217/04 COMPARISON Facility: SOUTHERN RESEARCH INSTITUTE Chemical CAS #: 1948-33-0 Lock Date: 05/26/93 Cage Range: All Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 001 UNTREATD CONTROL Include 002 UNTREATD CONTROL Include 005 RTD UNTRCONTROL Include 006 RTD UNTRCONTROL a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95 Route: DOSED FEED Time: 14:53:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE UNTREATD RTD UNTR CONTROL CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 70 70 Early Deaths Moribund Sacrifice 40 39 Natural Death 10 3 Survivors Terminal Sacrifice 10 18 Animals Examined Microscopically 60 60 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Small, Ileum (60) (60) Liver (60) (60) Hepatocellular Adenoma 1 (2%) Mesentery (11) (8) Sarcoma Stromal, Metastatic, Uterus 1 (9%) Pancreas (60) (60) Sarcoma Stromal, Metastatic, Uterus 1 (2%) Salivary Glands (60) (60) Stomach, Forestomach (60) (59) Stomach, Glandular (60) (59) Tongue (1) Squamous Cell Papilloma 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (60) (60) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (60) (60) Adenoma 4 (7%) Adrenal Medulla (60) (57) Pheochromocytoma Benign 2 (3%) 3 (5%) Pheochromocytoma Benign, Multiple 1 (2%) Islets, Pancreatic (60) (60) Adenoma 2 (3%) 1 (2%) Parathyroid Gland (52) (55) Adenoma 2 (4%) Pituitary Gland (60) (59) Pars Distalis, Adenoma 26 (43%) 30 (51%) Pars Distalis, Carcinoma 2 (3%) Page 2 NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95 Route: DOSED FEED Time: 14:53:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE UNTREATD RTD UNTR CONTROL CONTROL ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Thyroid Gland (60) (60) C-Cell, Adenoma 7 (12%) 3 (5%) C-Cell, Carcinoma 1 (2%) Follicular Cell, Carcinoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Peritoneum (1) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (58) (59) Adenoma 6 (10%) 3 (5%) Carcinoma 6 (10%) 2 (3%) Ovary (60) (60) Granulosa Cell Tumor Malignant 1 (2%) Granulosa Cell Tumor Benign 1 (2%) 2 (3%) Uterus (60) (60) Leiomyoma 1 (2%) Polyp Stromal 6 (10%) 8 (13%) Polyp Stromal, Multiple 1 (2%) Sarcoma Stromal 2 (3%) Vagina (1) Squamous Cell Papilloma 1 (100%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (60) (60) Lymph Node (20) (19) Lymph Node, Mandibular (59) (60) Lymph Node, Mesenteric (58) (59) Spleen (60) (60) Hemangiosarcoma 1 (2%) Thymus (56) (57) Thymoma Benign 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (60) (60) Adenoma 3 (5%) Carcinoma 8 (13%) 1 (2%) Fibroadenoma 28 (47%) 22 (37%) Fibroadenoma, Multiple 15 (25%) 8 (13%) Page 3 NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95 Route: DOSED FEED Time: 14:53:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE UNTREATD RTD UNTR CONTROL CONTROL ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont Skin (60) (60) Basal Cell Carcinoma 1 (2%) 1 (2%) Trichoepithelioma 1 (2%) Subcutaneous Tissue, Fibroma 3 (5%) 1 (2%) Subcutaneous Tissue, Fibrosarcoma 1 (2%) Subcutaneous Tissue, Lipoma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (1) (1) Sarcoma Stromal, Metastatic, Uterus 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (60) (60) Astrocytoma Malignant 1 (2%) Oligodendroglioma Malignant 1 (2%) Spinal Cord (2) (4) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (60) (60) Alveolar/Bronchiolar Adenoma 2 (3%) 2 (3%) Alveolar/Bronchiolar Carcinoma 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (1) Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (60) (60) Sarcoma Stromal, Metastatic, Uterus 1 (2%) Renal Tubule, Adenoma 1 (2%) Urinary Bladder (59) (60) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(60) *(60) Leukemia Mononuclear 27 (45%) 37 (62%) * Number of animals with any tissue examined microscopically Page 4 NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95 Route: DOSED FEED Time: 14:53:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE UNTREATD RTD UNTR CONTROL CONTROL ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont Multiple Organs *(60) *(60) Mesothelioma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ Page 5 NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95 Route: DOSED FEED Time: 14:53:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE UNTREATD RTD UNTR CONTROL CONTROL ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 59 59 Total Primary Neoplasms 164 133 Total Animals with Benign Neoplasms 52 46 Total Benign Neoplasms 112 88 Total Animals with Malignant Neoplasms 41 40 Total Malignant Neoplasms 52 45 Total Animals with Metastatic Neoplasms 2 Total Metastatic Neoplasm 5 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95 Route: DOSED FEED Time: 14:53:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE UNTREATD RTD UNTR CONTROL CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 70 70 Early Deaths Moribund Sacrifice 48 41 Natural Death 4 6 Survivors Moribund Sacrifice 2 Natural Death 1 Terminal Sacrifice 8 10 Animals Examined Microscopically 60 60 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (58) (60) Intestine Large, Cecum (60) (60) Intestine Small, Duodenum (60) (60) Intestine Small, Jejunum (60) (60) Leiomyosarcoma 1 (2%) Intestine Small, Ileum (60) (60) Liver (60) (60) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Hepatocellular Adenoma 4 (7%) Histiocytic Sarcoma 1 (2%) Mesentery (20) (8) Histiocytic Sarcoma 1 (5%) Schwannoma Malignant 1 (5%) Oral Mucosa (1) Squamous Cell Carcinoma 1 (100%) Pancreas (60) (58) Acinus, Adenoma 3 (5%) Salivary Glands (60) (60) Stomach, Forestomach (60) (60) Stomach, Glandular (60) (60) Tongue (1) (1) Squamous Cell Carcinoma 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (60) (60) Schwannoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95 Route: DOSED FEED Time: 14:53:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE UNTREATD RTD UNTR CONTROL CONTROL ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (60) (60) Adenoma 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Adrenal Medulla (60) (59) Pheochromocytoma Malignant 1 (2%) 2 (3%) Pheochromocytoma Complex 1 (2%) Pheochromocytoma Benign 13 (22%) 7 (12%) Pheochromocytoma Benign, Multiple 1 (2%) 5 (8%) Islets, Pancreatic (60) (58) Adenoma 5 (8%) 2 (3%) Carcinoma 1 (2%) Pituitary Gland (60) (57) Pars Distalis, Adenoma 19 (32%) 13 (23%) Thyroid Gland (60) (60) C-Cell, Adenoma 5 (8%) 7 (12%) Follicular Cell, Carcinoma 2 (3%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Peritoneum (1) (3) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (60) (60) Adenoma 5 (8%) 1 (2%) Carcinoma 2 (3%) 1 (2%) Prostate (60) (60) Adenoma 2 (3%) Seminal Vesicle (60) (60) Testes (60) (60) Bilateral, Interstitial Cell, Adenoma 42 (70%) 52 (87%) Interstitial Cell, Adenoma 13 (22%) 7 (12%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (60) (60) Lymph Node (33) (36) Deep Cervical, Carcinoma, Metastatic, Thyroid Gland 1 (3%) Lymph Node, Mandibular (60) (60) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Lymph Node, Mesenteric (60) (60) Spleen (60) (60) Page 8 NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95 Route: DOSED FEED Time: 14:53:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE UNTREATD RTD UNTR CONTROL CONTROL ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Fibroma 2 (3%) Histiocytic Sarcoma 1 (2%) Sarcoma 1 (2%) Thymus (58) (54) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (57) (58) Adenoma 1 (2%) Carcinoma 1 (2%) Fibroadenoma 9 (16%) 4 (7%) Fibroadenoma, Multiple 1 (2%) Skin (60) (60) Basal Cell Carcinoma 1 (2%) 1 (2%) Keratoacanthoma 3 (5%) 1 (2%) Keratoacanthoma, Multiple 1 (2%) Squamous Cell Papilloma 2 (3%) Trichoepithelioma 2 (3%) Sebaceous Gland, Adenoma 1 (2%) 1 (2%) Subcutaneous Tissue, Fibroma 3 (5%) 6 (10%) Subcutaneous Tissue, Fibroma, Multiple 1 (2%) Subcutaneous Tissue, Fibrosarcoma 1 (2%) Subcutaneous Tissue, Hemangioma 1 (2%) Subcutaneous Tissue, Hemangiosarcoma 1 (2%) Subcutaneous Tissue, Schwannoma Benign 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (60) (60) Astrocytoma Malignant 1 (2%) Oligodendroglioma Malignant 1 (2%) Spinal Cord (2) (2) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (60) (60) Alveolar/Bronchiolar Adenoma 3 (5%) 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Histiocytic Sarcoma 1 (2%) Page 9 NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95 Route: DOSED FEED Time: 14:53:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE UNTREATD RTD UNTR CONTROL CONTROL ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont Nose (60) (60) Squamous Cell Papilloma 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (2) Carcinoma 2 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (60) (60) Lipoma 1 (2%) Renal Tubule, Adenoma 2 (3%) Transitional Epithelium, Carcinoma 1 (2%) Urinary Bladder (60) (60) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(60) *(60) Histiocytic Sarcoma 1 (2%) Leukemia Mononuclear 39 (65%) 46 (77%) Lymphoma Malignant 1 (2%) Mesothelioma Malignant 1 (2%) 3 (5%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 10 NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95 Route: DOSED FEED Time: 14:53:49 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE UNTREATD RTD UNTR CONTROL CONTROL ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 60 59 Total Primary Neoplasms 207 166 Total Animals with Benign Neoplasms 60 59 Total Benign Neoplasms 148 107 Total Animals with Malignant Neoplasms 51 52 Total Malignant Neoplasms 59 59 Total Animals with Metastatic Neoplasms 1 Total Metastatic Neoplasm 5 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 11 ------------------------------------------------------------ ---------- END OF REPORT 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